Web Desc
Immunometabolism in Immune Function and Inflammatory Disease
joint with New Frontiers in Understanding Tumor Metabolism
Organizer(s): Jeffrey C. Rathmell, Jonathan D. Powell and Amira Klip
Date: February 21 - 25, 2016
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by AbbVie Inc., Abide Therapeutics Inc., Astellas Pharma Inc. and Boehringer Ingelheim Pharmaceuticals, Inc.
Summary of Meeting:
It is now evident that an integral component of immune regulation is through the metabolic pathways necessary to support energetically demanding protective or pathogenic responses. Deciphering these links in the emerging field of immunometabolism is critical to understanding basic immune function. Activation, differentiation and function of M1 & M2 macrophages, Th1, Th2, Th17 & T regulatory T cells as well as effector and memory CD8+ T cells are all inexorably linked to pathways that regulate cellular metabolism. Likewise, systemic metabolism and metabolic diseases are very much influenced by immunity, as the metabolic syndrome in obesity is mediated in part by dysregulated immune cells similar to inflammatory and autoimmune disease states. This meeting addresses how immune cells and functions rely upon and are controlled by specific metabolic pathways and nutrient availability and will bridge systemic and cellular metabolic regulation of immune function. Metabolic reprogramming in the activation of adaptive and innate immune cells and the regulation and role of specific metabolic programs in distinct lymphocyte or macrophage subsets will be addressed. The conference will also present new findings on signaling pathways and the influence of immune cell metabolism on anti-tumor immunity, autoimmunity and metabolic diseases. It is anticipated this meeting will be of broad interest to the immunology and metabolic communities. The focus of this meeting on how factors that influence immune cell metabolism impact a variety of inflammatory disorders will provide new fundamental insight into normal immune function as well as opportunities to treat immunological and metabolic diseases.
Scholarship Deadline: October 22 2015
Discounted Abstract Deadline: October 22 2015
Abstract Deadline: November 23 2015
Discounted Registration Deadline: December 21 2015
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AbbVie Inc.Abide Therapeutics Inc.Astellas Pharma Inc.Boehringer Ingelheim Pharmaceuticals, Inc.
We gratefully acknowledge additional support for this conference from:
Adipogen International
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI122337-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 21 | 4:00PM - 8:00PM
Arrival and Registration
Room: Van Horne Foyer


Sunday, February 21 | 6:00PM - 8:00PM
Welcome Mixer
Room: Van Horne Foyer
No registration fees are used to fund alcohol served at this function.

Monday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Monday, February 22 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 1 of 4
* Chi Van Dang, University of Pennsylvania, USA

Monday, February 22 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 2 of 4
* Jeffrey C. Rathmell, Vanderbilt University, USA

Monday, February 22 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 3 of 4
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Metabolic Reprogramming as a Driver of Macrophage-Mediated Inflammation

Monday, February 22 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Van Horne A/B

Speaker 4 of 4
Joan S. Brugge, Harvard Medical School, USA
Computational Analysis of Genetic and Phenotypic Contributions to Metabolic Gene Expression in Cancer

Monday, February 22 | 9:30AM - 9:50AM
Coffee Break
Room: Van Horne Foyer


Monday, February 22 | 9:50AM - 12:00PM
Metabolic Basis for Cell Proliferation and Regulation (Joint
)

Room: Van Horne A/B

Speaker 1 of 7
* Chi Van Dang, University of Pennsylvania, USA

Monday, February 22 | 9:50AM - 12:00PM
Metabolic Basis for Cell Proliferation and Regulation (Joint
)

Room: Van Horne A/B

Speaker 2 of 7
* Jeffrey C. Rathmell, Vanderbilt University, USA

Monday, February 22 | 9:50AM - 12:00PM
Metabolic Basis for Cell Proliferation and Regulation (Joint
)

Room: Van Horne A/B

Speaker 3 of 7
Michael Karin, University of California, San Diego, USA
Signaling in Inflammatory Pathways

Monday, February 22 | 9:50AM - 12:00PM
Metabolic Basis for Cell Proliferation and Regulation (Joint
)

Room: Van Horne A/B

Speaker 4 of 7
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Metabolic Adaptation in Cancer Cells: Exploiting Cancer Metabolic Vulnerabilities

Monday, February 22 | 9:50AM - 12:00PM
Metabolic Basis for Cell Proliferation and Regulation (Joint
)

Room: Van Horne A/B

Speaker 5 of 7
Lewis C. Cantley, Weill Cornell Medicine, USA
PI3K and Cancer Metabolism

Monday, February 22 | 9:50AM - 12:00PM
Metabolic Basis for Cell Proliferation and Regulation (Joint
)

Room: Van Horne A/B

Speaker 6 of 7
Mark A. Febbraio, Monash Institute of Pharmaceutical Sciences, Australia
Short Talk: The Chameleon Role TLR4 in Lipid-Induced Macrophage Inflammation

Monday, February 22 | 9:50AM - 12:00PM
Metabolic Basis for Cell Proliferation and Regulation (Joint
)

Room: Van Horne A/B

Speaker 7 of 7
Thomas G. Graeber, University of California, Los Angeles, USA
Short Talk: Recurrent Patterns of DNA Copy Number Alterations in Tumors Reflect Metabolic Selection Pressures

Monday, February 22 | 12:00PM - 1:00PM
Poster Setup
Room: Mezzanine 2


Monday, February 22 | 12:00PM - 2:30PM
On Own for Lunch


Monday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: Metabolism of Lymphocytes
Room: Van Horne C

