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Web Desc
Neurological Disorders of Intracellular Trafficking Organizer(s): Dennis Drayna and Bettina Winckler Date: January 31 - February 04, 2016 Location: Keystone Resort, Keystone, CO, USA Sponsored by FORUM Pharmaceuticals Inc. For important information on the coronavirus, please click here Summary of Meeting: Deficits in intracellular trafficking are a newly emerging, unifying theme in a broad range of neurological disorders, including Alzheimer’s Disease, Huntington's Disease, Parkinson’s Disease and many others. Specific treatments for these disorders are either limited or unavailable. The meeting will look at how these trafficking deficits produce neuropathology, why these disorders are limited to the nervous system and how to elucidate trafficking networks and control points to identify novel drug targets. Specifically, it aims to: 1) Advance state-of-the-art knowledge in the cell biology of intracellular trafficking, the genetics of trafficking disorders, the clinical neurology of trafficking disorders and the methods used to identify drug targets; 2) Facilitate interactions between stakeholder groups who have traditionally had only limited contact; and 3) Identify common themes, novel approaches and new collaborations to address the many large gaps in knowledge about trafficking disorders. For the first time, the meeting will bring together groups that have traditionally not interacted, including cell biologists who study trafficking but have predominantly studied non-neural cells, clinical neurologists who do not typically work in cell biology, geneticists who have discovered causative genes for a wide range of neurological disorders but typically have limited expertise in the biological function of the gene products they identify, and drug developers, to cross-fertilize ideas and generate new collaborations. Scholarship Deadline: September 30 2015 Discounted Abstract Deadline: September 30 2015 Abstract Deadline: November 2 2015 Discounted Registration Deadline: December 1 2015 Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested. Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: The Stuttering Foundation We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Neurological Disorders and Stroke (NINDS) Grant No. 1R13NS095383-01 The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Neurological Disorders of Intracellular Trafficking

Organizer(s): Dennis Drayna and Bettina Winckler

Date: January 31 - February 04, 2016
Location: Keystone Resort, Keystone, CO, USA

Program


Sunday, January 31 \| 4:00PM - 8:00PM Arrival and Registration Room: Keystone Lodge Lobby
Sunday, January 31 \| 6:00PM - 8:00PM Welcome Mixer Room: Keystone Lodge-Bighorn Bar No registration fees are used to fund alcohol served at this function.
Monday, February 01 \| 7:00AM - 8:00AM Breakfast Room: Longs Peak
Monday, February 01 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Grays Peak Speaker 1 of 2 * Dennis Drayna, NIDCD, National Institutes of Health, USA
Monday, February 01 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Grays Peak Speaker 2 of 2 Scott D. Emr, Cornell University, USA Sorting Out Traffic in the Secretory and Endocytic Pathways: Yeast Genetics Points the Way
Monday, February 01 \| 9:00AM - 11:00AM Genetics: Multigenic Neurologic Disorders Room: Grays Peak Speaker 1 of 4 * Dennis Drayna, NIDCD, National Institutes of Health, USA
Monday, February 01 \| 9:00AM - 11:00AM Genetics: Multigenic Neurologic Disorders Room: Grays Peak Speaker 2 of 4 Lian Li, Emory University School of Medicine, USA SIMPLE Mutations, Endosomal Trafficking, and Peripheral Neuropathy
Monday, February 01 \| 9:00AM - 11:00AM Genetics: Multigenic Neurologic Disorders Room: Grays Peak Speaker 3 of 4 Matthew J. Farrer, University of British Columbia, Canada Genetics of Parkinson’s Disease and Other Movement Disorders
Monday, February 01 \| 9:00AM - 11:00AM Genetics: Multigenic Neurologic Disorders Room: Grays Peak Speaker 4 of 4 Shaoyu Lin, University of Southern California, USA Short Talk: Haploinsufficiency for Guanine Exchange Factor Activity Leads to Neurodegeneration in C9ORF72 ALS/FTD
Monday, February 01 \| 9:40AM - 10:00AM Coffee Break Room: Longs Peak Foyer
Monday, February 01 \| 11:00AM - 1:00PM Poster Setup Room: Longs Peak
Monday, February 01 \| 11:00AM - 5:00PM On Own for Lunch
Monday, February 01 \| 1:00PM - 10:00PM Poster Viewing Room: Longs Peak
Monday, February 01 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, February 01 \| 5:00PM - 7:00PM Genetics: Lessons from Single Genes in Neurologic Disorders Room: Grays Peak Speaker 1 of 5 * Craig D. Blackstone, NINDS, National Institutes of Health, USA
