Web Desc
Antibodies as Drugs
joint with Cancer Vaccines: Targeting Cancer Genes for Immunotherapy
Organizer(s): Peter D. Senter, Anna M. Wu, Alan J. Korman and Karl Dane Wittrup
Date: March 06 - 10, 2016
Location: Fairmont Chateau Whistler, Whistler, BC, Canada
Sponsored by Genentech, Inc., Genmab A/S, ImmunoGen, Inc., Mersana Therapeutics, MorphoSys AG, OncoMed Pharmaceuticals, Inc. and Regeneron Pharmaceuticals, Inc.
Summary of Meeting:
Monoclonal antibodies have had a pronounced impact in medicine and biology, with a broad array of approved agents that are used for the diagnosis, treatment and characterization of cancers, immunological disorders, and infectious diseases. Because of their exquisite target specificities, together with their favorable pharmacologic properties, antibodies are destined to have even increased clinical impact, particularly in diseases that are understood at the molecular level. This Keystone Symposia meeting will focus attention on many of the key advances in antibody-based technologies as well as on where the field is heading. Some of the critical topics to be covered include: 1) Antibody structure and function; 2) Engineered antibodies and antibody-like molecules for improved efficacy; 3) Antibody pharmacologic properties and biologic distribution; 4) Antibody-based therapies for cancer and infectious diseases; 5) Targeting costimulatory pathways and immunological checkpoints; 6) Antibodies as carriers of drugs, cytokines, radioisotopes and imaging agents; 7) Antibody mimetics; 8) Clinical advancements and challenges. This meeting has become an established forum that attracts both new investigators and leaders in the field, coming from academia, industry and research institutes around the globe. The goals of the meeting will be to address the critical issues facing the broad field of antibody-based therapeutics, provide an overview of recent advances and bring together interdisciplinary groups for the generation of new ideas and promising areas of investigation.
Scholarship Deadline: November 5 2015
Discounted Abstract Deadline: November 5 2015
Abstract Deadline: December 8 2015
Discounted Registration Deadline: January 7 2016
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Genentech, Inc.Genmab A/SImmunoGen, Inc.Mersana TherapeuticsMorphoSys AGOncoMed Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.
We gratefully acknowledge additional support for this conference from:
Molecular PharmaceuticsOpsona Therapeutics Ltd
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Adimab, Inc.

Bristol-Myers Squibb Company

EMBO Young Investigator Programme

Genentech, Inc.

Genmab A/S

Juno Therapeutics
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI122357-01
Funding for this conference was made possible (in part) by 1 R13 AI 122357 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 06 | 4:00PM - 8:00PM
Arrival and Registration
Room: Macdonald Foyer


Sunday, March 06 | 6:00PM - 8:00PM
Welcome Mixer
Room: Macdonald Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac


Monday, March 07 | 7:30AM - 8:00AM
Poster Setup
Room: Frontenac


Monday, March 07 | 8:00AM - 5:00PM
Poster Viewing
Room: Frontenac


Monday, March 07 | 8:00AM - 10:00AM
Welcome and Keynote Session
Room: Macdonald ABC

Speaker 1 of 3
* Peter D. Senter, Seattle Genetics Inc., USA

Monday, March 07 | 8:00AM - 10:00AM
Welcome and Keynote Session
Room: Macdonald ABC

Speaker 2 of 3
Rakesh K. Jain, Massachusetts General Hospital and Harvard Medical School, USA
Reengineering the Tumor Microenvironment to Enhance Cancer Treatment: Bench to Bedside

Monday, March 07 | 8:00AM - 10:00AM
Welcome and Keynote Session
Room: Macdonald ABC

Speaker 3 of 3
Andreas G. Plückthun, University of Zürich, Switzerland
Protein Engineering Approaches to New Biologicals

Monday, March 07 | 10:00AM - 10:20AM
Coffee Break
Room: Macdonald Foyer


Monday, March 07 | 10:20AM - 11:45AM
Getting Antibodies to Where They Need to Go
Room: Macdonald ABC
The session will cover some of the major underlying challenges facing the field of antibody based therapeutics.
Speaker 1 of 4
* Peter D. Senter, Seattle Genetics Inc., USA

Monday, March 07 | 10:20AM - 11:45AM
Getting Antibodies to Where They Need to Go
Room: Macdonald ABC
The session will cover some of the major underlying challenges facing the field of antibody based therapeutics.
Speaker 2 of 4
James M. Olson, Fred Hutchinson Cancer Research Center, USA
Micro Needle Technologies for Intratumoral Drug Delivery and Combination Screening

