Web Desc
NF-kappaB and MAP Kinase Signaling in Inflammation
joint with Ubiquitin Signaling
Organizer(s): Steven C. Ley, Zhijian 'James' Chen and Jenny P.Y. Ting
Date: March 13 - 17, 2016
Location: Whistler Conference Centre, Whistler, BC, Canada
Sponsored by Genentech, Inc.
Summary of Meeting:
Dysregulated inflammatory responses underlie many major diseases, including arthritis, psoriasis, inflammatory bowel disease, atherosclerosis, metabolic disease and cancer. Consequently, there is considerable interest in the pharmaceutical industry in targeting the signaling pathways regulating inflammation as a potential therapeutic approach for treatment of these diseases. Gene expression during inflammatory responses is controlled by NF-kappaB transcription factors, IRF transcription factors and each of the major MAP kinase subtypes (ERK1/2, JNK and p38) in innate immune cells. This symposium will focus on the role of ubiquitination in regulating NF-kappaB and MAP kinase activation, and how NF-kappaB-dependent transcription is coordinated with IRF activation and MAP kinase signaling to control innate immunity. Progress in the therapeutic targeting of NF-kappaB and MAP kinase activation pathways for treatment of chronic inflammatory diseases and cancer will also be discussed.
Scholarship Deadline: November 11 2015
Discounted Abstract Deadline: November 11 2015
Abstract Deadline: December 14 2015
Discounted Registration Deadline: January 13 2016
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Genentech, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

Pfizer Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI122450-01
Funding for this conference was made possible (in part) by 1 R13 AI 122450 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 13 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sea to Sky Foyer


Sunday, March 13 | 6:00PM - 8:00PM
Welcome Mixer
Room: Sea to Sky Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 14 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Monday, March 14 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 1 of 4
* Steven C. Ley, Francis Crick Institute, UK

Monday, March 14 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 2 of 4
* Michael Rape, University of California, Berkeley, USA

Monday, March 14 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 3 of 4
Louis M. Staudt, NCI, National Institutes of Health, USA
Blocking NF-kappaB Activation as a Therapeutic Approach in Cancer

Monday, March 14 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 4 of 4
Ning Zheng, University of Washington, USA
Targeting Regulatory Enzymes in Ubiquitin Signaling

Monday, March 14 | 9:30AM - 9:50AM
Coffee Break
Room: Grand Foyer


Monday, March 14 | 9:50AM - 11:30AM
NF-kappaB Signaling in Cancer
Room: Sea to Sky C

Speaker 1 of 4
* Louis M. Staudt, NCI, National Institutes of Health, USA

Monday, March 14 | 9:50AM - 11:30AM
NF-kappaB Signaling in Cancer
Room: Sea to Sky C

Speaker 2 of 4
Michael Karin, University of California, San Diego, USA
How NF-kappaB Orchestrates Inflammation

Monday, March 14 | 9:50AM - 11:30AM
NF-kappaB Signaling in Cancer
Room: Sea to Sky C

Speaker 3 of 4
Daniel Krappmann, Helmholtz Zentrum München, Germany
CARMA1-BCL10-MALT1 Signaling in Adaptive Immunity and Lymphoma

Monday, March 14 | 9:50AM - 11:30AM
NF-kappaB Signaling in Cancer
Room: Sea to Sky C

Speaker 4 of 4
Dinis P. Calado, Francis Crick Institute, UK
NF-kappaB Cooperating Events in Mature B Cell-Derived Malignancies

Monday, March 14 | 9:50AM - 11:30AM
Regulation of the Ubiquitin System by Deubiquitylases and Ph
osphorylation
This session is from Ubiquitin Signaling

Room: Sea to Sky B

Speaker 1 of 4
* Philip Cohen, University of Dundee, UK


Monday, March 14 | 9:50AM - 11:30AM
Regulation of the Ubiquitin System by Deubiquitylases and Ph
osphorylation
This session is from Ubiquitin Signaling

Room: Sea to Sky B

Speaker 2 of 4
Titia K. Sixma, Netherlands Cancer Institute, Netherlands
Controlling the Isopeptidases: Regulation of Deubiquitination Reactions


