Web Desc
DNA Replication and Recombination
joint with Genomic Instability and DNA Repair
Organizer(s): Simon J. Boulton, Karlene A. Cimprich and Stephen D. Bell
Date: March 01 - 06, 2015
Location: Whistler Conference Centre, Whistler, BC, Canada
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
DNA replication is a fundamental process for all cells and as such is subject to exquisite cell cycle control and integration with other key cellular processes. In particular, faithful genome duplication is critically dependent on homologous recombination, which serves to protect stalled replication forks and to facilitate restart of DNA synthesis following replication fork stalling/collapse. Failure to execute replication, repair or recombination effectively is a major source of genome instability in cells, which lies at the heart of cancer and aging in humans. Although recent advances have improved our understanding of a number of the key steps and transactions that govern DNA replication and recombination, our knowledge of the pathways that coordinate replication and repair remains incomplete. Given the intimate relationship between DNA replication and recombination and their importance for genome stability, this meeting will be held jointly with the Keystone Symposia meeting on 'Genomic Stability and DNA Repair.' These concurrent meetings will provide a unique forum for interdisciplinary discussions by bringing together leading experts in these areas with a shared keynote address and two joint plenary sessions. Joint sessions will be interspersed with specific topic sessions, workshops and poster sessions that have been selected to highlight the latest advances in our understanding of the mechanisms governing DNA replication and recombination, the emerging interconnections between these fields, the various multidisciplinary approaches that are currently driving the field forward and the challenges that remain to be investigated.
Scholarship Deadline: November 5 2014
Discounted Abstract Deadline: November 5 2014
Abstract Deadline: December 4 2014
Discounted Registration Deadline: January 7 2015
Abstacts when book is in proofing process


We gratefully acknowledge additional support for this conference from:
Bethyl Laboratories, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
PLOS
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 01 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sea to Sky Foyer


Sunday, March 01 | 6:00PM - 8:00PM
Welcome Mixer
Room: Sea to Sky Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Monday, March 02 | 7:30AM - 8:00AM
Poster Setup
Room: Sea to Sky A


Monday, March 02 | 8:00AM - 5:00PM
Poster Viewing
Room: Sea to Sky A


Monday, March 02 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 1 of 4
* Simon J. Boulton, Francis Crick Institute, UK

Monday, March 02 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 2 of 4
* Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada

Monday, March 02 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 3 of 4
Stephen P. Jackson, University of Cambridge, UK
Assembly and Disassembly of Protein Complexes at Sites of DNA Damage

Monday, March 02 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 4 of 4
John F.X. Diffley, Francis Crick Institute, UK
Right Place, Right Time: Eukaryotic DNA Replication Mechanism and Regulation

Monday, March 02 | 9:30AM - 10:00AM
Coffee Break
Room: Foyer


Monday, March 02 | 10:00AM - 12:15PM
Initiation and/or Helicase Activation
Room: Sea to Sky B

Speaker 1 of 6
* Simon J. Boulton, Francis Crick Institute, UK

Monday, March 02 | 10:00AM - 12:15PM
Initiation and/or Helicase Activation
Room: Sea to Sky B

Speaker 2 of 6
Stephen D. Bell, Indiana University, USA
Archaeal DNA Replication Initiator Proteins

Monday, March 02 | 10:00AM - 12:15PM
Initiation and/or Helicase Activation
Room: Sea to Sky B

Speaker 3 of 6
Daniel Duzdevich, Columbia University, USA
Short Talk: The Dynamics of Eukaryotic Replication Initiation: Origin Specificity, Licensing and Firing at the Single-Molecule Level

Monday, March 02 | 10:00AM - 12:15PM
Initiation and/or Helicase Activation
Room: Sea to Sky B

Speaker 4 of 6
Michael E. O'Donnell, Rockefeller University, USA
Architecture and Function of the Eukaryotic Replisome

Monday, March 02 | 10:00AM - 12:15PM
Initiation and/or Helicase Activation
Room: Sea to Sky B

Speaker 5 of 6
James M. Berger, Johns Hopkins University School of Medicine, USA
Bending, Twisting, Popping: Protein and Nucleic-Acid Remodeling by ATP-Dependent Machines and Switches

Monday, March 02 | 10:00AM - 12:15PM
Initiation and/or Helicase Activation
Room: Sea to Sky B

