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Web Desc
NF-kappaB and MAP Kinase Signaling in Inflammation joint with Ubiquitin Signaling Organizer(s): Steven C. Ley, Zhijian 'James' Chen and Jenny P.Y. Ting Date: March 13 - 17, 2016 Location: Whistler Conference Centre, Whistler, BC, Canada Sponsored by Genentech, Inc. Summary of Meeting: Dysregulated inflammatory responses underlie many major diseases, including arthritis, psoriasis, inflammatory bowel disease, atherosclerosis, metabolic disease and cancer. Consequently, there is considerable interest in the pharmaceutical industry in targeting the signaling pathways regulating inflammation as a potential therapeutic approach for treatment of these diseases. Gene expression during inflammatory responses is controlled by NF-kappaB transcription factors, IRF transcription factors and each of the major MAP kinase subtypes (ERK1/2, JNK and p38) in innate immune cells. This symposium will focus on the role of ubiquitination in regulating NF-kappaB and MAP kinase activation, and how NF-kappaB-dependent transcription is coordinated with IRF activation and MAP kinase signaling to control innate immunity. Progress in the therapeutic targeting of NF-kappaB and MAP kinase activation pathways for treatment of chronic inflammatory diseases and cancer will also be discussed. Scholarship Deadline: November 11 2015 Discounted Abstract Deadline: November 11 2015 Abstract Deadline: December 14 2015 Discounted Registration Deadline: January 13 2016 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Genentech, Inc. Pfizer Inc. We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1R13AI122450-01 Funding for this conference was made possible (in part) by 1 R13 AI 122450 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

NF-kappaB and MAP Kinase Signaling in Inflammation

joint with Ubiquitin Signaling

Organizer(s): Steven C. Ley, Zhijian 'James' Chen and Jenny P.Y. Ting

Date: March 13 - 17, 2016
Location: Whistler Conference Centre, Whistler, BC, Canada

Program


Sunday, March 13 \| 4:00PM - 8:00PM Arrival and Registration Room: Sea to Sky Foyer
Sunday, March 13 \| 6:00PM - 8:00PM Welcome Mixer Room: Sea to Sky Foyer No registration fees are used to fund alcohol served at this function.
Monday, March 14 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky A
Monday, March 14 \| 8:00AM - 9:30AM Keynote Session (Joint) Room: Sea to Sky B/C Speaker 1 of 4 * Steven C. Ley, Francis Crick Institute, UK
Monday, March 14 \| 8:00AM - 9:30AM Keynote Session (Joint) Room: Sea to Sky B/C Speaker 2 of 4 * Michael Rape, University of California, Berkeley, USA
Monday, March 14 \| 8:00AM - 9:30AM Keynote Session (Joint) Room: Sea to Sky B/C Speaker 3 of 4 Louis M. Staudt, NCI, National Institutes of Health, USA Blocking NF-kappaB Activation as a Therapeutic Approach in Cancer
Monday, March 14 \| 8:00AM - 9:30AM Keynote Session (Joint) Room: Sea to Sky B/C Speaker 4 of 4 Ning Zheng, University of Washington, USA Targeting Regulatory Enzymes in Ubiquitin Signaling
Monday, March 14 \| 9:30AM - 9:50AM Coffee Break Room: Grand Foyer
Monday, March 14 \| 9:50AM - 11:30AM NF-kappaB Signaling in Cancer Room: Sea to Sky C Speaker 1 of 4 * Louis M. Staudt, NCI, National Institutes of Health, USA
Monday, March 14 \| 9:50AM - 11:30AM NF-kappaB Signaling in Cancer Room: Sea to Sky C Speaker 2 of 4 Michael Karin, University of California, San Diego, USA How NF-kappaB Orchestrates Inflammation
Monday, March 14 \| 9:50AM - 11:30AM NF-kappaB Signaling in Cancer Room: Sea to Sky C Speaker 3 of 4 Daniel Krappmann, Helmholtz Zentrum München, Germany CARMA1-BCL10-MALT1 Signaling in Adaptive Immunity and Lymphoma
Monday, March 14 \| 9:50AM - 11:30AM NF-kappaB Signaling in Cancer Room: Sea to Sky C Speaker 4 of 4 Dinis P. Calado, Francis Crick Institute, UK NF-kappaB Cooperating Events in Mature B Cell-Derived Malignancies
Monday, March 14 \| 9:50AM - 11:30AM Regulation of the Ubiquitin System by Deubiquitylases and Ph osphorylation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 1 of 4 * Philip Cohen, University of Dundee, UK
Monday, March 14 \| 9:50AM - 11:30AM Regulation of the Ubiquitin System by Deubiquitylases and Ph osphorylation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 2 of 4 Titia K. Sixma, Netherlands Cancer Institute, Netherlands Controlling the Isopeptidases: Regulation of Deubiquitination Reactions
Monday, March 14 \| 9:50AM - 11:30AM Regulation of the Ubiquitin System by Deubiquitylases and Ph osphorylation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 3 of 4 Mads Gyrd-Hansen, University of Oxford, UK CYLD limits Lys63- and Met1-linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
