Web Desc
Axons: From Cell Biology to Pathology
joint with Traumatic Brain Injury: Clinical, Pathological and Translational Mechanisms
Organizer(s): Giampietro Schiavo, Bruce D. Carter and Rejji Kuruvilla
Date: January 24 - 27, 2016
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Supported by the Directors' Fund
Summary of Meeting:
The development and maintenance of axons require efficient long-range communication in the nervous system. Axons extend distances ranging from a fraction of a millimeter to more than a meter in humans, lengths that require specialized mechanisms for formation, maintenance and regeneration. Given their extreme polarity and size, axons are particularly vulnerable to the risk of degeneration and dysfunction upon injury or disease. This Keystone Symposia meeting will bring together scientists from multiple disciplines interested in the common goal of addressing problems rooted in axonal cell biology, such as intracellular transport of organelles and guidance, with a view to accelerating progress in the field of axonal biology and pathology. This is a unique meeting that will cover a broad spectrum of the latest developments in axonal research, from development and maintenance, through to survival and repair, in both the central and peripheral nervous system. Additional topics and late-breaking developments will be incorporated via talks selected from abstracts, specifically encouraging participation of young researchers and those new to the field. The multidisciplinary theme and shared focus will facilitate communication from basic to clinical neuroscience, bridging these two communities and creating unique opportunities to synergize and collaborate.
Scholarship Deadline: September 24 2015
Discounted Abstract Deadline: September 24 2015
Abstract Deadline: October 27 2015
Discounted Registration Deadline: December 18 2015
We gratefully acknowledge additional support for this conference from:
Chroma Technology CorporationIntegra Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
NeuroscientistNews
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 24 | 4:00PM - 8:00PM
Arrival and Registration
Room: Eldorado Lounge


Sunday, January 24 | 6:00PM - 8:00PM
Welcome Mixer
Room: Eldorado Lounge
No registration fees are used to fund alcohol served at this function.

Monday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Monday, January 25 | 7:30AM - 8:00AM
Poster Setup
Room: Anasazi Ballroom


Monday, January 25 | 8:00AM - 5:00PM
Poster Viewing
Room: Anasazi Ballroom


Monday, January 25 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado B

Speaker 1 of 4
* Giampietro Schiavo, University College London, UK

Monday, January 25 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado B

Speaker 2 of 4
* Bruce D. Carter, Vanderbilt University School of Medicine, USA

Monday, January 25 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado B

Speaker 3 of 4
* Rejji Kuruvilla, Johns Hopkins University, USA

Monday, January 25 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado B

Speaker 4 of 4
Karl Deisseroth, Stanford University, USA
Structural and Molecular Interrogation of Intact Biological Systems

Monday, January 25 | 9:00AM - 11:15AM
Axon Cytoskeleton and Specification
Room: Eldorado B

Speaker 1 of 5
Melissa Rolls, Pennsylvania State University, USA
Using Live Imaging of Dynamic Microtubules to Understand Axon Injury Responses

Monday, January 25 | 9:00AM - 11:15AM
Axon Cytoskeleton and Specification
Room: Eldorado B

Speaker 2 of 5
Erik Dent, University of Wisconsin-Madison, USA
Role of an F-BAR Protein in Inhibiting Axon Outgrowth

Monday, January 25 | 9:00AM - 11:15AM
Axon Cytoskeleton and Specification
Room: Eldorado B

Speaker 3 of 5
Francisca C. Bronfman, Catholic University, Chile
Short Talk: Axonal BDNF Promotes Local Axonal Synthesis and Retrograde Transport of the Transcription Factor PPARgamma in an mTOR-Dependent Manner

Monday, January 25 | 9:00AM - 11:15AM
Axon Cytoskeleton and Specification
Room: Eldorado B

Speaker 4 of 5
Christopher V. Gabel, Boston University School of Medicine, USA
Short Talk: The What, Where, and When of Activity Induced Calcium Signaling in Neuronal Regeneration

Monday, January 25 | 9:00AM - 11:15AM
Axon Cytoskeleton and Specification
Room: Eldorado B

Speaker 5 of 5
Jing Jin, Institute of Molecular Cell Biology, Germany
Short Talk: Ndr1/2 Kinases Regulate Neuronal Polarity through the Regulation of Par3