Speaker 1 of 10
* Christoph Hess, University Hospital Basel/University of Cambridge, Switzerland

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: Metabolism of Lymphocytes
Room: Van Horne C

Speaker 2 of 10
* Laurence Morel, University of Florida, USA

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: Metabolism of Lymphocytes
Room: Van Horne C

Speaker 3 of 10
Brian M. Iritani, University of Washington, USA
Metabolic Control of Peripheral B Lymphocyte Development and Homeostasis by the AMPK-Interacting Protein Fnip1

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: Metabolism of Lymphocytes
Room: Van Horne C

Speaker 4 of 10
Linda V. Sinclair, University of Dundee, UK
Antigen Receptor Control of Methionine Metabolism

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: Metabolism of Lymphocytes
Room: Van Horne C

Speaker 5 of 10
Michael Buck, Max Planck Institute of Immunobiology and Epigenetics, Germany
Promoting CD8 T Cell Memory through Mitochondrial Dynamics

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: Metabolism of Lymphocytes
Room: Van Horne C

Speaker 6 of 10
Eric H. Ma, McGill University, Canada
Investigating the Role of Serine Metabolism for T Cell Proliferation and Function

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: Metabolism of Lymphocytes
Room: Van Horne C

Speaker 7 of 10
Lelisa F. Gemta, University of Virginia, USA
Metabolism as a Functional Constraint of Tumor Infiltrating CD8+ T Cells

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: Metabolism of Lymphocytes
Room: Van Horne C

Speaker 8 of 10
David C. Clever, National Institutes of Health, USA
T Cell Oxygen Sensing Suppresses Pulmonary Effector Responses and Licenses Lung Tumor Metastasis

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: Metabolism of Lymphocytes
Room: Van Horne C

Speaker 9 of 10
Nancie J. MacIver, Duke University School of Medicine, USA
Leptin Directly Promotes T Cell Glycolytic Metabolism to Drive Th17 Differentiation

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: Metabolism of Lymphocytes
Room: Van Horne C

Speaker 10 of 10
Dan Wu, University of British Columbia, Canada
Adipocytes Promote Regulatory T Cell Metabolism and Function

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: New Concepts
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 1 of 9
* Joshua D. Rabinowitz, Princeton University, USA


Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: New Concepts
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 2 of 9
Michael Aregger, University of Toronto, Canada
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities


Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: New Concepts
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 3 of 9
Thales Papagiannakopoulos, New York University School of Medicine, USA
Dissecting the Role of Aberrant Oxidative Homeostasis in Lung Cancer


Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: New Concepts
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 4 of 9
Kivanc Birsoy, Rockefeller University, USA
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis


Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: New Concepts
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 5 of 9
Lucas B. Sullivan, Fred Hutchinson Cancer Research Center, USA
Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells


Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: New Concepts
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 6 of 9
Kevin Marks, Agios Pharmaceuticals, USA
Metabolite Accumulation in MTAP-Deficient Cancers Creates Targetable Collateral Vulnerabilities


Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: New Concepts
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 7 of 9
Zachary Bacigalupa, Vanderbilt University Medical Center, USA
Role of OGT and O-GlcNAcylation in Glioblastoma Lipid Metabolism and Growth


Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: New Concepts
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 8 of 9
Brooke M. Emerling, Sanford Burnham Prebys Medical Discovery Institute, USA
Phosphatidylinositol-5-Phosphate 4-Kinases Are Essential for Survival during Metabolic Stress


Monday, February 22 | 2:30PM - 4:30PM
Workshop 1: New Concepts
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 9 of 9
Sun Mi Hong, Pohang University of Science and Technology, POSTECH, South Korea
NAMPT Regulates Metabolic Stress in Cancer Progression by Maintaining NADPH Levels


Monday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Monday, February 22 | 5:00PM - 7:00PM
Metabolic Regulation of Macrophage Function
Room: Van Horne C
The goals of this plenary session are to discuss the role of metabolic reprogramming and altered metabolism in macrophage activation and inflammatory function.
Speaker 1 of 5
* Mark A. Febbraio, Monash Institute of Pharmaceutical Sciences, Australia

Monday, February 22 | 5:00PM - 7:00PM
Metabolic Regulation of Macrophage Function
Room: Van Horne C
The goals of this plenary session are to discuss the role of metabolic reprogramming and altered metabolism in macrophage activation and inflammatory function.
Speaker 2 of 5
Ajay Chawla, Merck Research Labs, USA
Innate Control of Adipose Tissue Metabolism

Monday, February 22 | 5:00PM - 7:00PM
Metabolic Regulation of Macrophage Function
Room: Van Horne C
The goals of this plenary session are to discuss the role of metabolic reprogramming and altered metabolism in macrophage activation and inflammatory function.
Speaker 3 of 5
Anthony W. Ferrante, Columbia University, USA
Metabolic Diseases and Macrophage Populations

Monday, February 22 | 5:00PM - 7:00PM
Metabolic Regulation of Macrophage Function
Room: Van Horne C
The goals of this plenary session are to discuss the role of metabolic reprogramming and altered metabolism in macrophage activation and inflammatory function.
Speaker 4 of 5
Amira Klip, Hospital for Sick Children, Canada
Crosstalk between Muscle and Macrophages

