Web Desc
Drug Discovery for Parasitic Diseases
Organizer(s): Leann M. Tilley, Philip J. Rosenthal and Kelly Chibale
Date: January 24 - 28, 2016
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by the Directors' Fund
Summary of Meeting:
Parasitic organisms, including protozoa and helminths, are among the most significant human pathogens, causing billions of infections and millions of deaths each year. For many parasitic diseases, available therapies are unsatisfactory and increasingly threatened by drug resistance. New therapies, ideally directed against novel targets, are urgently needed. Recent advances in anti-parasitic drug discovery have come from three different approaches – target-based methods that build on improved understanding of parasite biology; phenotypic high-throughput screens that are benefitting from improved technology; and repositioning and repurposing drugs developed for other indications. These different approaches all benefit from the integration of medicinal chemistry with parasitology and pharmacotherapy programs. This conference will showcase cutting-edge anti-parasitic drug discovery programs that illustrate the path from parasite biology to lead identification and from optimization to candidate selection. It will emphasize the need for coordinated integration of programs in medicinal chemistry, parasite biology, pharmacokinetics and safety assessment. It will feature emerging technologies such as chemical biology, chemoproteomics, chemical informatics, genomics, transcriptomics and metabolomics that are facilitating drug discovery. It will also discuss the current status of anti-parasitic drug resistance and advances in our understanding of mechanisms of resistance. The conference should be of interest to medicinal chemists, parasitologists, experts in drug discovery and development, pharmacologists and clinicians targeting the protozoa and helminths that cause serious human disease, including malaria, African and American trypanosomiasis, leishmaniasis, schistosomiasis and multiple other parasitic infections.
Scholarship Deadline: September 28 2015
Discounted Abstract Deadline: September 28 2015
Abstract Deadline: October 28 2015
Discounted Registration Deadline: November 23 2015
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Anacor Pharmaceuticals, Inc.

GlaxoSmithKline
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI122397-01
Funding for this conference was made possible (in part) by 1 R13 AI 122397 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 24 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function


Sunday, January 24 | 6:00PM - 8:00PM
Welcome Mixer
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Sunday, January 24 | 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall


Monday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, January 25 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Mountain/Lake

Speaker 1 of 2
* Leann M. Tilley, University of Melbourne, Australia

Monday, January 25 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Mountain/Lake

Speaker 2 of 2
Elizabeth A. Winzeler, University of California, San Diego, USA
Antimalarial Drug Discovery: From Phenotypic Screen to Novel Hits to Target Identification to Preclinical Studies

Monday, January 25 | 9:00AM - 11:15AM
Clinical Development and Evaluation
Room: Mountain/Lake

Speaker 1 of 6
* R. Kip Guy, St. Jude Children's Research Hospital, USA

Monday, January 25 | 9:00AM - 11:15AM
Clinical Development and Evaluation
Room: Mountain/Lake

Speaker 2 of 6
* Lawrence R. Dick, USA

Monday, January 25 | 9:00AM - 11:15AM
Clinical Development and Evaluation
Room: Mountain/Lake

Speaker 3 of 6
Annette Kuesel, World Health Organization, Switzerland
Clinical Development of Drugs for Control and Elimination of Helminthic Diseases

Monday, January 25 | 9:00AM - 11:15AM
Clinical Development and Evaluation
Room: Mountain/Lake

Speaker 4 of 6
Philip J. Rosenthal, University of California, San Francisco, USA
Changing Malaria Treatment Efficacy with Changes in Treatment Practices and Drug Sensitivities in Uganda

Monday, January 25 | 9:00AM - 11:15AM
Clinical Development and Evaluation
Room: Mountain/Lake

Speaker 5 of 6
Shyam Sundar, Banaras Hindu University, India
Clinical Trials for the Treatment of Visceral Leishmaniasis

Monday, January 25 | 9:00AM - 11:15AM
Clinical Development and Evaluation
Room: Mountain/Lake

