Web Desc
Islet Biology: From Cell Birth to Death
joint with Stem Cells and Regeneration in the Digestive Organs
Organizer(s): Klaus H. Kaestner, Christopher J. Rhodes and Yuval Dor
Date: March 13 - 17, 2016
Location: Keystone Resort, Keystone, CO, USA
Sponsored by MedImmune and Novo Nordisk A/S
For important information on the coronavirus, please click here
Summary of Meeting:
The islets of Langerhans, endocrine micro-organs within the pancreas, are at the center of multiple metabolic diseases, from hyperinsulinism to diabetes. Islets elaborate the key hormones, glucagon and insulin that control glucose homeostasis, and their dysfunction in diabetes causes severe morbidity in more than 300 million people worldwide, with associated healthcare costs in the hundreds of billions of dollars annually. This Keystone Symposia meeting covers innovative research in all aspects of islet biology, from the developmental origin of endocrine cell types in fetal life, to beta-cell failure in type 2 diabetes. The specific goals of the conference are to: 1) Present unpublished data that cover critical knowledge gaps in the field; 2) Evaluate the state of the art of novel therapeutics for diabetes, including cell replacement therapies; and 3) Provide training for young investigators in the field. New international collaborations fostered by this conference should accelerate progress in this important field of biomedical research.
Scholarship Deadline: November 12 2015
Discounted Abstract Deadline: November 12 2015
Abstract Deadline: December 15 2015
Discounted Registration Deadline: January 14 2016
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
MedImmuneNovo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
Mercodia, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

MedImmune

Regeneron Pharmaceuticals, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK108622-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 13 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, March 13 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 14 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Monday, March 14 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Grays/Longs Peak

Speaker 1 of 3
* Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA

Monday, March 14 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Grays/Longs Peak

Speaker 2 of 3
* Linheng Li, Stowers Institute for Medical Research, USA

Monday, March 14 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Grays/Longs Peak

Speaker 3 of 3
Hiromitsu Nakauchi, Stanford University, USA
Interspecific Blastocyst Complementation: Can Patient-Specific Islets of Langerhans Be Generated in Pigs?

Monday, March 14 | 9:00AM - 9:30AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 14 | 9:30AM - 11:45AM
Developmental and Regenerative Biology of the Endocrine Panc
reas

Room: Longs Peak

Speaker 1 of 6
* Lori Sussel, University of Colorado Anschutz Medical Campus, USA

Monday, March 14 | 9:30AM - 11:45AM
Developmental and Regenerative Biology of the Endocrine Panc
reas

Room: Longs Peak

Speaker 2 of 6
Anne Grapin-Botton, University of Copenhagen, Denmark
Progenitor Heterogeneity as a Driver of Pancreas Development

Monday, March 14 | 9:30AM - 11:45AM
Developmental and Regenerative Biology of the Endocrine Panc
reas

Room: Longs Peak

Speaker 3 of 6
Chris Wright, Vanderbilt University Medical Center, USA
Intra-Islet Endocrine-Cell Communication and the Control of Beta-Cell Number and Replication State

Monday, March 14 | 9:30AM - 11:45AM
Developmental and Regenerative Biology of the Endocrine Panc
reas

Room: Longs Peak

Speaker 4 of 6
Seung K. Kim, Stanford University, USA
Signaling Regulation of Islet Morphogenesis

Monday, March 14 | 9:30AM - 11:45AM
Developmental and Regenerative Biology of the Endocrine Panc
reas

Room: Longs Peak

Speaker 5 of 6
Caitlin Braitsch, University of Texas Southwestern Medical Center, USA
Short Talk: Hippo-Warts Pathway Regulation of Pancreatic Epithelial Architecture and Progenitor Cell Fate

Monday, March 14 | 9:30AM - 11:45AM
Developmental and Regenerative Biology of the Endocrine Panc
reas

Room: Longs Peak

Speaker 6 of 6
Alireza Rezania, CRISPR Therapeutics, USA
Short Talk: In vitro Generation of Insulin-producing Cells with Insulin Secretion Dynamics and Mitochondrial Metabolism Similar to Adult Human Islets

Monday, March 14 | 9:30AM - 11:30AM
GI Lineages from Pluripotent Stem Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 1 of 5
* Stephen A. Duncan, Medical University of South Carolina, USA


Monday, March 14 | 9:30AM - 11:30AM
GI Lineages from Pluripotent Stem Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 2 of 5
Gordon M. Keller, University Health Network, MaRS Centre, Canada
Patterning Human Pluripotent Stem Cell-Derived Endoderm


Monday, March 14 | 9:30AM - 11:30AM
GI Lineages from Pluripotent Stem Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 3 of 5
Paul Gadue, Children's Hospital of Philadelphia, USA
GATA6 Regulation of Endoderm and Pancreatic Development from Human Pluripotent Stem Cells


