Web Desc
Fibrosis: From Basic Mechanisms to Targeted Therapies
joint with Stromal Cells in Immunity
Organizer(s): Robert Lafyatis, Paolo G.V. Martini, Dean Sheppard and Lucie Peduto
Date: February 07 - 11, 2016
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Bayer HealthCare Pharmaceuticals, Biogen, Boehringer Ingelheim Pharmaceuticals, Inc., Bristol-Myers Squibb Company, Gilead Sciences, Inc., Intercept Pharmaceuticals, Inc., Merck & Co., Inc., Regeneron Pharmaceuticals, Inc., Shire Human Genetic Therapies and Theravance Biopharma
For important information on the coronavirus, please click here
Summary of Meeting:
Fibrosis is the primary process of many diseases and the end-stage of many more, frequently leading to organ failure. However, the mechanisms leading to fibrosis have been poorly understood and available therapeutics targeting fibrosis limited. Increasingly, fibrosis is understood as a dynamic process that is orchestrated by the immune system, or activated by inflammation or cellular stress. Fibrosis of lung, kidney, skin, liver and muscle typically follow a variety of different stimuli. Advances in understanding Th2 cell responses, cell death, the inflammasome and ER and oxidative stresses provide new insights into such stimuli. Understanding the regulation of and interaction between profibrotic cytokines such as TGFb, IL-13, and CTGF are shedding additional light on fibrotic processes. Recent studies indicate that fibrosis is mediated by dedicated progenitor and resident cells within target tissues. Fibroblast and perivascular cell phenotype and differentiation are regulated not only by cytokines, but also by matrix composition and stiffness. Advances in the treatment of idiopathic pulmonary fibrosis and systemic sclerosis herald many new anti-fibrotic therapies that will soon enter clinical trials. Thus, mechanistic understandings will soon answer the long-standing clinical challenges of fibrotic and end-stage scarring diseases. This meeting aims to: 1) Present and discuss the most current and cutting-edge results regarding the mechanisms, signaling pathways, gene regulation, cells and tissues involved in fibrotic diseases and therapeutic approaches currently in development; 2) Include discussions and presentation of new ideas or paradigms that challenge existing models and expand on the knowledge of the current standard of care for fibrotic diseases; 3) Consider the future directions of the field, including the identification of the most pressing unanswered questions, the areas needing more focus, and those that would benefit from new approaches and methodologies developed and used in other related fields; 4) Stimulate collaborations in a setting conducive to focused, intense discussion among scientists with broad interests in fibrotic diseases and different targeted therapeutic approaches, including engagement with industrial partners interested in new targets in fibrotic disease; and 5) Provide a forum for trainees and new investigators to learn about current work in the field, to present their own work and to network with established investigators.
Scholarship Deadline: October 8 2015
Discounted Abstract Deadline: October 8 2015
Abstract Deadline: November 10 2015
Discounted Registration Deadline: December 8 2015
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer HealthCare PharmaceuticalsBiogenBoehringer Ingelheim Pharmaceuticals, Inc.Bristol-Myers Squibb CompanyGilead Sciences, Inc.Intercept Pharmaceuticals, Inc.Merck & Co., Inc.Regeneron Pharmaceuticals, Inc.Shire Human Genetic TherapiesTheravance Biopharma
We gratefully acknowledge additional support for this conference from:
Charles River LaboratoriesFibroGen IncorporatedProfil® Institute for Clinical Research, Inc.Promedior, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

Gilead Sciences, Inc.

Inception Sciences
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL131040-01
Funding for this conference was made possible (in part) by 1R13HL131040-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S.Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 07 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, February 07 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Monday, February 08 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 1 of 4
* Robert Lafyatis, University of Pittsburgh Medical Center, USA

Monday, February 08 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 2 of 4
* Shannon J. Turley, Genentech, Inc., USA

Monday, February 08 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 3 of 4
Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging the Immune Cell–Stromal Interface in Lymphoid Tissues and Beyond

Monday, February 08 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 4 of 4
Fiona M. Watt, King's College London School of Medicine, UK
Contribution of Different Fibroblast Lineages to Skin Fibrosis

Monday, February 08 | 9:30AM - 9:50AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 08 | 9:50AM - 12:00PM
Stromal Cells in Inflammatory Disease (Joint)
Room: Columbine Ballroom

Speaker 1 of 5
* Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland
Fibroblastric Reticular Cells: Phenotype Follows Function

Monday, February 08 | 9:50AM - 12:00PM
Stromal Cells in Inflammatory Disease (Joint)
Room: Columbine Ballroom

Speaker 2 of 5
Timothy W. Schacker, University of Minnesota, USA
Lymphoid Tissue Fibrosis in HIV Infection

Monday, February 08 | 9:50AM - 12:00PM
Stromal Cells in Inflammatory Disease (Joint)
Room: Columbine Ballroom

Speaker 3 of 5
* Robert Lafyatis, University of Pittsburgh Medical Center, USA
Dermal Fibroblast Heterogeneity and Fibrosis in Systemic Sclerosis

Monday, February 08 | 9:50AM - 12:00PM
Stromal Cells in Inflammatory Disease (Joint)
Room: Columbine Ballroom