Speaker 6 of 6
Ian H. Gilbert, University of Dundee, UK
Short Talk: A Fully Integrated Partnership Performing Drug Discovery towards Visceral Leishmaniasis

Monday, January 25 | 9:40AM - 10:00AM
Coffee Break
Room: Pre Function


Monday, January 25 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Monday, January 25 | 11:15AM - 5:00PM
On Own for Lunch


Monday, January 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, January 25 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, January 25 | 5:00PM - 6:40PM
Target-Based Screening
Room: Mountain/Lake

Speaker 1 of 5
* Rob Leurs, Vrije Universiteit Amsterdam, Netherlands

Monday, January 25 | 5:00PM - 6:40PM
Target-Based Screening
Room: Mountain/Lake

Speaker 2 of 5
* Tanya Paquet, University of Cape Town, South Africa

Monday, January 25 | 5:00PM - 6:40PM
Target-Based Screening
Room: Mountain/Lake

Speaker 3 of 5
James H. McKerrow, University of California, San Diego, USA
Target-Based Drug Discovery: Targeting Cysteine Proteases in Multiple Organisms

Monday, January 25 | 5:00PM - 6:40PM
Target-Based Screening
Room: Mountain/Lake

Speaker 4 of 5
Matthew S. Bogyo, Stanford University School of Medicine, USA
Structure and Function-Based Design of Plasmodium-Selective Proteasome Inhibitors

Monday, January 25 | 5:00PM - 6:40PM
Target-Based Screening
Room: Mountain/Lake

Speaker 5 of 5
Meg Phillips, University of Texas Southwestern Medical Center, USA
A Clinical Candidate Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 1 of 14
* Christopher Dean Goodman, University of Melbourne, Australia

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 2 of 14
* Philip J. Rosenthal, University of California, San Francisco, USA

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 3 of 14
Sneha Anand, Jawahar Lal Nehru University, India
Characterization of Essential Non-Translational Function of Leishmania Tyrosyl tRNA Synthetase and its Prospect as a Drug Target

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 4 of 14
Ximena Barros-Alvarez, University of Washington, USA
Structural Biology in the Development of Inhibitors Targeting Methionyl-tRNA Synthetase for the Discovery of New Therapeutics to Treat Sleeping Sickness

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 5 of 14
Jessica L. Bridgford, University of Melbourne, Australia
Targeting Artemisinin Resistance in the Malaria Parasite Plasmodium falciparum

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 6 of 14
Lynn Dong Blake, Central Michigan University College of Medicine, USA
Characterization of Menoctone Efficacy Against Plasmodium Berghei and P. falciparum

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 7 of 14
Brian R. Blank, University of California, San Francisco, USA
In Vitro and in vivo Investigation of Regioisomeric Forms of Arterolane-Like Endoperoxides

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 8 of 14
Stephanie Braillard, Drugs for Neglected Diseases Initiative, Switzerland
DNDI-0690: A New Promising Drug Candidate for the Treatment of Visceral Leishmaniasis

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 9 of 14
Angela Kelly Carrillo Alocen, St Jude Children's Research Hospital, USA
Towards the Determination of the Mechanism of Action of the Chloronitrobenzamides against Trypanosoma brucei brucei

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 10 of 14
Victoria Catherine Corey, University of California, San Diego, USA
Comprehensive Analysis of Resistance Development in the Malaria Parasite

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 11 of 14
Manu De Rycker, University of Dundee, UK
Tailored Hit-Discovery Cascades for Leishmania donovani and Trypanosoma cruzi that Combine High-Throughput Screening with Multiple Secondary Assays to Build Confidence in Hits

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 12 of 14
Gregory Goldgof, University of California, San Diego, USA
Synthetic Drug Sensitive Yeast as a Tool for Drug Target Discovery

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 13 of 14
Rob Leurs, Vrije Universiteit Amsterdam, Netherlands
Phenotypic Screening Identifies Human PDE4 Inhibitors with Submicromolar Activity Against Trypanosoma Cruzi, the Causative Agent of Chagas Disease