Monday, March 14 \| 9:50AM - 11:30AM Regulation of the Ubiquitin System by Deubiquitylases and Ph osphorylation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 4 of 4 Richard J. Youle, NINDS, National Institutes of Health, USA Ubiquitin Signals on Mitochondria Promote Mitophagy via Autophagy Receptors
Monday, March 14 \| 11:30AM - 1:00PM Poster Setup Room: Sea to Sky A
Monday, March 14 \| 11:30AM - 2:30PM On Own for Lunch
Monday, March 14 \| 1:00PM - 10:00PM Poster Viewing Room: Sea to Sky A
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1 Room: Sea to Sky C Speaker 1 of 9 * Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1 Room: Sea to Sky C Speaker 2 of 9 * Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1 Room: Sea to Sky C Speaker 3 of 9 Jian Zhang, Ohio State University, USA Anti-Fungal Innate Immune Response Mediated by C-Type Lectin Receptors Dectin-1 and Dectin-2 Is Regulated by E3 Ubiquitin Ligase Cbl-b
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1 Room: Sea to Sky C Speaker 4 of 9 Claire Tocheny, National Institutes of Health, USA Inflammatory Disease and Immunodeficiency due to Mutation in IkappaBalpha
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1 Room: Sea to Sky C Speaker 5 of 9 Marc Riemann, Leibniz Institute on Aging - Fritz Lipmann Institute, Germany Classical NF-kappaB Signaling via RelA and c-Rel Controls the Development of Medullary Thymic Epithelial Cells
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1 Room: Sea to Sky C Speaker 6 of 9 Firaz Mohideen, Harvard Medical School, USA Systematic Quantitative Proteomics in Response to TNFalpha Signaling Reveals Dynamic Alterations in the Architecture of the Cellular Phospho-proteome
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1 Room: Sea to Sky C Speaker 7 of 9 Isabel Meininger, Helmholtz Zentrum München, Germany Alternative Splicing of MALT1 is Critical for Signaling and Activation of CD4+ T Cells
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1 Room: Sea to Sky C Speaker 8 of 9 Meri Kaustio, FIMM/University of Helsinki, Finland Heterozygous Mutations in NFKB1 cause Immunodeficiency and Autoinflammation
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1 Room: Sea to Sky C Speaker 9 of 9 Mélanie Juilland, University of Lausanne, Switzerland CARMA1- and MyD88-Dependent Activation of Specific AP-1 Complexes is a Hallmark of ABC Diffuse Large B-cell Lymphomas
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Structural Biology and Biochemistry of Ubiquityl ation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 1 of 7 * Rachel Klevit, University of Washington, USA
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Structural Biology and Biochemistry of Ubiquityl ation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 2 of 7 Maria Sunnerhagen, Linkoping University, Sweden Structure of a TRIM21 - UBE2E1 Complex Reveals the Specificity of E2, Ubiquitin and Substrate Recognition by TRIM E3 RINGs
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Structural Biology and Biochemistry of Ubiquityl ation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 3 of 7 Katrin E. Rittinger, Francis Crick Institute, UK Structural and Functional Characterization of TRIM Family E3 Ligases
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Structural Biology and Biochemistry of Ubiquityl ation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 4 of 7 Catherine L. Day, University of Otago, New Zealand Activation of Ubiquitin Transfer by Secondary Ubiquitin–RING Docking
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Structural Biology and Biochemistry of Ubiquityl ation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 5 of 7 Seth F. Harris, Genentech, Inc., USA Structural Insights Into WD-Repeat 48 Activation of Ubiquitin Specific Protease 46
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Structural Biology and Biochemistry of Ubiquityl ation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 6 of 7 Aysegul Ozen, Genentech, Inc., USA Engineering the USP7 Catalytic Domain for Activity
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Structural Biology and Biochemistry of Ubiquityl ation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 7 of 7 Hirotaka Takahashi, Ehime University, Japan Establishment of Deubiquitinating Enzyme Protein Array Based on Wheat Cell-Free System for a Novel Biochemical Tool
Monday, March 14 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Monday, March 14 \| 5:00PM - 7:00PM NF-kappaB Signaling in Immunity Room: Sea to Sky C Speaker 1 of 4 * Manolis Pasparakis, University of Cologne, Germany The Interplay between NEMO, NF-kB and RIPK1 in Cell Death and Inflammation
Monday, March 14 \| 5:00PM - 7:00PM NF-kappaB Signaling in Immunity Room: Sea to Sky C Speaker 2 of 4 Steve D. Gerondakis, Monash University, Australia Is NF-kappaB1 a Tumor Suppressor?
