Past Meeting | Keystone Symposia

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Obesity and the Metabolic Syndrome: Mitochondria and Energy Expenditure joint with Liver Metabolism and Nonalcoholic Fatty Liver Disease (NAFLD) Organizer(s): Johan Auwerx, Eleftheria Maratos-Flier and Thomas Langer Date: March 22 - 27, 2015 Location: Fairmont Chateau Whistler, Whistler, BC, Canada Sponsored by Nestlé Institute of Health Sciences and Novo Nordisk A/S Summary of Meeting: A medical challenge of the 21st century is the coupling of an unprecedented increase in life expectancy with a large increase in incidence and prevalence of chronic multifactorial diseases. Classic disease examples include disorders of metabolism such as obesity and type 2 diabetes mellitus, which are often associated with co-morbidities including non-alcoholic liver disease and coronary, peripheral and central vascular disease. Collectively, the spectrum of disorders is often referred to as the metabolic syndrome. Over the past decade, it has become evident that shifts in cellular metabolism are often linked to changes in the number, morphology and function of mitochondria, and that these cellular changes underlie systemic metabolic abnormalities that characterize the many clinical features of the metabolic syndrome. This meeting will discuss novel findings that link mitochondrial function in peripheral tissues, such as liver, muscle and gut, with the systemic abnormalities of the metabolic syndrome. The potential for identifying new therapeutics that are based on modifying mitochondrial function will be reviewed. As mitochondrial function is now acknowledged to also control metabolic homeostasis on an organismal level in addition to controlling energy homeostasis at the cellular level, this meeting will create a truly interdisciplinary environment that brings together basic scientists in the fields of bioenergetics, physiology, and mitochondrial and cell biology, and clinicians with an interest in metabolic disease, to foster innovative ideas in this area. Scholarship Deadline: November 20 2014 Discounted Abstract Deadline: November 20 2014 Abstract Deadline: December 18 2014 Discounted Registration Deadline: January 21 2015 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Grant No. 5R13DK104611-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Obesity and the Metabolic Syndrome: Mitochondria and Energy Expenditure

joint with Liver Metabolism and Nonalcoholic Fatty Liver Disease (NAFLD)

Organizer(s): Johan Auwerx, Eleftheria Maratos-Flier and Thomas Langer

Date: March 22 - 27, 2015
Location: Fairmont Chateau Whistler, Whistler, BC, Canada

Sponsored by Nestlé Institute of Health Sciences and Novo Nordisk A/S

Summary of Meeting:

A medical challenge of the 21st century is the coupling of an unprecedented increase in life expectancy with a large increase in incidence and prevalence of chronic multifactorial diseases. Classic disease examples include disorders of metabolism such as obesity and type 2 diabetes mellitus, which are often associated with co-morbidities including non-alcoholic liver disease and coronary, peripheral and central vascular disease. Collectively, the spectrum of disorders is often referred to as the metabolic syndrome. Over the past decade, it has become evident that shifts in cellular metabolism are often linked to changes in the number, morphology and function of mitochondria, and that these cellular changes underlie systemic metabolic abnormalities that characterize the many clinical features of the metabolic syndrome. This meeting will discuss novel findings that link mitochondrial function in peripheral tissues, such as liver, muscle and gut, with the systemic abnormalities of the metabolic syndrome. The potential for identifying new therapeutics that are based on modifying mitochondrial function will be reviewed. As mitochondrial function is now acknowledged to also control metabolic homeostasis on an organismal level in addition to controlling energy homeostasis at the cellular level, this meeting will create a truly interdisciplinary environment that brings together basic scientists in the fields of bioenergetics, physiology, and mitochondrial and cell biology, and clinicians with an interest in metabolic disease, to foster innovative ideas in this area.

Scholarship Deadline: November 20 2014

Discounted Abstract Deadline: November 20 2014

Abstract Deadline: December 18 2014

Discounted Registration Deadline: January 21 2015

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK104611-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 22 \| 4:00PM - 8:00PM Arrival and Registration Room: Macdonald Foyer
Sunday, March 22 \| 6:00PM - 8:00PM Welcome Mixer Room: Macdonald Foyer No registration fees are used to fund alcohol served at this function.
