Web Desc
Cell Biology of the Heart: Beyond the Myocyte-Centric View
joint with Heart Disease and Regeneration: Insights from Development
Organizer(s): Peter Kohl, Robert G. Gourdie and Stefanie Dimmeler
Date: March 01 - 06, 2015
Location: Copper Mountain Resort, Copper Mountain, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
The heart is a muscle, and as such, much of the basic and applied research into cardiac structure and function has focused on cardiac myocytes. However, the majority of heart cells are non-myocytes. Prominent examples include cells comprising the coronary vasculature, fat, connective tissue (e.g., fibroblasts), nerves and immune cells. It has become increasingly clear that these cells are not merely bystanders of myocyte function, but active participants with important signaling roles that contribute to cardiac development, cell differentiation and function of the healthy and diseased heart. This Keystone Symposia meeting is unique, in that, for the first time, it brings together internationally-leading experts in the field of non-myocyte contributions to cardiac structure and function. It aims to address: 1) Roles of non-myocytes for cardiac cell fate determination and development; 2) Mechanisms of non-myocyte – myocyte signaling interactions; 3) Effects of these interactions in normal and diseased heart; and 4) Relevance of non-myocytes as targets for therapeutic interventions. Participants should leave this meeting with a more holistic understanding of the heart as a multi-cellular organ, and a broadened horizon to support their individual research. This is the first high-level symposium with an explicit focus on reviewing the current state of a new frontier of cardiac cell biology: non-myocyte roles in the development, regulation and adaptation of cardiac performance. The symposium should contribute to a paradigm shift that is taking place in the field, driven by the appreciation that a myocyte-centric view of the heart will always be limited in its ability to deliver the mechanistic understanding of cardiac structure and function that is required for improved predictive and therapeutic action.
Scholarship Deadline: November 4 2014
Discounted Abstract Deadline: November 4 2014
Abstract Deadline: December 3 2014
Discounted Registration Deadline: January 6 2015
We gratefully acknowledge additional support for this conference from:

American Heart Association's Councils on Basic CV Sciences, CV Disease in the Young, and Functional Genomics and Translational Biology
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

NeoStem, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL126405-01
Funding for this conference was made possible (in part) by 1R13HL126405-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 01 | 4:00PM - 8:00PM
Arrival and Registration
Room: Kokopelli's


Sunday, March 01 | 6:00PM - 8:00PM
Welcome Mixer
Room: Kokopelli's
No registration fees are used to fund alcohol served at this function.

Monday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's/Ptarmigan B-C


Monday, March 02 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Big Horn Ballroom

Speaker 1 of 3
* Stefanie Dimmeler, University of Frankfurt, Germany

Monday, March 02 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Big Horn Ballroom

Speaker 2 of 3
* Vincent M. Christoffels, Academic Medical Center, Netherlands

Monday, March 02 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Big Horn Ballroom

Speaker 3 of 3
Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Regulation of Cardiovascular Development

Monday, March 02 | 9:00AM - 11:15AM
Potential and Pitfalls of Cell Reprogramming (Joint)
Room: Big Horn Ballroom

Speaker 1 of 3
Eric N. Olson, University of Texas Southwestern Medical Center, USA
New Strategies for Heart Regeneration and Repair

Monday, March 02 | 9:00AM - 11:15AM
Potential and Pitfalls of Cell Reprogramming (Joint)
Room: Big Horn Ballroom

Speaker 2 of 3
Sean M. Wu, Stanford School of Medicine, USA
Molecular Basis of Cardiomyocyte Programming and Reprogramming

Monday, March 02 | 9:00AM - 11:15AM
Potential and Pitfalls of Cell Reprogramming (Joint)
Room: Big Horn Ballroom

Speaker 3 of 3
Deepak Srivastava, Gladstone Institutes, USA
Reprogramming Approaches for Cardiovascular Disease

Monday, March 02 | 9:40AM - 10:00AM
Coffee Break
Room: Kokopelli's


Monday, March 02 | 11:15AM - 1:00PM
Poster Setup
Room: Ptarmigan Ballroom


Monday, March 02 | 11:15AM - 2:30PM
On Own for Lunch


Monday, March 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Ptarmigan Ballroom


Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Myocyte / Non-Myocyte Interactions in Healthy an
d Diseased Myocardium
Room: Big Horn C

Speaker 1 of 9
* Milena Bastos Furtado, The Jackson Lab, USA

Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Myocyte / Non-Myocyte Interactions in Healthy an
d Diseased Myocardium
Room: Big Horn C

