Web Desc
Obesity and the Metabolic Syndrome: Mitochondria and Energy Expenditure
joint with Liver Metabolism and Nonalcoholic Fatty Liver Disease (NAFLD)
Organizer(s): Johan Auwerx, Eleftheria Maratos-Flier and Thomas Langer
Date: March 22 - 27, 2015
Location: Fairmont Chateau Whistler, Whistler, BC, Canada
Sponsored by Nestlé Institute of Health Sciences and Novo Nordisk A/S
Summary of Meeting:
A medical challenge of the 21st century is the coupling of an unprecedented increase in life expectancy with a large increase in incidence and prevalence of chronic multifactorial diseases. Classic disease examples include disorders of metabolism such as obesity and type 2 diabetes mellitus, which are often associated with co-morbidities including non-alcoholic liver disease and coronary, peripheral and central vascular disease. Collectively, the spectrum of disorders is often referred to as the metabolic syndrome. Over the past decade, it has become evident that shifts in cellular metabolism are often linked to changes in the number, morphology and function of mitochondria, and that these cellular changes underlie systemic metabolic abnormalities that characterize the many clinical features of the metabolic syndrome. This meeting will discuss novel findings that link mitochondrial function in peripheral tissues, such as liver, muscle and gut, with the systemic abnormalities of the metabolic syndrome. The potential for identifying new therapeutics that are based on modifying mitochondrial function will be reviewed. As mitochondrial function is now acknowledged to also control metabolic homeostasis on an organismal level in addition to controlling energy homeostasis at the cellular level, this meeting will create a truly interdisciplinary environment that brings together basic scientists in the fields of bioenergetics, physiology, and mitochondrial and cell biology, and clinicians with an interest in metabolic disease, to foster innovative ideas in this area.
Scholarship Deadline: November 20 2014
Discounted Abstract Deadline: November 20 2014
Abstract Deadline: December 18 2014
Discounted Registration Deadline: January 21 2015
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Nestlé Institute of Health SciencesNovo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
Adipogen InternationalALPCO DiagnosticsCell Signaling Technology, Inc.Seahorse Bioscience, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK104611-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 22 | 4:00PM - 8:00PM
Arrival and Registration
Room: Macdonald Foyer


Sunday, March 22 | 6:00PM - 8:00PM
Welcome Mixer
Room: Macdonald Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac ABC


Monday, March 23 | 8:00AM - 9:00AM
Keynote Address
Room: Macdonald DEF

Speaker 1 of 2
* Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland

Monday, March 23 | 8:00AM - 9:00AM
Keynote Address
Room: Macdonald DEF

Speaker 2 of 2
Jodi Nunnari, University of California, Davis, USA
Molecular Mechanisms of Mitochondrial Behavior

Monday, March 23 | 9:00AM - 11:15AM
Mitochondrial Function and Morphology and the Metabolic Synd
rome

Room: Macdonald DEF

Speaker 1 of 4
* Andrew G. Dillin, University of California, Berkeley, USA

Monday, March 23 | 9:00AM - 11:15AM
Mitochondrial Function and Morphology and the Metabolic Synd
rome

Room: Macdonald DEF

Speaker 2 of 4
Orian S. Shirihai, University of California, Los Angeles, USA
Mitochondrial Fission/Fusion and Pancreatic Function

Monday, March 23 | 9:00AM - 11:15AM
Mitochondrial Function and Morphology and the Metabolic Synd
rome

Room: Macdonald DEF

Speaker 3 of 4
David C. Chan, California Institute of Technology, USA
Regulation of Mitochondrial Fusion

Monday, March 23 | 9:00AM - 11:15AM
Mitochondrial Function and Morphology and the Metabolic Synd
rome

Room: Macdonald DEF

Speaker 4 of 4
Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
Mitonuclear Protein Balance as a Determinant of Health- and Lifespan

Monday, March 23 | 9:00AM - 11:15AM
Hepatic Flux in NAFLD
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 1 of 4
* Jay D. Horton, University of Texas Southwestern Medical Center, USA


Monday, March 23 | 9:00AM - 11:15AM
Hepatic Flux in NAFLD
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 2 of 4
Shawn C. Burgess, University of Texas Southwestern Medical Center, USA
Obesity’s Beast of Burden


