Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Islet Biology: From Gene to Cell to Micro-Organ (2020J6)
Frontiers in Islet Biology and Diabetes (2018B3)

Web Desc
Islet Biology: From Cell Birth to Death joint with Stem Cells and Regeneration in the Digestive Organs Organizer(s): Klaus H. Kaestner, Christopher J. Rhodes and Yuval Dor Date: March 13 - 17, 2016 Location: Keystone Resort, Keystone, CO, USA Sponsored by MedImmune and Novo Nordisk A/S For important information on the coronavirus, please click here Summary of Meeting: The islets of Langerhans, endocrine micro-organs within the pancreas, are at the center of multiple metabolic diseases, from hyperinsulinism to diabetes. Islets elaborate the key hormones, glucagon and insulin that control glucose homeostasis, and their dysfunction in diabetes causes severe morbidity in more than 300 million people worldwide, with associated healthcare costs in the hundreds of billions of dollars annually. This Keystone Symposia meeting covers innovative research in all aspects of islet biology, from the developmental origin of endocrine cell types in fetal life, to beta-cell failure in type 2 diabetes. The specific goals of the conference are to: 1) Present unpublished data that cover critical knowledge gaps in the field; 2) Evaluate the state of the art of novel therapeutics for diabetes, including cell replacement therapies; and 3) Provide training for young investigators in the field. New international collaborations fostered by this conference should accelerate progress in this important field of biomedical research. Scholarship Deadline: November 12 2015 Discounted Abstract Deadline: November 12 2015 Abstract Deadline: December 15 2015 Discounted Registration Deadline: January 14 2016 Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested. Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: MedImmune Regeneron Pharmaceuticals, Inc. We gratefully acknowledge the generous grant for this conference provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Grant No. 1R13DK108622-01 The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Islet Biology: From Cell Birth to Death

joint with Stem Cells and Regeneration in the Digestive Organs

Organizer(s): Klaus H. Kaestner, Christopher J. Rhodes and Yuval Dor

Date: March 13 - 17, 2016
Location: Keystone Resort, Keystone, CO, USA

Sponsored by MedImmune and Novo Nordisk A/S

For important information on the coronavirus, please click here

Summary of Meeting:

The islets of Langerhans, endocrine micro-organs within the pancreas, are at the center of multiple metabolic diseases, from hyperinsulinism to diabetes. Islets elaborate the key hormones, glucagon and insulin that control glucose homeostasis, and their dysfunction in diabetes causes severe morbidity in more than 300 million people worldwide, with associated healthcare costs in the hundreds of billions of dollars annually. This Keystone Symposia meeting covers innovative research in all aspects of islet biology, from the developmental origin of endocrine cell types in fetal life, to beta-cell failure in type 2 diabetes. The specific goals of the conference are to: 1) Present unpublished data that cover critical knowledge gaps in the field; 2) Evaluate the state of the art of novel therapeutics for diabetes, including cell replacement therapies; and 3) Provide training for young investigators in the field. New international collaborations fostered by this conference should accelerate progress in this important field of biomedical research.

Scholarship Deadline: November 12 2015

Discounted Abstract Deadline: November 12 2015

Abstract Deadline: December 15 2015

Discounted Registration Deadline: January 14 2016

Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

MedImmune

Regeneron Pharmaceuticals, Inc.