Monday, March 14 \| 5:00PM - 7:00PM NF-kappaB Signaling in Immunity Room: Sea to Sky C Speaker 3 of 4 Xiaoxia Li, Cleveland Clinic Foundation, USA IRAK Regulation of NF-kappaB and MAP Kinase Activation
Monday, March 14 \| 5:00PM - 7:00PM NF-kappaB Signaling in Immunity Room: Sea to Sky C Speaker 4 of 4 * Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA Short Talk: The B-Cell Tumor Promoter Bcl-3 Controls Inflammation-Associated Colon Tumorigenesis
Monday, March 14 \| 5:00PM - 7:00PM Role of Ubiquitylation in Control of Autophagy This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 1 of 5 * Richard J. Youle, NINDS, National Institutes of Health, USA
Monday, March 14 \| 5:00PM - 7:00PM Role of Ubiquitylation in Control of Autophagy This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 2 of 5 James H. Hurley, University of California, Berkeley, USA Mechanistic and Structural Insights into Autophagy Initiation
Monday, March 14 \| 5:00PM - 7:00PM Role of Ubiquitylation in Control of Autophagy This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 3 of 5 J. Wade Harper, Harvard Medical School, USA Ubiquitin Signaling for Mitophagy
Monday, March 14 \| 5:00PM - 7:00PM Role of Ubiquitylation in Control of Autophagy This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 4 of 5 Ivan Dikic, Goethe University Medical School, Germany Ubiquitin Regulation of Selective Autophagy
Monday, March 14 \| 5:00PM - 7:00PM Role of Ubiquitylation in Control of Autophagy This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 5 of 5 Xavier Jacq, MISSION Therapeutics Ltd., UK Short Talk: Inhibitors of USP30 as a Potential Treatment of Parkinson’s disease and Other Mitochondrial Dysfunctions
Monday, March 14 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Sea to Sky A No registration fees are used to fund alcohol served at this function.
Monday, March 14 \| 7:30PM - 10:00PM Poster Session 1 Room: Sea to Sky A
Tuesday, March 15 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky A
Tuesday, March 15 \| 7:30AM - 8:00AM Poster Setup Room: Sea to Sky A
Tuesday, March 15 \| 8:00AM - 5:00PM Poster Viewing Room: Sea to Sky A
Tuesday, March 15 \| 8:00AM - 11:00AM Ubiquitination-Dependent Modulation of NF-kappaB Signaling I (Joint) Room: Sea to Sky B/C Speaker 1 of 6 * Vishva M. Dixit, Genentech, Inc., USA
Tuesday, March 15 \| 8:00AM - 11:00AM Ubiquitination-Dependent Modulation of NF-kappaB Signaling I (Joint) Room: Sea to Sky B/C Speaker 2 of 6 Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA Regulation of Antiviral Innate Immunity by Ubiquitination and Phosphorylation
Tuesday, March 15 \| 8:00AM - 11:00AM Ubiquitination-Dependent Modulation of NF-kappaB Signaling I (Joint) Room: Sea to Sky B/C Speaker 3 of 6 Pascal Meier, Institute of Cancer Research, UK Tipping the Response to TNF in Favor of Death
Tuesday, March 15 \| 8:00AM - 11:00AM Ubiquitination-Dependent Modulation of NF-kappaB Signaling I (Joint) Room: Sea to Sky B/C Speaker 4 of 6 Domagoj Vucic, Genentech, Inc., USA Short Talk: Ubiquitin Ligase Activity of XIAP Regulates NOD2 Mediated Inflammatory Signaling
Tuesday, March 15 \| 8:00AM - 11:00AM Ubiquitination-Dependent Modulation of NF-kappaB Signaling I (Joint) Room: Sea to Sky B/C Speaker 5 of 6 Michaela U. Gack, University of Chicago, USA Regulation of Antiviral Signaling by TRIM E3 Ligases
Tuesday, March 15 \| 8:00AM - 11:00AM Ubiquitination-Dependent Modulation of NF-kappaB Signaling I (Joint) Room: Sea to Sky B/C Speaker 6 of 6 David Komander, Walter and Eliza Hall Institute of Medical Research, Australia Regulating Linear Ubiquitin Chains with OTULIN
Tuesday, March 15 \| 9:40AM - 10:00AM Coffee Break Room: Grand Foyer
Tuesday, March 15 \| 11:00AM - 12:00PM Lunch Room: Sea to Sky A
Tuesday, March 15 \| 12:00PM - 2:30PM Poster Session 2 Room: Sea to Sky A
