Web Desc
HIV Vaccines
joint with The Golden Anniversary of B Cell Discovery
Organizer(s): Giuseppe Pantaleo, Rafick P. Sekaly and Leonidas Stamatatos
Date: March 22 - 27, 2015
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by Merck & Co., Inc. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
For important information on the coronavirus, please click here
Summary of Meeting:
As the 30th anniversary of the discovery of HIV has come and gone, HIV remains a catastrophic public health concern, with an estimated global prevalence of 34 million HIV-infected persons. Despite the remarkable advances in the development of several biomedical interventions for the prevention of HIV, the importance of developing an effective HIV vaccine has been recognized by a wide spectrum of the scientific community and civil society. Important milestones for the HIV vaccine field were the demonstration that a vaccine regimen could reduce HIV acquisition and the identification of binding IgG envelope (env) antibodies as potential correlates of protection from HIV acquisition. However, broad neutralizing antibodies (bNAbs) are thought to be the main mechanism of protection of the currently available effective vaccines. This meeting addresses the major scientific gaps in the generation of env bNAbs. Major areas covered by the meeting include: 1) Understanding the development of bNAbs in natural infections and following vaccination; 2) Determining predictors of response to vaccines; 3) Reviewing advances in envelope immunogen design; 4) The therapeutic use of bNAbs; 5) The application of novel technologies to monitor the immune response; and 6) The development of therapeutic strategies aimed to functional HIV cure. The meeting will bring together interdisciplinary groups with outstanding expertise in B- and T-cell biology, structural biology, vaccinology and clinical science. It will therefore provide insight into the attendees how innovative basic observations from the bench side may translate into the clinical development of vaccines and therapeutic interventions.
Global Health Travel Award Deadline: October 21 2014
Scholarship Deadline: November 19 2014
Discounted Abstract Deadline: November 19 2014
Abstract Deadline: December 17 2014
Discounted Registration Deadline: January 20 2015
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates FoundationMerck & Co., Inc.
We gratefully acknowledge additional support for this conference from:
Canadian HIV Vaccine Initiative ResearchMabtech Inc.ProSci Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 22 | 4:00PM - 8:00PM
Arrival and Registration
Room: Van Horne Foyer


Sunday, March 22 | 6:00PM - 8:00PM
Welcome Mixer
Room: Van Horne Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Monday, March 23 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 4
* Patrick C. Wilson, University of Chicago, USA

Monday, March 23 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Van Horne Ballroom A/B

Speaker 2 of 4
* Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois, Switzerland

Monday, March 23 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Van Horne Ballroom A/B

Speaker 3 of 4
Max D. Cooper, Emory University, USA
Comparative Analysis of Alternative Adaptive Immune Systems

Monday, March 23 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Van Horne Ballroom A/B

Speaker 4 of 4
Anthony S. Fauci, NIAID, National Institutes of Health, USA
Toward an HIV Vaccine: A Scientific Journey

Monday, March 23 | 9:30AM - 9:50AM
Coffee Break
Room: Van Horne Foyer


Monday, March 23 | 9:50AM - 11:45AM
Antibody Therapy (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 3
Jeffrey V. Ravetch, Rockefeller University, USA
Fc Effector Functions

Monday, March 23 | 9:50AM - 11:45AM
Antibody Therapy (Joint)
Room: Van Horne Ballroom A/B

Speaker 2 of 3
Gary J. Nabel, Sanofi, USA
The Challenges and Promise of Broadly Neutralizing Abs for HIV Prevention and Treatment

Monday, March 23 | 9:50AM - 11:45AM
Antibody Therapy (Joint)
Room: Van Horne Ballroom A/B

Speaker 3 of 3
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Passive Immunization

Monday, March 23 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Monday, March 23 | 11:15AM - 5:00PM
On Own for Lunch


Monday, March 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: Envelope Structure and Immunogen Design Efforts
Room: Van Horne Ballroom C

Speaker 1 of 9
* Leonidas Stamatatos, Fred Hutchinson Cancer Research Center, USA

Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: Envelope Structure and Immunogen Design Efforts
Room: Van Horne Ballroom C

Speaker 2 of 9
* John P. Moore, Weill Medical College of Cornell University, USA
Production and Properties of Multiple Native-Like SOSIP.664 Trimers

Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: Envelope Structure and Immunogen Design Efforts
Room: Van Horne Ballroom C

Speaker 3 of 9
Gabriel Ozorowski, The Scripps Research Institute, USA
Characterization and Design of HIV-1 Env SOSIP gp140 Trimers

Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: Envelope Structure and Immunogen Design Efforts
Room: Van Horne Ballroom C

Speaker 4 of 9
Jose Maximiliano Medina-Ramírez, University of Amsterdam, Netherlands
A Native-Like HIV-1 Envelope Trimer that Engages Multiple Germline Precursors of Broadly Neutralizing Antibodies

Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: Envelope Structure and Immunogen Design Efforts
Room: Van Horne Ballroom C

Speaker 5 of 9
Guillaume B.E. Stewart-Jones, National Institutes of Health, USA
Crystal Structures of Glycosylated JR-FL and BG505 SOSIP Trimers at 3.7Å Resolution Reveal how N-Linked Glycosylation Shield the Glycan Free CD4 Binding Site

Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: Envelope Structure and Immunogen Design Efforts
Room: Van Horne Ballroom C

Speaker 6 of 9
M. Gordon Joyce, US Military HIV Research Program, USA
Designed HIV-1 Env Molecules from Multiple Clades that Display Structural and Antigenic Characteristics of the Mature Prefusion HIV-1 Env

Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: Envelope Structure and Immunogen Design Efforts
Room: Van Horne Ballroom C

Speaker 7 of 9
Javier Guenaga, IAVI Neutralizing Antibody Center at TSRI, USA
Structure-Guided Identification of gp120 Residues that Increase the Propensity of Env Sequences to Form Native-Like Soluble Trimers

Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: Envelope Structure and Immunogen Design Efforts
Room: Van Horne Ballroom C

Speaker 8 of 9
Richard T. Wyatt, IAVI Neutralizing Antibody Center, The Scripps Research Institute, USA
Identification of New HR1 Proline Substitutions that Stabilize the Cleavage-Independent, Well-Ordered, Native Flexibly Linked (NFL) Trimers

Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: Envelope Structure and Immunogen Design Efforts
Room: Van Horne Ballroom C

Speaker 9 of 9
Wei Cheng, University of Michigan, USA
Optical Trapping Virometry Reveals the Positive Cooperativity of HIV-1 Envelope Glycoproteins in Mediating Viral Infection

Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: B1 Cell Biology
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 1 of 10
* Thomas L. Rothstein, Western Michigan University, USA


Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: B1 Cell Biology
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 2 of 10
* Gregg J. Silverman, New York University Langone Medical Center, USA


Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: B1 Cell Biology
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 3 of 10
Cecilia B. Cavazzoni, Federal University of Rio de Janeiro, Brazil
Characterization of the Repertoire of Natural Antibodies Anti-HSC70


Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: B1 Cell Biology
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 4 of 10
Gudrun F. Debes, Thomas Jefferson University, USA
IL-10 Producing Innate-Like B Cells Are Part of the Skin Immune System and Require
alpha4-beta1 Integrin to Migrate between the Peritoneum and Inflamed Skin


Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: B1 Cell Biology
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 5 of 10
Stephanie Glaesener, Hannover Medical School, Germany
Pneumovax23© Directly Stimulates B Cells in vivo Generating a Predominant IgA Response Early after Vaccination


Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: B1 Cell Biology
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 6 of 10
Benchang Guo, Feinstein Institute for Medical Research, USA
RasGRP1 Shapes Autoreactive Receptor Repertoire in B1a Cells which Prevents Autoimmune Disease


Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: B1 Cell Biology
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 7 of 10
Matthias Hahn, University Medical Center Mainz, Germany
Over-Expression of an Alternative Splice Variant of the Negative NF-kappaB Regulator CYLD Leads to the Development of B-CLL in Mice


Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: B1 Cell Biology
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 8 of 10
Nichol E. Holodick, WMU Medical School, USA
Age-Related Decline in Natural IgM Function: Diversification and Selection of the B-1a Cell Pool with Age


Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: B1 Cell Biology
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 9 of 10
Rudolf Übelhart, National Center for Tumor Diseases, Germany
Structural Differences between IgD and IgM Control B Cell Responsiveness and the Activation of Innate-Like B1 Cells


Monday, March 23 | 2:30PM - 4:30PM
Workshop 1: B1 Cell Biology
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 10 of 10
Andre M. Vale, Universidade Federal do Rio de Janeiro, Brazil
Maintenance of B Cells with Hydrophobic CDR-H3 Intervals within the Peritoneal Cavity


Monday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cell Selection and Tolerance
This session is from B Cells
Room: Theatre

Speaker 1 of 10
* Eric Meffre, Yale University School of Medicine, USA


Monday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cell Selection and Tolerance
This session is from B Cells
Room: Theatre

Speaker 2 of 10
* David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA


Monday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cell Selection and Tolerance
This session is from B Cells
Room: Theatre

Speaker 3 of 10
Lars Nitschke, University of Erlangen, Germany
Siglec-G: A B Cell Inhibitory Receptor Controlling Autoimmunity


Monday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cell Selection and Tolerance
This session is from B Cells
Room: Theatre

Speaker 4 of 10
Martin S. Naradikian, University of Pennsylvania, USA
IL-4 and IL-21 Reciprocally Regulate T-BET Expression in Activated B Cells


Monday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cell Selection and Tolerance
This session is from B Cells
Room: Theatre

Speaker 5 of 10
Jean-Nicolas Schickel, Adimab, LLC, USA
AID Expression in Human B Cell Precursors Is Essential for Central B-Cell Tolerance


Monday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cell Selection and Tolerance
This session is from B Cells
Room: Theatre

Speaker 6 of 10
Masayuki Kuraoka, Duke University, USA
BCR and TLR Synergy Elicits High Levels of AID Expression in Immature/T1 B Cells to Ensure Central B-Cell Tolerance


Monday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cell Selection and Tolerance
This session is from B Cells
Room: Theatre

Speaker 7 of 10
Kristin M.S. Schroeder, National Jewish Health, USA
B Cell Tolerance Mechanisms Limit Protective HIV Antibody Responses


Monday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cell Selection and Tolerance
This session is from B Cells
Room: Theatre

Speaker 8 of 10
Thomas Hägglöf, Karolinska Institutet, Sweden
Neutrophils License NKT Cells to Regulate Self-Reactive B Cell Responses


Monday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cell Selection and Tolerance
This session is from B Cells
Room: Theatre

Speaker 9 of 10
Christopher M. Tipton, Emory University, USA
Diversity, Cellular Origin and Autoreactivity of Antibody-Secreting Cell Expansions in Acute Systemic Lupus Erythematosus


Monday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cell Selection and Tolerance
This session is from B Cells
Room: Theatre

Speaker 10 of 10
Aaron J. Marshall, University of Manitoba, Canada
TAPP Adaptors Control Akt-Dependent Metabolic Activation of B Cells and Suppress Autoimmunity via Binding to the SHIP Product PI(3,4)P2


Monday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Monday, March 23 | 5:00PM - 7:00PM
Natural and Vaccine-Induced Development of Antibody Response
Room: Van Horne Ballroom C

Speaker 1 of 5
* Susan Zolla-Pazner, Icahn School of Medicine at Mount Sinai, USA

Monday, March 23 | 5:00PM - 7:00PM
Natural and Vaccine-Induced Development of Antibody Response
Room: Van Horne Ballroom C

Speaker 2 of 5
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Developmental Pathways of Broadly Neutralizing Antibodies

Monday, March 23 | 5:00PM - 7:00PM
Natural and Vaccine-Induced Development of Antibody Response
Room: Van Horne Ballroom C

Speaker 3 of 5
Pamela J. Bjorkman, California Institute of Technology, USA
Overcoming HIV-1 Evasion of Antibody Avidity with Intra-Spike Crosslinking Reagents

Monday, March 23 | 5:00PM - 7:00PM
Natural and Vaccine-Induced Development of Antibody Response
Room: Van Horne Ballroom C

Speaker 4 of 5
Gunilla B. Karlsson Hedestam, Karolinska Institutet, Sweden
Diversity and Evolution of HIV Env Vaccine-Induced B Cell Responses

Monday, March 23 | 5:00PM - 7:00PM
Natural and Vaccine-Induced Development of Antibody Response
Room: Van Horne Ballroom C

