Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
GPCR Structure and Function: Taking GPCR Drug Development and Discovery to the Next Level (2018B8)

Web Desc
G Protein-Coupled Receptors: Structure, Signaling and Drug Discovery Organizer(s): Arthur Christopoulos, Laura M. Bohn and Dominic P. Behan Date: February 21 - 25, 2016 Location: Keystone Resort, Keystone, CO, USA Sponsored by Arena Pharmaceuticals, Inc., Merck & Co., Inc. and Novo Nordisk A/S Summary of Meeting: The field of G protein-coupled receptors has recently seen major advances in high-resolution structure determination, as well as the validation of novel paradigms of drug action, such as allosteric modulation and biased agonism, as likely universal mechanisms. These studies are opening new insights into the diversity of this receptor superfamily, teaching us new lessons in receptor functionality and hinting at novel avenues to investigate. At the same time, we are seeing exciting discoveries in GPCR intracellular signaling and physiology. The timing is right to bring together researchers in these different areas. This Keystone Symposia meeting will focus on the interplay between these discoveries and how they are being used to advance GPCR-based research toward improved clinical outcomes. Scholarship Deadline: October 21 2015 Discounted Abstract Deadline: October 21 2015 Abstract Deadline: November 19 2015 Discounted Registration Deadline: December 21 2015 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Heptares Therapeutics Ltd Neurocrine Biosciences, Inc. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

G Protein-Coupled Receptors: Structure, Signaling and Drug Discovery

Organizer(s): Arthur Christopoulos, Laura M. Bohn and Dominic P. Behan

Date: February 21 - 25, 2016
Location: Keystone Resort, Keystone, CO, USA

Sponsored by Arena Pharmaceuticals, Inc., Merck & Co., Inc. and Novo Nordisk A/S

Summary of Meeting:

The field of G protein-coupled receptors has recently seen major advances in high-resolution structure determination, as well as the validation of novel paradigms of drug action, such as allosteric modulation and biased agonism, as likely universal mechanisms. These studies are opening new insights into the diversity of this receptor superfamily, teaching us new lessons in receptor functionality and hinting at novel avenues to investigate. At the same time, we are seeing exciting discoveries in GPCR intracellular signaling and physiology. The timing is right to bring together researchers in these different areas. This Keystone Symposia meeting will focus on the interplay between these discoveries and how they are being used to advance GPCR-based research toward improved clinical outcomes.