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK108622-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 13 \| 4:00PM - 8:00PM Arrival and Registration Room: Longs Peak Foyer
Sunday, March 13 \| 6:00PM - 8:00PM Welcome Mixer Room: Longs Peak Foyer No registration fees are used to fund alcohol served at this function.
Monday, March 14 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Monday, March 14 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Grays/Longs Peak Speaker 1 of 3 * Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
Monday, March 14 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Grays/Longs Peak Speaker 2 of 3 * Linheng Li, Stowers Institute for Medical Research, USA
Monday, March 14 \| 8:00AM - 9:00AM Welcome and Keynote Address (Joint) Room: Grays/Longs Peak Speaker 3 of 3 Hiromitsu Nakauchi, Stanford University, USA Interspecific Blastocyst Complementation: Can Patient-Specific Islets of Langerhans Be Generated in Pigs?
Monday, March 14 \| 9:00AM - 9:30AM Coffee Break Room: Longs Peak Foyer
Monday, March 14 \| 9:30AM - 11:45AM Developmental and Regenerative Biology of the Endocrine Panc reas Room: Longs Peak Speaker 1 of 6 * Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Monday, March 14 \| 9:30AM - 11:45AM Developmental and Regenerative Biology of the Endocrine Panc reas Room: Longs Peak Speaker 2 of 6 Anne Grapin-Botton, University of Copenhagen, Denmark Progenitor Heterogeneity as a Driver of Pancreas Development
Monday, March 14 \| 9:30AM - 11:45AM Developmental and Regenerative Biology of the Endocrine Panc reas Room: Longs Peak Speaker 3 of 6 Chris Wright, Vanderbilt University Medical Center, USA Intra-Islet Endocrine-Cell Communication and the Control of Beta-Cell Number and Replication State
Monday, March 14 \| 9:30AM - 11:45AM Developmental and Regenerative Biology of the Endocrine Panc reas Room: Longs Peak Speaker 4 of 6 Seung K. Kim, Stanford University, USA Signaling Regulation of Islet Morphogenesis
Monday, March 14 \| 9:30AM - 11:45AM Developmental and Regenerative Biology of the Endocrine Panc reas Room: Longs Peak Speaker 5 of 6 Caitlin Braitsch, University of Texas Southwestern Medical Center, USA Short Talk: Hippo-Warts Pathway Regulation of Pancreatic Epithelial Architecture and Progenitor Cell Fate
Monday, March 14 \| 9:30AM - 11:45AM Developmental and Regenerative Biology of the Endocrine Panc reas Room: Longs Peak Speaker 6 of 6 Alireza Rezania, CRISPR Therapeutics, USA Short Talk: In vitro Generation of Insulin-producing Cells with Insulin Secretion Dynamics and Mitochondrial Metabolism Similar to Adult Human Islets
Monday, March 14 \| 9:30AM - 11:30AM GI Lineages from Pluripotent Stem Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 1 of 5 * Stephen A. Duncan, Medical University of South Carolina, USA
Monday, March 14 \| 9:30AM - 11:30AM GI Lineages from Pluripotent Stem Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 2 of 5 Gordon M. Keller, University Health Network, MaRS Centre, Canada Patterning Human Pluripotent Stem Cell-Derived Endoderm
Monday, March 14 \| 9:30AM - 11:30AM GI Lineages from Pluripotent Stem Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 3 of 5 Paul Gadue, Children's Hospital of Philadelphia, USA GATA6 Regulation of Endoderm and Pancreatic Development from Human Pluripotent Stem Cells
Monday, March 14 \| 9:30AM - 11:30AM GI Lineages from Pluripotent Stem Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 4 of 5 James M. Wells, Cincinnati Children's Hospital Research Foundation, USA Human Pluripotent Stem Cell-Derived Tissues as New Models to Study Development and Disease of the Digestive Tract
Monday, March 14 \| 9:30AM - 11:30AM GI Lineages from Pluripotent Stem Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 5 of 5 Alexander Kleger, Ulm University, Germany Short Talk: Human Pluripotent Stem Cell-Derived Pancreatic Organoids to Study Cystic Fibrosis in a Dish
Monday, March 14 \| 11:45AM - 1:00PM Poster Setup Room: Red Cloud/Shavano/Torreys
