Web Desc
Neurological Disorders of Intracellular Trafficking
Organizer(s): Dennis Drayna and Bettina Winckler
Date: January 31 - February 04, 2016
Location: Keystone Resort, Keystone, CO, USA
Sponsored by FORUM Pharmaceuticals Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
Deficits in intracellular trafficking are a newly emerging, unifying theme in a broad range of neurological disorders, including Alzheimer’s Disease, Huntington's Disease, Parkinson’s Disease and many others. Specific treatments for these disorders are either limited or unavailable. The meeting will look at how these trafficking deficits produce neuropathology, why these disorders are limited to the nervous system and how to elucidate trafficking networks and control points to identify novel drug targets. Specifically, it aims to: 1) Advance state-of-the-art knowledge in the cell biology of intracellular trafficking, the genetics of trafficking disorders, the clinical neurology of trafficking disorders and the methods used to identify drug targets; 2) Facilitate interactions between stakeholder groups who have traditionally had only limited contact; and 3) Identify common themes, novel approaches and new collaborations to address the many large gaps in knowledge about trafficking disorders. For the first time, the meeting will bring together groups that have traditionally not interacted, including cell biologists who study trafficking but have predominantly studied non-neural cells, clinical neurologists who do not typically work in cell biology, geneticists who have discovered causative genes for a wide range of neurological disorders but typically have limited expertise in the biological function of the gene products they identify, and drug developers, to cross-fertilize ideas and generate new collaborations.
Scholarship Deadline: September 30 2015
Discounted Abstract Deadline: September 30 2015
Abstract Deadline: November 2 2015
Discounted Registration Deadline: December 1 2015
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
FORUM Pharmaceuticals Inc.
We gratefully acknowledge additional support for this conference from:
CEDARLANEPfizer Inc.The Stuttering Foundation


The Stuttering Foundation
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
NeuroscientistNews
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS095383-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 31 | 4:00PM - 8:00PM
Arrival and Registration
Room: Keystone Lodge Lobby


Sunday, January 31 | 6:00PM - 8:00PM
Welcome Mixer
Room: Keystone Lodge-Bighorn Bar
No registration fees are used to fund alcohol served at this function.

Monday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Monday, February 01 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 1 of 2
* Dennis Drayna, NIDCD, National Institutes of Health, USA

Monday, February 01 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 2 of 2
Scott D. Emr, Cornell University, USA
Sorting Out Traffic in the Secretory and Endocytic Pathways: Yeast Genetics Points the Way

Monday, February 01 | 9:00AM - 11:00AM
Genetics: Multigenic Neurologic Disorders
Room: Grays Peak

Speaker 1 of 4
* Dennis Drayna, NIDCD, National Institutes of Health, USA

Monday, February 01 | 9:00AM - 11:00AM
Genetics: Multigenic Neurologic Disorders
Room: Grays Peak

Speaker 2 of 4
Lian Li, Emory University School of Medicine, USA
SIMPLE Mutations, Endosomal Trafficking, and Peripheral Neuropathy

Monday, February 01 | 9:00AM - 11:00AM
Genetics: Multigenic Neurologic Disorders
Room: Grays Peak

Speaker 3 of 4
Matthew J. Farrer, University of British Columbia, Canada
Genetics of Parkinson’s Disease and Other Movement Disorders

Monday, February 01 | 9:00AM - 11:00AM
Genetics: Multigenic Neurologic Disorders
Room: Grays Peak

Speaker 4 of 4
Shaoyu Lin, University of Southern California, USA
Short Talk: Haploinsufficiency for Guanine Exchange Factor Activity Leads to Neurodegeneration in C9ORF72 ALS/FTD

Monday, February 01 | 9:40AM - 10:00AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 01 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Monday, February 01 | 11:00AM - 5:00PM
On Own for Lunch


Monday, February 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Monday, February 01 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 01 | 5:00PM - 7:00PM
Genetics: Lessons from Single Genes in Neurologic Disorders
Room: Grays Peak

Speaker 1 of 5
* Craig D. Blackstone, NINDS, National Institutes of Health, USA

Monday, February 01 | 5:00PM - 7:00PM
Genetics: Lessons from Single Genes in Neurologic Disorders
Room: Grays Peak

Speaker 2 of 5
Dennis Drayna, NIDCD, National Institutes of Health, USA
Intracellular Trafficking Mutations in Persistent Stuttering