Monday, February 22 | 5:00PM - 7:00PM
Metabolic Regulation of Macrophage Function
Room: Van Horne C
The goals of this plenary session are to discuss the role of metabolic reprogramming and altered metabolism in macrophage activation and inflammatory function.
Speaker 5 of 5
Oscar R. Colegio, Yale University, USA
Short Talk: Tumor-Derived Lactic Acid Functionally Polarizes Tumor-Associated Macrophages

Monday, February 22 | 5:00PM - 7:15PM
Fundamentals of Cell Metabolism: Metabolic Wiring and in viv
o Studies
This session is from Tumor Metabolism

Room: Van Horne A/B

Speaker 1 of 5
* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA


Monday, February 22 | 5:00PM - 7:15PM
Fundamentals of Cell Metabolism: Metabolic Wiring and in viv
o Studies
This session is from Tumor Metabolism

Room: Van Horne A/B

Speaker 2 of 5
Joshua D. Rabinowitz, Princeton University, USA
Quantitative Analysis of Metabolic Activity.


Monday, February 22 | 5:00PM - 7:15PM
Fundamentals of Cell Metabolism: Metabolic Wiring and in viv
o Studies
This session is from Tumor Metabolism

Room: Van Horne A/B

Speaker 3 of 5
Christian Metallo, University of California, San Diego, USA
Understanding and Exploiting Metabolic Flexibility in Human Cells


Monday, February 22 | 5:00PM - 7:15PM
Fundamentals of Cell Metabolism: Metabolic Wiring and in viv
o Studies
This session is from Tumor Metabolism

Room: Van Horne A/B

Speaker 4 of 5
Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Understanding Metabolic Heterogeneity in Human Cancer Cells and Tumors


Monday, February 22 | 5:00PM - 7:15PM
Fundamentals of Cell Metabolism: Metabolic Wiring and in viv
o Studies
This session is from Tumor Metabolism

Room: Van Horne A/B

Speaker 5 of 5
Teresa W. M. Fan, University of Kentucky Markey Cancer Center, USA
Exploring Lung Cancer Metabolome: In vivo and ex vivo


Monday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Monday, February 22 | 7:30PM - 10:00PM
Poster Session 1
Room: Mezzanine 2


Tuesday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Tuesday, February 23 | 8:00AM - 11:15AM
Effector and Regulatory T Cell Metabolism and Function
Room: Van Horne C
The goals of this session are to discuss T cell subsets and how metabolic signaling and environment affect subset establishment and selection.
Speaker 1 of 7
* Richard M. Siegel, NIAMS, National Institutes of Health, USA

Tuesday, February 23 | 8:00AM - 11:15AM
Effector and Regulatory T Cell Metabolism and Function
Room: Van Horne C
The goals of this session are to discuss T cell subsets and how metabolic signaling and environment affect subset establishment and selection.
Speaker 2 of 7
Jeffrey C. Rathmell, Vanderbilt University, USA
Glucose Uptake and Fueling T Cell Immunity

Tuesday, February 23 | 8:00AM - 11:15AM
Effector and Regulatory T Cell Metabolism and Function
Room: Van Horne C
The goals of this session are to discuss T cell subsets and how metabolic signaling and environment affect subset establishment and selection.
Speaker 3 of 7
Hongbo Chi, St. Jude Children's Research Hospital, USA
Interplay between Immune Signaling and Cell Metabolism in Effector and Treg Cells

Tuesday, February 23 | 8:00AM - 11:15AM
Effector and Regulatory T Cell Metabolism and Function
Room: Van Horne C
The goals of this session are to discuss T cell subsets and how metabolic signaling and environment affect subset establishment and selection.
Speaker 4 of 7
Steven J. Bensinger, University of California, Los Angeles, USA
Towards Understanding the Importance of Sterol Metabolism in Host Defense

Tuesday, February 23 | 8:00AM - 11:15AM
Effector and Regulatory T Cell Metabolism and Function
Room: Van Horne C
The goals of this session are to discuss T cell subsets and how metabolic signaling and environment affect subset establishment and selection.
Speaker 5 of 7
Laurence A. Turka, Rheos Medicines, USA
Regulatory T Cell Metabolism - Does Form Affect Function?

Tuesday, February 23 | 8:00AM - 11:15AM
Effector and Regulatory T Cell Metabolism and Function
Room: Van Horne C
The goals of this session are to discuss T cell subsets and how metabolic signaling and environment affect subset establishment and selection.
Speaker 6 of 7
Sam Weinberg, Northwestern University, USA
Short Talk: Mitochondrial Complex III is Required Regulatory T Cell Function

Tuesday, February 23 | 8:00AM - 11:15AM
Effector and Regulatory T Cell Metabolism and Function
Room: Van Horne C
The goals of this session are to discuss T cell subsets and how metabolic signaling and environment affect subset establishment and selection.
Speaker 7 of 7
Nicholas R. J. Gascoigne, National University of Singapore and Scripps Research, Singapore
Short Talk: T-Cell-Specific Signaling Molecule Themis in T Cell Metabolism, Obesity, and Type 2 Diabetes

Tuesday, February 23 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 1 of 7
* Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA


Tuesday, February 23 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 2 of 7
M. Celeste Simon, University of Pennsylvania, USA
Hypoxia, Metabolism and Renal Cancer


Tuesday, February 23 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 3 of 7
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Angiogenesis Revisited: Role and (Therapeutic) Implications of Endothelial Metabolism


