Web Desc
Metabolism, Transcription and Disease
joint with Nuclear Receptors: Full Throttle
Organizer(s): Peter Verrijzer, Katherine A. Jones and Paolo Sassone-Corsi
Date: January 10 - 14, 2016
Location: Snowbird Resort, Snowbird, UT, USA
Supported by the Directors' Fund
Summary of Meeting:
To maintain homeostasis, cells need to coordinate gene expression and metabolic state. There is increasing evidence that misregulation of metabolic flux and gene transcription plays a major role in human diseases, including obesity, diabetes and cancer. The aim of this meeting is to explore how metabolic state influences gene expression programs and, conversely, how intermediary metabolism is controlled by the transcription machinery and chromatin-modulating enzymes. Particular emphasis will be on the connection between gene transcription and metabolism in homeostatic and diseased state. Emerging evidence emphasizes that chromatin-modifying enzymes depend on substrates, or co-factors, that are key components of intermediary metabolism. The cellular concentration of these metabolites fluctuates in response to, for example, nutrient availability, circadian cycles or oncogenic transformation. Thus, chromatin might be considered a sensor of metabolic state. Moreover, some metabolic enzymes play surprisingly direct roles in transcription control. Conversely, transcriptional control of metabolic enzyme expression, for example by nuclear receptors or the oncogene Myc, plays a major role in maintaining homeostasis, circadian rhythm or driving cell growth and proliferation. The aim of this Keystone Symposia meeting is to bring together scientists working on basic aspects of transcription control, epigenetics, metabolic disease and cancer. The meeting should serve as a discussion platform to explore the rapidly growing interphase between transcription regulation, metabolic reprogramming and human disease.
Scholarship Deadline: September 23 2015
Discounted Abstract Deadline: September 23 2015
Abstract Deadline: October 22 2015
Discounted Registration Deadline: November 12 2015
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK107250-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 10 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Sunday, January 10 | 6:00PM - 8:00PM
Welcome Mixer
Room: Ballroom Lobby
No registration fees are used to fund alcohol served at this function.

Monday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, January 11 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Ballroom 1-3

Speaker 1 of 3
* Carol A. Lange, University of Minnesota, USA

Monday, January 11 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Ballroom 1-3

Speaker 2 of 3
* Peter Verrijzer, Erasmus University Medical Center, Netherlands

Monday, January 11 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Ballroom 1-3

Speaker 3 of 3
Robert T. Tjian, HHMI/University of California, Berkeley, USA
Probing Transcription Regulation by Single Molecule Imaging

Monday, January 11 | 9:00AM - 11:30AM
Transcription and Human Disease (Joint)
Room: Ballroom 1-3

Speaker 1 of 4
Danny F. Reinberg, HHMI/New York University, USA
Epigenetic Regulation by Polycomb Complexes

Monday, January 11 | 9:00AM - 11:30AM
Transcription and Human Disease (Joint)
Room: Ballroom 1-3

Speaker 2 of 4
Susanne Mandrup, University of Southern Denmark, Denmark
Reorganization of the 3D Chromatin Structure during Adipocyte Differentiation

Monday, January 11 | 9:00AM - 11:30AM
Transcription and Human Disease (Joint)
Room: Ballroom 1-3

Speaker 3 of 4
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Nuclear Receptors and the Transcriptional Regulation of Circadian Rhythms and Metabolism

Monday, January 11 | 9:00AM - 11:30AM
Transcription and Human Disease (Joint)
Room: Ballroom 1-3

Speaker 4 of 4
Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany
Epigenetic Regulation by MOF Containing Complexes

Monday, January 11 | 9:40AM - 10:00AM
Coffee Break
Room: Ballroom Lobby


Monday, January 11 | 11:30AM - 1:00PM
Poster Setup
Room: Primrose


Monday, January 11 | 11:30AM - 5:00PM
On Own for Lunch


Monday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
This session is from Nuclear Receptors
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 1 of 9
* Carolyn L. Smith, Baylor College of Medicine, USA


Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
This session is from Nuclear Receptors
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 2 of 9
Sofie Johanna Desmet, Ghent University/VIB, Belgium
Cofactor Profiling Following Selective Modulation of the Glucocorticoid Receptor


Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
This session is from Nuclear Receptors
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 3 of 9
Jay Gertz, University of Utah, USA
Functional Dissection of Estrogen Receptor Alpha Bound Enhancers at their Endogenous Loci


Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
This session is from Nuclear Receptors
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 4 of 9
Ville Paakinaho, National Institutes of Health, USA
Single-Molecule Analysis of Glucocorticoid Receptor and Cofactor Action in Living Cells


Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
This session is from Nuclear Receptors
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 5 of 9
Jing Yang, Baylor College of Medicine, USA
The Histone Demethylase PHF8, a Novel Interacting Partner of the SMRT Coregulator, Promotes Estrogen Receptor-alpha Transcriptional Activity


Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
This session is from Nuclear Receptors
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 6 of 9
Dinny Graham, Westmead Institute for Medical Research, University of Sydney, Australia
Differential Effects of Cell Type and Nuclear Environment on Progesterone Receptor Isoform Function


Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
This session is from Nuclear Receptors
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 7 of 9
Coralie Poulard, University of Southern California, USA
Crosstalk between Automethylation and Phosphorylation Tightly Regulates G9a Coactivator Function with Steroid Hormone Receptors


Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
This session is from Nuclear Receptors
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 8 of 9
Bart Kolendowski, University of Western Ontario, Canada
The Role of Thymine DNA Glycosylase (TDG) in Estrogen Receptor Signalling and Enhancer RNA Regulation in Breast Cancer


Monday, January 11 | 2:30PM - 4:30PM
Workshop 1: NR Interactions with DNA and the Transcriptional
Machinery
This session is from Nuclear Receptors
Room: Ballroom 2-3
NR Interactions with DNA & the Transcriptional Machinery
Speaker 9 of 9
Sean W. Fanning, University of Chicago, USA
Bazedoxifene Potently Inhibits Y537S and D538G ESR1 Somatic Mutants by Disrupting the Constitutively Active AF-2 Conformational State


Monday, January 11 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, January 11 | 5:00PM - 7:00PM
Epigenetics and Chromatin as a Metabolic Sensor
Room: Ballroom 1

Speaker 1 of 5
* Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany

Monday, January 11 | 5:00PM - 7:00PM
Epigenetics and Chromatin as a Metabolic Sensor
Room: Ballroom 1

Speaker 2 of 5
Hans-Martin Herz, St. Jude Children's Research Hospital, USA
Short Talk: The Histone H3 Lysine 4 to Methionine (H3K4M) Mutant as a Tool to Study Enhancer-Mediated Processes

Monday, January 11 | 5:00PM - 7:00PM
Epigenetics and Chromatin as a Metabolic Sensor
Room: Ballroom 1

Speaker 3 of 5
Katrin F. Chua, Stanford University Medical Center, USA
Chromatin Regulation and Genome Maintenance by Mammalian Sirtuins

Monday, January 11 | 5:00PM - 7:00PM
Epigenetics and Chromatin as a Metabolic Sensor
Room: Ballroom 1

Speaker 4 of 5
Tokameh Mahmoudi, Erasmus Universiteit Rotterdam, Netherlands
Signaling to Chromatin and Viral Latency

Monday, January 11 | 5:00PM - 7:00PM
Epigenetics and Chromatin as a Metabolic Sensor
Room: Ballroom 1

Speaker 5 of 5
Melanie M. Ott, Gladstone Institutes, USA
Metabolic Reprogramming of T Cells by SIRT1

Monday, January 11 | 5:00PM - 7:00PM
Co-Regulators
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 1 of 5
* Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA


Monday, January 11 | 5:00PM - 7:00PM
Co-Regulators
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 2 of 5
Myles Brown, Dana-Farber Cancer Institute, USA
Hacking the Steroid Receptor Cistrome


Monday, January 11 | 5:00PM - 7:00PM
Co-Regulators
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 3 of 5
Qianben Wang, Duke University School of Medicine, USA
Precise and Dynamic Definition of Nuclear Receptor Collaborator and Coregulator Cistromes


Monday, January 11 | 5:00PM - 7:00PM
Co-Regulators
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 4 of 5
Carol A. Lange, University of Minnesota, USA
Stress-Responsive Gene Regulation by GR/HIF/PELP1 Complexes in Triple-Negative Breast Cancer


Monday, January 11 | 5:00PM - 7:00PM
Co-Regulators
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 5 of 5
Timothy E. Reddy, Duke University, USA
Short Talk: Massively Parallel Reporter Assays Reveal Glucocorticoid Receptor Interaction Modules that Direct Gene Expression Responses to Corticosteroids


Monday, January 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Monday, January 11 | 7:30PM - 10:00PM
Poster Session 1
Room: Primrose