Monday, March 23 | 9:00AM - 11:15AM
Hepatic Flux in NAFLD
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 3 of 4
Brian N. Finck, Washington University School of Medicine, USA
New Pathways for Targeting Metabolic Disease and Hepatic Steatosis


Monday, March 23 | 9:00AM - 11:15AM
Hepatic Flux in NAFLD
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 4 of 4
Eric B. Taylor, University of Iowa, USA
Regulation of Hepatic Gluconeogenesis by Mitochondrial Pyruvate Carrier 1


Monday, March 23 | 9:40AM - 10:00AM
Coffee Break
Room: Macdonald Foyer


Monday, March 23 | 11:15AM - 1:00PM
Poster Setup
Room: Frontenac ABC


Monday, March 23 | 11:15AM - 5:00PM
On Own for Lunch


Monday, March 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Frontenac ABC


Monday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Monday, March 23 | 5:00PM - 7:00PM
Quality Control in Mitochondria and the Metabolic Syndrome
Room: Macdonald DEF

Speaker 1 of 5
* Jodi Nunnari, University of California, Davis, USA

Monday, March 23 | 5:00PM - 7:00PM
Quality Control in Mitochondria and the Metabolic Syndrome
Room: Macdonald DEF

Speaker 2 of 5
Thomas Langer, CECAD Research Center, Germany
Mitochondrial Proteolysis and Metabolic Control

Monday, March 23 | 5:00PM - 7:00PM
Quality Control in Mitochondria and the Metabolic Syndrome
Room: Macdonald DEF

Speaker 3 of 5
Andrew G. Dillin, University of California, Berkeley, USA
Ablation of Olfactory Sensory Neurons Reprograms Peripheral Metabolism

Monday, March 23 | 5:00PM - 7:00PM
Quality Control in Mitochondria and the Metabolic Syndrome
Room: Macdonald DEF

Speaker 4 of 5
Jonathan R. Friedman, University of California, Davis, USA
Short Talk: MICOS, Respiratory Complexes and Mitochondrial Lipids Coordinately Build a Functional Mitochondrial Inner Membrane

Monday, March 23 | 5:00PM - 7:00PM
Quality Control in Mitochondria and the Metabolic Syndrome
Room: Macdonald DEF

Speaker 5 of 5
Benjamin D. Stein, The Salk Institute for Biological Studies, USA
Short Talk: Quantitative Proteomics Screen Using Stable Isotope Labeling in Mammals Identifies Novel AMPK Substrates in Mouse Liver

Monday, March 23 | 5:00PM - 7:00PM
Liver Metabolism in Human Health and Disease
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 1 of 4
* Samuel Klein, Washington University School of Medicine, USA
Metabolic Implications of NAFLD in Obesity


Monday, March 23 | 5:00PM - 7:00PM
Liver Metabolism in Human Health and Disease
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 2 of 4
Hannele Yki-Järvinen, University of Helsinki, Finland
NAFLD and Hepatic Insulin Resistance in the Human Liver


Monday, March 23 | 5:00PM - 7:00PM
Liver Metabolism in Human Health and Disease
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 3 of 4
Michael Roden, Universitätsklinikum Düsseldorf, Germany
Quantifying Hepatic Energetics in Health and Disease


Monday, March 23 | 5:00PM - 7:00PM
Liver Metabolism in Human Health and Disease
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 4 of 4
Elizabeth K. Speliotes, University of Michigan, USA
Short Talk: Genetic Variation in FXR/RXR Pathway Genes that Play a Role in Bile Acid, Cholesterol, Lipid and Carbohydrate Metabolism Predispose to Nonalcoholic Fatty Liver Disease in Humans


Monday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac ABC
No registration fees are used to fund alcohol served at this function.

