Web Desc
Nucleic Acid Sensing Pathways: Innate Immunity, Immunobiology and Therapeutics
Organizer(s): Thomas Tuschl, Veit Hornung and Karl-Peter Hopfner
Date: May 08 - 12, 2016
Location: Maritim Hotel & International Congress Center Dresden, Dresden, Germany
Sponsored by DFG Deutsche Forschungsgemeinschaft
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Summary of Meeting:
Human cells possess intricate nucleic acid recognition processes for monitoring cellular stress and pathogen infection, which trigger the production and release of interferons and cytokines to alert neighboring cells including cells of the immune system. Various classes of nucleic acid sensors, each specific to detecting modified or unmodified, structured or unstructured DNA or RNA, have been identified and are characterized by distinct subcellular localization and also cell-type-specific expression patterns. These sensors include various nucleotidyl transferases producing second messenger small ribonucleic nucleic acid molecules as well as membrane-bound receptors ultimately leading to phosphorylation of transcription factors driving cytokine and interferon expression. This meeting focuses on cytoplasmic DNA and RNA sensors and the function of their linear and circular oligonucleotide second messenger cGAMP and 2’,5’-oligoadenylate produced upon activation. Substantial progress has been made in identification of the structures of these sensors, their nucleic acid ligands and second messenger molecules, as well as the underlying molecular pathways leading to transcriptional activation. Animal models inactivating various pathways of innate immunity have been developed. This progress has enabled targeted development of antagonists and agonists of cytokine and interferon production for therapeutic targeting of inflammatory diseases and vaccine adjuvant development, respectively. An international group of academic and industry scientists and clinicians with expertise in biochemistry and structural biology, nucleic acid chemistry, immunology, human genetics, virology, rheumatology and vaccine development will converge at this meeting to discuss the latest developments in this field.
Scholarship Deadline: January 7 2016
Discounted Abstract Deadline: January 7 2016
Abstract Deadline: February 9 2016
Discounted Registration Deadline: March 8 2016
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
DFG Deutsche Forschungsgemeinschaft
We gratefully acknowledge additional support for this conference from:
Aduro BiotechBIOLOG Life Science Institute
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI122351-01
Funding for this conference was made possible [in part] by 1 R13 AI 122351 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, May 08 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Sunday, May 08 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Monday, May 09 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotels


Monday, May 09 | 8:00AM - 8:30AM
Poster Setup
Room: Saal 4/5


Monday, May 09 | 8:30AM - 7:00PM
Poster Viewing
Room: Saal 4/5


Monday, May 09 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Saal 4/5
Key Discoveries
Speaker 1 of 2
* Thomas Tuschl, HHMI/Rockefeller University, USA

Monday, May 09 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Saal 4/5
Key Discoveries
Speaker 2 of 2
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
The cGAS Pathway of Cytosolic DNA Sensing and Its Role in Health and Diseases

Monday, May 09 | 9:30AM - 12:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System

Room: Saal 4/5

Speaker 1 of 4
Kensuke Miyake, Institute of Medical Science, University of Tokyo, Japan
RNA-Sensing and Trafficking of TLR7 in Plasmacytoid Dendritic Cells

Monday, May 09 | 9:30AM - 12:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System

Room: Saal 4/5

Speaker 2 of 4
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Regulation of Inflammation by Long Non-Coding RNAs

Monday, May 09 | 9:30AM - 12:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System

Room: Saal 4/5

Speaker 3 of 4
Petro Starokadomskyy, University of Texas Southwestern Medical Center, USA
Short Talk: DNA Polymerase-alpha Regulates Type I Interferon Activation through Cytosolic RNA:DNA Synthesis

Monday, May 09 | 9:30AM - 12:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System

Room: Saal 4/5

Speaker 4 of 4
Kachiko Hayashi, Yale University, USA
Short Talk: Toll-Like Receptor 9 Trafficking and Signaling for Type I Interferons Requires PIKfyve Activity