Monday, March 14 | 9:50AM - 11:30AM
Regulation of the Ubiquitin System by Deubiquitylases and Ph
osphorylation
This session is from Ubiquitin Signaling

Room: Sea to Sky B

Speaker 3 of 4
Mads Gyrd-Hansen, University of Oxford, UK
CYLD limits Lys63- and Met1-linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling


Monday, March 14 | 9:50AM - 11:30AM
Regulation of the Ubiquitin System by Deubiquitylases and Ph
osphorylation
This session is from Ubiquitin Signaling

Room: Sea to Sky B

Speaker 4 of 4
Richard J. Youle, NINDS, National Institutes of Health, USA
Ubiquitin Signals on Mitochondria Promote Mitophagy via Autophagy Receptors


Monday, March 14 | 11:30AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Monday, March 14 | 11:30AM - 2:30PM
On Own for Lunch


Monday, March 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Monday, March 14 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 1 of 9
* Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 2 of 9
* Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 3 of 9
Jian Zhang, Ohio State University, USA
Anti-Fungal Innate Immune Response Mediated by C-Type Lectin Receptors Dectin-1 and Dectin-2 Is Regulated by E3 Ubiquitin Ligase Cbl-b

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 4 of 9
Claire Tocheny, National Institutes of Health, USA
Inflammatory Disease and Immunodeficiency due to Mutation in IkappaBalpha

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 5 of 9
Marc Riemann, Leibniz Institute on Aging - Fritz Lipmann Institute, Germany
Classical NF-kappaB Signaling via RelA and c-Rel Controls the Development of Medullary Thymic Epithelial Cells

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 6 of 9
Firaz Mohideen, Harvard Medical School, USA
Systematic Quantitative Proteomics in Response to TNFalpha Signaling Reveals Dynamic Alterations in the Architecture of the Cellular Phospho-proteome

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 7 of 9
Isabel Meininger, Helmholtz Zentrum München, Germany
Alternative Splicing of MALT1 is Critical for Signaling and Activation of CD4+ T Cells

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 8 of 9
Meri Kaustio, FIMM/University of Helsinki, Finland
Heterozygous Mutations in NFKB1 cause Immunodeficiency and Autoinflammation

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 9 of 9
Mélanie Juilland, University of Lausanne, Switzerland
CARMA1- and MyD88-Dependent Activation of Specific AP-1 Complexes is a Hallmark of ABC Diffuse Large B-cell Lymphomas

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Structural Biology and Biochemistry of Ubiquityl
ation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 1 of 7
* Rachel Klevit, University of Washington, USA


Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Structural Biology and Biochemistry of Ubiquityl
ation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 2 of 7
Maria Sunnerhagen, Linkoping University, Sweden
Structure of a TRIM21 - UBE2E1 Complex Reveals the Specificity of E2, Ubiquitin and Substrate Recognition by TRIM E3 RINGs


Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Structural Biology and Biochemistry of Ubiquityl
ation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 3 of 7
Katrin E. Rittinger, Francis Crick Institute, UK
Structural and Functional Characterization of TRIM Family E3 Ligases


Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Structural Biology and Biochemistry of Ubiquityl
ation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 4 of 7
Catherine L. Day, University of Otago, New Zealand
Activation of Ubiquitin Transfer by Secondary Ubiquitin–RING Docking


Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Structural Biology and Biochemistry of Ubiquityl
ation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 5 of 7
Seth F. Harris, Genentech, Inc., USA
Structural Insights Into WD-Repeat 48 Activation of Ubiquitin Specific Protease 46


Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Structural Biology and Biochemistry of Ubiquityl
ation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 6 of 7
Aysegul Ozen, Genentech, Inc., USA
Engineering the USP7 Catalytic Domain for Activity


Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Structural Biology and Biochemistry of Ubiquityl
ation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 7 of 7
Hirotaka Takahashi, Ehime University, Japan
Establishment of Deubiquitinating Enzyme Protein Array Based on Wheat Cell-Free System for a Novel Biochemical Tool


Monday, March 14 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Monday, March 14 | 5:00PM - 7:00PM
NF-kappaB Signaling in Immunity
Room: Sea to Sky C

Speaker 1 of 4
* Manolis Pasparakis, University of Cologne, Germany
The Interplay between NEMO, NF-kB and RIPK1 in Cell Death and Inflammation

Monday, March 14 | 5:00PM - 7:00PM
NF-kappaB Signaling in Immunity
Room: Sea to Sky C

Speaker 2 of 4
Steve D. Gerondakis, Monash University, Australia
Is NF-kappaB1 a Tumor Suppressor?