Monday, March 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Frontenac ABC


Tuesday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac ABC


Tuesday, March 24 | 7:30AM - 8:00AM
Poster Setup
Room: Frontenac ABC


Tuesday, March 24 | 8:00AM - 5:00PM
Poster Viewing
Room: Frontenac ABC


Tuesday, March 24 | 8:00AM - 11:00AM
Gastrointestinal Lipid Signaling and the Metabolic Syndrome
(Joint)

Room: Macdonald ABCDEF

Speaker 1 of 6
* Anu Suomalainen Wartiovaara, University of Helsinki, Finland

Tuesday, March 24 | 8:00AM - 11:00AM
Gastrointestinal Lipid Signaling and the Metabolic Syndrome
(Joint)

Room: Macdonald ABCDEF

Speaker 2 of 6
Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
The Bile Acid Receptor TGR5 at the Crossroads of Inflammation and Metabolism

Tuesday, March 24 | 8:00AM - 11:00AM
Gastrointestinal Lipid Signaling and the Metabolic Syndrome
(Joint)

Room: Macdonald ABCDEF

Speaker 3 of 6
Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA
New Insights into NAFLD: Fructose, Fat and FGF21

Tuesday, March 24 | 8:00AM - 11:00AM
Gastrointestinal Lipid Signaling and the Metabolic Syndrome
(Joint)

Room: Macdonald ABCDEF

Speaker 4 of 6
David D. Moore, Baylor College of Medicine, USA
FXR as an Integrator of the Fed State in the Liver

Tuesday, March 24 | 8:00AM - 11:00AM
Gastrointestinal Lipid Signaling and the Metabolic Syndrome
(Joint)

Room: Macdonald ABCDEF

Speaker 5 of 6
Junichiro Sonoda, Regeneron Pharmaceuticals, Inc., USA
Stimulating Brown Fat with a Therapeutic Antibody

Tuesday, March 24 | 8:00AM - 11:00AM
Gastrointestinal Lipid Signaling and the Metabolic Syndrome
(Joint)

Room: Macdonald ABCDEF

Speaker 6 of 6
Allyson N. Hamlin, University of Cincinnati, USA
Short Talk: Hepatic LRP1 Deficiency Exacerbates Microsteatosis and Hepatocyte Cell Death via Lysosomal Insufficiency

Tuesday, March 24 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Tuesday, March 24 | 11:00AM - 12:00PM
Lunch
Room: Frontenac ABC


Tuesday, March 24 | 12:00PM - 2:30PM
Poster Session 2
Room: Frontenac ABC


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondria and Muscle
Room: Macdonald DEF

Speaker 1 of 8
* Reuben J. Shaw, The Salk Institute for Biological Studies, USA

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondria and Muscle
Room: Macdonald DEF

Speaker 2 of 8
Thomas Philip Agnew, University of Oxford, UK
oboe – A Novel Mouse Model of Mitochondrial Disease with Reduced Adiposity and Hypertrophic Cardiomyopathy

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondria and Muscle
Room: Macdonald DEF

Speaker 3 of 8
Weiwei Fan, The Salk Institute for Biological Studies, USA
Ppardelta-Mediated Shift in Muscle Mitochondrial Substrate Boosts Energy Expenditure and Attenuates Diet-Induced Obesity

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondria and Muscle
Room: Macdonald DEF

Speaker 4 of 8
David E. Cohen, Brigham and Women's Hospital, Harvard Medical School, USA
Thioesterase Superfamily Member 2 (Them2) Channels Fatty Acids to Glycerol-3-Phosphate Acyltransferase-1 (GPAT1): Role in Hepatic Insulin Resistance

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondria and Muscle
Room: Macdonald DEF

Speaker 5 of 8
Takashi Nakagawa, University of Toyama, Japan
NAD Synthesis Enzyme, Nmnat3 Protects against High Fat Diet- and Age-Induced Obesity in Mice

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondria and Muscle
Room: Macdonald DEF

Speaker 6 of 8
Eric S. Muise, Merck & Co., Inc., USA
Acute Treatment of Mice with Potent AMPK Activators Mimics Acute Exercise-Induced Transcriptional Effects in Skeletal Muscle

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondria and Muscle
Room: Macdonald DEF

Speaker 7 of 8
Mario Ost, German Institute of Human Nutrition, Germany
Muscle Mitohormesis Promotes Cellular Survival via Serine/Glycine Pathway Flux

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondria and Muscle
Room: Macdonald DEF

Speaker 8 of 8
Erin Quan Toyama, Genomics Institute of the Novartis Research Foundation, USA
AMPK Regulation of Mitochondrial Dynamics

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Junior Investigator Forum
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 1 of 9
* Peter A. Crawford, University of Minnesota, USA


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Junior Investigator Forum
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 2 of 9
William S. Baldwin, Clemson University, USA
Gender Differences in Response to a High-Fat Diet in CYP3A-null Mice