Speaker 4 of 5
Mo Ebrahimkhani, Arizona State University, USA
Short Talk: Engineering Human Organoids with Multiple Subsets of Stromal Cells

Monday, February 08 | 9:50AM - 12:00PM
Stromal Cells in Inflammatory Disease (Joint)
Room: Columbine Ballroom

Speaker 5 of 5
Jeffrey L. Browning, Boston University School of Medicine, USA
Short Talk: Fibroblasts in the Skin of Systemic Sclerosis Patients Share Characteristics with FRC in Lymphoid Organs

Monday, February 08 | 12:00PM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Monday, February 08 | 12:00PM - 5:00PM
On Own for Lunch


Monday, February 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Monday, February 08 | 2:30PM - 4:30PM
Workshop 1
This session is from Stromal Cells
Room: Quandary Peak

Speaker 1 of 10
* Jeffrey L. Browning, Boston University School of Medicine, USA


Monday, February 08 | 2:30PM - 4:30PM
Workshop 1
This session is from Stromal Cells
Room: Quandary Peak

Speaker 2 of 10
* Shannon J. Turley, Genentech, Inc., USA


Monday, February 08 | 2:30PM - 4:30PM
Workshop 1
This session is from Stromal Cells
Room: Quandary Peak

Speaker 3 of 10
Florent Carrette, Sanford Burnham Prebys Medical Discovery Institute, USA
CD44 is a New Immune Checkpoint that Promotes T Cell Exhaustion and Chronic Viral Infection through Expression on Fibroblastic Reticular Cells


Monday, February 08 | 2:30PM - 4:30PM
Workshop 1
This session is from Stromal Cells
Room: Quandary Peak

Speaker 4 of 10
Alice E. Denton, Babraham Institute, UK
Lymph Node Stromal Cells Derive from a Distinct Embryonic FAP+ Progenitor


Monday, February 08 | 2:30PM - 4:30PM
Workshop 1
This session is from Stromal Cells
Room: Quandary Peak

Speaker 5 of 10
Juan Dubrot, Broad Institute, USA
MHCII-mediated Antigen-presentation by Lymph Node Stromal Cells in Peripheral Tolerance


Monday, February 08 | 2:30PM - 4:30PM
Workshop 1
This session is from Stromal Cells
Room: Quandary Peak

Speaker 6 of 10
Henrike Fleige, Hannover Medical School, Germany
The Role of Stromal Cells in Pathogen-induced BALT


Monday, February 08 | 2:30PM - 4:30PM
Workshop 1
This session is from Stromal Cells
Room: Quandary Peak

Speaker 7 of 10
Amanda Lund, New York University, USA
Lymphatic Vessels are Required for Efficient Viral Clearance and Adaptive Immune Induction Following Epicutaneous Vaccinia Infection


Monday, February 08 | 2:30PM - 4:30PM
Workshop 1
This session is from Stromal Cells
Room: Quandary Peak

Speaker 8 of 10
Anna-Carin Andersson Lundell, Göteborg University, Sweden
Type I and II Interferons Induce BAFF Production from Human Decidual Stromal Cells


Monday, February 08 | 2:30PM - 4:30PM
Workshop 1
This session is from Stromal Cells
Room: Quandary Peak

Speaker 9 of 10
Helen M. McGettrick, University of Birmingham, UK
Identification of a Transitional Fibroblast Functional Phenotype in Early Rheumatoid Arthritis


Monday, February 08 | 2:30PM - 4:30PM
Workshop 1
This session is from Stromal Cells
Room: Quandary Peak

Speaker 10 of 10
Sarajo Mohanta, Ludwig-Maximilians University Munich, Germany
Chameleons in the Arterial Wall: Vascular Smooth Muscle Cells Transdifferentiate into Lymphoid Tissue Organizer Cells and Control Atherosclerosis Immunity


Monday, February 08 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 08 | 5:00PM - 7:00PM
Metabolic Stress and Fibrogenesis
Room: Grays/Longs Peak

Speaker 1 of 6
* Mauricio Rojas, University of Pittsburgh, USA

Monday, February 08 | 5:00PM - 7:00PM
Metabolic Stress and Fibrogenesis
Room: Grays/Longs Peak

Speaker 2 of 6
* Maria Trojanowska, Boston University School of Medicine, USA

Monday, February 08 | 5:00PM - 7:00PM
Metabolic Stress and Fibrogenesis
Room: Grays/Longs Peak

Speaker 3 of 6
Timothy S. Blackwell, Vanderbilt University School of Medicine, USA
ER Stress in Lung Fibrosis

Monday, February 08 | 5:00PM - 7:00PM
Metabolic Stress and Fibrogenesis
Room: Grays/Longs Peak

Speaker 4 of 6
Ana L. Mora, University of Pittsburgh, USA
Fibrosis as a Disease of Aging and Mitochondrial Dysfunction

Monday, February 08 | 5:00PM - 7:00PM
Metabolic Stress and Fibrogenesis
Room: Grays/Longs Peak

Speaker 5 of 6
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Fat Inflammation, Fibrosis and Remodeling

Monday, February 08 | 5:00PM - 7:00PM
Metabolic Stress and Fibrogenesis
Room: Grays/Longs Peak

