Web Desc
Obesity and Adipose Tissue Biology
Organizer(s): Yu-Hua Tseng, Philipp E. Scherer and Deborah Clegg
Date: February 15 - 19, 2016
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by MedImmune and Novo Nordisk A/S
Summary of Meeting:
Obesity is a growing pandemic and a major contributor to metabolic syndrome and disorders such as type 2 diabetes, cardiovascular disease, dyslipidemia, non-alcohol fatty liver and some cancers. Excess fat mass is the main characteristic of obesity, and adipocytes are the critical players in obesity-associated metabolic disorders. This symposium will focus on recent advances in our understanding of adipocyte biology and its related pathogenesis. These scientific breakthroughs include fundamental aspects of adipocyte development, heterogeneity of fat cells and their progenitors, fuel utilization in different types of adipocytes, environmental imprinting of adipose tissue, adipose tissue remodeling, brain-adipose communication and non-adipose tissue adipocytes. This meeting aims to unite interdisciplinary researchers, from basic and translational scientists to clinicians and industrial scientists, in order to integrate and synergize the diverse body of knowledge of adipose tissue, discuss cutting-edge technologies and foster collaborative interactions. Attendees will gain an in-depth knowledge of adipocyte biology and new insight into the role of adipose tissue in obesity and its related metabolic disorders.
Scholarship Deadline: October 15 2015
Discounted Abstract Deadline: October 15 2015
Abstract Deadline: November 17 2015
Discounted Registration Deadline: December 15 2015
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
MedImmuneNovo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
Adipogen InternationalALPCO DiagnosticsEducational grant from Lilly
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Eli Lilly and Company
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK104611-01

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK104611-02
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, February 15 | 4:00PM - 8:00PM
Arrival and Registration
Room: Van Horne Foyer


Monday, February 15 | 6:00PM - 8:00PM
Welcome Mixer
Room: Van Horne Foyer
No registration fees are used to fund alcohol served at this function.

Tuesday, February 16 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne B/C


Tuesday, February 16 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Van Horne A

Speaker 1 of 1
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
New Dimensions in the Biology of Adipose Tissue and its Role in Insulin Resistance

Tuesday, February 16 | 9:00AM - 11:30AM
Brain-Adipose Communication
Room: Van Horne A

Speaker 1 of 6
* Yong Xu, Baylor College of Medicine, USA

Tuesday, February 16 | 9:00AM - 11:30AM
Brain-Adipose Communication
Room: Van Horne A

Speaker 2 of 6
Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany
Astrocytes, Microglia, and Neurons in Body Weight Regulation

Tuesday, February 16 | 9:00AM - 11:30AM
Brain-Adipose Communication
Room: Van Horne A

Speaker 3 of 6
Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
Hypothalamic Regulation of Metabolism

Tuesday, February 16 | 9:00AM - 11:30AM
Brain-Adipose Communication
Room: Van Horne A

Speaker 4 of 6
Gary J. Schwartz, Albert Einstein College of Medicine, USA
CNS and SNS Control of Adipose Function

Tuesday, February 16 | 9:00AM - 11:30AM
Brain-Adipose Communication
Room: Van Horne A

Speaker 5 of 6
Atul Chopra, Case Western Reserve University, USA
Short Talk: Asprosin, a Fasting-Induced, Glucogenic and Orexigenic, Protein Hormone

Tuesday, February 16 | 9:00AM - 11:30AM
Brain-Adipose Communication
Room: Van Horne A

Speaker 6 of 6
Ana Domingos, University of Oxford, UK
Short Talk: Lean on Body Neurons

Tuesday, February 16 | 9:40AM - 10:00AM
Coffee Break
Room: Van Horne Foyer


Tuesday, February 16 | 11:30AM - 1:00PM
Poster Setup
Room: Van Horne B/C


Tuesday, February 16 | 11:30AM - 5:00PM
On Own for Lunch


Tuesday, February 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Van Horne B/C


Tuesday, February 16 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, February 16 | 5:00PM - 7:00PM
Environmental Imprinting of Adipose Phenotype
Room: Van Horne A

Speaker 1 of 5
* Kevin L. Grove, Novo Nordisk, USA

Tuesday, February 16 | 5:00PM - 7:00PM
Environmental Imprinting of Adipose Phenotype
Room: Van Horne A