Monday, January 25 | 9:00AM - 11:30AM
What Are the Effects of TBI? Evidence from Human Observation
al Studies
This session is from Traumatic Brain Injury

Room: Eldorado A

Speaker 1 of 6
* Lee E. Goldstein, Boston University, USA


Monday, January 25 | 9:00AM - 11:30AM
What Are the Effects of TBI? Evidence from Human Observation
al Studies
This session is from Traumatic Brain Injury

Room: Eldorado A

Speaker 2 of 6
Ann C. McKee, Boston University / VA Boston Healthcare System, USA
Potential Long-Term Effects of Repetitive Concussive and Subconcussive Trauma


Monday, January 25 | 9:00AM - 11:30AM
What Are the Effects of TBI? Evidence from Human Observation
al Studies
This session is from Traumatic Brain Injury

Room: Eldorado A

Speaker 3 of 6
Alon Friedman, Ben-Gurion University of the Negev, Israel
Blood-Brain Barrier Dysfunction as a Biomarker and Target for Treatment in Brain Injuries


Monday, January 25 | 9:00AM - 11:30AM
What Are the Effects of TBI? Evidence from Human Observation
al Studies
This session is from Traumatic Brain Injury

Room: Eldorado A

Speaker 4 of 6
Alan Pearce, University of Melbourne, Australia
Using Transcranial Magnetic Stimulation to Measure Neurophysiological Responses Following Concussion


Monday, January 25 | 9:00AM - 11:30AM
What Are the Effects of TBI? Evidence from Human Observation
al Studies
This session is from Traumatic Brain Injury

Room: Eldorado A

Speaker 5 of 6
Jillian Urban, Wake Forest University, USA
Short Talk: Cumulative Head Impact Exposure in Youth Football Players


Monday, January 25 | 9:00AM - 11:30AM
What Are the Effects of TBI? Evidence from Human Observation
al Studies
This session is from Traumatic Brain Injury

Room: Eldorado A

Speaker 6 of 6
Daniel Daneshvar, Boston University, USA
Short Talk: Examining Repetitive Head Impact Exposure Metrics and Risk of Chronic Traumatic Encephalopathy in American Football Players


Monday, January 25 | 9:40AM - 10:00AM
Coffee Break
Room: Concourse


Monday, January 25 | 11:15AM - 12:15PM
Lunch
Room: Anasazi Ballroom


Monday, January 25 | 12:00PM - 2:30PM
Poster Session 1
Room: Anasazi Ballroom


Monday, January 25 | 2:30PM - 4:30PM
Axonal Degeneration and Regeneration
Room: Eldorado B

Speaker 1 of 5
* Valeria Cavalli, Washington University, USA

Monday, January 25 | 2:30PM - 4:30PM
Axonal Degeneration and Regeneration
Room: Eldorado B

Speaker 2 of 5
Marc Hammarlund, Yale University School of Medicine, USA
Neuronal Regulation of Axon Regeneration

Monday, January 25 | 2:30PM - 4:30PM
Axonal Degeneration and Regeneration
Room: Eldorado B

Speaker 3 of 5
Trent A. Watkins, Baylor College of Medicine, USA
DLK-Dependent Regulation of the Degenerative and Regenerative Responses to Axonal Injury

Monday, January 25 | 2:30PM - 4:30PM
Axonal Degeneration and Regeneration
Room: Eldorado B

Speaker 4 of 5
Richard E. Zigmond, Case Western Reserve University, USA
Macrophages in Dorsal Root Ganglia (drgs) Promote Nerve Regeneration through a Stat3-Dependent Mechanism

Monday, January 25 | 2:30PM - 4:30PM
Axonal Degeneration and Regeneration
Room: Eldorado B

Speaker 5 of 5
Peter Walter, HHMI/University of California, San Francisco, USA
Inhibition of the Integrated Stress Response Restores Cognition After Brain Injury

Monday, January 25 | 2:30PM - 4:30PM
Workshop 1: TBI, Neuroinflammation and Microvasculopathy
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 1 of 7
* Maiken Nedergaard, University of Rochester, USA


Monday, January 25 | 2:30PM - 4:30PM
Workshop 1: TBI, Neuroinflammation and Microvasculopathy
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 2 of 7
Rita H. Nguyen, University of Calgary, Canada
Understanding the Role of Microglia Following Repetitive Mild Traumatic Brain Injury using Intravital Microscopy