Monday, February 01 \| 5:00PM - 7:00PM Genetics: Lessons from Single Genes in Neurologic Disorders Room: Grays Peak Speaker 2 of 5 Dennis Drayna, NIDCD, National Institutes of Health, USA Intracellular Trafficking Mutations in Persistent Stuttering
Monday, February 01 \| 5:00PM - 7:00PM Genetics: Lessons from Single Genes in Neurologic Disorders Room: Grays Peak Speaker 3 of 5 Rose E. Goodchild, VIB/ KU Leuven, Belgium The DYT1 Dystonia Protein, TorsinA, Promotes Membrane Biogenesis
Monday, February 01 \| 5:00PM - 7:00PM Genetics: Lessons from Single Genes in Neurologic Disorders Room: Grays Peak Speaker 4 of 5 Stéphane Lefrançois, INRS, Canada CLN5 Regulates the CLN3-Rab7 Interaction by Modulating CLN3 Conformation
Monday, February 01 \| 5:00PM - 7:00PM Genetics: Lessons from Single Genes in Neurologic Disorders Room: Grays Peak Speaker 5 of 5 Rachel J. Allison, Cambridge Institute for Medical Research, UK Short Talk: Spastin Controls Lysosome Function by Promoting ER-Mediated Endosomal Tubule Fission
Monday, February 01 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Longs Peak No registration fees are used to fund alcohol served at this function.
Monday, February 01 \| 7:30PM - 10:00PM Poster Session 1 Room: Longs Peak
Tuesday, February 02 \| 7:00AM - 8:00AM Breakfast Room: Longs Peak
Tuesday, February 02 \| 8:00AM - 11:30AM The Biology of Intracellular Trafficking Room: Grays Peak Speaker 1 of 7 * Scott D. Emr, Cornell University, USA
Tuesday, February 02 \| 8:00AM - 11:30AM The Biology of Intracellular Trafficking Room: Grays Peak Speaker 2 of 7 Jennifer Hirst, University of Cambridge, UK The AP-5 Adaptor Protein Complex and Hereditary Spastic Paraplegia
Tuesday, February 02 \| 8:00AM - 11:30AM The Biology of Intracellular Trafficking Room: Grays Peak Speaker 3 of 7 Mark von Zastrow, University of California, San Francisco, USA GPCR Signaling and Endocytic Pathways
Tuesday, February 02 \| 8:00AM - 11:30AM The Biology of Intracellular Trafficking Room: Grays Peak Speaker 4 of 7 Phyllis I. Hanson, University of Michigan, USA Short Talk: ESCRT-III in Endosomal Trafficking
Tuesday, February 02 \| 8:00AM - 11:30AM The Biology of Intracellular Trafficking Room: Grays Peak Speaker 5 of 7 Bettina Winckler, University of Virginia, USA Neuronal Endosomes in Health and Disease
Tuesday, February 02 \| 8:00AM - 11:30AM The Biology of Intracellular Trafficking Room: Grays Peak Speaker 6 of 7 Rui Dong, Yale University / HHMI, USA Short Talk: The Impact on Intracellular Trafficking of VAP, a Protein Implicated in a Familial Form of Amyotrophic Lateral Sclerosis
Tuesday, February 02 \| 8:00AM - 11:30AM The Biology of Intracellular Trafficking Room: Grays Peak Speaker 7 of 7 George S. Bloom, University of Virginia, USA Short Talk: mTOR and Neuronal Cell Cycle Re-Entry: How Insulin Resistance Promotes Alzheimer’s Disease
Tuesday, February 02 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Tuesday, February 02 \| 11:30AM - 1:00PM Poster Setup Room: Longs Peak
Tuesday, February 02 \| 11:30AM - 5:00PM On Own for Lunch
Tuesday, February 02 \| 1:00PM - 10:00PM Poster Viewing Room: Longs Peak
Tuesday, February 02 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, February 02 \| 5:00PM - 7:15PM Intracellular Trafficking in Neurological Diseases Room: Grays Peak Speaker 1 of 6 * Ellen Sidransky, NHGRI, National Institutes of Health, USA
Tuesday, February 02 \| 5:00PM - 7:15PM Intracellular Trafficking in Neurological Diseases Room: Grays Peak Speaker 2 of 6 Shawn Ferguson, Yale University, USA Axonal Lysosome Transport and Maturation Defects in Alzheimer’s Disease
Tuesday, February 02 \| 5:00PM - 7:15PM Intracellular Trafficking in Neurological Diseases Room: Grays Peak Speaker 3 of 6 Luigi Puglielli, University of Wisconsin-Madison, USA Increased Expression of AT-1/SLC33A1 Causes Autism by Destabilizing the Secretory Pathway
Tuesday, February 02 \| 5:00PM - 7:15PM Intracellular Trafficking in Neurological Diseases Room: Grays Peak Speaker 4 of 6 Rohan Teasdale, University of Queensland, Australia Parkinson's-Associated VPS35 Mutations Alter Retromer Cellular Functions
Tuesday, February 02 \| 5:00PM - 7:15PM Intracellular Trafficking in Neurological Diseases Room: Grays Peak Speaker 5 of 6 Destiney Buelto, University of Michigan, USA Short Talk: Unique Role of the Yeast ArfGAP Age2 in Clathrin-Dependent Endosomal Trafficking
Tuesday, February 02 \| 5:00PM - 7:15PM Intracellular Trafficking in Neurological Diseases Room: Grays Peak Speaker 6 of 6 Elin K. Esbjörner, Chalmers University of Technology, Sweden Short Talk: Multidimensional Microscopy Approaches to Capture Protein Misfolding Reactions Related to Vesicular Trafficking Organelles and Alzheimer’s Disease
Tuesday, February 02 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Longs Peak No registration fees are used to fund alcohol served at this function.