Tuesday, February 23 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 4 of 7
Reuben J. Shaw, The Salk Institute for Biological Studies, USA
The LKB1 – AMPK Pathway: Metabolic Rewiring and Therapeutic Targeting


Tuesday, February 23 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 5 of 7
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Insights from Metabolism Studies in Mouse Cancer Models


Tuesday, February 23 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 6 of 7
Sarah-Maria Fendt, VIB Leuven, Belgium
Short Talk: Breast Cancer Cells Depend on ATP Production from Proline Catabolism during Metastatic Colonization


Tuesday, February 23 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 7 of 7
Guido T. Bommer, Universite Catholique de Louvain, Belgium
Short Talk: Identification of a Multi-Functional Enzyme Protecting Glycolysis and the Pentose Phosphate Pathway from Metabolic Side-Products


Tuesday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Tuesday, February 23 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Tuesday, February 23 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, February 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Tuesday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, February 23 | 5:00PM - 7:00PM
The AMPK/mTOR Axis in Metabolism, Inflammation and Immunity
Room: Van Horne C
The goal of this plenary session is to discuss the role of signaling through the mTOR pathway in immune cell metabolism and function.
Speaker 1 of 5
* David K. Finlay, Trinity Biomedical Sciences Institute, Ireland

Tuesday, February 23 | 5:00PM - 7:00PM
The AMPK/mTOR Axis in Metabolism, Inflammation and Immunity
Room: Van Horne C
The goal of this plenary session is to discuss the role of signaling through the mTOR pathway in immune cell metabolism and function.
Speaker 2 of 5
Russell G. Jones, Van Andel Research Institute, USA
LKB1: Links between Inflammation and Tumor Development

Tuesday, February 23 | 5:00PM - 7:00PM
The AMPK/mTOR Axis in Metabolism, Inflammation and Immunity
Room: Van Horne C
The goal of this plenary session is to discuss the role of signaling through the mTOR pathway in immune cell metabolism and function.
Speaker 3 of 5
Jonathan D. Powell, Johns Hopkins University School of Medicine, USA
Targeting mTOR and Metabolism as a Means of Regulating T Cell Activation, Differentiation and Function

Tuesday, February 23 | 5:00PM - 7:00PM
The AMPK/mTOR Axis in Metabolism, Inflammation and Immunity
Room: Van Horne C
The goal of this plenary session is to discuss the role of signaling through the mTOR pathway in immune cell metabolism and function.
Speaker 4 of 5
Tiffany Horng, ShanghaiTech University, China
Metabolic Calibration of Macrophage Activation

Tuesday, February 23 | 5:00PM - 7:00PM
The AMPK/mTOR Axis in Metabolism, Inflammation and Immunity
Room: Van Horne C
The goal of this plenary session is to discuss the role of signaling through the mTOR pathway in immune cell metabolism and function.
Speaker 5 of 5
Mark R. Boothby, Vanderbilt University Medical Center, USA
Short Talk: Hypoxia Suppresses Amino Acid Uptake and mTORC1 Activity, Causing Altered Class Switch Biases and Attenuation of Antibody Responses

Tuesday, February 23 | 5:00PM - 7:15PM
Oncogenes and Tumor Suppressors and Metabolism
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 1 of 6
* Navdeep S. Chandel, Northwestern University, USA


Tuesday, February 23 | 5:00PM - 7:15PM
Oncogenes and Tumor Suppressors and Metabolism
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 2 of 6
Robert N. Eisenman, Fred Hutchinson Cancer Research Center, USA
Transcriptional Regulation by the MAX-Like Protein MLX is Required for Increased Metabolic Demand Associated with Tumorigenesis and Spermatogenesis


Tuesday, February 23 | 5:00PM - 7:15PM
Oncogenes and Tumor Suppressors and Metabolism
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 3 of 6
Mariia Yuneva, Francis Crick Institute, UK
Metabolic Lessons Learned from in vivo Tumor Models


Tuesday, February 23 | 5:00PM - 7:15PM
Oncogenes and Tumor Suppressors and Metabolism
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 4 of 6
Karen H. Vousden, Francis Crick Institute, UK
One Carbon Metabolism and Cancer


Tuesday, February 23 | 5:00PM - 7:15PM
Oncogenes and Tumor Suppressors and Metabolism
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 5 of 6
Don Ayer, University of Utah, USA
Short Talk: c-Myc and MondoA Couple Nutrient Utilization and Availability in Tumorigenesis


Tuesday, February 23 | 5:00PM - 7:15PM
Oncogenes and Tumor Suppressors and Metabolism
This session is from Tumor Metabolism
Room: Van Horne A/B
Transcriptional Regulation of Metabolism
Speaker 6 of 6
Zhimin Lu, University of Texas MD Anderson Cancer Center, USA
Short Talk: The Unique Features of Liver Tumor Cell Metabolism


Tuesday, February 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Tuesday, February 23 | 7:30PM - 10:00PM
Poster Session 2
Room: Mezzanine 2


Wednesday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Wednesday, February 24 | 8:00AM - 11:15AM
Metabolism of Inflammation and Innate Immune Responses
Room: Van Horne C
The goal of this plenary session is to discuss how metabolic pathways link inflammation and innate immune cells.
Speaker 1 of 7
* Tiffany Horng, ShanghaiTech University, China