Monday, March 23 \| 7:00AM - 8:00AM Breakfast Room: Frontenac ABC
Monday, March 23 \| 8:00AM - 9:00AM Keynote Address Room: Macdonald DEF Speaker 1 of 2 * Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
Monday, March 23 \| 8:00AM - 9:00AM Keynote Address Room: Macdonald DEF Speaker 2 of 2 Jodi Nunnari, University of California, Davis, USA Molecular Mechanisms of Mitochondrial Behavior
Monday, March 23 \| 9:00AM - 11:15AM Mitochondrial Function and Morphology and the Metabolic Synd rome Room: Macdonald DEF Speaker 1 of 4 * Andrew G. Dillin, University of California, Berkeley, USA
Monday, March 23 \| 9:00AM - 11:15AM Mitochondrial Function and Morphology and the Metabolic Synd rome Room: Macdonald DEF Speaker 2 of 4 Orian S. Shirihai, University of California, Los Angeles, USA Mitochondrial Fission/Fusion and Pancreatic Function
Monday, March 23 \| 9:00AM - 11:15AM Mitochondrial Function and Morphology and the Metabolic Synd rome Room: Macdonald DEF Speaker 3 of 4 David C. Chan, California Institute of Technology, USA Regulation of Mitochondrial Fusion
Monday, March 23 \| 9:00AM - 11:15AM Mitochondrial Function and Morphology and the Metabolic Synd rome Room: Macdonald DEF Speaker 4 of 4 Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland Mitonuclear Protein Balance as a Determinant of Health- and Lifespan
Monday, March 23 \| 9:00AM - 11:15AM Hepatic Flux in NAFLD This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 1 of 4 * Jay D. Horton, University of Texas Southwestern Medical Center, USA
Monday, March 23 \| 9:00AM - 11:15AM Hepatic Flux in NAFLD This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 2 of 4 Shawn C. Burgess, University of Texas Southwestern Medical Center, USA Obesity’s Beast of Burden
Monday, March 23 \| 9:00AM - 11:15AM Hepatic Flux in NAFLD This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 3 of 4 Brian N. Finck, Washington University School of Medicine, USA New Pathways for Targeting Metabolic Disease and Hepatic Steatosis
Monday, March 23 \| 9:00AM - 11:15AM Hepatic Flux in NAFLD This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 4 of 4 Eric B. Taylor, University of Iowa, USA Regulation of Hepatic Gluconeogenesis by Mitochondrial Pyruvate Carrier 1
Monday, March 23 \| 9:40AM - 10:00AM Coffee Break Room: Macdonald Foyer
Monday, March 23 \| 11:15AM - 1:00PM Poster Setup Room: Frontenac ABC
Monday, March 23 \| 11:15AM - 5:00PM On Own for Lunch
Monday, March 23 \| 1:00PM - 10:00PM Poster Viewing Room: Frontenac ABC
Monday, March 23 \| 4:30PM - 5:00PM Coffee Available Room: Macdonald Foyer
Monday, March 23 \| 5:00PM - 7:00PM Quality Control in Mitochondria and the Metabolic Syndrome Room: Macdonald DEF Speaker 1 of 5 * Jodi Nunnari, University of California, Davis, USA
Monday, March 23 \| 5:00PM - 7:00PM Quality Control in Mitochondria and the Metabolic Syndrome Room: Macdonald DEF Speaker 2 of 5 Thomas Langer, CECAD Research Center, Germany Mitochondrial Proteolysis and Metabolic Control
Monday, March 23 \| 5:00PM - 7:00PM Quality Control in Mitochondria and the Metabolic Syndrome Room: Macdonald DEF Speaker 3 of 5 Andrew G. Dillin, University of California, Berkeley, USA Ablation of Olfactory Sensory Neurons Reprograms Peripheral Metabolism
Monday, March 23 \| 5:00PM - 7:00PM Quality Control in Mitochondria and the Metabolic Syndrome Room: Macdonald DEF Speaker 4 of 5 Jonathan R. Friedman, University of California, Davis, USA Short Talk: MICOS, Respiratory Complexes and Mitochondrial Lipids Coordinately Build a Functional Mitochondrial Inner Membrane
Monday, March 23 \| 5:00PM - 7:00PM Quality Control in Mitochondria and the Metabolic Syndrome Room: Macdonald DEF Speaker 5 of 5 Benjamin D. Stein, The Salk Institute for Biological Studies, USA Short Talk: Quantitative Proteomics Screen Using Stable Isotope Labeling in Mammals Identifies Novel AMPK Substrates in Mouse Liver
Monday, March 23 \| 5:00PM - 7:00PM Liver Metabolism in Human Health and Disease This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 1 of 4 * Samuel Klein, Washington University School of Medicine, USA Metabolic Implications of NAFLD in Obesity
Monday, March 23 \| 5:00PM - 7:00PM Liver Metabolism in Human Health and Disease This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 2 of 4 Hannele Yki-Järvinen, University of Helsinki, Finland NAFLD and Hepatic Insulin Resistance in the Human Liver
Monday, March 23 \| 5:00PM - 7:00PM Liver Metabolism in Human Health and Disease This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 3 of 4 Michael Roden, Universitätsklinikum Düsseldorf, Germany Quantifying Hepatic Energetics in Health and Disease
Monday, March 23 \| 5:00PM - 7:00PM Liver Metabolism in Human Health and Disease This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 4 of 4 Elizabeth K. Speliotes, University of Michigan, USA Short Talk: Genetic Variation in FXR/RXR Pathway Genes that Play a Role in Bile Acid, Cholesterol, Lipid and Carbohydrate Metabolism Predispose to Nonalcoholic Fatty Liver Disease in Humans
Monday, March 23 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Frontenac ABC No registration fees are used to fund alcohol served at this function.
