Web Desc
Nuclear Receptors: Full Throttle
joint with Metabolism, Transcription and Disease
Organizer(s): Carol A. Lange, Jennifer K. Richer and Karen E. Knudsen
Date: January 10 - 14, 2016
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by Intercept Pharmaceuticals, Inc.
Summary of Meeting:
Nuclear receptors (NRs) represent a large superfamily of ligand-dependent transcription factor “sensors” for a diverse set of fat-soluble hormones, vitamins and dietary lipids. NRs orchestrate genetic response programs critical for normal homeostasis, and are required for reproduction, development, metabolism and immune function. For this reason, NRs have been investigated for over 30 years as promising targets for drugs to treat a broad spectrum of diseases including cancer, diabetes and other endocrine or metabolic disorders, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. Research on NRs has led to numerous successful therapies for deadly diseases that have improved both longevity and quality of life. However, significant hurdles remain that involve further detailed understanding of the major gene regulatory networks regulated by NRs, how these differ in normal relative to pre-disease and disease states, and the complex problems associated with targeting tissue-specific effects (to reduce side effects) and circumventing mechanisms of resistance. Thus, further insight into the full range of NR functions and interactions with co-regulatory molecules and signaling pathways is necessary for combinatorial approaches involving NRs in health and disease, and development of next-generation therapies. This meeting on “Nuclear Receptors: Full Throttle” continues the Keystone Symposia tradition of bringing together a diverse array of our leading scientists, including senior and junior investigators and their trainees, from academic, clinical and pharmaceutical settings, to showcase the latest science, highlight the use of innovative and emerging technologies, explore new directions, and develop collaborative and synergistic efforts in the exciting field of NR biology.
Scholarship Deadline: September 23 2015
Discounted Abstract Deadline: September 23 2015
Abstract Deadline: October 22 2015
Discounted Registration Deadline: November 12 2015
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Intercept Pharmaceuticals, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA200226-01
Funding for this conference was made possible (in part) by 1R13CA200226-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 10 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Sunday, January 10 | 6:00PM - 8:00PM
Welcome Mixer
Room: Ballroom Lobby
No registration fees are used to fund alcohol served at this function.

Monday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, January 11 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Ballroom 1-3

Speaker 1 of 3
* Carol A. Lange, University of Minnesota, USA

Monday, January 11 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Ballroom 1-3

Speaker 2 of 3
* Peter Verrijzer, Erasmus University Medical Center, Netherlands

Monday, January 11 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Ballroom 1-3

Speaker 3 of 3
Robert T. Tjian, HHMI/University of California, Berkeley, USA
Probing Transcription Regulation by Single Molecule Imaging

Monday, January 11 | 9:00AM - 11:30AM
Transcription and Human Disease (Joint)
Room: Ballroom 1-3

Speaker 1 of 4
Danny F. Reinberg, HHMI/New York University, USA
Epigenetic Regulation by Polycomb Complexes

Monday, January 11 | 9:00AM - 11:30AM
Transcription and Human Disease (Joint)
Room: Ballroom 1-3

Speaker 2 of 4
Susanne Mandrup, University of Southern Denmark, Denmark
Reorganization of the 3D Chromatin Structure during Adipocyte Differentiation

Monday, January 11 | 9:00AM - 11:30AM
Transcription and Human Disease (Joint)
Room: Ballroom 1-3

Speaker 3 of 4
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Nuclear Receptors and the Transcriptional Regulation of Circadian Rhythms and Metabolism

Monday, January 11 | 9:00AM - 11:30AM
Transcription and Human Disease (Joint)
Room: Ballroom 1-3

Speaker 4 of 4
Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany
Epigenetic Regulation by MOF Containing Complexes

Monday, January 11 | 9:40AM - 10:00AM
Coffee Break
Room: Ballroom Lobby


Monday, January 11 | 11:30AM - 1:00PM
Poster Setup
Room: Primrose


Monday, January 11 | 11:30AM - 2:30PM
On Own for Lunch


Monday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 1 of 9
* Carolyn L. Smith, Baylor College of Medicine, USA

Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 2 of 9
Sofie Johanna Desmet, Ghent University/VIB, Belgium
Cofactor Profiling Following Selective Modulation of the Glucocorticoid Receptor

Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 3 of 9
Jay Gertz, University of Utah, USA
Functional Dissection of Estrogen Receptor Alpha Bound Enhancers at their Endogenous Loci

Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 4 of 9
Ville Paakinaho, National Institutes of Health, USA
Single-Molecule Analysis of Glucocorticoid Receptor and Cofactor Action in Living Cells

Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 5 of 9
Jing Yang, Baylor College of Medicine, USA
The Histone Demethylase PHF8, a Novel Interacting Partner of the SMRT Coregulator, Promotes Estrogen Receptor-alpha Transcriptional Activity

Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 6 of 9
Dinny Graham, Westmead Institute for Medical Research, University of Sydney, Australia
Differential Effects of Cell Type and Nuclear Environment on Progesterone Receptor Isoform Function

Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 7 of 9
Coralie Poulard, University of Southern California, USA
Crosstalk between Automethylation and Phosphorylation Tightly Regulates G9a Coactivator Function with Steroid Hormone Receptors

Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 8 of 9
Bart Kolendowski, University of Western Ontario, Canada
The Role of Thymine DNA Glycosylase (TDG) in Estrogen Receptor Signalling and Enhancer RNA Regulation in Breast Cancer

Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 9 of 9
Sean W. Fanning, University of Chicago, USA
Bazedoxifene Potently Inhibits Y537S and D538G ESR1 Somatic Mutants by Disrupting the Constitutively Active AF-2 Conformational State

Monday, January 11 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, January 11 | 5:00PM - 7:00PM
Co-Regulators
Room: Ballroom 2-3

Speaker 1 of 5
* Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA

Monday, January 11 | 5:00PM - 7:00PM
Co-Regulators
Room: Ballroom 2-3

Speaker 2 of 5
Myles Brown, Dana-Farber Cancer Institute, USA
Hacking the Steroid Receptor Cistrome

Monday, January 11 | 5:00PM - 7:00PM
Co-Regulators
Room: Ballroom 2-3

Speaker 3 of 5
Qianben Wang, Duke University School of Medicine, USA
Precise and Dynamic Definition of Nuclear Receptor Collaborator and Coregulator Cistromes

Monday, January 11 | 5:00PM - 7:00PM
Co-Regulators
Room: Ballroom 2-3

Speaker 4 of 5
Carol A. Lange, University of Minnesota, USA
Stress-Responsive Gene Regulation by GR/HIF/PELP1 Complexes in Triple-Negative Breast Cancer

Monday, January 11 | 5:00PM - 7:00PM
Co-Regulators
Room: Ballroom 2-3

Speaker 5 of 5
Timothy E. Reddy, Duke University, USA
Short Talk: Massively Parallel Reporter Assays Reveal Glucocorticoid Receptor Interaction Modules that Direct Gene Expression Responses to Corticosteroids

Monday, January 11 | 5:00PM - 7:00PM
Epigenetics and Chromatin as a Metabolic Sensor
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 1 of 5
* Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany


Monday, January 11 | 5:00PM - 7:00PM
Epigenetics and Chromatin as a Metabolic Sensor
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 2 of 5
Hans-Martin Herz, St. Jude Children's Research Hospital, USA
Short Talk: The Histone H3 Lysine 4 to Methionine (H3K4M) Mutant as a Tool to Study Enhancer-Mediated Processes


Monday, January 11 | 5:00PM - 7:00PM
Epigenetics and Chromatin as a Metabolic Sensor
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 3 of 5
Katrin F. Chua, Stanford University Medical Center, USA
Chromatin Regulation and Genome Maintenance by Mammalian Sirtuins


Monday, January 11 | 5:00PM - 7:00PM
Epigenetics and Chromatin as a Metabolic Sensor
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 4 of 5
Tokameh Mahmoudi, Erasmus Universiteit Rotterdam, Netherlands
Signaling to Chromatin and Viral Latency


Monday, January 11 | 5:00PM - 7:00PM
Epigenetics and Chromatin as a Metabolic Sensor
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 5 of 5
Melanie M. Ott, Gladstone Institutes, USA
Metabolic Reprogramming of T Cells by SIRT1


Monday, January 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Monday, January 11 | 7:30PM - 10:00PM
Poster Session 1
Room: Primrose


Tuesday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
Room: Ballroom 2-3

Speaker 1 of 7
* Scott M. Dehm, University of Minnesota, USA

Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
Room: Ballroom 2-3

Speaker 2 of 7
Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
Nuclear Receptor-DNA Repair Crosstalk: Bench to Bedside

Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
Room: Ballroom 2-3

Speaker 3 of 7
John A. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA
Novel Ligands for Estrogen Receptor and Androgen Receptor Targeted Therapies

Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
Room: Ballroom 2-3

Speaker 4 of 7
Susan K. Logan, New York University School of Medicine, USA
Transcription Repression in Prostate Cancer

Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
Room: Ballroom 2-3

Speaker 5 of 7
Amy Peterson, BeiGene, USA
Advances in the Use of Selective Androgen Receptor Modulators as Cancer Therapies

Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
Room: Ballroom 2-3

Speaker 6 of 7
Yiru Chen Zhao, University of Illinois at Urbana-Champaign, USA
Short Talk: Prevention of Obesity Related Breast Cancer Using Pathway Preferential Estrogens

Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
Room: Ballroom 2-3

Speaker 7 of 7
Lisa Greene, University of Colorado Anschutz Medical Campus, USA
Short Talk: Suppression of CD8 T-cells by Tryptophan Catabolism in Triple-Negative Breast Cancer

Tuesday, January 12 | 8:00AM - 11:15AM
Signaling to Chromatin and Human Disease
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 1 of 6
Gerald R. Crabtree, Stanford University, USA
ATP-Dependent Chromatin Remodeling: Insights from New Methods and the Genomics of Human Disease


Tuesday, January 12 | 8:00AM - 11:15AM
Signaling to Chromatin and Human Disease
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 2 of 6
Irina M. Bochkis, University of Virginia, USA
Short Talk: Reorganization of Lamina-Associated Domains in Aged Liver Alters Binding of Pioneer Factor Foxa2


Tuesday, January 12 | 8:00AM - 11:15AM
Signaling to Chromatin and Human Disease
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 3 of 6
* Jerry L. Workman, Stowers Institute for Medical Research, USA
Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism


Tuesday, January 12 | 8:00AM - 11:15AM
Signaling to Chromatin and Human Disease
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 4 of 6
W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Nuclear NAD+ Signaling through DNA-dependent PARPs and the Control of Gene Expression


Tuesday, January 12 | 8:00AM - 11:15AM
Signaling to Chromatin and Human Disease
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 5 of 6
Juan Du, Beckman Research Institute of City of Hope, USA
Short Talk: Chromatin Variation Driven by Transposable Elements Is a Key Contributor to Liver Metabolism in Mice


Tuesday, January 12 | 8:00AM - 11:15AM
Signaling to Chromatin and Human Disease
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 6 of 6
Ali Shilatifard, Northwestern University, USA
Enhancer Malfunction in Cancer


Tuesday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, January 12 | 11:15AM - 1:00PM
Poster Setup
Room: Primrose


Tuesday, January 12 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, January 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Tuesday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, January 12 | 5:00PM - 7:00PM
Advances in Structures, Ligands and Energetics
Room: Ballroom 2-3

Speaker 1 of 5
* Myles Brown, Dana-Farber Cancer Institute, USA

Tuesday, January 12 | 5:00PM - 7:00PM
Advances in Structures, Ligands and Energetics
Room: Ballroom 2-3

Speaker 2 of 5
Nima Sharifi, Cleveland Clinic, USA
Feeding the Ligand Addiction in Advanced Cancers

Tuesday, January 12 | 5:00PM - 7:00PM
Advances in Structures, Ligands and Energetics
Room: Ballroom 2-3

Speaker 3 of 5
Kendall W. Nettles, The Scripps Research Institute, USA
Predicting Phenotypic Outcomes for Estrogen Receptor Ligands

Tuesday, January 12 | 5:00PM - 7:00PM
Advances in Structures, Ligands and Energetics
Room: Ballroom 2-3

Speaker 4 of 5
David L. Bain, University of Colorado Anschutz Medical Campus, USA
Nuclear Receptor Functional Energetics and Transcriptional Regulation

Tuesday, January 12 | 5:00PM - 7:00PM
Advances in Structures, Ligands and Energetics
Room: Ballroom 2-3

Speaker 5 of 5
Kerry Kornfeld, Washington University Medical School, USA
Short Talk: The Nuclear Receptor HIZR-1 Mediates Zinc Homeostasis by Functioning as a Zinc Sensor and Transcription Response Effector

Tuesday, January 12 | 5:00PM - 7:00PM
Metabolism and Gene Control
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 1 of 5
* Melanie M. Ott, Gladstone Institutes, USA


