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Stromal Cells in Immunity and Disease (2020Q5)

Web Desc
Stromal Cells in Immunity joint with Fibrosis: From Basic Mechanisms to Targeted Therapies Organizer(s): Shannon J. Turley, Burkhard Ludewig and Melody A. Swartz Date: February 07 - 11, 2016 Location: Keystone Resort, Keystone, CO, USA Sponsored by Genentech, Inc. For important information on the coronavirus, please click here Summary of Meeting: Within lymphoid organs, non-hematopoietic stromal cells organize and interact with leukocytes in immunologically important ways. In addition to organizing T and B cell segregation and expressing lymphocyte survival factors, stromal cells support the migration of and interactions between antigen-presenting cells and naïve T and B cells during the initiation of immune responses and influence the outcome between tolerance and immunity. Recent studies in rodents, non-human primates and humans have demonstrated that stromal cells also play instrumental roles in coordinating immune responses in non-lymphoid tissues, in inflammatory and autoimmune diseases and in chronic infection. Furthermore, stromal cells are being harnessed for therapeutic applications in a number of different clinical indications, an area that holds great promise for improving human health. Our understanding of stromal cell populations and their contributions to innate and adaptive immunity as well as immunological diseases, cancer and vaccination has grown exponentially over the past few years. This emerging field has gained enormous momentum due to highly sophisticated and in-depth efforts to dissect the fundamental biology and clinical importance of this cellular compartment. These critical advances as well as work that is on the cusp of being published or in the pipeline are the focus of this meeting. Scholarship Deadline: October 8 2015 Discounted Abstract Deadline: October 8 2015 Abstract Deadline: November 10 2015 Discounted Registration Deadline: December 8 2015 Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested. Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Novartis Institutes for BioMedical Research We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1R13AI122597-01 The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Stromal Cells in Immunity

joint with Fibrosis: From Basic Mechanisms to Targeted Therapies

Organizer(s): Shannon J. Turley, Burkhard Ludewig and Melody A. Swartz

Date: February 07 - 11, 2016
Location: Keystone Resort, Keystone, CO, USA

Program


Sunday, February 07 \| 4:00PM - 8:00PM Arrival and Registration Room: Longs Peak Foyer
Sunday, February 07 \| 6:00PM - 8:00PM Welcome Mixer Room: Longs Peak Foyer No registration fees are used to fund alcohol served at this function.
Monday, February 08 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Monday, February 08 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Columbine Ballroom Speaker 1 of 4 * Robert Lafyatis, University of Pittsburgh Medical Center, USA
Monday, February 08 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Columbine Ballroom Speaker 2 of 4 * Shannon J. Turley, Genentech, Inc., USA
Monday, February 08 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Columbine Ballroom Speaker 3 of 4 Ronald N. Germain, NIAID, National Institutes of Health, USA Imaging the Immune Cell–Stromal Interface in Lymphoid Tissues and Beyond
Monday, February 08 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Columbine Ballroom Speaker 4 of 4 Fiona M. Watt, King's College London School of Medicine, UK Contribution of Different Fibroblast Lineages to Skin Fibrosis
Monday, February 08 \| 9:30AM - 9:50AM Coffee Break Room: Longs Peak Foyer
Monday, February 08 \| 9:50AM - 12:00PM Stromal Cells in Inflammatory Disease (Joint) Room: Columbine Ballroom Speaker 1 of 5 * Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland Fibroblastric Reticular Cells: Phenotype Follows Function
Monday, February 08 \| 9:50AM - 12:00PM Stromal Cells in Inflammatory Disease (Joint) Room: Columbine Ballroom Speaker 2 of 5 Timothy W. Schacker, University of Minnesota, USA Lymphoid Tissue Fibrosis in HIV Infection
Monday, February 08 \| 9:50AM - 12:00PM Stromal Cells in Inflammatory Disease (Joint) Room: Columbine Ballroom Speaker 3 of 5 * Robert Lafyatis, University of Pittsburgh Medical Center, USA Dermal Fibroblast Heterogeneity and Fibrosis in Systemic Sclerosis