Speaker 2 of 9
* Patrizia Camelliti, University of Surrey, UK

Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Myocyte / Non-Myocyte Interactions in Healthy an
d Diseased Myocardium
Room: Big Horn C

Speaker 3 of 9
Emily L. Ongstad, MedImmune, USA
A Cx43 C-Terminal Mimetic Peptide Alters Myocyte-Fibroblast Interactions via Cx43 in the Injury Border Zone

Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Myocyte / Non-Myocyte Interactions in Healthy an
d Diseased Myocardium
Room: Big Horn C

Speaker 4 of 9
J. Travis Hinson, The Jackson Laboratory, USA
Crosstalk between AMPK in Myocytes and Fibroblasts Regulates Cardiac Fibrosis

Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Myocyte / Non-Myocyte Interactions in Healthy an
d Diseased Myocardium
Room: Big Horn C

Speaker 5 of 9
Margaux A. Horn, University of Manchester, UK
Remodelling of the Cardiac Extracellular Matrix following Induction and Recovery from Pacing-Induced Heart Failure in Sheep

Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Myocyte / Non-Myocyte Interactions in Healthy an
d Diseased Myocardium
Room: Big Horn C

Speaker 6 of 9
Inês J. Marques, Centro Nacional de Investigaciones Cardiovasculres, Spain
The Lysyl Oxidase Gene Family in the Regeneration of the Cryoinjured Zebrafish Ventricle

Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Myocyte / Non-Myocyte Interactions in Healthy an
d Diseased Myocardium
Room: Big Horn C

Speaker 7 of 9
Arjun Deb, University of California, Los Angeles, USA
Mesenchymal-Endothelial-Transition Contributes to Neovascularization after Acute Cardiac Injury

Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Myocyte / Non-Myocyte Interactions in Healthy an
d Diseased Myocardium
Room: Big Horn C

Speaker 8 of 9
Celinda M. Kofron, Rhode Island Hospital / Brown Medical School, USA
Modulation of Cardiomyocyte Electrical Activity by Cardiac Fibroblasts in a Novel 3D Platform

Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Myocyte / Non-Myocyte Interactions in Healthy an
d Diseased Myocardium
Room: Big Horn C

Speaker 9 of 9
Marco Tarantola, MPI for Dynamics and Self-Organization, Germany
Electromechanical Connectivity of Cardiomyocytes under Fibrotic Conditions

Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Emerging Technologies: Genomics and Reprogrammin
g
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 1 of 8
* Benoit G. Bruneau, Gladstone Institutes, USA


Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Emerging Technologies: Genomics and Reprogrammin
g
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 2 of 8
* Laurie A. Boyer, Massachusetts Institute of Technology, USA


Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Emerging Technologies: Genomics and Reprogrammin
g
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 3 of 8
Joseph A. Goldman, Duke University, USA
Profiling of Dynamic Gene-Regulatory Programs during Zebrafish Heart Regeneration Using the Replacement Histone H3.3


Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Emerging Technologies: Genomics and Reprogrammin
g
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 4 of 8
Jonathon Hill, University of Utah, USA
Self-Organized Map Analysis of Temporal RNA-Seq Datasets Reveals Gene Regulatory Interactions during Heart Looping and Atrio-Ventricular Canal Formation


Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Emerging Technologies: Genomics and Reprogrammin
g
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 5 of 8
Kelvin See, University of Pennsylvania, USA
Single Cardiomyocyte Nuclear RNA-Seq Reveals a De-Differentiation Stress Response in vivo


Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Emerging Technologies: Genomics and Reprogrammin
g
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 6 of 8
Emily S. Noël, Hubrecht Institute, Netherlands
Identification of Novel Regulators of Embryonic Laterality Using Tomo-Seq


Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Emerging Technologies: Genomics and Reprogrammin
g
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 7 of 8
Nikhil V. Munshi, University of Texas Southwestern Medical Center, USA
Induction of Diverse Cardiac Cell Types by Reprogramming Fibroblasts with Cardiac Transcription Factors


Monday, March 02 | 2:30PM - 4:30PM
Workshop 1: Emerging Technologies: Genomics and Reprogrammin
g
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 8 of 8
Li Qian, University of North Carolina at Chapel Hill, USA
Stoichiometry of Gata4, Mef2c and Tbx5 Influences the Efficiency and Quality of iCM Reprogramming


Monday, March 02 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Monday, March 02 | 5:00PM - 7:00PM
Non-Myocytes in Cardiac Development
Room: Big Horn C