Monday, March 14 | 5:00PM - 7:00PM
NF-kappaB Signaling in Immunity
Room: Sea to Sky C

Speaker 3 of 4
Xiaoxia Li, Cleveland Clinic Foundation, USA
IRAK Regulation of NF-kappaB and MAP Kinase Activation

Monday, March 14 | 5:00PM - 7:00PM
NF-kappaB Signaling in Immunity
Room: Sea to Sky C

Speaker 4 of 4
* Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA
Short Talk: The B-Cell Tumor Promoter Bcl-3 Controls Inflammation-Associated Colon Tumorigenesis

Monday, March 14 | 5:00PM - 7:00PM
Role of Ubiquitylation in Control of Autophagy
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 1 of 5
* Richard J. Youle, NINDS, National Institutes of Health, USA


Monday, March 14 | 5:00PM - 7:00PM
Role of Ubiquitylation in Control of Autophagy
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 2 of 5
James H. Hurley, University of California, Berkeley, USA
Mechanistic and Structural Insights into Autophagy Initiation


Monday, March 14 | 5:00PM - 7:00PM
Role of Ubiquitylation in Control of Autophagy
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 3 of 5
J. Wade Harper, Harvard Medical School, USA
Ubiquitin Signaling for Mitophagy


Monday, March 14 | 5:00PM - 7:00PM
Role of Ubiquitylation in Control of Autophagy
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 4 of 5
Ivan Dikic, Goethe University Medical School, Germany
Ubiquitin Regulation of Selective Autophagy


Monday, March 14 | 5:00PM - 7:00PM
Role of Ubiquitylation in Control of Autophagy
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 5 of 5
Xavier Jacq, MISSION Therapeutics Ltd., UK
Short Talk: Inhibitors of USP30 as a Potential Treatment of Parkinson’s disease and Other Mitochondrial Dysfunctions


Monday, March 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Monday, March 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Tuesday, March 15 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Tuesday, March 15 | 7:30AM - 8:00AM
Poster Setup
Room: Sea to Sky A


Tuesday, March 15 | 8:00AM - 5:00PM
Poster Viewing
Room: Sea to Sky A


Tuesday, March 15 | 8:00AM - 11:00AM
Ubiquitination-Dependent Modulation of NF-kappaB Signaling I
(Joint)

Room: Sea to Sky B/C

Speaker 1 of 6
* Vishva M. Dixit, Genentech, Inc., USA

Tuesday, March 15 | 8:00AM - 11:00AM
Ubiquitination-Dependent Modulation of NF-kappaB Signaling I
(Joint)

Room: Sea to Sky B/C

Speaker 2 of 6
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Regulation of Antiviral Innate Immunity by Ubiquitination and Phosphorylation

Tuesday, March 15 | 8:00AM - 11:00AM
Ubiquitination-Dependent Modulation of NF-kappaB Signaling I
(Joint)

Room: Sea to Sky B/C

Speaker 3 of 6
Pascal Meier, Institute of Cancer Research, UK
Tipping the Response to TNF in Favor of Death

Tuesday, March 15 | 8:00AM - 11:00AM
Ubiquitination-Dependent Modulation of NF-kappaB Signaling I
(Joint)

Room: Sea to Sky B/C

Speaker 4 of 6
Domagoj Vucic, Genentech, Inc., USA
Short Talk: Ubiquitin Ligase Activity of XIAP Regulates NOD2 Mediated Inflammatory Signaling