Monday, March 23 \| 7:30PM - 10:00PM Poster Session 1 Room: Frontenac ABC
Tuesday, March 24 \| 7:00AM - 8:00AM Breakfast Room: Frontenac ABC
Tuesday, March 24 \| 7:30AM - 8:00AM Poster Setup Room: Frontenac ABC
Tuesday, March 24 \| 8:00AM - 5:00PM Poster Viewing Room: Frontenac ABC
Tuesday, March 24 \| 8:00AM - 11:00AM Gastrointestinal Lipid Signaling and the Metabolic Syndrome (Joint) Room: Macdonald ABCDEF Speaker 1 of 6 * Anu Suomalainen Wartiovaara, University of Helsinki, Finland
Tuesday, March 24 \| 8:00AM - 11:00AM Gastrointestinal Lipid Signaling and the Metabolic Syndrome (Joint) Room: Macdonald ABCDEF Speaker 2 of 6 Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland The Bile Acid Receptor TGR5 at the Crossroads of Inflammation and Metabolism
Tuesday, March 24 \| 8:00AM - 11:00AM Gastrointestinal Lipid Signaling and the Metabolic Syndrome (Joint) Room: Macdonald ABCDEF Speaker 3 of 6 Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA New Insights into NAFLD: Fructose, Fat and FGF21
Tuesday, March 24 \| 8:00AM - 11:00AM Gastrointestinal Lipid Signaling and the Metabolic Syndrome (Joint) Room: Macdonald ABCDEF Speaker 4 of 6 David D. Moore, Baylor College of Medicine, USA FXR as an Integrator of the Fed State in the Liver
Tuesday, March 24 \| 8:00AM - 11:00AM Gastrointestinal Lipid Signaling and the Metabolic Syndrome (Joint) Room: Macdonald ABCDEF Speaker 5 of 6 Junichiro Sonoda, Regeneron Pharmaceuticals, Inc., USA Stimulating Brown Fat with a Therapeutic Antibody
Tuesday, March 24 \| 8:00AM - 11:00AM Gastrointestinal Lipid Signaling and the Metabolic Syndrome (Joint) Room: Macdonald ABCDEF Speaker 6 of 6 Allyson N. Hamlin, University of Cincinnati, USA Short Talk: Hepatic LRP1 Deficiency Exacerbates Microsteatosis and Hepatocyte Cell Death via Lysosomal Insufficiency
Tuesday, March 24 \| 9:20AM - 9:40AM Coffee Break Room: Macdonald Foyer
Tuesday, March 24 \| 11:00AM - 12:00PM Lunch Room: Frontenac ABC
Tuesday, March 24 \| 12:00PM - 2:30PM Poster Session 2 Room: Frontenac ABC
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Mitochondria and Muscle Room: Macdonald DEF Speaker 1 of 8 * Reuben J. Shaw, The Salk Institute for Biological Studies, USA
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Mitochondria and Muscle Room: Macdonald DEF Speaker 2 of 8 Thomas Philip Agnew, University of Oxford, UK oboe – A Novel Mouse Model of Mitochondrial Disease with Reduced Adiposity and Hypertrophic Cardiomyopathy
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Mitochondria and Muscle Room: Macdonald DEF Speaker 3 of 8 Weiwei Fan, The Salk Institute for Biological Studies, USA Ppardelta-Mediated Shift in Muscle Mitochondrial Substrate Boosts Energy Expenditure and Attenuates Diet-Induced Obesity
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Mitochondria and Muscle Room: Macdonald DEF Speaker 4 of 8 David E. Cohen, Brigham and Women's Hospital, Harvard Medical School, USA Thioesterase Superfamily Member 2 (Them2) Channels Fatty Acids to Glycerol-3-Phosphate Acyltransferase-1 (GPAT1): Role in Hepatic Insulin Resistance
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Mitochondria and Muscle Room: Macdonald DEF Speaker 5 of 8 Takashi Nakagawa, University of Toyama, Japan NAD Synthesis Enzyme, Nmnat3 Protects against High Fat Diet- and Age-Induced Obesity in Mice
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Mitochondria and Muscle Room: Macdonald DEF Speaker 6 of 8 Eric S. Muise, Merck & Co., Inc., USA Acute Treatment of Mice with Potent AMPK Activators Mimics Acute Exercise-Induced Transcriptional Effects in Skeletal Muscle
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Mitochondria and Muscle Room: Macdonald DEF Speaker 7 of 8 Mario Ost, German Institute of Human Nutrition, Germany Muscle Mitohormesis Promotes Cellular Survival via Serine/Glycine Pathway Flux
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Mitochondria and Muscle Room: Macdonald DEF Speaker 8 of 8 Erin Quan Toyama, Genomics Institute of the Novartis Research Foundation, USA AMPK Regulation of Mitochondrial Dynamics
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Junior Investigator Forum This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 1 of 9 * Peter A. Crawford, University of Minnesota, USA