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Physiology of Ubiquitin-Dependent Signaling This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 1 of 8 * Michael Rape, University of California, Berkeley, USA
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Physiology of Ubiquitin-Dependent Signaling This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 2 of 8 Pieter J. Eichhorn, National University Singapore, Singapore USP15 Regulates SMURF2 Kinetics through C-Lobe Mediated Deubiquitination
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Physiology of Ubiquitin-Dependent Signaling This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 3 of 8 Tohru Ishitani, Medical Institute of Bioregulation, Kyushu University, Japan Ubiquitin-Mediated NF-kappaB Degradation Directs Dorsal-Ventral Patterning in Vertebrate Early Embryo
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Physiology of Ubiquitin-Dependent Signaling This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 4 of 8 Brooke L. Latour, Radboudumc, Netherlands De novo Loss of Function Mutations in the Deubiquitinating Enzyme USP9X cause a Female Specific Syndrome Characterized by Developmental Delay and Distinct Congenital Malformations
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Physiology of Ubiquitin-Dependent Signaling This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 5 of 8 Eli Arama, Weizmann Institute of Science, Israel Spatial Regulation of a CRL3 Complex by a Krebs Cycle Component Restricts Caspase Activation to the Vicinity of the Mitochondria during a Non-apoptotic Cellular Process in Drosophila
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Physiology of Ubiquitin-Dependent Signaling This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 6 of 8 Steven H. Spoel, University of Edinburgh, UK Transcriptional Activation by E3 and E4 Ubiquitin Ligases
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Physiology of Ubiquitin-Dependent Signaling This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 7 of 8 Alexandra Greer, Genentech, Inc., USA Ubiquilin1 is Uniquely Required for Cell Cycle Entry and Proliferation Downstream of B-cell Receptor Signaling
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Physiology of Ubiquitin-Dependent Signaling This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 8 of 8 Satpal Virdee, University of Dundee, UK Engineered E2~Ub Conjugates as Probes of E3 ligase Transthiolation Activity
Tuesday, March 15 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Tuesday, March 15 \| 5:00PM - 7:00PM Transcriptional Regulation in Inflammation Room: Sea to Sky C Speaker 1 of 5 * Michael Karin, University of California, San Diego, USA
Tuesday, March 15 \| 5:00PM - 7:00PM Transcriptional Regulation in Inflammation Room: Sea to Sky C Speaker 2 of 5 Alexander Hoffmann, University of California, Los Angeles, USA Dynamic Control of NFkB
Tuesday, March 15 \| 5:00PM - 7:00PM Transcriptional Regulation in Inflammation Room: Sea to Sky C Speaker 3 of 5 Irina A. Udalova, University of Oxford, UK IRF5 Orchestrated Regulation of Inflammatory Programme in Macrophages
Tuesday, March 15 \| 5:00PM - 7:00PM Transcriptional Regulation in Inflammation Room: Sea to Sky C Speaker 4 of 5 Neal Silverman, University of Massachusetts Medical School, USA Short Talk: Regulation of Drosophila Innate Immune NF-kappaB Signaling by Amyloidal Proteins
Tuesday, March 15 \| 5:00PM - 7:00PM Transcriptional Regulation in Inflammation Room: Sea to Sky C Speaker 5 of 5 Stephen T. Smale, University of California, Los Angeles, USA Global Analysis of Transcriptional Cascades Induced by Inflammatory Stimuli
Tuesday, March 15 \| 5:00PM - 7:00PM Large Machines This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 1 of 5 * Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Tuesday, March 15 \| 5:00PM - 7:00PM Large Machines This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 2 of 5 Andreas Martin, University of California, Berkeley, USA 26S Proteasome Assembly and Conformational Changes Control Substrate Deubiquitination by Rpn11