Monday, March 07 | 10:20AM - 11:45AM
Getting Antibodies to Where They Need to Go
Room: Macdonald ABC
The session will cover some of the major underlying challenges facing the field of antibody based therapeutics.
Speaker 3 of 4
Alison M. Betts, Pfizer, Inc., USA
PK/PD Modeling for Macromolecular Drug Delivery

Monday, March 07 | 10:20AM - 11:45AM
Getting Antibodies to Where They Need to Go
Room: Macdonald ABC
The session will cover some of the major underlying challenges facing the field of antibody based therapeutics.
Speaker 4 of 4
Richard Tavaré, University of California, Los Angeles, USA
Short Talk: Noninvasive Detection of Tumor-Infiltrating Lymphocytes using Anti-CD8 Immuno-PET: Impact of Protein Dose

Monday, March 07 | 10:20AM - 11:30AM
Antigens
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 1 of 3
* A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA


Monday, March 07 | 10:20AM - 11:30AM
Antigens
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 2 of 3
Cornelis J. M. Melief, Leiden University Medical Center & ISA Pharmaceuticals BV, Netherlands
Synergy of Therapeutic Vaccination against HPV16 Oncogenic Proteins and Standard Chemotherapeutics


Monday, March 07 | 10:20AM - 11:30AM
Antigens
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 3 of 3
Victor H. Engelhard, University of Virginia, USA
Phosphopeptides Displayed by MHC Molecules as New-Generation Cancer Vaccine Targets


Monday, March 07 | 11:45AM - 12:30PM
Lunch
Room: Frontenac


Monday, March 07 | 12:00PM - 2:30PM
Poster Session 1
Room: Frontenac


Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Novel Constructs
Room: Macdonald ABC

Speaker 1 of 7
* Dennis R. Benjamin, Seattle Genetics Inc., USA

Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Novel Constructs
Room: Macdonald ABC

Speaker 2 of 7
Jonathan H. Davis, Invenra, USA
Synergy Generates Picomolar Potency and a High Resistance Barrier in Combinectin, a Novel Trispecific HIV-1 Entry Inhibitor with Clinical Promise

Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Novel Constructs
Room: Macdonald ABC

Speaker 3 of 7
Eric Hatterer, NovImmune.SA, Switzerland
Characterizing the Preclinical Candidate, NI-1701, a CD47 Targeting Bispecific Antibody in Development for the Treatment of B Cell Lymphomas and Leukemias

Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Novel Constructs
Room: Macdonald ABC

Speaker 4 of 7
Paul A. Moore, MacroGenics, USA
MGD009, a B7-H3 x CD3 Bispecific Dual-Affinity Re-Targeting (DART®) Molecule Directing T Cells to Solid Tumors

Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Novel Constructs
Room: Macdonald ABC

Speaker 5 of 7
Marijn A. Gillissen, Aimm Therapeutics / AMC, Netherlands
Donor-Derived B Cells Produce Potent AML-Specific Antibodies that Recognize a Novel Tumor-Specific Antigen and Mediate Graft-Versus- Leukemia Immunity

Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Novel Constructs
Room: Macdonald ABC

Speaker 6 of 7
Yu-Sang Sabrina Yang, Massachusetts Institute of Technology, USA
Targeting Immunomodulators to Lymphocytes Via Amphiphilic Gold Nanocarriers

Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Novel Constructs
Room: Macdonald ABC

Speaker 7 of 7
Travis Young, California Institute for Biomedical Research, USA
Antibody-based Control of CAR-T Cell Therapy

Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Molecular Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 1 of 9
* Darrell J. Irvine, Massachusetts Institute of Technology, USA


Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Molecular Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 2 of 9
* Yvette van Kooyk, Vrije University Medical Center, Netherlands


Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Molecular Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 3 of 9
Tomasz Ahrends, Netherlands Cancer Institute, Netherlands
Combined CD27-Costimulation and PD-1-Inhibition Recapitulates CD4+ T-cell Help in Therapeutic Vaccination Against Cancer


Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Molecular Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 4 of 9
Suresh de Silva, Heat Biologics Inc., USA
Combination Immunotherapy: T-cell Costimulation (OX40L, TL1A, 4-1BBL and ICOSL) Secreted Locally by Gp96-Ig Vaccines, Elicits Robust Antigen-Specific, Memory T Cell Responses and Tumor Elimination


Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Molecular Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 5 of 9
Christa I. DeVette, University of Oklahoma Health Sciences Center, USA
Development of Tools to Evaluate Anti-tumor Immunity


Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Molecular Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 6 of 9
James Moon, University of Michigan, USA
Nanodisc-Based Peptide Vaccines for Personalized Cancer Immunotherapy


Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Molecular Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 7 of 9
Geoffrey Lynn, Avidea Technologies, USA
Self-Assembling Nanoparticles Codelivering Peptide Neoantigens and TLR-7/8 Agonists Enhance the Breadth and Potency of Anti-Tumor Immunity


Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Molecular Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 8 of 9
Naveen Mehta, Massachusetts Institute of Technology, USA
Utilizing Protein Carriers to Engineer Cancer Vaccines with Improved Potency


Monday, March 07 | 2:30PM - 4:30PM
Workshop 1: Molecular Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 9 of 9
Kristen Radford, University of Queensland, Australia
Targeting Antigen to Human CD141+ Dendritic Cells via CLEC9A in vitro and in vivo Confers Effective Cross-Presentation to CD8+ T Cells


Monday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Monday, March 07 | 5:00PM - 7:15PM
Engineering Antibody Function
Room: Macdonald ABC

Speaker 1 of 5
* Alison M. Betts, Pfizer, Inc., USA

Monday, March 07 | 5:00PM - 7:15PM
Engineering Antibody Function
Room: Macdonald ABC

Speaker 2 of 5
Margaret E. Ackerman, Dartmouth College, USA
Evolution of Antibodies for Optimized Effector Function Activities

Monday, March 07 | 5:00PM - 7:15PM
Engineering Antibody Function
Room: Macdonald ABC

Speaker 3 of 5
Jeanette H.W. Leusen, University Medical Center Utrecht, Netherlands
IgA as Alternative Therapeutic Antibody: Combination with IgG, Half-Life Extension and More

Monday, March 07 | 5:00PM - 7:15PM
Engineering Antibody Function
Room: Macdonald ABC

Speaker 4 of 5
Sarel J. Fleishman, Weizmann Institute of Science, Israel
De novo Design of Novel Protein Functions

Monday, March 07 | 5:00PM - 7:15PM
Engineering Antibody Function
Room: Macdonald ABC

Speaker 5 of 5
Paul W. H. I. Parren, Leiden University Medical Center, Netherlands
Functional Aspects of Antigen- and Fc-Dependent IgG Hexamer Formation

Monday, March 07 | 5:00PM - 7:00PM
Antigen-Presenting Cells
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 1 of 5
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA


Monday, March 07 | 5:00PM - 7:00PM
Antigen-Presenting Cells
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 2 of 5
Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Regulation of Antigen Cross-presentation in Dendritic Cells


Monday, March 07 | 5:00PM - 7:00PM
Antigen-Presenting Cells
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 3 of 5
A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA
Dendritic Cells as Cancer Vaccines


Monday, March 07 | 5:00PM - 7:00PM
Antigen-Presenting Cells
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 4 of 5
Matthew F. Krummel, University of California, San Francisco, USA
T Cell-Antigen Presenting Dynamics in the Tumor Microenvironment


Monday, March 07 | 5:00PM - 7:00PM
Antigen-Presenting Cells
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 5 of 5
Brian J. Francica, Tempest Therapeutics, USA
Short Talk: Radio-resistant Stromal Cells Initiate the Innate Response to Cyclic Dinucleotides


Monday, March 07 | 7:15PM - 7:15PM
On Own for Dinner


Tuesday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac


Tuesday, March 08 | 8:00AM - 11:00AM
B Cell Biology and Antibody Repertoires
Room: Macdonald ABC
How the immune system adapts to infection and other challenges, and how antibody combinations can be used to treat diseases.
Speaker 1 of 6
* David A. Scheinberg, Memorial Sloan Kettering Cancer Center, USA

Tuesday, March 08 | 8:00AM - 11:00AM
B Cell Biology and Antibody Repertoires
Room: Macdonald ABC
How the immune system adapts to infection and other challenges, and how antibody combinations can be used to treat diseases.
Speaker 2 of 6
George Georgiou, University of Texas at Austin, USA
Systematic Characterization and Comparative Analysis of Antibody Repertoires

Tuesday, March 08 | 8:00AM - 11:00AM
B Cell Biology and Antibody Repertoires
Room: Macdonald ABC
How the immune system adapts to infection and other challenges, and how antibody combinations can be used to treat diseases.
Speaker 3 of 6
Pavel Tolar, Francis Crick Institute, UK
EMBO Young Investigator Lecture: Regulation of Antibody Responses by B Cell Mechanical Activity

Tuesday, March 08 | 8:00AM - 11:00AM
B Cell Biology and Antibody Repertoires
Room: Macdonald ABC
How the immune system adapts to infection and other challenges, and how antibody combinations can be used to treat diseases.
Speaker 4 of 6
Laura M. Walker, Adimab LLC, USA
Rapid and Large-Scale Isolation of Potent Neutralizing Antibodies from a Survivor of the 2014 Ebola Virus Outbreak