Monday, January 25 | 2:30PM - 4:30PM
Workshop 1: TBI, Neuroinflammation and Microvasculopathy
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 3 of 7
Jon D. Cherry, Boston University School of Medicine, USA
Repetitive Head Injury Results in Neuroinflammation that Precedes Chronic Traumatic Encephalopathy Pathology and Scales with Disease Severity


Monday, January 25 | 2:30PM - 4:30PM
Workshop 1: TBI, Neuroinflammation and Microvasculopathy
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 4 of 7
Barry W. Festoff, University of Kansas Medical School, Phlogistix LLC, USA
TBI Effects on BBB Neuro-Gliovascular (N-GVU) Units Modeled by Inflammo-Coag Factors In Vitro


Monday, January 25 | 2:30PM - 4:30PM
Workshop 1: TBI, Neuroinflammation and Microvasculopathy
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 5 of 7
Susanna Rosi, University of California, San Francisco, USA
In vivo Metabolic Imaging of Neuroinflammation after TBI


Monday, January 25 | 2:30PM - 4:30PM
Workshop 1: TBI, Neuroinflammation and Microvasculopathy
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 6 of 7
Bertrand Russell Huber, VA Boston Healthcare, USA
Assessing Long-Term Vascular Dysfunction in Chronic Traumatic Encephalopathy with Fibrinogen Immunohistochemistry


Monday, January 25 | 2:30PM - 4:30PM
Workshop 1: TBI, Neuroinflammation and Microvasculopathy
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 7 of 7
Dara Bree, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Novel Characterisation of Headache-Related Behaviours in a Clinically Relevant Rat Model of Posttraumatic Headache


Monday, January 25 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Monday, January 25 | 5:00PM - 7:00PM
RNA Targeting and Local Translation
Room: Eldorado B

Speaker 1 of 6
* Michael Fainzilber, Weizmann Institute of Science, Israel

Monday, January 25 | 5:00PM - 7:00PM
RNA Targeting and Local Translation
Room: Eldorado B

Speaker 2 of 6
* Christopher V. Gabel, Boston University School of Medicine, USA

Monday, January 25 | 5:00PM - 7:00PM
RNA Targeting and Local Translation
Room: Eldorado B

Speaker 3 of 6
Jeffery L. Twiss, University of South Carolina, USA
Molecular Determinants for mRNA Transport into Axons

Monday, January 25 | 5:00PM - 7:00PM
RNA Targeting and Local Translation
Room: Eldorado B

Speaker 4 of 6
Dianna E. Willis, Burke-Cornell Medical Research Institute, USA
Altered RNA Binding Protein Regulation and Axonal RNA Transport in Diabetic Peripheral Neuropathy

Monday, January 25 | 5:00PM - 7:00PM
RNA Targeting and Local Translation
Room: Eldorado B

Speaker 5 of 6
Ulrich Hengst, Columbia University, USA
Short Talk: Regulation of Retrograde Transport in Axons through Local Synthesis of Dynein Adaptor Proteins

Monday, January 25 | 5:00PM - 7:00PM
RNA Targeting and Local Translation
Room: Eldorado B

Speaker 6 of 6
Alexander Jaworski, Brown University, USA
Short Talk: Operational Redundancy in Axon Guidance through the Multifunctional Receptor Robo3 and its Ligand NELL2

Monday, January 25 | 5:00PM - 7:00PM
What Are the Effects of TBI? Evidence from Neuroimaging Stud
ies
This session is from Traumatic Brain Injury

Room: Eldorado A

Speaker 1 of 4
* Alon Friedman, Ben-Gurion University of the Negev, Israel


Monday, January 25 | 5:00PM - 7:00PM
What Are the Effects of TBI? Evidence from Neuroimaging Stud
ies
This session is from Traumatic Brain Injury

Room: Eldorado A

Speaker 2 of 4
Jeffrey J. Bazarian, University of Rochester Medical Center, USA
DTI Coupled with Helmet Impact Sensors Provides Insight into the Relationship between Repetitive Head Hits and Traumatic Axonal Injury


Monday, January 25 | 5:00PM - 7:00PM
What Are the Effects of TBI? Evidence from Neuroimaging Stud
ies
This session is from Traumatic Brain Injury