Speaker 1 of 5
* Roger R. Markwald, Medical University of South Carolina, USA

Monday, March 02 | 5:00PM - 7:00PM
Non-Myocytes in Cardiac Development
Room: Big Horn C

Speaker 2 of 5
Edward E. Morrisey, University of Pennsylvania, USA
Mechanisms Promoting Cardiomyocyte Proliferation and Replenishment

Monday, March 02 | 5:00PM - 7:00PM
Non-Myocytes in Cardiac Development
Room: Big Horn C

Speaker 3 of 5
Russell Norris, Medical University of South Carolina, USA
Daschous-Hippo: Novel Regulators of Myocyte – Non-Myocyte Interaction and Cardiac Growth

Monday, March 02 | 5:00PM - 7:00PM
Non-Myocytes in Cardiac Development
Room: Big Horn C

Speaker 4 of 5
Rhonda Bassel-Duby, University of Texas Southwestern Medical Center, USA
A Twist of Fate in Cardiac Regeneration

Monday, March 02 | 5:00PM - 7:00PM
Non-Myocytes in Cardiac Development
Room: Big Horn C

Speaker 5 of 5
Milena Bastos Furtado, The Jackson Lab, USA
Short Talk: Cardiogenic Transcriptional Network in Heart Fibroblast Biology and Disease

Monday, March 02 | 5:00PM - 7:00PM
Epigenetics of Cardiac Development
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 1 of 5
* Brian L. Black, University of California, San Francisco, USA


Monday, March 02 | 5:00PM - 7:00PM
Epigenetics of Cardiac Development
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 2 of 5
Benoit G. Bruneau, Gladstone Institutes, USA
Transcriptional Regulation of Heart Development


Monday, March 02 | 5:00PM - 7:00PM
Epigenetics of Cardiac Development
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 3 of 5
Hesham A. Sadek, University of Texas Southwestern Medical Center, USA
Meis 1 in Heart Regeneration


Monday, March 02 | 5:00PM - 7:00PM
Epigenetics of Cardiac Development
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 4 of 5
Laurie A. Boyer, Massachusetts Institute of Technology, USA
Transcriptional Regulation of Cardiac Cell Fate


Monday, March 02 | 5:00PM - 7:00PM
Epigenetics of Cardiac Development
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 5 of 5
Dalit May, Hebrew University of Jerusalem, Israel
Short Talk: Chromatin Dynamics in Myocardial Hibernation - The Role of Transcriptional Enhancers in Chronic Cardiac Ischemia


Monday, March 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ptarmigan Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, March 02 | 7:30PM - 10:00PM
Poster Session 1
Room: Ptarmigan Ballroom
Poster sessions provide exciting opportunities for engagement between all levels of investigators. Abstracts beginning with X1 or X2 and the number 1 are featured during this poster session.

Tuesday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's/Ptarmigan B-C


Tuesday, March 03 | 8:00AM - 11:00AM
Cardiac Non-Myocytes as Signaling Hubs: Biochemical Signals
Room: Big Horn C

Speaker 1 of 6
* Robert G. Gourdie, Virginia Tech Carilion Research Institute, USA

Tuesday, March 03 | 8:00AM - 11:00AM
Cardiac Non-Myocytes as Signaling Hubs: Biochemical Signals
Room: Big Horn C

Speaker 2 of 6
Michelle D. Tallquist, University of Hawaii, USA
Fibroblast Roles in Cardiac Function and Disease

Tuesday, March 03 | 8:00AM - 11:00AM
Cardiac Non-Myocytes as Signaling Hubs: Biochemical Signals
Room: Big Horn C

Speaker 3 of 6
Mark L. Entman, Baylor College of Medicine, USA
Fibroblasts of Myeloid Origin and Immune-Inflammatory Dysregulation

Tuesday, March 03 | 8:00AM - 11:00AM
Cardiac Non-Myocytes as Signaling Hubs: Biochemical Signals
Room: Big Horn C

Speaker 4 of 6
Kenneth Walsh, University of Virginia School of Medicine, USA
Non-Myocyte Contributions to Cardiokines: Deciphering the Cardiac Secretome

Tuesday, March 03 | 8:00AM - 11:00AM
Cardiac Non-Myocytes as Signaling Hubs: Biochemical Signals
Room: Big Horn C

Speaker 5 of 6
Thomas Thum, Medical School Hannover, Germany
Noncoding RNAs in Cardiac Cell-Cell Communication

Tuesday, March 03 | 8:00AM - 11:00AM
Cardiac Non-Myocytes as Signaling Hubs: Biochemical Signals
Room: Big Horn C

