Web Desc
Positive-Strand RNA Viruses
Organizer(s): Raul Andino and Peter D. Nagy
Date: May 01 - 05, 2016
Location: Hyatt Regency Austin, Austin, TX, USA
Sponsored by Merck & Co., Inc.
Summary of Meeting:
Positive-stranded RNA viruses are significant and emerging human pathogens worldwide. Virus-host interactions and innate responses by the host are intensively studied areas, which promise novel, broad-range and durable antiviral approaches. Topics covered by the meeting include basic advances in research on viral replication structures, virus entry and virus evolution; virus-host interactions, discussed from the virus view on changing the host (including systems biology) and host responses and defense mechanisms; and emerging therapeutics. It is anticipated that rapidly emerging new concepts on virus-host interactions will help the participants to test various host factors for a large number of positive-strand RNA viruses to expand the arsenal of antiviral approaches. This meeting will bring together experts on positive-stranded RNA viruses that will facilitate the rapid progress and dissemination of new concepts in the complex field of virus-host interactions. Also, speakers who are expert with other groups of viruses will be invited to facilitate cross-talk with other areas in virology. Among the speakers will be interdisciplinary scientists who would not normally meet with this group of researchers. Virology, cell biology, genetics, evolution, macromolecular structures/assembly, systems biology and imaging will all be brought together.
Scholarship Deadline: January 6 2016
Discounted Abstract Deadline: January 6 2016
Abstract Deadline: February 3 2016
Discounted Registration Deadline: March 2 2016
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Merck & Co., Inc.
We gratefully acknowledge additional support for this conference from:

International Symposium on Positive Strand RNA Viruses
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI124477-01
Funding for this conference was made possible (in part) by 1 R13 AI 124477 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, May 01 | 4:00PM - 8:00PM
Arrival and Registration
Room: Zilker North Lobby


Sunday, May 01 | 6:00PM - 8:00PM
Welcome Mixer
Room: Zilker North Lobby
No registration fees are used to fund alcohol served at this function.

Monday, May 02 | 7:30AM - 8:30AM
Breakfast
Room: Zilker 1-2


Monday, May 02 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Zilker 3-4

Speaker 1 of 2
* Raul Andino, University of California, San Francisco, USA

Monday, May 02 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Zilker 3-4

Speaker 2 of 2
Anna Marie Pyle, Yale University, USA
Viral RNA Structure and its Recognition by Host and Viral Proteins

Monday, May 02 | 9:30AM - 11:45AM
Systems Biology: From 'Omics' to Function
Room: Zilker 3-4
Host-virus interaction uncovered by integration of large data sets (genomics, proteomics, functional genomics, etc.).
Speaker 1 of 6
* Peter D. Nagy, University of Kentucky, USA

Monday, May 02 | 9:30AM - 11:45AM
Systems Biology: From 'Omics' to Function
Room: Zilker 3-4
Host-virus interaction uncovered by integration of large data sets (genomics, proteomics, functional genomics, etc.).
Speaker 2 of 6
Priya S. Shah, University of California, Davis, USA
Proteomics, Functional Genomics, eMAPs on Dengue Virus Replicating in Humans and Mosquitoes

Monday, May 02 | 9:30AM - 11:45AM
Systems Biology: From 'Omics' to Function
Room: Zilker 3-4
Host-virus interaction uncovered by integration of large data sets (genomics, proteomics, functional genomics, etc.).
Speaker 3 of 6
Shin-Ru Shih, Chang Gung University, Taiwan
Host-Factors Involved in Enterovirus Replication

Monday, May 02 | 9:30AM - 11:45AM
Systems Biology: From 'Omics' to Function
Room: Zilker 3-4
Host-virus interaction uncovered by integration of large data sets (genomics, proteomics, functional genomics, etc.).
Speaker 4 of 6
Benjamin R. TenOever, Icahn School of Medicine at Mount Sinai, USA
Functional Antiviral Genomics through in vivo RNAi Screens