Monday, March 14 | 9:30AM - 11:30AM
GI Lineages from Pluripotent Stem Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 4 of 5
James M. Wells, Cincinnati Children's Hospital Research Foundation, USA
Human Pluripotent Stem Cell-Derived Tissues as New Models to Study Development and Disease of the Digestive Tract


Monday, March 14 | 9:30AM - 11:30AM
GI Lineages from Pluripotent Stem Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 5 of 5
Alexander Kleger, Ulm University, Germany
Short Talk: Human Pluripotent Stem Cell-Derived Pancreatic Organoids to Study Cystic Fibrosis in a Dish


Monday, March 14 | 11:45AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Monday, March 14 | 11:45AM - 2:30PM
On Own for Lunch


Monday, March 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Pancreatic Islet Cell Development, Growth and Re
generation
Room: Longs Peak

Speaker 1 of 9
* Doris A. Stoffers, Perelman School of Medicine, University of Pennsylvania, USA

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Pancreatic Islet Cell Development, Growth and Re
generation
Room: Longs Peak

Speaker 2 of 9
Yunus Alpagu, IMB-ASTAR, Singapore
Modelling Mitchell-Riley Syndrome in vitro using iPS Cells Derived from a RFX6 Mutant Patient

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Pancreatic Islet Cell Development, Growth and Re
generation
Room: Longs Peak

Speaker 3 of 9
Caitlin Collin, University of Copenhagen, Denmark
The Function of Notch Ligands in Pancreas Development

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Pancreatic Islet Cell Development, Growth and Re
generation
Room: Longs Peak

Speaker 4 of 9
Nidheesh Dadheech, University of Alberta, Canada
GLP-1 Induces Neurog3 Re-expression and Beta-Cell Neogenesis in Adult Mice

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Pancreatic Islet Cell Development, Growth and Re
generation
Room: Longs Peak

Speaker 5 of 9
Benjamin Neal Ediger, University of Pennsylvania, USA
Ldb1 Maintains the Terminally Differentiated State of Pancreatic Beta-cells through a Functional Interaction with Isl-1

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Pancreatic Islet Cell Development, Growth and Re
generation
Room: Longs Peak

Speaker 6 of 9
Katie L. Sinagoga, Cincinnati Children's Hospital Medical Center, USA
mTOR Regulates Postnatal Morphogenesis, Maturation, and Function of Murine Islets

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Pancreatic Islet Cell Development, Growth and Re
generation
Room: Longs Peak

Speaker 7 of 9
Francesca M. Spagnoli, Max Delbrück Center for Molecular Medicine, Germany
Axon Guidance Signaling Controls Pancreatic Cell Identity

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Pancreatic Islet Cell Development, Growth and Re
generation
Room: Longs Peak

Speaker 8 of 9
Amita Tiyaboonchai, University of Pennsylvania, USA
GATA6 in Human Endoderm and Pancreatic Development from Human Pluripotent Stem Cells

Monday, March 14 | 2:30PM - 4:30PM
Workshop 1: Pancreatic Islet Cell Development, Growth and Re
generation
Room: Longs Peak

Speaker 9 of 9
Pei Wang, University of Texas Health Science Center at San Antonio, USA
Investigating the Role of the Hippo Signaling Pathway in Pancreatic Endocrine Cell Development and Beta Cell Proliferation

Monday, March 14 | 2:30PM - 4:30PM
Workshop and Panel Discussion 1: Tissue Engineering
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 1 of 6
* Mo Ebrahimkhani, Arizona State University, USA
Engineering Self-Organization of Human Pluripotent Stem Cells to a Fetal Liver-Like Tissue


Monday, March 14 | 2:30PM - 4:30PM
Workshop and Panel Discussion 1: Tissue Engineering
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 2 of 6
Bruce M. Wang, Stanford University, USA
Self-Renewing Diploid Axin2+ Cells Fuel Homeostatic Renewal of the Liver


Monday, March 14 | 2:30PM - 4:30PM
Workshop and Panel Discussion 1: Tissue Engineering
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 3 of 6
Joseph J. Lancman, Sanford Burnham Presbys Medical Discovery Institute, USA
Induced in vivo Cell Reprogramming of Muscle into Endoderm Lineages


Monday, March 14 | 2:30PM - 4:30PM
Workshop and Panel Discussion 1: Tissue Engineering
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 4 of 6
Kay Wiebrands, Hubrecht Institute, Netherlands
Single-Cell RNA Sequencing Reveals Divergence of Lgr5+ Stem Cells during Development of the Gastrointestinal Tract