Tuesday, March 15 \| 5:00PM - 7:00PM Large Machines This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 3 of 5 Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research, Switzerland Regulation of Cullin-RING-ligase activity by CSN
Tuesday, March 15 \| 5:00PM - 7:00PM Large Machines This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 4 of 5 Raymond J. Deshaies, Amgen, Inc., USA Regulation of CRL Assembly: The Adaptive Exchange Hypothesis
Tuesday, March 15 \| 5:00PM - 7:00PM Large Machines This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 5 of 5 Jessica A. Gasser, Broad Institute of MIT and Harvard, USA Short Talk: Genome-Wide CRISPR-Cas9 Screen Reveals Genes Required for the Effect of Lenalidomide on the CRL4-CRBN Ubiquitin Ligase
Tuesday, March 15 \| 7:00PM - 7:00PM On Own for Dinner
Wednesday, March 16 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky A
Wednesday, March 16 \| 8:00AM - 11:00AM NLR Signaling to NF-kappaB and IRF Room: Sea to Sky C Speaker 1 of 6 * Rudi Beyaert, Ghent University - VIB, Belgium
Wednesday, March 16 \| 8:00AM - 11:00AM NLR Signaling to NF-kappaB and IRF Room: Sea to Sky C Speaker 2 of 6 Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA NLRs as Regulators of NFkappaB and MAPK Signaling
Wednesday, March 16 \| 8:00AM - 11:00AM NLR Signaling to NF-kappaB and IRF Room: Sea to Sky C Speaker 3 of 6 Feng Shao, National Institute of Biological Sciences, China Pyroptosis in Anti-Bacterial Immunity: Sensing and Execution
Wednesday, March 16 \| 8:00AM - 11:00AM NLR Signaling to NF-kappaB and IRF Room: Sea to Sky C Speaker 4 of 6 Benedict Seddon, University College London, UK Short Talk: TNF Activation of NF-kappaB is Essential for Development of Single Positive Thymocytes
Wednesday, March 16 \| 8:00AM - 11:00AM NLR Signaling to NF-kappaB and IRF Room: Sea to Sky C Speaker 5 of 6 Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA Regulators of Inflammatory Responses
Wednesday, March 16 \| 8:00AM - 11:00AM NLR Signaling to NF-kappaB and IRF Room: Sea to Sky C Speaker 6 of 6 Vishva M. Dixit, Genentech, Inc., USA RIPK3: Role of the Kinase Activity in Necroptosis
Wednesday, March 16 \| 8:00AM - 11:00AM Ubiquitylation and Human Disease This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 1 of 6 * Ingrid E. Wertz, Genentech, Inc., USA
Wednesday, March 16 \| 8:00AM - 11:00AM Ubiquitylation and Human Disease This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 2 of 6 Michael Rape, University of California, Berkeley, USA Ubiquitin-Dependent Regulation of Craniofacial Development
Wednesday, March 16 \| 8:00AM - 11:00AM Ubiquitylation and Human Disease This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 3 of 6 Dario Alessi, University of Dundee, UK Control of Blood Pressure
Wednesday, March 16 \| 8:00AM - 11:00AM Ubiquitylation and Human Disease This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 4 of 6 Noam Zelcer, Academic Medical Center, University of Amsterdam, Netherlands Short Talk: USP2 Regulates the LDLR Pathway through Deubiquitylation of the E3-ubiquitin Ligase IDOL
Wednesday, March 16 \| 8:00AM - 11:00AM Ubiquitylation and Human Disease This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 5 of 6 Heran Darwin, New York University School of Medicine, USA Proteasomal Regulation of Mycobacterium tuberculosis Pathogenesis
Wednesday, March 16 \| 8:00AM - 11:00AM Ubiquitylation and Human Disease This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 6 of 6 Jeffery S. Cox, University of California, Berkeley, USA Discrimination of Pathogens from Non-Pathogens by Innate Immune Cells
Wednesday, March 16 \| 9:40AM - 10:00AM Coffee Break Room: Grand Foyer
Wednesday, March 16 \| 11:00AM - 1:00PM Poster Setup Room: Sea to Sky A
Wednesday, March 16 \| 11:00AM - 2:30PM On Own for Lunch