Speaker 6 of 6
Kamran Atabai, University of California, San Francisco, USA
Short Talk: Functional Genomic Screen Identifies Novel Mediators of Collagen Uptake

Monday, February 08 | 5:00PM - 7:15PM
Stromal Cell Function in the Initiation of Adaptive Immunity
This session is from Stromal Cells
Room: Quandary Peak

Speaker 1 of 5
* Theresa T. Lu, Hospital for Special Surgery/Weill Cornell Medicine, USA
Regulating Lymph Node Vascular-Stromal Growth and Survival in Immunity


Monday, February 08 | 5:00PM - 7:15PM
Stromal Cell Function in the Initiation of Adaptive Immunity
This session is from Stromal Cells
Room: Quandary Peak

Speaker 2 of 5
Antal Rot, University of York, UK
Expression and Function of Atypical Chemokine Receptor 4 in Salivary Glands


Monday, February 08 | 5:00PM - 7:15PM
Stromal Cell Function in the Initiation of Adaptive Immunity
This session is from Stromal Cells
Room: Quandary Peak

Speaker 3 of 5
* Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Lymph Node Fibroblast Reticular Cells in Regulation of Humoral Immunity


Monday, February 08 | 5:00PM - 7:15PM
Stromal Cell Function in the Initiation of Adaptive Immunity
This session is from Stromal Cells
Room: Quandary Peak

Speaker 4 of 5
Mark C. Coles, University of Oxford, UK
Short Talk: Role of microRNA Mediated Stromal Remodeling in Vaccine Efficacy


Monday, February 08 | 5:00PM - 7:15PM
Stromal Cell Function in the Initiation of Adaptive Immunity
This session is from Stromal Cells
Room: Quandary Peak

Speaker 5 of 5
Sanjiv A. Luther, University of Lausanne, Switzerland
Short Talk: Identification of a New Fibroblast Subset Forming Plasma Cell Survival Niches in Activated Lymph Nodes


Monday, February 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, February 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Colorado Rockies Ballroom


Tuesday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Tuesday, February 09 | 8:00AM - 11:15AM
Extracellular Matrix Composition and Stiffness in Regulation
of Cell Phenotype

Room: Grays/Longs Peak

Speaker 1 of 8
* Daniel Tschumperlin, Mayo Clinic, USA

Tuesday, February 09 | 8:00AM - 11:15AM
Extracellular Matrix Composition and Stiffness in Regulation
of Cell Phenotype

Room: Grays/Longs Peak

Speaker 2 of 8
* Dean Sheppard, University of California, San Francisco, USA

Tuesday, February 09 | 8:00AM - 11:15AM
Extracellular Matrix Composition and Stiffness in Regulation
of Cell Phenotype

Room: Grays/Longs Peak

Speaker 3 of 8
Dennis E. Discher, University of Pennsylvania, USA
Fractal Heterogeneity of Model Scars Modulates Stiff-Niche Stem-Cell Responses via Nuclear Exit of a Mechanorepressor

Tuesday, February 09 | 8:00AM - 11:15AM
Extracellular Matrix Composition and Stiffness in Regulation
of Cell Phenotype

Room: Grays/Longs Peak

Speaker 4 of 8
Peter Bitterman, University of Minnesota, USA
IPF Extracellular Matrix Activates a Profibrotic Feedback Loop by Deregulating MicroRNA-29 at a Post-Processing Step

Tuesday, February 09 | 8:00AM - 11:15AM
Extracellular Matrix Composition and Stiffness in Regulation
of Cell Phenotype

Room: Grays/Longs Peak

Speaker 5 of 8
Andrew M. Tager, Massachusetts General Hospital, USA
Mitochondrial Priming by Matrix Stiffness Sensitizes Myofibroblasts to BH3 Mimetic-induced Apoptosis in Scleroderma Fibrosis

Tuesday, February 09 | 8:00AM - 11:15AM
Extracellular Matrix Composition and Stiffness in Regulation
of Cell Phenotype

Room: Grays/Longs Peak

Speaker 6 of 8
Victoria Smith, Gilead Sciences, USA
Allosteric Targeting of LOXL2

Tuesday, February 09 | 8:00AM - 11:15AM
Extracellular Matrix Composition and Stiffness in Regulation
of Cell Phenotype

Room: Grays/Longs Peak

Speaker 7 of 8
Brendon M. Baker, Boston University, USA
Short Talk: Cell-Mediated Fiber Recruitment Drives Extracellular Matrix Mechanosensing in Engineered Fibrillar Microenvironments

Tuesday, February 09 | 8:00AM - 11:15AM
Extracellular Matrix Composition and Stiffness in Regulation
of Cell Phenotype

Room: Grays/Longs Peak

Speaker 8 of 8
Tanya Kalin, Cincinnati Children's Hospital Medical Center, USA
Short Talk: FoxF1 Inhibits Pulmonary Fibrosis by Preventing Differentiation of Normal Lung Fibroblasts into Myofibroblasts

Tuesday, February 09 | 8:00AM - 11:00AM
Stromal Cells in Lymphoid Development
This session is from Stromal Cells
Room: Quandary Peak

Speaker 1 of 5
Andrea Brendolan, Ospedale San Raffaele srl, Italy
Transcriptional Control of Retinoic Acid Metabolism in Stromal Progenitors is Required to Ensure Spleen Development


