Web Desc
Stem Cells and Cancer
Organizer(s): Austin Gurney, Connie J. Eaves and Jane E. Visvader
Date: March 06 - 10, 2016
Location: Beaver Run Resort, Breckenridge, CO, USA
Sponsored by Bayer HealthCare Pharmaceuticals, BioLegend, Inc., Journal of Molecular Cell Biology (JMCB), OncoMed Pharmaceuticals, Inc. and Roche
Summary of Meeting:
Cancer stem cells have now been recognized in a wide variety of human tumors. The existence of cancer stem cells poses both tremendous challenges and tantalizing potential for our ability to successfully combat cancer. This Keystone Symposia meeting aims to bring together scientists who are interested in better understanding the mechanisms by which cancer stem cells contribute to tumor heterogeneity, self-renewal and drug resistance. One area of emphasis will be intercellular communication. Cellular context and microenvironment establish the tumor niche and shape the interaction of the tumor with the immune system. In addition, developmental signal transduction pathways such as Hippo, Notch and Wnt, frequently deregulated in cancer, increasingly offer tangible opportunities for therapeutic intervention. Another important area of emphasis will be efforts to better understand the mechanisms and importance of tumor heterogeneity. Techniques such as clonal analysis and barcoding are shedding important light on the interplay between tumor evolution, differentiation, miRNA control and epigenetics. This is an era of rapid progress in understanding cancer stem cell biology with great potential to benefit human health.
Scholarship Deadline: November 4 2015
Discounted Abstract Deadline: November 4 2015
Abstract Deadline: December 7 2015
Discounted Registration Deadline: January 6 2016
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer HealthCare PharmaceuticalsBioLegend, Inc.Journal of Molecular Cell Biology (JMCB)OncoMed Pharmaceuticals, Inc.Roche
We gratefully acknowledge additional support for this conference from:
ACS SensorsPeproTech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA200143-01
Funding for this conference was made possible (in part) by 1R13CA200143-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 06 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Sunday, March 06 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Monday, March 07 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Colorado Ballroom
Provide a stimulating and dynamic overview of some of the major ideas and trends shaping the field.
Speaker 1 of 2
* Jane E. Visvader, Walter and Eliza Hall Institute of Medical Research, Australia

Monday, March 07 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Colorado Ballroom
Provide a stimulating and dynamic overview of some of the major ideas and trends shaping the field.
Speaker 2 of 2
Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Oxidative Stress Inhibits Distant Metastasis by Human Melanoma Cells

Monday, March 07 | 9:00AM - 11:15AM
Stem Cell Concepts and Models
Room: Colorado Ballroom
Stability and reversibility of the stem cell state, lessons from model systems, comparisons with normal stem cells and self-renewal.
Speaker 1 of 4
* Jane E. Visvader, Walter and Eliza Hall Institute of Medical Research, Australia
Deciphering the Mammary Epithelial Hierarchy

Monday, March 07 | 9:00AM - 11:15AM
Stem Cell Concepts and Models
Room: Colorado Ballroom
Stability and reversibility of the stem cell state, lessons from model systems, comparisons with normal stem cells and self-renewal.
Speaker 2 of 4
Eirini P. Papapetrou, Icahn School of Medicine at Mount Sinai, USA
Modeling Myeloid Malignancies with Human Pluripotent Stem Cells

Monday, March 07 | 9:00AM - 11:15AM
Stem Cell Concepts and Models
Room: Colorado Ballroom
Stability and reversibility of the stem cell state, lessons from model systems, comparisons with normal stem cells and self-renewal.
Speaker 3 of 4
Ali Turhan, University Paris Sud 11, France
Modeling Cancer Using Human iPSC

Monday, March 07 | 9:00AM - 11:15AM
Stem Cell Concepts and Models
Room: Colorado Ballroom
Stability and reversibility of the stem cell state, lessons from model systems, comparisons with normal stem cells and self-renewal.
Speaker 4 of 4
Marc Leushacke, Agency for Science, Technology and Research (A*STAR), Singapore
Short Talk: Lgr5+ Stem Cells in Epithelial Homeostasis and Disease of the Stomach