Monday, March 14 | 2:30PM - 4:30PM
Workshop and Panel Discussion 1: Tissue Engineering
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 5 of 6
Alan C. Mullen, Harvard Medical School, USA
DIGIT is a Conserved Long Noncoding RNA that Regulates Goosecoid Expression to Control Endoderm Differentiation of Human Embryonic Stem Cells


Monday, March 14 | 2:30PM - 4:30PM
Workshop and Panel Discussion 1: Tissue Engineering
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 6 of 6
* Jan Jensen, Lerner Research Institute, USA
Understanding Multi-Lineage Differentiation of Endodermal Progenitor Cells using a Systems Developmental Biology Approach


Monday, March 14 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 14 | 5:00PM - 7:00PM
Controlling Beta-Cell Function
Room: Longs Peak

Speaker 1 of 4
* Alvin C. Powers, Vanderbilt University School of Medicine, USA

Monday, March 14 | 5:00PM - 7:00PM
Controlling Beta-Cell Function
Room: Longs Peak

Speaker 2 of 4
Doris A. Stoffers, Perelman School of Medicine, University of Pennsylvania, USA
Mining the Pdx1 Cistrome for Novel Insights into Diabetes

Monday, March 14 | 5:00PM - 7:00PM
Controlling Beta-Cell Function
Room: Longs Peak

Speaker 3 of 4
Christopher J. Rhodes, AstraZeneca, USA
CNS Control of Pancreatic Islet-Cell Function

Monday, March 14 | 5:00PM - 7:00PM
Controlling Beta-Cell Function
Room: Longs Peak

Speaker 4 of 4
Cristina M. Rondinone, Cellarity Inc., USA
Novel Direct and Indirect Ways to Improve Beta Cell Health

Monday, March 14 | 5:00PM - 7:00PM
Disease Modeling
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 1 of 5
* Gordon M. Keller, University Health Network, MaRS Centre, Canada


Monday, March 14 | 5:00PM - 7:00PM
Disease Modeling
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 2 of 5
Frederic J. de Sauvage, Genentech, Inc., USA
Targeting Intestinal Stem Cells in Cancer


Monday, March 14 | 5:00PM - 7:00PM
Disease Modeling
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 3 of 5
Stephen A. Duncan, Medical University of South Carolina, USA
Disease Modeling with ESC/iPSCs-Derived Hepatocyte-Like Cells


Monday, March 14 | 5:00PM - 7:00PM
Disease Modeling
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 4 of 5
Holger Willenbring, University of California, San Francisco, USA
Liver Cell Therapy with Hepatocytes Derived from Pluripotent Stem Cells


Monday, March 14 | 5:00PM - 7:00PM
Disease Modeling
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 5 of 5
Tobias Cantz, Hannover Medical School, Germany
Short Talk: Patient-Specific iPS Cell-Based Hepatic Cells Allow Modeling of Transthyretin-Related Familial Amyloid Polyneuropathy


Monday, March 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Monday, March 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Red Cloud/Shavano/Torreys


Tuesday, March 15 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Tuesday, March 15 | 8:00AM - 11:15AM
Beta-Cell Growth and Proliferation
Room: Longs Peak

Speaker 1 of 7
* Andrew F. Stewart, Mount Sinai School of Medicine, USA

Tuesday, March 15 | 8:00AM - 11:15AM
Beta-Cell Growth and Proliferation
Room: Longs Peak

Speaker 2 of 7
Yuval Dor, Hebrew University-Hadassah Medical School, Israel
The Genetic Program of Replicating beta Cells

Tuesday, March 15 | 8:00AM - 11:15AM
Beta-Cell Growth and Proliferation
Room: Longs Peak

Speaker 3 of 7
Heiko Lickert, Institute of Diabetes and Regeneration, Germany
Identification of Proliferative and Mature B-cells in the Islet of Langerhans

Tuesday, March 15 | 8:00AM - 11:15AM
Beta-Cell Growth and Proliferation
Room: Longs Peak

Speaker 4 of 7
Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
The Epigenome during Beta-Cell Maturation

Tuesday, March 15 | 8:00AM - 11:15AM
Beta-Cell Growth and Proliferation
Room: Longs Peak

Speaker 5 of 7
Jorge Ferrer, Imperial College London, UK
Long Noncoding RNAs in Beta-Cells

Tuesday, March 15 | 8:00AM - 11:15AM
Beta-Cell Growth and Proliferation
Room: Longs Peak

Speaker 6 of 7
Justin P. Annes, Stanford University, USA
Short Talk: Multi-ligand Targeting of DYRK1A/B and Casein Kinase1gamma2 Promotes beta-cell Replication

Tuesday, March 15 | 8:00AM - 11:15AM
Beta-Cell Growth and Proliferation
Room: Longs Peak