Monday, January 25 | 6:40PM - 7:00PM
Black Diamonds (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 14 of 14
Ebere Sonoiki, University of California, San Francisco, USA
Two Novel p. Falciparum Targets Identified by Different Benzoxaboroles

Monday, January 25 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, January 25 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay


Monday, January 25 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Tuesday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, January 26 | 8:00AM - 11:15AM
Phenotypic Screening, Repurposing and Repositioning
Room: Mountain/Lake

Speaker 1 of 8
* Jane Kelly, Portland State University, USA

Tuesday, January 26 | 8:00AM - 11:15AM
Phenotypic Screening, Repurposing and Repositioning
Room: Mountain/Lake

Speaker 2 of 8
* Leslie Street, University of Cape Town, South Africa

Tuesday, January 26 | 8:00AM - 11:15AM
Phenotypic Screening, Repurposing and Repositioning
Room: Mountain/Lake

Speaker 3 of 8
Jeremy N. Burrows, Medicines for Malaria Venture, Switzerland
Drug Discovery to Control and Eradicate Malaria

Tuesday, January 26 | 8:00AM - 11:15AM
Phenotypic Screening, Repurposing and Repositioning
Room: Mountain/Lake

Speaker 4 of 8
Michael H. Gelb, University of Washington, USA
A Phenotypic Approach to Drug Discovery for Stage II Human African trypanosomiasis

Tuesday, January 26 | 8:00AM - 11:15AM
Phenotypic Screening, Repurposing and Repositioning
Room: Mountain/Lake

Speaker 5 of 8
Jennifer Keiser, Swiss Tropical and Public Health Institute, Switzerland
Repurposing for Antischistosomal Drug Discovery: From Bench to Field

Tuesday, January 26 | 8:00AM - 11:15AM
Phenotypic Screening, Repurposing and Repositioning
Room: Mountain/Lake

Speaker 6 of 8
John Haselden, GlaxoSmithKline, Spain
Antiparasitic Hits from Phenotypic High Throughput Screening

Tuesday, January 26 | 8:00AM - 11:15AM
Phenotypic Screening, Repurposing and Repositioning
Room: Mountain/Lake

Speaker 7 of 8
Amy K. Wernimont, National Institutes of Health, USA
Short Talk: Collaborative Drug Discovery and Structural Genomics – Impact for Neglected Disease Research

Tuesday, January 26 | 8:00AM - 11:15AM
Phenotypic Screening, Repurposing and Repositioning
Room: Mountain/Lake

Speaker 8 of 8
Charles E. Mowbray, Drugs for Neglected Diseases Initiative, Switzerland
Short Talk: The NTD Drug Discovery Booster: A Novel Approach for Hit to Lead Chemistry

Tuesday, January 26 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, January 26 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, January 26 | 11:15AM - 2:30PM
On Own for Lunch


Tuesday, January 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, January 26 | 2:30PM - 4:30PM
Workshop and Panel: Drug Target to Clinic: The Pipeline
Room: Mountain/Lake

Speaker 1 of 9
* Kelly Chibale, University of Cape Town, South Africa

Tuesday, January 26 | 2:30PM - 4:30PM
Workshop and Panel: Drug Target to Clinic: The Pipeline
Room: Mountain/Lake

Speaker 2 of 9
Meg Phillips, University of Texas Southwestern Medical Center, USA
Target Validation and the Comparison of Target-Based HTS versus Whole Organism Screening

Tuesday, January 26 | 2:30PM - 4:30PM
Workshop and Panel: Drug Target to Clinic: The Pipeline
Room: Mountain/Lake

Speaker 3 of 9
Timothy G. Geary, McGill University, Canada
Moving from Concept to Reality for Repurposing an Approved Drug for a New Neglected Disease Indication

Tuesday, January 26 | 2:30PM - 4:30PM
Workshop and Panel: Drug Target to Clinic: The Pipeline
Room: Mountain/Lake

Speaker 4 of 9
Kevin Read, University of Dundee, UK
NTD Drug Discovery: An Academic Perspective

