Web Desc
Exosomes/Microvesicles: Novel Mechanisms of Cell-Cell Communication
Organizer(s): Richard A. Cerione and Xandra O. Breakefield
Date: June 19 - 22, 2016
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
An emerging area of great excitement in the cell biology and pharmaceutical/biotech communities involves the release and subsequent uptake of membrane-enclosed packets of information, often referred to as extracellular vesicles. These non-traditional vesicles contain a potent array of cargo, including hundreds of proteins such as growth factors and receptors, metabolic enzymes, transcription factors and a large variety of RNA transcripts as well as DNA. Extracellular vesicles span a range of sizes from 50 nm to 1 micron and comprise a heterogenous set, including exosomes and microvesicles that appear to be generated through distinct mechanisms. Extracellular vesicles are thought to serve as a means of cell-to-cell communication and contribute to a number of disease states, including cancer and neurodegeneration, thus offering new targets for therapeutic intervention and novel possibilities for diagnostic biomarkers. However, a number of important questions need to be answered. What are the regulatory cues that determine content and release of these vesicles from ”donor” cells? How many different types of extracellular vesicles are there and do they vary among cell types? Are there specific uptake mechanisms of vesicles into ”recipient cells” and is the cargo functional in these cells? The time is right for a Keystone Symposia meeting that covers this exciting area and aims to bring together investigators from different disciplines and areas of interest to present their newest findings concerning the biogenesis of extracellular vesicles, how they are shed and dock onto target cells, and the biological and disease consequences of their functions.
Scholarship Deadline: February 18 2016
Discounted Abstract Deadline: February 18 2016
Abstract Deadline: March 17 2016
Discounted Registration Deadline: April 19 2016
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Exosome Diagnostics, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA206166-01
Funding for this conference was made possible (in part) by 1R13CA206166-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, June 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Keystone Lodge Lobby


Sunday, June 19 | 6:00PM - 8:00PM
Welcome Mixer
Room: Keystone Lodge-Bighorn Bar
No registration fees are used to fund alcohol served at this function.

Monday, June 20 | 7:30AM - 8:30AM
Breakfast
Room: Crestone


Monday, June 20 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Red Cloud/Shavano

Speaker 1 of 2
* Richard A. Cerione, Cornell University, USA

Monday, June 20 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Red Cloud/Shavano

Speaker 2 of 2
Xandra O. Breakefield, Massachusetts General Hospital, USA
The Language of Extracellular Vesicles

Monday, June 20 | 9:30AM - 12:00PM
Extracellular Vesicles and Cargo
Room: Red Cloud/Shavano

Speaker 1 of 6
Jan Lötvall, University of Gothenburg, Sweden
Extracellular Vesicles and their RNA Cargo

Monday, June 20 | 9:30AM - 12:00PM
Extracellular Vesicles and Cargo
Room: Red Cloud/Shavano


Coffee Break

Monday, June 20 | 9:30AM - 12:00PM
Extracellular Vesicles and Cargo
Room: Red Cloud/Shavano

Speaker 3 of 6
* Louise Laurent, University of California, San Diego, USA
ExRNAs as Biomarkers of Placental Function

Monday, June 20 | 9:30AM - 12:00PM
Extracellular Vesicles and Cargo
Room: Red Cloud/Shavano

Speaker 4 of 6
Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
The Biology and Function of Exosomes in Cancer

Monday, June 20 | 9:30AM - 12:00PM
Extracellular Vesicles and Cargo
Room: Red Cloud/Shavano

Speaker 5 of 6
Jennifer C. Jones, NCI, National Institutes of Health, USA
Short Talk: NanoFACS: A Tool to Enable Extracellular Vesicle Subset Sorting for Personalized Medicine

Monday, June 20 | 9:30AM - 12:00PM
Extracellular Vesicles and Cargo
Room: Red Cloud/Shavano

Speaker 6 of 6
Valery Combes, University of Technology Sydney, Australia
Short Talk: Identification of a Novel Intracellular Actin-Based Structure Implicated in Endothelial Vesiculation