Monday, May 02 | 9:30AM - 11:45AM
Systems Biology: From 'Omics' to Function
Room: Zilker 3-4
Host-virus interaction uncovered by integration of large data sets (genomics, proteomics, functional genomics, etc.).
Speaker 5 of 6
Jan E. Carette, Stanford University, USA
Short Talk: Genetic Knockout Screens Identify Host Genes Required For Dengue Virus Replication

Monday, May 02 | 9:30AM - 11:45AM
Systems Biology: From 'Omics' to Function
Room: Zilker 3-4
Host-virus interaction uncovered by integration of large data sets (genomics, proteomics, functional genomics, etc.).
Speaker 6 of 6
Sunnie R. Thompson, University of Alabama, Birmingham, USA
Short Talk: Identification of Host Factors that Interact with Dengue Virus RNA in Cell Culture

Monday, May 02 | 10:00AM - 10:20AM
Coffee Break
Room: Zilker North Lobby


Monday, May 02 | 11:45AM - 5:00PM
On Own for Lunch


Monday, May 02 | 11:45AM - 1:00PM
Poster Setup
Room: Zilker 1-2


Monday, May 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Zilker 1-2


Monday, May 02 | 2:30PM - 4:30PM
Workshop 1: Recombination and Replication Fidelity, RdRp Str
ucture
Room: Zilker 3-4

Speaker 1 of 9
* Karla A. Kirkegaard, Stanford University School of Medicine, USA

Monday, May 02 | 2:30PM - 4:30PM
Workshop 1: Recombination and Replication Fidelity, RdRp Str
ucture
Room: Zilker 3-4

Speaker 2 of 9
David J. Barton, University of Colorado Denver, USA
Polymerase Structure-Function and Picornavirus RNA Recombination

Monday, May 02 | 2:30PM - 4:30PM
Workshop 1: Recombination and Replication Fidelity, RdRp Str
ucture
Room: Zilker 3-4

Speaker 3 of 9
Patrick T. Dolan, Stanford University, USA
Population Sequencing Reveals the Host-Specific Adaptive Landscapes of Dengue Virus

Monday, May 02 | 2:30PM - 4:30PM
Workshop 1: Recombination and Replication Fidelity, RdRp Str
ucture
Room: Zilker 3-4

Speaker 4 of 9
Gonzalo Moratorio, Institut Pasteur, France
Cornering RNA Viruses by Constraining their Sequence Space

Monday, May 02 | 2:30PM - 4:30PM
Workshop 1: Recombination and Replication Fidelity, RdRp Str
ucture
Room: Zilker 3-4

Speaker 5 of 9
Craig E. Cameron, UNC School of Medicine, USA
New, Functional Forms of HCV NS5A Protein in vivo?

Monday, May 02 | 2:30PM - 4:30PM
Workshop 1: Recombination and Replication Fidelity, RdRp Str
ucture
Room: Zilker 3-4

Speaker 6 of 9
Alexander E. Gorbalenya, Leiden University Medical Center, Netherlands
NiRAN, Nidovirus RdRp-Associated Nucleotidyltransferase: First Enzyme Exclusively Associated with an Order of +RNA Viruses

Monday, May 02 | 2:30PM - 4:30PM
Workshop 1: Recombination and Replication Fidelity, RdRp Str
ucture
Room: Zilker 3-4

Speaker 7 of 9
James Bert Flanegan, University of Florida, USA
Poliovirus Multifunctional Precursor Proteins Required for Replication Complex Assembly, VPgpUpU Synthesis and RNA Replication

Monday, May 02 | 2:30PM - 4:30PM
Workshop 1: Recombination and Replication Fidelity, RdRp Str
ucture
Room: Zilker 3-4

Speaker 8 of 9
Kay Choi, University of Texas Medical Branch, USA
Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

Monday, May 02 | 2:30PM - 4:30PM
Workshop 1: Recombination and Replication Fidelity, RdRp Str
ucture
Room: Zilker 3-4