Monday, February 01 | 5:00PM - 7:00PM
Genetics: Lessons from Single Genes in Neurologic Disorders
Room: Grays Peak

Speaker 3 of 5
Rose E. Goodchild, VIB/ KU Leuven, Belgium
The DYT1 Dystonia Protein, TorsinA, Promotes Membrane Biogenesis

Monday, February 01 | 5:00PM - 7:00PM
Genetics: Lessons from Single Genes in Neurologic Disorders
Room: Grays Peak

Speaker 4 of 5
Stéphane Lefrançois, INRS, Canada
CLN5 Regulates the CLN3-Rab7 Interaction by Modulating CLN3 Conformation

Monday, February 01 | 5:00PM - 7:00PM
Genetics: Lessons from Single Genes in Neurologic Disorders
Room: Grays Peak

Speaker 5 of 5
Rachel J. Allison, Cambridge Institute for Medical Research, UK
Short Talk: Spastin Controls Lysosome Function by Promoting ER-Mediated Endosomal Tubule Fission

Monday, February 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak
No registration fees are used to fund alcohol served at this function.

Monday, February 01 | 7:30PM - 10:00PM
Poster Session 1
Room: Longs Peak


Tuesday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Tuesday, February 02 | 8:00AM - 11:30AM
The Biology of Intracellular Trafficking
Room: Grays Peak

Speaker 1 of 7
* Scott D. Emr, Cornell University, USA

Tuesday, February 02 | 8:00AM - 11:30AM
The Biology of Intracellular Trafficking
Room: Grays Peak

Speaker 2 of 7
Jennifer Hirst, University of Cambridge, UK
The AP-5 Adaptor Protein Complex and Hereditary Spastic Paraplegia


Tuesday, February 02 | 8:00AM - 11:30AM
The Biology of Intracellular Trafficking
Room: Grays Peak

Speaker 3 of 7
Mark von Zastrow, University of California, San Francisco, USA
GPCR Signaling and Endocytic Pathways

Tuesday, February 02 | 8:00AM - 11:30AM
The Biology of Intracellular Trafficking
Room: Grays Peak

Speaker 4 of 7
Phyllis I. Hanson, University of Michigan, USA
Short Talk: ESCRT-III in Endosomal Trafficking

Tuesday, February 02 | 8:00AM - 11:30AM
The Biology of Intracellular Trafficking
Room: Grays Peak

Speaker 5 of 7
Bettina Winckler, University of Virginia, USA
Neuronal Endosomes in Health and Disease

Tuesday, February 02 | 8:00AM - 11:30AM
The Biology of Intracellular Trafficking
Room: Grays Peak

Speaker 6 of 7
Rui Dong, Yale University / HHMI, USA
Short Talk: The Impact on Intracellular Trafficking of VAP, a Protein Implicated in a Familial Form of Amyotrophic Lateral Sclerosis

Tuesday, February 02 | 8:00AM - 11:30AM
The Biology of Intracellular Trafficking
Room: Grays Peak

Speaker 7 of 7
George S. Bloom, University of Virginia, USA
Short Talk: mTOR and Neuronal Cell Cycle Re-Entry: How Insulin Resistance Promotes Alzheimer’s Disease

Tuesday, February 02 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 02 | 11:30AM - 1:00PM
Poster Setup
Room: Longs Peak


Tuesday, February 02 | 11:30AM - 5:00PM
On Own for Lunch


Tuesday, February 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Tuesday, February 02 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 02 | 5:00PM - 7:15PM
Intracellular Trafficking in Neurological Diseases
Room: Grays Peak

Speaker 1 of 6
* Ellen Sidransky, NHGRI, National Institutes of Health, USA

Tuesday, February 02 | 5:00PM - 7:15PM
Intracellular Trafficking in Neurological Diseases
Room: Grays Peak

Speaker 2 of 6
Shawn Ferguson, Yale University, USA
Axonal Lysosome Transport and Maturation Defects in Alzheimer’s Disease

Tuesday, February 02 | 5:00PM - 7:15PM
Intracellular Trafficking in Neurological Diseases
Room: Grays Peak

Speaker 3 of 6
Luigi Puglielli, University of Wisconsin-Madison, USA
Increased Expression of AT-1/SLC33A1 Causes Autism by Destabilizing the Secretory Pathway