Speaker 5 of 5
Todd C. Bradley, Children's Mercy Kansas City, USA
Short Talk: HIV-1 CD4 Binding Site-Directed Autologous Tier-2 Neutralizing Antibody Lineage Elicited by Immunization with a Swarm of HIV-1 Envs from an African Individual

Monday, March 23 | 5:00PM - 7:15PM
Peripheral B Cell Development and Function
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 1 of 5
* Michael P. Cancro, University of Pennsylvania, USA
New Paths to Peripheral B Cell Tolerance and Differentiation


Monday, March 23 | 5:00PM - 7:15PM
Peripheral B Cell Development and Function
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 2 of 5
Andrea Cerutti, Mount Sinai School of Medicine, USA
Marginal Zone B Cells


Monday, March 23 | 5:00PM - 7:15PM
Peripheral B Cell Development and Function
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 3 of 5
Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Molecular Requirements for Productive Humoral Immunity in Humans - The Power of PIDs


Monday, March 23 | 5:00PM - 7:15PM
Peripheral B Cell Development and Function
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 4 of 5
Michael G. McHeyzer-Williams, The Scripps Research Institute, USA
Molecular Dynamics of Memory B Cell Responses


Monday, March 23 | 5:00PM - 7:15PM
Peripheral B Cell Development and Function
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 5 of 5
Claude-Agnès Reynaud, Necker-Paris Medical School, France
Short Talk: High Throughput Ig Sequencing of Paired Blood and Spleen Samples Allows a Redefinition of IgM Memory Subsets in Humans


Monday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Monday, March 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Mezzanine 2


Tuesday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Tuesday, March 24 | 8:00AM - 11:00AM
B/T Cell Interactions (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 6
* Jason G. Cyster, HHMI/University of California, San Francisco, USA
B Cell Guidance Cues and the Antibody Response

Tuesday, March 24 | 8:00AM - 11:00AM
B/T Cell Interactions (Joint)
Room: Van Horne Ballroom A/B

Speaker 2 of 6
* Shane Crotty, La Jolla Institute for Immunology, USA
T Cell Help to B Cells: Follicular Helper CD4 T Cell (Tfh) Biology

Tuesday, March 24 | 8:00AM - 11:00AM
B/T Cell Interactions (Joint)
Room: Van Horne Ballroom A/B

Speaker 3 of 6
Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois, Switzerland
T Follicular Helper (Tfh) Cells in Health and Chronic HIV Infection

Tuesday, March 24 | 8:00AM - 11:00AM
B/T Cell Interactions (Joint)
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Claudia Cicala, NIAID, National Institutes of Health, USA
Short Talk: Targeting alpha4beta7 Integrin Reduces Mucosal Transmission and Dissemination of SIV

Tuesday, March 24 | 8:00AM - 11:00AM
B/T Cell Interactions (Joint)
Room: Van Horne Ballroom A/B

Speaker 5 of 6
Gabriel D. Victora, Rockefeller University, USA
Short Talk: Clonal Dynamics and Evolution in Germinal Centers

Tuesday, March 24 | 8:00AM - 11:00AM
B/T Cell Interactions (Joint)
Room: Van Horne Ballroom A/B

Speaker 6 of 6
David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA
Short Talk: Distinct Impact of B Cell-Intrinsic Type 1 vs Type 2 Interferon Signals in GC B Cell Tolerance

Tuesday, March 24 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Tuesday, March 24 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, March 24 | 11:00AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Tuesday, March 24 | 11:15AM - 12:45PM
Hands-On Computer Session on Los Alamos Sequence Database
Room: Beatty


Tuesday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 2: New Immunization Tactics
Room: Van Horne Ballroom C

Speaker 1 of 10
* Nicole A. Doria-Rose, NIAID, National Institutes of Health, USA

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 2: New Immunization Tactics
Room: Van Horne Ballroom C

Speaker 2 of 10
* Gunilla B. Karlsson Hedestam, Karolinska Institutet, Sweden

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 2: New Immunization Tactics
Room: Van Horne Ballroom C

Speaker 3 of 10
Rena D. Astronomo, Fred Hutchinson Cancer Research Center, USA
Low Concentrations of Broadly-Neutralizing Antibodies (bnAbs) Protect Against Early Events of Mucosal HIV-1 Infection in a Human ex vivo Vaginal Explant Model

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 2: New Immunization Tactics
Room: Van Horne Ballroom C

Speaker 4 of 10
Jinghe Huang, NIAID, National Institutes of Health, USA
Isolation of a Broad and Potent CD4-Binding Site Monoclonal Antibody with Novel Binding Characteristics

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 2: New Immunization Tactics
Room: Van Horne Ballroom C

Speaker 5 of 10
Joseph G. Jardine, The Scripps Research Institute, USA
In vivo Activation of GL-VRC01 Class Antibodies in Transgenic Mice by Germline-Targeted Immunizations

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 2: New Immunization Tactics
Room: Van Horne Ballroom C

Speaker 6 of 10
Huaxin Liao, Duke University Medical Center, USA
HIV-1 CH505 Env Immunogens Initiated CD4 Binding Site Antibody Lineage in Rhesus macaques

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 2: New Immunization Tactics
Room: Van Horne Ballroom C

Speaker 7 of 10
Aaron Louie, National Institutes of Health, USA
HIV-Specific Antibodies Derived from Exhausted Memory B Cells of Infected Individuals Show Deficiencies in Neutralization and Somatic Hypermutation

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 2: New Immunization Tactics
Room: Van Horne Ballroom C

Speaker 8 of 10
Delphine C. Malherbe, Oregon Health & Science University, USA
Early Breadth Clade C Env Immunogens Elicit Cross-Clade NAbs and Env-Specific Tfh Responses

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 2: New Immunization Tactics
Room: Van Horne Ballroom C

Speaker 9 of 10
Jose M. Martinez-Navio, University of Miami - LSTP, USA
Host Anti-Antibody Responses following AAV-Mediated Delivery of Antibodies Against HIV and SIV

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 2: New Immunization Tactics
Room: Van Horne Ballroom C

Speaker 10 of 10
Rogier W. Sanders, University of Amsterdam and Weill Cornell Medical College, Netherlands
HIV Neutralizing Antibodies Induced by Native-Like Envelope Trimers