Tuesday, March 08 | 8:00AM - 11:00AM
B Cell Biology and Antibody Repertoires
Room: Macdonald ABC
How the immune system adapts to infection and other challenges, and how antibody combinations can be used to treat diseases.
Speaker 5 of 6
Paul A. Ramsland, RMIT University, Australia
Short Talk: Unanticipated Global Changes in IgG1 from Mutation of FcRn Binding Site Residues

Tuesday, March 08 | 8:00AM - 11:00AM
B Cell Biology and Antibody Repertoires
Room: Macdonald ABC
How the immune system adapts to infection and other challenges, and how antibody combinations can be used to treat diseases.
Speaker 6 of 6
Sai T. Reddy, ETH Zurich, Switzerland
Short Talk: Correlations of Antibody Response Phenotype to Genotype Revealed by Molecular Amplification Fingerprinting

Tuesday, March 08 | 8:00AM - 11:15AM
Priming Effector T Cells
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 1 of 7
* Sebastian Amigorena, Institut Curie, France


Tuesday, March 08 | 8:00AM - 11:15AM
Priming Effector T Cells
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 2 of 7
Victor Appay, INSERM U1135 - CIMI, France
Impaired Induction of High-Quality Effector CD8+ T-Cells in Old Humans


Tuesday, March 08 | 8:00AM - 11:15AM
Priming Effector T Cells
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 3 of 7
Luca Gattinoni, NCI, National Institutes of Health, USA
Generation of Long-Lived Cancer Antigen-Specific CD8+ T Cell Memory


Tuesday, March 08 | 8:00AM - 11:15AM
Priming Effector T Cells
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 4 of 7
Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
Novel Subsets Involved in T Cell Anti-Tumor Immunity


Tuesday, March 08 | 8:00AM - 11:15AM
Priming Effector T Cells
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 5 of 7
Ugur Sahin, BioNTech AG, Germany
Exploiting Antiviral Immune Mechanisms for Cancer Immunotherapy


Tuesday, March 08 | 8:00AM - 11:15AM
Priming Effector T Cells
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 6 of 7
Dixon Dorand, Case Western Reserve University, USA
Short Talk: Cyclin Dependent Kinase 5 (CDK5) Controls PD-L1 Expression via Phosphorylation of IRF2BP2 in Murine Medulloblastoma and CDK5 Deficiency Results in CD4+ Dependent T-Cell Rejection


Tuesday, March 08 | 8:00AM - 11:15AM
Priming Effector T Cells
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 7 of 7
Alison Taylor, University of Cambridge, UK
Short Talk: Glycogen Synthase Kinase 3 Inhibition Blocks PD-1 Expression via Increased Tbet Expression for Enhanced CD8+ Cytolytic T-Cell Responses


Tuesday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Tuesday, March 08 | 11:00AM - 1:00PM
Poster Setup
Room: Frontenac


Tuesday, March 08 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Frontenac


Tuesday, March 08 | 2:30PM - 4:30PM
Workshop 2: Cell-Based Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 1 of 9
* Masaki Terabe, NCI, National Institutes of Health, USA


Tuesday, March 08 | 2:30PM - 4:30PM
Workshop 2: Cell-Based Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 2 of 9
* Robert A. Seder, NIAID, National Institutes of Health, USA


Tuesday, March 08 | 2:30PM - 4:30PM
Workshop 2: Cell-Based Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 3 of 9
Andres Alloatti, Institut Curie, France
Dissecting Cross-Presentation in Dendritic Cells: Who, How and Why?


Tuesday, March 08 | 2:30PM - 4:30PM
Workshop 2: Cell-Based Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 4 of 9
Anja C. Bloom, NCI, National Institutes of Health, USA
INT230-6 Administered Intratumorally Converts Tumor to an Endogenous Vaccine in Mouse Colon Cancer


Tuesday, March 08 | 2:30PM - 4:30PM
Workshop 2: Cell-Based Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 5 of 9
Agamemnon Antoniou Epenetos, Imperial College London, UK
Creation of Biological Microparticles from Mesenchymal Stem Cell (MSC) to Deliver Vaccines and other Therapeutics such as Proteins or Nucleic Acids


Tuesday, March 08 | 2:30PM - 4:30PM
Workshop 2: Cell-Based Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 6 of 9
Simon Heidegger, Klinikum Rechts der Isar, Technical University Munich, Germany
Activation of the Cytosolic RNA Receptor RIG-I in Tumor and Immune Cells Triggers Efficient Anti-Tumor Immunity and Synergizes with Checkpoint Blockade