Room: Eldorado A

Speaker 3 of 4
Rami Burstein, Harvard Medical School, USA
The Pathophysiology of Trauma Induced Headache


Monday, January 25 | 5:00PM - 7:00PM
What Are the Effects of TBI? Evidence from Neuroimaging Stud
ies
This session is from Traumatic Brain Injury

Room: Eldorado A

Speaker 4 of 4
Ramon Diaz-Arrastia, Uniformed Services University of the Health Sciences, USA
Overview of Neuroimaging


Monday, January 25 | 7:00PM - 7:00PM
On Own for Dinner


Monday, January 25 | 8:00PM - 10:00PM
OPTIONAL - Poster Session for Down Syndrome
Room: Hilton Santa Fe - Mesa C


Tuesday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Tuesday, January 26 | 8:00AM - 11:15AM
Axonal Signaling Mechanisms
Room: Eldorado B

Speaker 1 of 8
* Marc Hammarlund, Yale University School of Medicine, USA

Tuesday, January 26 | 8:00AM - 11:15AM
Axonal Signaling Mechanisms
Room: Eldorado B

Speaker 2 of 8
* Alexander Jaworski, Brown University, USA

Tuesday, January 26 | 8:00AM - 11:15AM
Axonal Signaling Mechanisms
Room: Eldorado B

Speaker 3 of 8
Steven J. Burden, New York University Medical Center, USA
Bi-Directional Signaling to Form and Preserve Neuromuscular Synapses

Tuesday, January 26 | 8:00AM - 11:15AM
Axonal Signaling Mechanisms
Room: Eldorado B

Speaker 4 of 8
Michael Fainzilber, Weizmann Institute of Science, Israel
From Retrograde Injury Signaling to Axon Growth Control

Tuesday, January 26 | 8:00AM - 11:15AM
Axonal Signaling Mechanisms
Room: Eldorado B

Speaker 5 of 8
Valeria Cavalli, Washington University, USA
Activating a Regeneration Program with Hypoxia

Tuesday, January 26 | 8:00AM - 11:15AM
Axonal Signaling Mechanisms
Room: Eldorado B

Speaker 6 of 8
Bruce D. Carter, Vanderbilt University School of Medicine, USA
Mechanisms of Retrograde Apoptotic Signaling by the p75 Neurotrophin Receptor

Tuesday, January 26 | 8:00AM - 11:15AM
Axonal Signaling Mechanisms
Room: Eldorado B

Speaker 7 of 8
Eva Klinman, University of Pennsylvania, USA
Short Talk: Regulation of Neuronal Trafficking and Transport by CDK5

Tuesday, January 26 | 8:00AM - 11:15AM
Axonal Signaling Mechanisms
Room: Eldorado B

Speaker 8 of 8
Patti Murphy, University of Pennsylvania, USA
Short Talk: Roundabout2 and Exotosin-like 3 Promote Target Specific Peripheral Nerve Regeneration in vivo

Tuesday, January 26 | 8:00AM - 11:00AM
Mechanistic Insights from Animal Studies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 1 of 6
* John M. Lee, North Shore University Health System, USA


Tuesday, January 26 | 8:00AM - 11:00AM
Mechanistic Insights from Animal Studies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 2 of 6
Lee E. Goldstein, Boston University, USA
Acute and Chronic Neuronal Injury: Insights from Murine Models of Blast and Impact TBI


Tuesday, January 26 | 8:00AM - 11:00AM
Mechanistic Insights from Animal Studies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 3 of 6
Matt Russo, National Institutes of Health, USA
Short Talk: Role of Resident vs. Peripherally-Derived Myeloid Cells in the Immune Response to Mild Traumatic Brain Injury


Tuesday, January 26 | 8:00AM - 11:00AM
Mechanistic Insights from Animal Studies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 4 of 6
Karen Duff, Columbia University, USA
Propagation of Tau Pathology: Lessons Learned from Neurodegenerative Diseases


Tuesday, January 26 | 8:00AM - 11:00AM
Mechanistic Insights from Animal Studies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 5 of 6
Andrew Fisher, Boston University, USA
Short Talk: Comparative Modeling of Blast- and Impact-Induced Traumatic Brain Injury