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Junior Investigator Forum
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 3 of 9
Guenter Haemmerle, University of Graz, Austria
Adipose Tissue Lipolysis Regulates G0S2 and FGF21 Expression in the Liver


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Junior Investigator Forum
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 4 of 9
Athan Kuliopulos, Oasis Pharmaceuticals, USA
Protease-Activated Receptor-2 (PAR2)–A Novel Therapeutic Target in Nonalcoholic Steatohepatitis (NASH)


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Junior Investigator Forum
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 5 of 9
Suresh T. Mathews, Auburn University, USA
AICAR Downregulates High Glucose-Induced Expression of Fetuin-A through AMPK-p38MAPK Axis in HepG2 Cells


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Junior Investigator Forum
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 6 of 9
James Xiaojun Rong, Lilly China Research & Development Center, China
Knockdown of Na+-Coupled Citrate Transporter Slc13a5 in Liver Decreased Body Weight and Improved Insulin Sensitivity in Mice with Pre-Existing Obese, Hyperglycemic Conditions


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Junior Investigator Forum
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 7 of 9
Takuya F. Sakaguchi, Cleveland Clinic, USA
Gain-of-Function Mutation in cmklr1, a Chemerin Receptor, Leads to Hepatic Steatosis and Inflammation in Zebrafish


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Junior Investigator Forum
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 8 of 9
Daniel F. Vatner, Yale University School of Medicine, USA
Substrate-Dependent Insulin-Independent Regulation of Hepatic Fatty Acid Esterification


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Junior Investigator Forum
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 9 of 9
Jim Perfield, Eli Lilly and Company, USA
Insight into the PPAR alpha-Dependent and –Independent Regulation of FGF21


Tuesday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Tuesday, March 24 | 5:00PM - 7:00PM
The Metabolic Syndrome: Insights from Rare Mitochondrial Dis
eases

Room: Macdonald DEF

Speaker 1 of 5
* Sadaf Farooqi, University of Cambridge, UK

Tuesday, March 24 | 5:00PM - 7:00PM
The Metabolic Syndrome: Insights from Rare Mitochondrial Dis
eases

Room: Macdonald DEF

Speaker 2 of 5
Anu Suomalainen Wartiovaara, University of Helsinki, Finland
Mitochondrial Dysfunction Modifies Nutrient Metabolism – Implications to Disease

Tuesday, March 24 | 5:00PM - 7:00PM
The Metabolic Syndrome: Insights from Rare Mitochondrial Dis
eases

Room: Macdonald DEF

Speaker 3 of 5
David Rand, Brown University, USA
Mitonuclear Genetic Interactions in Drosophila Aging and Disease

Tuesday, March 24 | 5:00PM - 7:00PM
The Metabolic Syndrome: Insights from Rare Mitochondrial Dis
eases

Room: Macdonald DEF

Speaker 4 of 5
Douglas C. Wallace, Children's Hospital of Philadelphia, USA
A Mitochondrial Diseases – The Paradigms

Tuesday, March 24 | 5:00PM - 7:00PM
The Metabolic Syndrome: Insights from Rare Mitochondrial Dis
eases

Room: Macdonald DEF

Speaker 5 of 5
Iliana A. Chatzispyrou, Academic Medical Centre, Netherlands
Short Talk: Identification of a Novel Mutation for Perrault Syndrome in the Mitochondrial rRNA Chaperone ERAL1

Tuesday, March 24 | 5:00PM - 7:00PM
Pathways to NASH, Fibrosis and Hepatocullular Carcinoma
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 1 of 5
* Brent A. Tetri, St. Louis University, USA


Tuesday, March 24 | 5:00PM - 7:00PM
Pathways to NASH, Fibrosis and Hepatocullular Carcinoma
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 2 of 5
Anna Mae Diehl, Duke University, USA
Hedgehog Signaling and Hepatic Fibrosis


Tuesday, March 24 | 5:00PM - 7:00PM
Pathways to NASH, Fibrosis and Hepatocullular Carcinoma
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 3 of 5
Gyongyi Szabo, University of Massachusetts Medical School, USA
Metabolic Danger Signals in Immune Cell and Hepatocyte Crosstalk in NASH