Tuesday, March 15 | 8:00AM - 11:00AM
Ubiquitination-Dependent Modulation of NF-kappaB Signaling I
(Joint)

Room: Sea to Sky B/C

Speaker 5 of 6
Michaela U. Gack, University of Chicago, USA
Regulation of Antiviral Signaling by TRIM E3 Ligases

Tuesday, March 15 | 8:00AM - 11:00AM
Ubiquitination-Dependent Modulation of NF-kappaB Signaling I
(Joint)

Room: Sea to Sky B/C

Speaker 6 of 6
David Komander, Walter and Eliza Hall Institute of Medical Research, Australia
Regulating Linear Ubiquitin Chains with OTULIN

Tuesday, March 15 | 9:40AM - 10:00AM
Coffee Break
Room: Grand Foyer


Tuesday, March 15 | 11:00AM - 12:00PM
Lunch
Room: Sea to Sky A


Tuesday, March 15 | 12:00PM - 2:30PM
Poster Session 2
Room: Sea to Sky A


Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Physiology of Ubiquitin-Dependent Signaling
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 1 of 8
* Michael Rape, University of California, Berkeley, USA


Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Physiology of Ubiquitin-Dependent Signaling
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 2 of 8
Pieter J. Eichhorn, National University Singapore, Singapore
USP15 Regulates SMURF2 Kinetics through C-Lobe Mediated Deubiquitination


Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Physiology of Ubiquitin-Dependent Signaling
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 3 of 8
Tohru Ishitani, Medical Institute of Bioregulation, Kyushu University, Japan
Ubiquitin-Mediated NF-kappaB Degradation Directs Dorsal-Ventral Patterning in Vertebrate Early Embryo


Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Physiology of Ubiquitin-Dependent Signaling
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 4 of 8
Brooke L. Latour, Radboudumc, Netherlands
De novo Loss of Function Mutations in the Deubiquitinating Enzyme USP9X cause a Female Specific Syndrome Characterized by Developmental Delay and Distinct Congenital Malformations


Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Physiology of Ubiquitin-Dependent Signaling
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 5 of 8
Eli Arama, Weizmann Institute of Science, Israel
Spatial Regulation of a CRL3 Complex by a Krebs Cycle Component Restricts Caspase Activation to the Vicinity of the Mitochondria during a Non-apoptotic Cellular Process in Drosophila


Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Physiology of Ubiquitin-Dependent Signaling
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 6 of 8
Steven H. Spoel, University of Edinburgh, UK
Transcriptional Activation by E3 and E4 Ubiquitin Ligases


Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Physiology of Ubiquitin-Dependent Signaling
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 7 of 8
Alexandra Greer, Genentech, Inc., USA
Ubiquilin1 is Uniquely Required for Cell Cycle Entry and Proliferation Downstream of B-cell Receptor Signaling


Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Physiology of Ubiquitin-Dependent Signaling
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 8 of 8
Satpal Virdee, University of Dundee, UK
Engineered E2~Ub Conjugates as Probes of E3 ligase Transthiolation Activity


Tuesday, March 15 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Tuesday, March 15 | 5:00PM - 7:00PM
Transcriptional Regulation in Inflammation
Room: Sea to Sky C

Speaker 1 of 5
* Michael Karin, University of California, San Diego, USA

Tuesday, March 15 | 5:00PM - 7:00PM
Transcriptional Regulation in Inflammation
Room: Sea to Sky C

Speaker 2 of 5
Alexander Hoffmann, University of California, Los Angeles, USA
Dynamic Control of NFkB

Tuesday, March 15 | 5:00PM - 7:00PM
Transcriptional Regulation in Inflammation
Room: Sea to Sky C

Speaker 3 of 5
Irina A. Udalova, University of Oxford, UK
IRF5 Orchestrated Regulation of Inflammatory Programme in Macrophages

Tuesday, March 15 | 5:00PM - 7:00PM
Transcriptional Regulation in Inflammation
Room: Sea to Sky C

Speaker 4 of 5
Neal Silverman, University of Massachusetts Medical School, USA
Short Talk: Regulation of Drosophila Innate Immune NF-kappaB Signaling by Amyloidal Proteins