Speaker 7 of 7
Bethany A. Carboneau, Vanderbilt University, USA
Short Talk: Regulation of Beta-Cell Mass Expansion by Prostaglandin E2 Signaling

Tuesday, March 15 | 8:00AM - 11:00AM
Identity and Function of GI Stem and Progenitor Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 1 of 6
* Hans C. Clevers, Hubrecht Institute, Netherlands


Tuesday, March 15 | 8:00AM - 11:00AM
Identity and Function of GI Stem and Progenitor Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 2 of 6
Frédéric Lemaigre, de Duve Institute and Université Catholique de Louvain, Belgium
Dynamics of Hepatic Cell Differentiation Depend on microRNA-Dependent Regulatory Motifs


Tuesday, March 15 | 8:00AM - 11:00AM
Identity and Function of GI Stem and Progenitor Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 3 of 6
Stuart J. Forbes, University of Edinburgh, UK
The Role of Hepatic Progenitor Cells in Liver Regeneration


Tuesday, March 15 | 8:00AM - 11:00AM
Identity and Function of GI Stem and Progenitor Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 4 of 6
Timothy C. Wang, Columbia University, USA
Gastric Stem Cells and Their Niches


Tuesday, March 15 | 8:00AM - 11:00AM
Identity and Function of GI Stem and Progenitor Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 5 of 6
Linheng Li, Stowers Institute for Medical Research, USA
Characterization of Drug-resistant Quiescent Stem Cells in Intestine


Tuesday, March 15 | 8:00AM - 11:00AM
Identity and Function of GI Stem and Progenitor Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 6 of 6
Nicholas R. Smith, Oregon Health & Science University, USA
Short Talk: Bmi1-Expressing Intestinal Stem Cells Drive Emergency Re-Epithelialization


Tuesday, March 15 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, March 15 | 11:15AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Tuesday, March 15 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, March 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pancreatic Beta-Cell Death and Survival
Room: Longs Peak

Speaker 1 of 9
* Guy A. Rutter, Imperial College London, UK

Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pancreatic Beta-Cell Death and Survival
Room: Longs Peak

Speaker 2 of 9
Michal Aharoni-Simon, University of British Columbia, Canada
Anti-Apoptotic Bcl-2 Regulates Reactive Oxygen Species Signaling and a Redox-Sensitive Mitochondrial Proton Leak in Mouse Pancreatic beta-Cells

Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pancreatic Beta-Cell Death and Survival
Room: Longs Peak

Speaker 3 of 9
Lukas Adrian Berchtold, University of Copenhagen, Denmark
Pannexin-2 is an Anti-Apoptotic Protein in Pancreatic beta-Cells

Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pancreatic Beta-Cell Death and Survival
Room: Longs Peak

Speaker 4 of 9
Anne Close, University of Alberta, Canada
The Nuclear Receptor Nor1/Nr4a3 Mediates Cytokines-induced beta-cell Apoptosis and Regulates beta-cell Mass

Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pancreatic Beta-Cell Death and Survival
Room: Longs Peak

Speaker 5 of 9
Yong Kyung Kim, University of Colorado, Anshcutz Medical Campus, USA
Disruption of Mitochondrial Crif1 (CR6-interacting factor-1) in Mouse beta Cells Leads to Diabetes with Progressive beta Cell Failure

Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pancreatic Beta-Cell Death and Survival
Room: Longs Peak

Speaker 6 of 9
Amelia K. Linnemann, University of Wisconsin-Madison, USA
Interleukin-6 Stimulates Autophagy in Pancreatic beta-cells and Protects against Apoptosis

Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pancreatic Beta-Cell Death and Survival
Room: Longs Peak

Speaker 7 of 9
Michelle E. Kimple, University of Wisconsin, Madison, USA
G-protein-mediated Mechanisms Linking Beta-cell Death, Dysfunction, and Decompensation in Diabetes

Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pancreatic Beta-Cell Death and Survival
Room: Longs Peak

Speaker 8 of 9
Jason M. Tonne, Mayo Clinic, USA
Nestin-positive Pericytes Facilitate beta-cell-protection through Prevention of Excessive beta-cell-targeted Immune Reactions and Promotion of beta-cell Regeneration in Insulitis

Tuesday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pancreatic Beta-Cell Death and Survival
Room: Longs Peak

Speaker 9 of 9
Brett S. Peterson, Duke University, USA
Delayed Apoptosis Allows Islet beta-cells to Implement an Autophagic Mechanism to Promote Cell Survival

Tuesday, March 15 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, March 15 | 5:00PM - 7:00PM
Other Islet Cell Types: Major Contributor to Glucose Homeost
asis and Health?

Room: Longs Peak

Speaker 1 of 5
* Nils Billestrup, University of Copenhagen, Denmark

Tuesday, March 15 | 5:00PM - 7:00PM
Other Islet Cell Types: Major Contributor to Glucose Homeost
asis and Health?