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Vaccines and Immunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 1 of 9
* Bonnie B. Blomberg, University of Miami School of Medicine, USA


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Vaccines and Immunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 2 of 9
Paul V. Thomas, NIAID, National Institutes of Health, USA
Structural Definition of a Novel Set of Converged Broadly Neutralizing Influenza Antibodies Elicited in H5N1 Vaccinees


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Vaccines and Immunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 3 of 9
Goetz R. Ehrhardt, University of Toronto, Canada
Biomarker Discovery on Memory B Cells and Plasma Cells Using Monoclonal VLR Antibodies


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Vaccines and Immunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 4 of 9
Carole Henry, University of Chicago, USA
Pre-Existing Human Antibodies Neutralize the Novel Influenza H7N9 Strain


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Vaccines and Immunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 5 of 9
Mattias Forsell, Umeå University, Sweden
Activation of Circulating Platelets Leads to the Release of Potent Antiviral IgG


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Vaccines and Immunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 6 of 9
Hana Golding, US Food and Drug Administration, USA
Exploring Antibody Repertoires and Affinity Maturation Against Pandemic Influenza Vaccines: Impact of Adjuvants and Prime-Boost Approaches


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Vaccines and Immunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 7 of 9
Gregory C. Ippolito, University of Texas at Austin, USA
New Molecular and Proteomic Techniques for the 'Deep' Profiling of Vaccine-Elicited Cellular and Serological Antibody Repertoires


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Vaccines and Immunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 8 of 9
Greg A. Kirchenbaum, Vaccine and Gene Therapy Institute of Florida, USA
Longitudinal Profiling of Young and Elderly Individuals in Response to Seasonal Influenza Vaccination


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Vaccines and Immunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 9 of 9
Ignacio Sanz, Emory University, School of Medicine, USA
Identification of Long-lived Plasma Cells in Human Bone Marrow


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 4: B Cell Development and Signaling
This session is from B Cells
Room: Theatre

Speaker 1 of 8
Julia Jellusova, University of Freiburg, Germany
GSK3 Regulates B Cell Metabolism, Cell Growth and Proliferation


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 4: B Cell Development and Signaling
This session is from B Cells
Room: Theatre

Speaker 2 of 8
Nikita S. Kolhatkar, University of Washington, USA
The Role of Altered Antigen Receptor Signaling in Wiskott Aldrich Syndrome


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 4: B Cell Development and Signaling
This session is from B Cells
Room: Theatre

Speaker 3 of 8
Ai Kotani, Tokai University, Japan
A Single miRNA Substitutes for Requirement of EBF1 in B Lineage Commitment


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 4: B Cell Development and Signaling
This session is from B Cells
Room: Theatre

Speaker 4 of 8
Jinmin Lee, NIAID, National Institutes of Health, USA
Defining the Oligomeric State on B Cell Receptors on the Surfaces of Human Naïve and Memory B Cells Using Super-Resolution Fluorescence Microscopy


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 4: B Cell Development and Signaling
This session is from B Cells
Room: Theatre

Speaker 5 of 8
Stephen K. H. Li, Western University, Canada
Identification of a Negative Regulatory Role for the E26 Transformation-Specific Transcription Factor Spi-C in the Murine B Cell Lineage


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 4: B Cell Development and Signaling
This session is from B Cells
Room: Theatre

Speaker 6 of 8
Hongsheng Wang, NIAID, National Institutes of Health, USA
An Essential Role of Transcription Factors PU.1 and IRF8 in Follicular B Cell Development and the Germinal Center Response


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 4: B Cell Development and Signaling
This session is from B Cells
Room: Theatre

Speaker 7 of 8
* Duane R. Wesemann, Harvard Medical School, USA
Role of Environment in the Shaping of the Primary Immunoglobulin Repertoire


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 4: B Cell Development and Signaling
This session is from B Cells
Room: Theatre

Speaker 8 of 8
Maryaline Coffre, New York University School of Medicine, USA
Dicer-Dependent Non-Coding RNAs Are Essential for B Cell Development and Maturation


Tuesday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, March 24 | 5:00PM - 7:00PM
Predictors of Response to Vaccines
Room: Van Horne Ballroom C

Speaker 1 of 3
* Dennis R. Burton, The Scripps Research Institute, USA

Tuesday, March 24 | 5:00PM - 7:00PM
Predictors of Response to Vaccines
Room: Van Horne Ballroom C

Speaker 2 of 3
Rafick Sekaly, Case Western Reserve University, USA
Genetic and Epigenetic Determinants of Vaccine Responses

Tuesday, March 24 | 5:00PM - 7:00PM
Predictors of Response to Vaccines
Room: Van Horne Ballroom C

Speaker 3 of 3
Tobias R. Kollmann, Telethon Kids Institute, Australia
Predictors of Vaccine Responses in Children

Tuesday, March 24 | 5:00PM - 7:15PM
Memory and Plasma Cell Differentiation and Fate
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 1 of 5
* Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Germany


Tuesday, March 24 | 5:00PM - 7:15PM
Memory and Plasma Cell Differentiation and Fate
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 2 of 5
Patrick C. Wilson, University of Chicago, USA
Immune Memory Shapes B Cell Responses to Influenza


Tuesday, March 24 | 5:00PM - 7:15PM
Memory and Plasma Cell Differentiation and Fate
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 3 of 5
David M. Allman, University of Pennsylvania, USA
Plasma Cell Subpopulations in the Bone Marrow


Tuesday, March 24 | 5:00PM - 7:15PM
Memory and Plasma Cell Differentiation and Fate
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 4 of 5
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Signaling and Selection in GC B Cells


Tuesday, March 24 | 5:00PM - 7:15PM
Memory and Plasma Cell Differentiation and Fate
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 5 of 5
Kim Good-Jacobson, Monash University, Australia
Short Talk: c-Myb Establishes a Transcriptional Network in Germinal Center B Cells that Controls T-bet, Class Selection and Long-Term Immunity


Tuesday, March 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Tuesday, March 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Mezzanine 2


Wednesday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Wednesday, March 25 | 8:00AM - 11:15AM
Anti-Viral B Cell Responses (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 6
Barton F. Haynes, Duke University Medical Center, USA
Ontogenicity of Broadly Neutralizing Antibodies during HIV-1 Infection