Speaker 9 of 9
Chloé Jaubert, Universite de Bordeaux, France
RNA Genomic Dimerization and Hepatitis C Virus Replication

Monday, May 02 | 4:30PM - 5:00PM
Coffee Available
Room: Zilker North Lobby


Monday, May 02 | 5:00PM - 7:00PM
Entry, Trafficking and Exiting
Room: Zilker 3-4
Virus receptor interactions, intracellular trafficking, and mechanisms of egress.
Speaker 1 of 5
* Andres Merits, University of Tartu, Estonia

Monday, May 02 | 5:00PM - 7:00PM
Entry, Trafficking and Exiting
Room: Zilker 3-4
Virus receptor interactions, intracellular trafficking, and mechanisms of egress.
Speaker 2 of 5
Félix Rey, Institut Pasteur, France
Eliciting Cross-Reactive Antibodies Neutralizing Dengue Virus: A Structural View

Monday, May 02 | 5:00PM - 7:00PM
Entry, Trafficking and Exiting
Room: Zilker 3-4
Virus receptor interactions, intracellular trafficking, and mechanisms of egress.
Speaker 3 of 5
Carolyn B. Coyne, University of Pittsburgh, USA
Roadblocks: Polarized Cells as Barriers to RNA Virus Entry and Infection

Monday, May 02 | 5:00PM - 7:00PM
Entry, Trafficking and Exiting
Room: Zilker 3-4
Virus receptor interactions, intracellular trafficking, and mechanisms of egress.
Speaker 4 of 5
Julie K. Pfeiffer, University of Texas Southwestern Medical Center, USA
Enteroviruses and the Microbiota

Monday, May 02 | 5:00PM - 7:00PM
Entry, Trafficking and Exiting
Room: Zilker 3-4
Virus receptor interactions, intracellular trafficking, and mechanisms of egress.
Speaker 5 of 5
Maria Guadalupe Martinez, INSERM 1052 Centre de Recherche en Cancerologie, CNRS 5286, France
Short Talk: Alphavirus Budding: How Viruses Remodel the Cell During Exit

Monday, May 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Zilker 1-2
No registration fees are used to fund alcohol served at this function.

Monday, May 02 | 7:30PM - 10:00PM
Poster Session 1
Room: Zilker 1-2


Tuesday, May 03 | 7:30AM - 8:30AM
Breakfast
Room: Zilker 1-2


Tuesday, May 03 | 8:00AM - 8:30AM
Poster Setup
Room: Zilker 1-2


Tuesday, May 03 | 8:30AM - 5:00PM
Poster Viewing
Room: Zilker 1-2


Tuesday, May 03 | 8:30AM - 11:30AM
Replication Organelles, Membranes, Proteins, Lipids and Stuf
f...

Room: Zilker 3-4
How do virus construct alter the cell architecture to create a RNA replication favorable environment.
Speaker 1 of 7
* Raul Andino, University of California, San Francisco, USA

Tuesday, May 03 | 8:30AM - 11:30AM
Replication Organelles, Membranes, Proteins, Lipids and Stuf
f...

Room: Zilker 3-4
How do virus construct alter the cell architecture to create a RNA replication favorable environment.
Speaker 2 of 7
Ralf Bartenschlager, Heidelberg University, Germany
Cell Biology of Viral Replication Cycles: A Comparison of Hepatitis C Virus and Dengue Virus

Tuesday, May 03 | 8:30AM - 11:30AM
Replication Organelles, Membranes, Proteins, Lipids and Stuf
f...

Room: Zilker 3-4
How do virus construct alter the cell architecture to create a RNA replication favorable environment.
Speaker 3 of 7
Richard J. Kuhn, Purdue University, USA
Structure-Function Studies of Flavivirus Replication Proteins

Tuesday, May 03 | 8:30AM - 11:30AM
Replication Organelles, Membranes, Proteins, Lipids and Stuf
f...