Tuesday, March 24 | 5:00PM - 7:00PM
Pathways to NASH, Fibrosis and Hepatocullular Carcinoma
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 4 of 5
Roger J. Davis, HHMI/University of Massachusetts Medical School, USA
Metabolic Stress Signaling Mediated by JNK


Tuesday, March 24 | 5:00PM - 7:00PM
Pathways to NASH, Fibrosis and Hepatocullular Carcinoma
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 5 of 5
Maria E. Moreno-Fernandez, Cincinnati Children's Hospital, USA
Short Talk: Role of the IL-17 Axis in the Progression of Non-Alcoholic Fatty Liver Disease


Tuesday, March 24 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac ABC


Wednesday, March 25 | 8:00AM - 11:00AM
Genetics of the Metabolic Syndrome
Room: Macdonald DEF

Speaker 1 of 5
* David Rand, Brown University, USA

Wednesday, March 25 | 8:00AM - 11:00AM
Genetics of the Metabolic Syndrome
Room: Macdonald DEF

Speaker 2 of 5
Norbert Perrimon, Harvard Medical School, USA
Discovery of in vivo Regulators of Glucagon-Induced Hyperglycemia

Wednesday, March 25 | 8:00AM - 11:00AM
Genetics of the Metabolic Syndrome
Room: Macdonald DEF

Speaker 3 of 5
Jose Antonio Enríquez, Centro Nacional de Investigaciones, Spain
Talk Title to be Announced

Wednesday, March 25 | 8:00AM - 11:00AM
Genetics of the Metabolic Syndrome
Room: Macdonald DEF

Speaker 4 of 5
Chris Day, Newcastle University, UK
Genetic of NAFLD

Wednesday, March 25 | 8:00AM - 11:00AM
Genetics of the Metabolic Syndrome
Room: Macdonald DEF

Speaker 5 of 5
Sadaf Farooqi, University of Cambridge, UK
Genetic Basis of Severe Obesity

Wednesday, March 25 | 8:00AM - 11:00AM
Extra-Hepatic Regulation of Liver Metabolism
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 1 of 6
* Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA


Wednesday, March 25 | 8:00AM - 11:00AM
Extra-Hepatic Regulation of Liver Metabolism
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 2 of 6
Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
Role of Distinct Ceramide Species in Obesity-Associated Insulin Resistance


Wednesday, March 25 | 8:00AM - 11:00AM
Extra-Hepatic Regulation of Liver Metabolism
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 3 of 6
Frank J. Gonzalez, National Institutes of Health, USA
The Gut Microbiota Influences NAFLD thorough Intestinal FXR Signaling


Wednesday, March 25 | 8:00AM - 11:00AM
Extra-Hepatic Regulation of Liver Metabolism
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 4 of 6
George N. Ioannou, University of Washington, USA
Role of Cholesterol in the Progression of Steatosis to NASH


Wednesday, March 25 | 8:00AM - 11:00AM
Extra-Hepatic Regulation of Liver Metabolism
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 5 of 6
Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
Metabolic FGFs 15/19 and 21: From Physiology to Pharmacology


Wednesday, March 25 | 8:00AM - 11:00AM
Extra-Hepatic Regulation of Liver Metabolism
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 6 of 6
Mattias Bergentall, Gothenburg University, Sweden
Short Talk: The Gut Microbiota Modulates Sucrose-Induced NAFLD


Wednesday, March 25 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Wednesday, March 25 | 11:00AM - 1:00PM
Poster Setup
Room: Frontenac ABC


Wednesday, March 25 | 11:00AM - 2:30PM
On Own for Lunch


Wednesday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Frontenac ABC


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: Disease Mechanism and Therapy
Room: Macdonald DEF

Speaker 1 of 8
* Junichiro Sonoda, Regeneron Pharmaceuticals, Inc., USA

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: Disease Mechanism and Therapy
Room: Macdonald DEF

Speaker 2 of 8
Laurent Mouchiroud, École Polytechnique Federale de Lausanne – EPFL, Switzerland
Urolithin A Improves Fitness and Lifespan through Mitophagy

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: Disease Mechanism and Therapy
Room: Macdonald DEF

Speaker 3 of 8
Elizabeth K. Speliotes, University of Michigan, USA
Human Genetic Variants In or Near Mitochondrial Genes Uncouple Obesity from Metabolic Disease

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: Disease Mechanism and Therapy
Room: Macdonald DEF