Wednesday, March 25 | 8:00AM - 11:15AM
Anti-Viral B Cell Responses (Joint)
Room: Van Horne Ballroom A/B

Speaker 2 of 6
John R. Mascola, NIAID, National Institutes of Health, USA
Antibody Responses to HIV

Wednesday, March 25 | 8:00AM - 11:15AM
Anti-Viral B Cell Responses (Joint)
Room: Van Horne Ballroom A/B

Speaker 3 of 6
* Leonidas Stamatatos, Fred Hutchinson Cancer Research Center, USA
Characterization of Recombinant HIV-1 Envelopes that Bind Germline Forms of Broadly Neutralizing Antibodies

Wednesday, March 25 | 8:00AM - 11:15AM
Anti-Viral B Cell Responses (Joint)
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Ian A. Wilson, The Scripps Research Institute, USA
Broad Neutralization of Influenza Viruses

Wednesday, March 25 | 8:00AM - 11:15AM
Anti-Viral B Cell Responses (Joint)
Room: Van Horne Ballroom A/B

Speaker 5 of 6
Pia Dosenovic, Karolinska Institutet, Sweden
Short Talk: Development of HIV-1 Broadly Neutralizing Antibodies in Human Variable Region Knock-In Mice

Wednesday, March 25 | 8:00AM - 11:15AM
Anti-Viral B Cell Responses (Joint)
Room: Van Horne Ballroom A/B

Speaker 6 of 6
Scott D. Boyd, Stanford University, USA
Short Talk: Storage and Recall of Anti-Influenza Antibodies in Younger and Older Adults

Wednesday, March 25 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Wednesday, March 25 | 11:15AM - 12:45PM
Hands-on Computer Session on Los Alamos Immunology Database
Room: Beatty


Wednesday, March 25 | 11:15AM - 12:15PM
Meet the Editors
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 1 of 7
* Catarina Sacristán, Cell Press, USA


Wednesday, March 25 | 11:15AM - 12:15PM
Meet the Editors
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 2 of 7
Alison Farrell, Springer Nature, USA


Wednesday, March 25 | 11:15AM - 12:15PM
Meet the Editors
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 3 of 7
Fabiola V. Rivas, Cell Press, USA


Wednesday, March 25 | 11:15AM - 12:15PM
Meet the Editors
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 4 of 7
Liz Thompson, Immunity, Cell Press, USA


Wednesday, March 25 | 11:15AM - 12:15PM
Meet the Editors
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 5 of 7
Sri Devi Narasimhan, Cell Press, USA


Wednesday, March 25 | 11:15AM - 12:15PM
Meet the Editors
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 6 of 7
Gabriel A. Gasque, PLOS Biology, USA


Wednesday, March 25 | 11:15AM - 12:15PM
Meet the Editors
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 7 of 7
Kristen L. Mueller, Science Magazine, USA


Wednesday, March 25 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Wednesday, March 25 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 3: B Cell Pathogenesis and BCR Repertoire Session
Room: Van Horne Ballroom C

Speaker 1 of 8
* Susan Moir, NIAID, National Institutes of Health, USA

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 3: B Cell Pathogenesis and BCR Repertoire Session
Room: Van Horne Ballroom C

Speaker 2 of 8
* Matthieu Perreau, University Hospital of Lausanne, Switzerland

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 3: B Cell Pathogenesis and BCR Repertoire Session
Room: Van Horne Ballroom C

Speaker 3 of 8
James J. Knox, University of Pennsylvania, USA
HIV Infection Induces the Expansion of T-Bet Expressing B Lymphocytes

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 3: B Cell Pathogenesis and BCR Repertoire Session
Room: Van Horne Ballroom C

Speaker 4 of 8
Thomas Liechti, Institute of Medical Virology, Switzerland
Tracing B Cell Subset Changes during Acute and Chronic HIV-1 Infection and Restoration upon ART Initiation

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 3: B Cell Pathogenesis and BCR Repertoire Session
Room: Van Horne Ballroom C

Speaker 5 of 8
Chung Park, NIAID, National Institutes of Health, USA
Lymph Node B Cells Survey Interfollicular SIGN-R1+ Macrophages that Capture HIV-1 gp120

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 3: B Cell Pathogenesis and BCR Repertoire Session
Room: Van Horne Ballroom C

Speaker 6 of 8
D. Noah Sather, Center for Infectious Disease Research, USA
Repertoire Analysis of the B Cell Receptor-Encoding Loci in Humans and Rhesus macaques by Next Generation Sequencing

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 3: B Cell Pathogenesis and BCR Repertoire Session
Room: Van Horne Ballroom C

Speaker 7 of 8
Chaim A. Schramm, NIAID, National Institutes of Health, USA
Longitudinal Deep-Sequencing of the VRC01-Antibody Lineage Reveals High Evolutionary Rate and Extraordinary Diversity

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 3: B Cell Pathogenesis and BCR Repertoire Session
Room: Van Horne Ballroom C

Speaker 8 of 8
Zizhang Sheng, Columbia University, USA
Evolutionary Rate Dynamics of HIV-1 Broadly Neutralizing Antibody Lineages

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 5: Affinity Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 1 of 10
* Kim Good-Jacobson, Monash University, Australia


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 5: Affinity Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 2 of 10
* Garnett H. Kelsoe, Duke University and Medical Center, USA


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 5: Affinity Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 3 of 10
Alexander D. Gitlin, Rockefeller University, USA
Clonal Selection in the Germinal Center by Regulated Proliferation and Hypermutation


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 5: Affinity Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 4 of 10
Stephen P. Methot, Institut de Recherches Cliniques de Montreal, Canada
Consecutive Interactions with HSP90 and eEF1A1 Underlie a Functional Maturation and Storage Pathway of AID in the Cytoplasm


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 5: Affinity Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 5 of 10
Heping Xu, Cincinnati Children's Hospital Medical Center, USA
Regulation of Bifurcating B Cell Responses by IRF4 and IRF8-Mediated Reciprocal Feedback


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 5: Affinity Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 6 of 10
Zhiyong Yang, University of California, San Francisco, USA
Plasma Cell Differentiation Driven by Antigen-Independent Signaling Activity of the IgE B Cell Receptor


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 5: Affinity Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 7 of 10
Rushad Pavri, Institute for Molecular Pathology, Austria
The Role of the Mcm Complex in Class Switch Recombination


