Web Desc
Enhancer Malfunction in Cancer
joint with Noncoding RNAs in Health and Disease
Organizer(s): Ali Shilatifard and Dale Dorsett
Date: February 21 - 24, 2016
Location: Santa Fe Community Convention Center, Santa Fe, NM, USA
Supported by the Directors' Fund
Summary of Meeting:
Why point mutations in a general transcription factor are associated with specific forms of human malignancies has been a major question in cancer biology. Enhancers are DNA regulatory elements that can be transcribed and are key regulators of tissue-specific gene expression in development; their malfunction through point mutations in either regulatory elements or factors modulating enhancer-promoter communication could result in development problems. Indeed, recent genome-wide studies in the cataloging of somatic mutations in cancer have identified mutations in intergenic sequences encoding regulatory elements and in specific transcription factors that function in enhancer-promoter communication. This Keystone Symposia meeting will review recent reports in this regard and discuss the concept of enhancer malfunction in the misregulation of gene expression in development and in disease pathogenesis.
Scholarship Deadline: October 20 2015
Discounted Abstract Deadline: October 20 2015
Abstract Deadline: November 18 2015
Discounted Registration Deadline: December 18 2015
We gratefully acknowledge additional support for this conference from:
Dharmacon, part of GE Healthcare
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

EMBO Young Investigator Programme
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA200208-01
Funding for this conference was made possible (in part) by 1R13CA200208-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, February 21 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sweeney Ballroom Foyer


Sunday, February 21 | 6:00PM - 8:00PM
Welcome Mixer
Room: Sweeney F
No registration fees are used to fund alcohol served at this function.

Monday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Monday, February 22 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 4
Eric N. Olson, University of Texas Southwestern Medical Center, USA
Modulation of Muscle Development and Disease by Noncoding RNAs

Monday, February 22 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 4
Michael S. Levine, Princeton University, USA
Enhancers/Promoters and Regulation of Gene Expression

Monday, February 22 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 4
* Ramin Shiekhattar, University of Miami, USA

Monday, February 22 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 4
* Ali Shilatifard, Northwestern University, USA

Monday, February 22 | 9:30AM - 9:50AM
Coffee Break
Room: Lobby


Monday, February 22 | 9:50AM - 11:45AM
Noncoding RNAs in Heterochromatin and Dosage Compensation
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 5 of 5
Montserrat Anguera, University of Pennsylvania, USA
Short Talk: Unusual Maintenance of X-Chromosome Inactivation Predisposes Female Lymphocytes for Increased Expression from the Inactive X


Monday, February 22 | 9:50AM - 11:45AM
Noncoding RNAs in Heterochromatin and Dosage Compensation
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
RNA Processing Machineries in Gene Silencing


Monday, February 22 | 9:50AM - 11:45AM
Noncoding RNAs in Heterochromatin and Dosage Compensation
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 3 of 5
Joshua T. Mendell, University of Texas Southwestern Medical Center, USA
Regulation of Genomic Stability by the Noncoding RNA NORAD


Monday, February 22 | 9:50AM - 11:45AM
Noncoding RNAs in Heterochromatin and Dosage Compensation
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 2 of 5
Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs


Monday, February 22 | 9:50AM - 11:45AM
Noncoding RNAs in Heterochromatin and Dosage Compensation
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* François Fuks, Université Libre de Bruxelles, Belgium


Monday, February 22 | 9:50AM - 12:00PM
Enhancer Biology
Room: Sweeney Ballroom C-E

Speaker 6 of 6
Beatriz Aranda-Orgilles, NYU School of Medicine, USA
Short Talk: Med12 Regulates Enhancer Dynamics in HSCs Independently of Mediator Kinase Activity

Monday, February 22 | 9:50AM - 12:00PM
Enhancer Biology
Room: Sweeney Ballroom C-E

Speaker 5 of 6
Julie Ahringer, University of Cambridge, UK
Short Talk: Properties and Activities of Enhancers

Monday, February 22 | 9:50AM - 12:00PM
Enhancer Biology
Room: Sweeney Ballroom C-E

Speaker 4 of 6
Alexander Stark, Research Institute of Molecular Pathology - IMP, Austria
EMBO Young Investigator Lecture: Decoding Transcriptional Regulation

Monday, February 22 | 9:50AM - 12:00PM
Enhancer Biology
Room: Sweeney Ballroom C-E

Speaker 3 of 6
Matthias Merkenschlager, Imperial College London, UK
The contribution of cohesin to enhancer connectivity and function.