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Junior Investigator Forum This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 2 of 9 William S. Baldwin, Clemson University, USA Gender Differences in Response to a High-Fat Diet in CYP3A-null Mice
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Junior Investigator Forum This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 3 of 9 Guenter Haemmerle, University of Graz, Austria Adipose Tissue Lipolysis Regulates G0S2 and FGF21 Expression in the Liver
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Junior Investigator Forum This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 4 of 9 Athan Kuliopulos, Oasis Pharmaceuticals, USA Protease-Activated Receptor-2 (PAR2)–A Novel Therapeutic Target in Nonalcoholic Steatohepatitis (NASH)
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Junior Investigator Forum This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 5 of 9 Suresh T. Mathews, Auburn University, USA AICAR Downregulates High Glucose-Induced Expression of Fetuin-A through AMPK-p38MAPK Axis in HepG2 Cells
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Junior Investigator Forum This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 6 of 9 James Xiaojun Rong, Lilly China Research & Development Center, China Knockdown of Na+-Coupled Citrate Transporter Slc13a5 in Liver Decreased Body Weight and Improved Insulin Sensitivity in Mice with Pre-Existing Obese, Hyperglycemic Conditions
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Junior Investigator Forum This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 7 of 9 Takuya F. Sakaguchi, Cleveland Clinic, USA Gain-of-Function Mutation in cmklr1, a Chemerin Receptor, Leads to Hepatic Steatosis and Inflammation in Zebrafish
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Junior Investigator Forum This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 8 of 9 Daniel F. Vatner, Yale University School of Medicine, USA Substrate-Dependent Insulin-Independent Regulation of Hepatic Fatty Acid Esterification
Tuesday, March 24 \| 2:30PM - 4:30PM Workshop 1: Junior Investigator Forum This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 9 of 9 Jim Perfield, Eli Lilly and Company, USA Insight into the PPAR alpha-Dependent and –Independent Regulation of FGF21
Tuesday, March 24 \| 4:30PM - 5:00PM Coffee Available Room: Macdonald Foyer
Tuesday, March 24 \| 5:00PM - 7:00PM The Metabolic Syndrome: Insights from Rare Mitochondrial Dis eases Room: Macdonald DEF Speaker 1 of 5 * Sadaf Farooqi, University of Cambridge, UK
Tuesday, March 24 \| 5:00PM - 7:00PM The Metabolic Syndrome: Insights from Rare Mitochondrial Dis eases Room: Macdonald DEF Speaker 2 of 5 Anu Suomalainen Wartiovaara, University of Helsinki, Finland Mitochondrial Dysfunction Modifies Nutrient Metabolism – Implications to Disease
Tuesday, March 24 \| 5:00PM - 7:00PM The Metabolic Syndrome: Insights from Rare Mitochondrial Dis eases Room: Macdonald DEF Speaker 3 of 5 David Rand, Brown University, USA Mitonuclear Genetic Interactions in Drosophila Aging and Disease
Tuesday, March 24 \| 5:00PM - 7:00PM The Metabolic Syndrome: Insights from Rare Mitochondrial Dis eases Room: Macdonald DEF Speaker 4 of 5 Douglas C. Wallace, Children's Hospital of Philadelphia, USA A Mitochondrial Diseases – The Paradigms
Tuesday, March 24 \| 5:00PM - 7:00PM The Metabolic Syndrome: Insights from Rare Mitochondrial Dis eases Room: Macdonald DEF Speaker 5 of 5 Iliana A. Chatzispyrou, Academic Medical Centre, Netherlands Short Talk: Identification of a Novel Mutation for Perrault Syndrome in the Mitochondrial rRNA Chaperone ERAL1
Tuesday, March 24 \| 5:00PM - 7:00PM Pathways to NASH, Fibrosis and Hepatocullular Carcinoma This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 1 of 5 * Brent A. Tetri, St. Louis University, USA
Tuesday, March 24 \| 5:00PM - 7:00PM Pathways to NASH, Fibrosis and Hepatocullular Carcinoma This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 2 of 5 Anna Mae Diehl, Duke University, USA Hedgehog Signaling and Hepatic Fibrosis