Monday, March 07 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer


Monday, March 07 | 11:15AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Monday, March 07 | 11:15AM - 5:00PM
On Own for Lunch


Monday, March 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Monday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, March 07 | 5:00PM - 7:00PM
Intercellular Interactions: Non-Cell Autonomous CSC Biology
Room: Colorado Ballroom
Cooperativity, niche and immune interaction.
Speaker 1 of 4
* Carla F. Kim, Boston Children's Hospital, USA
Lung Cancer Stem Cells

Monday, March 07 | 5:00PM - 7:00PM
Intercellular Interactions: Non-Cell Autonomous CSC Biology
Room: Colorado Ballroom
Cooperativity, niche and immune interaction.
Speaker 2 of 4
Dominique A. Bonnet, Francis Crick Institute, UK
Modulation of Mesenchymal Stroma Cells by Acute Myeloid Leukemia

Monday, March 07 | 5:00PM - 7:00PM
Intercellular Interactions: Non-Cell Autonomous CSC Biology
Room: Colorado Ballroom
Cooperativity, niche and immune interaction.
Speaker 3 of 4
Christian Steidl, University of British Columbia, Canada
Targeting the Tumor-Host Cellular Interface in Lymphoid Malignancies

Monday, March 07 | 5:00PM - 7:00PM
Intercellular Interactions: Non-Cell Autonomous CSC Biology
Room: Colorado Ballroom
Cooperativity, niche and immune interaction.
Speaker 4 of 4
Takahiko Murayama, University of Tokyo, Japan
Short Talk: CD74-NRG1, a Fusion Gene Product, Leads to ErbB-NFkappaB-IGF2 Autocrine/Paracrine Circuit and Confers Cancer Stem Cell Properties

Monday, March 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, March 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Breckenridge Ballroom


Tuesday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Tuesday, March 08 | 8:00AM - 11:00AM
Tumorigenesis
Room: Colorado Ballroom
Control of birth, dormancy and expansion of normal and malignant stem cells/de novo human tumorigenesis.
Speaker 1 of 5
* Connie J. Eaves, British Columbia Cancer Agency, Canada
Barcoding to Analyze De Novo Generated and Established Human Breast Cancers

Tuesday, March 08 | 8:00AM - 11:00AM
Tumorigenesis
Room: Colorado Ballroom
Control of birth, dormancy and expansion of normal and malignant stem cells/de novo human tumorigenesis.
Speaker 2 of 5
Richard J. Gilbertson, University of Cambridge, UK
Multi-Organ Mapping of Cancer Risk

Tuesday, March 08 | 8:00AM - 11:00AM
Tumorigenesis
Room: Colorado Ballroom
Control of birth, dormancy and expansion of normal and malignant stem cells/de novo human tumorigenesis.
Speaker 3 of 5
Hanno Glimm, National Center for Tumor Diseases, Germany
Stem Cell Kinetics in Gastrointestinal Cancers

Tuesday, March 08 | 8:00AM - 11:00AM
Tumorigenesis
Room: Colorado Ballroom
Control of birth, dormancy and expansion of normal and malignant stem cells/de novo human tumorigenesis.
Speaker 4 of 5
Emmanuelle Passegué, Columbia University, USA
Hijacking of Emergency Myelopoiesis Pathways in Myeloid Leukemia

Tuesday, March 08 | 8:00AM - 11:00AM
Tumorigenesis
Room: Colorado Ballroom
Control of birth, dormancy and expansion of normal and malignant stem cells/de novo human tumorigenesis.
Speaker 5 of 5
Xiling Shen, Duke University, USA
Short Talk: lncRNA and microRNA Synergize to Regulate Colon Cancer Stem Cell Asymmetry and Plasticity