Tuesday, March 08 | 2:30PM - 4:30PM
Workshop 2: Cell-Based Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 7 of 9
Kavya Rakhra, Massachusetts Institute of Technology, USA
Combination Immunotherapy of an Autochthonous Murine Lung Cancer Model Expressing Human CEA as a Tumor-Associated Self-Antigen


Tuesday, March 08 | 2:30PM - 4:30PM
Workshop 2: Cell-Based Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 8 of 9
Yvette van Kooyk, Vrije University Medical Center, Netherlands
Vaccines Facilitating Cross-Presentation for the Induction of Tumor-Immunity Overcoming Tumor Induced Suppression


Tuesday, March 08 | 2:30PM - 4:30PM
Workshop 2: Cell-Based Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 9 of 9
Megan C. Wise, Inovio Pharmaceuticals, USA
Various forms of CD40L Encoded as an Immune Plasmid Adjuvant Generate Unique Anti-HPV DNA Vaccine Induced Responses


Tuesday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Tuesday, March 08 | 5:00PM - 7:15PM
Novel Antibody Constructs
Room: Macdonald ABC

Speaker 1 of 5
* Anna M. Wu, University of California, Los Angeles, USA

Tuesday, March 08 | 5:00PM - 7:15PM
Novel Antibody Constructs
Room: Macdonald ABC

Speaker 2 of 5
David A. Scheinberg, Memorial Sloan Kettering Cancer Center, USA
Drugging Intracellular Targets with Vaccines and Human Therapeutic TCR Mimic Antibodies

Tuesday, March 08 | 5:00PM - 7:15PM
Novel Antibody Constructs
Room: Macdonald ABC

Speaker 3 of 5
Dennis R. Benjamin, Seattle Genetics Inc., USA
Antibody Drug Conjugates for Cancer Therapy

Tuesday, March 08 | 5:00PM - 7:15PM
Novel Antibody Constructs
Room: Macdonald ABC

Speaker 4 of 5
Birgit Schoeberl, Novartis Institutes for BioMedical Research, USA
Multispecific Antibody Therapeutics Derived from Systems Biology and Computational Modeling

Tuesday, March 08 | 5:00PM - 7:15PM
Novel Antibody Constructs
Room: Macdonald ABC

Speaker 5 of 5
John C. Williams, Beckman Research Institute at City of Hope, USA
Functionalization of MAbs Using Mechanical Bonds

Tuesday, March 08 | 5:00PM - 7:00PM
Reprogramming T Cell Memory
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 1 of 5
* Victor Appay, INSERM U1135 - CIMI, France


Tuesday, March 08 | 5:00PM - 7:00PM
Reprogramming T Cell Memory
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 2 of 5
Rafi Ahmed, Emory University School of Medicine, USA
Features of Memory CD8+ T Cells in Chronic Infection


Tuesday, March 08 | 5:00PM - 7:00PM
Reprogramming T Cell Memory
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 3 of 5
Nicholas P. Restifo, Lyell, USA
Lineage Relationship of Effector and Memory T Cells


Tuesday, March 08 | 5:00PM - 7:00PM
Reprogramming T Cell Memory
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 4 of 5
Jonathan D. Powell, Johns Hopkins University School of Medicine, USA
Targeting Immunometabolism as a Means of Enhancing Immunotherapy


Tuesday, March 08 | 5:00PM - 7:00PM
Reprogramming T Cell Memory
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 5 of 5
Madhusudhanan Sukumar, NCI, National Institutes of Health, USA
Short Talk: Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for TCR and CAR based Adoptive Immunotherapy of Cancer


Tuesday, March 08 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Frontenac
No registration fees are used to fund alcohol served at this function.

Tuesday, March 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Frontenac


Wednesday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac


Wednesday, March 09 | 8:00AM - 11:00AM
Targeted Delivery for Imaging and Therapy
Room: Macdonald ABC

Speaker 1 of 6
* Alan J. Korman, Vir Biotechnology, Inc., USA

Wednesday, March 09 | 8:00AM - 11:00AM
Targeted Delivery for Imaging and Therapy
Room: Macdonald ABC

Speaker 2 of 6
Anna M. Wu, University of California, Los Angeles, USA
Detecting Tumor and Immune Cell Responses to Therapy Using ImmunoPET

Wednesday, March 09 | 8:00AM - 11:00AM
Targeted Delivery for Imaging and Therapy
Room: Macdonald ABC

Speaker 3 of 6
Katherine A. Vallis, University of Oxford, UK
Antibody-Based Radiotherapy and Radiodetection of Cancer