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 5: Affinity Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 8 of 10
Jennifer L. Yates, New York State Department of Health, USA
Innate iNKT Cells Provide T-Dependent Type 2 Help for B Cells: Expanding the Helper Paradigm


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 5: Affinity Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 9 of 10
Jing H. Wang, University of Colorado Anschutz Medical Campus, USA
The Imbalanced Signaling between PTEN and Phosphoinositide 3-Kinase Impairs Class Switch Recombination


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 5: Affinity Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 10 of 10
Nobuo Sakaguchi, Kumamoto University, Japan
Regulation of Selective Non-Coding RNA Species Involved in B-Cell Maturation by AID-Interacting Molecule GANP


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 4: Ab Based Therapy for Prevention and for Cure
Room: Theatre

Speaker 1 of 10
* Richard A. Koup, NIAID, National Institutes of Health, USA

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 4: Ab Based Therapy for Prevention and for Cure
Room: Theatre

Speaker 2 of 10
* M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 4: Ab Based Therapy for Prevention and for Cure
Room: Theatre

Speaker 3 of 10
Sara Ferrando-Martinez, NIAID, National Institutes of Health, USA
Follicular CD8 T Cells Have Superior Cytolytic Capacity and Mediate a Redirected Killing of HIV-Infected Cells by Bispecific Antibodies

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 4: Ab Based Therapy for Prevention and for Cure
Room: Theatre

Speaker 4 of 10
M. Anthony Moody, Duke University Medical Center, USA
Elevated Prevalence of Autoantibodies in HIV-Infected Individuals with Plasma Broadly Reactive Neutralizing Antibodies (bnAbs) Compared to Infected Individuals Lacking Plasma bnAbs

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 4: Ab Based Therapy for Prevention and for Cure
Room: Theatre

Speaker 5 of 10
Ariel Halper-Stromberg, Rockefeller University, USA
Targeting the HIV-1 Reservoir in Humanized Mice Using Broadly Neutralizing Antibodies and Viral Inducers

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 4: Ab Based Therapy for Prevention and for Cure
Room: Theatre

Speaker 6 of 10
Ann J. Hessell, Oregon Health & Science University, USA
Post-Exposure Treatment with Neutralizing mAbs Ablates SHIV Infection in Infant Rhesus macaques and Limits Establishment of Latent Viral Reservoirs

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 4: Ab Based Therapy for Prevention and for Cure
Room: Theatre

Speaker 7 of 10
Smita S. Iyer, Emory University, USA
Co-Delivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CD4+ T Follicular Helper Cell Response in Rhesus macaques

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 4: Ab Based Therapy for Prevention and for Cure
Room: Theatre

Speaker 8 of 10
Amarendra Pegu, NIAID, National Institutes of Health, USA
Efficacy of Antibody Therapy in Acute SHIV-Infected Macaques

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 4: Ab Based Therapy for Prevention and for Cure
Room: Theatre

Speaker 9 of 10
Akshaya Ramesh, Boston University School of Medicine, USA
Macaque Immunogenetics through de-novo Genome Assemblies

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 4: Ab Based Therapy for Prevention and for Cure
Room: Theatre

Speaker 10 of 10
Veronika Schmid, University of Regensburg, Germany
Characterization of Anti-HIV-1 Envelope Antibodies Using a FACS Based High Throughput Mapping Platform

Wednesday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, March 25 | 5:00PM - 7:00PM
Envelope Structure
Room: Van Horne Ballroom C

Speaker 1 of 5
* Peter D. Kwong, NIAID, National Institutes of Health, USA

Wednesday, March 25 | 5:00PM - 7:00PM
Envelope Structure
Room: Van Horne Ballroom C

Speaker 2 of 5
Sriram Subramaniam, University of British Columbia, Canada
Structural Mechanism of HIV Entry

Wednesday, March 25 | 5:00PM - 7:00PM
Envelope Structure
Room: Van Horne Ballroom C

Speaker 3 of 5
Dennis R. Burton, The Scripps Research Institute, USA
Envelope-Glycosylation and Antibody-Recognition

Wednesday, March 25 | 5:00PM - 7:00PM
Envelope Structure
Room: Van Horne Ballroom C

Speaker 4 of 5
Walther Mothes, Yale University School of Medicine, USA
Conformational Dynamics of Single HIV-1 Envelope Trimers on Native Virions

Wednesday, March 25 | 5:00PM - 7:00PM
Envelope Structure
Room: Van Horne Ballroom C

Speaker 5 of 5
Andrew B. Ward, The Scripps Research Institute, USA
Short Talk: High-Resolution Cryo-EM Studies of HIV-1 Envelope

Wednesday, March 25 | 5:00PM - 7:30PM
Antibody Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 1 of 6
* Tasuku Honjo, Kyoto University Graduate School of Medicine, Japan
Molecular Mechanism of AID-Mediated SHM and SCR


Wednesday, March 25 | 5:00PM - 7:30PM
Antibody Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 2 of 6
Frederick W. Alt, Boston Children's Hospital, USA
Mechanisms that Direct Specificity and Outcome of Activation-Induced Cytidine Deaminase (AID) Activity


Wednesday, March 25 | 5:00PM - 7:30PM
Antibody Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 3 of 6
Rafael Casellas, NIAMS-NCI, National Institutes of Health, USA
AID Targeting


Wednesday, March 25 | 5:00PM - 7:30PM
Antibody Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Patricia J. Gearhart, NIA, National Institutes of Health, USA
Short Talk: DNA Polymerases Iota and Zeta Standoff during Antibody Hypermutation


Wednesday, March 25 | 5:00PM - 7:30PM
Antibody Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 5 of 6
Uttiya Basu, USA
Short Talk: In B Cells, High-Throughput Proteomic Screen Identifies Co-Factors for RNA Exosome that Facilitates AID Access to Both Strands of Transcribed DNA


Wednesday, March 25 | 5:00PM - 7:30PM
Antibody Maturation and Class Switch
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 6 of 6
Kevin M. McBride, University of Texas MD Anderson Cancer Center, USA
Short Talk: Uracil DNA Glycosylase of Gammaherpesvirus Alters B Cell Class Switch Recombination


Wednesday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Wednesday, March 25 | 7:30PM - 10:00PM
Poster Session 3
Room: Mezzanine 2