Speaker 6 of 6
Aline C. Simon, University of Cambridge, UK
Short Talk: Structure of Human Cdc45 and its Interactions within the CMG Helicase Complex

Monday, March 02 | 10:00AM - 12:15PM
Animal Models and Syndromes
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 1 of 6
* André Nussenzweig, NCI, National Institutes of Health, USA


Monday, March 02 | 10:00AM - 12:15PM
Animal Models and Syndromes
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 2 of 6
Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Regulation of Homologous Recombination in Vertebrates


Monday, March 02 | 10:00AM - 12:15PM
Animal Models and Syndromes
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 3 of 6
Jos Jonkers, Netherlands Cancer Institute, Netherlands
BRCA1 Deficiency in Pre-Clinical Models


Monday, March 02 | 10:00AM - 12:15PM
Animal Models and Syndromes
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 4 of 6
Agata Smogorzewska, Rockefeller University, USA
Molecular Genetics of Fanconi Anemia


Monday, March 02 | 10:00AM - 12:15PM
Animal Models and Syndromes
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 5 of 6
Bing Xia, Rutgers Cancer Institute of New Jersey, USA
Functional and Mutational Landscape of BRCA1 for Homology-Directed Repair and Drug Resistance


Monday, March 02 | 10:00AM - 12:15PM
Animal Models and Syndromes
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 6 of 6
Uri Tabori, Hospital for Sick Children, Canada
Short Talk: Combined Hereditary and Somatic Mutations of Replication Error Repair Result in Rapid Onset of Ultra Hypermutated Cancers


Monday, March 02 | 12:15PM - 1:15PM
Lunch
Room: Sea to Sky A


Monday, March 02 | 12:45PM - 3:15PM
Poster Session 1
Room: Sea to Sky A


Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 1 of 8
* Maria Jasin, Memorial Sloan Kettering Cancer Center, USA


Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 2 of 8
James K. Nuñez, University of California, San Francisco, USA
Integrase-Mediated Spacer Acquisition during CRISPR–Cas Adaptive Immunity


Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 3 of 8
Cecilia Cotta-Ramusino, Tessera Therapeutic, USA
Gene Targeting of the HBB Locus by Crispr/Cas9 to Investigate Repair Pathway Choice in Response to Different Types of DNA Lesions


Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 4 of 8
Jordan B. Pinder, Dalhousie University, Canada
Enhancing Efficiency of Cas9-Stimulated Homology-Directed Repair


Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 5 of 8
Megan van-Overbeek, Caribou Biosciences, Inc., USA
Methods to Enhance Homology-Directed Repair at CRISPR-Cas9 Induced Double-Strand Breaks


Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 6 of 8
Jeremy M. Stark, Beckman Research Institute of the City of Hope, USA
DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining


Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 7 of 8
Bernard S. Lopez, Institut Gustave Roussy, France
The Joining of Distal Double-Strand Breaks Favors Complex Alternative End-Joining Rearrangements; Impact of the Cohesin Complex on the Joining of Distant Double Strand Ends


Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 8 of 8
Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology, France
Double Strand Break Repair within Heterochromatin, Revealed with the CRISPR/Cas9 System


Monday, March 02 | 5:00PM - 5:30PM
Coffee Available
Room: Foyer


Monday, March 02 | 5:30PM - 7:30PM
Structural and Single-Molecule Analysis of Replication/Repai
r

Room: Sea to Sky B

Speaker 1 of 5
* Alessandro Costa, Francis Crick Institute, UK

Monday, March 02 | 5:30PM - 7:30PM
Structural and Single-Molecule Analysis of Replication/Repai
r

Room: Sea to Sky B

Speaker 2 of 5
Antoine M. van Oijen, University of Wollongong, Australia
Single-Molecule Studies of DNA Replication: The Plasticity of the Replisome

Monday, March 02 | 5:30PM - 7:30PM
Structural and Single-Molecule Analysis of Replication/Repai
r

Room: Sea to Sky B

Speaker 3 of 5
Thomas A. Steitz, Howard Hughes Medical Institute, Yale University, USA
The Macromolecular Replicating Machinery of Bacteria: Structural Insights into the Replisome

Monday, March 02 | 5:30PM - 7:30PM
Structural and Single-Molecule Analysis of Replication/Repai
r