Tuesday, March 24 \| 5:00PM - 7:00PM Pathways to NASH, Fibrosis and Hepatocullular Carcinoma This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 3 of 5 Gyongyi Szabo, University of Massachusetts Medical School, USA Metabolic Danger Signals in Immune Cell and Hepatocyte Crosstalk in NASH
Tuesday, March 24 \| 5:00PM - 7:00PM Pathways to NASH, Fibrosis and Hepatocullular Carcinoma This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 4 of 5 Roger J. Davis, HHMI/University of Massachusetts Medical School, USA Metabolic Stress Signaling Mediated by JNK
Tuesday, March 24 \| 5:00PM - 7:00PM Pathways to NASH, Fibrosis and Hepatocullular Carcinoma This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 5 of 5 Maria E. Moreno-Fernandez, Cincinnati Children's Hospital, USA Short Talk: Role of the IL-17 Axis in the Progression of Non-Alcoholic Fatty Liver Disease
Tuesday, March 24 \| 7:00PM - 7:00PM On Own for Dinner
Wednesday, March 25 \| 7:00AM - 8:00AM Breakfast Room: Frontenac ABC
Wednesday, March 25 \| 8:00AM - 11:00AM Genetics of the Metabolic Syndrome Room: Macdonald DEF Speaker 1 of 5 * David Rand, Brown University, USA
Wednesday, March 25 \| 8:00AM - 11:00AM Genetics of the Metabolic Syndrome Room: Macdonald DEF Speaker 2 of 5 Norbert Perrimon, Harvard Medical School, USA Discovery of in vivo Regulators of Glucagon-Induced Hyperglycemia
Wednesday, March 25 \| 8:00AM - 11:00AM Genetics of the Metabolic Syndrome Room: Macdonald DEF Speaker 3 of 5 Jose Antonio Enríquez, Centro Nacional de Investigaciones, Spain Talk Title to be Announced
Wednesday, March 25 \| 8:00AM - 11:00AM Genetics of the Metabolic Syndrome Room: Macdonald DEF Speaker 4 of 5 Chris Day, Newcastle University, UK Genetic of NAFLD
Wednesday, March 25 \| 8:00AM - 11:00AM Genetics of the Metabolic Syndrome Room: Macdonald DEF Speaker 5 of 5 Sadaf Farooqi, University of Cambridge, UK Genetic Basis of Severe Obesity
Wednesday, March 25 \| 8:00AM - 11:00AM Extra-Hepatic Regulation of Liver Metabolism This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 1 of 6 * Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Wednesday, March 25 \| 8:00AM - 11:00AM Extra-Hepatic Regulation of Liver Metabolism This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 2 of 6 Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany Role of Distinct Ceramide Species in Obesity-Associated Insulin Resistance
Wednesday, March 25 \| 8:00AM - 11:00AM Extra-Hepatic Regulation of Liver Metabolism This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 3 of 6 Frank J. Gonzalez, National Institutes of Health, USA The Gut Microbiota Influences NAFLD thorough Intestinal FXR Signaling
Wednesday, March 25 \| 8:00AM - 11:00AM Extra-Hepatic Regulation of Liver Metabolism This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 4 of 6 George N. Ioannou, University of Washington, USA Role of Cholesterol in the Progression of Steatosis to NASH
Wednesday, March 25 \| 8:00AM - 11:00AM Extra-Hepatic Regulation of Liver Metabolism This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 5 of 6 Steven A. Kliewer, University of Texas Southwestern Medical Center, USA Metabolic FGFs 15/19 and 21: From Physiology to Pharmacology
Wednesday, March 25 \| 8:00AM - 11:00AM Extra-Hepatic Regulation of Liver Metabolism This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 6 of 6 Mattias Bergentall, Gothenburg University, Sweden Short Talk: The Gut Microbiota Modulates Sucrose-Induced NAFLD
Wednesday, March 25 \| 9:20AM - 9:40AM Coffee Break Room: Macdonald Foyer
Wednesday, March 25 \| 11:00AM - 1:00PM Poster Setup Room: Frontenac ABC
Wednesday, March 25 \| 11:00AM - 2:30PM On Own for Lunch
Wednesday, March 25 \| 1:00PM - 10:00PM Poster Viewing Room: Frontenac ABC
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: Disease Mechanism and Therapy Room: Macdonald DEF Speaker 1 of 8 * Junichiro Sonoda, Regeneron Pharmaceuticals, Inc., USA
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: Disease Mechanism and Therapy Room: Macdonald DEF Speaker 2 of 8 Laurent Mouchiroud, École Polytechnique Federale de Lausanne – EPFL, Switzerland Urolithin A Improves Fitness and Lifespan through Mitophagy