Monday, February 22 | 9:50AM - 12:00PM
Enhancer Biology
Room: Sweeney Ballroom C-E

Speaker 2 of 6
Dale Dorsett, St. Louis University School of Medicine, USA
RNA Binding Proteins Aid Association of Cohesin with Genes and Enhancers

Monday, February 22 | 9:50AM - 12:00PM
Enhancer Biology
Room: Sweeney Ballroom C-E

Speaker 1 of 6
* Gerd A. Blobel, Children's Hospital of Philadelphia, USA

Monday, February 22 | 12:00PM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakouts


Monday, February 22 | 12:00PM - 4:00PM
On Own for Lunch


Monday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakouts


Monday, February 22 | 4:00PM - 7:00PM
Noncoding RNAs and Enhancers in Development (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 7
* Luciano Di Croce, CRG - Center for Genomic Regulation, Spain

Monday, February 22 | 4:00PM - 4:50PM
Small Noncoding RNA in Transcriptional Silencing (Joint)
Room: Sweeney Ballroom A-E


Monday, February 22 | 4:00PM - 7:00PM
Noncoding RNAs and Enhancers in Development (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 7
Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Noncoding RNAs and Transposition

Monday, February 22 | 4:00PM - 7:00PM
Noncoding RNAs and Enhancers in Development (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 7
Anindya Dutta, University of Virginia, USA
Short Talk: MUNC and DRAIC: lncRNAs Involved in Differentiation and in Repression of Metastasis

Monday, February 22 | 4:00PM - 7:00PM
Noncoding RNAs and Enhancers in Development (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 7
Robin D. Dowell, University of Colorado, USA
Enhancer RNAs Originate from Active Transcription Factor Binding

Monday, February 22 | 4:00PM - 7:00PM
Noncoding RNAs and Enhancers in Development (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 7
Gioacchino Natoli, Humanitas University, Italy
Noncoding Transcription at Enhancers and Promoters: Genome-Wide Suppression by Early Termination

Monday, February 22 | 4:00PM - 7:00PM
Noncoding RNAs and Enhancers in Development (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 7
Gerd A. Blobel, Children's Hospital of Philadelphia, USA
A Hyperactive Transcriptional State Marks Genome Reactivation during Mitotic Exit

Monday, February 22 | 4:00PM - 7:00PM
Noncoding RNAs and Enhancers in Development (Joint)
Room: Sweeney Ballroom A-E

Speaker 7 of 7
* Panagiotis Ntziachristos, Northwestern University, USA
Short Talk: Characterization of the Oncogenic Enhancer Repertoire in T Cell Leukemia using Chromatin Conformation Studies

Monday, February 22 | 5:30PM - 5:50PM
Coffee Break
Room: Lobby


Monday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts
No registration fees are used to fund alcohol served at this function.

Monday, February 22 | 7:30PM - 10:00PM
Poster Session 1
Room: Sweeney F, Main Level Breakouts


Tuesday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Tuesday, February 23 | 8:00AM - 11:15AM
Enhancer RNAs in Development and Disease (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 8
* Anne Brunet, Stanford University, USA

Tuesday, February 23 | 8:00AM - 11:15AM
Enhancer RNAs in Development and Disease (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 8
* Julie Ahringer, University of Cambridge, UK

Tuesday, February 23 | 8:00AM - 11:15AM
Enhancer RNAs in Development and Disease (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 8
Ramin Shiekhattar, University of Miami, USA
Biogenesis and Mechanism of Action of Enhancer RNAs

Tuesday, February 23 | 8:00AM - 11:15AM
Enhancer RNAs in Development and Disease (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 8
Shelley L. Berger, University of Pennsylvania, USA
CBP Senses its Transcription Environment at Enhancers to Locally Modulate Acetyltransferase Activity

Tuesday, February 23 | 8:00AM - 11:15AM
Enhancer RNAs in Development and Disease (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 8
Christopher K. Glass, University of California, San Diego, USA
Mechanisms and Consequences of Enhancer Transcription

Tuesday, February 23 | 8:00AM - 11:15AM
Enhancer RNAs in Development and Disease (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 8
Tae-Kyung Kim, University of Texas Southwestern Medical Center, USA
Functional Mechanisms of Neuronal Enhancers

Tuesday, February 23 | 8:00AM - 11:15AM
Enhancer RNAs in Development and Disease (Joint)
Room: Sweeney Ballroom A-E