Wednesday, March 09 | 8:00AM - 11:00AM
Targeted Delivery for Imaging and Therapy
Room: Macdonald ABC

Speaker 4 of 6
Colin E. Correnti, Fred Hutchinson Cancer Research Center, USA
Tumor Paint and Penetrating Peptide Drug Conjugates

Wednesday, March 09 | 8:00AM - 11:00AM
Targeted Delivery for Imaging and Therapy
Room: Macdonald ABC

Speaker 5 of 6
Jacob Petersburg, University of Minnesota, USA
Short Talk: Utilizing Prosthetic Antigen Receptors (PARs) for Anti-EpCAM Cell-directed Immunotherapy

Wednesday, March 09 | 8:00AM - 11:00AM
Targeted Delivery for Imaging and Therapy
Room: Macdonald ABC

Speaker 6 of 6
David T. Rodgers, Calibr, USA
Short Talk: Antibody Based Switches Control the Activation and Targeting of CAR T Cells for B Cell Malignancies

Wednesday, March 09 | 8:00AM - 11:00AM
Cancer Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 1 of 6
* Cornelis J. M. Melief, Leiden University Medical Center & ISA Pharmaceuticals BV, Netherlands


Wednesday, March 09 | 8:00AM - 11:00AM
Cancer Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 2 of 6
Laurence Zitvogel, Institut Gustave Roussy, France
Molecular Mechanisms of Cancer Antigen Presentation at the Tumor Site


Wednesday, March 09 | 8:00AM - 11:00AM
Cancer Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 3 of 6
Thomas W. Dubensky, Jr., Tempest Therapeutics, USA
Insights from Listeria monocytogenes for the Development of Vector- and Small Molecule-Based Cancer Immunotherapy Strategies


Wednesday, March 09 | 8:00AM - 11:00AM
Cancer Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 4 of 6
Howard L. Kaufman, Massachusetts General Hospital, USA
Advances in Oncolytic Virus Immunotherapy


Wednesday, March 09 | 8:00AM - 11:00AM
Cancer Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 5 of 6
Sandra Demaria, Weill Cornell Medical College, USA
In situ Vaccination by Radiation Therapy


Wednesday, March 09 | 8:00AM - 11:00AM
Cancer Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 6 of 6
Rupert Kenefeck, Immunocore Ltd., UK
Short Talk: Overcoming Immune Regulation to Kill Cancers: ImmTAC Targeting and Checkpoint Inhibition


Wednesday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Wednesday, March 09 | 11:00AM - 1:00PM
Poster Setup
Room: Frontenac


Wednesday, March 09 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, March 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Frontenac


Wednesday, March 09 | 2:30PM - 4:30PM
Workshop 2: Novel Designs and Therapeutics
Room: Macdonald Ballroom

Speaker 1 of 8
* Margaret E. Ackerman, Dartmouth College, USA

Wednesday, March 09 | 2:30PM - 4:30PM
Workshop 2: Novel Designs and Therapeutics
Room: Macdonald Ballroom

Speaker 2 of 8
Hamid Bassiri, Children's Hospital of Philadelphia, USA
Novel Invariant Natural Killer T Cell-Based Immunotherapies for Cancer

Wednesday, March 09 | 2:30PM - 4:30PM
Workshop 2: Novel Designs and Therapeutics
Room: Macdonald Ballroom

Speaker 3 of 8
Hanke Matlung, Sanquin Research and Landsteiner Laboratory, Netherlands
Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

Wednesday, March 09 | 2:30PM - 4:30PM
Workshop 2: Novel Designs and Therapeutics
Room: Macdonald Ballroom

Speaker 4 of 8
Sheena N. Smith, University of Zurich, Switzerland
Targeted Adenoviral Delivery of Protein-Based Therapeutics to the Tumor Microenvironment

Wednesday, March 09 | 2:30PM - 4:30PM
Workshop 2: Novel Designs and Therapeutics
Room: Macdonald Ballroom

Speaker 5 of 8
Michael W. Munks, Oregon Health & Science University, USA
Major Histocompatibility Class I - Antibody Fusion Proteins (pMHCI-IgGs) that Link B16 Melanoma Cells to Cytomegalovirus-Specific CD8 T Cells Control B16 Melanoma in vivo

Wednesday, March 09 | 2:30PM - 4:30PM
Workshop 2: Novel Designs and Therapeutics
Room: Macdonald Ballroom

Speaker 6 of 8
Huafeng Xu, D.E. Shaw Research LLC, USA
Divergent Sequences Stabilize Similar Antigen-Binding Conformations in the Affinity Maturation of a Broadly Neutralizing Influenza Antibody Lineage