Tuesday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, January 12 | 8:00AM - 11:15AM
Signaling to Chromatin and Human Disease
Room: Ballroom 1

Speaker 1 of 6
Gerald R. Crabtree, Stanford University, USA
ATP-Dependent Chromatin Remodeling: Insights from New Methods and the Genomics of Human Disease

Tuesday, January 12 | 8:00AM - 11:15AM
Signaling to Chromatin and Human Disease
Room: Ballroom 1

Speaker 2 of 6
Irina M. Bochkis, University of Virginia, USA
Short Talk: Reorganization of Lamina-Associated Domains in Aged Liver Alters Binding of Pioneer Factor Foxa2

Tuesday, January 12 | 8:00AM - 11:15AM
Signaling to Chromatin and Human Disease
Room: Ballroom 1

Speaker 3 of 6
* Jerry L. Workman, Stowers Institute for Medical Research, USA
Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism

Tuesday, January 12 | 8:00AM - 11:15AM
Signaling to Chromatin and Human Disease
Room: Ballroom 1

Speaker 4 of 6
W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Nuclear NAD+ Signaling through DNA-dependent PARPs and the Control of Gene Expression

Tuesday, January 12 | 8:00AM - 11:15AM
Signaling to Chromatin and Human Disease
Room: Ballroom 1

Speaker 5 of 6
Juan Du, Beckman Research Institute of City of Hope, USA
Short Talk: Chromatin Variation Driven by Transposable Elements Is a Key Contributor to Liver Metabolism in Mice

Tuesday, January 12 | 8:00AM - 11:15AM
Signaling to Chromatin and Human Disease
Room: Ballroom 1

Speaker 6 of 6
Ali Shilatifard, Northwestern University, USA
Enhancer Malfunction in Cancer

Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 1 of 7
* Scott M. Dehm, University of Minnesota, USA


Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 2 of 7
Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
Nuclear Receptor-DNA Repair Crosstalk: Bench to Bedside


Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 3 of 7
John A. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA
Novel Ligands for Estrogen Receptor and Androgen Receptor Targeted Therapies


Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 4 of 7
Susan K. Logan, New York University School of Medicine, USA
Transcription Repression in Prostate Cancer


Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 5 of 7
Amy Peterson, BeiGene, USA
Advances in the Use of Selective Androgen Receptor Modulators as Cancer Therapies


Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 6 of 7
Yiru Chen Zhao, University of Illinois at Urbana-Champaign, USA
Short Talk: Prevention of Obesity Related Breast Cancer Using Pathway Preferential Estrogens


Tuesday, January 12 | 8:00AM - 11:15AM
From Chromatin to Clinic
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 7 of 7
Lisa Greene, University of Colorado Anschutz Medical Campus, USA
Short Talk: Suppression of CD8 T-cells by Tryptophan Catabolism in Triple-Negative Breast Cancer


Tuesday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, January 12 | 11:15AM - 1:00PM
Poster Setup
Room: Primrose


Tuesday, January 12 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, January 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Tuesday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, January 12 | 5:00PM - 7:00PM
Metabolism and Gene Control
Room: Ballroom 1

Speaker 1 of 5
* Melanie M. Ott, Gladstone Institutes, USA

Tuesday, January 12 | 5:00PM - 7:00PM
Metabolism and Gene Control
Room: Ballroom 1

Speaker 2 of 5
Jesper Q. Svejstrup, Francis Crick Institute, UK
Transcription-Associated Genome Instability

Tuesday, January 12 | 5:00PM - 7:00PM
Metabolism and Gene Control
Room: Ballroom 1

Speaker 3 of 5
Frances M. Sladek, University of California, Riverside, USA
Short Talk: Soybean Oil Induces Obesity via Linoleic Acid, Oxylipins and Nuclear Receptor HNF4alpha

Tuesday, January 12 | 5:00PM - 7:00PM
Metabolism and Gene Control
Room: Ballroom 1

Speaker 4 of 5
Katherine A. Jones, The Salk Institute, USA
Metabolic Role for CTD Kinases

Tuesday, January 12 | 5:00PM - 7:00PM
Metabolism and Gene Control
Room: Ballroom 1

Speaker 5 of 5
Joaquín M. Espinosa, Linda Crnic Institute for Down Syndrome, USA
Mechanisms of Transcriptional Control by HIF1 and its Cofactors in Response to Hypoxia

Tuesday, January 12 | 5:00PM - 7:00PM
Advances in Structures, Ligands and Energetics
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 1 of 5
* Myles Brown, Dana-Farber Cancer Institute, USA