Speaker 6 of 6
Katarzyna A. Cieslik, Baylor College of Medicine, USA
Short Talk: Mesenchymal Fibroblasts Promote Myeloid Fibroblast Formation in the Aging Mouse Heart

Tuesday, March 03 | 8:00AM - 11:15AM
Regulatory Networks for Cardiac Rhythm
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 1 of 7
* Ivan P. Moskowitz, University of Chicago, USA


Tuesday, March 03 | 8:00AM - 11:15AM
Regulatory Networks for Cardiac Rhythm
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 2 of 7
Patrick T. Ellinor, Massachusetts General Hospital, USA
Genetics of Atrial Fibrillation


Tuesday, March 03 | 8:00AM - 11:15AM
Regulatory Networks for Cardiac Rhythm
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 3 of 7
Vincent M. Christoffels, Academic Medical Center, Netherlands
Transcriptional Regulation of the Electrical Activity Pattern of the Heart


Tuesday, March 03 | 8:00AM - 11:15AM
Regulatory Networks for Cardiac Rhythm
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 4 of 7
Stacey L. Rentschler, Washington University School of Medicine, USA
Canonical Wnt Signaling Regulates Myocardial Electrical Programming


Tuesday, March 03 | 8:00AM - 11:15AM
Regulatory Networks for Cardiac Rhythm
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 5 of 7
Sylvia M. Evans, University of California, San Diego, USA
Role of Islet1 in Sinus Node Development


Tuesday, March 03 | 8:00AM - 11:15AM
Regulatory Networks for Cardiac Rhythm
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 6 of 7
David S. Park, New York University School of Medicine, USA
Short Talk: A Neuregulin-1/Er81/Nkx2-5 Signaling Cascade Confers Rapid Conduction in the Heart


Tuesday, March 03 | 8:00AM - 11:15AM
Regulatory Networks for Cardiac Rhythm
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 7 of 7
Stephanie Iris Protze, University Health Network, Canada
Short Talk: Sinoatrial Node Pacemaker Cells Generated from Human Pluripotent Stem Cells Can Function as Biological Pacemaker


Tuesday, March 03 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Tuesday, March 03 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, March 03 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Tuesday, March 03 | 5:00PM - 7:00PM
Cardiac Non-Myocytes as Signaling Hubs: Biophysical Signals
Room: Big Horn C

Speaker 1 of 5
* Natalia Trayanova, Johns Hopkins University, USA

Tuesday, March 03 | 5:00PM - 7:00PM
Cardiac Non-Myocytes as Signaling Hubs: Biophysical Signals
Room: Big Horn C

Speaker 2 of 5
Peter Kohl, University of Freiburg, Germany
Myocyte-Nonmyocyte Electro-Mechanical Cross-Talk

Tuesday, March 03 | 5:00PM - 7:00PM
Cardiac Non-Myocytes as Signaling Hubs: Biophysical Signals
Room: Big Horn C

Speaker 3 of 5
Robert G. Gourdie, Virginia Tech Carilion Research Institute, USA
Connexins as Regulators of Fibrosis and Clinical Targets for Scar Reduction Therapies

Tuesday, March 03 | 5:00PM - 7:00PM
Cardiac Non-Myocytes as Signaling Hubs: Biophysical Signals
Room: Big Horn C

Speaker 4 of 5
Douglas W. Losordo, Caladrius Biosciences, Inc., USA
The Microvasculature as a Therapeutic Target in Ischemic Tissue Repair

Tuesday, March 03 | 5:00PM - 7:00PM
Cardiac Non-Myocytes as Signaling Hubs: Biophysical Signals
Room: Big Horn C

Speaker 5 of 5
Salim Seyfried, University of Potsdam, Germany
Short Talk: Blood Flow and Bmp Signaling Control Endocardial Chamber Morphogenesis

Tuesday, March 03 | 5:00PM - 7:00PM
Gene Regulatory Networks
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 1 of 5
* James F. Martin, Baylor College of Medicine, USA


Tuesday, March 03 | 5:00PM - 7:00PM
Gene Regulatory Networks
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 2 of 5
Ivan P. Moskowitz, University of Chicago, USA
Gene Regulatory Networks for Cardiac Form and Function


Tuesday, March 03 | 5:00PM - 7:00PM
Gene Regulatory Networks
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 3 of 5
Sophia Y. Tsai, Baylor College of Medicine, USA
Role of COUP-TFII in Atrial Specification and Heart Failure