Tuesday, January 26 | 2:30PM - 4:30PM
Workshop and Panel: Drug Target to Clinic: The Pipeline
Room: Mountain/Lake

Speaker 5 of 9
Robert T. Jacobs, Anacor Pharmaceuticals, Inc., USA
Parasitic/Neglected Disease Drug Discovery: A Biotech Perspective

Tuesday, January 26 | 2:30PM - 4:30PM
Workshop and Panel: Drug Target to Clinic: The Pipeline
Room: Mountain/Lake

Speaker 6 of 9
John Haselden, GlaxoSmithKline, Spain
A Pharma Perspective on Opportunities to Transition Drug Discovery Assets into Preclinical and Early Clinical Drug Development

Tuesday, January 26 | 2:30PM - 4:30PM
Workshop and Panel: Drug Target to Clinic: The Pipeline
Room: Mountain/Lake

Speaker 7 of 9
Jeremy N. Burrows, Medicines for Malaria Venture, Switzerland
Practical Issues in Translating Antimalarial Drugs

Tuesday, January 26 | 2:30PM - 4:30PM
Workshop and Panel: Drug Target to Clinic: The Pipeline
Room: Mountain/Lake

Speaker 8 of 9
Susan A. Charman, Monash University, Australia
Human Pharmacokinetic and Dose Predictions

Tuesday, January 26 | 2:30PM - 4:30PM
Workshop and Panel: Drug Target to Clinic: The Pipeline
Room: Mountain/Lake

Speaker 9 of 9
Annette Kuesel, World Health Organization, Switzerland
What Support do Regulatory Agencies Offer

Tuesday, January 26 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, January 26 | 5:00PM - 6:40PM
Hit to Lead
Room: Mountain/Lake

Speaker 1 of 5
* Debopam Chakrabarti, University of Central Florida, USA

Tuesday, January 26 | 5:00PM - 6:40PM
Hit to Lead
Room: Mountain/Lake

Speaker 2 of 5
* Audrey R. Odom, Washington University School of Medicine, USA

Tuesday, January 26 | 5:00PM - 6:40PM
Hit to Lead
Room: Mountain/Lake

Speaker 3 of 5
Jonathan L. Vennerstrom, University of Nebraska Medical Center, USA
Discovery of Antimalarial Ozonides OZ277 and OZ439

Tuesday, January 26 | 5:00PM - 6:40PM
Hit to Lead
Room: Mountain/Lake

Speaker 4 of 5
Kelly Chibale, University of Cape Town, South Africa
Antimalarials from SoftFocus Libraries: Optimization and Target Identification

Tuesday, January 26 | 5:00PM - 6:40PM
Hit to Lead
Room: Mountain/Lake

Speaker 5 of 5
Robert T. Jacobs, Anacor Pharmaceuticals, Inc., USA
Drug Discovery and Development Based on Antiparasitic Benzoxaboroles

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 1 of 14
* Darren J. Creek, Monash University, Australia

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 2 of 14
* Leann M. Tilley, University of Melbourne, Australia

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 3 of 14
Rajiv S. Jumani, University of Vermont, USA
Methods to Prioritize Anti-Cryptosporidium Hits

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 4 of 14
Leah S. Imlay, Washington University in St. Louis, USA
Structure-Activity Relationship Studies of the Malaria Box Compound 1R,3S-MMV008138, Inhibitor of the Non-Mevalonate Pathway Enzyme IspD

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 5 of 14
Benoit Laleu, Medicines for Malaria Venture, Switzerland
The Pathogen Box Project: A Catalyst for Neglected Disease Drug Discover

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 6 of 14
Cynthia Lichorowic, Northeastern University, USA
Orally Bioavailable and In Vivo Efficacious Antimalarial 4(1H)-Quinolones

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 7 of 14
Stephan Meister, University of California, San Diego, USA
A High-Throughput Luciferase-Based Assay for the Discovery of Malaria Liver Stage Therapeutics

