Web Desc
Immunity in Skin Development, Homeostasis and Disease
Organizer(s): Frank O. Nestle, Richard L. Gallo, Fiona M. Watt and Paul A. Khavari
Date: February 28 - March 02, 2016
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by an educational grant from Lilly
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Summary of Meeting:
Skin is the largest human organ and the primary interface between the human body and the environment. As such, skin plays a key role in health and well-being. Hundreds of different diseases are manifested in skin – e.g., infectious diseases, autoimmune and autoinflammatory diseases, skin cancers – and skin is a very common site of disease, leading to a substantial fraction of all visits to healthcare providers each year. Skin is also a major avenue for drug delivery and an area of increasing focus by industry, both because of unmet medical needs as well as skin’s ready accessibility relative to other organs. For example, both melanoma and psoriasis are proof-of-principle disease areas where insights into mechanism have led to therapeutic breakthroughs using targeted therapies for major patient benefit. Significant headway has been made in recent years in our understanding of normal development, homeostasis and repair in skin. With this progress has come increasing recognition of the role played by interactions between the many different types of cells in skin. A key set of interactions are those between skin cells such as keratinocytes and cells of the immune system. This meeting will provide a unique setting for in-depth discussions between skin biologists, dermatologists, immunologists and cancer biologists. More specifically, the meeting aims to: 1) Review and discuss recent progress in understanding the role of immune function in skin development, homeostasis and pathology; 2) Review and discuss the molecular and cellular basis of pathogenesis in skin diseases and targeted therapies; 3) Highlight areas of progress as well as needs and opportunities for further research; 4) Clarify concepts and models regarding interactions between skin and the immune system; 5) Highlight how research findings will be, or might be, extended to understanding disease and creating treatments; and 6) Stimulate new collaborations and foster the scientific and professional development of all attendees, with a special emphasis on trainees and early-career scientists.
Scholarship Deadline: October 28 2015
Discounted Abstract Deadline: October 28 2015
Abstract Deadline: December 1 2015
Discounted Registration Deadline: January 5 2016
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Educational grant from Lilly
We gratefully acknowledge additional support for this conference from:
ACS SensorsEducational grant from Celgene CorporationNational Psoriasis Foundation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Grant No. 1R13AR069440-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 28 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function


Sunday, February 28 | 6:00PM - 8:00PM
Welcome Mixer
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Sunday, February 28 | 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall


Monday, February 29 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, February 29 | 8:00AM - 8:15AM
Opening Remarks, Remembering Andy Robertson
Room: Mountain/Lake


Monday, February 29 | 8:15AM - 9:15AM
Keynote Address
Room: Mountain/Lake

Speaker 1 of 3
* Frank Oliver Nestle, Sanofi, USA

Monday, February 29 | 8:15AM - 9:15AM
Keynote Address
Room: Mountain/Lake

Speaker 2 of 3
* Richard L. Gallo, University of California, San Diego, USA

Monday, February 29 | 8:15AM - 9:15AM
Keynote Address
Room: Mountain/Lake

Speaker 3 of 3
Georg Stingl, University of Vienna, Austria
Cutaneous Immunity in Health and Disease – Changing Paradigms, Novel Concepts and their Translation

Monday, February 29 | 9:15AM - 12:00PM
Role of Immunity in Epithelial Differentiation
Room: Mountain/Lake

Speaker 1 of 4
Anthony Oro, Stanford University, USA
Immunologic and Environmental Regulators of Hair Growth

Monday, February 29 | 9:15AM - 12:00PM
Role of Immunity in Epithelial Differentiation
Room: Mountain/Lake

Speaker 2 of 4
Paul A. Khavari, Stanford University, USA
Genomic Control of Epidermal Differentiation

Monday, February 29 | 9:15AM - 12:00PM
Role of Immunity in Epithelial Differentiation
Room: Mountain/Lake

Speaker 3 of 4
Masayuki Amagai, Keio University, Japan
Skin Barrier Homeostasis by Stratum Corneum and Tight Junction

Monday, February 29 | 9:15AM - 12:00PM
Role of Immunity in Epithelial Differentiation
Room: Mountain/Lake

Speaker 4 of 4
* Fiona M. Watt, King's College London School of Medicine, UK
Interactions between the Epidermis, Immune System and Commensal Bacteria in Tumor Formation