Tuesday, February 02 | 5:00PM - 7:15PM
Intracellular Trafficking in Neurological Diseases
Room: Grays Peak

Speaker 4 of 6
Rohan Teasdale, University of Queensland, Australia
Parkinson's-Associated VPS35 Mutations Alter Retromer Cellular Functions

Tuesday, February 02 | 5:00PM - 7:15PM
Intracellular Trafficking in Neurological Diseases
Room: Grays Peak

Speaker 5 of 6
Destiney Buelto, University of Michigan, USA
Short Talk: Unique Role of the Yeast ArfGAP Age2 in Clathrin-Dependent Endosomal Trafficking

Tuesday, February 02 | 5:00PM - 7:15PM
Intracellular Trafficking in Neurological Diseases
Room: Grays Peak

Speaker 6 of 6
Elin K. Esbjörner, Chalmers University of Technology, Sweden
Short Talk: Multidimensional Microscopy Approaches to Capture Protein Misfolding Reactions Related to Vesicular Trafficking Organelles and Alzheimer’s Disease

Tuesday, February 02 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Longs Peak
No registration fees are used to fund alcohol served at this function.

Tuesday, February 02 | 7:30PM - 10:00PM
Poster Session 2
Room: Longs Peak


Wednesday, February 03 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Wednesday, February 03 | 8:00AM - 11:15AM
Neurobiology of Intracellular Trafficking
Room: Grays Peak

Speaker 1 of 7
* Shawn Ferguson, Yale University, USA

Wednesday, February 03 | 8:00AM - 11:15AM
Neurobiology of Intracellular Trafficking
Room: Grays Peak

Speaker 2 of 7
Mary McCaffrey, University College Cork, Ireland
The Importance of Rab11, Rab14, the Rab11-FIPs and Endosomal Recycling in Neuronal Processes

Wednesday, February 03 | 8:00AM - 11:15AM
Neurobiology of Intracellular Trafficking
Room: Grays Peak

Speaker 3 of 7
Jose A. Esteban, Centro de Biologia Molecular Severo Ochoa, Spain
PIP3 Signaling and AMPA Receptor Trafficking During Synaptic Plasticity

Wednesday, February 03 | 8:00AM - 11:15AM
Neurobiology of Intracellular Trafficking
Room: Grays Peak

Speaker 4 of 7
Ulrich Hengst, Columbia University, USA
Regulation of Retrograde Transport in Axons through Local Synthesis of Dynein Adaptor Proteins

Wednesday, February 03 | 8:00AM - 11:15AM
Neurobiology of Intracellular Trafficking
Room: Grays Peak

Speaker 5 of 7
Tija Jacob, University of Pittsburgh School of Medicine, USA
Synaptic Tethering of alpha 5 GABA A Receptors Regulates Dendrite Outgrowth and Maturation

Wednesday, February 03 | 8:00AM - 11:15AM
Neurobiology of Intracellular Trafficking
Room: Grays Peak

Speaker 6 of 7
Adam Oaks, George Washington University, USA
Short Talk: Cc2d1a Regulates Intracellular Trafficking and Signaling in Neurons

Wednesday, February 03 | 8:00AM - 11:15AM
Neurobiology of Intracellular Trafficking
Room: Grays Peak

Speaker 7 of 7
Cameron Day, University of Utah, USA
Short Talk: Adaptation of Viral Trafficking for Arc-Mediated Synaptic Plasticity

Wednesday, February 03 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 03 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, February 03 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 03 | 5:00PM - 7:15PM
Clinical Neurology and Trafficking Disorders I
Room: Grays Peak

Speaker 1 of 5
* Ray Truant, McMaster University, Canada

Wednesday, February 03 | 5:00PM - 7:15PM
Clinical Neurology and Trafficking Disorders I
Room: Grays Peak

Speaker 2 of 5
Eric M. Morrow, Brown University, USA
Cellular Mechanisms in Christianson Syndrome, a Novel Endosomal Disorder

Wednesday, February 03 | 5:00PM - 7:15PM
Clinical Neurology and Trafficking Disorders I
Room: Grays Peak

Speaker 3 of 5
Craig D. Blackstone, NINDS, National Institutes of Health, USA
ER Shaping Proteins and Hereditary Spastic Paraplegias