Monday, May 09 | 10:10AM - 10:30AM
Coffee Break
Room: Foyer


Monday, May 09 | 12:00PM - 12:45PM
Lunch
Room: Conference Ctr Restaurant


Monday, May 09 | 12:30PM - 2:30PM
Poster Session 1
Room: Saal 4/5


Monday, May 09 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, May 09 | 5:00PM - 7:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System II

Room: Saal 4/5

Speaker 1 of 4
* Veit Hornung, Ludwig-Maximilians-University Munich, Germany
Molecular Mechanisms of Nucleic Acid Pattern Recognition

Monday, May 09 | 5:00PM - 7:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System II

Room: Saal 4/5

Speaker 2 of 4
Timothy W. Behrens, Genentech, Inc., USA
Nucleic Acid Sensing and Interferon Signatures

Monday, May 09 | 5:00PM - 7:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System II

Room: Saal 4/5

Speaker 3 of 4
Russell E. Vance, University of California, Berkeley, USA
No Perfect PAMPs? Innate Immune Recognition of Nucleic Acids versus Proteins

Monday, May 09 | 5:00PM - 7:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System II

Room: Saal 4/5

Speaker 4 of 4
Tan Nguyen, Walter and Eliza Hall Institute, Australia
Short Talk: Sidt2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

Monday, May 09 | 7:00PM - 7:00PM
On Own for Dinner


Tuesday, May 10 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotels


Tuesday, May 10 | 8:30AM - 11:45AM
Structural Biology of Innate Immune Sensing
Room: Saal 4/5

Speaker 1 of 6
* Karl-Peter Hopfner, Ludwig-Maximilians-University Munich, Germany
Integrated ATP Dependent Mechanism for RIG-I’s Distinction between Self and Non-Self RNA

Tuesday, May 10 | 8:30AM - 11:45AM
Structural Biology of Innate Immune Sensing
Room: Saal 4/5

Speaker 2 of 6
Sun Hur, Harvard Medical School, USA
Molecular Mechanism of RIG-I-Like Receptors

Tuesday, May 10 | 8:30AM - 11:45AM
Structural Biology of Innate Immune Sensing
Room: Saal 4/5

Speaker 3 of 6
Alexei Korennykh, Princeton University, USA
Innate Immune Signaling via RNA Cleavage

Tuesday, May 10 | 8:30AM - 11:45AM
Structural Biology of Innate Immune Sensing
Room: Saal 4/5

Speaker 4 of 6
Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Structural Elucidation of Inflammasome Activation and Regulation

Tuesday, May 10 | 8:30AM - 11:45AM
Structural Biology of Innate Immune Sensing
Room: Saal 4/5

Speaker 5 of 6
Pingwei Li, Texas A&M University, USA
Short Talk: The Structural Basis of IRF-3 Recruitment, Activation, and Targeting in Innate Immunity

Tuesday, May 10 | 8:30AM - 11:45AM
Structural Biology of Innate Immune Sensing
Room: Saal 4/5

Speaker 6 of 6
Philip J. Kranzusch, University of California, Berkeley, USA
Short Talk: Ancient cGAS-STING Pathways Reveal Evolution of Human Innate Immunity

Tuesday, May 10 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Tuesday, May 10 | 11:45AM - 3:00PM
On Own for Lunch


Tuesday, May 10 | 11:45AM - 1:00PM
Poster Setup
Room: Saal 4/5


Tuesday, May 10 | 1:00PM - 8:30PM
Poster Viewing
Room: Saal 4/5


Tuesday, May 10 | 3:00PM - 3:30PM
Coffee Available
Room: Foyer


Tuesday, May 10 | 3:30PM - 5:30PM
Virology and Innate Inflammatory Responses
Room: Saal 4/5

Speaker 1 of 5
Jae U. Jung, Keck School of Medicine of University of Southern California, USA
Host Nucleic Acid Sensing and Viral Evasion

Tuesday, May 10 | 3:30PM - 5:30PM
Virology and Innate Inflammatory Responses
Room: Saal 4/5

Speaker 2 of 5
Ian Thomas Lamborn, NIAID, National Institutes of Health, USA
Short Talk: Human MDA5 Protects Against Severe Respiratory Infections