Scholarship Deadline: October 21 2015

Discounted Abstract Deadline: October 21 2015

Abstract Deadline: November 19 2015

Discounted Registration Deadline: December 21 2015

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Heptares Therapeutics Ltd

Neurocrine Biosciences, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, February 21 \| 4:00PM - 8:00PM Arrival and Registration Room: Keystone Lodge Lobby
Sunday, February 21 \| 6:00PM - 8:00PM Welcome Mixer Room: Keystone Lodge-Bighorn Bar No registration fees are used to fund alcohol served at this function.
Monday, February 22 \| 7:00AM - 8:00AM Breakfast Room: Shavano/Torreys
Monday, February 22 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Grays Peak Speaker 1 of 2 * Arthur Christopoulos, Monash University, Australia
Monday, February 22 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Grays Peak Speaker 2 of 2 Brian K. Kobilka, Stanford University School of Medicine, USA Structural Insights into G Protein-Coupled Receptor Signaling
Monday, February 22 \| 9:00AM - 12:15PM GPCR Structure-Function I Room: Grays Peak Speaker 1 of 7 * Brian K. Kobilka, Stanford University School of Medicine, USA
Monday, February 22 \| 9:00AM - 12:15PM GPCR Structure-Function I Room: Grays Peak Speaker 2 of 7 Laurence J. Miller, Mayo Clinic, USA Allosteric Regulation of the Type 1 Cholecystokinin Receptor
Monday, February 22 \| 9:00AM - 12:15PM GPCR Structure-Function I Room: Grays Peak Speaker 3 of 7 Patrick M. Sexton, Monash University, Australia Molecular Mechanisms Governing Signaling and Bias at Class B GPCRs
Monday, February 22 \| 9:00AM - 12:15PM GPCR Structure-Function I Room: Grays Peak Speaker 4 of 7 Tracy M. Handel, University of California, San Diego, USA Structure and Implications of the Metastasis Promoting Chemokine Receptor, CXCR4, in Complex with Chemokine.
Monday, February 22 \| 9:00AM - 12:15PM GPCR Structure-Function I Room: Grays Peak Speaker 5 of 7 Martin J. Lohse, Max Delbrück Center for Molecular Medicine, Germany Optical Monitoring of Receptor Signaling - From Molecules to Intact Organisms
Monday, February 22 \| 9:00AM - 12:15PM GPCR Structure-Function I Room: Grays Peak Speaker 6 of 7 Byron Carpenter, MRC Laboratory of Molecular Biology, UK Short Talk: Crystal Structure of the Human Adenosine A2a Receptor Bound to an Engineered G Protein
Monday, February 22 \| 9:00AM - 12:15PM GPCR Structure-Function I Room: Grays Peak Speaker 7 of 7 Philippe Rondard, Institut de Génomique Fonctionnelle, France Short Talk: Hippocampal mGlu2 Receptor Homodimers Tune Context Fear Consolidation as Revealed with Positive Allosteric Nanobodies
Monday, February 22 \| 10:20AM - 10:40AM Coffee Break Room: Longs Peak Foyer
Monday, February 22 \| 12:15PM - 1:00PM Poster Setup Room: Shavano/Torreys
Monday, February 22 \| 12:15PM - 5:00PM On Own for Lunch
Monday, February 22 \| 1:00PM - 10:00PM Poster Viewing Room: Shavano/Torreys
Monday, February 22 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, February 22 \| 5:00PM - 7:00PM GPCR Structure-Function II Room: Grays Peak Speaker 1 of 5 * Laurence J. Miller, Mayo Clinic, USA
Monday, February 22 \| 5:00PM - 7:00PM GPCR Structure-Function II Room: Grays Peak Speaker 2 of 5 Graeme Milligan, University of Glasgow, UK Exploring Novel Roles for Free Fatty Acid Receptor 4 (GPR120)
Monday, February 22 \| 5:00PM - 7:00PM GPCR Structure-Function II Room: Grays Peak Speaker 3 of 5 Michel Bouvier, University of Montreal, Canada Novel Approaches to Interrogating GPCR Signaling
Monday, February 22 \| 5:00PM - 7:00PM GPCR Structure-Function II Room: Grays Peak Speaker 4 of 5 Arthur Christopoulos, Monash University, Australia Insights into Allosteric Modulation of GPCRs
Monday, February 22 \| 5:00PM - 7:00PM GPCR Structure-Function II Room: Grays Peak Speaker 5 of 5 Alexey Bondar, Institute of Nanobiology and Structural Biology, Czech Republic Short Talk: Precoupling of G Proteins with GPCRs Visualized by Two-Photon Polarization Microscopy
Monday, February 22 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Monday, February 22 \| 7:30PM - 10:00PM Poster Session 1 Room: Shavano/Torreys
Tuesday, February 23 \| 7:00AM - 8:00AM Breakfast Room: Shavano/Torreys
Tuesday, February 23 \| 8:00AM - 11:15AM GPCRs and CNS Biology Room: Grays Peak Speaker 1 of 7 * Laura M. Bohn, The Scripps Research Institute, USA
Tuesday, February 23 \| 8:00AM - 11:15AM GPCRs and CNS Biology Room: Grays Peak Speaker 2 of 7 Marc G. Caron, Duke University Medical Center, USA Integrated Approaches to Understanding GPCRs in the CNS