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: Disease Mechanism and Therapy Room: Macdonald DEF Speaker 3 of 8 Elizabeth K. Speliotes, University of Michigan, USA Human Genetic Variants In or Near Mitochondrial Genes Uncouple Obesity from Metabolic Disease
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: Disease Mechanism and Therapy Room: Macdonald DEF Speaker 4 of 8 Kevin G. Becker, NIA, National Institutes of Health, USA The Effects of Tomatidine on Three Cell Models of Differentiation
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: Disease Mechanism and Therapy Room: Macdonald DEF Speaker 5 of 8 Andrea Galmozzi, The Scripps Research Institute, USA ThermoMouse: An in vivo Model to Identify Modulators of UCP1 Expression in Brown Adipose Tissue
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: Disease Mechanism and Therapy Room: Macdonald DEF Speaker 6 of 8 Ambar Grijalva, Columbia University, USA Lipid Accumulation in Adipose Tissue Macrophages Reveals a Non-Classical Regulated Pathway of Lipid Release in Adipocytes
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: Disease Mechanism and Therapy Room: Macdonald DEF Speaker 7 of 8 Stefan G. Kauschke, Boehringer Ingelheim Pharma, Germany Evaluation of BACE2 Inhibitors to Delay Progression of beta-Cell Failure in T2DM
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: Disease Mechanism and Therapy Room: Macdonald DEF Speaker 8 of 8 Yael Kuperman, Weizmann Institute, Israel CRFR1 Inhibits AgRP Neurons to Allow Appropriate Sympathetic Nervous System Activity following Challenge
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: NAFLD Therapeutics This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 1 of 9 * Henry N. Ginsberg, Columbia University College of Physicians and Surgeons, USA
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: NAFLD Therapeutics This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 2 of 9 Michael L. Chouinard, Eli Lilly and Company, USA Established Therapies for Diabetes and Dyslipidemia Aimed at CYP7A1 Induction Are Vulnerable to FXR Modulation by Nutrient Fat, Perhaps Limiting their Use in Non-alcoholic Steatohepatitis (NASH)
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: NAFLD Therapeutics This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 3 of 9 Derek M. Erion, Takeda, USA DGAT2 Inhibition Prevents NAFLD and Fibrosis in the STAM Mouse Model of NASH
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: NAFLD Therapeutics This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 4 of 9 Tadasuke Komori, Wakayama Medical University, Japan The Roles of Oncostatin M in the Treatment of Nonalcoholic Fatty Liver Disease in Mice
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: NAFLD Therapeutics This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 5 of 9 Xiaoxin Wang, University of Colorado Denver, USA Treatment with the FXR-TGR5 Dual Agonist INT-767 Decreases NAFLD-NASH in Mice Fed a Western Diet
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: NAFLD Therapeutics This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 6 of 9 Eyal Breitbart, VBL Therapeutics, Israel TLR4 Complex Antagonist Inhibits Non-Alcoholic Steatohepatitis (NASH) and Liver Fibrosis
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: NAFLD Therapeutics This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 7 of 9 Narayanan Hariharan, Tekmira Pharmaceuticals, Canada Novel RNAi-Lipid Nanoparticle Therapeutics for Hypertriglyceridemia
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: NAFLD Therapeutics This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 8 of 9 Moshe Levi, Georgetown University, USA Bile Acid Sequestrant Prevents NAFLD/NASH in Diet-Induced Obesity and Insulin Resistant Mice
Wednesday, March 25 \| 2:30PM - 4:30PM Workshop 2: NAFLD Therapeutics This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 9 of 9 Mukul R. Jain, Zydus Research Centre, India Efficacy of Saroglitazar, a Novel PPAR alpha/gamma Agonist in a Mouse Model of Non-Alcoholic Steatohepatitis
Wednesday, March 25 \| 4:30PM - 5:00PM Coffee Available Room: Macdonald Foyer
Wednesday, March 25 \| 5:00PM - 7:00PM Therapy of the Metabolic Syndrome Room: Macdonald DEF Speaker 1 of 5 * Ajay Chawla, Merck Research Labs, USA