Speaker 4 of 8
Kevin G. Becker, NIA, National Institutes of Health, USA
The Effects of Tomatidine on Three Cell Models of Differentiation

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: Disease Mechanism and Therapy
Room: Macdonald DEF

Speaker 5 of 8
Andrea Galmozzi, The Scripps Research Institute, USA
ThermoMouse: An in vivo Model to Identify Modulators of UCP1 Expression in Brown Adipose Tissue

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: Disease Mechanism and Therapy
Room: Macdonald DEF

Speaker 6 of 8
Ambar Grijalva, Columbia University, USA
Lipid Accumulation in Adipose Tissue Macrophages Reveals a Non-Classical Regulated Pathway of Lipid Release in Adipocytes

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: Disease Mechanism and Therapy
Room: Macdonald DEF

Speaker 7 of 8
Stefan G. Kauschke, Boehringer Ingelheim Pharma, Germany
Evaluation of BACE2 Inhibitors to Delay Progression of beta-Cell Failure in T2DM

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: Disease Mechanism and Therapy
Room: Macdonald DEF

Speaker 8 of 8
Yael Kuperman, Weizmann Institute, Israel
CRFR1 Inhibits AgRP Neurons to Allow Appropriate Sympathetic Nervous System Activity following Challenge

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: NAFLD Therapeutics
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 1 of 9
* Henry N. Ginsberg, Columbia University College of Physicians and Surgeons, USA


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: NAFLD Therapeutics
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 2 of 9
Michael L. Chouinard, Eli Lilly and Company, USA
Established Therapies for Diabetes and Dyslipidemia Aimed at CYP7A1 Induction Are Vulnerable to FXR Modulation by Nutrient Fat, Perhaps Limiting their Use in Non-alcoholic Steatohepatitis (NASH)


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: NAFLD Therapeutics
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 3 of 9
Derek M. Erion, Takeda, USA
DGAT2 Inhibition Prevents NAFLD and Fibrosis in the STAM Mouse Model of NASH


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: NAFLD Therapeutics
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 4 of 9
Tadasuke Komori, Wakayama Medical University, Japan
The Roles of Oncostatin M in the Treatment of Nonalcoholic Fatty Liver Disease in Mice


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: NAFLD Therapeutics
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 5 of 9
Xiaoxin Wang, University of Colorado Denver, USA
Treatment with the FXR-TGR5 Dual Agonist INT-767 Decreases NAFLD-NASH in Mice Fed a Western Diet


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: NAFLD Therapeutics
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 6 of 9
Eyal Breitbart, VBL Therapeutics, Israel
TLR4 Complex Antagonist Inhibits Non-Alcoholic Steatohepatitis (NASH) and Liver Fibrosis


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: NAFLD Therapeutics
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 7 of 9
Narayanan Hariharan, Tekmira Pharmaceuticals, Canada
Novel RNAi-Lipid Nanoparticle Therapeutics for Hypertriglyceridemia


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: NAFLD Therapeutics
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 8 of 9
Moshe Levi, Georgetown University, USA
Bile Acid Sequestrant Prevents NAFLD/NASH in Diet-Induced Obesity and Insulin Resistant Mice


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 2: NAFLD Therapeutics
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 9 of 9
Mukul R. Jain, Zydus Research Centre, India
Efficacy of Saroglitazar, a Novel PPAR alpha/gamma Agonist in a Mouse Model of Non-Alcoholic Steatohepatitis


Wednesday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Wednesday, March 25 | 5:00PM - 7:00PM
Therapy of the Metabolic Syndrome
Room: Macdonald DEF

Speaker 1 of 5
* Ajay Chawla, Merck Research Labs, USA

Wednesday, March 25 | 5:00PM - 7:00PM
Therapy of the Metabolic Syndrome
Room: Macdonald DEF

Speaker 2 of 5
Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany
Novel Poly-Pharmacy for the Treatment of Obesity and Diabetes

Wednesday, March 25 | 5:00PM - 7:00PM
Therapy of the Metabolic Syndrome
Room: Macdonald DEF

Speaker 3 of 5
Patrick R. Griffin, The Scripps Research Institute, USA
Pharmacological Repression of PPARG Improves Metabolic Parameters and Promotes Osteogenesis

Wednesday, March 25 | 5:00PM - 7:00PM
Therapy of the Metabolic Syndrome
Room: Macdonald DEF