Tuesday, February 02 \| 7:30PM - 10:00PM Poster Session 2 Room: Longs Peak
Wednesday, February 03 \| 7:00AM - 8:00AM Breakfast Room: Longs Peak
Wednesday, February 03 \| 8:00AM - 11:15AM Neurobiology of Intracellular Trafficking Room: Grays Peak Speaker 1 of 7 * Shawn Ferguson, Yale University, USA
Wednesday, February 03 \| 8:00AM - 11:15AM Neurobiology of Intracellular Trafficking Room: Grays Peak Speaker 2 of 7 Mary McCaffrey, University College Cork, Ireland The Importance of Rab11, Rab14, the Rab11-FIPs and Endosomal Recycling in Neuronal Processes
Wednesday, February 03 \| 8:00AM - 11:15AM Neurobiology of Intracellular Trafficking Room: Grays Peak Speaker 3 of 7 Jose A. Esteban, Centro de Biologia Molecular Severo Ochoa, Spain PIP3 Signaling and AMPA Receptor Trafficking During Synaptic Plasticity
Wednesday, February 03 \| 8:00AM - 11:15AM Neurobiology of Intracellular Trafficking Room: Grays Peak Speaker 4 of 7 Ulrich Hengst, Columbia University, USA Regulation of Retrograde Transport in Axons through Local Synthesis of Dynein Adaptor Proteins
Wednesday, February 03 \| 8:00AM - 11:15AM Neurobiology of Intracellular Trafficking Room: Grays Peak Speaker 5 of 7 Tija Jacob, University of Pittsburgh School of Medicine, USA Synaptic Tethering of alpha 5 GABA A Receptors Regulates Dendrite Outgrowth and Maturation
Wednesday, February 03 \| 8:00AM - 11:15AM Neurobiology of Intracellular Trafficking Room: Grays Peak Speaker 6 of 7 Adam Oaks, George Washington University, USA Short Talk: Cc2d1a Regulates Intracellular Trafficking and Signaling in Neurons
Wednesday, February 03 \| 8:00AM - 11:15AM Neurobiology of Intracellular Trafficking Room: Grays Peak Speaker 7 of 7 Cameron Day, University of Utah, USA Short Talk: Adaptation of Viral Trafficking for Arc-Mediated Synaptic Plasticity
Wednesday, February 03 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Wednesday, February 03 \| 11:15AM - 5:00PM On Own for Lunch
Wednesday, February 03 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, February 03 \| 5:00PM - 7:15PM Clinical Neurology and Trafficking Disorders I Room: Grays Peak Speaker 1 of 5 * Ray Truant, McMaster University, Canada
Wednesday, February 03 \| 5:00PM - 7:15PM Clinical Neurology and Trafficking Disorders I Room: Grays Peak Speaker 2 of 5 Eric M. Morrow, Brown University, USA Cellular Mechanisms in Christianson Syndrome, a Novel Endosomal Disorder
Wednesday, February 03 \| 5:00PM - 7:15PM Clinical Neurology and Trafficking Disorders I Room: Grays Peak Speaker 3 of 5 Craig D. Blackstone, NINDS, National Institutes of Health, USA ER Shaping Proteins and Hereditary Spastic Paraplegias
Wednesday, February 03 \| 5:00PM - 7:15PM Clinical Neurology and Trafficking Disorders I Room: Grays Peak Speaker 4 of 5 Zbigniew K. Wszolek, Mayo Clinic College of Medicine, USA Perry Syndrome
Wednesday, February 03 \| 5:00PM - 7:15PM Clinical Neurology and Trafficking Disorders I Room: Grays Peak Speaker 5 of 5 Michael D. Ehlers, Apple Tree Partners, USA Impaired Beta-Arrestin Recruitment and Reduced Desensitization by Non-Catechol Agonism of the D1 Dopamine Receptor
Wednesday, February 03 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Longs Peak No registration fees are used to fund alcohol served at this function.