Tuesday, March 03 | 5:00PM - 7:00PM
Gene Regulatory Networks
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 4 of 5
Brian L. Black, University of California, San Francisco, USA
Transcriptional Pathways Controlling OFT Development


Tuesday, March 03 | 5:00PM - 7:00PM
Gene Regulatory Networks
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 5 of 5
Alexandre R. Colas, Sanford-Burnham Medical Research Institute, USA
Short Talk: Deciphering Cardiac Differentiation Using Whole Genome and 'Whole Combinome' miRNA Screening: Implications for Stem Cell Differentiation, Somatic Reprogramming and Cardiac Regeneration


Tuesday, March 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ptarmigan Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, March 03 | 7:30PM - 10:00PM
Poster Session 2
Room: Ptarmigan Ballroom
Poster sessions provide exciting opportunities for engagement between all levels of investigators. Abstracts beginning with X1 or X2 and the number 2 are featured during this poster session.

Wednesday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's/Ptarmigan B-C


Wednesday, March 04 | 8:00AM - 11:00AM
Cardiac Non-Myocytes in Tissue Structure and Function in the
Adult Heart

Room: Big Horn C

Speaker 1 of 6
* Merry L. Lindsey, University of Nebraska Medical Center., USA

Wednesday, March 04 | 8:00AM - 11:00AM
Cardiac Non-Myocytes in Tissue Structure and Function in the
Adult Heart

Room: Big Horn C

Speaker 2 of 6
Doris A. Taylor, Texas Heart Institute, USA
ECM Clues for Cardiac Re-Popularization: Lessons from the De-Cellularized Heart

Wednesday, March 04 | 8:00AM - 11:00AM
Cardiac Non-Myocytes in Tissue Structure and Function in the
Adult Heart

Room: Big Horn C

Speaker 3 of 6
Nadia A. Rosenthal, The Jackson Laboratory, USA
Immune Cell Regulation of Cardiac Regeneration

Wednesday, March 04 | 8:00AM - 11:00AM
Cardiac Non-Myocytes in Tissue Structure and Function in the
Adult Heart

Room: Big Horn C

Speaker 4 of 6
Shahin Rafii, Weill Cornell Medical College, USA
Angiocrine Contribution of the Vascular Niche to Regeneration and Fibrosis

Wednesday, March 04 | 8:00AM - 11:00AM
Cardiac Non-Myocytes in Tissue Structure and Function in the
Adult Heart

Room: Big Horn C

Speaker 5 of 6
Mario Delmar, New York University, USA
Heterocellular Mechanical Junctions and Arrhythmogenesis: A Visual Proteomics Approach to the Study of Intercellular Communication in the Heart

Wednesday, March 04 | 8:00AM - 11:00AM
Cardiac Non-Myocytes in Tissue Structure and Function in the
Adult Heart

Room: Big Horn C

Speaker 6 of 6
Manuel Mayr, King's College, University of London, UK
Short Talk: Glycoproteomics Analysis of the Human Cardiac Extracellular Matrix

Wednesday, March 04 | 8:00AM - 11:15AM
Renewal and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 1 of 7
* Kenneth D. Poss, Duke University Medical Center, USA


Wednesday, March 04 | 8:00AM - 11:15AM
Renewal and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 2 of 7
Nadia Mercader, Institut of Anatomy, University of Bern, Switzerland
Cellular and Molecular Mechanisms of Transient Cardiac Fibrosis followed by Heart Regeneration upon Cryoinjury in the Zebrafish


Wednesday, March 04 | 8:00AM - 11:15AM
Renewal and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 3 of 7
James F. Martin, Baylor College of Medicine, USA
Hippo-Signaling in Heart Regeneration


Wednesday, March 04 | 8:00AM - 11:15AM
Renewal and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 4 of 7
Gordana V. Vunjak-Novakovic, Columbia University, USA
Bioengineering Human Heart Tissue: Maturation and Utility for Drug Studies


Wednesday, March 04 | 8:00AM - 11:15AM
Renewal and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 5 of 7
Charles E. Murry, University of Washington, USA
Chromatin Signatures Identify Regulators of Cardiac Development


Wednesday, March 04 | 8:00AM - 11:15AM
Renewal and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 6 of 7
Sangita Choudhury, Boston Children's Hospital, USA
Short Talk: Identification of Novel Regulators of Cardiomyocyte Proliferation as Regenerative Therapies for Heart Failure


Wednesday, March 04 | 8:00AM - 11:15AM
Renewal and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 7 of 7
Michaela Patterson, University of Southern California, USA
Short Talk: Genetic Determinants of Adult Mammalian Heart Regeneration