Tuesday, January 12 | 5:00PM - 7:00PM
Metabolism and Gene Control
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 2 of 5
Jesper Q. Svejstrup, Francis Crick Institute, UK
Transcription-Associated Genome Instability


Tuesday, January 12 | 5:00PM - 7:00PM
Metabolism and Gene Control
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 3 of 5
Frances M. Sladek, University of California, Riverside, USA
Short Talk: Soybean Oil Induces Obesity via Linoleic Acid, Oxylipins and Nuclear Receptor HNF4alpha


Tuesday, January 12 | 5:00PM - 7:00PM
Metabolism and Gene Control
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 4 of 5
Katherine A. Jones, The Salk Institute, USA
Metabolic Role for CTD Kinases


Tuesday, January 12 | 5:00PM - 7:00PM
Metabolism and Gene Control
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 5 of 5
Joaquín M. Espinosa, Linda Crnic Institute for Down Syndrome, USA
Mechanisms of Transcriptional Control by HIF1 and its Cofactors in Response to Hypoxia


Tuesday, January 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Tuesday, January 12 | 7:30PM - 10:00PM
Poster Session 2
Room: Primrose


Wednesday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s

Room: Ballroom 2-3

Speaker 1 of 7
* Kenneth S. Korach, NIEHS, National Institutes of Health, USA

Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s

Room: Ballroom 2-3

Speaker 2 of 7
Ellis R. Levin, University of California, Irvine, USA
Membrane and Nuclear-Only ERalpha Mice Inform Phenotypes and Metabolic Functions Resulting from Estrogen Action

Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s

Room: Ballroom 2-3

Speaker 3 of 7
Cheryl L. Walker, Baylor College of Medicine, USA
Environmental Estrogens Activate Nongenomic ER Signaling to Developmentally Reprogram the Epigenome

Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s

Room: Ballroom 2-3

Speaker 4 of 7
Stephen R. Hammes, University of Rochester Medical Center, USA
Crosstalk between Estrogen and mTOR Signaling in Lymphangioleiomyomatosis (LAM)

Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s

Room: Ballroom 2-3

Speaker 5 of 7
Zeynep Madak-Erdogan, University of Illinois at Urbana-Champaign, USA
Systems Biology of Gene and Metabolic Regulation by Estrogen Receptors and Kinases in Breast Cancer and Metabolic Disease

Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s

Room: Ballroom 2-3

Speaker 6 of 7
Rebecca B. Riggins, Georgetown University, USA
Short Talk: The Extra-Nuclear Life of ERRbeta2: Cytoskeletal and Mitotic Functions of an Orphan Nuclear Receptor Splice Variant

Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s

Room: Ballroom 2-3

Speaker 7 of 7
Andrea R. Patterson, Ohio State University, USA
Short Talk: The Role of Stromal Estrogen Receptor in Mammary Gland Reprogramming Following in Utero BPA Exposure

Wednesday, January 13 | 8:00AM - 11:00AM
Metabolism and Tumor Suppression
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 1 of 6
* Jane Mellor, University of Oxford, UK


Wednesday, January 13 | 8:00AM - 11:00AM
Metabolism and Tumor Suppression
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 2 of 6
Jennifer Jones McCann, Thomas Jefferson University, USA
Short Talk: Novel Action of p53 Gain-of-Function Mutations in Prostate Cancer Progression


Wednesday, January 13 | 8:00AM - 11:00AM
Metabolism and Tumor Suppression
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 3 of 6
Amanda G. Fisher, Imperial College London, UK
Non-Invasive Imaging of Epigenetic Changes in the Developing Embryo


Wednesday, January 13 | 8:00AM - 11:00AM
Metabolism and Tumor Suppression
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 4 of 6
Adrian P. Bracken, Trinity College Dublin, Ireland
The PRC2 Complex in Cellular Proliferation and Cancer


Wednesday, January 13 | 8:00AM - 11:00AM
Metabolism and Tumor Suppression
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 5 of 6
Selma Masri, University of California, Irvine, USA
Short Talk: Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis


Wednesday, January 13 | 8:00AM - 11:00AM
Metabolism and Tumor Suppression
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 6 of 6
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Metabolic Regulation of Epigenetics


Wednesday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Wednesday, January 13 | 11:15AM - 1:00PM
Poster Setup
Room: Primrose


Wednesday, January 13 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Wednesday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, January 13 | 5:00PM - 7:00PM
Circadian and Metabolic Cycles (Joint)
Room: Ballroom 1-3