Monday, February 29 | 9:50AM - 10:10AM
Coffee Break
Room: Pre Function


Monday, February 29 | 12:00PM - 1:00PM
Poster Setup
Room: Bay


Monday, February 29 | 12:00PM - 5:00PM
On Own for Lunch


Monday, February 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, February 29 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, February 29 | 5:00PM - 7:15PM
Immunity and Dysregulation of Epithelial Function
Room: Mountain/Lake

Speaker 1 of 5
Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs


Monday, February 29 | 5:00PM - 7:15PM
Immunity and Dysregulation of Epithelial Function
Room: Mountain/Lake

Speaker 2 of 5
Manolis Pasparakis, University of Cologne, Germany
Epithelial NF-kappaB and RIP Kinase Signaling in Skin Inflammation

Monday, February 29 | 5:00PM - 7:15PM
Immunity and Dysregulation of Epithelial Function
Room: Mountain/Lake

Speaker 3 of 5
Niwa Ali, University of California, San Francisco, USA
Short Talk: Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation

Monday, February 29 | 5:00PM - 7:15PM
Immunity and Dysregulation of Epithelial Function
Room: Mountain/Lake

Speaker 4 of 5
Franklin Zhong, IMB/NTU, Singapore
Short Talk: Germline NLRP1 Mutations Cause an Inherited Skin Cancer Syndrome via Spontaneous Inflammasome Activation

Monday, February 29 | 5:00PM - 7:15PM
Immunity and Dysregulation of Epithelial Function
Room: Mountain/Lake

Speaker 5 of 5
* Erwin F. Wagner, Spanish National Cancer Research Centre, Spain
Inflammatory Skin Diseases and AP-1 (Fos/Jun)

Monday, February 29 | 7:15PM - 8:15PM
Dinner
Room: Granhall


Monday, February 29 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay


Monday, February 29 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Tuesday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, March 01 | 8:00AM - 11:15AM
Skin Immunity
Room: Mountain/Lake

Speaker 1 of 6
Michel Gilliet, University Hospital of Lausanne, Switzerland
Innate Skin Immunity

Tuesday, March 01 | 8:00AM - 11:15AM
Skin Immunity
Room: Mountain/Lake

Speaker 2 of 6
Rachael A. Clark, Brigham and Women's Hospital, Harvard Medical School, USA
Skin Resident T Cells

Tuesday, March 01 | 8:00AM - 11:15AM
Skin Immunity
Room: Mountain/Lake

Speaker 3 of 6
Lingjuan Zhang, University California, San Diego, USA
Short Talk: Interferon Beta Production by the Epidermis is Mediated by an Antimicrobial Peptide and the MAVS Signaling Pathway

Tuesday, March 01 | 8:00AM - 11:15AM
Skin Immunity
Room: Mountain/Lake

Speaker 4 of 6
Robert L. Modlin, University of California, Los Angeles, USA
The Role of Langerhans Cells in Host Defense Against Bacterial Infection in Skin

Tuesday, March 01 | 8:00AM - 11:15AM
Skin Immunity
Room: Mountain/Lake

Speaker 5 of 6
James Daniel Beckett, Johns Hopkins University, USA
Short Talk: Implication of Innate Immunity in the Pathogenesis of Scleroderma

Tuesday, March 01 | 8:00AM - 11:15AM
Skin Immunity
Room: Mountain/Lake

Speaker 6 of 6
* Richard L. Gallo, University of California, San Diego, USA
The Coordinated, Layered Innate Defense System of the Skin

Tuesday, March 01 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, March 01 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, March 01 | 11:15AM - 2:30PM
On Own for Lunch


Tuesday, March 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, March 01 | 2:30PM - 4:30PM
Workshop 1: Environment and the Skin
Room: Mountain/Lake

Speaker 1 of 8
Niroshana Anandasabapathy, Weill Cornell Medicine, USA
Core Skin DC Signatures Control Immune Tolerance to Skin Cancer and Limit Anti-Tumor Immunity

Tuesday, March 01 | 2:30PM - 4:30PM
Workshop 1: Environment and the Skin
Room: Mountain/Lake