Wednesday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Wednesday, March 04 | 11:00AM - 1:00PM
Poster Setup
Room: Ptarmigan Ballroom


Wednesday, March 04 | 11:00AM - 2:30PM
On Own for Lunch


Wednesday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Ptarmigan Ballroom


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Epigenetic and RNA Regulation of the Hetero-Cell
ular Heart
Room: Big Horn C

Speaker 1 of 10
* Manuel Mayr, King's College, University of London, UK

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Epigenetic and RNA Regulation of the Hetero-Cell
ular Heart
Room: Big Horn C

Speaker 2 of 10
* Katarzyna A. Cieslik, Baylor College of Medicine, USA

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Epigenetic and RNA Regulation of the Hetero-Cell
ular Heart
Room: Big Horn C

Speaker 3 of 10
Burcu Duygu, Maastricht University, Netherlands
Regulation of Pathological cardiac Remodeling following Myocardial Infarction: The Role of miR-199b

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Epigenetic and RNA Regulation of the Hetero-Cell
ular Heart
Room: Big Horn C

Speaker 4 of 10
Jan Fiedler, Hannover Medical School, Germany
Functional Relevance of Endothelial Hypoxia-Sensitive Long Non-Coding RNAs (lncRNAs)

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Epigenetic and RNA Regulation of the Hetero-Cell
ular Heart
Room: Big Horn C

Speaker 5 of 10
Jörg Heineke, Medizinische Hochschule Hannover, Germany
Impact of the Transcription Factor GATA2 in Endothelial Cells on Cardiac Failure through Regulation of Two Secreted Long Non-Coding RNAs

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Epigenetic and RNA Regulation of the Hetero-Cell
ular Heart
Room: Big Horn C

Speaker 6 of 10
Peng Zhang, Rhode Island Hospital and Alpert Medical School of Brown University, USA
A Novel Regulatory Role of MicroRNA-145 in Cardiac Fibroblasts

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Epigenetic and RNA Regulation of the Hetero-Cell
ular Heart
Room: Big Horn C

Speaker 7 of 10
Stephane Heymans, Maastricht University Medical Centre, Netherlands
MicroRNA-146a Rewires Cardiac Metabolism and causes Cardiac Dysfunction in Hypertensive Heart Disease

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Epigenetic and RNA Regulation of the Hetero-Cell
ular Heart
Room: Big Horn C

Speaker 8 of 10
Hyun Kook, Chonnam National University, South Korea
Posttranslational Modifications of Histone Deacetylase 2 in Cardiac Hypertrophy

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Epigenetic and RNA Regulation of the Hetero-Cell
ular Heart
Room: Big Horn C

Speaker 9 of 10
Jesung Moon, University of Texas Southwestern Medical Center, USA
Improving Adult Muscle Tissue Regeneration Using Small Molecule Antagonists of
Wnt-Mediated Signaling


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Epigenetic and RNA Regulation of the Hetero-Cell
ular Heart
Room: Big Horn C

Speaker 10 of 10
Emily K. Pugach, University of Colorado, USA
Cre Expression Driven by the alpha-Myosin Heavy Chain Promoter Induces DNA Damage and Cardiotoxicity

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Disease Models, Regeneration and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 1 of 9
* Jeroen Bakkers, Hubrecht Institute, Netherlands


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Disease Models, Regeneration and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 2 of 9
* Charles E. Murry, University of Washington, USA


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Disease Models, Regeneration and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 3 of 9
Mauro W. Costa, USA
A Novel Understanding of a Complex Disease: The Interplay of Congenital Heart Disease and Obesity


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Disease Models, Regeneration and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 4 of 9
Gaetano D'Amato, Centro Nacional de Investigaciones Cardiovasculares CNIC, Spain
Sequential Notch Activation Underlies Ventricular Chamber Development


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Disease Models, Regeneration and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 5 of 9
Diane Fatkin, Victor Chang Cardiac Research Institute, Australia
Genetic Variants in the Left-Right Asymmetry Gene LEFTY2 May Contribute to AF Susceptibility


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Disease Models, Regeneration and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 6 of 9
C. Geoffrey Burns, Harvard Medical School, Massachusetts General Hospital, USA
The AP-1 Transcription Factor Component Fosl2 Potentiates Myocardial Differentiation from the Zebrafish Second Heart Field


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Disease Models, Regeneration and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 7 of 9
Ge Tao, Baylor College of Medicine, USA
Paired-Like Homeodomain Transcription Factor 2 Promotes Mouse Myocardial Regeneration