Tuesday, May 10 | 3:30PM - 5:30PM
Virology and Innate Inflammatory Responses
Room: Saal 4/5

Speaker 3 of 5
* Nicolas Manel, Institut Curie, France
Sensing Mechanisms of Viral Infection

Tuesday, May 10 | 3:30PM - 5:30PM
Virology and Innate Inflammatory Responses
Room: Saal 4/5

Speaker 4 of 5
Fanxiu Zhu, Florida State University, USA
Short Talk: KicGAS, KSHV Inhibitor of cGAS

Tuesday, May 10 | 3:30PM - 5:30PM
Virology and Innate Inflammatory Responses
Room: Saal 4/5

Speaker 5 of 5
Kareen Bartsch, Christian-Albrechts-University, Germany
Short Talk: RNaseH2 Deficiency Leads to Cytosolic Accumulation of Immunostimulatory DNA that is Removed by Autophagy

Tuesday, May 10 | 5:30PM - 6:30PM
Social Hour with Lite Bites
Room: Conference Ctr Restaurant
No registration fees are used to fund alcohol served at this function.

Tuesday, May 10 | 6:00PM - 8:30PM
Poster Session 2
Room: Saal 4/5


Wednesday, May 11 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotels


Wednesday, May 11 | 7:30AM - 8:00AM
Poster Setup
Room: Saal 4/5


Wednesday, May 11 | 8:00AM - 5:00PM
Poster Viewing
Room: Saal 4/5


Wednesday, May 11 | 8:30AM - 11:30AM
Nucleic Acid Chemistry and Biology in Stress and Innate Immu
ne Response

Room: Saal 4/5

Speaker 1 of 5
Thomas Tuschl, HHMI/Rockefeller University, USA
Intra- and Extracellular Diagnostic RNAseq Approaches and Their Use in Inflammatory Diseases

Wednesday, May 11 | 8:30AM - 11:30AM
Nucleic Acid Chemistry and Biology in Stress and Innate Immu
ne Response

Room: Saal 4/5

Speaker 2 of 5
Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Structure and Function of Innate Immune Sensors and Adaptors

Wednesday, May 11 | 8:30AM - 11:30AM
Nucleic Acid Chemistry and Biology in Stress and Innate Immu
ne Response

Room: Saal 4/5

Speaker 3 of 5
Charles E. Samuel, University of California, Santa Barbara, USA
Roles of A-to-I RNA Editing by Adenosine Deaminase ADAR1 in Innate Immunity RNA Sensing

Wednesday, May 11 | 8:30AM - 11:30AM
Nucleic Acid Chemistry and Biology in Stress and Innate Immu
ne Response

Room: Saal 4/5

Speaker 4 of 5
* Andreas Pichlmair, Max-Planck Institute of Biochemistry, Germany
Defects in mRNA Maturation and Localization

Wednesday, May 11 | 8:30AM - 11:30AM
Nucleic Acid Chemistry and Biology in Stress and Innate Immu
ne Response

Room: Saal 4/5

Speaker 5 of 5
Swapnil Devarkar, Rutgers University, USA
Short Talk: Structural and Mechanistic Basis for Self Versus Non-self RNA Discrimination by the Innate Immune Receptor RIG-I

Wednesday, May 11 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Wednesday, May 11 | 11:30AM - 12:30PM
Lunch
Room: Conference Ctr Restaurant


Wednesday, May 11 | 12:00PM - 2:30PM
Poster Session 3
Room: Saal 4/5


Wednesday, May 11 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, May 11 | 5:00PM - 7:00PM
Nucleic Acid Drug Developments and Strategies to Suppress In
nate Immunity Responses

Room: Saal 4/5

Speaker 1 of 4
Gunther Hartmann, Universitätsklinikum Bonn, Germany
Targeting RIG-I for the Immunotherapy of Cancer

Wednesday, May 11 | 5:00PM - 7:00PM
Nucleic Acid Drug Developments and Strategies to Suppress In
nate Immunity Responses

Room: Saal 4/5

Speaker 2 of 4
Thomas W. Dubensky, Jr., Tempest Therapeutics, USA
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