Tuesday, February 23 \| 8:00AM - 11:15AM GPCRs and CNS Biology Room: Grays Peak Speaker 3 of 7 Bryan Roth, University of North Carolina at Chapel Hill, USA Illuminating a Subterranean GPCR-ome
Tuesday, February 23 \| 8:00AM - 11:15AM GPCRs and CNS Biology Room: Grays Peak Speaker 4 of 7 Jeffrey Jeffrey Conn, Vanderbilt University, USA Impact of Diverse Modes of Efficacy on Potential Therapeutic Effects of Allosteric Modulators of GPCRs
Tuesday, February 23 \| 8:00AM - 11:15AM GPCRs and CNS Biology Room: Grays Peak Speaker 5 of 7 Karen O'Malley, Washington University School of Medicine, USA Intracellular Signaling of Metabotropic Glutamate Receptors
Tuesday, February 23 \| 8:00AM - 11:15AM GPCRs and CNS Biology Room: Grays Peak Speaker 6 of 7 Christopher Wild, University of Texas Medical Branch, USA Short Talk: Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) Allosteric Modulators as Novel Neurotherapeutics
Tuesday, February 23 \| 8:00AM - 11:15AM GPCRs and CNS Biology Room: Grays Peak Speaker 7 of 7 Neah Likhite, University at Buffalo, USA Short Talk: The Protein Arginine Methyltransferase PRMT5 Promotes D2-like Dopamine Receptor Signaling
Tuesday, February 23 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Tuesday, February 23 \| 11:15AM - 1:00PM Poster Setup Room: Shavano/Torreys
Tuesday, February 23 \| 11:15AM - 5:00PM On Own for Lunch
Tuesday, February 23 \| 1:00PM - 10:00PM Poster Viewing Room: Shavano/Torreys
Tuesday, February 23 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, February 23 \| 5:00PM - 7:00PM Computational Studies of GPCRs Room: Grays Peak Speaker 1 of 5 * Patrick M. Sexton, Monash University, Australia
Tuesday, February 23 \| 5:00PM - 7:00PM Computational Studies of GPCRs Room: Grays Peak Speaker 2 of 5 Chris de Graaf, VU University Amsterdam, Netherlands Computational Medicinal Chemistry Approaches to GPCR Drug Discovery
Tuesday, February 23 \| 5:00PM - 7:00PM Computational Studies of GPCRs Room: Grays Peak Speaker 3 of 5 Brian K. Shoichet, University of California, San Francisco, USA Structure-Based and Network Pharmacology for GPCR Ligand Discovery
Tuesday, February 23 \| 5:00PM - 7:00PM Computational Studies of GPCRs Room: Grays Peak Speaker 4 of 5 Marta Filizola, Icahn School of Medicine at Mount Sinai, USA Atomistic Level Approach to Allosteric Modulation and Biased Agonism to Develop Non-Addictive Painkillers
Tuesday, February 23 \| 5:00PM - 7:00PM Computational Studies of GPCRs Room: Grays Peak Speaker 5 of 5 Nagarajan Vaidehi, City of Hope National Medical Center, USA Short Talk: Dynamics of Thermostable Mutant Receptors in Detergent Micelles
Tuesday, February 23 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Tuesday, February 23 \| 7:30PM - 10:00PM Poster Session 2 Room: Shavano/Torreys
Wednesday, February 24 \| 7:00AM - 8:00AM Breakfast Room: Shavano/Torreys
Wednesday, February 24 \| 8:00AM - 11:15AM GPCRs in Physiology and Disease Room: Grays Peak Speaker 1 of 7 * Michel Bouvier, University of Montreal, Canada
Wednesday, February 24 \| 8:00AM - 11:15AM GPCRs in Physiology and Disease Room: Grays Peak Speaker 2 of 7 Melanie H. Cobb, University of Texas Southwestern Medical Center, USA Nutrient-Sensing GPCRs in Pancreatic Beta Cells
Wednesday, February 24 \| 8:00AM - 11:15AM GPCRs in Physiology and Disease Room: Grays Peak Speaker 3 of 7 Dominic P. Behan, Sentia Medical Sciences, Inc., USA GPCR Modulation of Persistent Signaling and Energy Homeostasis with Specific Reference to Serotonin Receptors and Lorcaserin HCL’s Selectivity
Wednesday, February 24 \| 8:00AM - 11:15AM GPCRs in Physiology and Disease Room: Grays Peak Speaker 4 of 7 Lora K. Heisler, Rowett Institute, University of Aberdeen, UK GPCRs in Obesity and Type 2 Diabetes
Wednesday, February 24 \| 8:00AM - 11:15AM GPCRs in Physiology and Disease Room: Grays Peak Speaker 5 of 7 Maree Smith, University of Queensland, Australia Selective Small Molecule Angiotensin II Type 2 (AT2) for Neuropathic Pain
Wednesday, February 24 \| 8:00AM - 11:15AM GPCRs in Physiology and Disease Room: Grays Peak Speaker 6 of 7 Rui Chang, Harvard Medical School, USA Short Talk: GPCR-Based Genetic Identification of Two Sensory Neuron Types that Differentially Control Breathing
Wednesday, February 24 \| 8:00AM - 11:15AM GPCRs in Physiology and Disease Room: Grays Peak Speaker 7 of 7 Derek Bone, NIDDK, National Institutes of Health, USA Short Talk: Skeletal Muscle Gq-DREADD Signaling Greatly Enhances Glucose Tolerance and Insulin Sensitivity in Mice