Wednesday, March 09 | 2:30PM - 4:30PM
Workshop 2: Novel Designs and Therapeutics
Room: Macdonald Ballroom

Speaker 7 of 8
David P. Humphreys, UCB Pharma, UK
Statistical Design for Effector Function Engineering of Hexameric Fc Domains

Wednesday, March 09 | 2:30PM - 4:30PM
Workshop 2: Novel Designs and Therapeutics
Room: Macdonald Ballroom

Speaker 8 of 8
Andre BH Choo, Bioprocessing Technology Institute, Singapore
Glycan: A Sweet Opportunity for Antibody Discovery

Wednesday, March 09 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Wednesday, March 09 | 5:00PM - 7:00PM
Antibodies for Checkpoint Blockade (Joint)
Room: Macdonald Ballroom

Speaker 1 of 4
* Madhav V. Dhodapkar, Yale School of Medicine, USA

Wednesday, March 09 | 5:00PM - 7:00PM
Antibodies for Checkpoint Blockade (Joint)
Room: Macdonald Ballroom

Speaker 2 of 4
Alan J. Korman, Vir Biotechnology, Inc., USA
Antitumor Activity of Immunomodulatory Antibodies

Wednesday, March 09 | 5:00PM - 7:00PM
Antibodies for Checkpoint Blockade (Joint)
Room: Macdonald Ballroom

Speaker 3 of 4
Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA
PD-1 Blockade in Cancer Therapy: Mechanism-Based Biomarkers and New Frontiers

Wednesday, March 09 | 5:00PM - 7:00PM
Antibodies for Checkpoint Blockade (Joint)
Room: Macdonald Ballroom

Speaker 4 of 4
John J. Miles, QIMR Berghofer Medical Research Institute, Australia
CD96/TIGIT/DNAM Pathway and Tumor Rejection

Wednesday, March 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac
No registration fees are used to fund alcohol served at this function.

Wednesday, March 09 | 7:30PM - 10:00PM
Poster Session 3
Room: Frontenac


Thursday, March 10 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac


Thursday, March 10 | 8:00AM - 11:15AM
Antibodies as Co-Factors (Joint)
Room: Macdonald Ballroom

Speaker 1 of 7
* Laurence Zitvogel, Institut Gustave Roussy, France

Thursday, March 10 | 8:00AM - 11:15AM
Antibodies as Co-Factors (Joint)
Room: Macdonald Ballroom

Speaker 2 of 7
Madhav V. Dhodapkar, Yale School of Medicine, USA
Harnessing Host Response to Premalignancy in Prevention of Cancer

Thursday, March 10 | 8:00AM - 11:15AM
Antibodies as Co-Factors (Joint)
Room: Macdonald Ballroom

Speaker 3 of 7
Carl G. Figdor, Radboud University Medical Center, Netherlands
Dendritic Cell Based Cancer Immunotherapy

Thursday, March 10 | 8:00AM - 11:15AM
Antibodies as Co-Factors (Joint)
Room: Macdonald Ballroom

Speaker 4 of 7
Ira Mellman, Genentech, Inc., USA
The Mechanistic Basis of Cancer Immunotherapy

Thursday, March 10 | 8:00AM - 11:15AM
Antibodies as Co-Factors (Joint)
Room: Macdonald Ballroom

Speaker 5 of 7
Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA
Modulation of Innate Immunity in Cancer

Thursday, March 10 | 8:00AM - 11:15AM
Antibodies as Co-Factors (Joint)
Room: Macdonald Ballroom

Speaker 6 of 7
Kelly D. Moynihan, Third Rock Ventures, USA
Short Talk: Eradication of Large Established Tumors by Combination Immunotherapy Engaging Innate and Adaptive Immunity

Thursday, March 10 | 8:00AM - 11:15AM
Antibodies as Co-Factors (Joint)
Room: Macdonald Ballroom

Speaker 7 of 7
Rony Dahan, Rockefeller University, USA
Short Talk: Improved Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Abs by Selective FcgammaR-Engagement

Thursday, March 10 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Thursday, March 10 | 11:15AM - 2:30PM
On Own for Lunch


Thursday, March 10 | 2:30PM - 4:30PM
Workshop 3: Peptides as Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 1 of 9
* Robert D. Schreiber, Washington University School of Medicine, USA


Thursday, March 10 | 2:30PM - 4:30PM
Workshop 3: Peptides as Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 2 of 9
Anne-Mette Bjerregaard, Technical University of Denmark, Denmark
MuPeXI: A Tool for Prediction of Neo-Epitopes from Tumor Sequencing Data