Wednesday, May 11 | 5:00PM - 7:00PM
Nucleic Acid Drug Developments and Strategies to Suppress In
nate Immunity Responses

Room: Saal 4/5

Speaker 3 of 4
* Regina Heidenreich, CureVac GmbH, Germany
mRNA Vaccination for the Immunotherapy of Infectious Diseases and Cancer

Wednesday, May 11 | 5:00PM - 7:00PM
Nucleic Acid Drug Developments and Strategies to Suppress In
nate Immunity Responses

Room: Saal 4/5

Speaker 4 of 4
Manuel Ascano, Jr., Vanderbilt University, USA
Short Talk: Towards the Small Molecule Modulation of Cyclic GMP-AMP Synthase Activity

Wednesday, May 11 | 7:00PM - 7:00PM
On Own for Dinner


Thursday, May 12 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotels


Thursday, May 12 | 8:30AM - 11:30AM
Inborn Genetic Defects in Nucleic Acid Sensing I
Room: Saal 4/5

Speaker 1 of 5
Raphaela Theresia Goldbach-Mansky, NIAID, National Institutes of Health, USA
Activated STING in a Vascular and Pulmonary Syndrome (SAVI) and Treatment Strategies Reducing Interferon Signaling

Thursday, May 12 | 8:30AM - 11:30AM
Inborn Genetic Defects in Nucleic Acid Sensing I
Room: Saal 4/5

Speaker 2 of 5
Yanick Crow, University of Edinburgh, UK
Human Type I Interferonopathies

Thursday, May 12 | 8:30AM - 11:30AM
Inborn Genetic Defects in Nucleic Acid Sensing I
Room: Saal 4/5

Speaker 3 of 5
Min Ae Lee-Kirsch, Technische Universität Dresden, Germany
Human Genetic Alterations Contributing to Systemic Lupus Erythematosus

Thursday, May 12 | 8:30AM - 11:30AM
Inborn Genetic Defects in Nucleic Acid Sensing I
Room: Saal 4/5

Speaker 4 of 5
* Virginia Pascual, Cornell University, USA
Novel Insights into the Role of Innate Immunity in Human SLE

Thursday, May 12 | 8:30AM - 11:30AM
Inborn Genetic Defects in Nucleic Acid Sensing I
Room: Saal 4/5

Speaker 5 of 5
Rayk Behrendt, Faculty of Medicine Carl Gustav Carus TU Dresden, Germany
Short Talk: SAMHD1-Deficiency causes Simultaneous Stimulation of the RLR and cGAS-STING Pathways

Thursday, May 12 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Thursday, May 12 | 11:30AM - 5:00PM
On Own for Lunch


Thursday, May 12 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, May 12 | 5:00PM - 6:45PM
Inborn Genetic Defects in Nucleic Acid Sensing II
Room: Saal 4/5

Speaker 1 of 3
Gerald S. Shadel, The Salk Institute for Biological Studies, USA
Mitochondrial DNA Stress in Innate Immune Signalling and Cancer

Thursday, May 12 | 5:00PM - 6:45PM
Inborn Genetic Defects in Nucleic Acid Sensing II
Room: Saal 4/5

Speaker 2 of 3
Daniel B. Stetson, University of Washington, USA
Nucleic Acid Detection in Autoimmunity

Thursday, May 12 | 5:00PM - 6:45PM
Inborn Genetic Defects in Nucleic Acid Sensing II
Room: Saal 4/5

Speaker 3 of 3
* Andrew Jackson, University of Edinburgh, UK
RNase H2 mutations Lead to Defective Ribonucleotide Excision Repair and cGAS/STING-Dependent Innate Immune Activation

Thursday, May 12 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Saal 4/5


Thursday, May 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Saal 3
No registration fees are used to fund alcohol served at this function.

Thursday, May 12 | 8:00PM - 11:00PM
Entertainment
Room: Saal 3
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, May 12 | 8:00PM - 11:00PM
Cash Bar
Room: Saal 3


Friday, May 13 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.