Speaker 2 of 8
Hisato Iriki, Keio University, Japan
Deletion of T Cells Specific to Desmoglein 3, a Pemphigus Autoantigen, by Peripheral Tolerance

Tuesday, March 01 | 2:30PM - 4:30PM
Workshop 1: Environment and the Skin
Room: Mountain/Lake

Speaker 3 of 8
Sakeen Kashem, University of Minnesota, USA
Nociceptive Sensory Fibers Induce IL-23 from CD301b+ Dermal Dendritic Cell and Drive Protective Cutaneous Immunity

Tuesday, March 01 | 2:30PM - 4:30PM
Workshop 1: Environment and the Skin
Room: Mountain/Lake

Speaker 4 of 8
* Padraic Fallon, Trinity College Dublin, Ireland
Microbiome Regulation of IL-17 Mediated-Skin Inflammation due to Filaggrin Deficiency

Tuesday, March 01 | 2:30PM - 4:30PM
Workshop 1: Environment and the Skin
Room: Mountain/Lake

Speaker 5 of 8
Allyson Byrd, Genentech, Inc., USA
Tracking Strains of Staphylococci during Human Atopic Dermatitis Disease Progression

Tuesday, March 01 | 2:30PM - 4:30PM
Workshop 1: Environment and the Skin
Room: Mountain/Lake

Speaker 6 of 8
Sarah Jill de Jong, Rockefeller University, USA
EV3 Deficiency as a New Genetic Etiology of Epidermodysplasia Verruciformis

Tuesday, March 01 | 2:30PM - 4:30PM
Workshop 1: Environment and the Skin
Room: Mountain/Lake

Speaker 7 of 8
Dawn Zhang Eichenfield, University of California, San Diego, USA
Tissue Damage Signals Repurpose Transcription Factors to Direct a Rev-erb Sensitive Wound Repair Program in Macrophages

Tuesday, March 01 | 2:30PM - 4:30PM
Workshop 1: Environment and the Skin
Room: Mountain/Lake

Speaker 8 of 8
Thomas H. Leung, University of Pennsylvania, USA
Role of Immunity in Mouse Appendage Regeneration

Tuesday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, March 01 | 5:00PM - 7:00PM
Skin Microbiome
Room: Mountain/Lake

Speaker 1 of 4
Christina E. Zielinski, Technical University Munich, Germany
Regulation of Pro- and Anti-Inflammatory Human T Helper Cell Functions by the Microenvironment

Tuesday, March 01 | 5:00PM - 7:00PM
Skin Microbiome
Room: Mountain/Lake

Speaker 2 of 4
Björn Andersson, Karolinska Institutet, Sweden
Characterization of the Skin Microbiome in a Large European Skin Disease Cohort

Tuesday, March 01 | 5:00PM - 7:00PM
Skin Microbiome
Room: Mountain/Lake

Speaker 3 of 4
Tiffany C. Scharschmidt, University of California, San Francisco, USA
Short Talk: Commensal Microbes Augment Expression of the Hair Follicle Chemokine CCL20 to Facilitate Accumulation of Tregs in Neonatal Skin

Tuesday, March 01 | 5:00PM - 7:00PM
Skin Microbiome
Room: Mountain/Lake

Speaker 4 of 4
* Yasmine Belkaid, NIAID, National Institutes of Health, USA
Impact of the Skin Microbiota on Skin Immunity and Inflammation

Tuesday, March 01 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, March 01 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay


Tuesday, March 01 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Wednesday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, March 02 | 8:00AM - 11:15AM
Immune Pathways and Therapeutic Targets in Skin Disease I
Room: Mountain/Lake

Speaker 1 of 5
James G. Krueger, Rockefeller University, USA
Principles of Targeted Therapies

Wednesday, March 02 | 8:00AM - 11:15AM
Immune Pathways and Therapeutic Targets in Skin Disease I
Room: Mountain/Lake

Speaker 2 of 5
Emma Guttman, Mount Sinai Hospital, USA
A Paradigm Shift in the Pathogenesis and Therapeutics of Atopic Dermatitis

Wednesday, March 02 | 8:00AM - 11:15AM
Immune Pathways and Therapeutic Targets in Skin Disease I
Room: Mountain/Lake