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Disease Models, Regeneration and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 8 of 9
Christina V. Theodoris, University of California, San Francisco, USA
iPSC-Based Modeling of Human NOTCH1 Mutations Reveals Novel Pathways Regulating Aortic Valve Disease


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Disease Models, Regeneration and Plasticity
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 9 of 9
Chi-Chung Wu, Ulm University, Germany
BMP Signaling Is Essential for Zebrafish Heart Regeneration


Wednesday, March 04 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Wednesday, March 04 | 5:00PM - 7:00PM
Cardiac Non-Myocytes as Targets of Interventions
Room: Big Horn C

Speaker 1 of 5
* Thomas Thum, Medical School Hannover, Germany

Wednesday, March 04 | 5:00PM - 7:00PM
Cardiac Non-Myocytes as Targets of Interventions
Room: Big Horn C

Speaker 2 of 5
Stefan Engelhardt, Technical University of Munich, Germany
miRNAs as Modulators of Cardiac Fibrosis: Myocyte–Fibroblast Cross-Talk

Wednesday, March 04 | 5:00PM - 7:00PM
Cardiac Non-Myocytes as Targets of Interventions
Room: Big Horn C

Speaker 3 of 5
John A. Baugh, University College Dublin, Ireland
Short Talk: Epigenetic Therapy for the Treatment of Cardiac Hypertrophy and Fibrosis

Wednesday, March 04 | 5:00PM - 7:00PM
Cardiac Non-Myocytes as Targets of Interventions
Room: Big Horn C

Speaker 4 of 5
Natalia Trayanova, Johns Hopkins University, USA
Image-Based Computer Modeling of Cardiac Scar Effects and their Interventional Correction

Wednesday, March 04 | 5:00PM - 7:00PM
Cardiac Non-Myocytes as Targets of Interventions
Room: Big Horn C

Speaker 5 of 5
Bernd K. Fleischmann, Bonn University, Germany
Modulating the Myocardial Scar and Anti-Arrhythmogenesis

Wednesday, March 04 | 5:00PM - 7:00PM
Signaling Pathways: Integration and Crosstalk
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 1 of 5
* Stacey L. Rentschler, Washington University School of Medicine, USA


Wednesday, March 04 | 5:00PM - 7:00PM
Signaling Pathways: Integration and Crosstalk
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 2 of 5
Steven J. Kattman, USA
Harnessing Cardiac Development for Cell Manufacturing


Wednesday, March 04 | 5:00PM - 7:00PM
Signaling Pathways: Integration and Crosstalk
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 3 of 5
Katherine E. Yutzey, Cincinnati Children's Hospital Medical Center, USA
Regulation of Postnatal Cardiomyocyte Proliferation


Wednesday, March 04 | 5:00PM - 7:00PM
Signaling Pathways: Integration and Crosstalk
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 4 of 5
Jonathan A. Epstein, University of Pennsylvania, USA
Cardiac Myocyte Lineage Commitment


Wednesday, March 04 | 5:00PM - 7:00PM
Signaling Pathways: Integration and Crosstalk
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 5 of 5
Gabriele D'Uva, Weizmann Institute of Science, Israel
Short Talk: ERBB2 Triggers Mammalian Heart Regeneration by Promoting Cardiomyocyte Dedifferentiation and Proliferation


Wednesday, March 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ptarmigan Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's/Ptarmigan B-C


Thursday, March 05 | 8:00AM - 11:00AM
Responses to Cardiac Injury: Who Does What?
Room: Big Horn C

Speaker 1 of 6
* Nadia A. Rosenthal, The Jackson Laboratory, USA

Thursday, March 05 | 8:00AM - 11:00AM
Responses to Cardiac Injury: Who Does What?
Room: Big Horn C

Speaker 2 of 6
Richard T. Lee, Harvard University, USA
Nerve Dependence of Cardiac Regeneration

Thursday, March 05 | 8:00AM - 11:00AM
Responses to Cardiac Injury: Who Does What?
Room: Big Horn C

Speaker 3 of 6
Merry L. Lindsey, University of Nebraska Medical Center., USA
Proteomics of Post-Infarct Extracellular Matrix Remodeling

Thursday, March 05 | 8:00AM - 11:00AM
Responses to Cardiac Injury: Who Does What?
Room: Big Horn C

Speaker 4 of 6
Joshua M. Hare, University of Miami Miller School of Medicine, USA
Therapeutic Stem Cell Interactions for Heart Disease

Thursday, March 05 | 8:00AM - 11:00AM
Responses to Cardiac Injury: Who Does What?
Room: Big Horn C