Thursday, March 10 | 2:30PM - 4:30PM
Workshop 3: Peptides as Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 3 of 9
Gustav Gaudernack, Ultimovacs AS/Norwegian Radium Hospital, Norway
UV1 – A Second-Generation, Peptide-Based, Therapeutic Cancer Vaccine (TCV) Targeting the Reverse Transcriptase Subunit of Human Telomerase (hTERT


Thursday, March 10 | 2:30PM - 4:30PM
Workshop 3: Peptides as Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 4 of 9
Matthew M. Gubin, Washington University in St. Louis, USA
Tumor-Specific Mutant Antigens in Cancer Immunotherapy


Thursday, March 10 | 2:30PM - 4:30PM
Workshop 3: Peptides as Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 5 of 9
Bruno Laugel, Institut De Recherche Servier, France
Safety Assessment of DNA Methyl Transferase Inhibitors in Combination with NY-ESO T-cell Therapy.


Thursday, March 10 | 2:30PM - 4:30PM
Workshop 3: Peptides as Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 6 of 9
Aizea Morales Kastresana, NCI, National Institutes of Health, USA
Optimization of Extracellular Vesicle Labels for NanoFACS


Thursday, March 10 | 2:30PM - 4:30PM
Workshop 3: Peptides as Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 7 of 9
Hideho Okada, University of California, San Francisco, USA
Novel and Shared Neoantigen for Glioma T Cell Therapy Derived from Histone 3 Variant H3.3 K27M Mutation


Thursday, March 10 | 2:30PM - 4:30PM
Workshop 3: Peptides as Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 8 of 9
Jeffrey Ward, Washington University School of Medicine, USA
Tumor Mutant Antigen-Specific CD8+ T-cells Require CD4+ T-cell Help to Induce Tumor Regression


Thursday, March 10 | 2:30PM - 4:30PM
Workshop 3: Peptides as Vaccines
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 9 of 9
Klaus Früh, Oregon Health & Science University, USA
CMV-induced MHC-II and MHC-E-Restricted CD8+ T Cells: A Role in Cancer Immunotherapy


Thursday, March 10 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Thursday, March 10 | 5:00PM - 6:45PM
Antibodies for the Treatment of Infectious Diseases
Room: Macdonald ABC

Speaker 1 of 2
Leo James, MRC Laboratory of Molecular Biology, UK
Intracellular Antibody Immunity and the Cytosolic Fc Receptor TRIM21

Thursday, March 10 | 5:00PM - 6:45PM
Antibodies for the Treatment of Infectious Diseases
Room: Macdonald ABC

Speaker 2 of 2
Carole A. Bewley, National Institutes of Health, USA
Antibody-like Properties and Functions of Antiviral Carbohydrate Binding Proteins

Thursday, March 10 | 5:00PM - 6:45PM
Linking Cancer Genetics and Genomics with Immunity
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 1 of 4
* Hyam I. Levitsky, Century Therapeutics, USA


Thursday, March 10 | 5:00PM - 6:45PM
Linking Cancer Genetics and Genomics with Immunity
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 2 of 4
Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Genomics of Human Immune Response


Thursday, March 10 | 5:00PM - 6:45PM
Linking Cancer Genetics and Genomics with Immunity
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 3 of 4
Robert D. Schreiber, Washington University School of Medicine, USA
Cancer-Specific Mutations as Tumor Rejection Antigens


Thursday, March 10 | 5:00PM - 6:45PM
Linking Cancer Genetics and Genomics with Immunity
This session is from Cancer Vaccines
Room: Macdonald DEF

Speaker 4 of 4
Catherine J. Wu, Dana-Farber Cancer Institute, USA
Targeting Tumor Neoantigens: Developing Personalized Cancer Vaccines


Thursday, March 10 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Macdonald ABC


Thursday, March 10 | 6:45PM - 7:00PM
The Human Vaccines Project: A Roadmap to Effective Cancer Va
ccine and Immunotherapeutic Development
This session is from Cancer Vaccines

Room: Macdonald DEF

Speaker 1 of 2
* A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA


Thursday, March 10 | 6:45PM - 7:00PM
The Human Vaccines Project: A Roadmap to Effective Cancer Va
ccine and Immunotherapeutic Development
This session is from Cancer Vaccines

Room: Macdonald DEF

Speaker 2 of 2
Theodore Schenkelberg, Human Vaccines Project, USA


Thursday, March 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac
No registration fees are used to fund alcohol served at this function.

Thursday, March 10 | 8:00PM - 11:00PM
Entertainment
Room: Frontenac
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 10 | 8:00PM - 11:00PM
Cash Bar
Room: Frontenac


Friday, March 11 | 5:25AM - 5:25PM
Departure


*Session Chair.