Wednesday, February 24 | 8:00AM - 11:15AM
Metabolism of Inflammation and Innate Immune Responses
Room: Van Horne C
The goal of this plenary session is to discuss how metabolic pathways link inflammation and innate immune cells.
Speaker 2 of 7
Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Pathways in Effector and Memory T Cells

Wednesday, February 24 | 8:00AM - 11:15AM
Metabolism of Inflammation and Innate Immune Responses
Room: Van Horne C
The goal of this plenary session is to discuss how metabolic pathways link inflammation and innate immune cells.
Speaker 3 of 7
Helen C. Su, NIAID, National Institutes of Health, USA
Proteolysis and Metabolism in Human Immunodeficiency

Wednesday, February 24 | 8:00AM - 11:15AM
Metabolism of Inflammation and Innate Immune Responses
Room: Van Horne C
The goal of this plenary session is to discuss how metabolic pathways link inflammation and innate immune cells.
Speaker 4 of 7
Melinda A. Beck, University of North Carolina, USA
Viral Infection and Metabolism

Wednesday, February 24 | 8:00AM - 11:15AM
Metabolism of Inflammation and Innate Immune Responses
Room: Van Horne C
The goal of this plenary session is to discuss how metabolic pathways link inflammation and innate immune cells.
Speaker 5 of 7
Richard M. Siegel, NIAMS, National Institutes of Health, USA
Fueling the Fire: Mitochondria and Metabolism in Autoinflammatory Disease

Wednesday, February 24 | 8:00AM - 11:15AM
Metabolism of Inflammation and Innate Immune Responses
Room: Van Horne C
The goal of this plenary session is to discuss how metabolic pathways link inflammation and innate immune cells.
Speaker 6 of 7
David K. Finlay, Trinity Biomedical Sciences Institute, Ireland
Short Talk: SREBP Sustains Elevated Glycolysis and Effector Functions in Cytokine Activated Natural Killer Cells

Wednesday, February 24 | 8:00AM - 11:15AM
Metabolism of Inflammation and Innate Immune Responses
Room: Van Horne C
The goal of this plenary session is to discuss how metabolic pathways link inflammation and innate immune cells.
Speaker 7 of 7
Claudio Mauro, Queen Mary University of London, UK

Wednesday, February 24 | 8:00AM - 11:15AM
Signaling and Metabolic Enzymes
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 1 of 7
* Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada


Wednesday, February 24 | 8:00AM - 11:15AM
Signaling and Metabolic Enzymes
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 2 of 7
Nika N. Danial, Dana-Farber Cancer Institute, USA
Metabolic Heterogeneity in Molecular Subtypes of Diffuse Large B Cell Lymphoma


Wednesday, February 24 | 8:00AM - 11:15AM
Signaling and Metabolic Enzymes
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 3 of 7
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Nutrient Sensing and Tumor Metabolism


Wednesday, February 24 | 8:00AM - 11:15AM
Signaling and Metabolic Enzymes
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 4 of 7
Brendan D. Manning, Harvard School of Public Health, USA
Linking Growth Signaling to Anabolic Metabolism


Wednesday, February 24 | 8:00AM - 11:15AM
Signaling and Metabolic Enzymes
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 5 of 7
Kathryn E. Wellen, University of Pennsylvania, USA
Tumor Metabolism and the Epigenome


Wednesday, February 24 | 8:00AM - 11:15AM
Signaling and Metabolic Enzymes
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 6 of 7
Ahmad A. Cluntun, University of Utah, HHMI, USA
Short Talk: The Rate of Glycolysis Quantitatively Mediates Specific Histone Acetylation Sites


Wednesday, February 24 | 8:00AM - 11:15AM
Signaling and Metabolic Enzymes
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 7 of 7
Roberto Zoncu, University of California, Berkeley, USA
Short Talk: Convergence of Multiple Nutrient Signals Regulates mTORC1 at the Lysosome


Wednesday, February 24 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Wednesday, February 24 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Wednesday, February 24 | 11:15AM - 2:30PM
On Own for Lunch


Wednesday, February 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: The Metabolic Regulation of Innate Immunity
Room: Van Horne C

Speaker 1 of 10
* Janelle S. Ayres, The Salk Institute for Biological Studies, USA

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: The Metabolic Regulation of Innate Immunity
Room: Van Horne C

Speaker 2 of 10
* Steven J. Bensinger, University of California, Los Angeles, USA

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: The Metabolic Regulation of Innate Immunity
Room: Van Horne C

Speaker 3 of 10
Maroof Hasan, Novartis Institutes for BioMedical Research, Switzerland
Immuno-Metabolic Dysregulation in Aicardi-Goutieres Syndrome and Related Autoimmune Diseases

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: The Metabolic Regulation of Innate Immunity
Room: Van Horne C

Speaker 4 of 10
Jonathan M. Coquet, Karolinska Institutet, Sweden
The Role of PPAR-gamma in Type 2 Immunity

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: The Metabolic Regulation of Innate Immunity
Room: Van Horne C

Speaker 5 of 10
Emily L. Goldberg, Yale University, USA
Beta-Hydroxybutyrate, an Alternate Metabolic Fuel, Inhibits Neutrophilic Inflammation by Blocking NLRP3 Inflammasome Activation

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: The Metabolic Regulation of Innate Immunity
Room: Van Horne C

Speaker 6 of 10
Mahesh Raundhal, University of Pittsburgh, USA
PPARg Regulates Mitochondrial Respiration in CD11c+ Cells to Ensure Immune Tolerance in the Airways