Room: Zilker 3-4
How do virus construct alter the cell architecture to create a RNA replication favorable environment.
Speaker 4 of 7
Frank van Kuppeveld, Utrecht University, Netherlands
Short Talk: An Enterovirus Mutant that can Replicate in the Absence of Replication Organelles

Tuesday, May 03 | 8:30AM - 11:30AM
Replication Organelles, Membranes, Proteins, Lipids and Stuf
f...

Room: Zilker 3-4
How do virus construct alter the cell architecture to create a RNA replication favorable environment.
Speaker 5 of 7
Paul Ahlquist, University of Wisconsin-Madison, USA
Protein, RNA and Membrane Interactions in Positive-Strand RNA virus Genome Replication

Tuesday, May 03 | 8:30AM - 11:30AM
Replication Organelles, Membranes, Proteins, Lipids and Stuf
f...

Room: Zilker 3-4
How do virus construct alter the cell architecture to create a RNA replication favorable environment.
Speaker 6 of 7
Michael S. Diamond, Washington University School of Medicine, USA
A Genome-Wide CRISPR/Cas9 Screen Identifies Novel Host Factors Required for Flavivirus Infection

Tuesday, May 03 | 8:30AM - 11:30AM
Replication Organelles, Membranes, Proteins, Lipids and Stuf
f...

Room: Zilker 3-4
How do virus construct alter the cell architecture to create a RNA replication favorable environment.
Speaker 7 of 7
Hongliang Wang, University of Michigan, USA
Short Talk: Pulse-Chase Imaging Reveals Continuous and Rapid Turnover of Hepatitis C Virus Replication Organelles

Tuesday, May 03 | 9:50AM - 10:10AM
Coffee Break
Room: Zilker North Lobby


Tuesday, May 03 | 11:30AM - 12:30PM
Lunch
Room: Zilker 1-2


Tuesday, May 03 | 12:00PM - 2:30PM
Poster Session 2
Room: Zilker 1-2


Tuesday, May 03 | 4:30PM - 5:00PM
Coffee Available
Room: Zilker North Lobby


Tuesday, May 03 | 5:00PM - 7:00PM
Replication Enzymes and Other Factors
Room: Zilker 3-4
Both viral and cellular proteins and RNAs catalyzing the formation of RNA progeny.
Speaker 1 of 6
* Richard William Hardy, Indiana University, USA

Tuesday, May 03 | 5:00PM - 7:00PM
Replication Enzymes and Other Factors
Room: Zilker 3-4
Both viral and cellular proteins and RNAs catalyzing the formation of RNA progeny.
Speaker 2 of 6
K. Andrew White, York University, Canada
Regulation of Tombusvirus Processes by Long-range RNA-RNA Interactions

Tuesday, May 03 | 5:00PM - 7:00PM
Replication Enzymes and Other Factors
Room: Zilker 3-4
Both viral and cellular proteins and RNAs catalyzing the formation of RNA progeny.
Speaker 3 of 6
Eric J. Snijder, Leiden University Medical Center, Netherlands
An Unprecedented Protein-Stimulated -2/-1 Ribosomal Frameshift Mechanism in Arteriviruses

Tuesday, May 03 | 5:00PM - 7:00PM
Replication Enzymes and Other Factors
Room: Zilker 3-4
Both viral and cellular proteins and RNAs catalyzing the formation of RNA progeny.
Speaker 4 of 6
John T. Patton, Indiana University, USA
How Rotaviruses Do It? RNA Synthesis in Double-Stranded RNA Viruses

Tuesday, May 03 | 5:00PM - 7:00PM
Replication Enzymes and Other Factors
Room: Zilker 3-4
Both viral and cellular proteins and RNAs catalyzing the formation of RNA progeny.
Speaker 5 of 6
Tero Ahola, University of Helsinki, Finland
Short Talk: There is One Defined Pathway for Alphavirus RNA Replication