Room: Sea to Sky B

Speaker 4 of 5
Franziska Bleichert, Johns Hopkins University School of Medicine, USA
Short Talk: Structural Investigations of the Eukaryotic Origin Recognition Complex

Monday, March 02 | 5:30PM - 7:30PM
Structural and Single-Molecule Analysis of Replication/Repai
r

Room: Sea to Sky B

Speaker 5 of 5
Stephen C. Kowalczykowski, University of California, Davis, USA
Visualizing Recombination and Replication on Single Molecules of DNA

Monday, March 02 | 5:30PM - 7:30PM
Telomeres, Aging and Stem Cells
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 1 of 5
* Agata Smogorzewska, Rockefeller University, USA


Monday, March 02 | 5:30PM - 7:30PM
Telomeres, Aging and Stem Cells
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 2 of 5
Titia de Lange, Rockefeller University, USA
The LINC Complex Mediates 53BP1-Driven DSB Mobility and Non-Homologous End Joining


Monday, March 02 | 5:30PM - 7:30PM
Telomeres, Aging and Stem Cells
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 3 of 5
Emmanuelle Passegué, Columbia University, USA
DNA Repair in Stem Cells


Monday, March 02 | 5:30PM - 7:30PM
Telomeres, Aging and Stem Cells
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 4 of 5
Jan Karlseder, The Salk Institute for Biological Studies, USA
Cell Death during Crisis Is Mediated by Mitotic Telomere Deprotection


Monday, March 02 | 5:30PM - 7:30PM
Telomeres, Aging and Stem Cells
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 5 of 5
Madalena Tarsounas, University of Oxford, UK
Short Talk: BRCA2 Prevents G-Quadruplex-Induced Replication Stress and Chromosomal Breakage


Monday, March 02 | 7:30PM - 7:30PM
On Own for Dinner


Tuesday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 1 of 7
* John H.J. Petrini, Memorial Sloan-Kettering Cancer Center, USA

Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 2 of 7
John Rouse, University of Dundee, UK
Dissecting the Roles and Regulation of Nucleases Involved in ICL Repair

Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 3 of 7
Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada
Cell Cycle Regulation of DNA Double-Strand Break Repair

Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 4 of 7
Simon J. Boulton, Francis Crick Institute, UK
Rad51 Paralogs Remodel Pre-Synaptic Rad51 Filaments to Stimulate Homologous Recombination


Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 5 of 7
Stephen C. West, Francis Crick Institute, UK
Defective DNA Strand Break Repair and Links to Genome Instability and Cancer

Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 6 of 7
Kata Sarlós, University of Copenhagen, Denmark
Short Talk: In vitro Reconstitution of Anaphase Bridge Decatenation Pathways

Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 7 of 7
Ralph Scully, Beth Israel Deaconess Medical Center, USA
Short Talk: Recombination Control at Tus/Ter-Stalled Mammalian Replication Forks: The Good, the Bad and the Ugly

Tuesday, March 03 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, March 03 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Tuesday, March 03 | 11:15AM - 2:30PM
On Own for Lunch


Tuesday, March 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky B

Speaker 1 of 9
* Alessandro Vindigni, St. Louis University, USA

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky B

Speaker 2 of 9
Jacques Côté, Laval University Cancer Research Center, Canada
Dynamic Acetylation of PCNA Sliding Surface Differentially Regulates Distinct DNA Polymerases to Promote Genome Stability

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky B

Speaker 3 of 9
Anne D. Donaldson, University of Aberdeen, UK
Replication-Coupled PCNA Unloading by the Elg1 Complex Requires Okazaki Fragment Ligation

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky B

Speaker 4 of 9
Bojk A. Berghuis, Delft University of Technology, Netherlands
Strand Separation Suffices to Establish a Long-Lived, Foolproof DNA-Protein Lock at the Tus-Ter Replication Fork Barrier

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky B

Speaker 5 of 9
Claus Storgaard Sørensen, University of Copenhagen, Denmark
A Novel Mechanism Linking CDC6 Protein Stability, DNA Replication and Genome Integrity

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky B

Speaker 6 of 9
Nynke H. Dekker, Delft University of Technology, Netherlands
Dynamics of Replisome Stoichiometry and Termination Studied at the Single Cell Level