Tuesday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, March 08 | 11:00AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Tuesday, March 08 | 11:00AM - 2:30PM
On Own for Lunch


Tuesday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Tuesday, March 08 | 2:30PM - 4:30PM
Workshop
Room: Colorado Ballroom

Speaker 1 of 8
* Nagarajan Kannan, BC Cancer Research Center, Canada
Human Mammary Luminal Progenitor Cells use Oxidative Stress Signals to Regulate Signaling and Growth

Tuesday, March 08 | 2:30PM - 4:30PM
Workshop
Room: Colorado Ballroom

Speaker 2 of 8
Alexander T. Pearson, University of Michigan, USA
Using Single-Cell Observations and Mathematical Modeling to Predict Tumor Cell Growth and Cancer Stem Cell Proportion In-Vitro and In-Vivo

Tuesday, March 08 | 2:30PM - 4:30PM
Workshop
Room: Colorado Ballroom

Speaker 3 of 8
Bryan A. Smith, University of California, Los Angeles, USA
A Basal Stem Cell Signature Identifies Aggressive Prostate Cancer Phenotypes

Tuesday, March 08 | 2:30PM - 4:30PM
Workshop
Room: Colorado Ballroom

Speaker 4 of 8
Min Wang, OncoMed Pharmaceuticals, USA
Identification of a Pancreatic Tumorigenic CSC Gene Signature and Demonstration of its Suppression in Pancreas PDX Models and in Patient Tumors by Treatment with an Anti-CSC Antibody, Tarextumab (TRXT)

Tuesday, March 08 | 2:30PM - 4:30PM
Workshop
Room: Colorado Ballroom

Speaker 5 of 8
Nils Degrauwe, University of Lausanne, Switzerland
IMP2 Provides an Alternative to LIN28B for Glioma Stem Cell Maintenance

Tuesday, March 08 | 2:30PM - 4:30PM
Workshop
Room: Colorado Ballroom

Speaker 6 of 8
Tuomas Tammela, Koch Institute for Integrative Cancer Research at MIT, USA
Molecular Mechanisms Orchestrating Intratumoral Heterogeneity in Kras-Driven Carcinomas

Tuesday, March 08 | 2:30PM - 4:30PM
Workshop
Room: Colorado Ballroom

Speaker 7 of 8
Diwakar R. Pattabiraman, Geisel School of Medicine, Dartmouth College, USA
Activation of PKA Induces a Mesenchymal-to-Epithelial Transition and Loss of Tumor-Initiating Ability of Breast Carcinomas

Tuesday, March 08 | 2:30PM - 4:30PM
Workshop
Room: Colorado Ballroom

Speaker 8 of 8
Jatin Roper, Koch Institute for Integrative Cancer Research at MIT, USA
Sequential Genome Editing in CRISPR/Cas9-based Colorectal Cancer Mouse Models

Tuesday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, March 08 | 5:00PM - 7:00PM
Disregulation of Stem/Developmental Pathways
Room: Colorado Ballroom
Exploration of the role of developmental pathways (eg. Notch, Wnt, Hippo, BMP, RSPO) in CSC biology.
Speaker 1 of 4
* Stefano Piccolo, University of Padua, Italy
Yap/Taz Regulation in Stem Cells and Cancer

Tuesday, March 08 | 5:00PM - 7:00PM
Disregulation of Stem/Developmental Pathways
Room: Colorado Ballroom
Exploration of the role of developmental pathways (eg. Notch, Wnt, Hippo, BMP, RSPO) in CSC biology.
Speaker 2 of 4
Jon C. Aster, Brigham and Women's Hospital, USA
Myb-Notch-p63 Transcriptional Hierarchies in Adenoid Cystic Carcinoma

Tuesday, March 08 | 5:00PM - 7:00PM
Disregulation of Stem/Developmental Pathways
Room: Colorado Ballroom
Exploration of the role of developmental pathways (eg. Notch, Wnt, Hippo, BMP, RSPO) in CSC biology.
Speaker 3 of 4
Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany
Mechanisms Influencing Intestinal Tumorigenesis