Monday, February 08 \| 9:50AM - 12:00PM Stromal Cells in Inflammatory Disease (Joint) Room: Columbine Ballroom Speaker 4 of 5 Mo Ebrahimkhani, Arizona State University, USA Short Talk: Engineering Human Organoids with Multiple Subsets of Stromal Cells
Monday, February 08 \| 9:50AM - 12:00PM Stromal Cells in Inflammatory Disease (Joint) Room: Columbine Ballroom Speaker 5 of 5 Jeffrey L. Browning, Boston University School of Medicine, USA Short Talk: Fibroblasts in the Skin of Systemic Sclerosis Patients Share Characteristics with FRC in Lymphoid Organs
Monday, February 08 \| 12:00PM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Monday, February 08 \| 12:00PM - 2:30PM On Own for Lunch
Monday, February 08 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1 Room: Quandary Peak Speaker 1 of 10 * Jeffrey L. Browning, Boston University School of Medicine, USA
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1 Room: Quandary Peak Speaker 2 of 10 * Shannon J. Turley, Genentech, Inc., USA
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1 Room: Quandary Peak Speaker 3 of 10 Florent Carrette, Sanford Burnham Prebys Medical Discovery Institute, USA CD44 is a New Immune Checkpoint that Promotes T Cell Exhaustion and Chronic Viral Infection through Expression on Fibroblastic Reticular Cells
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1 Room: Quandary Peak Speaker 4 of 10 Alice E. Denton, Babraham Institute, UK Lymph Node Stromal Cells Derive from a Distinct Embryonic FAP+ Progenitor
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1 Room: Quandary Peak Speaker 5 of 10 Juan Dubrot, Broad Institute, USA MHCII-mediated Antigen-presentation by Lymph Node Stromal Cells in Peripheral Tolerance
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1 Room: Quandary Peak Speaker 6 of 10 Henrike Fleige, Hannover Medical School, Germany The Role of Stromal Cells in Pathogen-induced BALT
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1 Room: Quandary Peak Speaker 7 of 10 Amanda Lund, New York University, USA Lymphatic Vessels are Required for Efficient Viral Clearance and Adaptive Immune Induction Following Epicutaneous Vaccinia Infection
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1 Room: Quandary Peak Speaker 8 of 10 Anna-Carin Andersson Lundell, Göteborg University, Sweden Type I and II Interferons Induce BAFF Production from Human Decidual Stromal Cells
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1 Room: Quandary Peak Speaker 9 of 10 Helen M. McGettrick, University of Birmingham, UK Identification of a Transitional Fibroblast Functional Phenotype in Early Rheumatoid Arthritis
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1 Room: Quandary Peak Speaker 10 of 10 Sarajo Mohanta, Ludwig-Maximilians University Munich, Germany Chameleons in the Arterial Wall: Vascular Smooth Muscle Cells Transdifferentiate into Lymphoid Tissue Organizer Cells and Control Atherosclerosis Immunity
Monday, February 08 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, February 08 \| 5:00PM - 7:15PM Stromal Cell Function in the Initiation of Adaptive Immunity Room: Quandary Peak Speaker 1 of 5 * Theresa T. Lu, Hospital for Special Surgery/Weill Cornell Medicine, USA Regulating Lymph Node Vascular-Stromal Growth and Survival in Immunity
Monday, February 08 \| 5:00PM - 7:15PM Stromal Cell Function in the Initiation of Adaptive Immunity Room: Quandary Peak Speaker 2 of 5 Antal Rot, University of York, UK Expression and Function of Atypical Chemokine Receptor 4 in Salivary Glands
Monday, February 08 \| 5:00PM - 7:15PM Stromal Cell Function in the Initiation of Adaptive Immunity Room: Quandary Peak Speaker 3 of 5 * Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA Lymph Node Fibroblast Reticular Cells in Regulation of Humoral Immunity
Monday, February 08 \| 5:00PM - 7:15PM Stromal Cell Function in the Initiation of Adaptive Immunity Room: Quandary Peak Speaker 4 of 5 Mark C. Coles, University of Oxford, UK Short Talk: Role of microRNA Mediated Stromal Remodeling in Vaccine Efficacy
Monday, February 08 \| 5:00PM - 7:15PM Stromal Cell Function in the Initiation of Adaptive Immunity Room: Quandary Peak Speaker 5 of 5 Sanjiv A. Luther, University of Lausanne, Switzerland Short Talk: Identification of a New Fibroblast Subset Forming Plasma Cell Survival Niches in Activated Lymph Nodes