Wednesday, February 24 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Wednesday, February 24 \| 11:15AM - 1:00PM Poster Setup Room: Shavano/Torreys
Wednesday, February 24 \| 11:15AM - 5:00PM On Own for Lunch
Wednesday, February 24 \| 1:00PM - 10:00PM Poster Viewing Room: Shavano/Torreys
Wednesday, February 24 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, February 24 \| 5:00PM - 7:00PM GPCR Signaling and Bias Room: Grays Peak Speaker 1 of 5 * Dominic P. Behan, Sentia Medical Sciences, Inc., USA
Wednesday, February 24 \| 5:00PM - 7:00PM GPCR Signaling and Bias Room: Grays Peak Speaker 2 of 5 Martine J. Smit, VU University Amsterdam, Netherlands Nanobodies Targeting Oncogenic GPCRs
Wednesday, February 24 \| 5:00PM - 7:00PM GPCR Signaling and Bias Room: Grays Peak Speaker 3 of 5 Louis M. Luttrell, Medical University of South Carolina, USA Impact of Ligand Bias on GPCR Signaling Networks
Wednesday, February 24 \| 5:00PM - 7:00PM GPCR Signaling and Bias Room: Grays Peak Speaker 4 of 5 Laura M. Bohn, The Scripps Research Institute, USA Biasing Opioid Receptor Signaling Away from Negative Side Effects
Wednesday, February 24 \| 5:00PM - 7:00PM GPCR Signaling and Bias Room: Grays Peak Speaker 5 of 5 Patricia H. McDonald, The Scripps Research Institute, USA Short Talk: Development and Characterization of a Long-acting GLP-1R G-protein Biased Agonist
Wednesday, February 24 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Wednesday, February 24 \| 7:30PM - 10:00PM Poster Session 3 Room: Shavano/Torreys
Thursday, February 25 \| 7:00AM - 8:00AM Breakfast Room: Shavano/Torreys
Thursday, February 25 \| 8:00AM - 11:15AM GPCR Drug Discovery Room: Grays Peak Speaker 1 of 7 * Bryan Roth, University of North Carolina at Chapel Hill, USA
Thursday, February 25 \| 8:00AM - 11:15AM GPCR Drug Discovery Room: Grays Peak Speaker 2 of 7 Christopher Langmead, Monash University, Australia Challenges and Opportunities for CNS Drug Discovery
Thursday, February 25 \| 8:00AM - 11:15AM GPCR Drug Discovery Room: Grays Peak Speaker 3 of 7 Dimitri E. Grigoriadis, Neurocrine Biosciences, Inc., USA Targeting CRF and GnRH Receptors in Central Nervous System and Endocrine Disorders
Thursday, February 25 \| 8:00AM - 11:15AM GPCR Drug Discovery Room: Grays Peak Speaker 4 of 7 Fiona H. Marshall, Heptares Therapeutics Ltd., UK Structure-Based Design Applied to Allosteric Modulators of GPCRs
Thursday, February 25 \| 8:00AM - 11:15AM GPCR Drug Discovery Room: Grays Peak Speaker 5 of 7 Alexandros Makriyannis, Northeastern University, USA The Endocannabinoid System as a Therapeutic Target
Thursday, February 25 \| 8:00AM - 11:15AM GPCR Drug Discovery Room: Grays Peak Speaker 6 of 7 Irina Kufareva, University of California, San Diego, USA Short Talk: Using the Pocketome to Identify Binding Pocket Neighbours for Surrogate Ligand Screening at Orphan G Protein-Coupled Receptors
Thursday, February 25 \| 8:00AM - 11:15AM GPCR Drug Discovery Room: Grays Peak Speaker 7 of 7 Asuka Inoue, Tohoku University, Japan Short Talk: G Protein-Depleted HEK293 Cells and Beta-Arrestin-Depleted HEK293 Cells: A Toolbox for GPCR Signaling Researches and its Application to Understanding Landscapes of G Protein Coupling
Thursday, February 25 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Thursday, February 25 \| 11:15AM - 5:00PM On Own for Lunch
Thursday, February 25 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, February 25 \| 5:00PM - 6:45PM Recent Developments in GPCR Discovery Room: Grays Peak Speaker 1 of 3 * Graeme Milligan, University of Glasgow, UK
Thursday, February 25 \| 5:00PM - 6:45PM Recent Developments in GPCR Discovery Room: Grays Peak Speaker 2 of 3 Andrew B. Tobin, University of Glasgow, UK Genetic and Chemo-Genetic Approaches to Determine the Modes of Action of G Protein Coupled-Receptors and their Ligands
Thursday, February 25 \| 5:00PM - 6:45PM Recent Developments in GPCR Discovery Room: Grays Peak Speaker 3 of 3 Ron O. Dror, Stanford University, USA Structural Basis for Nucleotide Exchange in Heterotrimeric G Proteins
Thursday, February 25 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Grays Peak
Thursday, February 25 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Thursday, February 25 \| 8:00PM - 11:00PM Entertainment Room: Shavano/Torreys Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, February 25 \| 8:00PM - 11:00PM Cash Bar Room: Shavano/Torreys
Friday, February 26 \| 10:25AM - 10:25AM Departure *Session Chair.