Wednesday, March 25 \| 5:00PM - 7:00PM Therapy of the Metabolic Syndrome Room: Macdonald DEF Speaker 2 of 5 Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany Novel Poly-Pharmacy for the Treatment of Obesity and Diabetes
Wednesday, March 25 \| 5:00PM - 7:00PM Therapy of the Metabolic Syndrome Room: Macdonald DEF Speaker 3 of 5 Patrick R. Griffin, The Scripps Research Institute, USA Pharmacological Repression of PPARG Improves Metabolic Parameters and Promotes Osteogenesis
Wednesday, March 25 \| 5:00PM - 7:00PM Therapy of the Metabolic Syndrome Room: Macdonald DEF Speaker 4 of 5 Saswata Talukdar, Merck Sharp & Dohme, USA Chronic Administration of a Long-Acting FGF21 Molecule PF-05231023 Decreases Body Weight and Improves Metabolic Profile in Non-Human Primates and Subjects with Type 2 Diabetes
Wednesday, March 25 \| 5:00PM - 7:00PM Therapy of the Metabolic Syndrome Room: Macdonald DEF Speaker 5 of 5 Riekelt H. Houtkooper, Academic Medical Center, Netherlands Short Talk: Tetracycline-Dependent Mitochondrial Dysfunction Confounds Research and Poses an Environmental Hazard
Wednesday, March 25 \| 5:00PM - 7:00PM Regulatory Nodes of Hepatic Energy Metabolism This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 1 of 5 * Douglas G. Mashek, University of Minnesota, USA
Wednesday, March 25 \| 5:00PM - 7:00PM Regulatory Nodes of Hepatic Energy Metabolism This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 2 of 5 Reuben J. Shaw, The Salk Institute for Biological Studies, USA AMPK: Central Integrator of Metabolic Adaptation and Mitochondrial Homeostasis
Wednesday, March 25 \| 5:00PM - 7:00PM Regulatory Nodes of Hepatic Energy Metabolism This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 3 of 5 Anders M. Näär, University of California, Berkeley, USA
Wednesday, March 25 \| 5:00PM - 7:00PM Regulatory Nodes of Hepatic Energy Metabolism This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 4 of 5 Peter A. Crawford, University of Minnesota, USA Ketone Metabolism and Hepatic Energy Homeostasis in the Absorptive State
Wednesday, March 25 \| 5:00PM - 7:00PM Regulatory Nodes of Hepatic Energy Metabolism This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 5 of 5 Geula Hanin, Hebrew University, Israel Short Talk: MicroRNA-132 Is a Reversible Amplifier of Hepatic Lipid Accumulation
Wednesday, March 25 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Frontenac ABC No registration fees are used to fund alcohol served at this function.
Wednesday, March 25 \| 7:30PM - 10:00PM Poster Session 3 Room: Frontenac ABC
Thursday, March 26 \| 7:00AM - 8:00AM Breakfast Room: Frontenac ABC
Thursday, March 26 \| 8:00AM - 11:00AM Metabolic Inflammation, Mitochondria and Metabolic Disease Room: Macdonald DEF Speaker 1 of 6 * Juleen R. Zierath, Karolinska Institutet, Sweden
Thursday, March 26 \| 8:00AM - 11:00AM Metabolic Inflammation, Mitochondria and Metabolic Disease Room: Macdonald DEF Speaker 2 of 6 Ajay Chawla, Merck Research Labs, USA Innate Control of Metabolism
Thursday, March 26 \| 8:00AM - 11:00AM Metabolic Inflammation, Mitochondria and Metabolic Disease Room: Macdonald DEF Speaker 3 of 6 Takashi Kadowaki, University of Tokyo, Japan Adiponectin Receptor and Metabolic Syndrome: Pathophysiology and Therapeutic Strategy
Thursday, March 26 \| 8:00AM - 11:00AM Metabolic Inflammation, Mitochondria and Metabolic Disease Room: Macdonald DEF Speaker 4 of 6 Anthony W. Ferrante, Columbia University, USA Immune Regulation of Systemic Metabolism
Thursday, March 26 \| 8:00AM - 11:00AM Metabolic Inflammation, Mitochondria and Metabolic Disease Room: Macdonald DEF Speaker 5 of 6 Keir J. Menzies, University of Ottawa, Canada Short Talk: NAD+ Repletion Improves the Mdx Mouse Muscle Phenotype by Countering Increased Levels of PARylation
Thursday, March 26 \| 8:00AM - 11:00AM Metabolic Inflammation, Mitochondria and Metabolic Disease Room: Macdonald DEF Speaker 6 of 6 Rudolf J. Wiesner, University of Cologne, Germany Short Talk: Inhibition of Mitochondrial Complex I by Metformin Induces a Futile Lactate Cycle, which Increases Energy Expenditure and Slows Down Development of Type 2 Diabetes (T2DM)