Speaker 5 of 6
Jeffrey W. Holmes, University of Virginia, USA
Scar Structure and Mechanics: Therapeutic Implications of Fibroblast Mechanosensitivity

Thursday, March 05 | 8:00AM - 11:00AM
Responses to Cardiac Injury: Who Does What?
Room: Big Horn C

Speaker 6 of 6
Jennifer M. Davis, Cincinnati Children's Hospital Medical Center, USA
Short Talk: MBNL1 Globally Regulates the Maturation of mRNAs that Promote Cellular Differentiation Programs

Thursday, March 05 | 8:00AM - 11:15AM
Morphogenesis and Biomechanics
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 1 of 7
* Katherine E. Yutzey, Cincinnati Children's Hospital Medical Center, USA


Thursday, March 05 | 8:00AM - 11:15AM
Morphogenesis and Biomechanics
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 2 of 7
Hiroshi Hamada, Osaka University, Japan
Role of Cilia and Fluid Flow in Left-Right Symmetry Breaking


Thursday, March 05 | 8:00AM - 11:15AM
Morphogenesis and Biomechanics
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 3 of 7
Deborah L. Yelon, University of California, San Diego, USA
Extracellular Interactions that Sculpt Cardiac Morphology


Thursday, March 05 | 8:00AM - 11:15AM
Morphogenesis and Biomechanics
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 4 of 7
Jeroen Bakkers, Hubrecht Institute, Netherlands
Mechanisms Driving Cardiac Left-Right Asymmetry


Thursday, March 05 | 8:00AM - 11:15AM
Morphogenesis and Biomechanics
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 5 of 7
Robert Fischer, NHLBI, National Institutes of Health, USA
Shaping Endothelial Cells by Curvature Regulation


Thursday, March 05 | 8:00AM - 11:15AM
Morphogenesis and Biomechanics
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 6 of 7
Jay W. Schneider, University of Texas Southwestern Medical Center, USA
Short Talk: Cardiac Regeleration: Robust, Versatile and Tunable Myocardial Responses to Implanted Biomaterial Hydrogels


Thursday, March 05 | 8:00AM - 11:15AM
Morphogenesis and Biomechanics
This session is from Heart Disease and Regeneration
Room: Big Horn B

Speaker 7 of 7
Alexia Vite, Thomas Jefferson University, USA
Short Talk: Role of Cytoskeletal Tension in the Regulation of Yap Activity in the Heart


Thursday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Thursday, March 05 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, March 05 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Thursday, March 05 | 5:00PM - 6:45PM
Heart Repair: Make New Muscle or Better Scars? (Joint)
Room: Big Horn B

Speaker 1 of 5
* Peter Kohl, University of Freiburg, Germany

Thursday, March 05 | 5:00PM - 6:45PM
Heart Repair: Make New Muscle or Better Scars? (Joint)
Room: Big Horn B

Speaker 2 of 5
* Deborah L. Yelon, University of California, San Diego, USA

Thursday, March 05 | 5:00PM - 6:45PM
Heart Repair: Make New Muscle or Better Scars? (Joint)
Room: Big Horn B

Speaker 3 of 5
Kenneth D. Poss, Duke University Medical Center, USA
Natural Cardiac Repair Strategies

Thursday, March 05 | 5:00PM - 6:45PM
Heart Repair: Make New Muscle or Better Scars? (Joint)
Room: Big Horn B

Speaker 4 of 5
Paul R. Riley, University of Oxford, UK
Epigenetic Reactivation of Adult Epicardium Underpins Endogenous Heart Repair

Thursday, March 05 | 5:00PM - 6:45PM
Heart Repair: Make New Muscle or Better Scars? (Joint)
Room: Big Horn B

Speaker 5 of 5
Roger R. Markwald, Medical University of South Carolina, USA
The Living Scar: Engineering to Benefit Patient Health

Thursday, March 05 | 6:45PM - 7:30PM
Keynote Address (Joint)
Room: Big Horn B

Speaker 1 of 1
Stefanie Dimmeler, University of Frankfurt, Germany
Noncoding RNAs and Cardiac Repair

Thursday, March 05 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Big Horn C
No registration fees are used to fund alcohol served at this function.

Thursday, March 05 | 8:30PM - 11:00PM
Entertainment
Room: Big Horn C
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 05 | 8:30PM - 11:00PM
Cash Bar
Room: Big Horn C


Friday, March 06 | 10:25AM - 10:25AM
Departure


*Session Chair.