Thursday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Thursday, March 26 | 8:00AM - 11:00AM
HIV Vaccine Clinical Development
Room: Van Horne Ballroom C

Speaker 1 of 6
* Peggy Johnston, Bill & Melinda Gates Foundation, USA

Thursday, March 26 | 8:00AM - 11:00AM
HIV Vaccine Clinical Development
Room: Van Horne Ballroom C

Speaker 2 of 6
* M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA
Overview of HIV Clinical Vaccine Development

Thursday, March 26 | 8:00AM - 11:00AM
HIV Vaccine Clinical Development
Room: Van Horne Ballroom C

Speaker 3 of 6
Nelson L. Michael, Walter Reed Army Institute of Research, USA
Immune Correlates of Protection

Thursday, March 26 | 8:00AM - 11:00AM
HIV Vaccine Clinical Development
Room: Van Horne Ballroom C

Speaker 4 of 6
Nathalie Garçon, Bioaster, France
Challenges in the Preclinical and Clinical Development of Novel Adjuvants

Thursday, March 26 | 8:00AM - 11:00AM
HIV Vaccine Clinical Development
Room: Van Horne Ballroom C

Speaker 5 of 6
Kristin L. Boswell, NIAID, National Institutes of Health, USA
Short Talk: Characterization of CD150 Expression and Function on SHIV-Specific TFH Cells

Thursday, March 26 | 8:00AM - 11:00AM
HIV Vaccine Clinical Development
Room: Van Horne Ballroom C

Speaker 6 of 6
Rebecca M. Lynch, George Washington University, USA
Short Talk: Virologic Impact of VRC01-Infusion in HIV-1 Infected Subjects

Thursday, March 26 | 8:00AM - 11:30AM
B Cell Immune Deficiencies
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 1 of 7
* Anne Durandy, Institut Imagine, France
Immunoglobulin Class Switch Recombination Deficiencies: An Update


Thursday, March 26 | 8:00AM - 11:30AM
B Cell Immune Deficiencies
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 2 of 7
Klaus Warnatz, University Clinic Freiburg, Germany
NF-kappaB in B Cell Differentiation - From an Immunodeficient Standpoint


Thursday, March 26 | 8:00AM - 11:30AM
B Cell Immune Deficiencies
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 3 of 7
Mary Ellen Conley, Rockefeller University, USA
Defects in Early B Cell Development


Thursday, March 26 | 8:00AM - 11:30AM
B Cell Immune Deficiencies
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 4 of 7
Lennart Hammarström, Karolinska Institute, Sweden
Defects in Late B Cell Development - Lessons from WES and WGS


Thursday, March 26 | 8:00AM - 11:30AM
B Cell Immune Deficiencies
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 5 of 7
Jacob M. Rosenberg, Harvard University, USA
Short Talk: The Landscape and Function of Anti-Cytokine Autoantibodies in Health and Primary Immunodeficiency


Thursday, March 26 | 8:00AM - 11:30AM
B Cell Immune Deficiencies
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 6 of 7
Fabienne Mackay, Monash University, Australia
Short Talk: The TACI Receptor Regulates T-Independent Marginal Zone B Cell Responses through Innate Activation-Induced Cell Death


Thursday, March 26 | 8:00AM - 11:30AM
B Cell Immune Deficiencies
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 7 of 7
Jayanta Chaudhuri, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Non-Coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA


Thursday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Thursday, March 26 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 5: B/T Cell Interactions
Room: Van Horne Ballroom C

Speaker 1 of 8
* Rama Rao Amara, Emory University, USA

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 5: B/T Cell Interactions
Room: Van Horne Ballroom C

Speaker 2 of 8
Robert Abbott, La Jolla Institute for Allergy and Immunology, USA
The A2a Adenosine Receptor Is Required for Affinity Maturation in the Germinal Center

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 5: B/T Cell Interactions
Room: Van Horne Ballroom C

Speaker 3 of 8
Atef F. Allam, Walter Reed Institute of Research, USA
TFH Cells Accumulate in the Female Reproductive Tract and in Peyer’s Patches of Humanized DRAG Mice, Are Highly Permissive to HIV-1, and Show Impaired Cytokine Production Over the Course of HIV-1 Infection

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 5: B/T Cell Interactions
Room: Van Horne Ballroom C

Speaker 4 of 8
John P. Barton, University of California, Riverside, USA
Computational Prediction of Intra-Individual HIV Evolution to Evade Cellular Immune Selection Pressure

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 5: B/T Cell Interactions
Room: Van Horne Ballroom C

Speaker 5 of 8
Thorsten Demberg, NCI, National Institutes of Health, USA
Persistent Loss and Dysregulation of Marginal Zone B-Cells after SHIVSF162P4 Challenge Despite Control of Viremia

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 5: B/T Cell Interactions
Room: Van Horne Ballroom C

Speaker 6 of 8
Colin Havenar-Daughton, Vir Biotechnology, USA
T Follicular Helper Cell and Germinal Center B Cell Responses to HIV gp140 Protein + TLR-Encapsulated Nanoparticle Immunization in Rhesus macaques

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 5: B/T Cell Interactions
Room: Van Horne Ballroom C

Speaker 7 of 8
Joyce K. Hu, La Jolla Institute of Allergy and Immunology, USA
Characterization of Antibody and Tfh Cell Responses after BG505 SOSIP.664 Trimer Immunizations in Mice

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 5: B/T Cell Interactions
Room: Van Horne Ballroom C

Speaker 8 of 8
Yin Xu, University of New South Wales, Australia
HIV Entry into T Follicular Helper (Tfh) Cells May Be Associated with CCR5+ Pre-Tfh Cells in Lymph Nodes

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 6: System Immunology and Modeling
This session is from B Cells
Room: Theatre

Speaker 1 of 10
* Sarah Cobey, University of Chicago, USA


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 6: System Immunology and Modeling
This session is from B Cells
Room: Theatre

Speaker 2 of 10
* Uri Hershberg, Drexel University, USA


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 6: System Immunology and Modeling
This session is from B Cells
Room: Theatre

Speaker 3 of 10
Brandon DeKosky, University of Kansas, USA
Paired VH:VL Analysis of Naïve B-Cell Repertoires and Comparison to Antigen-Experienced B-Cell Repertoires in Healthy Human Donors


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 6: System Immunology and Modeling
This session is from B Cells
Room: Theatre