Monday, March 14 \| 11:45AM - 2:30PM On Own for Lunch
Monday, March 14 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano/Torreys
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Pancreatic Islet Cell Development, Growth and Re generation Room: Longs Peak Speaker 1 of 9 * Doris A. Stoffers, Perelman School of Medicine, University of Pennsylvania, USA
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Pancreatic Islet Cell Development, Growth and Re generation Room: Longs Peak Speaker 2 of 9 Yunus Alpagu, IMB-ASTAR, Singapore Modelling Mitchell-Riley Syndrome in vitro using iPS Cells Derived from a RFX6 Mutant Patient
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Pancreatic Islet Cell Development, Growth and Re generation Room: Longs Peak Speaker 3 of 9 Caitlin Collin, University of Copenhagen, Denmark The Function of Notch Ligands in Pancreas Development
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Pancreatic Islet Cell Development, Growth and Re generation Room: Longs Peak Speaker 4 of 9 Nidheesh Dadheech, University of Alberta, Canada GLP-1 Induces Neurog3 Re-expression and Beta-Cell Neogenesis in Adult Mice
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Pancreatic Islet Cell Development, Growth and Re generation Room: Longs Peak Speaker 5 of 9 Benjamin Neal Ediger, University of Pennsylvania, USA Ldb1 Maintains the Terminally Differentiated State of Pancreatic Beta-cells through a Functional Interaction with Isl-1
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Pancreatic Islet Cell Development, Growth and Re generation Room: Longs Peak Speaker 6 of 9 Katie L. Sinagoga, Cincinnati Children's Hospital Medical Center, USA mTOR Regulates Postnatal Morphogenesis, Maturation, and Function of Murine Islets
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Pancreatic Islet Cell Development, Growth and Re generation Room: Longs Peak Speaker 7 of 9 Francesca M. Spagnoli, Max Delbrück Center for Molecular Medicine, Germany Axon Guidance Signaling Controls Pancreatic Cell Identity
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Pancreatic Islet Cell Development, Growth and Re generation Room: Longs Peak Speaker 8 of 9 Amita Tiyaboonchai, University of Pennsylvania, USA GATA6 in Human Endoderm and Pancreatic Development from Human Pluripotent Stem Cells
Monday, March 14 \| 2:30PM - 4:30PM Workshop 1: Pancreatic Islet Cell Development, Growth and Re generation Room: Longs Peak Speaker 9 of 9 Pei Wang, University of Texas Health Science Center at San Antonio, USA Investigating the Role of the Hippo Signaling Pathway in Pancreatic Endocrine Cell Development and Beta Cell Proliferation
Monday, March 14 \| 2:30PM - 4:30PM Workshop and Panel Discussion 1: Tissue Engineering This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 1 of 6 * Mo Ebrahimkhani, Arizona State University, USA Engineering Self-Organization of Human Pluripotent Stem Cells to a Fetal Liver-Like Tissue
Monday, March 14 \| 2:30PM - 4:30PM Workshop and Panel Discussion 1: Tissue Engineering This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 2 of 6 Bruce M. Wang, Stanford University, USA Self-Renewing Diploid Axin2+ Cells Fuel Homeostatic Renewal of the Liver
Monday, March 14 \| 2:30PM - 4:30PM Workshop and Panel Discussion 1: Tissue Engineering This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 3 of 6 Joseph J. Lancman, Sanford Burnham Presbys Medical Discovery Institute, USA Induced in vivo Cell Reprogramming of Muscle into Endoderm Lineages
Monday, March 14 \| 2:30PM - 4:30PM Workshop and Panel Discussion 1: Tissue Engineering This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 4 of 6 Kay Wiebrands, Hubrecht Institute, Netherlands Single-Cell RNA Sequencing Reveals Divergence of Lgr5+ Stem Cells during Development of the Gastrointestinal Tract
Monday, March 14 \| 2:30PM - 4:30PM Workshop and Panel Discussion 1: Tissue Engineering This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 5 of 6 Alan C. Mullen, Harvard Medical School, USA DIGIT is a Conserved Long Noncoding RNA that Regulates Goosecoid Expression to Control Endoderm Differentiation of Human Embryonic Stem Cells