Room: Longs Peak

Speaker 2 of 5
Alvin C. Powers, Vanderbilt University School of Medicine, USA
Interactions of Endothelial Cells, Macrophages, and Islet Cells

Tuesday, March 15 | 5:00PM - 7:00PM
Other Islet Cell Types: Major Contributor to Glucose Homeost
asis and Health?

Room: Longs Peak

Speaker 3 of 5
Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
ATP-Regulated Potassium Channels in the Regulation of Glucagon Secretion

Tuesday, March 15 | 5:00PM - 7:00PM
Other Islet Cell Types: Major Contributor to Glucose Homeost
asis and Health?

Room: Longs Peak

Speaker 4 of 5
Per-Olof Berggren, Karolinska Institutet, Sweden
Insight Into Pancreatic Islet Cell Physiology/Pathology

Tuesday, March 15 | 5:00PM - 7:00PM
Other Islet Cell Types: Major Contributor to Glucose Homeost
asis and Health?

Room: Longs Peak

Speaker 5 of 5
Guy A. Rutter, Imperial College London, UK
Short Talk: Deletion of the Type 2 Diabetes-associated Gene StarD10 in Mice Impairs Insulin Secretion and Action

Tuesday, March 15 | 5:00PM - 7:00PM
Programmed or Reprogrammed Regeneration
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 1 of 5
* Holger Willenbring, University of California, San Francisco, USA


Tuesday, March 15 | 5:00PM - 7:00PM
Programmed or Reprogrammed Regeneration
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 2 of 5
Lijian Hui, Shanghai Institutes of Biological Sciences, China
Direct Reprogramming of Human Fibroblasts to Functional Hepatocyte-Like Cells


Tuesday, March 15 | 5:00PM - 7:00PM
Programmed or Reprogrammed Regeneration
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 3 of 5
Louise Laurent, University of California, San Diego, USA
Using Single-Cell Transcriptomics to Discover Cellular Reprogramming Factors for Autologous Cell Replacement Therapy for Type 1 Diabetes


Tuesday, March 15 | 5:00PM - 7:00PM
Programmed or Reprogrammed Regeneration
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 4 of 5
Markus Grompe, Oregon Health & Science University, USA
Tissue Regeneration in Liver: Plasticity or Stem Cells?


Tuesday, March 15 | 5:00PM - 7:00PM
Programmed or Reprogrammed Regeneration
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 5 of 5
Claude Gérard, Université Catholique de Louvain, Belgium
Short Talk: A Mathematical Model for the Transcription Factor Network Driving Hepatocyte Differentiation


Tuesday, March 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Tuesday, March 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Red Cloud/Shavano/Torreys


Wednesday, March 16 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Wednesday, March 16 | 8:00AM - 11:00AM
Adult Pancreatic Stem Cells (Joint)
Room: Longs/Grays Peak

Speaker 1 of 7
* Catherine Lee May, University of Pennsylvania, USA

Wednesday, March 16 | 8:00AM - 11:00AM
Adult Pancreatic Stem Cells (Joint)
Room: Longs/Grays Peak

Speaker 2 of 7
* Markus Grompe, Oregon Health & Science University, USA

Wednesday, March 16 | 8:00AM - 11:00AM
Adult Pancreatic Stem Cells (Joint)
Room: Longs/Grays Peak

Speaker 3 of 7
Matthias Hebrok, University of California, San Francisco, USA
Cellular Plasticity in the Adult Pancreas

Wednesday, March 16 | 8:00AM - 11:00AM
Adult Pancreatic Stem Cells (Joint)
Room: Longs/Grays Peak

Speaker 4 of 7
Joe Q. Zhou, Weill Cornell Medical College, USA
Renewable Generation of Functional Insulin+ Cells from Gastric Tissues

Wednesday, March 16 | 8:00AM - 11:00AM
Adult Pancreatic Stem Cells (Joint)
Room: Longs/Grays Peak

Speaker 5 of 7
Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Regulation of Pancreatic Beta Cell Identity

Wednesday, March 16 | 8:00AM - 11:00AM
Adult Pancreatic Stem Cells (Joint)
Room: Longs/Grays Peak

Speaker 6 of 7
Maike Sander, University of California, San Diego, USA
Chromatin State in Beta cell Development and Function

Wednesday, March 16 | 8:00AM - 11:00AM
Adult Pancreatic Stem Cells (Joint)
Room: Longs/Grays Peak

Speaker 7 of 7
Stephanie A. Campbell, Child and Family Research Institute, Canada
Short Talk: Trithorax Group Complexes are Essential for Pancreatic Endocrine and Exocrine Cell Specification