Tuesday, May 03 | 5:00PM - 7:00PM
Replication Enzymes and Other Factors
Room: Zilker 3-4
Both viral and cellular proteins and RNAs catalyzing the formation of RNA progeny.
Speaker 6 of 6
Eric Poeschla, University of Colorado School of Medicine, USA
Short Talk: Broad Spectrum Antiviral Protection via Positive Strand RNA Virus RdRp-Mediated Stable Activation of RIG-I-Like Receptor-dependent Innate Immunity

Tuesday, May 03 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, May 04 | 7:30AM - 8:30AM
Breakfast
Room: Zilker 1-2


Wednesday, May 04 | 8:30AM - 11:30AM
Virus Modulations of Host Pathways
Room: Zilker 3-4
Host-virus interactions.
Speaker 1 of 7
* Ralf Bartenschlager, Heidelberg University, Germany

Wednesday, May 04 | 8:30AM - 11:30AM
Virus Modulations of Host Pathways
Room: Zilker 3-4
Host-virus interactions.
Speaker 2 of 7
Peter D. Nagy, University of Kentucky, USA
Tombusvirus Replicase Complex Usurps the Glycolytic Pathway for Robust Replication

Wednesday, May 04 | 8:30AM - 11:30AM
Virus Modulations of Host Pathways
Room: Zilker 3-4
Host-virus interactions.
Speaker 3 of 7
Sean P. Whelan, Harvard Medical School, USA
VSV Polymerase Architecture and Activity Regulated by Host Cell Factors

Wednesday, May 04 | 8:30AM - 11:30AM
Virus Modulations of Host Pathways
Room: Zilker 3-4
Host-virus interactions.
Speaker 4 of 7
William Jackson, University of Maryland School of Medicine, USA
Short Talk: A Novel Signaling Mechanism Induces Autophagy in Poliovirus-Infected Cells

Wednesday, May 04 | 8:30AM - 11:30AM
Virus Modulations of Host Pathways
Room: Zilker 3-4
Host-virus interactions.
Speaker 5 of 7
Karla A. Kirkegaard, Stanford University School of Medicine, USA
Noncoding RNAs and Virus Infection

Wednesday, May 04 | 8:30AM - 11:30AM
Virus Modulations of Host Pathways
Room: Zilker 3-4
Host-virus interactions.
Speaker 6 of 7
Michael Gale, Jr., University of Washington, USA
Pathogen Sensing and Response in RNA Virus Infection

Wednesday, May 04 | 8:30AM - 11:30AM
Virus Modulations of Host Pathways
Room: Zilker 3-4
Host-virus interactions.
Speaker 7 of 7
Tristan X. Jordan, University of Chicago, USA
Short Talk: AMPK Inhibition of mTOR Activity is Required for Dengue Virus-Induced Lipophagy

Wednesday, May 04 | 9:50AM - 10:10AM
Coffee Break
Room: Zilker North Lobby


Wednesday, May 04 | 11:30AM - 5:00PM
On Own for Lunch


Wednesday, May 04 | 11:30AM - 1:00PM
Poster Setup
Room: Zilker 1-2


Wednesday, May 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Zilker 1-2


Wednesday, May 04 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts and Landscapes
Room: Zilker 3-4

Speaker 1 of 9
* Eva Harris, Division of Infectious Diseases and Vaccinology, School of Public Health, USA

Wednesday, May 04 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts and Landscapes
Room: Zilker 3-4

Speaker 2 of 9
Craig B. Wilen, Washington University, USA
Discovery of a Proteinaceous Cellular Receptor for a Norovirus

Wednesday, May 04 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts and Landscapes
Room: Zilker 3-4

Speaker 3 of 9
Sue E. Crawford, Baylor College of Medicine, USA
Human Noroviruses Replicate in Stem-cell Derived Human Intestinal Enteroids

Wednesday, May 04 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts and Landscapes
Room: Zilker 3-4

Speaker 4 of 9
Jason Mackenzie, University of Melbourne, Australia
Norovirus Translation: Control at the Stress Granule-PKR-p-elf2Alpha axis