Speaker 2 of 5
Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA
Cold-Induced Dynamics in Brown, Beige and White Adipose Tissue

Tuesday, February 16 | 5:00PM - 7:00PM
Environmental Imprinting of Adipose Phenotype
Room: Van Horne A

Speaker 3 of 5
Matthias Blüher, University of Leipzig, Germany
Molecular Determinants of Adipose Tissue Health

Tuesday, February 16 | 5:00PM - 7:00PM
Environmental Imprinting of Adipose Phenotype
Room: Van Horne A

Speaker 4 of 5
Xin L. Ma, Thomas Jefferson University, USA
Novel Insight into Adiponectin Receptor Function

Tuesday, February 16 | 5:00PM - 7:00PM
Environmental Imprinting of Adipose Phenotype
Room: Van Horne A

Speaker 5 of 5
Kristen E. Boyle, University of Colorado School of Medicine, USA
Short Talk: DNA Hypermethylation of Metabolic Genes Corresponds to Lower Fatty Acid Oxidation in Mesenchymal Stem Cells from Infants of Obese Mothers: The Healthy Start BabyBUMP Project

Tuesday, February 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne B/C
No registration fees are used to fund alcohol served at this function.

Tuesday, February 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Van Horne B/C


Wednesday, February 17 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne B/C


Wednesday, February 17 | 8:00AM - 11:00AM
Developmental Origin and Recruitment of Adipose Tissue
Room: Van Horne A

Speaker 1 of 7
* Stephen R. Farmer, Boston University School of Medicine, USA

Wednesday, February 17 | 8:00AM - 11:00AM
Developmental Origin and Recruitment of Adipose Tissue
Room: Van Horne A

Speaker 2 of 7
Edward T. Chouchani, Dana-Farber Cancer Institute, USA
White, Brown and Beige Fat: Basic Biology and Novel Thermogenic Pathways

Wednesday, February 17 | 8:00AM - 11:00AM
Developmental Origin and Recruitment of Adipose Tissue
Room: Van Horne A

Speaker 3 of 7
Sheila Collins, Vanderbilt University Medical Center, USA
Integrating Signaling Mechanisms for Adipocyte 'Browning'


Wednesday, February 17 | 8:00AM - 11:00AM
Developmental Origin and Recruitment of Adipose Tissue
Room: Van Horne A

Speaker 4 of 7
Aaron M. Cypess, NIDDK, National Institutes of Health, USA
Short Talk: Mild Intermittent Cooling of Mice is Sufficient to Increase the Thermogenic Capacity of the Adipose Tissue Depots

Wednesday, February 17 | 8:00AM - 11:00AM
Developmental Origin and Recruitment of Adipose Tissue
Room: Van Horne A

Speaker 5 of 7
Rana K. Gupta, University of Texas Southwestern Medical Center, USA
Establishment and Maintenance of the White Adipose Lineage by Zfp423

Wednesday, February 17 | 8:00AM - 11:00AM
Developmental Origin and Recruitment of Adipose Tissue
Room: Van Horne A

Speaker 6 of 7
Ajay Chawla, Merck Research Labs, USA
Innate Immunity and Beige Fat Thermogenesis

Wednesday, February 17 | 8:00AM - 11:00AM
Developmental Origin and Recruitment of Adipose Tissue
Room: Van Horne A

Speaker 7 of 7
Dwight J. Klemm, University of Colorado Denver Anschutz Medical Center, USA
Short Talk: Integrin Beta1 Regulates Production of Adipocytes and Other Mesenchymal Lineages from Adipose Tissue Stromal Myeloid Cells

Wednesday, February 17 | 9:40AM - 10:00AM
Coffee Break
Room: Van Horne Foyer


Wednesday, February 17 | 11:00AM - 1:00PM
Poster Setup
Room: Van Horne B/C


Wednesday, February 17 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, February 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Van Horne B/C


Wednesday, February 17 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, February 17 | 5:00PM - 7:00PM
Cross-Talk between Adipose Tissue and Other Organs
Room: Van Horne A

Speaker 1 of 5
* Jacqueline M. Stephens, Louisiana State University, USA

Wednesday, February 17 | 5:00PM - 7:00PM
Cross-Talk between Adipose Tissue and Other Organs
Room: Van Horne A