Wednesday, March 16 \| 1:00PM - 10:00PM Poster Viewing Room: Sea to Sky A
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 2 Room: Sea to Sky C Speaker 1 of 9 * Steve D. Gerondakis, Monash University, Australia
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 2 Room: Sea to Sky C Speaker 2 of 9 * Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 2 Room: Sea to Sky C Speaker 3 of 9 Simon Rousseau, McGill University, Canada Differential Contributions of theTPL2-MKK1/MKK2-ERK1/ERK2 and NFkB Pathways to Oncogenic Transformation in Lymphoid Neoplasms
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 2 Room: Sea to Sky C Speaker 4 of 9 Nadine Mikuda, Max-Delbrück-Center for Molecular Medicine, MDC, Germany The IkappaB Kinase Complex is a Universal Regulator of mRNA Stability in Response to Stress
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 2 Room: Sea to Sky C Speaker 5 of 9 Marina Kolesnichenko, Max Delbrueck Center for Molecular Medicine, Germany Senescence Associated NFkappaB Inflammatory Response is Driven by an mRNA Destabilization Mechanism
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 2 Room: Sea to Sky C Speaker 6 of 9 Benjamin E. Gewurz, Brigham and Women's Hospital, Harvard Medical School, USA The NF-kB Genomic Landscape in CD40-Stimulated Primary Human B-cells
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 2 Room: Sea to Sky C Speaker 7 of 9 Anetta Svitorka Härtlova, University of Gothenburg, Sweden Scavenger Receptor MSR-JNK Pathway Control Phenotypic Switch of Alternatively Activated Macrophages
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 2 Room: Sea to Sky C Speaker 8 of 9 Ricardo Antonia, University of North Carolina, USA IKK Promotes AMPK Activity by Phosphorylating Threonine 172 in Response to IL-1beta
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 2 Room: Sea to Sky C Speaker 9 of 9 Ruaidhri Carmody, University of Glasgow, UK Control of MAP Kinase and NF-kappaB Pathways by the Nuclear IkappaB-like factor Bcl-3
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 3: The Interplay between Ubiquitylation and Phospho rylation in Cell Regulation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 1 of 7 * David Komander, Walter and Eliza Hall Institute of Medical Research, Australia
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 3: The Interplay between Ubiquitylation and Phospho rylation in Cell Regulation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 2 of 7 Maria Isabel Acosta Lopez, University of Nice Sophia Antipolis, France New Regulatory Mechanism and Cellular Function of the Tumor Suppressor HACE1
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 3: The Interplay between Ubiquitylation and Phospho rylation in Cell Regulation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 3 of 7 Niall Dillon, Medical Research Council, UK Phosphorylation of the E2 Ubiquitin Conjugating Enzyme UBE2D3 Regulates Polycomb-Mediated Gene Priming in Pluripotent ES Cells
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 3: The Interplay between Ubiquitylation and Phospho rylation in Cell Regulation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 4 of 7 Jeffrey R. Johnson, University of California, San Francisco, USA Ubiquitin Remnant Profiling Identifies a Novel Substrate of HIV-Mediated Ubiquitination and Degradation
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 3: The Interplay between Ubiquitylation and Phospho rylation in Cell Regulation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 5 of 7 R. Jeremy Nichols, Parkinson's Institute, USA The LRRK2 Phosphorylation-Ubiquitination Cycle
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 3: The Interplay between Ubiquitylation and Phospho rylation in Cell Regulation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 6 of 7 Camillo Palmieri, Università Magna Grecia of Catanzaro, Italy Regulation of IBtk-alpha Activity by mTOR-Mediated Phosphorylation