Tuesday, February 09 | 8:00AM - 11:00AM
Stromal Cells in Lymphoid Development
This session is from Stromal Cells
Room: Quandary Peak

Speaker 2 of 5
Marc Bajénoff, Centre d'Immunologie Marseille-Luminy, France
Dynamics of Lymphoid Stromal Cells


Tuesday, February 09 | 8:00AM - 11:00AM
Stromal Cells in Lymphoid Development
This session is from Stromal Cells
Room: Quandary Peak

Speaker 3 of 5
Yang-Xin Fu, University of Texas Southwestern Medical Center, USA
Targeting Tumor Stromal Microenvironment to Reprogram Tumor Immunity


Tuesday, February 09 | 8:00AM - 11:00AM
Stromal Cells in Lymphoid Development
This session is from Stromal Cells
Room: Quandary Peak

Speaker 4 of 5
* Jorge H. Caamano, College of Medicine - Univ. of Birmingham, UK
Development and function of Fat-Associated Lymphoid Clusters


Tuesday, February 09 | 8:00AM - 11:00AM
Stromal Cells in Lymphoid Development
This session is from Stromal Cells
Room: Quandary Peak

Speaker 5 of 5
Susan R. Schwab, New York University School of Medicine, USA
Short Talk: A Map of Sphingosine 1-Phosphate Distribution in the Spleen


Tuesday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 09 | 11:15AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Tuesday, February 09 | 11:15AM - 2:30PM
On Own for Lunch


Tuesday, February 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Assessing and Treating Human Fibrosis
Room: Grays/Longs Peak

Speaker 1 of 10
* Benjamin D. Humphreys, Washington University, USA

Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Assessing and Treating Human Fibrosis
Room: Grays/Longs Peak

Speaker 2 of 10
* David A. Schwartz, University of Colorado Denver, USA

Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Assessing and Treating Human Fibrosis
Room: Grays/Longs Peak

Speaker 3 of 10
Philip A. Waghorn, Martinos Biomedical Imaging Center, USA
Non-Invasive Imaging of Fibrogenesis using Magnetic Resonance Imaging (MRI)

Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Assessing and Treating Human Fibrosis
Room: Grays/Longs Peak

Speaker 4 of 10
Daryle J. DePianto, Genentech, Inc., USA
An in vitro Co-Culture System Recapitulating Epithelial-Mesenchymal Communication as a Tool for Investigating Mechanisms of IPF Pathogenesis

Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Assessing and Treating Human Fibrosis
Room: Grays/Longs Peak

Speaker 5 of 10
Alan C. Mullen, Harvard Medical School, USA
Long Noncoding RNAs Expressed in Human Hepatic Stellate Cells form Networks with Extracellular Matrix Proteins

Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Assessing and Treating Human Fibrosis
Room: Grays/Longs Peak

Speaker 6 of 10
Tatsuya Tsukui, University of California, San Francisco, USA
Intratracheal Cell Transfer Demonstrates the Profibrotic Potential of Resident Fibroblasts in Pulmonary Fibrosis

Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Assessing and Treating Human Fibrosis
Room: Grays/Longs Peak

Speaker 7 of 10
Shuyu Ren, USA
Multiple Domains of CTGF Amplify Pericyte Activation to Become Pathological Matrix Producing Cells

Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Assessing and Treating Human Fibrosis
Room: Grays/Longs Peak

Speaker 8 of 10
Claude Jourdan Le Saux, University of California, San Francisco, USA
Janus Kinase-1 Inhibitor Prevents Senescence in Mouse Lung Bleomycin Model Leading to Reduce Fibrosis

Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Assessing and Treating Human Fibrosis
Room: Grays/Longs Peak

Speaker 9 of 10
Resat Cinar, NIAAA, National Institutes of Health, USA
Improved Antifibrotic Efficacy and Safety of Hybrid Inhibitors of Peripheral CB1 Receptors and iNOS

Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Assessing and Treating Human Fibrosis
Room: Grays/Longs Peak

Speaker 10 of 10
Gerlinde Wernig, Institute for Regenerative Medicine and Stem Cell Research, USA
c-JUN is a Critical Mediator of Multi-Organ Fibrosis

Tuesday, February 09 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 09 | 5:00PM - 7:00PM
Adaptive Immunity, TH2 and IL-13 Fibrosis
Room: Grays/Longs Peak

Speaker 1 of 6
* Lucie Peduto, Institut Pasteur, France

Tuesday, February 09 | 5:00PM - 7:00PM
Adaptive Immunity, TH2 and IL-13 Fibrosis
Room: Grays/Longs Peak

Speaker 2 of 6
Cory M. Hogaboam, Cedars-Sinai Medical Center, USA
Features of Immune Deregulation in IPF

Tuesday, February 09 | 5:00PM - 7:00PM
Adaptive Immunity, TH2 and IL-13 Fibrosis
Room: Grays/Longs Peak

Speaker 3 of 6
* Thomas A. Wynn, Pfizer, USA

Tuesday, February 09 | 5:00PM - 7:00PM
Adaptive Immunity, TH2 and IL-13 Fibrosis
Room: Grays/Longs Peak