Speaker 2 of 5
Domenico Accili, Columbia University, USA
Cross-Talk between Adipose Tissue and Pancreatic Beta Cells

Wednesday, February 17 | 5:00PM - 7:00PM
Cross-Talk between Adipose Tissue and Other Organs
Room: Van Horne A

Speaker 3 of 5
Michael P. Czech, University of Massachusetts Medical School, USA
Adipose Tissue and Hepatic Glucose Metabolism

Wednesday, February 17 | 5:00PM - 7:00PM
Cross-Talk between Adipose Tissue and Other Organs
Room: Van Horne A

Speaker 4 of 5
Anthony M. Heagerty, University of Manchester, UK
The Role of Adipose Tissue in Cardiovascular Function

Wednesday, February 17 | 5:00PM - 7:00PM
Cross-Talk between Adipose Tissue and Other Organs
Room: Van Horne A

Speaker 5 of 5
Iichiro Shimomura, Osaka University, Japan
Short Talk: Adiponectin, Fat-Derived Abundant Secretory Factor, Accumulates in Vasculature and Exhibits Vascular Protective Action, via T-Cadherin

Wednesday, February 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne B/C
No registration fees are used to fund alcohol served at this function.

Wednesday, February 17 | 7:30PM - 10:00PM
Poster Session 2
Room: Van Horne B/C


Thursday, February 18 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne B/C


Thursday, February 18 | 8:00AM - 11:15AM
Regulation of Fuel Utilization in Adipose Tissue
Room: Van Horne A

Speaker 1 of 7
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Thursday, February 18 | 8:00AM - 11:15AM
Regulation of Fuel Utilization in Adipose Tissue
Room: Van Horne A

Speaker 2 of 7
Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Lipogenesis in Adipose Tissue

Thursday, February 18 | 8:00AM - 11:15AM
Regulation of Fuel Utilization in Adipose Tissue
Room: Van Horne A

Speaker 3 of 7
Stephan Herzig, Helmholtz Zentrum München, Germany
Molecular Control of Lipid Handling in Adipocytes

Thursday, February 18 | 8:00AM - 11:15AM
Regulation of Fuel Utilization in Adipose Tissue
Room: Van Horne A

Speaker 4 of 7
Denis P. Blondin, University of Sherbrooke, Canada
Short Talk: Inhibition of Intracellular Triglyceride Lipolysis Significantly Impairs BAT Oxidative Metabolism in Humans

Thursday, February 18 | 8:00AM - 11:15AM
Regulation of Fuel Utilization in Adipose Tissue
Room: Van Horne A

Speaker 5 of 7
Chih-Hao Lee, Harvard University School of Public Health, USA
Mitochondrial Remodeling and Metabolic Flexibility

Thursday, February 18 | 8:00AM - 11:15AM
Regulation of Fuel Utilization in Adipose Tissue
Room: Van Horne A

Speaker 6 of 7
Barbara Cannon, Stockholm University, Sweden
Mitochondrial Uncoupling and Fuel Utilization

Thursday, February 18 | 8:00AM - 11:15AM
Regulation of Fuel Utilization in Adipose Tissue
Room: Van Horne A

Speaker 7 of 7
Violeta I. Gallardo Montejano, University of Texas Southwestern Medical Center, USA
Short Talk: Perilipin 5 Expression in Mouse Brown Adipose Tissue Regulates Systemic Glucose and Lipid Metabolism

Thursday, February 18 | 9:40AM - 10:00AM
Coffee Break
Room: Van Horne Foyer


Thursday, February 18 | 11:15AM - 1:00PM
Poster Setup
Room: Van Horne B/C


Thursday, February 18 | 11:15AM - 2:30PM
On Own for Lunch


Thursday, February 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Van Horne B/C


Thursday, February 18 | 2:30PM - 4:30PM
Workshop: New Therapeutic Approaches for Obesity and Related
Metabolic Disorders
Room: Van Horne A

Speaker 1 of 10
* Christopher D. Church, MedImmune, UK

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: New Therapeutic Approaches for Obesity and Related
Metabolic Disorders
Room: Van Horne A

Speaker 2 of 10
* Patrick Seale, University of Pennsylvania, USA

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: New Therapeutic Approaches for Obesity and Related
Metabolic Disorders
Room: Van Horne A