Monday, February 08 \| 5:00PM - 7:00PM Metabolic Stress and Fibrogenesis This session is from Fibrosis Room: Grays/Longs Peak Speaker 1 of 6 * Mauricio Rojas, University of Pittsburgh, USA
Monday, February 08 \| 5:00PM - 7:00PM Metabolic Stress and Fibrogenesis This session is from Fibrosis Room: Grays/Longs Peak Speaker 2 of 6 * Maria Trojanowska, Boston University School of Medicine, USA
Monday, February 08 \| 5:00PM - 7:00PM Metabolic Stress and Fibrogenesis This session is from Fibrosis Room: Grays/Longs Peak Speaker 3 of 6 Timothy S. Blackwell, Vanderbilt University School of Medicine, USA ER Stress in Lung Fibrosis
Monday, February 08 \| 5:00PM - 7:00PM Metabolic Stress and Fibrogenesis This session is from Fibrosis Room: Grays/Longs Peak Speaker 4 of 6 Ana L. Mora, University of Pittsburgh, USA Fibrosis as a Disease of Aging and Mitochondrial Dysfunction
Monday, February 08 \| 5:00PM - 7:00PM Metabolic Stress and Fibrogenesis This session is from Fibrosis Room: Grays/Longs Peak Speaker 5 of 6 Philipp E. Scherer, University of Texas Southwestern Medical Center, USA Fat Inflammation, Fibrosis and Remodeling
Monday, February 08 \| 5:00PM - 7:00PM Metabolic Stress and Fibrogenesis This session is from Fibrosis Room: Grays/Longs Peak Speaker 6 of 6 Kamran Atabai, University of California, San Francisco, USA Short Talk: Functional Genomic Screen Identifies Novel Mediators of Collagen Uptake
Monday, February 08 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Monday, February 08 \| 7:30PM - 10:00PM Poster Session 1 Room: Colorado Rockies Ballroom
Tuesday, February 09 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Tuesday, February 09 \| 8:00AM - 11:00AM Stromal Cells in Lymphoid Development Room: Quandary Peak Speaker 1 of 5 Andrea Brendolan, Ospedale San Raffaele srl, Italy Transcriptional Control of Retinoic Acid Metabolism in Stromal Progenitors is Required to Ensure Spleen Development
Tuesday, February 09 \| 8:00AM - 11:00AM Stromal Cells in Lymphoid Development Room: Quandary Peak Speaker 2 of 5 Marc Bajénoff, Centre d'Immunologie Marseille-Luminy, France Dynamics of Lymphoid Stromal Cells
Tuesday, February 09 \| 8:00AM - 11:00AM Stromal Cells in Lymphoid Development Room: Quandary Peak Speaker 3 of 5 Yang-Xin Fu, University of Texas Southwestern Medical Center, USA Targeting Tumor Stromal Microenvironment to Reprogram Tumor Immunity
Tuesday, February 09 \| 8:00AM - 11:00AM Stromal Cells in Lymphoid Development Room: Quandary Peak Speaker 4 of 5 * Jorge H. Caamano, College of Medicine - Univ. of Birmingham, UK Development and function of Fat-Associated Lymphoid Clusters
Tuesday, February 09 \| 8:00AM - 11:00AM Stromal Cells in Lymphoid Development Room: Quandary Peak Speaker 5 of 5 Susan R. Schwab, New York University School of Medicine, USA Short Talk: A Map of Sphingosine 1-Phosphate Distribution in the Spleen
Tuesday, February 09 \| 8:00AM - 11:15AM Extracellular Matrix Composition and Stiffness in Regulation of Cell Phenotype This session is from Fibrosis Room: Grays/Longs Peak Speaker 1 of 8 * Daniel Tschumperlin, Mayo Clinic, USA
Tuesday, February 09 \| 8:00AM - 11:15AM Extracellular Matrix Composition and Stiffness in Regulation of Cell Phenotype This session is from Fibrosis Room: Grays/Longs Peak Speaker 2 of 8 * Dean Sheppard, University of California, San Francisco, USA
Tuesday, February 09 \| 8:00AM - 11:15AM Extracellular Matrix Composition and Stiffness in Regulation of Cell Phenotype This session is from Fibrosis Room: Grays/Longs Peak Speaker 3 of 8 Dennis E. Discher, University of Pennsylvania, USA Fractal Heterogeneity of Model Scars Modulates Stiff-Niche Stem-Cell Responses via Nuclear Exit of a Mechanorepressor
Tuesday, February 09 \| 8:00AM - 11:15AM Extracellular Matrix Composition and Stiffness in Regulation of Cell Phenotype This session is from Fibrosis Room: Grays/Longs Peak Speaker 4 of 8 Peter Bitterman, University of Minnesota, USA IPF Extracellular Matrix Activates a Profibrotic Feedback Loop by Deregulating MicroRNA-29 at a Post-Processing Step
Tuesday, February 09 \| 8:00AM - 11:15AM Extracellular Matrix Composition and Stiffness in Regulation of Cell Phenotype This session is from Fibrosis Room: Grays/Longs Peak Speaker 5 of 8 Andrew M. Tager, Massachusetts General Hospital, USA Mitochondrial Priming by Matrix Stiffness Sensitizes Myofibroblasts to BH3 Mimetic-induced Apoptosis in Scleroderma Fibrosis