Speaker 1 of 5
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Wednesday, January 13 | 5:00PM - 7:00PM
Circadian and Metabolic Cycles (Joint)
Room: Ballroom 1-3

Speaker 2 of 5
Ronald M. Evans, HHMI/The Salk Institute, USA
Nuclear Receptors—Physiology's Architect: A 30 Year Perspective

Wednesday, January 13 | 5:00PM - 7:00PM
Circadian and Metabolic Cycles (Joint)
Room: Ballroom 1-3

Speaker 3 of 5
Paolo Sassone-Corsi, University of California, Irvine, USA
Metabolic and Epigenetic Language of the Circadian Clock

Wednesday, January 13 | 5:00PM - 7:00PM
Circadian and Metabolic Cycles (Joint)
Room: Ballroom 1-3

Speaker 4 of 5
Jane Mellor, University of Oxford, UK
Transcriptional Regulation of the Metabolic Cycle

Wednesday, January 13 | 5:00PM - 7:00PM
Circadian and Metabolic Cycles (Joint)
Room: Ballroom 1-3

Speaker 5 of 5
Ronald M. Evans, HHMI/The Salk Institute, USA
Nuclear Receptors and the Circadian Clock

Wednesday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Wednesday, January 13 | 7:30PM - 10:00PM
Poster Session 3
Room: Primrose


Thursday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es

Room: Ballroom 2-3

Speaker 1 of 7
* Jonna Frasor, University of Illinois, Chicago, USA

Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es

Room: Ballroom 2-3

Speaker 2 of 7
Christine Louise Clarke, Westmead Millennium Institute, Australia
Progesterone Action in Normal Breast and Breast Cancer

Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es

Room: Ballroom 2-3

Speaker 3 of 7
Gail S. Prins, University of Illinois, USA
Estrogenic Regulation of Prostate Stem and Progenitor Cells: Differential Actions through ERalpha and ERbeta

Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es

Room: Ballroom 2-3

Speaker 4 of 7
Jennifer K. Richer, University of Colorado Anschutz Medical Campus, USA
Subtype-Specific AR Action in Breast Cancer

Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es

Room: Ballroom 2-3

Speaker 5 of 7
John A. Cidlowski, NIEHS, National Institutes of Health, USA
Stress Hormone Signaling and Heart Disease: The Good, the Bad, and the Deadly

Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es

Room: Ballroom 2-3

Speaker 6 of 7
Diana M. Cittelly, University of Colorado Anschutz Medical Campus, USA
Short Talk: Ovarian and Brain Estrogens Promote Brain Metastases of Triple-Negative Breast Cancer

Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es

Room: Ballroom 2-3

Speaker 7 of 7
Christopher M. McNair, Thomas Jefferson University, USA
Short Talk: RB Loss Re-Programs E2F1 and AR Cistromes in Prostate Cancer

Thursday, January 14 | 9:00AM - 11:15AM
Obesity, Diabetes and Misregulation of Gene Expression
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 1 of 5
* Paolo Sassone-Corsi, University of California, Irvine, USA


Thursday, January 14 | 9:00AM - 11:15AM
Obesity, Diabetes and Misregulation of Gene Expression
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 2 of 5
Amandine Chaix, The Salk Institute for Biological Studies, USA
Short Talk: Time-Restricted Feeding is a Preventative and Therapeutic Intervention Against Diverse Nutritional Challenges


Thursday, January 14 | 9:00AM - 11:15AM
Obesity, Diabetes and Misregulation of Gene Expression
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 3 of 5
Carl S. Thummel, University of Utah School of Medicine, USA
Regulation of Mitochondrial Transcription and Carbohydrate Homeostasis by the HNF4 Nuclear Receptor


Thursday, January 14 | 9:00AM - 11:15AM
Obesity, Diabetes and Misregulation of Gene Expression
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 4 of 5
Shingo Kajimura, Harvard Medical School, Beth Israel Deaconess Medical Center, USA
Molecular Basis of Beige Adipocyte Maintenance and Energy Expenditure


Thursday, January 14 | 9:00AM - 11:15AM
Obesity, Diabetes and Misregulation of Gene Expression
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 5 of 5
Anders M. Näär, University of California, Berkeley, USA
Transcriptional and MicroRNA Circuits in Metabolic Disorder


Thursday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Thursday, January 14 | 11:15AM - 2:30PM
On Own for Lunch


Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
Room: Ballroom 2-3

Speaker 1 of 8
* Carol A. Lange, University of Minnesota, USA

Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
Room: Ballroom 2-3

Speaker 2 of 8
Christy Hagan, University of Kansas Medical Center, USA
Progesterone Receptor Promotes Inflammatory Gene Programs in Breast Cancer

Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
Room: Ballroom 2-3

Speaker 3 of 8
Lynsey M. Fettig, University of Colorado, USA
Progesterone Receptor-Retinoic Acid Receptor Crosstalk in Regulating a Breast Cancer Stem Cell Population

Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
Room: Ballroom 2-3

Speaker 4 of 8
Michael A. Gordon, University of Colorado Anschutz Medical Campus, USA
Targeting Multiple Pathways in Breast Cancer: Androgen Receptor, HER2, and mTOR

Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
Room: Ballroom 2-3

Speaker 5 of 8
Daniel E. Frigo, University of Houston, USA
Regulation of AMPK by Androgen Receptor Signaling and its Role in Prostate Cancer Metabolism

Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
Room: Ballroom 2-3

Speaker 6 of 8
Zhenqi Zhou, University of California, Los Angeles, USA
ERalpha Deficiency-Induced Mitochondrial Dysfunction and Skeletal Muscle Insulin Resistance is Mediated by Imbalanced Fission-Fusion Dynamics in Females

Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
Room: Ballroom 2-3

Speaker 7 of 8
Hari Singhal, University of Chicago, USA
Progesterone Receptor Agonists, Antagonists and Isoforms Differentially Reprogram Estrogen Signaling in Breast Cancer

Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
Room: Ballroom 2-3

Speaker 8 of 8
Nancy R. Gough, National Breast Cancer Coalition, USA
Presentation on Science Writing

Thursday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, January 14 | 5:00PM - 6:00PM
NRs as Modulators of Immune Cell Function
Room: Ballroom 2-3

Speaker 1 of 3
* Jennifer K. Richer, University of Colorado Anschutz Medical Campus, USA

Thursday, January 14 | 5:00PM - 6:00PM
NRs as Modulators of Immune Cell Function
Room: Ballroom 2-3

Speaker 2 of 3
Inez Rogatsky, Weill Medical College of Cornell University, USA
Transcriptional Cofactor NCoA2/GRIP1 in Macrophage Polarization and Metabolic Control

Thursday, January 14 | 5:00PM - 6:00PM
NRs as Modulators of Immune Cell Function
Room: Ballroom 2-3

Speaker 3 of 3
Christopher K. Glass, University of California, San Diego, USA
Influence of Tissue Environment on Macrophage Identity and Function

Thursday, January 14 | 5:00PM - 7:00PM
Transcriptional Control of Cell Growth
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 1 of 5
* Katherine A. Jones, The Salk Institute, USA


Thursday, January 14 | 5:00PM - 7:00PM
Transcriptional Control of Cell Growth
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 2 of 5
James T. Kadonaga, University of California, San Diego, USA
Operating Systems, Apps, and Novel Chromatin Structures for the Regulation of Our Genes


Thursday, January 14 | 5:00PM - 7:00PM
Transcriptional Control of Cell Growth
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 3 of 5
Claudio J. Villanueva, University of California, Los Angeles, USA
Short Talk: TLE3 is a Gatekeeper of the Beige Transcriptional Program


Thursday, January 14 | 5:00PM - 7:00PM
Transcriptional Control of Cell Growth
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 4 of 5
Don Ayer, University of Utah, USA
c-Myc and MondoA Couple Nutrient Utilization and Availability in Tumorigenesis


Thursday, January 14 | 5:00PM - 7:00PM
Transcriptional Control of Cell Growth
This session is from Metabolism, Transcription
Room: Ballroom 1

Speaker 5 of 5
Peter Verrijzer, Erasmus University Medical Center, Netherlands
Transcription Control by Nucleotide Biosynthetic Enzymes


Thursday, January 14 | 6:00PM - 6:45PM
Closing Keynote Address
Room: Ballroom 2-3

Speaker 1 of 1
Joe Thornton, University of Chicago, USA
Nuclear Receptor Evolution: How NR Structures and Functions Came to Be

Thursday, January 14 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Ballroom 2-3


Thursday, January 14 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Ballroom 2-3
No registration fees are used to fund alcohol served at this function.

Thursday, January 14 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2-3
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 14 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 2-3


Friday, January 15 | 10:25AM - 10:25AM
Departure


*Session Chair.