Monday, March 14 \| 2:30PM - 4:30PM Workshop and Panel Discussion 1: Tissue Engineering This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 6 of 6 * Jan Jensen, Lerner Research Institute, USA Understanding Multi-Lineage Differentiation of Endodermal Progenitor Cells using a Systems Developmental Biology Approach
Monday, March 14 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, March 14 \| 5:00PM - 7:00PM Controlling Beta-Cell Function Room: Longs Peak Speaker 1 of 4 * Alvin C. Powers, Vanderbilt University School of Medicine, USA
Monday, March 14 \| 5:00PM - 7:00PM Controlling Beta-Cell Function Room: Longs Peak Speaker 2 of 4 Doris A. Stoffers, Perelman School of Medicine, University of Pennsylvania, USA Mining the Pdx1 Cistrome for Novel Insights into Diabetes
Monday, March 14 \| 5:00PM - 7:00PM Controlling Beta-Cell Function Room: Longs Peak Speaker 3 of 4 Christopher J. Rhodes, AstraZeneca, USA CNS Control of Pancreatic Islet-Cell Function
Monday, March 14 \| 5:00PM - 7:00PM Controlling Beta-Cell Function Room: Longs Peak Speaker 4 of 4 Cristina M. Rondinone, Cellarity Inc., USA Novel Direct and Indirect Ways to Improve Beta Cell Health
Monday, March 14 \| 5:00PM - 7:00PM Disease Modeling This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 1 of 5 * Gordon M. Keller, University Health Network, MaRS Centre, Canada
Monday, March 14 \| 5:00PM - 7:00PM Disease Modeling This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 2 of 5 Frederic J. de Sauvage, Genentech, Inc., USA Targeting Intestinal Stem Cells in Cancer
Monday, March 14 \| 5:00PM - 7:00PM Disease Modeling This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 3 of 5 Stephen A. Duncan, Medical University of South Carolina, USA Disease Modeling with ESC/iPSCs-Derived Hepatocyte-Like Cells
Monday, March 14 \| 5:00PM - 7:00PM Disease Modeling This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 4 of 5 Holger Willenbring, University of California, San Francisco, USA Liver Cell Therapy with Hepatocytes Derived from Pluripotent Stem Cells
Monday, March 14 \| 5:00PM - 7:00PM Disease Modeling This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 5 of 5 Tobias Cantz, Hannover Medical School, Germany Short Talk: Patient-Specific iPS Cell-Based Hepatic Cells Allow Modeling of Transthyretin-Related Familial Amyloid Polyneuropathy
Monday, March 14 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Monday, March 14 \| 7:30PM - 10:00PM Poster Session 1 Room: Red Cloud/Shavano/Torreys
Tuesday, March 15 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Tuesday, March 15 \| 8:00AM - 11:15AM Beta-Cell Growth and Proliferation Room: Longs Peak Speaker 1 of 7 * Andrew F. Stewart, Mount Sinai School of Medicine, USA
Tuesday, March 15 \| 8:00AM - 11:15AM Beta-Cell Growth and Proliferation Room: Longs Peak Speaker 2 of 7 Yuval Dor, Hebrew University-Hadassah Medical School, Israel The Genetic Program of Replicating beta Cells
Tuesday, March 15 \| 8:00AM - 11:15AM Beta-Cell Growth and Proliferation Room: Longs Peak Speaker 3 of 7 Heiko Lickert, Institute of Diabetes and Regeneration, Germany Identification of Proliferative and Mature B-cells in the Islet of Langerhans
Tuesday, March 15 \| 8:00AM - 11:15AM Beta-Cell Growth and Proliferation Room: Longs Peak Speaker 4 of 7 Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA The Epigenome during Beta-Cell Maturation
Tuesday, March 15 \| 8:00AM - 11:15AM Beta-Cell Growth and Proliferation Room: Longs Peak Speaker 5 of 7 Jorge Ferrer, Imperial College London, UK Long Noncoding RNAs in Beta-Cells
Tuesday, March 15 \| 8:00AM - 11:15AM Beta-Cell Growth and Proliferation Room: Longs Peak Speaker 6 of 7 Justin P. Annes, Stanford University, USA Short Talk: Multi-ligand Targeting of DYRK1A/B and Casein Kinase1gamma2 Promotes beta-cell Replication
Tuesday, March 15 \| 8:00AM - 11:15AM Beta-Cell Growth and Proliferation Room: Longs Peak Speaker 7 of 7 Bethany A. Carboneau, Vanderbilt University, USA Short Talk: Regulation of Beta-Cell Mass Expansion by Prostaglandin E2 Signaling