Tuesday, February 09 \| 8:00AM - 11:15AM Extracellular Matrix Composition and Stiffness in Regulation of Cell Phenotype This session is from Fibrosis Room: Grays/Longs Peak Speaker 6 of 8 Victoria Smith, Gilead Sciences, USA Allosteric Targeting of LOXL2
Tuesday, February 09 \| 8:00AM - 11:15AM Extracellular Matrix Composition and Stiffness in Regulation of Cell Phenotype This session is from Fibrosis Room: Grays/Longs Peak Speaker 7 of 8 Brendon M. Baker, Boston University, USA Short Talk: Cell-Mediated Fiber Recruitment Drives Extracellular Matrix Mechanosensing in Engineered Fibrillar Microenvironments
Tuesday, February 09 \| 8:00AM - 11:15AM Extracellular Matrix Composition and Stiffness in Regulation of Cell Phenotype This session is from Fibrosis Room: Grays/Longs Peak Speaker 8 of 8 Tanya Kalin, Cincinnati Children's Hospital Medical Center, USA Short Talk: FoxF1 Inhibits Pulmonary Fibrosis by Preventing Differentiation of Normal Lung Fibroblasts into Myofibroblasts
Tuesday, February 09 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Tuesday, February 09 \| 11:15AM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Tuesday, February 09 \| 11:15AM - 5:00PM On Own for Lunch
Tuesday, February 09 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Assessing and Treating Human Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 1 of 10 * Benjamin D. Humphreys, Washington University, USA
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Assessing and Treating Human Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 2 of 10 * David A. Schwartz, University of Colorado Denver, USA
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Assessing and Treating Human Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 3 of 10 Philip A. Waghorn, Martinos Biomedical Imaging Center, USA Non-Invasive Imaging of Fibrogenesis using Magnetic Resonance Imaging (MRI)
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Assessing and Treating Human Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 4 of 10 Daryle J. DePianto, Genentech, Inc., USA An in vitro Co-Culture System Recapitulating Epithelial-Mesenchymal Communication as a Tool for Investigating Mechanisms of IPF Pathogenesis
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Assessing and Treating Human Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 5 of 10 Alan C. Mullen, Harvard Medical School, USA Long Noncoding RNAs Expressed in Human Hepatic Stellate Cells form Networks with Extracellular Matrix Proteins
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Assessing and Treating Human Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 6 of 10 Tatsuya Tsukui, University of California, San Francisco, USA Intratracheal Cell Transfer Demonstrates the Profibrotic Potential of Resident Fibroblasts in Pulmonary Fibrosis
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Assessing and Treating Human Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 7 of 10 Shuyu Ren, USA Multiple Domains of CTGF Amplify Pericyte Activation to Become Pathological Matrix Producing Cells
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Assessing and Treating Human Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 8 of 10 Claude Jourdan Le Saux, University of California, San Francisco, USA Janus Kinase-1 Inhibitor Prevents Senescence in Mouse Lung Bleomycin Model Leading to Reduce Fibrosis
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Assessing and Treating Human Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 9 of 10 Resat Cinar, NIAAA, National Institutes of Health, USA Improved Antifibrotic Efficacy and Safety of Hybrid Inhibitors of Peripheral CB1 Receptors and iNOS
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Assessing and Treating Human Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 10 of 10 Gerlinde Wernig, Institute for Regenerative Medicine and Stem Cell Research, USA c-JUN is a Critical Mediator of Multi-Organ Fibrosis
Tuesday, February 09 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, February 09 \| 5:00PM - 7:00PM Stromal Cell-Immune Cell Interactions in Non-Lymphoid Tissue s Room: Quandary Peak Speaker 1 of 4 * Gwendalyn J. Randolph, Washington University, USA Collecting Vessel Permeability and Fibrosis: Regulation by CCR7 and IRF4-Dependent Dendritic Cells