Tuesday, January 26 | 8:00AM - 11:00AM
Mechanistic Insights from Animal Studies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 6 of 6
Mark Walter Wojnarowicz, Boston University, USA
Short Talk: Microvasculopathy, Blood-Brain Barrier Dysfunction, and Early Chronic Traumatic Encephalopathy-Linked Neuropathology In a Mouse Model of Concussive Impact Neurotrauma


Tuesday, January 26 | 9:20AM - 9:40AM
Coffee Break
Room: Concourse


Tuesday, January 26 | 11:15AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Tuesday, January 26 | 11:15AM - 12:30PM
On Own for Lunch


Tuesday, January 26 | 12:30PM - 2:30PM
OPTIONAL - Poster Session for Down Syndrome
Room: Hilton Santa Fe - Mesa C


Tuesday, January 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Tuesday, January 26 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Tuesday, January 26 | 5:00PM - 7:15PM
Axonal Membrane Dynamics and Axonal Transport
Room: Eldorado B

Speaker 1 of 5
* Subhojit Roy, University of Wisconsin Madison, USA

Tuesday, January 26 | 5:00PM - 7:15PM
Axonal Membrane Dynamics and Axonal Transport
Room: Eldorado B

Speaker 2 of 5
Yoshio Goshima, Yokohama City University Graduate School of Medicine, Japan
Axonal Transport Elicited by Axon Guidance Molecules

Tuesday, January 26 | 5:00PM - 7:15PM
Axonal Membrane Dynamics and Axonal Transport
Room: Eldorado B

Speaker 3 of 5
Rejji Kuruvilla, Johns Hopkins University, USA
Endocytic Trafficking of Neurotrophins in Neural Development



Tuesday, January 26 | 5:00PM - 7:15PM
Axonal Membrane Dynamics and Axonal Transport
Room: Eldorado B

Speaker 4 of 5
Casper Hoogenraad, Genentech, Inc., USA
Mechanisms of Axon Formation: Microtubule Remodeling and Motor Activity

Tuesday, January 26 | 5:00PM - 7:15PM
Axonal Membrane Dynamics and Axonal Transport
Room: Eldorado B

Speaker 5 of 5
Karen Duff, Columbia University, USA
Tau Proteinopathy, Neuronal Dyshomeostasis and Neurodegeneration

Tuesday, January 26 | 5:00PM - 7:00PM
Mechanistic Insights from Human Studies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 1 of 6
* Lee E. Goldstein, Boston University, USA


Tuesday, January 26 | 5:00PM - 7:00PM
Mechanistic Insights from Human Studies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 2 of 6
T. Blaine Hoshizaki, University of Ottawa, Canada
The Relationship between Impact Characteristics and Brain Tissue Strain Distributions


Tuesday, January 26 | 5:00PM - 7:00PM
Mechanistic Insights from Human Studies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 3 of 6
Susan Margulies, University of Pennsylvania, USA
Mechanisms of Pediatric TBI - Integrating Human and Animal Studies


Tuesday, January 26 | 5:00PM - 7:00PM
Mechanistic Insights from Human Studies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 4 of 6
Tsang-Wei Tu, National Institutes of Health, USA
Short Talk: GlucoCEST Correlates with 2DG Autoradiography in Monitoring Glucose Metabolism in Mild Traumatic Brain Injury


Tuesday, January 26 | 5:00PM - 7:00PM
Mechanistic Insights from Human Studies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 5 of 6
Ramon Diaz-Arrastia, Uniformed Services University of the Health Sciences, USA
Short Talk: DTI and MAP-MRI Abnormalities in the Closed Head Injury Model of Engineered Rotational Acceleration (CHIMERA) Mouse Model of Diffuse Axonal Injury


Tuesday, January 26 | 5:00PM - 7:00PM
Mechanistic Insights from Human Studies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 6 of 6
Cheryl Wellington, University of British Columbia, Canada
Short Talk: Traumatic Brain Injury and Steroids


Tuesday, January 26 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, January 26 | 7:30PM - 10:00PM
Poster Session 2
Room: Anasazi Ballroom


Wednesday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Wednesday, January 27 | 8:00AM - 11:00AM
Axons and Disease
Room: Eldorado B

Speaker 1 of 7
* James Shorter, University of Pennsylvania, USA

Wednesday, January 27 | 8:00AM - 11:00AM
Axons and Disease
Room: Eldorado B

Speaker 2 of 7
* Patti Murphy, University of Pennsylvania, USA

Wednesday, January 27 | 8:00AM - 11:00AM
Axons and Disease
Room: Eldorado B

Speaker 3 of 7
Sung O.K. Yoon, Ohio State University, USA
Role of JNK3 in Development of Alzheimer's