Monday, June 20 | 12:00PM - 5:00PM
On Own for Lunch


Monday, June 20 | 12:00PM - 1:00PM
Poster Setup
Room: Crestone


Monday, June 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone


Monday, June 20 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud/Shavano

Speaker 1 of 8
Chulhee Choi, Korea Advanced Institute of Science and Technology, South Korea
Efficient intra-cellular Delivery of Therapeutic Proteins via Opto-genetically Engineered Exosomes

Monday, June 20 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud/Shavano

Speaker 2 of 8
Deepak Nagrath, University of Michigan, USA
Tumor Microenvironment Derived Exosomes: A Major Player Regulating Cancer Cell Metabolism

Monday, June 20 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud/Shavano

Speaker 3 of 8
Paul Coats, University of Strathclyde, UK
Mitochondrial Regulation of Exosomal MicroRNA Cargo in Vascular Smooth Muscle Cell Proliferation

Monday, June 20 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud/Shavano

Speaker 4 of 8
* Carole A. Parent, NCI, National Institutes of Health, USA
Exosomes as Key Regulators of Signal Relay during Chemotaxis

Monday, June 20 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud/Shavano

Speaker 5 of 8
Ryan Middleton, Cedars-Sinai Medical Center, USA
Newt Exosomes are Bioactive on Mammalian Heart, Enhancing Proliferation of Rat Cardiomyocytes and Improving Recovery after Myocardial Infarction

Monday, June 20 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud/Shavano

Speaker 6 of 8
Anaïs Soula, Interdisciplinary Institute for Neurosciences, France
Involvement of Exosomal miRNAs in the Mechanisms of Neuronal Plasticity

Monday, June 20 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud/Shavano

Speaker 7 of 8
Michela Marcatti, University of Texas Medical Branch, USA
Damaged Mitochondrial DNA as a Potent Inducer of Lung Inflammation

Monday, June 20 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud/Shavano

Speaker 8 of 8
Leonid Margolis, NICHD, National Institutes of Health, USA
Extracellular Vesicles in HIV Infection: Analysis and Function

Monday, June 20 | 4:30PM - 5:00PM
Coffee Available
Room: Crestone Foyer


Monday, June 20 | 5:00PM - 7:00PM
Extracellular Vesicle Biogenesis
Room: Red Cloud/Shavano

Speaker 1 of 4
Guillaume van Niel, Institute Curie, France
Exosomes Shed new Light on Endosomal Sorting and Functional Amyloid Formation

Monday, June 20 | 5:00PM - 7:00PM
Extracellular Vesicle Biogenesis
Room: Red Cloud/Shavano

Speaker 2 of 4
Richard A. Cerione, Cornell University, USA
Signals that Lead to Microvesicle Formation

Monday, June 20 | 5:00PM - 7:00PM
Extracellular Vesicle Biogenesis
Room: Red Cloud/Shavano

Speaker 3 of 4
* Stephen J. Gould, Johns Hopkins University School of Medicine, USA
Exosome Biogenesis: Models, Predictions and Results

Monday, June 20 | 5:00PM - 7:00PM
Extracellular Vesicle Biogenesis
Room: Red Cloud/Shavano

Speaker 4 of 4
Ann M. Wehman, University of Würzburg, Germany
Short Talk: PAD-1 Activates the Phospholipid Flippase TAT-5 to Prevent Extracellular Vesicle Release in C. elegans

Monday, June 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone
No registration fees are used to fund alcohol served at this function.