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky B

Speaker 7 of 9
Daniel L. Kaplan, Florida State University College of Medicine, USA
The Dbf4-Cdc7 Kinase Promotes Mcm2-7 Ring Opening to Allow for Single-Stranded DNA Extrusion and Helicase Assembly

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky B

Speaker 8 of 9
Samual D. Dick, Cancer Research UK-London Research Institute, UK
Structural Basis for Activation of Cdc7 Kinase and its Substrate Recognition

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky B

Speaker 9 of 9
Dirk Remus, Memorial Sloan-Kettering Cancer Center, USA
Mcm2-7 Double Hexamer Mobility Allows Redistribution of Replication Origins by Elongating RNA Polymerase

Tuesday, March 03 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, March 03 | 5:00PM - 7:00PM
Repair/Replication Interface
Room: Sea to Sky B

Speaker 1 of 5
* Wolf-Dietrich Heyer, University of California, Davis, USA

Tuesday, March 03 | 5:00PM - 7:00PM
Repair/Replication Interface
Room: Sea to Sky B

Speaker 2 of 5
Karlene A. Cimprich, Stanford University, USA
Mechanisms for the Maintenance of Genome Stability

Tuesday, March 03 | 5:00PM - 7:00PM
Repair/Replication Interface
Room: Sea to Sky B

Speaker 3 of 5
Houra Merrikh, Vanderbilt University, USA
Direct Visualization of DNA Replication Conflicts in the Bacterial Cell

Tuesday, March 03 | 5:00PM - 7:00PM
Repair/Replication Interface
Room: Sea to Sky B

Speaker 4 of 5
Jade Wang, University of Wisconsin-Madison, USA
Interplay between Transcription and Replication Machineries

Tuesday, March 03 | 5:00PM - 7:00PM
Repair/Replication Interface
Room: Sea to Sky B

Speaker 5 of 5
Francesca Storici, Georgia Institute of Technology, USA
Short Talk: Double-Strand Break Repair with Transcript RNA

Tuesday, March 03 | 5:00PM - 7:00PM
Mitotic Progression and DNA Damage
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 1 of 5
* Stephen J. Elledge, Harvard Medical School, USA


Tuesday, March 03 | 5:00PM - 7:00PM
Mitotic Progression and DNA Damage
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 2 of 5
David Pellman, Dana-Farber Cancer Institute, USA
Chromothripsis and other Complex Chromosomal Rearrangements from an Error in Mitosis


Tuesday, March 03 | 5:00PM - 7:00PM
Mitotic Progression and DNA Damage
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 3 of 5
Peter Campbell, Wellcome Trust Sanger Institute, UK
Interrogating the Architecture of Cancer Genomes


Tuesday, March 03 | 5:00PM - 7:00PM
Mitotic Progression and DNA Damage
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 4 of 5
Jiri Lukas, Novo Nordisk Foundation Center for Protein Research, Denmark
Limits and Thresholds of Repair Pathway Choices during the Cell Cycle


Tuesday, March 03 | 5:00PM - 7:00PM
Mitotic Progression and DNA Damage
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 5 of 5
A. John Callegari, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Mutagenic Translesion Polymerases Are Required to Replicate Damaged DNA after the G2/M Checkpoint


Tuesday, March 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Tuesday, March 03 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Wednesday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 1 of 7
* Jiri Lukas, Novo Nordisk Foundation Center for Protein Research, Denmark

Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 2 of 7
Roger Greenberg, University of Pennsylvania, USA
Impact of DNA Damage Responses on Higher Order Chromatin Structure

Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 3 of 7
Anja Groth, University of Copenhagen, Denmark
Chromatin Replication and Epigenome Maintenance

Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 4 of 7
Iestyn Whitehouse, Memorial Sloan Kettering Cancer Center, USA
Chromatin Assembly and Lagging Strand Synthesis

Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 5 of 7
Michelle Debatisse, Institut Curie, France
Respective Roles of Replication and Transcription in Common Fragile Site Instability

Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 6 of 7
Caroline B. Strømme, Biotech Research and Innovation Centre, Denmark
Short Talk: MCM2 Mimics Nucleosomal DNA to Chaperone Canonical and Variant Histones H3-H4

Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 7 of 7
Sophie E. Polo, Paris Diderot University, France
Short Talk: New Insights into Epigenome Maintenance in Response to DNA Damage by Real-Time Tracking of Histone Dynamics in Human Cells