Wednesday, March 16 \| 2:30PM - 4:30PM Workshop 3: The Interplay between Ubiquitylation and Phospho rylation in Cell Regulation This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 7 of 7 Nicolas Bidère, INSERM, France The Paracaspase MALT1 Cleaves the LUBAC Subunit HOIL1 during Antigen Receptor Signaling
Wednesday, March 16 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Wednesday, March 16 \| 5:00PM - 7:00PM MAP Kinase Signaling in Inflammation Room: Sea to Sky C Speaker 1 of 5 * Xiaoxia Li, Cleveland Clinic Foundation, USA
Wednesday, March 16 \| 5:00PM - 7:00PM MAP Kinase Signaling in Inflammation Room: Sea to Sky C Speaker 2 of 5 Steven C. Ley, Francis Crick Institute, UK Regulation of Inflammation by TPL-2 MAP 3-kinase
Wednesday, March 16 \| 5:00PM - 7:00PM MAP Kinase Signaling in Inflammation Room: Sea to Sky C Speaker 3 of 5 Ana Cuenda, Spanish National Biotechnology Centre, Spain Regulation of Inflammation by p38gamma/delta
Wednesday, March 16 \| 5:00PM - 7:00PM MAP Kinase Signaling in Inflammation Room: Sea to Sky C Speaker 4 of 5 Mathieu JM Bertrand, VIB / Ghent University, Belgium Short Talk: NF-kB-Independent Role of IKKa/IKKb in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling
Wednesday, March 16 \| 5:00PM - 7:00PM MAP Kinase Signaling in Inflammation Room: Sea to Sky C Speaker 5 of 5 Roger J. Davis, HHMI/University of Massachusetts Medical School, USA Role of JNK in Metabolic Stress Signaling
Wednesday, March 16 \| 5:00PM - 7:00PM Structural Analysis of E3 Ligases and DUBs This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 1 of 5 * Titia K. Sixma, Netherlands Cancer Institute, Netherlands
Wednesday, March 16 \| 5:00PM - 7:00PM Structural Analysis of E3 Ligases and DUBs This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 2 of 5 Rachel Klevit, University of Washington, USA Mechanistic Strategies of RING-Between-RING (RBR) E3 Ligases
Wednesday, March 16 \| 5:00PM - 7:00PM Structural Analysis of E3 Ligases and DUBs This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 3 of 5 Bernhard Clemens Lechtenberg, Sanford Burnham Prebys Medical Discovery Institute, USA Short Talk: Structure of the HOIP-RBR/E2~ubiquitin Transfer Complex Reveals a Universal Mechanism for RBR E3 Ubiquitin Ligases
Wednesday, March 16 \| 5:00PM - 7:00PM Structural Analysis of E3 Ligases and DUBs This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 4 of 5 Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany Cullin-RING E3 Ligation Mechanisms
Wednesday, March 16 \| 5:00PM - 7:00PM Structural Analysis of E3 Ligases and DUBs This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 5 of 5 Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA E3 Ligases: Activities and Specificity
Wednesday, March 16 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Sea to Sky A No registration fees are used to fund alcohol served at this function.
Wednesday, March 16 \| 7:30PM - 10:00PM Poster Session 3 Room: Sea to Sky A
Thursday, March 17 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky A
Thursday, March 17 \| 8:00AM - 11:00AM Therapeutic Targeting of Inflammation Room: Sea to Sky C Speaker 1 of 5 * Daniel Krappmann, Helmholtz Zentrum München, Germany
Thursday, March 17 \| 8:00AM - 11:00AM Therapeutic Targeting of Inflammation Room: Sea to Sky C Speaker 2 of 5 Stefan Knapp, University of Oxford, UK Targeting Bromodomains in Inflammation
Thursday, March 17 \| 8:00AM - 11:00AM Therapeutic Targeting of Inflammation Room: Sea to Sky C Speaker 3 of 5 Vanessa C. Taylor, Rigel Inc., USA R191, A Small Molecule IRAK1/4 Kinase Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases
Thursday, March 17 \| 8:00AM - 11:00AM Therapeutic Targeting of Inflammation Room: Sea to Sky C Speaker 4 of 5 Eric P. Hanson, National Institutes of Health, USA Short Talk: Recruitment of A20 by the C-Terminal Domain of NEMO Suppresses NF-kappaB Activation and Autoinflammatory Disease