Speaker 3 of 10
Andres Andres Contreras, Michigan State University, USA
Perivascular Adipose Tissue Adipocyte Progenitor Distribution Is Influenced by Gender and Anatomical Site

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: New Therapeutic Approaches for Obesity and Related
Metabolic Disorders
Room: Van Horne A

Speaker 4 of 10
Lei Sun, Duke-NUS Graduate Medical School Singapore, Singapore
De novo Reconstruction of Adipose Tissue Transcriptomes Reveals Novel Long Noncoding RNAs that Regulate Brown Adipocyte Development

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: New Therapeutic Approaches for Obesity and Related
Metabolic Disorders
Room: Van Horne A

Speaker 5 of 10
Eric S. Muise, Merck & Co., Inc., USA
Acute Treatment of Mice with Potent AMPK Activators Mimics Acute Exercise-Induced Transcriptional Effects in White and Brown Adipose Tissues

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: New Therapeutic Approaches for Obesity and Related
Metabolic Disorders
Room: Van Horne A

Speaker 6 of 10
Cecile Vernochet, Bill & Melinda Gates Medical Research Institute, USA
Lysophospholipase-like 1 (LYPLAL1) Inhibition Impacts Adipocyte Biology and Impairs Insulin Mediated Glucose Uptake

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: New Therapeutic Approaches for Obesity and Related
Metabolic Disorders
Room: Van Horne A

Speaker 7 of 10
Christina Camell, University of Minnesota, USA
NLRP3 Inflammasome Controls Adipose Tissue Leukocytosis and Inflammation During Aging

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: New Therapeutic Approaches for Obesity and Related
Metabolic Disorders
Room: Van Horne A

Speaker 8 of 10
Mathieu Laplante, Laval University, Canada
The Pre-Adipokine EMPRD Promotes the Commitment and the Development of White Adipocytes

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: New Therapeutic Approaches for Obesity and Related
Metabolic Disorders
Room: Van Horne A

Speaker 9 of 10
Hedi Soussi, University Pierre and Marie Curie, France
DAPK2 Down-Regulation Associates with Attenuated Adipocyte Autophagic Clearance in Human Obesity

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: New Therapeutic Approaches for Obesity and Related
Metabolic Disorders
Room: Van Horne A

Speaker 10 of 10
Jin Shang, USA
Dysmetabolic Obese Rhesus Monkeys Exhibit Insulin Resistance that is Similar But Not Identical to Obese Humans

Thursday, February 18 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, February 18 | 5:00PM - 7:00PM
Non-Adipose Tissue Adipocytes
Room: Van Horne A

Speaker 1 of 6
* Victor Leonard Schuster, Albert Einstein College of Medicine, USA

Thursday, February 18 | 5:00PM - 7:00PM
Non-Adipose Tissue Adipocytes
Room: Van Horne A

Speaker 2 of 6
Clifford J. Rosen, Maine Medical Center, USA
Adipocytes in Bone

Thursday, February 18 | 5:00PM - 7:00PM
Non-Adipose Tissue Adipocytes
Room: Van Horne A

Speaker 3 of 6
Maksim Plikus, University of California, Irvine, USA
The Role of Adipocytes in Skin Biology and Regeneration

Thursday, February 18 | 5:00PM - 7:00PM
Non-Adipose Tissue Adipocytes
Room: Van Horne A

Speaker 4 of 6
Saswata Talukdar, Merck Sharp & Dohme, USA
Short Talk: FGF21 Regulates Sweet and Alcohol Preference

Thursday, February 18 | 5:00PM - 7:00PM
Non-Adipose Tissue Adipocytes
Room: Van Horne A

Speaker 5 of 6
Silvia Corvera, University of Massachusetts Medical School, USA
Short Talk: Human Brite/Beige Adipocytes Derived from Human Capillary Networks Improve Glucose Disposal in Humanized Mice

Thursday, February 18 | 5:00PM - 7:00PM
Non-Adipose Tissue Adipocytes
Room: Van Horne A

Speaker 6 of 6
Alexander Bartelt, Ludwig-Maximilians-University, Germany
Short Talk: A Central Role for Nfe2l1 in ER Adaptation and Mitochondrial Health in Brown Fat

Thursday, February 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne B/C
No registration fees are used to fund alcohol served at this function.