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: The Metabolic Regulation of Innate Immunity
Room: Van Horne C

Speaker 7 of 10
Shuang Zhang, Harvard Medical School/Massachusetts General Hospital, USA
Apoptotic Cell Metabolites during Efferocytosis Fuel Mitochondrial-Directed Inflammatory Reprogramming in Macrophages

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: The Metabolic Regulation of Innate Immunity
Room: Van Horne C

Speaker 8 of 10
Samuel L. Collins, Johns Hopkins University, USA
mTORC2 Integrates Cues from the Environment to Program Macrophage Differentiation and Regulate Systemic Immune and Thermogenic Responses

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: The Metabolic Regulation of Innate Immunity
Room: Van Horne C

Speaker 9 of 10
Martin Pelletier, Centre de Recherche du CHU de Québec - Université Laval, Canada
Metabolic Adaptation of Polymorphonuclear Neutrophils Activated with Pro-Inflammatory Cytokines

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: The Metabolic Regulation of Innate Immunity
Room: Van Horne C

Speaker 10 of 10
José Carlos Farias Alves Filho, Universidade de São Paulo, Brazil
Fructose 1,6-bisphosphate, a High-Energy Intermediate of Glycolysis, Reprograms Macrophages Limiting their Activated State

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 1 of 9
* Kate Yen, Auron Therapeutics, USA


Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 2 of 9
Mark G. Manfredi, Raze Therapeutics, USA
One Carbon Metabolism in Cancer


Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 3 of 9
Maria Bueno, Centro Nacional de Investigaciones Oncológicas, Spain
FASN: A Metabolic Strategy for Breast Cancer Prevention


Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 4 of 9
Douglas I. Buckley, Sagimet Biosciences, USA
Sebum Analysis from Dose Escalation and Expansion Phases of the FASN Inhibitor TVB-2640 Phase 1 Trial, A Non-Invasive Biomarker of Target Engagement


Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 5 of 9
Sven Christian, Bayer, Germany
3D High-Content Screening for the Identification of Compounds that Target Cells in the Core of Tumor Spheroids


Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 6 of 9
Thomas Ashton, Gray Institute for Radiation Oncology and Biology, UK
Increasing Radiosensitivity by Alleviating Tumour Hypoxia: A Drug Screen Reveals Atovaquone as a Clinical Candidate


Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 7 of 9
Kathy Ann Gelato, Bayer Healthcare AG, Germany
OXPHOS and Epigenetics: Paths to BET Inhibitor Sensitivity in Melanoma


Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 8 of 9
Pankaj Kumar Singh, University of Nebraska Medical Center, USA
Metabolic Flux into Nucleotide Biosynthesis Pathway Regulates Chemotherapy Responsiveness in Pancreatic Cancer


Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
This session is from Tumor Metabolism
Room: Van Horne A/B

Speaker 9 of 9
Jing Chen, Winship Cancer Institute, Emory University, USA
Inhibition of Human Copper Trafficking by Small Molecule Significantly Attenuates Cancer Cell Proliferation


Wednesday, February 24 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, February 24 | 5:00PM - 7:00PM
Cell-Cell Communication in Immunometabolism
Room: Van Horne C
The goal of this session is to discuss how systemic changes in metabolism influence metabolism and interactions of immune cells with metabolic tissues.
Speaker 1 of 5
* Amira Klip, Hospital for Sick Children, Canada

Wednesday, February 24 | 5:00PM - 7:00PM
Cell-Cell Communication in Immunometabolism
Room: Van Horne C
The goal of this session is to discuss how systemic changes in metabolism influence metabolism and interactions of immune cells with metabolic tissues.
Speaker 2 of 5
Bente Klarlund Pedersen, University of Copenhagen, Denmark
Exercise-Induced Immunometabolism - Focus on Myokines

Wednesday, February 24 | 5:00PM - 7:00PM
Cell-Cell Communication in Immunometabolism
Room: Van Horne C
The goal of this session is to discuss how systemic changes in metabolism influence metabolism and interactions of immune cells with metabolic tissues.
Speaker 3 of 5
Benedicte Chazaud, Université Claude Bernard Lyon, France
Macrophages Differentially Regulate Myogenesis and Fibrogenesis in Acute Muscle Regeneration and Chronic Muscle Disease

Wednesday, February 24 | 5:00PM - 7:00PM
Cell-Cell Communication in Immunometabolism
Room: Van Horne C
The goal of this session is to discuss how systemic changes in metabolism influence metabolism and interactions of immune cells with metabolic tissues.
Speaker 4 of 5
Vishwa Deep Dixit, Yale University, USA
Immunometabolic Inhibitors of Inflammasome and Metchnikoff’s Prediction of Longevity

Wednesday, February 24 | 5:00PM - 7:00PM
Cell-Cell Communication in Immunometabolism
Room: Van Horne C
The goal of this session is to discuss how systemic changes in metabolism influence metabolism and interactions of immune cells with metabolic tissues.
Speaker 5 of 5
Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Short Talk: Muscle Wasting Protection Mediated by Microbiome E. coli Involves Inflammasome and IGF-1 Signaling

Wednesday, February 24 | 5:00PM - 7:15PM
PI3K/AMPK
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 1 of 6
* Lewis C. Cantley, Weill Cornell Medicine, USA


Wednesday, February 24 | 5:00PM - 7:15PM
PI3K/AMPK
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 2 of 6
Navdeep S. Chandel, Northwestern University, USA
Mitochondrial Function in Normal and Tumor Metabolism