Thursday, March 17 \| 8:00AM - 11:00AM Therapeutic Targeting of Inflammation Room: Sea to Sky C Speaker 5 of 5 Vikram R. Rao, Pfizer, USA The Role of IRAK4 in NFkB and MAPK Signaling: Implications for Drug Development
Thursday, March 17 \| 8:00AM - 11:00AM Small Molecules and Therapeutics This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 1 of 6 * Raymond J. Deshaies, Amgen, Inc., USA
Thursday, March 17 \| 8:00AM - 11:00AM Small Molecules and Therapeutics This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 2 of 6 Zhihao Zhuang, University of Delaware, USA Targeting Deubiquitinase in DNA Damage Response for Anticancer Therapy
Thursday, March 17 \| 8:00AM - 11:00AM Small Molecules and Therapeutics This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 3 of 6 Alessio Ciulli, University of Dundee, School of Life Sciences, UK Short Talk: Small Molecules for the VHL Cul2 E3 Ligase: VHL-HIF Inhibitors and Proteolysis Targeting Chimeras (PROTACs)
Thursday, March 17 \| 8:00AM - 11:00AM Small Molecules and Therapeutics This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 4 of 6 Georg Petzold, Friedrich Miescher Institute for Biomedical Research, Switzerland Short Talk: Structural Basis of Lenalidomide-induced CK1alpha Degradation by the CRL4-CRBN Ubiquitin Ligase
Thursday, March 17 \| 8:00AM - 11:00AM Small Molecules and Therapeutics This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 5 of 6 Ingrid E. Wertz, Genentech, Inc., USA Phosphorylation and Linear Ubiquitin Direct A20 Inhibition of Inflammation
Thursday, March 17 \| 8:00AM - 11:00AM Small Molecules and Therapeutics This session is from Ubiquitin Signaling Room: Sea to Sky B Speaker 6 of 6 Frank Sicheri, Lunenfeld-Tanenbaum Research Institute, Canada The Structural basis for Poly-Ubiquitin Chain Cleavage and Regulation: Lessons Learned from BRCC36
Thursday, March 17 \| 9:20AM - 9:40AM Coffee Break Room: Grand Foyer
Thursday, March 17 \| 11:00AM - 5:00PM On Own for Lunch
Thursday, March 17 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Thursday, March 17 \| 5:00PM - 7:15PM Ubiquitin-Dependent Modulation of NF-kappaB Signaling II (Jo int) Room: Sea to Sky B/C Speaker 1 of 5 * Ivan Dikic, Goethe University Medical School, Germany
Thursday, March 17 \| 5:00PM - 7:15PM Ubiquitin-Dependent Modulation of NF-kappaB Signaling II (Jo int) Room: Sea to Sky B/C Speaker 2 of 5 Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA Epigenetic Regulation of NF-kB Function and Inflammation by Ubiquitination
Thursday, March 17 \| 5:00PM - 7:15PM Ubiquitin-Dependent Modulation of NF-kappaB Signaling II (Jo int) Room: Sea to Sky B/C Speaker 3 of 5 Shigeki Miyamoto, University of Wisconsin, Madison, USA Investigation of NF-kappaB Signaling Induced by Genotoxic Agents and Potentially Novel Activators
Thursday, March 17 \| 5:00PM - 7:15PM Ubiquitin-Dependent Modulation of NF-kappaB Signaling II (Jo int) Room: Sea to Sky B/C Speaker 4 of 5 Rudi Beyaert, Ghent University - VIB, Belgium The Dual Faces of Paracaspase MALT1 in Inflammation and Immunity
Thursday, March 17 \| 5:00PM - 7:15PM Ubiquitin-Dependent Modulation of NF-kappaB Signaling II (Jo int) Room: Sea to Sky B/C Speaker 5 of 5 Philip Cohen, University of Dundee, UK Re-Writing the Interleukin-1 Signaling Network
Thursday, March 17 \| 7:15PM - 7:30PM Meeting Wrap-Up: Outcomes and Future Directions (Joint) Room: Sea to Sky B/C Speaker 1 of 1 Philip Cohen, University of Dundee, UK
Thursday, March 17 \| 7:30PM - 8:30PM Social Hour with Lite Bites Room: Sea to Sky A No registration fees are used to fund alcohol served at this function.
Thursday, March 17 \| 8:00PM - 11:00PM Entertainment Room: Sea to Sky A Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, March 17 \| 8:00PM - 11:00PM Cash Bar Room: Sea to Sky A
Friday, March 18 \| 10:25AM - 10:25AM Departure *Session Chair.