Thursday, February 18 | 7:30PM - 10:00PM
Poster Session 3
Room: Van Horne B/C


Friday, February 19 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne B/C


Friday, February 19 | 8:00AM - 11:15AM
Adipose Tissue Remodeling
Room: Van Horne A

Speaker 1 of 7
* Jan Nedergaard, Stockholm University, Sweden

Friday, February 19 | 8:00AM - 11:15AM
Adipose Tissue Remodeling
Room: Van Horne A

Speaker 2 of 7
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipose Tissue Fibrosis and Metabolic Dysfunction

Friday, February 19 | 8:00AM - 11:15AM
Adipose Tissue Remodeling
Room: Van Horne A

Speaker 3 of 7
Andreas Stahl, University of California, Berkeley, USA
Engineering Brown Adipose Tissue

Friday, February 19 | 8:00AM - 11:15AM
Adipose Tissue Remodeling
Room: Van Horne A

Speaker 4 of 7
Tim Julius Schulz, German Institute of Human Nutrition, Germany
Short Talk: Age-Related Changes in Bioactive Lipids Regulate Brown Adipocyte Formation and Function

Friday, February 19 | 8:00AM - 11:15AM
Adipose Tissue Remodeling
Room: Van Horne A

Speaker 5 of 7
Karine Clément, INSERM / Sorbonne Universite, France
Adipose Tissue Stiffness, Cell Size and Metabolic Function

Friday, February 19 | 8:00AM - 11:15AM
Adipose Tissue Remodeling
Room: Van Horne A

Speaker 6 of 7
Ruth E. Gimeno, Eli Lilly and Company, USA
Pharmacological Approaches to Diabetes and Metabolic Disorders

Friday, February 19 | 8:00AM - 11:15AM
Adipose Tissue Remodeling
Room: Van Horne A

Speaker 7 of 7
Peter K. Jackson, Stanford University, USA
Short Talk: The Asymmetric Cell Division Regulator Ags3/Pins Couples Primary Cilia to Insulin/IGF1 Signaling and Reprogramming of CD34+ Preadipocytes to Differentiate

Friday, February 19 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Friday, February 19 | 11:15AM - 5:00PM
On Own for Lunch


Friday, February 19 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Friday, February 19 | 5:00PM - 7:15PM
Novel CNS Pathways in Metabolic Regulation
Room: Van Horne A

Speaker 1 of 5
* Deborah Clegg, Cedars-Sinai Medical Center, USA
Hypothalamic Autophagy, Mitophagy and Lipophagy: Estrogens Regulate Them ALL!

Friday, February 19 | 5:00PM - 7:15PM
Novel CNS Pathways in Metabolic Regulation
Room: Van Horne A

Speaker 2 of 5
Xiaoyong Yang, Yale University School of Medicine, USA
Dialog Between Brain and Fat via O-GlcNAc Signaling

Friday, February 19 | 5:00PM - 7:15PM
Novel CNS Pathways in Metabolic Regulation
Room: Van Horne A

Speaker 3 of 5
* Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA
Searching for Mechanisms of Weight Loss and Diabetes Resolution after Bariatric Surgery: Are We Ready to Ditch the Knife?

Friday, February 19 | 5:00PM - 7:15PM
Novel CNS Pathways in Metabolic Regulation
Room: Van Horne A

Speaker 4 of 5
John Garretson, Albert Einstein College of Medicine, USA
Short Talk: Lipolysis Activates Sensory Nerves in White Fat

Friday, February 19 | 5:00PM - 7:15PM
Novel CNS Pathways in Metabolic Regulation
Room: Van Horne A

Speaker 5 of 5
Candice B. Herber, University of California, San Francisco, USA
Short Talk: In Vivo Imaging of a New Highly Sensitive ThermoMouse (Ucp1-Luc) Line Reveals Marked Sex-Differences in BAT Thermogenesis

Friday, February 19 | 7:15PM - 7:30PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Van Horne A


Friday, February 19 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Van Horne B/C
No registration fees are used to fund alcohol served at this function.

Friday, February 19 | 8:00PM - 11:00PM
Entertainment
Room: Van Horne B/C
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, February 19 | 8:00PM - 11:00PM
Cash Bar
Room: Van Horne B/C


Saturday, February 20 | 10:25AM - 10:25AM
Departure


*Session Chair.