Wednesday, March 16 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, March 16 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Wednesday, March 16 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, March 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Wednesday, March 16 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, March 16 | 5:00PM - 7:00PM
Beta-Cell Stress
Room: Longs Peak

Speaker 1 of 5
* Ernesto Bernal-Mizrachi, University of Miami Miller School of Medicine, USA

Wednesday, March 16 | 5:00PM - 7:00PM
Beta-Cell Stress
Room: Longs Peak

Speaker 2 of 5
Miriam Cnop, Universite Libre de Bruxelles, Belgium
Mechanisms of Pancreatic Beta-cell Death in Type 2 Diabetes

Wednesday, March 16 | 5:00PM - 7:00PM
Beta-Cell Stress
Room: Longs Peak

Speaker 3 of 5
Marc Y. Donath, University Hospital Basel, Switzerland
Physiology of Pro-Inflammatory Cytokines in Metabolism: Therapeutic Consequences

Wednesday, March 16 | 5:00PM - 7:00PM
Beta-Cell Stress
Room: Longs Peak

Speaker 4 of 5
Roland W. Stein, Vanderbilt University Medical Center, USA
Examining How the MAFA and MAFB Transcription Factors Regulate Human Islet Beta Cell Function

Wednesday, March 16 | 5:00PM - 7:00PM
Beta-Cell Stress
Room: Longs Peak

Speaker 5 of 5
Maria S. Remedi, Washington University Medical School, USA
Short Talk: Plasticity of Pancreatic beta-cells: Dedifferentiation in Diabetes and Re-differentiation after Insulin Therapy

Wednesday, March 16 | 5:00PM - 7:00PM
Stem and Progenitor Cells in Homeostasis and Diseases
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 1 of 5
* Linheng Li, Stowers Institute for Medical Research, USA


Wednesday, March 16 | 5:00PM - 7:00PM
Stem and Progenitor Cells in Homeostasis and Diseases
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 2 of 5
Maureen Anne Gannon, Vanderbilt University Medical Center, USA
Expansion of Functional Pancreatic beta-Cell Mass Using Connective Tissue Growth Factor (CTGF)


Wednesday, March 16 | 5:00PM - 7:00PM
Stem and Progenitor Cells in Homeostasis and Diseases
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 3 of 5
Calvin Kuo, Stanford University, USA
Regulation of Intestinal Stem Cell Self-Renewal


Wednesday, March 16 | 5:00PM - 7:00PM
Stem and Progenitor Cells in Homeostasis and Diseases
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 4 of 5
Ben Z. Stanger, University of Pennsylvania, USA
Cellular Plasticity in the Liver


Wednesday, March 16 | 5:00PM - 7:00PM
Stem and Progenitor Cells in Homeostasis and Diseases
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 5 of 5
Mark Lewis, Washington University in St. Louis, USA
Short Talk: The Role of IFRD1 in Reprogramming Secretory Cells


Wednesday, March 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Wednesday, March 16 | 7:30PM - 10:00PM
Poster Session 3
Room: Red Cloud/Shavano/Torreys


Thursday, March 17 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Thursday, March 17 | 8:00AM - 11:15AM
Targeting Novel Drugs to the Islet
Room: Longs Peak

Speaker 1 of 7
* Carina Ammala, AstraZeneca, Sweden

Thursday, March 17 | 8:00AM - 11:15AM
Targeting Novel Drugs to the Islet
Room: Longs Peak

Speaker 2 of 7
Shalev Itzkovitz, Weizmann Institute of Science, Israel
EMBO Young Investigator Lecture: Single Molecule Approaches for Studying Gene Expression in Intact Mammalian Tissues

Thursday, March 17 | 8:00AM - 11:15AM
Targeting Novel Drugs to the Islet
Room: Longs Peak

Speaker 3 of 7
Andrew F. Stewart, Mount Sinai School of Medicine, USA
Progress and Hurdles in Human Beta Cell Regeneration for Diabetes

Thursday, March 17 | 8:00AM - 11:15AM
Targeting Novel Drugs to the Islet
Room: Longs Peak

Speaker 4 of 7
Robert A. Screaton, Sunnybrook Research Institute, Canada
Functional Genomics and the Human Pancreatic Beta Cell

Thursday, March 17 | 8:00AM - 11:15AM
Targeting Novel Drugs to the Islet
Room: Longs Peak

Speaker 5 of 7
Jesper Gromada, Regeneron Pharmaceuticals, USA
Single Islet Cell RNAseq for Target Discovery

Thursday, March 17 | 8:00AM - 11:15AM
Targeting Novel Drugs to the Islet
Room: Longs Peak