Tuesday, February 09 \| 5:00PM - 7:00PM Stromal Cell-Immune Cell Interactions in Non-Lymphoid Tissue s Room: Quandary Peak Speaker 2 of 4 Scott N. Mueller, University of Melbourne, Australia Dynamic Responses of Lymphoid Stromal Cells to Infection
Tuesday, February 09 \| 5:00PM - 7:00PM Stromal Cell-Immune Cell Interactions in Non-Lymphoid Tissue s Room: Quandary Peak Speaker 3 of 4 * Andrea Cerutti, Mount Sinai School of Medicine, USA Role of Stromal Cells in Innate-Like Antibody Responses
Tuesday, February 09 \| 5:00PM - 7:00PM Stromal Cell-Immune Cell Interactions in Non-Lymphoid Tissue s Room: Quandary Peak Speaker 4 of 4 Joana Campos, University of Birmingham, UK Short Talk: ICOS-ICOSL Interaction Regulates Lymphotoxin-alpha Expression and Maturation of Lymphoid-like Stromal Cells during Inflammation
Tuesday, February 09 \| 5:00PM - 7:00PM Adaptive Immunity, TH2 and IL-13 Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 1 of 6 * Lucie Peduto, Institut Pasteur, France
Tuesday, February 09 \| 5:00PM - 7:00PM Adaptive Immunity, TH2 and IL-13 Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 2 of 6 Cory M. Hogaboam, Cedars-Sinai Medical Center, USA Features of Immune Deregulation in IPF
Tuesday, February 09 \| 5:00PM - 7:00PM Adaptive Immunity, TH2 and IL-13 Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 3 of 6 * Thomas A. Wynn, Pfizer, USA
Tuesday, February 09 \| 5:00PM - 7:00PM Adaptive Immunity, TH2 and IL-13 Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 4 of 6 Padraic Fallon, Trinity College Dublin, Ireland Innate Lymphoid Cells and Fibrosis
Tuesday, February 09 \| 5:00PM - 7:00PM Adaptive Immunity, TH2 and IL-13 Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 5 of 6 Joseph R. Arron, Genentech, Inc., USA Targeting IL13 in Idiopathic Pulmonary Fibrosis
Tuesday, February 09 \| 5:00PM - 7:00PM Adaptive Immunity, TH2 and IL-13 Fibrosis This session is from Fibrosis Room: Grays/Longs Peak Speaker 6 of 6 Richard Lee Gieseck III, NIAID, National Institutes of Health, USA Short Talk: IL-13 Drives Distinct Cellular Pathways Directing Biliary Proliferation, Steatosis, and Fibrosis
Tuesday, February 09 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Tuesday, February 09 \| 7:30PM - 10:00PM Poster Session 2 Room: Colorado Rockies Ballroom
Wednesday, February 10 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Wednesday, February 10 \| 8:00AM - 11:15AM Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor Immunity Room: Quandary Peak Speaker 1 of 6 * Melody A. Swartz, University of Chicago, USA Immune Regulation by Tumor Lymphangiogenesis
Wednesday, February 10 \| 8:00AM - 11:15AM Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor Immunity Room: Quandary Peak Speaker 2 of 6 Shannon J. Turley, Genentech, Inc., USA Stromal Cell Coordination of Leukocyte Function and Spatiality
Wednesday, February 10 \| 8:00AM - 11:15AM Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor Immunity Room: Quandary Peak Speaker 3 of 6 Karin Tarte, Université de Rennes 1 - U917 Inserm, France Lymphoid Stromal Cells in B-Cell Lymphoma
Wednesday, February 10 \| 8:00AM - 11:15AM Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor Immunity Room: Quandary Peak Speaker 4 of 6 * Thomas Blankenstein, Max Delbruck Center for Molecular Medicine, Germany Adoptive T Cell Therapy
Wednesday, February 10 \| 8:00AM - 11:15AM Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor Immunity Room: Quandary Peak Speaker 5 of 6 Jenny Rudnick, University of California, San Francisco, USA Short Talk: Autophagy Regulates the Tumor Promoting State of Mammary Fibroblasts
Wednesday, February 10 \| 8:00AM - 11:15AM Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor Immunity Room: Quandary Peak Speaker 6 of 6 Jacqui Shields, University of Cambridge, UK Short Talk: Tumor-Associated Stromal Cells Contribute to Immune Dysfunction Via Antigen-specific Deletion of CD8+ T Cells and Transcriptional Reprogramming
Wednesday, February 10 \| 8:00AM - 11:00AM Perivascular Mesenchymal Cells and Vascular Niches: Versatil e Cells in Health and Disease This session is from Fibrosis Room: Grays/Longs Peak Speaker 1 of 7 * Theresa T. Lu, Hospital for Special Surgery/Weill Cornell Medicine, USA
Wednesday, February 10 \| 8:00AM - 11:00AM Perivascular Mesenchymal Cells and Vascular Niches: Versatil e Cells in Health and Disease This session is from Fibrosis Room: Grays/Longs Peak Speaker 2 of 7 * Jeremy S. Duffield, Vertex Pharmaceuticals, USA