Tuesday, March 15 | 5:00PM - 7:00PM
Transcriptional Regulation in Inflammation
Room: Sea to Sky C

Speaker 5 of 5
Stephen T. Smale, University of California, Los Angeles, USA
Global Analysis of Transcriptional Cascades Induced by Inflammatory Stimuli

Tuesday, March 15 | 5:00PM - 7:00PM
Large Machines
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 1 of 5
* Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany


Tuesday, March 15 | 5:00PM - 7:00PM
Large Machines
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 2 of 5
Andreas Martin, University of California, Berkeley, USA
26S Proteasome Assembly and Conformational Changes Control Substrate Deubiquitination by Rpn11


Tuesday, March 15 | 5:00PM - 7:00PM
Large Machines
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 3 of 5
Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research, Switzerland
Regulation of Cullin-RING-ligase activity by CSN


Tuesday, March 15 | 5:00PM - 7:00PM
Large Machines
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 4 of 5
Raymond J. Deshaies, Amgen, Inc., USA
Regulation of CRL Assembly: The Adaptive Exchange Hypothesis


Tuesday, March 15 | 5:00PM - 7:00PM
Large Machines
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 5 of 5
Jessica A. Gasser, Broad Institute of MIT and Harvard, USA
Short Talk: Genome-Wide CRISPR-Cas9 Screen Reveals Genes Required for the Effect of Lenalidomide on the CRL4-CRBN Ubiquitin Ligase


Tuesday, March 15 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, March 16 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Wednesday, March 16 | 8:00AM - 11:00AM
NLR Signaling to NF-kappaB and IRF
Room: Sea to Sky C

Speaker 1 of 6
* Rudi Beyaert, Ghent University - VIB, Belgium

Wednesday, March 16 | 8:00AM - 11:00AM
NLR Signaling to NF-kappaB and IRF
Room: Sea to Sky C

Speaker 2 of 6
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs as Regulators of NFkappaB and MAPK Signaling

Wednesday, March 16 | 8:00AM - 11:00AM
NLR Signaling to NF-kappaB and IRF
Room: Sea to Sky C

Speaker 3 of 6
Feng Shao, National Institute of Biological Sciences, China
Pyroptosis in Anti-Bacterial Immunity: Sensing and Execution

Wednesday, March 16 | 8:00AM - 11:00AM
NLR Signaling to NF-kappaB and IRF
Room: Sea to Sky C

Speaker 4 of 6
Benedict Seddon, University College London, UK
Short Talk: TNF Activation of NF-kappaB is Essential for Development of Single Positive Thymocytes

Wednesday, March 16 | 8:00AM - 11:00AM
NLR Signaling to NF-kappaB and IRF
Room: Sea to Sky C

Speaker 5 of 6
Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Regulators of Inflammatory Responses

Wednesday, March 16 | 8:00AM - 11:00AM
NLR Signaling to NF-kappaB and IRF
Room: Sea to Sky C

Speaker 6 of 6
Vishva M. Dixit, Genentech, Inc., USA
RIPK3: Role of the Kinase Activity in Necroptosis

Wednesday, March 16 | 8:00AM - 11:00AM
Ubiquitylation and Human Disease
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 1 of 6
* Ingrid E. Wertz, Genentech, Inc., USA


Wednesday, March 16 | 8:00AM - 11:00AM
Ubiquitylation and Human Disease
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 2 of 6
Michael Rape, University of California, Berkeley, USA
Ubiquitin-Dependent Regulation of Craniofacial Development


Wednesday, March 16 | 8:00AM - 11:00AM
Ubiquitylation and Human Disease
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 3 of 6
Dario Alessi, University of Dundee, UK
Control of Blood Pressure


Wednesday, March 16 | 8:00AM - 11:00AM
Ubiquitylation and Human Disease
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 4 of 6
Noam Zelcer, Academic Medical Center, University of Amsterdam, Netherlands
Short Talk: USP2 Regulates the LDLR Pathway through Deubiquitylation of the E3-ubiquitin Ligase IDOL