Wednesday, February 03 | 5:00PM - 7:15PM
Clinical Neurology and Trafficking Disorders I
Room: Grays Peak

Speaker 4 of 5
Zbigniew K. Wszolek, Mayo Clinic College of Medicine, USA
Perry Syndrome

Wednesday, February 03 | 5:00PM - 7:15PM
Clinical Neurology and Trafficking Disorders I
Room: Grays Peak

Speaker 5 of 5
Michael D. Ehlers, Apple Tree Partners, USA
Impaired Beta-Arrestin Recruitment and Reduced Desensitization by Non-Catechol Agonism of the D1 Dopamine Receptor

Wednesday, February 03 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Longs Peak
No registration fees are used to fund alcohol served at this function.

Wednesday, February 03 | 7:30PM - 10:00PM
Poster Viewing
Room: Longs Peak


Thursday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Thursday, February 04 | 8:00AM - 11:00AM
Clinical Neurology and Trafficking Disorders II
Room: Grays Peak

Speaker 1 of 6
* Dennis Drayna, NIDCD, National Institutes of Health, USA

Thursday, February 04 | 8:00AM - 11:00AM
Clinical Neurology and Trafficking Disorders II
Room: Grays Peak

Speaker 2 of 6
Patrick A. Lewis, University of Reading, UK
Regulation of Macroautophagy by Leucine Rich Repeat Kinase 2

Thursday, February 04 | 8:00AM - 11:00AM
Clinical Neurology and Trafficking Disorders II
Room: Grays Peak

Speaker 3 of 6
Juliane Winkelmann, Helmholtz Zentrum München, Germany
Genetics of Restless Legs Syndrome and other Movement Disorders

Thursday, February 04 | 8:00AM - 11:00AM
Clinical Neurology and Trafficking Disorders II
Room: Grays Peak

Speaker 4 of 6
Ellen Sidransky, NHGRI, National Institutes of Health, USA
Parkinson's Disease and Lysosomal Storage Disorders

Thursday, February 04 | 8:00AM - 11:00AM
Clinical Neurology and Trafficking Disorders II
Room: Grays Peak

Speaker 5 of 6
Patrizia Casaccia, Advanced Science Research Center, USA
Inhibitors of Nuclear Transport as Potential Therapeutic Targets for Axonal Damage in Inflammatory Demyelination

Thursday, February 04 | 8:00AM - 11:00AM
Clinical Neurology and Trafficking Disorders II
Room: Grays Peak

Speaker 6 of 6
Kevin Luethy, KU Leuven, Belgium
Short Talk: Arf6 Blocks Synaptic Vesicle Transport to the Endosome and Suppresses Sky/TBC1D24, a Protein Mutated in Epilepsy

Thursday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 04 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 04 | 5:00PM - 6:45PM
Translational Research Opportunities in Neuronal Trafficking
Disorders

Room: Grays Peak

Speaker 1 of 4
* Tija Jacob, University of Pittsburgh School of Medicine, USA

Thursday, February 04 | 5:00PM - 6:45PM
Translational Research Opportunities in Neuronal Trafficking
Disorders

Room: Grays Peak

Speaker 2 of 4
Willem Annaert, KU Leuven, Belgium
Biological Relevance of gamma-Secretase Heterogeneity in Alzheimer’s Disease – An Alternative Avenue for Therapeutic Intervention?

Thursday, February 04 | 5:00PM - 6:45PM
Translational Research Opportunities in Neuronal Trafficking
Disorders

Room: Grays Peak

Speaker 3 of 4
Michael Lee, University of Minnesota, USA
p53-Dependent Regulation of Autophagy by c-Abl in Parkinson’s Disease

Thursday, February 04 | 5:00PM - 6:45PM
Translational Research Opportunities in Neuronal Trafficking
Disorders

Room: Grays Peak

Speaker 4 of 4
Ray Truant, McMaster University, Canada
Huntingtin Trafficking in Response to ROS and DNA Damage Leads to a Therapeutic Lead for Huntington's Disease

Thursday, February 04 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grays Peak


Thursday, February 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak
No registration fees are used to fund alcohol served at this function.

Thursday, February 04 | 8:00PM - 11:00PM
Entertainment
Room: Longs Peak
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 04 | 8:00PM - 11:00PM
Cash Bar
Room: Longs Peak


Friday, February 05 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.