Tuesday, March 15 \| 8:00AM - 11:00AM Identity and Function of GI Stem and Progenitor Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 1 of 6 * Hans C. Clevers, Hubrecht Institute, Netherlands
Tuesday, March 15 \| 8:00AM - 11:00AM Identity and Function of GI Stem and Progenitor Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 2 of 6 Frédéric Lemaigre, de Duve Institute and Université Catholique de Louvain, Belgium Dynamics of Hepatic Cell Differentiation Depend on microRNA-Dependent Regulatory Motifs
Tuesday, March 15 \| 8:00AM - 11:00AM Identity and Function of GI Stem and Progenitor Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 3 of 6 Stuart J. Forbes, University of Edinburgh, UK The Role of Hepatic Progenitor Cells in Liver Regeneration
Tuesday, March 15 \| 8:00AM - 11:00AM Identity and Function of GI Stem and Progenitor Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 4 of 6 Timothy C. Wang, Columbia University, USA Gastric Stem Cells and Their Niches
Tuesday, March 15 \| 8:00AM - 11:00AM Identity and Function of GI Stem and Progenitor Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 5 of 6 Linheng Li, Stowers Institute for Medical Research, USA Characterization of Drug-resistant Quiescent Stem Cells in Intestine
Tuesday, March 15 \| 8:00AM - 11:00AM Identity and Function of GI Stem and Progenitor Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 6 of 6 Nicholas R. Smith, Oregon Health & Science University, USA Short Talk: Bmi1-Expressing Intestinal Stem Cells Drive Emergency Re-Epithelialization
Tuesday, March 15 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Tuesday, March 15 \| 11:15AM - 1:00PM Poster Setup Room: Red Cloud/Shavano/Torreys
Tuesday, March 15 \| 11:15AM - 5:00PM On Own for Lunch
Tuesday, March 15 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano/Torreys
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Pancreatic Beta-Cell Death and Survival Room: Longs Peak Speaker 1 of 9 * Guy A. Rutter, Imperial College London, UK
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Pancreatic Beta-Cell Death and Survival Room: Longs Peak Speaker 2 of 9 Michal Aharoni-Simon, University of British Columbia, Canada Anti-Apoptotic Bcl-2 Regulates Reactive Oxygen Species Signaling and a Redox-Sensitive Mitochondrial Proton Leak in Mouse Pancreatic beta-Cells
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Pancreatic Beta-Cell Death and Survival Room: Longs Peak Speaker 3 of 9 Lukas Adrian Berchtold, University of Copenhagen, Denmark Pannexin-2 is an Anti-Apoptotic Protein in Pancreatic beta-Cells
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Pancreatic Beta-Cell Death and Survival Room: Longs Peak Speaker 4 of 9 Anne Close, University of Alberta, Canada The Nuclear Receptor Nor1/Nr4a3 Mediates Cytokines-induced beta-cell Apoptosis and Regulates beta-cell Mass
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Pancreatic Beta-Cell Death and Survival Room: Longs Peak Speaker 5 of 9 Yong Kyung Kim, University of Colorado, Anshcutz Medical Campus, USA Disruption of Mitochondrial Crif1 (CR6-interacting factor-1) in Mouse beta Cells Leads to Diabetes with Progressive beta Cell Failure
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Pancreatic Beta-Cell Death and Survival Room: Longs Peak Speaker 6 of 9 Amelia K. Linnemann, University of Wisconsin-Madison, USA Interleukin-6 Stimulates Autophagy in Pancreatic beta-cells and Protects against Apoptosis
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Pancreatic Beta-Cell Death and Survival Room: Longs Peak Speaker 7 of 9 Michelle E. Kimple, University of Wisconsin, Madison, USA G-protein-mediated Mechanisms Linking Beta-cell Death, Dysfunction, and Decompensation in Diabetes
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Pancreatic Beta-Cell Death and Survival Room: Longs Peak Speaker 8 of 9 Jason M. Tonne, Mayo Clinic, USA Nestin-positive Pericytes Facilitate beta-cell-protection through Prevention of Excessive beta-cell-targeted Immune Reactions and Promotion of beta-cell Regeneration in Insulitis