Speaker 4 of 6
Padraic Fallon, Trinity College Dublin, Ireland
Innate Lymphoid Cells and Fibrosis

Tuesday, February 09 | 5:00PM - 7:00PM
Adaptive Immunity, TH2 and IL-13 Fibrosis
Room: Grays/Longs Peak

Speaker 5 of 6
Joseph R. Arron, Genentech, Inc., USA
Targeting IL13 in Idiopathic Pulmonary Fibrosis

Tuesday, February 09 | 5:00PM - 7:00PM
Adaptive Immunity, TH2 and IL-13 Fibrosis
Room: Grays/Longs Peak

Speaker 6 of 6
Richard Lee Gieseck III, NIAID, National Institutes of Health, USA
Short Talk: IL-13 Drives Distinct Cellular Pathways Directing Biliary Proliferation, Steatosis, and Fibrosis

Tuesday, February 09 | 5:00PM - 7:00PM
Stromal Cell-Immune Cell Interactions in Non-Lymphoid Tissue
s
This session is from Stromal Cells

Room: Quandary Peak

Speaker 1 of 4
* Gwendalyn J. Randolph, Washington University, USA
Collecting Vessel Permeability and Fibrosis: Regulation by CCR7 and IRF4-Dependent Dendritic Cells


Tuesday, February 09 | 5:00PM - 7:00PM
Stromal Cell-Immune Cell Interactions in Non-Lymphoid Tissue
s
This session is from Stromal Cells

Room: Quandary Peak

Speaker 2 of 4
Scott N. Mueller, University of Melbourne, Australia
Dynamic Responses of Lymphoid Stromal Cells to Infection


Tuesday, February 09 | 5:00PM - 7:00PM
Stromal Cell-Immune Cell Interactions in Non-Lymphoid Tissue
s
This session is from Stromal Cells

Room: Quandary Peak

Speaker 3 of 4
* Andrea Cerutti, Mount Sinai School of Medicine, USA
Role of Stromal Cells in Innate-Like Antibody Responses


Tuesday, February 09 | 5:00PM - 7:00PM
Stromal Cell-Immune Cell Interactions in Non-Lymphoid Tissue
s
This session is from Stromal Cells

Room: Quandary Peak

Speaker 4 of 4
Joana Campos, University of Birmingham, UK
Short Talk: ICOS-ICOSL Interaction Regulates Lymphotoxin-alpha Expression and Maturation of Lymphoid-like Stromal Cells during Inflammation


Tuesday, February 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, February 09 | 7:30PM - 10:00PM
Poster Session 2
Room: Colorado Rockies Ballroom


Wednesday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Wednesday, February 10 | 8:00AM - 11:00AM
Perivascular Mesenchymal Cells and Vascular Niches: Versatil
e Cells in Health and Disease

Room: Grays/Longs Peak

Speaker 1 of 7
* Theresa T. Lu, Hospital for Special Surgery/Weill Cornell Medicine, USA

Wednesday, February 10 | 8:00AM - 11:00AM
Perivascular Mesenchymal Cells and Vascular Niches: Versatil
e Cells in Health and Disease

Room: Grays/Longs Peak

Speaker 2 of 7
* Jeremy S. Duffield, Vertex Pharmaceuticals, USA

Wednesday, February 10 | 8:00AM - 11:00AM
Perivascular Mesenchymal Cells and Vascular Niches: Versatil
e Cells in Health and Disease

Room: Grays/Longs Peak

Speaker 3 of 7
Lucie Peduto, Institut Pasteur, France
Perivascular Stromal Lineages in Fibrosis and Cancer

Wednesday, February 10 | 8:00AM - 11:00AM
Perivascular Mesenchymal Cells and Vascular Niches: Versatil
e Cells in Health and Disease

Room: Grays/Longs Peak

Speaker 4 of 7
Benjamin D. Humphreys, Washington University, USA
Mesenchymal Stem Cells in Organ Fibrosis

Wednesday, February 10 | 8:00AM - 11:00AM
Perivascular Mesenchymal Cells and Vascular Niches: Versatil
e Cells in Health and Disease

Room: Grays/Longs Peak

Speaker 5 of 7
Paul S. Frenette, Albert Einstein College of Medicine, USA
Mesenchymal Stromal Subsets and Vascular Niches in the Bone Marrow

Wednesday, February 10 | 8:00AM - 11:00AM
Perivascular Mesenchymal Cells and Vascular Niches: Versatil
e Cells in Health and Disease

Room: Grays/Longs Peak

Speaker 6 of 7
Lorin Olson, Oklahoma Medical Research Foundation, USA
Short Talk: Adipose Tissue Fibrosis Driven by PDGFRalpha-Induced Cell Fate Switch in Fibro-Adipogenic Progenitor Cells

Wednesday, February 10 | 8:00AM - 11:00AM
Perivascular Mesenchymal Cells and Vascular Niches: Versatil
e Cells in Health and Disease

Room: Grays/Longs Peak

Speaker 7 of 7
Irina Alexandra Leaf, Biogen, USA
Short Talk: Targeting MyD88-Dependent Signaling in Pericytes is Protective Against Tissue Injury and Fibrosis

Wednesday, February 10 | 8:00AM - 11:15AM
Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor
Immunity
This session is from Stromal Cells