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 8 of 14
Jane C. Munday, University of Glasgow, UK
Functional Analysis of Parasitic PDEs Towards Validation as Potential Drug Targets

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 9 of 14
Caroline Ng, University of Nebraska Medical Center, USA
PfMDR1 Mutations Protect Against a Novel Antimalarial but Confer Sensitivity to Partner Drugs in Artemisinin-Based Combination Therapy

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 10 of 14
Ferdinand Wafula Ndubi, University of Cape Town, South Africa
Synthesis and Structure-Activity Relationship Studies of Antimalarial Pyrido [1, 2alpha] Benzimidazoles

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 11 of 14
John Okombo, University of Cape Town, South Africa
Mechanistic Profiling of Dual-Functioning Reversed Chloroquine Compounds Containing a Dibenzylmethylamine Side Chain

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 12 of 14
Khan T. Osman, University of Toronto, Canada
Discovery of Novel Dual-Kinase Inhibitors Against Parasite-Specific Protein Kinases

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 13 of 14
Sarah Preston, University of Melbourne, Australia
Working Toward New Drugs Against Parasitic Worms in Public-Private Partnership

Tuesday, January 26 | 6:40PM - 7:05PM
Short Schusses (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 14 of 14
Babu Somepalli Mastan, University of Hyderabad, India
Probing the function of Aspartyl proteases, Plasmepsin VII & VIII
in Plasmodium berghei


Tuesday, January 26 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, January 26 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay


Tuesday, January 26 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Wednesday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, January 27 | 8:00AM - 11:15AM
Drug Resistance
Room: Mountain/Lake

Speaker 1 of 7
* Elisabeth D. Martinez, University of Texas Southwestern Medical Center, USA

Wednesday, January 27 | 8:00AM - 11:15AM
Drug Resistance
Room: Mountain/Lake

Speaker 2 of 7
* Kellan C. Gregory, Collaborative Drug Discovery Inc, USA

Wednesday, January 27 | 8:00AM - 11:15AM
Drug Resistance
Room: Mountain/Lake

Speaker 3 of 7
David A. Fidock, Columbia University Medical Center, USA
Leveraging Genome Editing to Define the Genetic Basis of Antimalarial Drug Resistance

Wednesday, January 27 | 8:00AM - 11:15AM
Drug Resistance
Room: Mountain/Lake

Speaker 4 of 7
Leann M. Tilley, University of Melbourne, Australia
Molecular Basis of Artemisinin Action and Resistance

Wednesday, January 27 | 8:00AM - 11:15AM
Drug Resistance
Room: Mountain/Lake

Speaker 5 of 7
Marc Ouellette, CIHR Institute of Infection and Immunity, Canada
Functional Genomics of Drug Resistance in Leishmania

Wednesday, January 27 | 8:00AM - 11:15AM
Drug Resistance
Room: Mountain/Lake

Speaker 6 of 7
Vern B. Carruthers, University of Michigan Medical School, USA
Targeting a T. gondii Cathepsin Protease Essential for Chronic Toxoplasmosis

Wednesday, January 27 | 8:00AM - 11:15AM
Drug Resistance
Room: Mountain/Lake

Speaker 7 of 7
Kirsten Hanson, University of Texas at San Antonio, USA
Short Talk: Targeting Liver Stages of Malaria Parasites

Wednesday, January 27 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, January 27 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Wednesday, January 27 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, January 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Wednesday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, January 27 | 5:00PM - 6:40PM
Tackling Challenging Targets
Room: Mountain/Lake

Speaker 1 of 5
* Case W. McNamara, Calibr at Scripps Research, USA

Wednesday, January 27 | 5:00PM - 6:40PM
Tackling Challenging Targets
Room: Mountain/Lake

Speaker 2 of 5
* Rosa A. Maldonado, University of Texas at El Paso, USA

Wednesday, January 27 | 5:00PM - 6:40PM
Tackling Challenging Targets
Room: Mountain/Lake