Wednesday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, March 04 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Wednesday, March 04 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 1 of 9
* J. Ross Chapman, University of Oxford, UK


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 2 of 9
Raphael Ceccaldi, Dana-Farber Cancer Institute, USA
Homologous Recombination (HR)-Deficient Tumors Are Hyper-Dependent on POLQ-Mediated Repair


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 3 of 9
Pedro A. Mateos-Gomez, New York University, USA
Mammalian Polymerase Theta Promotes Alternative-NHEJ and Suppresses Recombination


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 4 of 9
Saskia Hoffmann, University of Copenhagen, Denmark
TRAIP Is a new PCNA Ubiquitin Ligase in the DNA Damage Response


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 5 of 9
Michael Huen, University of Hong Kong, Hong Kong
A PCNA Clamp Unloader at Stressed Replication Forks


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 6 of 9
Kyle M. Miller, USA
Screen Identifies Role for Bromodomain Chromatin Reader Proteins in the DNA Damage Response


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 7 of 9
Stephan Uphoff, University of Oxford, UK
Stochastic Activation of a DNA Damage Response by a Single Repair Event


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 8 of 9
Laura W. Dillon, NHLBI, National Institutes of Health, USA
Extrachromosomal microDNAs in Vertebrate Tissues Arise from Areas with Active Chromatin Marks and High Exon Density by Mismatch Repair and Other Repair Pathways


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 9 of 9
Markus Löbrich, Darmstadt University of Technology, Germany
Nek1 Phoshorylates Rad54 to Promote Homologous Recombination


Wednesday, March 04 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 04 | 5:00PM - 7:00PM
Double-Strand Break Repair Metabolism
Room: Sea to Sky B

Speaker 1 of 5
* John Rouse, University of Dundee, UK

Wednesday, March 04 | 5:00PM - 7:00PM
Double-Strand Break Repair Metabolism
Room: Sea to Sky B

Speaker 2 of 5
Dale B. Wigley, Institute of Cancer Research, UK
Structural Insights into Double-Strand Break Processing by AddAB

Wednesday, March 04 | 5:00PM - 7:00PM
Double-Strand Break Repair Metabolism
Room: Sea to Sky B

Speaker 3 of 5
John H.J. Petrini, Memorial Sloan-Kettering Cancer Center, USA
ATM Independent Functions of the Mre11 Complex

Wednesday, March 04 | 5:00PM - 7:00PM
Double-Strand Break Repair Metabolism
Room: Sea to Sky B

Speaker 4 of 5
Gaelle Legube, Center for Integrative Biology, France
Functions of chromatin during DNA Double-Strand break repair

Wednesday, March 04 | 5:00PM - 7:00PM
Double-Strand Break Repair Metabolism
Room: Sea to Sky B

Speaker 5 of 5
Irene Chiolo, University of Southern California, USA
Short Talk: Heterochromatic Breaks Move to the Nuclear Periphery to Complete Recombinational Repair

Wednesday, March 04 | 5:00PM - 7:00PM
Genome Integrity in the Immune System
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 1 of 5
* Alberto Martin, University of Toronto, Canada


Wednesday, March 04 | 5:00PM - 7:00PM
Genome Integrity in the Immune System
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 2 of 5
André Nussenzweig, NCI, National Institutes of Health, USA
DNA-Damage-Induced Differentiation of Leukaemic Cells as an Anti-Cancer Barrier


Wednesday, March 04 | 5:00PM - 7:00PM
Genome Integrity in the Immune System
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 3 of 5
Frederick W. Alt, Boston Children's Hospital, USA
Convergent Sense/Antisense Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability


Wednesday, March 04 | 5:00PM - 7:00PM
Genome Integrity in the Immune System
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 4 of 5
Shan Zha, Columbia University Medical Center, USA
Short Talk: DNA-PKcs Phosphorylation as the Molecular Switch for End-Processing and End-Ligation during NHEJ


Wednesday, March 04 | 5:00PM - 7:00PM
Genome Integrity in the Immune System
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 5 of 5
Jeremy A. Daniel, University of Copenhagen, Denmark
Short Talk: A PTIP-PA1 Subcomplex Promotes Transcription for IgH Class-Switching Independently from the associated MLL3-MLL4 Methyltransferase Complex


Wednesday, March 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Wednesday, March 04 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky A