Wednesday, March 16 | 8:00AM - 11:00AM
Ubiquitylation and Human Disease
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 5 of 6
Heran Darwin, New York University School of Medicine, USA
Proteasomal Regulation of Mycobacterium tuberculosis Pathogenesis


Wednesday, March 16 | 8:00AM - 11:00AM
Ubiquitylation and Human Disease
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 6 of 6
Jeffery S. Cox, University of California, Berkeley, USA
Discrimination of Pathogens from Non-Pathogens by Innate Immune Cells


Wednesday, March 16 | 9:40AM - 10:00AM
Coffee Break
Room: Grand Foyer


Wednesday, March 16 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Wednesday, March 16 | 11:00AM - 2:30PM
On Own for Lunch


Wednesday, March 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 1 of 9
* Steve D. Gerondakis, Monash University, Australia

Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 2 of 9
* Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA

Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 3 of 9
Simon Rousseau, McGill University, Canada
Differential Contributions of theTPL2-MKK1/MKK2-ERK1/ERK2 and NFkB Pathways to Oncogenic Transformation in Lymphoid Neoplasms

Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 4 of 9
Nadine Mikuda, Max-Delbrück-Center for Molecular Medicine, MDC, Germany
The IkappaB Kinase Complex is a Universal Regulator of mRNA Stability in Response to Stress

Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 5 of 9
Marina Kolesnichenko, Max Delbrueck Center for Molecular Medicine, Germany
Senescence Associated NFkappaB Inflammatory Response is Driven by an mRNA Destabilization Mechanism

Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 6 of 9
Benjamin E. Gewurz, Brigham and Women's Hospital, Harvard Medical School, USA
The NF-kB Genomic Landscape in CD40-Stimulated Primary Human B-cells

Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 7 of 9
Anetta Svitorka Härtlova, University of Gothenburg, Sweden
Scavenger Receptor MSR-JNK Pathway Control Phenotypic Switch of Alternatively Activated Macrophages

Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 8 of 9
Ricardo Antonia, University of North Carolina, USA
IKK Promotes AMPK Activity by Phosphorylating Threonine 172 in Response to IL-1beta

Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 9 of 9
Ruaidhri Carmody, University of Glasgow, UK
Control of MAP Kinase and NF-kappaB Pathways by the Nuclear IkappaB-like factor Bcl-3

Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 3: The Interplay between Ubiquitylation and Phospho
rylation in Cell Regulation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 1 of 7
* David Komander, Walter and Eliza Hall Institute of Medical Research, Australia


Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 3: The Interplay between Ubiquitylation and Phospho
rylation in Cell Regulation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 2 of 7
Maria Isabel Acosta Lopez, University of Nice Sophia Antipolis, France
New Regulatory Mechanism and Cellular Function of the Tumor Suppressor HACE1


Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 3: The Interplay between Ubiquitylation and Phospho
rylation in Cell Regulation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 3 of 7
Niall Dillon, Medical Research Council, UK
Phosphorylation of the E2 Ubiquitin Conjugating Enzyme UBE2D3 Regulates Polycomb-Mediated Gene Priming in Pluripotent ES Cells


Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 3: The Interplay between Ubiquitylation and Phospho
rylation in Cell Regulation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 4 of 7
Jeffrey R. Johnson, University of California, San Francisco, USA
Ubiquitin Remnant Profiling Identifies a Novel Substrate of HIV-Mediated Ubiquitination and Degradation


Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 3: The Interplay between Ubiquitylation and Phospho
rylation in Cell Regulation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 5 of 7
R. Jeremy Nichols, Parkinson's Institute, USA
The LRRK2 Phosphorylation-Ubiquitination Cycle


Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 3: The Interplay between Ubiquitylation and Phospho
rylation in Cell Regulation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 6 of 7
Camillo Palmieri, Università Magna Grecia of Catanzaro, Italy
Regulation of IBtk-alpha Activity by mTOR-Mediated Phosphorylation


Wednesday, March 16 | 2:30PM - 4:30PM
Workshop 3: The Interplay between Ubiquitylation and Phospho
rylation in Cell Regulation
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 7 of 7
Nicolas Bidère, INSERM, France
The Paracaspase MALT1 Cleaves the LUBAC Subunit HOIL1 during Antigen Receptor Signaling