Speaker 4 of 5
Saswata Talukdar, Merck Sharp & Dohme, USA
Chronic Administration of a Long-Acting FGF21 Molecule PF-05231023 Decreases Body Weight and Improves Metabolic Profile in Non-Human Primates and Subjects with Type 2 Diabetes

Wednesday, March 25 | 5:00PM - 7:00PM
Therapy of the Metabolic Syndrome
Room: Macdonald DEF

Speaker 5 of 5
Riekelt H. Houtkooper, Academic Medical Center, Netherlands
Short Talk: Tetracycline-Dependent Mitochondrial Dysfunction Confounds Research and Poses an Environmental Hazard

Wednesday, March 25 | 5:00PM - 7:00PM
Regulatory Nodes of Hepatic Energy Metabolism
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 1 of 5
* Douglas G. Mashek, University of Minnesota, USA


Wednesday, March 25 | 5:00PM - 7:00PM
Regulatory Nodes of Hepatic Energy Metabolism
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 2 of 5
Reuben J. Shaw, The Salk Institute for Biological Studies, USA
AMPK: Central Integrator of Metabolic Adaptation and Mitochondrial Homeostasis


Wednesday, March 25 | 5:00PM - 7:00PM
Regulatory Nodes of Hepatic Energy Metabolism
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 3 of 5
Anders M. Näär, University of California, Berkeley, USA


Wednesday, March 25 | 5:00PM - 7:00PM
Regulatory Nodes of Hepatic Energy Metabolism
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 4 of 5
Peter A. Crawford, University of Minnesota, USA
Ketone Metabolism and Hepatic Energy Homeostasis in the Absorptive State


Wednesday, March 25 | 5:00PM - 7:00PM
Regulatory Nodes of Hepatic Energy Metabolism
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 5 of 5
Geula Hanin, Hebrew University, Israel
Short Talk: MicroRNA-132 Is a Reversible Amplifier of Hepatic Lipid Accumulation


Wednesday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac ABC
No registration fees are used to fund alcohol served at this function.

Wednesday, March 25 | 7:30PM - 10:00PM
Poster Session 3
Room: Frontenac ABC


Thursday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac ABC


Thursday, March 26 | 8:00AM - 11:00AM
Metabolic Inflammation, Mitochondria and Metabolic Disease
Room: Macdonald DEF

Speaker 1 of 6
* Juleen R. Zierath, Karolinska Institutet, Sweden

Thursday, March 26 | 8:00AM - 11:00AM
Metabolic Inflammation, Mitochondria and Metabolic Disease
Room: Macdonald DEF

Speaker 2 of 6
Ajay Chawla, Merck Research Labs, USA
Innate Control of Metabolism

Thursday, March 26 | 8:00AM - 11:00AM
Metabolic Inflammation, Mitochondria and Metabolic Disease
Room: Macdonald DEF

Speaker 3 of 6
Takashi Kadowaki, University of Tokyo, Japan
Adiponectin Receptor and Metabolic Syndrome: Pathophysiology and Therapeutic Strategy

Thursday, March 26 | 8:00AM - 11:00AM
Metabolic Inflammation, Mitochondria and Metabolic Disease
Room: Macdonald DEF

Speaker 4 of 6
Anthony W. Ferrante, Columbia University, USA
Immune Regulation of Systemic Metabolism

Thursday, March 26 | 8:00AM - 11:00AM
Metabolic Inflammation, Mitochondria and Metabolic Disease
Room: Macdonald DEF

Speaker 5 of 6
Keir J. Menzies, University of Ottawa, Canada
Short Talk: NAD+ Repletion Improves the Mdx Mouse Muscle Phenotype by Countering Increased Levels of PARylation

Thursday, March 26 | 8:00AM - 11:00AM
Metabolic Inflammation, Mitochondria and Metabolic Disease
Room: Macdonald DEF

Speaker 6 of 6
Rudolf J. Wiesner, University of Cologne, Germany
Short Talk: Inhibition of Mitochondrial Complex I by Metformin Induces a Futile Lactate Cycle, which Increases Energy Expenditure and Slows Down Development of Type 2 Diabetes (T2DM)

Thursday, March 26 | 8:00AM - 11:00AM
TAG Synthesis and Turnover
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 1 of 6
* Brian N. Finck, Washington University School of Medicine, USA