Tuesday, March 08 | 5:00PM - 7:00PM
Disregulation of Stem/Developmental Pathways
Room: Colorado Ballroom
Exploration of the role of developmental pathways (eg. Notch, Wnt, Hippo, BMP, RSPO) in CSC biology.
Speaker 4 of 4
Zahra Kabiri, Duke University, USA
Short Talk: RSPO3 is the Gatekeeper of Wnt/Beta-Catenin Signaling in Intestinal Stem Cell Niche

Tuesday, March 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, March 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Breckenridge Ballroom


Wednesday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Wednesday, March 09 | 8:00AM - 11:00AM
Understanding Tumor Heterogeneity
Room: Colorado Ballroom
EMT, plasticity, lineage tracing, clonal tracking and tumors as evolving ecosystems.
Speaker 1 of 5
* Michael F. Clarke, Stanford University, USA
Clinical Implications of Regulators of Self-Renewal in Cancer

Wednesday, March 09 | 8:00AM - 11:00AM
Understanding Tumor Heterogeneity
Room: Colorado Ballroom
EMT, plasticity, lineage tracing, clonal tracking and tumors as evolving ecosystems.
Speaker 2 of 5
Dean G. Tang, Roswell Park Cancer Institute, USA
Prostate Cancer Stem Cells: Molecular Understanding and Clinical Implications

Wednesday, March 09 | 8:00AM - 11:00AM
Understanding Tumor Heterogeneity
Room: Colorado Ballroom
EMT, plasticity, lineage tracing, clonal tracking and tumors as evolving ecosystems.
Speaker 3 of 5
Samuel Aparicio, University of British Columbia, Canada
Genomic and Clonal Analysis of Breast Cancer

Wednesday, March 09 | 8:00AM - 11:00AM
Understanding Tumor Heterogeneity
Room: Colorado Ballroom
EMT, plasticity, lineage tracing, clonal tracking and tumors as evolving ecosystems.
Speaker 4 of 5
Catherine A. O'Brien, University Health Network, Canada
Regulation of Self-Renewal in Colon Cancer Stem Cells

Wednesday, March 09 | 8:00AM - 11:00AM
Understanding Tumor Heterogeneity
Room: Colorado Ballroom
EMT, plasticity, lineage tracing, clonal tracking and tumors as evolving ecosystems.
Speaker 5 of 5
Devraj Basu, University of Pennsylvania, USA
Short Talk: Transition Between Two Distinct Stem Cell-Like States in Head and Neck Cancer is Mediated by JARID1B

Wednesday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, March 09 | 11:00AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Wednesday, March 09 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, March 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Wednesday, March 09 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 09 | 5:00PM - 7:00PM
Emerging Targets
Room: Colorado Ballroom
New therapeutic opportunities to target CSCs.
Speaker 1 of 4
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Metabolic Adaptation in Cancer Cells-Exploiting Cancer Metabolic Vulnerabilities

Wednesday, March 09 | 5:00PM - 7:00PM
Emerging Targets
Room: Colorado Ballroom
New therapeutic opportunities to target CSCs.
Speaker 2 of 4
* Tessa L. Holyoake, University of Glasgow, UK
CML - Aiming for Cure

Wednesday, March 09 | 5:00PM - 7:00PM
Emerging Targets
Room: Colorado Ballroom
New therapeutic opportunities to target CSCs.
Speaker 3 of 4
Biniam Adane, University of Colorado School of Medicine, USA
Short Talk: The Role of NADPH Oxidase 2 in Normal and Malignant Hematopoiesis

Wednesday, March 09 | 5:00PM - 7:00PM
Emerging Targets
Room: Colorado Ballroom
New therapeutic opportunities to target CSCs.
Speaker 4 of 4
Jingwei Cheng, Dana-Farber Cancer Institute, USA
Short Talk: TRRAP-EP400-Tip60 Complex and Max Interaction is Required in iPS Generation and Oncogenesis Promotion