Wednesday, May 04 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts and Landscapes
Room: Zilker 3-4

Speaker 5 of 9
Alexandra Schafer, University of North Carolina at Chapel Hill, USA
The Epigenetic Landscape during MERS-CoV Infection

Wednesday, May 04 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts and Landscapes
Room: Zilker 3-4

Speaker 6 of 9
Mohsan Saeed, Rockefeller University, USA
Development of an Efficient Pan-Genotype Cell Culture System for Hepatitis C Virus

Wednesday, May 04 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts and Landscapes
Room: Zilker 3-4

Speaker 7 of 9
Ann Palmenberg, University of Wisconsin-Madison, USA
Atomic Resolution Structures of Rhinovirus C15a by Cryo-EM Show Unique Topographies and Virion Properties

Wednesday, May 04 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts and Landscapes
Room: Zilker 3-4

Speaker 8 of 9
Jessica L. Smith, Oregon Health and Sciences University, USA
A microRNA Screen Identifies the miR-34 Family as Potent Inhibitors of Flavivirus Infection and Reveals an Intersection Between the Wnt and Interferon Signaling Pathways

Wednesday, May 04 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts and Landscapes
Room: Zilker 3-4

Speaker 9 of 9
Shangmei Hou, University of Alberta, Canada
Flavivirus Infection Impairs Peroxisome Biogenesis and Early Anti-Viral Signaling

Wednesday, May 04 | 4:30PM - 5:00PM
Coffee Available
Room: Zilker North Lobby


Wednesday, May 04 | 5:00PM - 7:15PM
Evolution, Adaptation and Virus Fitness
Room: Zilker 3-4
Experimental and theoretical approaches to understanding mechanisms of virus evolution.
Speaker 1 of 6
* Craig E. Cameron, UNC School of Medicine, USA

Wednesday, May 04 | 5:00PM - 7:15PM
Evolution, Adaptation and Virus Fitness
Room: Zilker 3-4
Experimental and theoretical approaches to understanding mechanisms of virus evolution.
Speaker 2 of 6
Claus Wilke, University of Texas at Austin, USA
Next-Gen Virology: Use of Microfluidics and Live-Cell Imaging to Study Poliovirus Replication at the Single-Cell Level

Wednesday, May 04 | 5:00PM - 7:15PM
Evolution, Adaptation and Virus Fitness
Room: Zilker 3-4
Experimental and theoretical approaches to understanding mechanisms of virus evolution.
Speaker 3 of 6
Paul E. Turner, Yale University, USA
Rate of Novel Host Invasion affects Adaptability of Evolving RNA Virus Lineages

Wednesday, May 04 | 5:00PM - 7:15PM
Evolution, Adaptation and Virus Fitness
Room: Zilker 3-4
Experimental and theoretical approaches to understanding mechanisms of virus evolution.
Speaker 4 of 6
Raul Andino, University of California, San Francisco, USA
RNA Virus Population Dynamics and the Mechanisms of Adaptation

Wednesday, May 04 | 5:00PM - 7:15PM
Evolution, Adaptation and Virus Fitness
Room: Zilker 3-4
Experimental and theoretical approaches to understanding mechanisms of virus evolution.
Speaker 5 of 6
Johan Neyts, University of Leuven, Belgium
Towards Antivirals against Flavi-, Picorna-, Alpha- and Noroviruses

Wednesday, May 04 | 5:00PM - 7:15PM
Evolution, Adaptation and Virus Fitness
Room: Zilker 3-4
Experimental and theoretical approaches to understanding mechanisms of virus evolution.
Speaker 6 of 6
Mark R. Denison, Vanderbilt University Medical Center, USA
Short Talk: Identification of Coronavirus Fidelity Determinants Following Long-Term Passage of Murine Hepatitis Virus Lacking nsp14-ExoN Mediated Fidelity

Wednesday, May 04 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Zilker 1-2
No registration fees are used to fund alcohol served at this function.