Wednesday, February 10 \| 8:00AM - 11:00AM Perivascular Mesenchymal Cells and Vascular Niches: Versatil e Cells in Health and Disease This session is from Fibrosis Room: Grays/Longs Peak Speaker 3 of 7 Lucie Peduto, Institut Pasteur, France Perivascular Stromal Lineages in Fibrosis and Cancer
Wednesday, February 10 \| 8:00AM - 11:00AM Perivascular Mesenchymal Cells and Vascular Niches: Versatil e Cells in Health and Disease This session is from Fibrosis Room: Grays/Longs Peak Speaker 4 of 7 Benjamin D. Humphreys, Washington University, USA Mesenchymal Stem Cells in Organ Fibrosis
Wednesday, February 10 \| 8:00AM - 11:00AM Perivascular Mesenchymal Cells and Vascular Niches: Versatil e Cells in Health and Disease This session is from Fibrosis Room: Grays/Longs Peak Speaker 5 of 7 Paul S. Frenette, Albert Einstein College of Medicine, USA Mesenchymal Stromal Subsets and Vascular Niches in the Bone Marrow
Wednesday, February 10 \| 8:00AM - 11:00AM Perivascular Mesenchymal Cells and Vascular Niches: Versatil e Cells in Health and Disease This session is from Fibrosis Room: Grays/Longs Peak Speaker 6 of 7 Lorin Olson, Oklahoma Medical Research Foundation, USA Short Talk: Adipose Tissue Fibrosis Driven by PDGFRalpha-Induced Cell Fate Switch in Fibro-Adipogenic Progenitor Cells
Wednesday, February 10 \| 8:00AM - 11:00AM Perivascular Mesenchymal Cells and Vascular Niches: Versatil e Cells in Health and Disease This session is from Fibrosis Room: Grays/Longs Peak Speaker 7 of 7 Irina Alexandra Leaf, Biogen, USA Short Talk: Targeting MyD88-Dependent Signaling in Pericytes is Protective Against Tissue Injury and Fibrosis
Wednesday, February 10 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Wednesday, February 10 \| 11:15AM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Wednesday, February 10 \| 11:15AM - 5:00PM On Own for Lunch
Wednesday, February 10 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Wednesday, February 10 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, February 10 \| 5:00PM - 7:00PM Stromal Cell Function in Chronic Inflammation Room: Quandary Peak Speaker 1 of 4 * Michael B. Brenner, Harvard Medical School, USA Targeting and Sub-setting Fibroblasts to Treat Tissue Degradation and Fibrosis
Wednesday, February 10 \| 5:00PM - 7:00PM Stromal Cell Function in Chronic Inflammation Room: Quandary Peak Speaker 2 of 4 * Fiona M. Powrie, University of Oxford, UK Innate Lymphoid Cells, Fibrosis and Inflammatory Bowel Disease
Wednesday, February 10 \| 5:00PM - 7:00PM Stromal Cell Function in Chronic Inflammation Room: Quandary Peak Speaker 3 of 4 Christopher D. Buckley, University of Birmingham, UK The Role of Stromal Cells in Chronic Inflammation
Wednesday, February 10 \| 5:00PM - 7:00PM Stromal Cell Function in Chronic Inflammation Room: Quandary Peak Speaker 4 of 4 César Nombela-Arrieta, University Hospital Zurich, Switzerland Short Talk: Chronic Viral Infections Induce Major Disruption of Bone Marrow Stromal Microarchitecture and Function
Wednesday, February 10 \| 5:00PM - 7:00PM Fibrotic Muscle Disease This session is from Fibrosis Room: Grays/Longs Peak Speaker 1 of 5 * Paolo G. V. Martini, Moderna, USA
Wednesday, February 10 \| 5:00PM - 7:00PM Fibrotic Muscle Disease This session is from Fibrosis Room: Grays/Longs Peak Speaker 2 of 5 * Elisabeth Barton, University of Florida, USA Fibrosis in Muscular Dystrophy
Wednesday, February 10 \| 5:00PM - 7:00PM Fibrotic Muscle Disease This session is from Fibrosis Room: Grays/Longs Peak Speaker 3 of 5 Bruce M. Wentworth, BMW Research Consulting, USA Phosphorodiamidate Morpholino Oligomers (PMOs) in Development for the Treatment of Duchenne Muscular Dystrophy (DMD)
Wednesday, February 10 \| 5:00PM - 7:00PM Fibrotic Muscle Disease This session is from Fibrosis Room: Grays/Longs Peak Speaker 4 of 5 Barbora Malecova, Sanford Burnham Prebys Medical Discovery Institute, USA Short Talk: Single Cell Analysis Reveals Dynamic Transitions within Distinct Subpopulations of Fibro-Adipogenic Progenitors (FAPs) Implicated in Skeletal Muscle Regeneration or Fibrosis
Wednesday, February 10 \| 5:00PM - 7:00PM Fibrotic Muscle Disease This session is from Fibrosis Room: Grays/Longs Peak Speaker 5 of 5 Daniel Tschumperlin, Mayo Clinic, USA Short Talk: RNAi Screening to Identify Genes Essential for Myofibroblast Activation