Room: Quandary Peak

Speaker 1 of 6
* Melody A. Swartz, University of Chicago, USA
Immune Regulation by Tumor Lymphangiogenesis


Wednesday, February 10 | 8:00AM - 11:15AM
Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor
Immunity
This session is from Stromal Cells

Room: Quandary Peak

Speaker 2 of 6
Shannon J. Turley, Genentech, Inc., USA
Stromal Cell Coordination of Leukocyte Function and Spatiality


Wednesday, February 10 | 8:00AM - 11:15AM
Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor
Immunity
This session is from Stromal Cells

Room: Quandary Peak

Speaker 3 of 6
Karin Tarte, Université de Rennes 1 - U917 Inserm, France
Lymphoid Stromal Cells in B-Cell Lymphoma


Wednesday, February 10 | 8:00AM - 11:15AM
Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor
Immunity
This session is from Stromal Cells

Room: Quandary Peak

Speaker 4 of 6
* Thomas Blankenstein, Max Delbruck Center for Molecular Medicine, Germany
Adoptive T Cell Therapy


Wednesday, February 10 | 8:00AM - 11:15AM
Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor
Immunity
This session is from Stromal Cells

Room: Quandary Peak

Speaker 5 of 6
Jenny Rudnick, University of California, San Francisco, USA
Short Talk: Autophagy Regulates the Tumor Promoting State of Mammary Fibroblasts


Wednesday, February 10 | 8:00AM - 11:15AM
Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor
Immunity
This session is from Stromal Cells

Room: Quandary Peak

Speaker 6 of 6
Jacqui Shields, University of Cambridge, UK
Short Talk: Tumor-Associated Stromal Cells Contribute to Immune Dysfunction Via Antigen-specific Deletion of CD8+ T Cells and Transcriptional Reprogramming


Wednesday, February 10 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 10 | 11:00AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Wednesday, February 10 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, February 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Wednesday, February 10 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 10 | 5:00PM - 7:00PM
Fibrotic Muscle Disease
Room: Grays/Longs Peak

Speaker 1 of 5
* Paolo G. V. Martini, Moderna, USA

Wednesday, February 10 | 5:00PM - 7:00PM
Fibrotic Muscle Disease
Room: Grays/Longs Peak

Speaker 2 of 5
* Elisabeth Barton, University of Florida, USA
Fibrosis in Muscular Dystrophy

Wednesday, February 10 | 5:00PM - 7:00PM
Fibrotic Muscle Disease
Room: Grays/Longs Peak

Speaker 3 of 5
Bruce M. Wentworth, BMW Research Consulting, USA
Phosphorodiamidate Morpholino Oligomers (PMOs) in Development for the Treatment of Duchenne Muscular Dystrophy (DMD)

Wednesday, February 10 | 5:00PM - 7:00PM
Fibrotic Muscle Disease
Room: Grays/Longs Peak

Speaker 4 of 5
Barbora Malecova, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Single Cell Analysis Reveals Dynamic Transitions within Distinct Subpopulations of Fibro-Adipogenic Progenitors (FAPs) Implicated in Skeletal Muscle Regeneration or Fibrosis

Wednesday, February 10 | 5:00PM - 7:00PM
Fibrotic Muscle Disease
Room: Grays/Longs Peak

Speaker 5 of 5
Daniel Tschumperlin, Mayo Clinic, USA
Short Talk: RNAi Screening to Identify Genes Essential for Myofibroblast Activation

Wednesday, February 10 | 5:00PM - 7:00PM
Stromal Cell Function in Chronic Inflammation
This session is from Stromal Cells
Room: Quandary Peak

Speaker 1 of 4
* Michael B. Brenner, Harvard Medical School, USA
Targeting and Sub-setting Fibroblasts
to Treat Tissue Degradation and Fibrosis


Wednesday, February 10 | 5:00PM - 7:00PM
Stromal Cell Function in Chronic Inflammation
This session is from Stromal Cells
Room: Quandary Peak

Speaker 2 of 4
* Fiona M. Powrie, University of Oxford, UK
Innate Lymphoid Cells, Fibrosis and Inflammatory Bowel Disease


Wednesday, February 10 | 5:00PM - 7:00PM
Stromal Cell Function in Chronic Inflammation
This session is from Stromal Cells
Room: Quandary Peak

Speaker 3 of 4
Christopher D. Buckley, University of Birmingham, UK
The Role of Stromal Cells in Chronic Inflammation


Wednesday, February 10 | 5:00PM - 7:00PM
Stromal Cell Function in Chronic Inflammation
This session is from Stromal Cells
Room: Quandary Peak

Speaker 4 of 4
César Nombela-Arrieta, University Hospital Zurich, Switzerland
Short Talk: Chronic Viral Infections Induce Major Disruption of Bone Marrow Stromal Microarchitecture and Function


Wednesday, February 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, February 10 | 7:30PM - 10:00PM
Poster Session 3
Room: Colorado Rockies Ballroom


Thursday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Thursday, February 11 | 8:00AM - 11:15AM
Immunity in Fibrotic Diseases
Room: Grays/Longs Peak