Tuesday, January 12 | 5:00PM - 7:00PM
Advances in Structures, Ligands and Energetics
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 2 of 5
Nima Sharifi, Cleveland Clinic, USA
Feeding the Ligand Addiction in Advanced Cancers


Tuesday, January 12 | 5:00PM - 7:00PM
Advances in Structures, Ligands and Energetics
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 3 of 5
Kendall W. Nettles, The Scripps Research Institute, USA
Predicting Phenotypic Outcomes for Estrogen Receptor Ligands


Tuesday, January 12 | 5:00PM - 7:00PM
Advances in Structures, Ligands and Energetics
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 4 of 5
David L. Bain, University of Colorado Anschutz Medical Campus, USA
Nuclear Receptor Functional Energetics and Transcriptional Regulation


Tuesday, January 12 | 5:00PM - 7:00PM
Advances in Structures, Ligands and Energetics
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 5 of 5
Kerry Kornfeld, Washington University Medical School, USA
Short Talk: The Nuclear Receptor HIZR-1 Mediates Zinc Homeostasis by Functioning as a Zinc Sensor and Transcription Response Effector


Tuesday, January 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Tuesday, January 12 | 7:30PM - 10:00PM
Poster Session 2
Room: Primrose


Wednesday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, January 13 | 8:00AM - 11:00AM
Metabolism and Tumor Suppression
Room: Ballroom 1

Speaker 1 of 6
* Jane Mellor, University of Oxford, UK

Wednesday, January 13 | 8:00AM - 11:00AM
Metabolism and Tumor Suppression
Room: Ballroom 1

Speaker 2 of 6
Jennifer Jones McCann, Thomas Jefferson University, USA
Short Talk: Novel Action of p53 Gain-of-Function Mutations in Prostate Cancer Progression

Wednesday, January 13 | 8:00AM - 11:00AM
Metabolism and Tumor Suppression
Room: Ballroom 1

Speaker 3 of 6
Amanda G. Fisher, Imperial College London, UK
Non-Invasive Imaging of Epigenetic Changes in the Developing Embryo

Wednesday, January 13 | 8:00AM - 11:00AM
Metabolism and Tumor Suppression
Room: Ballroom 1

Speaker 4 of 6
Adrian P. Bracken, Trinity College Dublin, Ireland
The PRC2 Complex in Cellular Proliferation and Cancer

Wednesday, January 13 | 8:00AM - 11:00AM
Metabolism and Tumor Suppression
Room: Ballroom 1

Speaker 5 of 6
Selma Masri, University of California, Irvine, USA
Short Talk: Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

Wednesday, January 13 | 8:00AM - 11:00AM
Metabolism and Tumor Suppression
Room: Ballroom 1

Speaker 6 of 6
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Metabolic Regulation of Epigenetics

Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 1 of 7
* Kenneth S. Korach, NIEHS, National Institutes of Health, USA


Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 2 of 7
Ellis R. Levin, University of California, Irvine, USA
Membrane and Nuclear-Only ERalpha Mice Inform Phenotypes and Metabolic Functions Resulting from Estrogen Action


Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 3 of 7
Cheryl L. Walker, Baylor College of Medicine, USA
Environmental Estrogens Activate Nongenomic ER Signaling to Developmentally Reprogram the Epigenome


Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 4 of 7
Stephen R. Hammes, University of Rochester Medical Center, USA
Crosstalk between Estrogen and mTOR Signaling in Lymphangioleiomyomatosis (LAM)


Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 5 of 7
Zeynep Madak-Erdogan, University of Illinois at Urbana-Champaign, USA
Systems Biology of Gene and Metabolic Regulation by Estrogen Receptors and Kinases in Breast Cancer and Metabolic Disease


Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 6 of 7
Rebecca B. Riggins, Georgetown University, USA
Short Talk: The Extra-Nuclear Life of ERRbeta2: Cytoskeletal and Mitotic Functions of an Orphan Nuclear Receptor Splice Variant


Wednesday, January 13 | 8:00AM - 11:15AM
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NR
s
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 7 of 7
Andrea R. Patterson, Ohio State University, USA
Short Talk: The Role of Stromal Estrogen Receptor in Mammary Gland Reprogramming Following in Utero BPA Exposure


Wednesday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Wednesday, January 13 | 11:00AM - 1:00PM
Poster Setup
Room: Primrose