Wednesday, February 10 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Wednesday, February 10 \| 7:30PM - 10:00PM Poster Session 3 Room: Colorado Rockies Ballroom
Thursday, February 11 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Thursday, February 11 \| 8:00AM - 11:15AM Stromal Cells in Immune Regulation, Tolerance and Autoimmuni ty Room: Quandary Peak Speaker 1 of 6 Henrique Veiga-Fernandes, Champalimaud Research, Portugal Environmental Sensing by Blood Cells
Thursday, February 11 \| 8:00AM - 11:15AM Stromal Cells in Immune Regulation, Tolerance and Autoimmuni ty Room: Quandary Peak Speaker 2 of 6 * Jennifer L. Gommerman, University of Toronto, Canada The Lymphotoxin Network and Stromal Cell Remodeling
Thursday, February 11 \| 8:00AM - 11:15AM Stromal Cells in Immune Regulation, Tolerance and Autoimmuni ty Room: Quandary Peak Speaker 3 of 6 Ross M. Kedl, University of Colorado Denver, USA Antigen Archiving by Lymph Node Stroma: A Novel Function for the Lymphatic Endothelium
Thursday, February 11 \| 8:00AM - 11:15AM Stromal Cells in Immune Regulation, Tolerance and Autoimmuni ty Room: Quandary Peak Speaker 4 of 6 * Paul P. Tak, GlaxoSmithKline, UK Towards Therapeutic Targeting of the Epigenome in Rheumatoid Arthritis
Thursday, February 11 \| 8:00AM - 11:15AM Stromal Cells in Immune Regulation, Tolerance and Autoimmuni ty Room: Quandary Peak Speaker 5 of 6 Kaisa Auvinen, University of Turku, Finland Short Talk: The Endothelial Protein PLVAP in Lymphatics Controls the Entry of Antigens into the Lymph Nodes
Thursday, February 11 \| 8:00AM - 11:15AM Stromal Cells in Immune Regulation, Tolerance and Autoimmuni ty Room: Quandary Peak Speaker 6 of 6 Ivan Maillard, University of Michigan, USA Short Talk: Stromal Cell Niches in Secondary Lymphoid Organs Drive T Cell Alloimmunity through Delta-Like1/4-Mediated Notch Signals
Thursday, February 11 \| 8:00AM - 11:15AM Immunity in Fibrotic Diseases This session is from Fibrosis Room: Grays/Longs Peak Speaker 1 of 7 * Peter D. R. Higgins, University of Michigan, USA
Thursday, February 11 \| 8:00AM - 11:15AM Immunity in Fibrotic Diseases This session is from Fibrosis Room: Grays/Longs Peak Speaker 2 of 7 Ariel E. Feldstein, University of California, San Diego, USA Inflammasome in Liver Fibrosis
Thursday, February 11 \| 8:00AM - 11:15AM Immunity in Fibrotic Diseases This session is from Fibrosis Room: Grays/Longs Peak Speaker 3 of 7 Florian Rieder, Cleveland Clinic, USA Scarring in Inflammatory Bowel Disease
Thursday, February 11 \| 8:00AM - 11:15AM Immunity in Fibrotic Diseases This session is from Fibrosis Room: Grays/Longs Peak Speaker 4 of 7 Jaap M. Van Laar, UMC Utrecht, Netherlands Stem Cell Transplant, Blocking Fibrosis in Systemic Sclerosis by Resetting the Immune System
Thursday, February 11 \| 8:00AM - 11:15AM Immunity in Fibrotic Diseases This session is from Fibrosis Room: Grays/Longs Peak Speaker 5 of 7 Rick Jack, Promedior, Inc., USA PRM-151 (rhPTX-2) in Treating Fibrotic Diseases
Thursday, February 11 \| 8:00AM - 11:15AM Immunity in Fibrotic Diseases This session is from Fibrosis Room: Grays/Longs Peak Speaker 6 of 7 Ivan G. Gomez, Biogen, USA Short Talk: TNF Superfamily Receptor Fn14 Activates Myofibroblasts to Drive Progression of Fibrotic Disease of the Kidney
Thursday, February 11 \| 8:00AM - 11:15AM Immunity in Fibrotic Diseases This session is from Fibrosis Room: Grays/Longs Peak Speaker 7 of 7 Boris Hinz, University of Toronto, Canada Short Talk: Direct Adhesion of Macrophages Promotes Myofibroblast Differentiation by Establishing a Niche of Active TGF-Beta1
Thursday, February 11 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Thursday, February 11 \| 11:15AM - 2:30PM On Own for Lunch
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 2 Room: Quandary Peak Speaker 1 of 10 * Mark C. Coles, University of Oxford, UK
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 2 Room: Quandary Peak Speaker 2 of 10 * Sanjiv A. Luther, University of Lausanne, Switzerland
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 2 Room: Quandary Peak Speaker 3 of 10 Chris G. Mueller, University of Strasbourg, France Distinct and Overlapping Roles of RANKL and Lymphotoxin in the Regulation of CD169+ Lymph Node Macrophages
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 2 Room: Quandary Peak Speaker 4 of 10 Rafael de Queiroz Prado, NIAID, National Institutes of Health, USA Distinct Role for IL-4/IL-13 Activated Monocytes/Macrophages during Type 2 Cytokine-driven Pulmonary Fibrosis