Speaker 4 of 10
Thomas B. Kepler, Boston University, USA
B Cell Clonal Dynamics during Sequential Immunizations


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 6: System Immunology and Modeling
This session is from B Cells
Room: Theatre

Speaker 5 of 10
Frederick A. Matsen IV, Fred Hutchinson Cancer Research Center, USA
Quantifying Evolutionary Constraints on B Cell Affinity Maturation


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 6: System Immunology and Modeling
This session is from B Cells
Room: Theatre

Speaker 6 of 10
Lauren M. Childs, Virginia Tech, USA
Affinity Maturation of B Cells in the Presence of Competing Antigens


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 6: System Immunology and Modeling
This session is from B Cells
Room: Theatre

Speaker 7 of 10
Jason Anthony Vander Heiden, Genetech, Inc., USA
High-Throughput Immunoglobulin Sequencing Informatics: Insights into B Cell Trafficking Patterns in Multiple Sclerosis


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 6: System Immunology and Modeling
This session is from B Cells
Room: Theatre

Speaker 8 of 10
Gregory W. Schwartz, University of Pennsylvania, USA
Conserved Amino Acid Diversity in B Cell Repertoires Connects between Selection at the Germline and Somatic Levels


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 6: System Immunology and Modeling
This session is from B Cells
Room: Theatre

Speaker 9 of 10
Tom MacCarthy, Stony Brook University, USA
The Number of Overlapping AID Hotspots within Germline Immunoglobulin Heavy Chain V-Regions Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 6: System Immunology and Modeling
This session is from B Cells
Room: Theatre

Speaker 10 of 10
Rajagopal Murugan, German Cancer Research Institute, Germany
High Throughput Analysis of B Cell Clonal Expansion and Antibody Selection to Controlled Plasmodium falciparum Infection


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 7: B Cell Related Diseases
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 1 of 9
* Ignacio Sanz, Emory University, School of Medicine, USA


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 7: B Cell Related Diseases
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 2 of 9
* Fabienne Mackay, Monash University, Australia


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 7: B Cell Related Diseases
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 3 of 9
John H. Kehrl, NIAID, National Institutes of Health, USA
B Lymphocyte Specific Loss of Ric-8A Causes a Galpha Protein Deficit and Severe Humoral Immunodeficiency


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 7: B Cell Related Diseases
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 4 of 9
Cindy Eunhee Lee, Australian National University, Australia
Autosomal Dominant B Cell Deficiency with Alopecia Due to a Mutation in NF-kappaB2 that Results in Unprocessable p100


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 7: B Cell Related Diseases
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 5 of 9
Nadine Hövelmeyer, University of Mainz, Germany
The Transcription Factor Bcl-3 Regulates the Development of Marginal Zone, Germinal Center and B1 B Cells


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 7: B Cell Related Diseases
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 6 of 9
Wanli Liu, Tsinghua University, China
Membrane Sequestration of the mIgG Cytoplasmic Tail Confers a Safety Trigger Mechanism for the Enhanced Activation of IgG-Memory B Cell


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 7: B Cell Related Diseases
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 7 of 9
Jürgen Wienands, Georg August University of Goettingen, Germany
Absence of CIN85 Expression Presents with X-Chromosome-Linked Antibody Deficiency in Humans


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 7: B Cell Related Diseases
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 8 of 9
Lynnea Rae Waters, University of California, Los Angeles, USA
T Follicular Helper Cell Differentiation Is Blocked by Lkb1 Inhibition of NF-kappaB in B Cells


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 7: B Cell Related Diseases
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 9 of 9
Wei Cao, UT MD Anderson Cancer Center, USA
Humoral Autoimmunity Is Promoted by Type I Interferon-Induced Interferon gamma but Restricted by ROS-Producing Neutrophils


Thursday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, March 26 | 5:00PM - 7:00PM
HIV Functional Cure and/or Eradication
Room: Van Horne Ballroom C

Speaker 1 of 4
* Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois, Switzerland

Thursday, March 26 | 5:00PM - 7:00PM
HIV Functional Cure and/or Eradication
Room: Van Horne Ballroom C

Speaker 2 of 4
Persephone Borrow, University of Oxford, UK
Relationship between CD4+ T Cell Subsets and the Neutralization Breadth of the Antibody Response Generated during HIV-1 Infection

Thursday, March 26 | 5:00PM - 7:00PM
HIV Functional Cure and/or Eradication
Room: Van Horne Ballroom C

Speaker 3 of 4
Matthieu Perreau, University Hospital of Lausanne, Switzerland
Combined Immunological/Virological Therapies for HIV Functional Cure/Eradication

Thursday, March 26 | 5:00PM - 7:00PM
HIV Functional Cure and/or Eradication
Room: Van Horne Ballroom C

Speaker 4 of 4
Michael Farzan, The Scripps Research Institute, USA
AAV-Expressed eCD4-Ig Provides Durable Protection from Multiple SHIV Challenges

Thursday, March 26 | 5:00PM - 7:00PM
B Cell Autoimmunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 1 of 5
* Martin G. Weigert, University of Chicago, USA


Thursday, March 26 | 5:00PM - 7:00PM
B Cell Autoimmunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 2 of 5
Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Endosomal and Cytosolic Nucleic Acid Sensors in Autoimmunity


Thursday, March 26 | 5:00PM - 7:00PM
B Cell Autoimmunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 3 of 5
Hedda Wardemann, German Cancer Research Center, Germany
Single Cell-Based High-Throughput Analysis of Human B Cell Antibody Responses


Thursday, March 26 | 5:00PM - 7:00PM
B Cell Autoimmunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 4 of 5
Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Follicular Dendritic Cells Are Essential for Maintenance of Autoreactive B Cells


Thursday, March 26 | 5:00PM - 7:00PM
B Cell Autoimmunity
This session is from B Cells
Room: Van Horne Ballroom A/B

Speaker 5 of 5
Haochu Huang, Genentech, Inc., USA
Short Talk: Spontaneous B Cell Class Switching in the Thymus and Tolerance


Thursday, March 26 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Van Horne Ballroom C


Thursday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Thursday, March 26 | 8:00PM - 11:00PM
Entertainment
Room: Mezzanine 2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 26 | 8:00PM - 11:00PM
Cash Bar
Room: Mezzanine 2


Friday, March 27 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.