Wednesday, February 24 | 5:00PM - 7:15PM
PI3K/AMPK
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 3 of 6
Nissim Hay, University of Illinois at Chicago, USA
Akt, Metabolism and Cancer Therapy: Surprising Lessons from Akt KO Mice


Wednesday, February 24 | 5:00PM - 7:15PM
PI3K/AMPK
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 4 of 6
Heather Christofk, University of California, Los Angeles, USA
Use of Viruses to Study Cancer Metabolism


Wednesday, February 24 | 5:00PM - 7:15PM
PI3K/AMPK
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 5 of 6
Boyi Gan, MD Anderson Cancer Center, USA
Short Talk: Regulation of AMPK Activation and Cancer Metabolism by Long Noncoding RNAs


Wednesday, February 24 | 5:00PM - 7:15PM
PI3K/AMPK
This session is from Tumor Metabolism
Room: Van Horne A/B
Post-Transcriptional Regulation of Metabolism
Speaker 6 of 6
Zachary Schug, Wistar Institute, USA
Short Talk: MYC Expression in Human Mammary Epithelial Cells Enhances Metabolic Plasticity


Wednesday, February 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Wednesday, February 24 | 7:30PM - 10:00PM
Poster Session 3
Room: Mezzanine 2


Thursday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Thursday, February 25 | 8:00AM - 11:15AM
Metabolic Reprogramming in Lymphocyte Cell Activation and Me
mory

Room: Van Horne C
The goal of this session is to discuss mechanisms that regulate metabolic changes in T cell activation and in generation of T cell memory.
Speaker 1 of 7
* Jonathan D. Powell, Johns Hopkins University School of Medicine, USA

Thursday, February 25 | 8:00AM - 11:15AM
Metabolic Reprogramming in Lymphocyte Cell Activation and Me
mory

Room: Van Horne C
The goal of this session is to discuss mechanisms that regulate metabolic changes in T cell activation and in generation of T cell memory.
Speaker 2 of 7
Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolism of Dendritic Cell Activation

Thursday, February 25 | 8:00AM - 11:15AM
Metabolic Reprogramming in Lymphocyte Cell Activation and Me
mory

Room: Van Horne C
The goal of this session is to discuss mechanisms that regulate metabolic changes in T cell activation and in generation of T cell memory.
Speaker 3 of 7
Christoph Hess, University Hospital Basel/University of Cambridge, Switzerland
Metabolic Reprogramming in Memory T Cells and Immunodeficiency

Thursday, February 25 | 8:00AM - 11:15AM
Metabolic Reprogramming in Lymphocyte Cell Activation and Me
mory

Room: Van Horne C
The goal of this session is to discuss mechanisms that regulate metabolic changes in T cell activation and in generation of T cell memory.
Speaker 4 of 7
Gary Glick, University of Michigan and IFM Therapeutics, USA
Mitochondrial Function in Immunity; Mechanisms and Therapeutic Potential

Thursday, February 25 | 8:00AM - 11:15AM
Metabolic Reprogramming in Lymphocyte Cell Activation and Me
mory

Room: Van Horne C
The goal of this session is to discuss mechanisms that regulate metabolic changes in T cell activation and in generation of T cell memory.
Speaker 5 of 7
Douglas R. Green, St. Jude Children's Research Hospital, USA
Born Different: Metabolic Maintenance of Asymmetric T Cell Division

Thursday, February 25 | 8:00AM - 11:15AM
Metabolic Reprogramming in Lymphocyte Cell Activation and Me
mory

Room: Van Horne C
The goal of this session is to discuss mechanisms that regulate metabolic changes in T cell activation and in generation of T cell memory.
Speaker 6 of 7
Greg M. Delgoffe, University of Pittsburgh, USA
Short Talk: Metabolic Insufficiency Underlies Intratumoral Cytotoxic T Cell Dysfunction

Thursday, February 25 | 8:00AM - 11:15AM
Metabolic Reprogramming in Lymphocyte Cell Activation and Me
mory

Room: Van Horne C
The goal of this session is to discuss mechanisms that regulate metabolic changes in T cell activation and in generation of T cell memory.
Speaker 7 of 7
Laurence Morel, University of Florida, USA
Short Talk: Targeting CD4+ T Cell Metabolism in Lupus

Thursday, February 25 | 8:00AM - 11:00AM
Isocitrate Dehydrogenase
This session is from Tumor Metabolism
Room: Van Horne A/B
Therapeutic Implications
Speaker 1 of 7
* Karen H. Vousden, Francis Crick Institute, UK


Thursday, February 25 | 8:00AM - 11:00AM
Isocitrate Dehydrogenase
This session is from Tumor Metabolism
Room: Van Horne A/B
Therapeutic Implications
Speaker 2 of 7
Kate Yen, Auron Therapeutics, USA
New Developments in Targeting IDH Mutations


Thursday, February 25 | 8:00AM - 11:00AM
Isocitrate Dehydrogenase
This session is from Tumor Metabolism
Room: Van Horne A/B
Therapeutic Implications
Speaker 3 of 7
Sunil Sudarshan, University of Alabama, Birmingham, USA
Short Talk: The L-2HG/L2HGDH Axis in Kidney Cancer