Monday, June 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Crestone


Tuesday, June 21 | 7:30AM - 8:30AM
Breakfast
Room: Crestone


Tuesday, June 21 | 8:30AM - 11:45AM
Extracellular Vesicle Release and Docking
Room: Red Cloud/Shavano

Speaker 1 of 7
Marc Antonyak, Cornell University, USA
Embryonic Stem Cell Microvesicles and Their Roles in Early Development

Tuesday, June 21 | 8:30AM - 11:45AM
Extracellular Vesicle Release and Docking
Room: Red Cloud/Shavano

Speaker 2 of 7
* Crislyn D'Souza-Schorey, University of Notre Dame, USA
Extracellular Microvesicles Mediate Tumor Cell Invasion

Tuesday, June 21 | 8:30AM - 11:45AM
Extracellular Vesicle Release and Docking
Room: Red Cloud/Shavano


Coffee Break

Tuesday, June 21 | 8:30AM - 11:45AM
Extracellular Vesicle Release and Docking
Room: Red Cloud/Shavano

Speaker 4 of 7
Phyllis I. Hanson, University of Michigan, USA
ESCRTs, Endosomal Trafficking, and Extracellular Vesicle Biogenesis

Tuesday, June 21 | 8:30AM - 11:45AM
Extracellular Vesicle Release and Docking
Room: Red Cloud/Shavano

Speaker 5 of 7
Hakho Lee, Massachusetts General Hospital, USA
Nanotechnology Platforms for Quantitative Analyses of Extracellular Vesicles

Tuesday, June 21 | 8:30AM - 11:45AM
Extracellular Vesicle Release and Docking
Room: Red Cloud/Shavano

Speaker 6 of 7
Andrew R. Nager, Pfizer, USA
Short Talk: Actin-Dependent Ectocytosis and BBSome/beta-Arrestin2-Mediated Retrieval Drive the Removal of Activated GPCRs from Cilia

Tuesday, June 21 | 8:30AM - 11:45AM
Extracellular Vesicle Release and Docking
Room: Red Cloud/Shavano

Speaker 7 of 7
Chungen Pan, Dalhousie University, Canada
Short Talk: Fusogenic Nonenveloped Reoviruses are Released as Highly Infectious Vesicle-Encapsulated Nonenveloped Virus (VENEV) Particles Inside Fusogenic Exosomes

Tuesday, June 21 | 11:45AM - 5:00PM
On Own for Lunch


Tuesday, June 21 | 11:45AM - 1:00PM
Poster Setup
Room: Crestone


Tuesday, June 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone


Tuesday, June 21 | 4:30PM - 5:00PM
Coffee Available
Room: Crestone Foyer


Tuesday, June 21 | 5:00PM - 7:00PM
Extracellular Vesicles as Biomarkers and Therapeutic Vehicle
s

Room: Red Cloud/Shavano

Speaker 1 of 4
* Johan Skog, Exosome Diagnostics, Inc., USA
Exosome Based Liquid Biopsy for Cancer Screening, Patient Stratification and Monitoring

Tuesday, June 21 | 5:00PM - 7:00PM
Extracellular Vesicles as Biomarkers and Therapeutic Vehicle
s

Room: Red Cloud/Shavano

Speaker 2 of 4
Richard Simpson, La Trobe University, Australia
Comparative Proteome and RNA Analyses of Extracellular Vesicle Subtypes

Tuesday, June 21 | 5:00PM - 7:00PM
Extracellular Vesicles as Biomarkers and Therapeutic Vehicle
s

Room: Red Cloud/Shavano

Speaker 3 of 4
Anastasia Khvorova, University of Massachusetts Medical School, USA
Exosomes as Therapeutic RNA Delivery Vehicles

Tuesday, June 21 | 5:00PM - 7:00PM
Extracellular Vesicles as Biomarkers and Therapeutic Vehicle
s

Room: Red Cloud/Shavano

Speaker 4 of 4
Andrew Michael Breglio, NIDCD, National Institutes of Health, USA
Short Talk: Exosomes Protect Inner Ear Hair Cells from Aminoglycoside-Induced Death

Tuesday, June 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone
No registration fees are used to fund alcohol served at this function.