Speaker 6 of 7
Christian Helker, Max Planck Institute for Heart and Lung Research, Germany
Short Talk: Whole Organism Secretome-wide Screen to Identify Novel Regulators of Pancreatic Beta-Cell Function

Thursday, March 17 | 8:00AM - 11:15AM
Targeting Novel Drugs to the Islet
Room: Longs Peak

Speaker 7 of 7
Samuel B. Stephens, Duke University Medical Center, USA
Short Talk: Loss of the Pro-hormone VGF Decreases beta-cell Function via Reduced Insulin Secretory Granule Biogenesis

Thursday, March 17 | 9:00AM - 11:15AM
Developmental Origin of Stem Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 1 of 5
* James M. Wells, Cincinnati Children's Hospital Research Foundation, USA


Thursday, March 17 | 9:00AM - 11:15AM
Developmental Origin of Stem Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 2 of 5
Jason R. Spence, University of Michigan Health System, USA
Pluripotent Stem Cell Derived Organoid Models to Study Human Development


Thursday, March 17 | 9:00AM - 11:15AM
Developmental Origin of Stem Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 3 of 5
Atsushi Suzuki, Medical Institute of Bioregulation, Kyushu University, Japan
Stem Cell Systems in the Liver


Thursday, March 17 | 9:00AM - 11:15AM
Developmental Origin of Stem Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 4 of 5
Olivia G. Kelly, Viacyte, Inc., USA
Stem-Cell Derived, Macroencapsulated Islet Replacement for Type 1 Diabetes


Thursday, March 17 | 9:00AM - 11:15AM
Developmental Origin of Stem Cells
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 5 of 5
Somdutta Mukherjee, University of Pennsylvania, USA
Short Talk: Investigating the Role of TBX3 in Endodermal Progenitor Cell Maintenance and Differentiation


Thursday, March 17 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 17 | 11:15AM - 2:30PM
On Own for Lunch


Thursday, March 17 | 2:30PM - 4:30PM
Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu
nctions
Room: Longs Peak

Speaker 1 of 9
* Chris Wright, Vanderbilt University Medical Center, USA

Thursday, March 17 | 2:30PM - 4:30PM
Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu
nctions
Room: Longs Peak

Speaker 2 of 9
Aimee Bastidas Ponce, Helmholtz Zentrum Munich, Germany
Analysis of the Role of Synaptotagmin 13 in Pancreatic Beta-cell Function and Islet Architecture

Thursday, March 17 | 2:30PM - 4:30PM
Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu
nctions
Room: Longs Peak

Speaker 3 of 9
Esther Marie Bolanis, Indiana University School of Medicine, USA
Posttranslational Modification of the Factor eIF5A is Required for the Adaptive Response of the Islet Beta Cell During Insulin Resistance

Thursday, March 17 | 2:30PM - 4:30PM
Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu
nctions
Room: Longs Peak

Speaker 4 of 9
Gitte Lund Christensen, University of Copenhagen, Denmark
Pancreatic beta-cells Dysfunction Induced by Prolonged Exposure to Low Dose IL1beta or Bmp2 is associated with beta-cell De-differentiation

Thursday, March 17 | 2:30PM - 4:30PM
Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu
nctions
Room: Longs Peak

Speaker 5 of 9
Jennifer L. Estall, Institut de Recherches Cliniques de Montréal, Canada
Pgc-1 Coactivators in beta-cells are Essential for Glycerolipid Metabolism and Insulin Secretion Coupled to Fatty Acids

Thursday, March 17 | 2:30PM - 4:30PM
Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu
nctions
Room: Longs Peak

Speaker 6 of 9
Amanda M. Ackermann, Children's Hospital of Philadelphia, USA
Integration of ATAC-seq and RNA-seq Identifies Human Alpha Cell and Beta Cell
Signature Genes


Thursday, March 17 | 2:30PM - 4:30PM
Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu
nctions
Room: Longs Peak

Speaker 7 of 9
Aharon Helman, Harvard University, USA
p16Ink4a-induced Senescence of Pancreatic beta-cells Enhances Insulin Secretion

Thursday, March 17 | 2:30PM - 4:30PM
Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu
nctions
Room: Longs Peak

Speaker 8 of 9
Aida Martinez-Sanchez, Imperial College London, UK
Disallowance of Acot7 in Beta-cells is Required for Normal Insulin Secretion and Glucose Tolerance

Thursday, March 17 | 2:30PM - 4:30PM
Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu
nctions
Room: Longs Peak

Speaker 9 of 9
Lu Zhu, NIDDK, National Institutes of Health, USA
Beta-Arrestin-2 is an Essential Regulator of Pancreatic beta-cell Function

Thursday, March 17 | 2:30PM - 4:30PM
Workshop and Panel Discussion 2: Hurdles to Translation
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 1 of 7
* Martín G. Martín, David Geffen School of Medicine at UCLA, USA