Wednesday, March 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, March 09 | 7:30PM - 10:00PM
Poster Session 3
Room: Breckenridge Ballroom


Thursday, March 10 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Thursday, March 10 | 8:00AM - 11:00AM
Targeting Cancer Stem Cells: Trials and Translation
Room: Colorado Ballroom
Therapeutic strategies for targeting CSC in the clinic.
Speaker 1 of 4
* Austin Gurney, Napa Biotechnology Consulting, USA
Therapeutic Agents Targeting the Wnt, Notch, and RSPO/LGR Pathways in Cancer

Thursday, March 10 | 8:00AM - 11:00AM
Targeting Cancer Stem Cells: Trials and Translation
Room: Colorado Ballroom
Therapeutic strategies for targeting CSC in the clinic.
Speaker 2 of 4
Jonathan A. Pachter, Verastem, USA
Targeting Cancer Stem Cells with Selective Inhibitors of FAK and PI3K/mTOR

Thursday, March 10 | 8:00AM - 11:00AM
Targeting Cancer Stem Cells: Trials and Translation
Room: Colorado Ballroom
Therapeutic strategies for targeting CSC in the clinic.
Speaker 3 of 4
Feng Cong, Novartis Institutes for BioMedical Research, USA
Small Molecule Inhibitors of Wnt Signaling for Cancer

Thursday, March 10 | 8:00AM - 11:00AM
Targeting Cancer Stem Cells: Trials and Translation
Room: Colorado Ballroom
Therapeutic strategies for targeting CSC in the clinic.
Speaker 4 of 4
Scott J. Dylla, Stemcentrx, Inc., USA
Short Talk: A DLL3-targeted ADC Eradicates High-Grade Pulmonary Neuroendocrine Tumor-Initiating Cells

Thursday, March 10 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, March 10 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, March 10 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, March 10 | 5:00PM - 5:45PM
Keynote Address
Room: Colorado Ballroom

Speaker 1 of 2
* Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada

Thursday, March 10 | 5:00PM - 5:45PM
Keynote Address
Room: Colorado Ballroom

Speaker 2 of 2
Hans C. Clevers, Hubrecht Institute, Netherlands
Lgr5 Stem Cell Organoids and Disease

Thursday, March 10 | 5:45PM - 7:30PM
New Horizons
Room: Colorado Ballroom
CSC metabolism, ROS involvement-control, epigenetics and miRNA.
Speaker 1 of 4
* Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada

Thursday, March 10 | 5:45PM - 7:30PM
New Horizons
Room: Colorado Ballroom
CSC metabolism, ROS involvement-control, epigenetics and miRNA.
Speaker 2 of 4
Huiping Liu, Northwestern University, USA
MicroRNAs Regulating Breast Cancer Stem Cells and Metastasis

Thursday, March 10 | 5:45PM - 7:30PM
New Horizons
Room: Colorado Ballroom
CSC metabolism, ROS involvement-control, epigenetics and miRNA.
Speaker 3 of 4
Luke Gilbert, University of California, San Francisco, USA
Retooling CRISPR to Turn Genes On and Off

Thursday, March 10 | 5:45PM - 7:30PM
New Horizons
Room: Colorado Ballroom
CSC metabolism, ROS involvement-control, epigenetics and miRNA.
Speaker 4 of 4
David M. Gilbert, Florida State University, USA
Investigations of Altered DNA Replication Timing in Human Pediatric Leukemia

Thursday, March 10 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, March 10 | 8:00PM - 11:00PM
Entertainment
Room: Breckenridge Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 10 | 8:00PM - 11:00PM
Cash Bar
Room: Breckenridge Ballroom


Friday, March 11 | 10:25AM - 10:25AM
Departure


*Session Chair.