Tuesday, June 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Crestone


Wednesday, June 22 | 7:30AM - 8:30AM
Breakfast
Room: Crestone


Wednesday, June 22 | 8:30AM - 11:45AM
Extracellular Vesicles in Cancer
Room: Red Cloud/Shavano

Speaker 1 of 7
* Janusz Rak, McGill University, Canada
Intercellular Trafficking of Oncogenic Macromolecules as Cargo of Extracellular Vesicles in Cancer – Pathways and Barriers

Wednesday, June 22 | 8:30AM - 11:45AM
Extracellular Vesicles in Cancer
Room: Red Cloud/Shavano

Speaker 2 of 7
Ayuko Hoshino, Weill Cornell Medicine, USA
Tumor Exosome Integrins Initiate Pre-Metastatic Niches

Wednesday, June 22 | 8:30AM - 11:45AM
Extracellular Vesicles in Cancer
Room: Red Cloud/Shavano


Coffee Break

Wednesday, June 22 | 8:30AM - 11:45AM
Extracellular Vesicles in Cancer
Room: Red Cloud/Shavano

Speaker 4 of 7
E. Antonio Chiocca, Brigham and Women's Hospital, USA
Role of Microvesicles in Glioblastoma

Wednesday, June 22 | 8:30AM - 11:45AM
Extracellular Vesicles in Cancer
Room: Red Cloud/Shavano

Speaker 5 of 7
Alissa M. Weaver, Vanderbilt University School of Medicine, USA
Role of Exosomes in Promoting Directional Migration of Cancer Cells

Wednesday, June 22 | 8:30AM - 11:45AM
Extracellular Vesicles in Cancer
Room: Red Cloud/Shavano

Speaker 6 of 7
Sónia A. Melo, i3S Instituto de Investigacao e Inovacao em Saude, Portugal
Short Talk: ExoNet: Exosomes-Mediate Intra-Tumor Communication in Pancreatic Cancer

Wednesday, June 22 | 8:30AM - 11:45AM
Extracellular Vesicles in Cancer
Room: Red Cloud/Shavano

Speaker 7 of 7
Maria Laura Tognoli, University of Oxford, UK
Short Talk: RASSF1C Promotes Tumor Invasiveness via Exosome Release

Wednesday, June 22 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, June 22 | 4:30PM - 5:00PM
Coffee Available
Room: Crestone Foyer


Wednesday, June 22 | 5:00PM - 6:45PM
Extracellular Vesicles in Other Aspects of Biology and Disea
se

Room: Red Cloud/Shavano

Speaker 1 of 4
* Leonid Margolis, NICHD, National Institutes of Health, USA

Wednesday, June 22 | 5:00PM - 6:45PM
Extracellular Vesicles in Other Aspects of Biology and Disea
se

Room: Red Cloud/Shavano

Speaker 2 of 4
Mercedes Tkach, Institut Curie, France
Extracellular Vesicles in Immune Response

Wednesday, June 22 | 5:00PM - 6:45PM
Extracellular Vesicles in Other Aspects of Biology and Disea
se

Room: Red Cloud/Shavano

Speaker 3 of 4
Kaushik Choudhuri, University of Michigan Medical School, USA
Microvesicle Release in T Cell Communication

Wednesday, June 22 | 5:00PM - 6:45PM
Extracellular Vesicles in Other Aspects of Biology and Disea
se

Room: Red Cloud/Shavano

Speaker 4 of 4
Andrew Hill, La Trobe University, Australia
Role of Extracellular Vesicles in Neurodegenerative Diseases

Wednesday, June 22 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Red Cloud/Shavano

Speaker 1 of 2
Richard A. Cerione, Cornell University, USA

Wednesday, June 22 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Red Cloud/Shavano

Speaker 2 of 2
Xandra O. Breakefield, Massachusetts General Hospital, USA

Wednesday, June 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone
No registration fees are used to fund alcohol served at this function.

Wednesday, June 22 | 8:00PM - 11:00PM
Entertainment
Room: Crestone
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Wednesday, June 22 | 8:00PM - 11:00PM
Cash Bar
Room: Crestone


Thursday, June 23 | 10:25AM - 10:25AM
Departure


*Session Chair.