Speaker 3 of 5
John J. O'Shea, NIAMS, National Institutes of Health, USA
Jak Kinases in Tissue Immunity

Wednesday, March 02 | 8:00AM - 11:15AM
Immune Pathways and Therapeutic Targets in Skin Disease I
Room: Mountain/Lake

Speaker 4 of 5
Wenjun Ouyang, Amgen, Inc., USA
IL-20 Subfamily Cytokines in Skin Inflammation and Wound Healing


Wednesday, March 02 | 8:00AM - 11:15AM
Immune Pathways and Therapeutic Targets in Skin Disease I
Room: Mountain/Lake

Speaker 5 of 5
* Frank Oliver Nestle, Sanofi, USA
Skin Inflammation: Gene and Environment Interplay

Wednesday, March 02 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, March 02 | 11:15AM - 2:30PM
On Own for Lunch


Wednesday, March 02 | 2:30PM - 4:30PM
Workshop 2: Inflammatory Skin Disease: More than Skin Deep.
Sponsored by the National Psoriasis Foundation in Memory of Andy Robertson.
Room: Mountain/Lake

Speaker 1 of 4
Michael D. Rosenblum, University of California, San Francisco, USA
Tregs in Skin Facilitate Epithelial Stem Cell Differentiation

Wednesday, March 02 | 2:30PM - 4:30PM
Workshop 2: Inflammatory Skin Disease: More than Skin Deep.
Sponsored by the National Psoriasis Foundation in Memory of Andy Robertson.
Room: Mountain/Lake

Speaker 2 of 4
Kevin D. Cooper, Case Western Reserve University, USA
Vascular and Thrombotic Consequences of Chronic Skin Inflammation

Wednesday, March 02 | 2:30PM - 4:30PM
Workshop 2: Inflammatory Skin Disease: More than Skin Deep.
Sponsored by the National Psoriasis Foundation in Memory of Andy Robertson.
Room: Mountain/Lake

Speaker 3 of 4
* Angela M. Christiano, Columbia University, USA
Efficacy of JAK Inhibitors in the Treatment of Alopecia Areata

Wednesday, March 02 | 2:30PM - 4:30PM
Workshop 2: Inflammatory Skin Disease: More than Skin Deep.
Sponsored by the National Psoriasis Foundation in Memory of Andy Robertson.
Room: Mountain/Lake

Speaker 4 of 4
Teruki Dainichi, Kyoto University Graduate School of Medicine, Japan
Imiquimod-Induced Psoriasis-Like Dermatitis Depends on TRAF6-Mediated Transcriptional Activation of Keratinocytes

Wednesday, March 02 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, March 02 | 5:00PM - 6:45PM
Immune Pathways and Therapeutic Targets in Skin Disease II
Room: Mountain/Lake

Speaker 1 of 3
Lisa A. Beck, University of Rochester Medical Center, USA
Targeting Type 2 Skin Inflammation: Implications for Atopic Disease

Wednesday, March 02 | 5:00PM - 6:45PM
Immune Pathways and Therapeutic Targets in Skin Disease II
Room: Mountain/Lake

Speaker 2 of 3
Thomas Krieg, Biochemistry, Germany
Cellular and Molecular Mechanisms of Fibrosis
- Scleroderma as a Model Disease


Wednesday, March 02 | 5:00PM - 6:45PM
Immune Pathways and Therapeutic Targets in Skin Disease II
Room: Mountain/Lake

Speaker 3 of 3
* Thomas S. Kupper, Brigham and Women's Hospital, USA
Lineage Commitment of Memory T Cell Precursors: Implications for Allergic Contact Dermatitis and Other Skin Diseases

Wednesday, March 02 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Mountain/Lake

Speaker 1 of 2
* Fiona M. Watt, King's College London School of Medicine, UK

Wednesday, March 02 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Mountain/Lake

Speaker 2 of 2
* Paul A. Khavari, Stanford University, USA

Wednesday, March 02 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Wednesday, March 02 | 7:00PM - 8:00PM
Social Hour
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Wednesday, March 02 | 8:00PM - 11:00PM
Entertainment
Room: Granhall
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Wednesday, March 02 | 8:00PM - 11:00PM
Cash Bar
Room: Granhall


Thursday, March 03 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.