Speaker 1 of 7
* Peter D. R. Higgins, University of Michigan, USA

Thursday, February 11 | 8:00AM - 11:15AM
Immunity in Fibrotic Diseases
Room: Grays/Longs Peak

Speaker 2 of 7
Ariel E. Feldstein, University of California, San Diego, USA
Inflammasome in Liver Fibrosis

Thursday, February 11 | 8:00AM - 11:15AM
Immunity in Fibrotic Diseases
Room: Grays/Longs Peak

Speaker 3 of 7
Florian Rieder, Cleveland Clinic, USA
Scarring in Inflammatory Bowel Disease

Thursday, February 11 | 8:00AM - 11:15AM
Immunity in Fibrotic Diseases
Room: Grays/Longs Peak

Speaker 4 of 7
Jaap M. Van Laar, UMC Utrecht, Netherlands
Stem Cell Transplant, Blocking Fibrosis in Systemic Sclerosis by Resetting the Immune System

Thursday, February 11 | 8:00AM - 11:15AM
Immunity in Fibrotic Diseases
Room: Grays/Longs Peak

Speaker 5 of 7
Rick Jack, Promedior, Inc., USA
PRM-151 (rhPTX-2) in Treating Fibrotic Diseases

Thursday, February 11 | 8:00AM - 11:15AM
Immunity in Fibrotic Diseases
Room: Grays/Longs Peak

Speaker 6 of 7
Ivan G. Gomez, Biogen, USA
Short Talk: TNF Superfamily Receptor Fn14 Activates Myofibroblasts to Drive Progression of Fibrotic Disease of the Kidney

Thursday, February 11 | 8:00AM - 11:15AM
Immunity in Fibrotic Diseases
Room: Grays/Longs Peak

Speaker 7 of 7
Boris Hinz, University of Toronto, Canada
Short Talk: Direct Adhesion of Macrophages Promotes Myofibroblast Differentiation by Establishing a Niche of Active TGF-Beta1

Thursday, February 11 | 8:00AM - 11:15AM
Stromal Cells in Immune Regulation, Tolerance and Autoimmuni
ty
This session is from Stromal Cells

Room: Quandary Peak

Speaker 1 of 6
Henrique Veiga-Fernandes, Champalimaud Research, Portugal
Environmental Sensing by Blood Cells


Thursday, February 11 | 8:00AM - 11:15AM
Stromal Cells in Immune Regulation, Tolerance and Autoimmuni
ty
This session is from Stromal Cells

Room: Quandary Peak

Speaker 2 of 6
* Jennifer L. Gommerman, University of Toronto, Canada
The Lymphotoxin Network and Stromal Cell Remodeling


Thursday, February 11 | 8:00AM - 11:15AM
Stromal Cells in Immune Regulation, Tolerance and Autoimmuni
ty
This session is from Stromal Cells

Room: Quandary Peak

Speaker 3 of 6
Ross M. Kedl, University of Colorado Denver, USA
Antigen Archiving by Lymph Node Stroma: A Novel Function for the Lymphatic Endothelium


Thursday, February 11 | 8:00AM - 11:15AM
Stromal Cells in Immune Regulation, Tolerance and Autoimmuni
ty
This session is from Stromal Cells

Room: Quandary Peak

Speaker 4 of 6
* Paul P. Tak, GlaxoSmithKline, UK
Towards Therapeutic Targeting of the Epigenome in Rheumatoid Arthritis


Thursday, February 11 | 8:00AM - 11:15AM
Stromal Cells in Immune Regulation, Tolerance and Autoimmuni
ty
This session is from Stromal Cells

Room: Quandary Peak

Speaker 5 of 6
Kaisa Auvinen, University of Turku, Finland
Short Talk: The Endothelial Protein PLVAP in Lymphatics Controls the Entry of Antigens into the Lymph Nodes


Thursday, February 11 | 8:00AM - 11:15AM
Stromal Cells in Immune Regulation, Tolerance and Autoimmuni
ty
This session is from Stromal Cells

Room: Quandary Peak

Speaker 6 of 6
Ivan Maillard, University of Michigan, USA
Short Talk: Stromal Cell Niches in Secondary Lymphoid Organs Drive T Cell Alloimmunity through Delta-Like1/4-Mediated Notch Signals


Thursday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 11 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, February 11 | 2:30PM - 4:30PM
Workshop 2
This session is from Stromal Cells
Room: Quandary Peak

Speaker 1 of 10
* Mark C. Coles, University of Oxford, UK


Thursday, February 11 | 2:30PM - 4:30PM
Workshop 2
This session is from Stromal Cells
Room: Quandary Peak

Speaker 2 of 10
* Sanjiv A. Luther, University of Lausanne, Switzerland


Thursday, February 11 | 2:30PM - 4:30PM
Workshop 2
This session is from Stromal Cells
Room: Quandary Peak

Speaker 3 of 10
Chris G. Mueller, University of Strasbourg, France
Distinct and Overlapping Roles of RANKL and Lymphotoxin in the Regulation of CD169+ Lymph Node Macrophages


Thursday, February 11 | 2:30PM - 4:30PM
Workshop 2
This session is from Stromal Cells
Room: Quandary Peak