Speaker 3 of 5
Timothy G. Geary, McGill University, Canada
Mechanism-Based Screening Against Nematode G Protein-Coupled Receptors: A Case History

Wednesday, January 27 | 5:00PM - 6:40PM
Tackling Challenging Targets
Room: Mountain/Lake

Speaker 4 of 5
Christophe Bodenreider, Novartis Institute for Tropical Diseases, Singapore
Development of PI(4) Kinase Inhibitors Active across the Life-Cycle of Plasmodium

Wednesday, January 27 | 5:00PM - 6:40PM
Tackling Challenging Targets
Room: Mountain/Lake

Speaker 5 of 5
Geoffrey Ian McFadden, University of Melbourne, Australia
Parasite Resistance to the Antimalarial Atovaquone is not Transmissible by Mosquitoes

Wednesday, January 27 | 6:40PM - 7:00PM
Screaming Snowboarders (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 1 of 11
* Paul Horrocks, Keele University, UK

Wednesday, January 27 | 6:40PM - 7:00PM
Screaming Snowboarders (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 2 of 11
* Kelly Chibale, University of Cape Town, South Africa

Wednesday, January 27 | 6:40PM - 7:00PM
Screaming Snowboarders (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 3 of 11
Bracken Franklin Roberts, University of Central Florida, USA
Identification of Novel Chemical Scaffolds that Inhibit All Stages of Plasmodium Asexual Life Cycle

Wednesday, January 27 | 6:40PM - 7:00PM
Screaming Snowboarders (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 4 of 11
Vijeta Sharma, Shiv Nadar University, India
Anti-Plasmodial Activity of Redox System Enzyme Inhibitor

Wednesday, January 27 | 6:40PM - 7:00PM
Screaming Snowboarders (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 5 of 11
Jair L. Siqueira-Neto, University of California, San Diego, USA
Different Strategies to Find New Active Compounds to Treat Chagas Disease

Wednesday, January 27 | 6:40PM - 7:00PM
Screaming Snowboarders (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 6 of 11
Allison Michele Stickles, Oregon Health & Science University, USA
Atovaquone and ELQ-300 Combination Therapy: A Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria

Wednesday, January 27 | 6:40PM - 7:00PM
Screaming Snowboarders (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 7 of 11
Taher Uddin, University of Melbourne, Australia
Validation of Putative Apicoplast Targeting Drugs Using a chemical Supplementation Assay in Cultured Malaria Parasites

Wednesday, January 27 | 6:40PM - 7:00PM
Screaming Snowboarders (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 8 of 11
Manu Vanaerschot, Columbia University, USA
Identifying Dihydropyridones as New Antimalarial Drug Candidates with Asexual Blood Stage and Gametocyte Activity

Wednesday, January 27 | 6:40PM - 7:00PM
Screaming Snowboarders (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 9 of 11
Richard John Wall, University of Dundee, UK
Defining Drug Mechanism of Action: Leveraging Phenotypic Hits Against Kinetoplastids

Wednesday, January 27 | 6:40PM - 7:00PM
Screaming Snowboarders (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 10 of 11
Leah Walker, Johns Hopkins School of Public Health, USA
Short Talk: Duration of Artemisinin Combination Therapy Influences Parasitological Outcome in a Mouse Model of Malaria

Wednesday, January 27 | 6:40PM - 7:00PM
Screaming Snowboarders (2 minute poster teaser talks)
Room: Mountain/Lake

Speaker 11 of 11
Clarisse Ricci, University of California, San Diego, USA
Molecular Dynamics Investigation of Plasmodium vivax GGPPS and Implications for Computer-Aided Drug Discovery

Wednesday, January 27 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Wednesday, January 27 | 7:30PM - 10:00PM
Poster Session 3
Room: Bay


Wednesday, January 27 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Thursday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, January 28 | 8:00AM - 11:15AM
Genomics, Proteomics and Metabolomics and New Technologies
Room: Mountain/Lake