Wednesday, January 27 | 8:00AM - 11:00AM
Axons and Disease
Room: Eldorado B

Speaker 4 of 7
Vincenzo De Paola, Imperial College London, UK
Long-Term Imaging of Axon Growth and Calcium Activity in Human iPSC- Derived Neurons from Healthy and Down Syndrome Donors Grafted in the Adult Mouse Brain

Wednesday, January 27 | 8:00AM - 11:00AM
Axons and Disease
Room: Eldorado B

Speaker 5 of 7
Ralph A. Nixon, New York University, Langone Medical Center, USA
Autophagy in Neurological Disorders

Wednesday, January 27 | 8:00AM - 11:00AM
Axons and Disease
Room: Eldorado B

Speaker 6 of 7
Swetha Gowrishankar, University of Illinois at Chicago, USA
Short Talk: Contributions of Amyloid Plaque-Associated Axonal Lysosome Transport and Maturation Defects to Alzheimer’s Disease Pathology

Wednesday, January 27 | 8:00AM - 11:00AM
Axons and Disease
Room: Eldorado B

Speaker 7 of 7
Eran Perlson, Tel Aviv University, Israel

Wednesday, January 27 | 8:00AM - 11:45AM
From Precision Medicine to Therapies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 1 of 7
* Cheryl Wellington, University of British Columbia, Canada


Wednesday, January 27 | 8:00AM - 11:45AM
From Precision Medicine to Therapies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 2 of 7
Ramon Diaz-Arrastia, Uniformed Services University of the Health Sciences, USA
Endophenotypes of Traumatic Brain Injury: What We Need to Know for the Next Generation of TBI Clinical Trials


Wednesday, January 27 | 8:00AM - 11:45AM
From Precision Medicine to Therapies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 3 of 7
Kaj Blennow, University of Gothenburg, Sweden
Fluid Biomarkers for TBI – Research and Clinical Applications


Wednesday, January 27 | 8:00AM - 11:45AM
From Precision Medicine to Therapies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 4 of 7
Michael Chopp, Henry Ford Hospital, USA
Novel Neurorestorative Therapies for Remodeling the CNS and Enhancing Neurological Recovery Post TBI


Wednesday, January 27 | 8:00AM - 11:45AM
From Precision Medicine to Therapies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 5 of 7
Dallas C. Hack, USA
TBI Clinical Trials: The Path Forward


Wednesday, January 27 | 8:00AM - 11:45AM
From Precision Medicine to Therapies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 6 of 7
Tatyana Gudz, Medical University of South Carolina, USA
Short Talk: Targeting Sphingosine to Protect Mitochondria after Traumatic Brain Injury


Wednesday, January 27 | 8:00AM - 11:45AM
From Precision Medicine to Therapies
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 7 of 7
Vivian Y.H. Hook, University of California, San Diego, USA
Short Talk: Cathepsin B is a Validated Drug Target for Traumatic Brain Injury


Wednesday, January 27 | 9:20AM - 9:40AM
Coffee Break
Room: Concourse


Wednesday, January 27 | 11:00AM - 2:30PM
On Own for Lunch


Wednesday, January 27 | 2:30PM - 4:30PM
Axon-Glia-Blood Vessel Interactions
Room: Eldorado B

Speaker 1 of 6
* Jeffery L. Twiss, University of South Carolina, USA

Wednesday, January 27 | 2:30PM - 4:30PM
Axon-Glia-Blood Vessel Interactions
Room: Eldorado B

Speaker 2 of 6
* Eva Klinman, University of Pennsylvania, USA

Wednesday, January 27 | 2:30PM - 4:30PM
Axon-Glia-Blood Vessel Interactions
Room: Eldorado B

Speaker 3 of 6
Mary A. Logan, Oregon Health & Science University, USA
Age-Dependent Changes in Glial Responses to Axon Injury and Disease

Wednesday, January 27 | 2:30PM - 4:30PM
Axon-Glia-Blood Vessel Interactions
Room: Eldorado B

Speaker 4 of 6
Patrizia Casaccia, Advanced Science Research Center, USA
Epigenetic Mechanisms Modulating Oligodendroglial Development and Function