Thursday, March 17 | 2:30PM - 4:30PM
Workshop and Panel Discussion 2: Hurdles to Translation
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 2 of 7
Shinichiro Ogawa, McEwen Centre for Regenerative Medicine, Canada
Modeling Cystic Fibrosis Biliary Disease with hPSC-Derived Cholangiocyte


Thursday, March 17 | 2:30PM - 4:30PM
Workshop and Panel Discussion 2: Hurdles to Translation
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 3 of 7
Casey Allison Rimland, Cambridge University, UK
Progenitor Cells in the Human Extrahepatic Biliary Tree and Gallbladder


Thursday, March 17 | 2:30PM - 4:30PM
Workshop and Panel Discussion 2: Hurdles to Translation
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 4 of 7
Ken Woo, University of Western Australia, Australia
Liver Progenitor Cells Derived from Pluripotent Stem Cells


Thursday, March 17 | 2:30PM - 4:30PM
Workshop and Panel Discussion 2: Hurdles to Translation
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 5 of 7
Christopher Heinen, University of Connecticut Health, USA
The DNA Mismatch Repair-Dependent Damage Response in Human Embryonic Stem Cell-Derived Intestinal Organoids


Thursday, March 17 | 2:30PM - 4:30PM
Workshop and Panel Discussion 2: Hurdles to Translation
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 6 of 7
Maelle Lorvellec, University College London, UK
Differentiation of human Embryonic Stem Cells and Induced Pluripotent Stem Cells into Hepatocytes-like Cells in a Mouse Decellularized Liver Scaffold


Thursday, March 17 | 2:30PM - 4:30PM
Workshop and Panel Discussion 2: Hurdles to Translation
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 7 of 7
Li-Fang Chu, University of Wisconsin-Madison, USA
Single-cell RNA-seq Reveals Novel Regulators of Human Embryonic Stem Cell Differentiation to Definitive Endoderm


Thursday, March 17 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 17 | 5:00PM - 6:45PM
Type-1 Diabetes: The Beta-Cell Immune System Interface
Room: Longs Peak

Speaker 1 of 4
* Miriam Cnop, Universite Libre de Bruxelles, Belgium

Thursday, March 17 | 5:00PM - 6:45PM
Type-1 Diabetes: The Beta-Cell Immune System Interface
Room: Longs Peak

Speaker 2 of 4
Mark A. Atkinson, University of Florida, USA
The Pathogenesis of Human Type 1 Diabetes - A Disease of the Immune System, Beta Cells and Pancreas

Thursday, March 17 | 5:00PM - 6:45PM
Type-1 Diabetes: The Beta-Cell Immune System Interface
Room: Longs Peak

Speaker 3 of 4
Carla J. Greenbaum, Benaroya Research Institute at Virginia Mason, USA
T1D Therapeutic Approaches

Thursday, March 17 | 5:00PM - 6:45PM
Type-1 Diabetes: The Beta-Cell Immune System Interface
Room: Longs Peak

Speaker 4 of 4
Rene Maehr, University of Massachusetts Medical School, USA
Towards a Human Pluripotent Stem Cell-Based Disease Model for Autoimmune Diabetes

Thursday, March 17 | 5:00PM - 6:45PM
Translational and Clinical Applications
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 1 of 4
* Jill L. Carrington, National Institute of Diabetes and Digestive and Kidney Diseases, USA


Thursday, March 17 | 5:00PM - 6:45PM
Translational and Clinical Applications
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 2 of 4
Tsutomu Chiba, Kyoto University, Japan
Double Cortin-Like Kinase 1 (Dclk1) Marks PanIN-initiating Cells in Acinar-to-Ductal Metaplasia (ADM)


Thursday, March 17 | 5:00PM - 6:45PM
Translational and Clinical Applications
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 3 of 4
William Proctor, Genentech, Inc., USA
Role of PI3Kalpha and mTOR Inhibition in Endoderm Differentiation as a First Step toward Personalized Toxicology


Thursday, March 17 | 5:00PM - 6:45PM
Translational and Clinical Applications
This session is from Stem Cells and Regeneration
Room: Grays Peak

Speaker 4 of 4
Martín G. Martín, David Geffen School of Medicine at UCLA, USA
Intestinal Stem Cells - Bench to Bedside, and Future Challenges


Thursday, March 17 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Longs Peak


Thursday, March 17 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Stem Cells and Regeneration
Room: Grays Peak


Thursday, March 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Thursday, March 17 | 8:00PM - 11:00PM
Entertainment
Room: Red Cloud/Shavano/Torreys
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 17 | 8:00PM - 11:00PM
Cash Bar
Room: Red Cloud/Shavano/Torreys


Friday, March 18 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.