Wednesday, January 13 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Wednesday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, January 13 | 5:00PM - 7:00PM
Circadian and Metabolic Cycles (Joint)
Room: Ballroom 1-3

Speaker 1 of 5
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Wednesday, January 13 | 5:00PM - 7:00PM
Circadian and Metabolic Cycles (Joint)
Room: Ballroom 1-3

Speaker 2 of 5
Ronald M. Evans, HHMI/The Salk Institute, USA
Nuclear Receptors—Physiology's Architect: A 30 Year Perspective

Wednesday, January 13 | 5:00PM - 7:00PM
Circadian and Metabolic Cycles (Joint)
Room: Ballroom 1-3

Speaker 3 of 5
Paolo Sassone-Corsi, University of California, Irvine, USA
Metabolic and Epigenetic Language of the Circadian Clock

Wednesday, January 13 | 5:00PM - 7:00PM
Circadian and Metabolic Cycles (Joint)
Room: Ballroom 1-3

Speaker 4 of 5
Jane Mellor, University of Oxford, UK
Transcriptional Regulation of the Metabolic Cycle

Wednesday, January 13 | 5:00PM - 7:00PM
Circadian and Metabolic Cycles (Joint)
Room: Ballroom 1-3

Speaker 5 of 5
Ronald M. Evans, HHMI/The Salk Institute, USA
Nuclear Receptors and the Circadian Clock

Wednesday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Wednesday, January 13 | 7:30PM - 10:00PM
Poster Session 3
Room: Primrose


Thursday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, January 14 | 8:00AM - 9:00AM
Keynote Address
Room: Ballroom 1

Speaker 1 of 2
* Paolo Sassone-Corsi, University of California, Irvine, USA

Thursday, January 14 | 8:00AM - 9:00AM
Keynote Address
Room: Ballroom 1

Speaker 2 of 2
Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Control of Brown and Beige Fat: Basic Biology and Potential Therapeutic Pathways

Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 1 of 7
* Jonna Frasor, University of Illinois, Chicago, USA


Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 2 of 7
Christine Louise Clarke, Westmead Millennium Institute, Australia
Progesterone Action in Normal Breast and Breast Cancer


Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 3 of 7
Gail S. Prins, University of Illinois, USA
Estrogenic Regulation of Prostate Stem and Progenitor Cells: Differential Actions through ERalpha and ERbeta


Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 4 of 7
Jennifer K. Richer, University of Colorado Anschutz Medical Campus, USA
Subtype-Specific AR Action in Breast Cancer


Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 5 of 7
John A. Cidlowski, NIEHS, National Institutes of Health, USA
Stress Hormone Signaling and Heart Disease: The Good, the Bad, and the Deadly


Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 6 of 7
Diana M. Cittelly, University of Colorado Anschutz Medical Campus, USA
Short Talk: Ovarian and Brain Estrogens Promote Brain Metastases of Triple-Negative Breast Cancer


Thursday, January 14 | 8:00AM - 11:15AM
Nuclear Receptors in Cancer, Gender Benders and Other Advanc
es
This session is from Nuclear Receptors

Room: Ballroom 2-3

Speaker 7 of 7
Christopher M. McNair, Thomas Jefferson University, USA
Short Talk: RB Loss Re-Programs E2F1 and AR Cistromes in Prostate Cancer


Thursday, January 14 | 9:00AM - 11:15AM
Obesity, Diabetes and Misregulation of Gene Expression
Room: Ballroom 1

Speaker 1 of 5
* Paolo Sassone-Corsi, University of California, Irvine, USA

Thursday, January 14 | 9:00AM - 11:15AM
Obesity, Diabetes and Misregulation of Gene Expression
Room: Ballroom 1

Speaker 2 of 5
Amandine Chaix, The Salk Institute for Biological Studies, USA
Short Talk: Time-Restricted Feeding is a Preventative and Therapeutic Intervention Against Diverse Nutritional Challenges

Thursday, January 14 | 9:00AM - 11:15AM
Obesity, Diabetes and Misregulation of Gene Expression
Room: Ballroom 1

Speaker 3 of 5
Carl S. Thummel, University of Utah School of Medicine, USA
Regulation of Mitochondrial Transcription and Carbohydrate Homeostasis by the HNF4 Nuclear Receptor

Thursday, January 14 | 9:00AM - 11:15AM
Obesity, Diabetes and Misregulation of Gene Expression
Room: Ballroom 1

Speaker 4 of 5
Shingo Kajimura, Harvard Medical School, Beth Israel Deaconess Medical Center, USA
Molecular Basis of Beige Adipocyte Maintenance and Energy Expenditure