Thursday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Thursday, March 05 | 8:00AM - 11:15AM
Replication Coupled Repair
Room: Sea to Sky B

Speaker 1 of 7
* Stephen D. Bell, Indiana University, USA

Thursday, March 05 | 8:00AM - 11:15AM
Replication Coupled Repair
Room: Sea to Sky B

Speaker 2 of 7
Kenneth J. Marians, Memorial Sloan Kettering Cancer Center, USA
Replication Restart and Lesion Bypass

Thursday, March 05 | 8:00AM - 11:15AM
Replication Coupled Repair
Room: Sea to Sky B

Speaker 3 of 7
Johannes C. Walter, Harvard Medical School, USA
The Mechanism of Vertebrate Replication Termination

Thursday, March 05 | 8:00AM - 11:15AM
Replication Coupled Repair
Room: Sea to Sky B

Speaker 4 of 7
Johanne Murray, University of Sussex, UK
Recombination-Dependent Replication Restart Generates Chromosome Rearrangements

Thursday, March 05 | 8:00AM - 11:15AM
Replication Coupled Repair
Room: Sea to Sky B

Speaker 5 of 7
Philippe Pasero, Institute of Human Genetics, France
The HIV Restriction Factor SAMHD1 Processes Stalled Replication Forks

Thursday, March 05 | 8:00AM - 11:15AM
Replication Coupled Repair
Room: Sea to Sky B

Speaker 6 of 7
Alessandro Vindigni, St. Louis University, USA
Short Talk: Distinct Roles of Human Nucleases in Replication Stress Response

Thursday, March 05 | 8:00AM - 11:15AM
Replication Coupled Repair
Room: Sea to Sky B

Speaker 7 of 7
Alessandro Costa, Francis Crick Institute, UK
Short Talk: A Reverse Sewing Machine in the Eukaryotic Replisome

Thursday, March 05 | 8:00AM - 11:15AM
DNA Repair Pathway Decisions
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 1 of 8
* Roger Greenberg, University of Pennsylvania, USA


Thursday, March 05 | 8:00AM - 11:15AM
DNA Repair Pathway Decisions
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 2 of 8
Lorraine S. Symington, Columbia University, USA
Sae2 Promotes DNA Damage Resistance by Removing the Mre11-Rad50-Xrs2 Complex from DNA and Attenuating Rad53 Signaling


Thursday, March 05 | 8:00AM - 11:15AM
DNA Repair Pathway Decisions
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 3 of 8
Gregory Ira, Baylor College of Medicine, USA
Mus81 Mediates a Switch from Error-Prone to High-Fidelity DNA Synthesis at Broken Replication Forks


Thursday, March 05 | 8:00AM - 11:15AM
DNA Repair Pathway Decisions
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 4 of 8
James E. Haber, Brandeis University, USA
Short Talk: Chromosome Architecture and Repair of Broken Chromosomes


Thursday, March 05 | 8:00AM - 11:15AM
DNA Repair Pathway Decisions
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 5 of 8
Stephen J. Elledge, Harvard Medical School, USA
A New Role for Ubiquitination in Genomic Stability through RFWD3


Thursday, March 05 | 8:00AM - 11:15AM
DNA Repair Pathway Decisions
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 6 of 8
Dipanjan Chowdhury, Dana-Farber Cancer Institute, Harvard Medical School, USA
Short Talk: Dephosphorylation a 'Priming Event' in Repair of DNA Double Strand Breaks


Thursday, March 05 | 8:00AM - 11:15AM
DNA Repair Pathway Decisions
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 7 of 8
Sven Rottenberg, University of Bern, Switzerland
Short Talk: REV7 Counteracts DNA Double-Strand Break Resection and its Loss causes PARP Inhibitor Resistance of BRCA1-Deficient Mammary Tumors


Thursday, March 05 | 8:00AM - 11:15AM
DNA Repair Pathway Decisions
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 8 of 8
Fabrizio d'Adda di Fagagna, IFOM, The FIRC Institute of Molecular Oncology, Italy
Short Talk: The Role of Non Coding RNA in the Control of DNA Damage Response


Thursday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, March 05 | 11:15AM - 2:30PM
On Own for Lunch