Wednesday, May 04 | 7:30PM - 10:00PM
Poster Session 3
Room: Zilker 1-2


Thursday, May 05 | 7:30AM - 8:30AM
Breakfast
Room: Zilker 1-2


Thursday, May 05 | 8:30AM - 11:30AM
Immunity and Stress Responses
Room: Zilker 3-4
Virus are under pressure to replicate and in doing so cell host detect them inducing innate immunity. Is stress involved in the process? How viruses deal with stress and innate immunity responses?
Speaker 1 of 7
* Michael Gale, Jr., University of Washington, USA

Thursday, May 05 | 8:30AM - 11:30AM
Immunity and Stress Responses
Room: Zilker 3-4
Virus are under pressure to replicate and in doing so cell host detect them inducing innate immunity. Is stress involved in the process? How viruses deal with stress and innate immunity responses?
Speaker 2 of 7
Ana Fernandez-Sesma, Icahn School of Medicine at Mount Sinai, USA
Innate Immunity to Dengue Virus

Thursday, May 05 | 8:30AM - 11:30AM
Immunity and Stress Responses
Room: Zilker 3-4
Virus are under pressure to replicate and in doing so cell host detect them inducing innate immunity. Is stress involved in the process? How viruses deal with stress and innate immunity responses?
Speaker 3 of 7
Nihal Altan-Bonnet, NHLBI, National Institutes of Health, USA
Intercellular Transmission of Viral Populations with Vesicles

Thursday, May 05 | 8:30AM - 11:30AM
Immunity and Stress Responses
Room: Zilker 3-4
Virus are under pressure to replicate and in doing so cell host detect them inducing innate immunity. Is stress involved in the process? How viruses deal with stress and innate immunity responses?
Speaker 4 of 7
Scott Benjamin Biering, University of Chicago, USA
Short Talk: Replication Complexes of Positive-Strand RNA Viruses are Disrupted by Interferon-Gamma Inducible GTPases

Thursday, May 05 | 8:30AM - 11:30AM
Immunity and Stress Responses
Room: Zilker 3-4
Virus are under pressure to replicate and in doing so cell host detect them inducing innate immunity. Is stress involved in the process? How viruses deal with stress and innate immunity responses?
Speaker 5 of 7
Richard E. Lloyd, Baylor College of Medicine, USA
Enterovirus Antagonism of RNA Granules

Thursday, May 05 | 8:30AM - 11:30AM
Immunity and Stress Responses
Room: Zilker 3-4
Virus are under pressure to replicate and in doing so cell host detect them inducing innate immunity. Is stress involved in the process? How viruses deal with stress and innate immunity responses?
Speaker 6 of 7
Maria-Carla Saleh, Institut Pasteur, France
Systemic Spread of Antiviral RNAi Immunity through Extracellular Vesicles Containing Viral RNAs

Thursday, May 05 | 8:30AM - 11:30AM
Immunity and Stress Responses
Room: Zilker 3-4
Virus are under pressure to replicate and in doing so cell host detect them inducing innate immunity. Is stress involved in the process? How viruses deal with stress and innate immunity responses?
Speaker 7 of 7
Eva Harris, Division of Infectious Diseases and Vaccinology, School of Public Health, USA
Short Talk: Mechanisms of Dengue Virus NS1-Induced Endothelial Permeability and Vascular Leak

Thursday, May 05 | 9:50AM - 10:10AM
Coffee Break
Room: Zilker North Lobby


Thursday, May 05 | 11:30AM - 5:00PM
On Own for Lunch


Thursday, May 05 | 3:00PM - 4:30PM
Workshop 3: Discussion on the Emergence of ZIKA Virus and Ot
her Flaviviruses
Room: Zilker 3-4

Speaker 1 of 6
* Michael S. Diamond, Washington University School of Medicine, USA

Thursday, May 05 | 3:00PM - 4:30PM
Workshop 3: Discussion on the Emergence of ZIKA Virus and Ot
her Flaviviruses
Room: Zilker 3-4