Speaker 4 of 10
Rafael de Queiroz Prado, NIAID, National Institutes of Health, USA
Distinct Role for IL-4/IL-13 Activated Monocytes/Macrophages during Type 2 Cytokine-driven Pulmonary Fibrosis


Thursday, February 11 | 2:30PM - 4:30PM
Workshop 2
This session is from Stromal Cells
Room: Quandary Peak

Speaker 5 of 10
Lauren B. Rodda, University of Washington, USA
Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-expressing Reticular Cells


Thursday, February 11 | 2:30PM - 4:30PM
Workshop 2
This session is from Stromal Cells
Room: Quandary Peak

Speaker 6 of 10
Katarzyna Sitnik, Danish Technical University, Veterinary Institute, Denmark
Context Dependent Development of Lymphoid Stroma from BP3-PDPN+PDGFRalpha+/beta+CD34+ Adult Vascular Adventitial Cells


Thursday, February 11 | 2:30PM - 4:30PM
Workshop 2
This session is from Stromal Cells
Room: Quandary Peak

Speaker 7 of 10
Nathalie Steinthal, University of Birmingham, UK
Cd248 Plays an Important Role in Controlling the Differentiation of Mesenchymal Stem Cells to Adult Lymphoid Stromal Cells


Thursday, February 11 | 2:30PM - 4:30PM
Workshop 2
This session is from Stromal Cells
Room: Quandary Peak

Speaker 8 of 10
Seddon Thomas, NIEHS, National Institutes of Health, USA
Dendritic and Epithelial Cell Crosstalk in the Lung Orchestrates Immune Responses to Inhaled Allergens


Thursday, February 11 | 2:30PM - 4:30PM
Workshop 2
This session is from Stromal Cells
Room: Quandary Peak

Speaker 9 of 10
Carolyn A. Thomson, University of Glasgow, UK
Novel Insights into the Intestinal Stromal Cells Network, Revealed by Selective Expression of the Atypical Chemokine Receptor ACKR4


Thursday, February 11 | 2:30PM - 4:30PM
Workshop 2
This session is from Stromal Cells
Room: Quandary Peak

Speaker 10 of 10
Alice Anna Tomei, Diabetes Research Institute, USA
CCL21 Expression in Beta Cells Induces Lymph Node Mimicry in the Pancreas and Prevents Autoimmune Diabetes


Thursday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 11 | 5:00PM - 6:45PM
Emerging Antifibrotic Therapies
Room: Grays/Longs Peak

Speaker 1 of 4
* Lori Morton, Regeneron Pharmaceuticals, Inc., USA

Thursday, February 11 | 5:00PM - 6:45PM
Emerging Antifibrotic Therapies
Room: Grays/Longs Peak

Speaker 2 of 4
Dean Sheppard, University of California, San Francisco, USA
Integrin-Mediated TGFbeta Activation

Thursday, February 11 | 5:00PM - 6:45PM
Emerging Antifibrotic Therapies
Room: Grays/Longs Peak

Speaker 3 of 4
Luca Richeldi, University of Southampton, UK
Nintedanib

Thursday, February 11 | 5:00PM - 6:45PM
Emerging Antifibrotic Therapies
Room: Grays/Longs Peak

Speaker 4 of 4
Jörg H.W. Distler, University of Erlangen-Nuremberg, Germany
Upstream and Downstream Targeting of TGFbeta Signaling in Fibrosis

Thursday, February 11 | 5:00PM - 7:00PM
Therapeutic Application and Modulation of Stromal Cell Funct
ion
This session is from Stromal Cells

Room: Quandary Peak

Speaker 1 of 4
* Dhavalkumar D. Patel, UCB S.A., Belgium
Stromal-Immune Cell Cross-Talk in Autoimmune Disease: Roles in Therapeutic Interventions


Thursday, February 11 | 5:00PM - 7:00PM
Therapeutic Application and Modulation of Stromal Cell Funct
ion
This session is from Stromal Cells

Room: Quandary Peak

Speaker 2 of 4
Biju Parekkadan, Rutgers University, USA
Stromal Cell Therapy


Thursday, February 11 | 5:00PM - 7:00PM
Therapeutic Application and Modulation of Stromal Cell Funct
ion
This session is from Stromal Cells

Room: Quandary Peak

Speaker 3 of 4
* Katarina Le Blanc, Karolinska Institute, Sweden
Bringing Mesenchymal Stem Cells into the Clinic


Thursday, February 11 | 5:00PM - 7:00PM
Therapeutic Application and Modulation of Stromal Cell Funct
ion
This session is from Stromal Cells

Room: Quandary Peak

Speaker 4 of 4
Nisarg Shah, Harvard University, USA
Short Talk: Recapitulating the Bone Marrow Stroma to Drive Immune Reconstitution


Thursday, February 11 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grays/Longs Peak


Thursday, February 11 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Stromal Cells
Room: Quandary Peak

Speaker 1 of 2
Melody A. Swartz, University of Chicago, USA


Thursday, February 11 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Stromal Cells
Room: Quandary Peak

Speaker 2 of 2
Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland


Thursday, February 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, February 11 | 8:00PM - 11:00PM
Entertainment
Room: Colorado Rockies Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 11 | 8:00PM - 11:00PM
Cash Bar
Room: Colorado Rockies Ballroom


Friday, February 12 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.