Wednesday, February 03 \| 7:30PM - 10:00PM Poster Viewing Room: Longs Peak
Thursday, February 04 \| 7:00AM - 8:00AM Breakfast Room: Longs Peak
Thursday, February 04 \| 8:00AM - 11:00AM Clinical Neurology and Trafficking Disorders II Room: Grays Peak Speaker 1 of 6 * Dennis Drayna, NIDCD, National Institutes of Health, USA
Thursday, February 04 \| 8:00AM - 11:00AM Clinical Neurology and Trafficking Disorders II Room: Grays Peak Speaker 2 of 6 Patrick A. Lewis, University of Reading, UK Regulation of Macroautophagy by Leucine Rich Repeat Kinase 2
Thursday, February 04 \| 8:00AM - 11:00AM Clinical Neurology and Trafficking Disorders II Room: Grays Peak Speaker 3 of 6 Juliane Winkelmann, Helmholtz Zentrum München, Germany Genetics of Restless Legs Syndrome and other Movement Disorders
Thursday, February 04 \| 8:00AM - 11:00AM Clinical Neurology and Trafficking Disorders II Room: Grays Peak Speaker 4 of 6 Ellen Sidransky, NHGRI, National Institutes of Health, USA Parkinson's Disease and Lysosomal Storage Disorders
Thursday, February 04 \| 8:00AM - 11:00AM Clinical Neurology and Trafficking Disorders II Room: Grays Peak Speaker 5 of 6 Patrizia Casaccia, Advanced Science Research Center, USA Inhibitors of Nuclear Transport as Potential Therapeutic Targets for Axonal Damage in Inflammatory Demyelination
Thursday, February 04 \| 8:00AM - 11:00AM Clinical Neurology and Trafficking Disorders II Room: Grays Peak Speaker 6 of 6 Kevin Luethy, KU Leuven, Belgium Short Talk: Arf6 Blocks Synaptic Vesicle Transport to the Endosome and Suppresses Sky/TBC1D24, a Protein Mutated in Epilepsy
Thursday, February 04 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Thursday, February 04 \| 11:00AM - 5:00PM On Own for Lunch
Thursday, February 04 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, February 04 \| 5:00PM - 6:45PM Translational Research Opportunities in Neuronal Trafficking Disorders Room: Grays Peak Speaker 1 of 4 * Tija Jacob, University of Pittsburgh School of Medicine, USA
Thursday, February 04 \| 5:00PM - 6:45PM Translational Research Opportunities in Neuronal Trafficking Disorders Room: Grays Peak Speaker 2 of 4 Willem Annaert, KU Leuven, Belgium Biological Relevance of gamma-Secretase Heterogeneity in Alzheimer’s Disease – An Alternative Avenue for Therapeutic Intervention?
Thursday, February 04 \| 5:00PM - 6:45PM Translational Research Opportunities in Neuronal Trafficking Disorders Room: Grays Peak Speaker 3 of 4 Michael Lee, University of Minnesota, USA p53-Dependent Regulation of Autophagy by c-Abl in Parkinson’s Disease
Thursday, February 04 \| 5:00PM - 6:45PM Translational Research Opportunities in Neuronal Trafficking Disorders Room: Grays Peak Speaker 4 of 4 Ray Truant, McMaster University, Canada Huntingtin Trafficking in Response to ROS and DNA Damage Leads to a Therapeutic Lead for Huntington's Disease
Thursday, February 04 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Grays Peak
Thursday, February 04 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Longs Peak No registration fees are used to fund alcohol served at this function.
Thursday, February 04 \| 8:00PM - 11:00PM Entertainment Room: Longs Peak Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, February 04 \| 8:00PM - 11:00PM Cash Bar Room: Longs Peak
Friday, February 05 \| 10:23AM - 10:23AM Departure *Session Chair †Invited, not yet responded.