Speaker 1 of 8
* Kirsten Hanson, University of Texas at San Antonio, USA

Thursday, January 28 | 8:00AM - 11:15AM
Genomics, Proteomics and Metabolomics and New Technologies
Room: Mountain/Lake

Speaker 2 of 8
* Stuart A. Ralph, University of Melbourne, Australia

Thursday, January 28 | 8:00AM - 11:15AM
Genomics, Proteomics and Metabolomics and New Technologies
Room: Mountain/Lake

Speaker 3 of 8
Sarah K. Volkman, Harvard T.H. Chan School of Public Health, USA
Genome Wide Association Studies to Gain Insights into Drug Resistance

Thursday, January 28 | 8:00AM - 11:15AM
Genomics, Proteomics and Metabolomics and New Technologies
Room: Mountain/Lake

Speaker 4 of 8
Sonja Ghidelli-Disse, Cellzome, a GSK company, Germany
Use of Chemoproteomics to Identify Parasite Targets

Thursday, January 28 | 8:00AM - 11:15AM
Genomics, Proteomics and Metabolomics and New Technologies
Room: Mountain/Lake

Speaker 5 of 8
Malcolm J. McConville, University of Melbourne, Australia
Measuring Parasite Metabolism in vivo

Thursday, January 28 | 8:00AM - 11:15AM
Genomics, Proteomics and Metabolomics and New Technologies
Room: Mountain/Lake

Speaker 6 of 8
Collette Britton, University of Glasgow, UK
Small RNAs: Association with Anthelmintic Resistance and as Potential New Drug Targets

Thursday, January 28 | 8:00AM - 11:15AM
Genomics, Proteomics and Metabolomics and New Technologies
Room: Mountain/Lake

Speaker 7 of 8
Dominique Soldati-Favre, University of Geneva, Switzerland
Short Talk: Plasmepsin IX and X: New Candidate Targets for Old Antimalarial Drugs

Thursday, January 28 | 8:00AM - 11:15AM
Genomics, Proteomics and Metabolomics and New Technologies
Room: Mountain/Lake

Speaker 8 of 8
Conor Caffrey, University of California, San Diego, USA
Short Talk: Automated Screening Technologies for Large Parasites

Thursday, January 28 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Thursday, January 28 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Thursday, January 28 | 5:00PM - 6:45PM
Pharmacokinetics and Informatics
Room: Mountain/Lake

Speaker 1 of 5
* Michael Riscoe, Oregon Health & Science University, USA

Thursday, January 28 | 5:00PM - 6:45PM
Pharmacokinetics and Informatics
Room: Mountain/Lake

Speaker 2 of 5
* Dennis E. Kyle, University of Georgia, USA

Thursday, January 28 | 5:00PM - 6:45PM
Pharmacokinetics and Informatics
Room: Mountain/Lake

Speaker 3 of 5
Kevin Read, University of Dundee, UK
Integrating Drug Metabolism and Pharmacokinetics into Antiparasitic Drug Discovery

Thursday, January 28 | 5:00PM - 6:45PM
Pharmacokinetics and Informatics
Room: Mountain/Lake

Speaker 4 of 5
Susan A. Charman, Monash University, Australia
Human Pharmacokinetic and Dose Predictions for Neglected Diseases

Thursday, January 28 | 5:00PM - 6:45PM
Pharmacokinetics and Informatics
Room: Mountain/Lake

Speaker 5 of 5
John Overington, Medicines Discovery Catapult, UK
Informatics Approaches to Target Identification and Selection for Neglected Disease Drug Discovery

Thursday, January 28 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Mountain/Lake

Speaker 1 of 1
* Philip J. Rosenthal, University of California, San Francisco, USA

Thursday, January 28 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Thursday, January 28 | 7:00PM - 8:00PM
Social Hour
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Thursday, January 28 | 8:00PM - 11:00PM
Entertainment
Room: Granhall
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 28 | 8:00PM - 11:00PM
Cash Bar
Room: Granhall


Friday, January 29 | 10:25AM - 10:25AM
Departure


*Session Chair.