Speaker 7 of 8
Franziska Petermann, NIAMS, National Institutes of Health, USA
Short Talk: Deletion of NeST Reduces IFN-gamma Expression and Chromosomal Looping at the Ifng locus

Tuesday, February 23 | 8:00AM - 11:15AM
Enhancer RNAs in Development and Disease (Joint)
Room: Sweeney Ballroom A-E

Speaker 8 of 8
Daniel R. Larson, NCI, National Institutes of Health, USA
Short Talk: Coordinate Regulation of Estrogen-Responsive Genes and eRNA in Single Cells

Tuesday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Lobby


Tuesday, February 23 | 11:15AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakouts


Tuesday, February 23 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, February 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakouts


Tuesday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Lobby


Tuesday, February 23 | 5:00PM - 7:00PM
Enhancer Chromatin and Noncoding RNAs (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 6
* Karen Adelman, Harvard Medical School, USA

Tuesday, February 23 | 5:00PM - 7:00PM
Enhancer Chromatin and Noncoding RNAs (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 6
* Dale Dorsett, St. Louis University School of Medicine, USA

Tuesday, February 23 | 5:00PM - 7:00PM
Enhancer Chromatin and Noncoding RNAs (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 6
Ali Shilatifard, Northwestern University, USA
Enhancer Malfunction in Cancer

Tuesday, February 23 | 5:00PM - 7:00PM
Enhancer Chromatin and Noncoding RNAs (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 6
Tony Kouzarides, University of Cambridge, UK
Role of ncRNAs in Transcription and Cancer

Tuesday, February 23 | 5:00PM - 7:00PM
Enhancer Chromatin and Noncoding RNAs (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 6
Harinder Singh, Cincinnati Children's Hospital Medical Center, USA
Single-Cell Analysis of Mixed-Lineage Transcriptional States Leading to a Binary Cell Fate Choice

Tuesday, February 23 | 5:00PM - 7:00PM
Enhancer Chromatin and Noncoding RNAs (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 6
Jesse M. Engreitz, Harvard University and Broad Institute, USA
Short Talk: Many Promoters of lncRNAs and mRNAs Act as Enhancers in Local Gene Regulatory Networks

Tuesday, February 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts
No registration fees are used to fund alcohol served at this function.

Tuesday, February 23 | 7:30PM - 10:00PM
Poster Session 2
Room: Sweeney F, Main Level Breakouts


Wednesday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Wednesday, February 24 | 8:00AM - 11:00AM
Enhancers and Regulatory Networks
Room: Sweeney Ballroom C-E

Speaker 1 of 6
* Dale Dorsett, St. Louis University School of Medicine, USA

Wednesday, February 24 | 8:00AM - 11:00AM
Enhancers and Regulatory Networks
Room: Sweeney Ballroom C-E

Speaker 2 of 6
Ann Dean, NIDDK, National Institutes of Health, USA
Enhancer Mechanisms Underlying the Erythroid Transcriptome

Wednesday, February 24 | 8:00AM - 11:00AM
Enhancers and Regulatory Networks
Room: Sweeney Ballroom C-E

Speaker 3 of 6
Warren S. Pear, University of Pennsylvania, USA
Modular Domains within a Super Enhancer Determine Drug Resistance in T-Cell Leukemia

Wednesday, February 24 | 8:00AM - 11:00AM
Enhancers and Regulatory Networks
Room: Sweeney Ballroom C-E

Speaker 4 of 6
W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Molecular Mechanisms for the Assembly and Function of Cell Type-Specific Enhancers

Wednesday, February 24 | 8:00AM - 11:00AM
Enhancers and Regulatory Networks
Room: Sweeney Ballroom C-E

Speaker 5 of 6
Denes Hnisz, Whitehead Institute, USA
Enhancer Structure and Function in Health and Disease


Wednesday, February 24 | 8:00AM - 11:00AM
Enhancers and Regulatory Networks
Room: Sweeney Ballroom C-E

Speaker 6 of 6
Sarah C. Pyfrom, Washington University in St. Louis, USA
Short Talk: Defining and Targeting Pathogenic Enhancers in B Cell Cancers

Wednesday, February 24 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetics
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 1 of 7
* Roberto Bonasio, University of Pennsylvania, USA


Wednesday, February 24 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetics
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 2 of 7
François Fuks, Université Libre de Bruxelles, Belgium
Mechanisms of TETs and Hydroxymethylation