Wednesday, March 16 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Wednesday, March 16 | 5:00PM - 7:00PM
MAP Kinase Signaling in Inflammation
Room: Sea to Sky C

Speaker 1 of 5
* Xiaoxia Li, Cleveland Clinic Foundation, USA

Wednesday, March 16 | 5:00PM - 7:00PM
MAP Kinase Signaling in Inflammation
Room: Sea to Sky C

Speaker 2 of 5
Steven C. Ley, Francis Crick Institute, UK
Regulation of Inflammation by TPL-2 MAP 3-kinase

Wednesday, March 16 | 5:00PM - 7:00PM
MAP Kinase Signaling in Inflammation
Room: Sea to Sky C

Speaker 3 of 5
Ana Cuenda, Spanish National Biotechnology Centre, Spain
Regulation of Inflammation by p38gamma/delta

Wednesday, March 16 | 5:00PM - 7:00PM
MAP Kinase Signaling in Inflammation
Room: Sea to Sky C

Speaker 4 of 5
Mathieu JM Bertrand, VIB / Ghent University, Belgium
Short Talk: NF-kB-Independent Role of IKKa/IKKb in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

Wednesday, March 16 | 5:00PM - 7:00PM
MAP Kinase Signaling in Inflammation
Room: Sea to Sky C

Speaker 5 of 5
Roger J. Davis, HHMI/University of Massachusetts Medical School, USA
Role of JNK in Metabolic Stress Signaling

Wednesday, March 16 | 5:00PM - 7:00PM
Structural Analysis of E3 Ligases and DUBs
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 1 of 5
* Titia K. Sixma, Netherlands Cancer Institute, Netherlands


Wednesday, March 16 | 5:00PM - 7:00PM
Structural Analysis of E3 Ligases and DUBs
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 2 of 5
Rachel Klevit, University of Washington, USA
Mechanistic Strategies of RING-Between-RING (RBR) E3 Ligases


Wednesday, March 16 | 5:00PM - 7:00PM
Structural Analysis of E3 Ligases and DUBs
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 3 of 5
Bernhard Clemens Lechtenberg, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Structure of the HOIP-RBR/E2~ubiquitin Transfer Complex Reveals a Universal Mechanism for RBR E3 Ubiquitin Ligases


Wednesday, March 16 | 5:00PM - 7:00PM
Structural Analysis of E3 Ligases and DUBs
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 4 of 5
Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Cullin-RING E3 Ligation Mechanisms


Wednesday, March 16 | 5:00PM - 7:00PM
Structural Analysis of E3 Ligases and DUBs
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 5 of 5
Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA
E3 Ligases: Activities and Specificity


Wednesday, March 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Wednesday, March 16 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky A


Thursday, March 17 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Thursday, March 17 | 8:00AM - 11:00AM
Therapeutic Targeting of Inflammation
Room: Sea to Sky C

Speaker 1 of 5
* Daniel Krappmann, Helmholtz Zentrum München, Germany

Thursday, March 17 | 8:00AM - 11:00AM
Therapeutic Targeting of Inflammation
Room: Sea to Sky C

Speaker 2 of 5
Stefan Knapp, University of Oxford, UK
Targeting Bromodomains in Inflammation

Thursday, March 17 | 8:00AM - 11:00AM
Therapeutic Targeting of Inflammation
Room: Sea to Sky C

Speaker 3 of 5
Vanessa C. Taylor, Rigel Inc., USA
R191, A Small Molecule IRAK1/4 Kinase Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases

Thursday, March 17 | 8:00AM - 11:00AM
Therapeutic Targeting of Inflammation
Room: Sea to Sky C

Speaker 4 of 5
Eric P. Hanson, National Institutes of Health, USA
Short Talk: Recruitment of A20 by the C-Terminal Domain of NEMO Suppresses NF-kappaB Activation and Autoinflammatory Disease

