Purinergic Signaling

joint with Cancer Immunotherapy: Immunity and Immunosuppression Meet Targeted Therapies

Organizer(s): Joel Linden, Mark J. Smyth, Simon C. Robson and Kenneth A. Jacobson

Sponsored by Bayer HealthCare Pharmaceuticals and Roche

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Summary of Meeting:

Purines including ATP and adenosine play dual roles as intracellular mediators of metabolism and as critical extracellular signaling molecules, the latter via 19 purinergic receptors that control responses to stress and injury. This meeting will integrate rapidly emerging information about the regulation of purine release from cells (in vesicles and via channels and transporters); signaling via membrane-associated receptors (adenosine, P2X and P2Y) and extracellular metabolism (via CD73, CD39 and other ecto-enzymes); and new structural information that is facilitating drug discovery. These processes mediate tissue responses to a continual flux of signaling purines in the extracellular space that profoundly influence inflammatory diseases, tissue repair and immune function. A focus on the effects of hypoxia, metabolic stress and cytokines will fill gaps in our current knowledge of how these factors influence signaling during the evolution of acute and chronic inflammation. An understanding of how purinergic signals are dynamically regulated is needed to identify improved therapies, e.g., for cancer immunotherapy, since tumors exploit these pathways to avoid immune surveillance. Of particular interest is the growing realization that purinergic regulation controls remodeling of inflamed tissues and the functions of innate and adaptive immune cells, endothelial cells and platelets. The significance of extracellular purines in multiple tissues will be covered. The meeting should generate new mechanistic and therapeutic concepts. Prior meetings have defined the triad of purinergic 'players' (channels, receptors and enzymes) generally in unstressed animals. The meeting will focus on the paradigm-shifting realization of dynamic purinergic regulation in the setting of disease progression.

Scholarship Deadline: September 29 2015

Discounted Abstract Deadline: September 29 2015

Abstract Deadline: October 29 2015

Discounted Registration Deadline: November 24 2015

Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

MedImmune

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