Wednesday, February 24 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetics
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 3 of 7
Anne Brunet, Stanford University, USA
Epigenetic Regulation of Longevity


Wednesday, February 24 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetics
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 4 of 7
Chris Marine, VIB-KU Leuven, Belgium
Cancer Cell Addiction to lncRNAs


Wednesday, February 24 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetics
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 5 of 7
Gozde Korkmaz, Netherlands Cancer Institute, Netherlands
Short Talk: Functional Genetic Screens for Enhancer Elements in the Human Genome Using CRISPR-Cas9


Wednesday, February 24 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetics
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 6 of 7
Luciano Di Croce, CRG - Center for Genomic Regulation, Spain
Polycomb Orchestrates Gene Regulation Dynamics in Cell Differentiation and Cancer


Wednesday, February 24 | 8:00AM - 11:15AM
Noncoding RNAs in Epigenetics
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 7 of 7
Madoka Chinen, NIDDK, National Institutes of Health, USA
Short Talk: Structure-Function Analysis of Drosophila Argonaute2 in Chromatin Insulator Activity


Wednesday, February 24 | 9:20AM - 9:40AM
Coffee Break
Room: Lobby


Wednesday, February 24 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, February 24 | 4:30PM - 5:00PM
Coffee Available
Room: Lobby


Wednesday, February 24 | 5:00PM - 7:00PM
Chromatin Structure and Enhancer Promoter Communications
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Ann Dean, NIDDK, National Institutes of Health, USA

Wednesday, February 24 | 5:00PM - 7:00PM
Chromatin Structure and Enhancer Promoter Communications
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Nadav Ahituv, University of California, San Francisco, USA
Functional Characterization of Gene Regulatory Elements

Wednesday, February 24 | 5:00PM - 7:00PM
Chromatin Structure and Enhancer Promoter Communications
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Robert E. Kingston, Massachusetts General Hospital, USA
Alterations in Nucleosome Accessibility during Regulation

Wednesday, February 24 | 5:00PM - 7:00PM
Chromatin Structure and Enhancer Promoter Communications
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Blaine Bartholomew, University of Texas MD Anderson Cancer Center, USA
Short Talk: Auto-Regulation of SWI/SNF in Cancer and its Relationship to Enhancers

Wednesday, February 24 | 5:00PM - 7:00PM
Chromatin Structure and Enhancer Promoter Communications
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Sharon Y.R. Dent, University of Texas MD Anderson Cancer Center, USA
Short Talk: A SAGA of GCN5 and USP22 in Development and Disease

Wednesday, February 24 | 5:00PM - 7:00PM
Noncoding RNAs and Nuclear Architecture
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Howard Y. Chang, Stanford University, USA


Wednesday, February 24 | 5:00PM - 7:00PM
Noncoding RNAs and Nuclear Architecture
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 2 of 5
John L. Rinn, University of Colorado Boulder, USA
Function and Evolution of Local Repeats in the FIRRE Locus


Wednesday, February 24 | 5:00PM - 7:00PM
Noncoding RNAs and Nuclear Architecture
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 3 of 5
Eric A.J. Simko, Johns Hopkins University, USA
Short Talk: Nuclear Paraspeckle Disruption by C9orf72 Repeat RNA


Wednesday, February 24 | 5:00PM - 7:00PM
Noncoding RNAs and Nuclear Architecture
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Karen Adelman, Harvard Medical School, USA
Pol II Pausing and Elongation at Noncoding RNA Loci


Wednesday, February 24 | 5:00PM - 7:00PM
Noncoding RNAs and Nuclear Architecture
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 5 of 5
Roberto Bonasio, University of Pennsylvania, USA
RNA-Mediated Regulation of Chromatin-Associated Proteins


Wednesday, February 24 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Sweeney Ballroom C-E


Wednesday, February 24 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 1 of 2
* Ramin Shiekhattar, University of Miami, USA


Wednesday, February 24 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
This session is from Noncoding RNAs
Room: Sweeney Ballroom A-B

Speaker 2 of 2
* Roberto Bonasio, University of Pennsylvania, USA


Wednesday, February 24 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts
No registration fees are used to fund alcohol served at this function.

Wednesday, February 24 | 8:00PM - 11:00PM
Entertainment
Room: Sweeney F, Main Level Breakouts
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Wednesday, February 24 | 8:00PM - 11:00PM
Cash Bar
Room: Sweeney F, Main Level Breakouts


Thursday, February 25 | 10:25AM - 10:25AM
Departure


*Session Chair.