Thursday, January 14 | 9:00AM - 11:15AM
Obesity, Diabetes and Misregulation of Gene Expression
Room: Ballroom 1

Speaker 5 of 5
Anders M. Näär, University of California, Berkeley, USA
Transcriptional and MicroRNA Circuits in Metabolic Disorder

Thursday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Thursday, January 14 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 1 of 8
* Carol A. Lange, University of Minnesota, USA


Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 2 of 8
Christy Hagan, University of Kansas Medical Center, USA
Progesterone Receptor Promotes Inflammatory Gene Programs in Breast Cancer


Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 3 of 8
Lynsey M. Fettig, University of Colorado, USA
Progesterone Receptor-Retinoic Acid Receptor Crosstalk in Regulating a Breast Cancer Stem Cell Population


Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 4 of 8
Michael A. Gordon, University of Colorado Anschutz Medical Campus, USA
Targeting Multiple Pathways in Breast Cancer: Androgen Receptor, HER2, and mTOR


Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 5 of 8
Daniel E. Frigo, University of Houston, USA
Regulation of AMPK by Androgen Receptor Signaling and its Role in Prostate Cancer Metabolism


Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 6 of 8
Zhenqi Zhou, University of California, Los Angeles, USA
ERalpha Deficiency-Induced Mitochondrial Dysfunction and Skeletal Muscle Insulin Resistance is Mediated by Imbalanced Fission-Fusion Dynamics in Females


Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 7 of 8
Hari Singhal, University of Chicago, USA
Progesterone Receptor Agonists, Antagonists and Isoforms Differentially Reprogram Estrogen Signaling in Breast Cancer


Thursday, January 14 | 2:30PM - 4:30PM
Workshop 2: Signal Transduction and NR Actions
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 8 of 8
Nancy R. Gough, National Breast Cancer Coalition, USA
Presentation on Science Writing


Thursday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, January 14 | 5:00PM - 7:00PM
Transcriptional Control of Cell Growth
Room: Ballroom 1

Speaker 1 of 5
* Katherine A. Jones, The Salk Institute, USA

Thursday, January 14 | 5:00PM - 7:00PM
Transcriptional Control of Cell Growth
Room: Ballroom 1

Speaker 2 of 5
James T. Kadonaga, University of California, San Diego, USA
Operating Systems, Apps, and Novel Chromatin Structures for the Regulation of Our Genes

Thursday, January 14 | 5:00PM - 7:00PM
Transcriptional Control of Cell Growth
Room: Ballroom 1

Speaker 3 of 5
Claudio J. Villanueva, University of California, Los Angeles, USA
Short Talk: TLE3 is a Gatekeeper of the Beige Transcriptional Program

Thursday, January 14 | 5:00PM - 7:00PM
Transcriptional Control of Cell Growth
Room: Ballroom 1

Speaker 4 of 5
Don Ayer, University of Utah, USA
c-Myc and MondoA Couple Nutrient Utilization and Availability in Tumorigenesis

Thursday, January 14 | 5:00PM - 7:00PM
Transcriptional Control of Cell Growth
Room: Ballroom 1

Speaker 5 of 5
Peter Verrijzer, Erasmus University Medical Center, Netherlands
Transcription Control by Nucleotide Biosynthetic Enzymes

Thursday, January 14 | 5:00PM - 6:00PM
NRs as Modulators of Immune Cell Function
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 1 of 3
* Jennifer K. Richer, University of Colorado Anschutz Medical Campus, USA


Thursday, January 14 | 5:00PM - 6:00PM
NRs as Modulators of Immune Cell Function
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 2 of 3
Inez Rogatsky, Weill Medical College of Cornell University, USA
Transcriptional Cofactor NCoA2/GRIP1 in Macrophage Polarization and Metabolic Control


Thursday, January 14 | 5:00PM - 6:00PM
NRs as Modulators of Immune Cell Function
This session is from Nuclear Receptors
Room: Ballroom 2-3

Speaker 3 of 3
Christopher K. Glass, University of California, San Diego, USA
Influence of Tissue Environment on Macrophage Identity and Function


Thursday, January 14 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Nuclear Receptors
Room: Ballroom 2-3


Thursday, January 14 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Ballroom 2-3
No registration fees are used to fund alcohol served at this function.

Thursday, January 14 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2-3
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 14 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 2-3


Friday, January 15 | 10:25AM - 10:25AM
Departure


*Session Chair.