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 2 Room: Quandary Peak Speaker 5 of 10 Lauren B. Rodda, University of Washington, USA Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-expressing Reticular Cells
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 2 Room: Quandary Peak Speaker 6 of 10 Katarzyna Sitnik, Danish Technical University, Veterinary Institute, Denmark Context Dependent Development of Lymphoid Stroma from BP3-PDPN+PDGFRalpha+/beta+CD34+ Adult Vascular Adventitial Cells
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 2 Room: Quandary Peak Speaker 7 of 10 Nathalie Steinthal, University of Birmingham, UK Cd248 Plays an Important Role in Controlling the Differentiation of Mesenchymal Stem Cells to Adult Lymphoid Stromal Cells
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 2 Room: Quandary Peak Speaker 8 of 10 Seddon Thomas, NIEHS, National Institutes of Health, USA Dendritic and Epithelial Cell Crosstalk in the Lung Orchestrates Immune Responses to Inhaled Allergens
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 2 Room: Quandary Peak Speaker 9 of 10 Carolyn A. Thomson, University of Glasgow, UK Novel Insights into the Intestinal Stromal Cells Network, Revealed by Selective Expression of the Atypical Chemokine Receptor ACKR4
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 2 Room: Quandary Peak Speaker 10 of 10 Alice Anna Tomei, Diabetes Research Institute, USA CCL21 Expression in Beta Cells Induces Lymph Node Mimicry in the Pancreas and Prevents Autoimmune Diabetes
Thursday, February 11 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, February 11 \| 5:00PM - 7:00PM Therapeutic Application and Modulation of Stromal Cell Funct ion Room: Quandary Peak Speaker 1 of 4 * Dhavalkumar D. Patel, UCB S.A., Belgium Stromal-Immune Cell Cross-Talk in Autoimmune Disease: Roles in Therapeutic Interventions
Thursday, February 11 \| 5:00PM - 7:00PM Therapeutic Application and Modulation of Stromal Cell Funct ion Room: Quandary Peak Speaker 2 of 4 Biju Parekkadan, Rutgers University, USA Stromal Cell Therapy
Thursday, February 11 \| 5:00PM - 7:00PM Therapeutic Application and Modulation of Stromal Cell Funct ion Room: Quandary Peak Speaker 3 of 4 * Katarina Le Blanc, Karolinska Institute, Sweden Bringing Mesenchymal Stem Cells into the Clinic
Thursday, February 11 \| 5:00PM - 7:00PM Therapeutic Application and Modulation of Stromal Cell Funct ion Room: Quandary Peak Speaker 4 of 4 Nisarg Shah, Harvard University, USA Short Talk: Recapitulating the Bone Marrow Stroma to Drive Immune Reconstitution
Thursday, February 11 \| 5:00PM - 6:45PM Emerging Antifibrotic Therapies This session is from Fibrosis Room: Grays/Longs Peak Speaker 1 of 4 * Lori Morton, Regeneron Pharmaceuticals, Inc., USA
Thursday, February 11 \| 5:00PM - 6:45PM Emerging Antifibrotic Therapies This session is from Fibrosis Room: Grays/Longs Peak Speaker 2 of 4 Dean Sheppard, University of California, San Francisco, USA Integrin-Mediated TGFbeta Activation
Thursday, February 11 \| 5:00PM - 6:45PM Emerging Antifibrotic Therapies This session is from Fibrosis Room: Grays/Longs Peak Speaker 3 of 4 Luca Richeldi, University of Southampton, UK Nintedanib
Thursday, February 11 \| 5:00PM - 6:45PM Emerging Antifibrotic Therapies This session is from Fibrosis Room: Grays/Longs Peak Speaker 4 of 4 Jörg H.W. Distler, University of Erlangen-Nuremberg, Germany Upstream and Downstream Targeting of TGFbeta Signaling in Fibrosis
Thursday, February 11 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) This session is from Fibrosis Room: Grays/Longs Peak
Thursday, February 11 \| 7:00PM - 7:15PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Quandary Peak Speaker 1 of 2 Melody A. Swartz, University of Chicago, USA
Thursday, February 11 \| 7:00PM - 7:15PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Quandary Peak Speaker 2 of 2 Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland
Thursday, February 11 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Thursday, February 11 \| 8:00PM - 11:00PM Entertainment Room: Colorado Rockies Ballroom Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, February 11 \| 8:00PM - 11:00PM Cash Bar Room: Colorado Rockies Ballroom
Friday, February 12 \| 10:23AM - 10:23AM Departure *Session Chair †Invited, not yet responded.