Thursday, March 26 \| 8:00AM - 11:00AM TAG Synthesis and Turnover This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 1 of 6 * Brian N. Finck, Washington University School of Medicine, USA
Thursday, March 26 \| 8:00AM - 11:00AM TAG Synthesis and Turnover This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 2 of 6 Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA Hepatic Lipid Synthesis and Insulin Resistance
Thursday, March 26 \| 8:00AM - 11:00AM TAG Synthesis and Turnover This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 3 of 6 Douglas G. Mashek, University of Minnesota, USA TAG Hydrolysis as a Branch Point in Hepatic Metabolism
Thursday, March 26 \| 8:00AM - 11:00AM TAG Synthesis and Turnover This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 4 of 6 Robert V. Farese Jr., Harvard School of Public Health, USA Mechanisms and Consequences of Lipid Storage
Thursday, March 26 \| 8:00AM - 11:00AM TAG Synthesis and Turnover This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 5 of 6 Elizabeth J. Parks, University of Missouri, USA In vivo Quantitation of Intracellular TAG Assembly in Humans
Thursday, March 26 \| 8:00AM - 11:00AM TAG Synthesis and Turnover This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 6 of 6 Ryan J. Schulze, Mayo Clinic, USA Short Talk: Small GTPases as Regulators of Hepatocellular Lipophagy
Thursday, March 26 \| 9:20AM - 9:40AM Coffee Break Room: Macdonald Foyer
Thursday, March 26 \| 11:00AM - 5:00PM On Own for Lunch
Thursday, March 26 \| 4:30PM - 5:00PM Coffee Available Room: Macdonald Foyer
Thursday, March 26 \| 5:00PM - 6:45PM Metabolic Syndrome and Muscle Energy Homeostasis Room: Macdonald DEF Speaker 1 of 4 * David D. Moore, Baylor College of Medicine, USA
Thursday, March 26 \| 5:00PM - 6:45PM Metabolic Syndrome and Muscle Energy Homeostasis Room: Macdonald DEF Speaker 2 of 4 Julie St-Pierre, McGill University, Canada Modulation of Mitochondrial Metabolism and Cellular Bioenergetics
Thursday, March 26 \| 5:00PM - 6:45PM Metabolic Syndrome and Muscle Energy Homeostasis Room: Macdonald DEF Speaker 3 of 4 Juleen R. Zierath, Karolinska Institutet, Sweden Altered DNA Methylation of Glycolytic and Lipogenic Genes in Skeletal Muscle and Liver from Obese and Type 2 Diabetic Patients
Thursday, March 26 \| 5:00PM - 6:45PM Metabolic Syndrome and Muscle Energy Homeostasis Room: Macdonald DEF Speaker 4 of 4 Satchidananda Panda, The Salk Institute for Biological Studies, USA Eating Pattern and Metabolic Diseases
Thursday, March 26 \| 5:00PM - 6:45PM Hepatic Metabolic Alterations Associated with NAFLD This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 1 of 4 * Jay D. Horton, University of Texas Southwestern Medical Center, USA
Thursday, March 26 \| 5:00PM - 6:45PM Hepatic Metabolic Alterations Associated with NAFLD This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 2 of 4 Jay D. Horton, University of Texas Southwestern Medical Center, USA Molecular Mediators of Nonalcoholic Fatty Liver Disease
Thursday, March 26 \| 5:00PM - 6:45PM Hepatic Metabolic Alterations Associated with NAFLD This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 3 of 4 Mark A. Herman, Duke University Medical Center, USA ChREBP Isoforms Link Glucose and Lipid Metabolism
Thursday, March 26 \| 5:00PM - 6:45PM Hepatic Metabolic Alterations Associated with NAFLD This session is from Liver Metabolism & NAFLD Room: Macdonald ABC Speaker 4 of 4 Henry N. Ginsberg, Columbia University College of Physicians and Surgeons, USA Role of Autophagy in Hepatic Lipid Homeostasis
Thursday, March 26 \| 6:45PM - 7:00PM Meeting Wrap Up: Outcomes and Future Directions (Organizers) Room: Macdonald ABCDEF
Thursday, March 26 \| 6:45PM - 7:00PM Meeting Wrap Up: Outcomes and Future Directions (Organizers) This session is from Liver Metabolism & NAFLD Room: Macdonald ABCDEF
Thursday, March 26 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Frontenac ABC No registration fees are used to fund alcohol served at this function.
Thursday, March 26 \| 8:00PM - 11:00PM Entertainment Room: Frontenac ABC Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, March 26 \| 8:00PM - 11:00PM Cash Bar Room: Frontenac ABC
Friday, March 27 \| 10:25AM - 10:25AM Departure *Session Chair.