Thursday, February 25 | 8:00AM - 11:00AM
Isocitrate Dehydrogenase
This session is from Tumor Metabolism
Room: Van Horne A/B
Therapeutic Implications
Speaker 4 of 7
Wilhelm Palm, Memorial Sloan-Kettering Cancer Center, USA
Beyond Glucose and Glutamine: Some Cancer Cells Utilize Extracellular Macromolecules to Fuel Cell Growth


Thursday, February 25 | 8:00AM - 11:00AM
Isocitrate Dehydrogenase
This session is from Tumor Metabolism
Room: Van Horne A/B
Therapeutic Implications
Speaker 5 of 7
Nabeel Bardeesy, Massachusetts General Hospital, USA
Altered Metabolism in Pancreatic Cancer Models


Thursday, February 25 | 8:00AM - 11:00AM
Isocitrate Dehydrogenase
This session is from Tumor Metabolism
Room: Van Horne A/B
Therapeutic Implications
Speaker 6 of 7
Alexander H. Stegh, Northwestern University, USA
Short Talk: IDH1 Promotes Tumor Growth and Resistance to Targeted Therapies in the Absence of Mutation


Thursday, February 25 | 8:00AM - 11:00AM
Isocitrate Dehydrogenase
This session is from Tumor Metabolism
Room: Van Horne A/B
Therapeutic Implications
Speaker 7 of 7
Kate Hollinshead, New York University Langone Health, USA
Short Talk: IDH1 Mutated Cells Demonstrate Pseudohypoxic Proline Metabolism


Thursday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Thursday, February 25 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, February 25 | 5:00PM - 7:00PM
Tumor Immunology and Metabolic Immunotherapy
Room: Van Horne C
The goal of this session is to discuss the role of the tumor microenvironment in control of anti-tumor immunity.
Speaker 1 of 5
* Laurence A. Turka, Rheos Medicines, USA

Thursday, February 25 | 5:00PM - 7:00PM
Tumor Immunology and Metabolic Immunotherapy
Room: Van Horne C
The goal of this session is to discuss the role of the tumor microenvironment in control of anti-tumor immunity.
Speaker 2 of 5
David H. Munn, Georgia Regents University, USA
IDO, PTEN and mTOR / Akt Signaling in Tregs

Thursday, February 25 | 5:00PM - 7:00PM
Tumor Immunology and Metabolic Immunotherapy
Room: Van Horne C
The goal of this session is to discuss the role of the tumor microenvironment in control of anti-tumor immunity.
Speaker 3 of 5
Madhusudhanan Sukumar, NCI, National Institutes of Health, USA
Metabolic Properties of Highly Effective T Cells

Thursday, February 25 | 5:00PM - 7:00PM
Tumor Immunology and Metabolic Immunotherapy
Room: Van Horne C
The goal of this session is to discuss the role of the tumor microenvironment in control of anti-tumor immunity.
Speaker 4 of 5
Susan M. Kaech, The Salk Institute, USA
Fattening Up T Cell Memory

Thursday, February 25 | 5:00PM - 7:00PM
Tumor Immunology and Metabolic Immunotherapy
Room: Van Horne C
The goal of this session is to discuss the role of the tumor microenvironment in control of anti-tumor immunity.
Speaker 5 of 5
Bertram Bengsch, University of Pennsylvania, USA
Short Talk: Early Onset and Persistence of Metabolic Alterations in Exhausted T-Cells is Controlled by PD-1

Thursday, February 25 | 5:00PM - 7:15PM
Targeting Metabolism
This session is from Tumor Metabolism
Room: Van Horne A/B
Therapeutic Implications
Speaker 1 of 5
* Robert N. Eisenman, Fred Hutchinson Cancer Research Center, USA


Thursday, February 25 | 5:00PM - 7:15PM
Targeting Metabolism
This session is from Tumor Metabolism
Room: Van Horne A/B
Therapeutic Implications
Speaker 2 of 5
Chi Van Dang, University of Pennsylvania, USA
A Time for MYC, Metabolism, and Therapy


Thursday, February 25 | 5:00PM - 7:15PM
Targeting Metabolism
This session is from Tumor Metabolism
Room: Van Horne A/B
Therapeutic Implications
Speaker 3 of 5
Susan Demo, Calithera Biosciences, USA
Targeting Amino Acid Metabolism for Cancer Treatment


Thursday, February 25 | 5:00PM - 7:15PM
Targeting Metabolism
This session is from Tumor Metabolism
Room: Van Horne A/B
Therapeutic Implications
Speaker 4 of 5
Michael Pollak, Jewish General Hospital, Canada
Targeting Cancer Metabolism with Metformin and Other Biguanides: From Bench to Bedside and Back


Thursday, February 25 | 5:00PM - 7:15PM
Targeting Metabolism
This session is from Tumor Metabolism
Room: Van Horne A/B
Therapeutic Implications
Speaker 5 of 5
Alec Kimmelman, New York University Langone Medical Center, USA
Identifying Metabolic Dependencies in Pancreatic Cancer


Thursday, February 25 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Van Horne C


Thursday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2
No registration fees are used to fund alcohol served at this function.

Thursday, February 25 | 7:15PM - 7:30PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Tumor Metabolism
Room: Van Horne A/B


Thursday, February 25 | 8:00PM - 11:00PM
Entertainment
Room: Mezzanine 2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 25 | 8:00PM - 11:00PM
Cash Bar
Room: Mezzanine 2


Friday, February 26 | 10:25AM - 10:25AM
Departure


*Session Chair.