Thursday, March 26 | 8:00AM - 11:00AM
TAG Synthesis and Turnover
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 2 of 6
Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Hepatic Lipid Synthesis and Insulin Resistance


Thursday, March 26 | 8:00AM - 11:00AM
TAG Synthesis and Turnover
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 3 of 6
Douglas G. Mashek, University of Minnesota, USA
TAG Hydrolysis as a Branch Point in Hepatic Metabolism


Thursday, March 26 | 8:00AM - 11:00AM
TAG Synthesis and Turnover
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 4 of 6
Robert V. Farese Jr., Harvard School of Public Health, USA
Mechanisms and Consequences of Lipid Storage


Thursday, March 26 | 8:00AM - 11:00AM
TAG Synthesis and Turnover
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 5 of 6
Elizabeth J. Parks, University of Missouri, USA
In vivo Quantitation of Intracellular TAG Assembly in Humans


Thursday, March 26 | 8:00AM - 11:00AM
TAG Synthesis and Turnover
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 6 of 6
Ryan J. Schulze, Mayo Clinic, USA
Short Talk: Small GTPases as Regulators of Hepatocellular Lipophagy


Thursday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Thursday, March 26 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Thursday, March 26 | 5:00PM - 6:45PM
Metabolic Syndrome and Muscle Energy Homeostasis
Room: Macdonald DEF

Speaker 1 of 4
* David D. Moore, Baylor College of Medicine, USA

Thursday, March 26 | 5:00PM - 6:45PM
Metabolic Syndrome and Muscle Energy Homeostasis
Room: Macdonald DEF

Speaker 2 of 4
Julie St-Pierre, McGill University, Canada
Modulation of Mitochondrial Metabolism and Cellular Bioenergetics


Thursday, March 26 | 5:00PM - 6:45PM
Metabolic Syndrome and Muscle Energy Homeostasis
Room: Macdonald DEF

Speaker 3 of 4
Juleen R. Zierath, Karolinska Institutet, Sweden
Altered DNA Methylation of Glycolytic and Lipogenic Genes in Skeletal Muscle and Liver from Obese and Type 2 Diabetic Patients

Thursday, March 26 | 5:00PM - 6:45PM
Metabolic Syndrome and Muscle Energy Homeostasis
Room: Macdonald DEF

Speaker 4 of 4
Satchidananda Panda, The Salk Institute for Biological Studies, USA
Eating Pattern and Metabolic Diseases

Thursday, March 26 | 5:00PM - 6:45PM
Hepatic Metabolic Alterations Associated with NAFLD
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 1 of 4
* Jay D. Horton, University of Texas Southwestern Medical Center, USA


Thursday, March 26 | 5:00PM - 6:45PM
Hepatic Metabolic Alterations Associated with NAFLD
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 2 of 4
Jay D. Horton, University of Texas Southwestern Medical Center, USA
Molecular Mediators of Nonalcoholic Fatty Liver Disease


Thursday, March 26 | 5:00PM - 6:45PM
Hepatic Metabolic Alterations Associated with NAFLD
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 3 of 4
Mark A. Herman, Duke University Medical Center, USA
ChREBP Isoforms Link Glucose and Lipid Metabolism


Thursday, March 26 | 5:00PM - 6:45PM
Hepatic Metabolic Alterations Associated with NAFLD
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABC

Speaker 4 of 4
Henry N. Ginsberg, Columbia University College of Physicians and Surgeons, USA
Role of Autophagy in Hepatic Lipid Homeostasis


Thursday, March 26 | 6:45PM - 7:00PM
Meeting Wrap Up: Outcomes and Future Directions (Organizers)
Room: Macdonald ABCDEF


Thursday, March 26 | 6:45PM - 7:00PM
Meeting Wrap Up: Outcomes and Future Directions (Organizers)
This session is from Liver Metabolism & NAFLD
Room: Macdonald ABCDEF


Thursday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac ABC
No registration fees are used to fund alcohol served at this function.

Thursday, March 26 | 8:00PM - 11:00PM
Entertainment
Room: Frontenac ABC
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 26 | 8:00PM - 11:00PM
Cash Bar
Room: Frontenac ABC


Friday, March 27 | 10:25AM - 10:25AM
Departure


*Session Chair.