Thursday, March 17 | 8:00AM - 11:00AM
Therapeutic Targeting of Inflammation
Room: Sea to Sky C

Speaker 5 of 5
Vikram R. Rao, Pfizer, USA
The Role of IRAK4 in NFkB and MAPK Signaling: Implications for Drug Development

Thursday, March 17 | 8:00AM - 11:00AM
Small Molecules and Therapeutics
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 1 of 6
* Raymond J. Deshaies, Amgen, Inc., USA


Thursday, March 17 | 8:00AM - 11:00AM
Small Molecules and Therapeutics
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 2 of 6
Zhihao Zhuang, University of Delaware, USA
Targeting Deubiquitinase in DNA Damage Response for Anticancer Therapy


Thursday, March 17 | 8:00AM - 11:00AM
Small Molecules and Therapeutics
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 3 of 6
Alessio Ciulli, University of Dundee, School of Life Sciences, UK
Short Talk: Small Molecules for the VHL Cul2 E3 Ligase: VHL-HIF Inhibitors and Proteolysis Targeting Chimeras (PROTACs)


Thursday, March 17 | 8:00AM - 11:00AM
Small Molecules and Therapeutics
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 4 of 6
Georg Petzold, Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: Structural Basis of Lenalidomide-induced CK1alpha Degradation by the CRL4-CRBN Ubiquitin Ligase


Thursday, March 17 | 8:00AM - 11:00AM
Small Molecules and Therapeutics
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 5 of 6
Ingrid E. Wertz, Genentech, Inc., USA
Phosphorylation and Linear Ubiquitin Direct A20 Inhibition of Inflammation


Thursday, March 17 | 8:00AM - 11:00AM
Small Molecules and Therapeutics
This session is from Ubiquitin Signaling
Room: Sea to Sky B

Speaker 6 of 6
Frank Sicheri, Lunenfeld-Tanenbaum Research Institute, Canada
The Structural basis for Poly-Ubiquitin Chain Cleavage and Regulation: Lessons Learned from BRCC36


Thursday, March 17 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Thursday, March 17 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, March 17 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Thursday, March 17 | 5:00PM - 7:15PM
Ubiquitin-Dependent Modulation of NF-kappaB Signaling II (Jo
int)

Room: Sea to Sky B/C

Speaker 1 of 5
* Ivan Dikic, Goethe University Medical School, Germany

Thursday, March 17 | 5:00PM - 7:15PM
Ubiquitin-Dependent Modulation of NF-kappaB Signaling II (Jo
int)

Room: Sea to Sky B/C

Speaker 2 of 5
Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA
Epigenetic Regulation of NF-kB Function and Inflammation by Ubiquitination

Thursday, March 17 | 5:00PM - 7:15PM
Ubiquitin-Dependent Modulation of NF-kappaB Signaling II (Jo
int)

Room: Sea to Sky B/C

Speaker 3 of 5
Shigeki Miyamoto, University of Wisconsin, Madison, USA
Investigation of NF-kappaB Signaling Induced by Genotoxic Agents and Potentially Novel Activators

Thursday, March 17 | 5:00PM - 7:15PM
Ubiquitin-Dependent Modulation of NF-kappaB Signaling II (Jo
int)

Room: Sea to Sky B/C

Speaker 4 of 5
Rudi Beyaert, Ghent University - VIB, Belgium
The Dual Faces of Paracaspase MALT1 in Inflammation and Immunity

Thursday, March 17 | 5:00PM - 7:15PM
Ubiquitin-Dependent Modulation of NF-kappaB Signaling II (Jo
int)

Room: Sea to Sky B/C

Speaker 5 of 5
Philip Cohen, University of Dundee, UK
Re-Writing the Interleukin-1 Signaling Network

Thursday, March 17 | 7:15PM - 7:30PM
Meeting Wrap-Up: Outcomes and Future Directions (Joint)
Room: Sea to Sky B/C

Speaker 1 of 1
Philip Cohen, University of Dundee, UK

Thursday, March 17 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Thursday, March 17 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 17 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Friday, March 18 | 10:25AM - 10:25AM
Departure


*Session Chair.