Speaker 2 of 6
Nicholas Barrows, Duke University, USA
Repurposed Drug Candidates to Treat Zika Virus Infection in Pregnancy

Thursday, May 05 | 3:00PM - 4:30PM
Workshop 3: Discussion on the Emergence of ZIKA Virus and Ot
her Flaviviruses
Room: Zilker 3-4

Speaker 3 of 6
Bryan C. Mounce, Institut Pasteur, France
Interferon-induced Spermidine-spermine N1-Acetyltransferase and Polyamine Depletion Restrict Chikungunya and Zika Virus Transcription and Translation

Thursday, May 05 | 3:00PM - 4:30PM
Workshop 3: Discussion on the Emergence of ZIKA Virus and Ot
her Flaviviruses
Room: Zilker 3-4

Speaker 4 of 6
Hengli Tang, Florida State University, USA
Zika Virus Infection Leads to Cell Cycle Arrest and Stunted Growth of Human Cortical Neural Progenitors

Thursday, May 05 | 3:00PM - 4:30PM
Workshop 3: Discussion on the Emergence of ZIKA Virus and Ot
her Flaviviruses
Room: Zilker 3-4

Speaker 5 of 6
Douglas G. Widman, University of North Carolina at Chapel Hill, USA
A Reverse Genetics Platform to Generate Zika Virus Infectious Clones and Evaluate Viral Determinants of Pathogenesis

Thursday, May 05 | 3:00PM - 4:30PM
Workshop 3: Discussion on the Emergence of ZIKA Virus and Ot
her Flaviviruses
Room: Zilker 3-4

Speaker 6 of 6
Devika Sirohi, Purdue University, USA
The Cryo-EM Structure of Zika Virus

Thursday, May 05 | 4:30PM - 5:00PM
Coffee Available
Room: Zilker North Lobby


Thursday, May 05 | 5:00PM - 6:45PM
Therapeutic Interventions
Room: Zilker 3-4
Novel interventions targeting virus and host factors.
Speaker 1 of 5
* Maria-Carla Saleh, Institut Pasteur, France

Thursday, May 05 | 5:00PM - 6:45PM
Therapeutic Interventions
Room: Zilker 3-4
Novel interventions targeting virus and host factors.
Speaker 2 of 5
Judith Frydman, Stanford University, USA
Host Protein Homeostasis Machinery as an Antiviral Target

Thursday, May 05 | 5:00PM - 6:45PM
Therapeutic Interventions
Room: Zilker 3-4
Novel interventions targeting virus and host factors.
Speaker 3 of 5
Susan C. Baker, Loyola University Chicago, USA
Targeting Coronavirus Papain-like Proteases to Block Viral Replication and Pathogenesis

Thursday, May 05 | 5:00PM - 6:45PM
Therapeutic Interventions
Room: Zilker 3-4
Novel interventions targeting virus and host factors.
Speaker 4 of 5
Matthew Frieman, University of Maryland, USA
Short Talk: Identification and Characterization of ABL Kinase Inhibitors as Potent Inhibitors of SARS-CoV and MERS-CoV Fusion

Thursday, May 05 | 5:00PM - 6:45PM
Therapeutic Interventions
Room: Zilker 3-4
Novel interventions targeting virus and host factors.
Speaker 5 of 5
Ying Kai Chan, Harvard Medical School, USA
Short Talk: Dengue Virus NS3 Antagonizes Innate Immunity Using a Phosphomimetic-Based Mechanism

Thursday, May 05 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Zilker 3-4


Thursday, May 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Zilker 1-2
No registration fees are used to fund alcohol served at this function.

Thursday, May 05 | 8:00PM - 11:00PM
Entertainment
Room: Zilker 1-2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, May 05 | 8:00PM - 11:00PM
Cash Bar
Room: Zilker 1-2


Friday, May 06 | 10:25AM - 10:25AM
Departure


*Session Chair.