Wednesday, January 27 | 2:30PM - 4:30PM
Axon-Glia-Blood Vessel Interactions
Room: Eldorado B

Speaker 5 of 6
Chenghua Gu, Harvard Medical School, USA
Interactions between Nervous and Vascular Systems in the CNS

Wednesday, January 27 | 2:30PM - 4:30PM
Axon-Glia-Blood Vessel Interactions
Room: Eldorado B

Speaker 6 of 6
Subhojit Roy, University of Wisconsin Madison, USA
Short Talk: A Two-Tier Assembly of F-actin in Axons: 'Actin Rings' and 'Actin Trails'

Wednesday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Wednesday, January 27 | 5:00PM - 7:00PM
Axon, Pathogens and Prion-Like Proteins
Room: Eldorado B

Speaker 1 of 5
* Francisca C. Bronfman, Catholic University, Chile

Wednesday, January 27 | 5:00PM - 7:00PM
Axon, Pathogens and Prion-Like Proteins
Room: Eldorado B

Speaker 2 of 5
Giampietro Schiavo, University College London, UK
Inhibition of Specific Protein Kinases Rescues Retrograde Axonal Transport Defects in Amyotrophic Lateral Sclerosis

Wednesday, January 27 | 5:00PM - 7:00PM
Axon, Pathogens and Prion-Like Proteins
Room: Eldorado B

Speaker 3 of 5
James Shorter, University of Pennsylvania, USA
Potentiated Protein Disaggregates to Counter Neurodegenerative Disease

Wednesday, January 27 | 5:00PM - 7:00PM
Axon, Pathogens and Prion-Like Proteins
Room: Eldorado B

Speaker 4 of 5
Andres Couve, Universidad de Chile, Chile
Short Talk: The Endoplasmic Reticulum and Protein Trafficking in Axons

Wednesday, January 27 | 5:00PM - 7:00PM
Axon, Pathogens and Prion-Like Proteins
Room: Eldorado B

Speaker 5 of 5
Lauren Walker, University of Pennsylvania, USA
Short Talk: Axon Self-Destruction: Integrating Sarm1 Activation, NAD+ Depletion, and MAPK Signaling

Wednesday, January 27 | 5:00PM - 6:45PM
Therapeutic Approaches to TBI
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 1 of 5
* Ramon Diaz-Arrastia, Uniformed Services University of the Health Sciences, USA


Wednesday, January 27 | 5:00PM - 6:45PM
Therapeutic Approaches to TBI
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 2 of 5
Peter Walter, HHMI/University of California, San Francisco, USA
Short Talk: Inhibition of the Integrated Stress Response Restores Cognition after Brain Injury


Wednesday, January 27 | 5:00PM - 6:45PM
Therapeutic Approaches to TBI
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 3 of 5
Ciaran Hill, University of Cambridge, UK
Short Talk: A Novel Organotypic Brain Slice Model of Traumatic Stretch Injury


Wednesday, January 27 | 5:00PM - 6:45PM
Therapeutic Approaches to TBI
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 4 of 5
Richard M. Ransohoff, Third Rock Ventures, USA
Microglia: A Reintroduction


Wednesday, January 27 | 5:00PM - 6:45PM
Therapeutic Approaches to TBI
This session is from Traumatic Brain Injury
Room: Eldorado A

Speaker 5 of 5
David K. Menon, University of Cambridge, UK
What Do We Know About TBI? Where Do We Need To Go?


Wednesday, January 27 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Traumatic Brain Injury
Room: Eldorado A


Wednesday, January 27 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Eldorado B

Speaker 1 of 3
* Giampietro Schiavo, University College London, UK

Wednesday, January 27 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Eldorado B

Speaker 2 of 3
* Bruce D. Carter, Vanderbilt University School of Medicine, USA

Wednesday, January 27 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Eldorado B

Speaker 3 of 3
* Rejji Kuruvilla, Johns Hopkins University, USA

Wednesday, January 27 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, January 27 | 8:00PM - 11:00PM
Entertainment
Room: Anasazi Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Wednesday, January 27 | 8:30PM - 11:00PM
Cash Bar
Room: Anasazi Ballroom


Thursday, January 28 | 10:25AM - 10:25AM
Departure


*Session Chair.