Thursday, March 05 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky B

Speaker 1 of 9
* Neil Hunter, University of California, Davis, USA

Thursday, March 05 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky B

Speaker 2 of 9
Gongshi Bai, Cornell University, USA
Studying DNA Replication Regulation in a Defective Replication Helicase Mouse Cancer Model

Thursday, March 05 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky B

Speaker 3 of 9
Fay A. Cooper, Institute of Genetics and Molecular Medicine, University of Edinburgh, UK
Human Mutations in ORC1 Disrupt Embryonic Growth in Zebrafish and Mice

Thursday, March 05 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky B

Speaker 4 of 9
Luis Ignacio Toledo, NNF Center for Protein Research, University of Copenhagen, Denmark
Mechanistic Framework of the Boundary between Replication Stress and Genome Disintegration

Thursday, March 05 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky B

Speaker 5 of 9
George Chung, University of British Columbia, Canada
The Molecular Identification of a Gene which Controls the Meiotic Recombination Landscape in Caenorhabditis elegans

Thursday, March 05 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky B

Speaker 6 of 9
George-Lucian Moldovan, Pennsylvania State College of Medicine, USA
The Role of Mono-ADP-Ribosylation in DNA Repair

Thursday, March 05 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky B

Speaker 7 of 9
Niek van Wietmarschen, NCI, National Institutes of Health, USA
Defined Recombination Hotspots in Bloom Syndrome Cells

Thursday, March 05 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky B

Speaker 8 of 9
Shunichi Takeda, Kyoto University, Japan
Collaboration of BRCA1, CtIP and Dna2 Is Required to Initiate Double-Strand Break Repair by Homologous Recombination

Thursday, March 05 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky B

Speaker 9 of 9
Katharina Schlacher, MD Anderson Cancer Center, USA
A Phosphatase-Independent PTEN Activity Controls 53BP1 Recruitment to Stalled Replication Forks for Replication Restart and Stability

Thursday, March 05 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, March 05 | 5:00PM - 6:45PM
Regulation of DSB Repair
Room: Sea to Sky B

Speaker 1 of 4
* Johanne Murray, University of Sussex, UK

Thursday, March 05 | 5:00PM - 6:45PM
Regulation of DSB Repair
Room: Sea to Sky B

Speaker 2 of 4
Wolf-Dietrich Heyer, University of California, Davis, USA
Mechanisms and Regulation of Homologous Recombination

Thursday, March 05 | 5:00PM - 6:45PM
Regulation of DSB Repair
Room: Sea to Sky B

Speaker 3 of 4
Scott Keeney, HHMI/Memorial Sloan Kettering Cancer Center, USA
Mechanism and Regulation of Meiotic Recombination Initiation

Thursday, March 05 | 5:00PM - 6:45PM
Regulation of DSB Repair
Room: Sea to Sky B

Speaker 4 of 4
Neil Hunter, University of California, Davis, USA
Local and Global Regulation of Meiotic Prophase by Post-Translational Protein Modification

Thursday, March 05 | 5:00PM - 6:45PM
Transcription, Ribonucleotides and Genome Integrity
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 1 of 4
* Fabrizio d'Adda di Fagagna, IFOM, The FIRC Institute of Molecular Oncology, Italy


Thursday, March 05 | 5:00PM - 6:45PM
Transcription, Ribonucleotides and Genome Integrity
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 2 of 4
Andrés Aguilera, University of Seville, CABIMER, Spain
Connecting R-Loop- and Transcription-Mediated Genome Instability with Chromatin Reorganization and Replication Stress


Thursday, March 05 | 5:00PM - 6:45PM
Transcription, Ribonucleotides and Genome Integrity
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 3 of 4
Josef Jiricny, University of Zurich, Switzerland
Ribonucleotides Misincorporated into DNA Act as Strand-Discrimination Signals in Eukaryotic Mismatch Repair


Thursday, March 05 | 5:00PM - 6:45PM
Transcription, Ribonucleotides and Genome Integrity
This session is from Genomic Instability/DNA Repair
Room: Sea to Sky C

Speaker 4 of 4
Jesper Q. Svejstrup, Francis Crick Institute, UK
Transcription Stress-Induced Genome Instability


Thursday, March 05 | 6:45PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: See to Sky B


Thursday, March 05 | 6:45PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Genomic Instability/DNA Repair
Room: See to Sky C


Thursday, March 05 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Thursday, March 05 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 05 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Friday, March 06 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.