Tuesday, March 15 \| 2:30PM - 4:30PM Workshop 2: Pancreatic Beta-Cell Death and Survival Room: Longs Peak Speaker 9 of 9 Brett S. Peterson, Duke University, USA Delayed Apoptosis Allows Islet beta-cells to Implement an Autophagic Mechanism to Promote Cell Survival
Tuesday, March 15 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, March 15 \| 5:00PM - 7:00PM Other Islet Cell Types: Major Contributor to Glucose Homeost asis and Health? Room: Longs Peak Speaker 1 of 5 * Nils Billestrup, University of Copenhagen, Denmark
Tuesday, March 15 \| 5:00PM - 7:00PM Other Islet Cell Types: Major Contributor to Glucose Homeost asis and Health? Room: Longs Peak Speaker 2 of 5 Alvin C. Powers, Vanderbilt University School of Medicine, USA Interactions of Endothelial Cells, Macrophages, and Islet Cells
Tuesday, March 15 \| 5:00PM - 7:00PM Other Islet Cell Types: Major Contributor to Glucose Homeost asis and Health? Room: Longs Peak Speaker 3 of 5 Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK ATP-Regulated Potassium Channels in the Regulation of Glucagon Secretion
Tuesday, March 15 \| 5:00PM - 7:00PM Other Islet Cell Types: Major Contributor to Glucose Homeost asis and Health? Room: Longs Peak Speaker 4 of 5 Per-Olof Berggren, Karolinska Institutet, Sweden Insight Into Pancreatic Islet Cell Physiology/Pathology
Tuesday, March 15 \| 5:00PM - 7:00PM Other Islet Cell Types: Major Contributor to Glucose Homeost asis and Health? Room: Longs Peak Speaker 5 of 5 Guy A. Rutter, Imperial College London, UK Short Talk: Deletion of the Type 2 Diabetes-associated Gene StarD10 in Mice Impairs Insulin Secretion and Action
Tuesday, March 15 \| 5:00PM - 7:00PM Programmed or Reprogrammed Regeneration This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 1 of 5 * Holger Willenbring, University of California, San Francisco, USA
Tuesday, March 15 \| 5:00PM - 7:00PM Programmed or Reprogrammed Regeneration This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 2 of 5 Lijian Hui, Shanghai Institutes of Biological Sciences, China Direct Reprogramming of Human Fibroblasts to Functional Hepatocyte-Like Cells
Tuesday, March 15 \| 5:00PM - 7:00PM Programmed or Reprogrammed Regeneration This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 3 of 5 Louise Laurent, University of California, San Diego, USA Using Single-Cell Transcriptomics to Discover Cellular Reprogramming Factors for Autologous Cell Replacement Therapy for Type 1 Diabetes
Tuesday, March 15 \| 5:00PM - 7:00PM Programmed or Reprogrammed Regeneration This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 4 of 5 Markus Grompe, Oregon Health & Science University, USA Tissue Regeneration in Liver: Plasticity or Stem Cells?
Tuesday, March 15 \| 5:00PM - 7:00PM Programmed or Reprogrammed Regeneration This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 5 of 5 Claude Gérard, Université Catholique de Louvain, Belgium Short Talk: A Mathematical Model for the Transcription Factor Network Driving Hepatocyte Differentiation
Tuesday, March 15 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Tuesday, March 15 \| 7:30PM - 10:00PM Poster Session 2 Room: Red Cloud/Shavano/Torreys
Wednesday, March 16 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Wednesday, March 16 \| 8:00AM - 11:00AM Adult Pancreatic Stem Cells (Joint) Room: Longs/Grays Peak Speaker 1 of 7 * Catherine Lee May, University of Pennsylvania, USA
Wednesday, March 16 \| 8:00AM - 11:00AM Adult Pancreatic Stem Cells (Joint) Room: Longs/Grays Peak Speaker 2 of 7 * Markus Grompe, Oregon Health & Science University, USA
Wednesday, March 16 \| 8:00AM - 11:00AM Adult Pancreatic Stem Cells (Joint) Room: Longs/Grays Peak Speaker 3 of 7 Matthias Hebrok, University of California, San Francisco, USA Cellular Plasticity in the Adult Pancreas
Wednesday, March 16 \| 8:00AM - 11:00AM Adult Pancreatic Stem Cells (Joint) Room: Longs/Grays Peak Speaker 4 of 7 Joe Q. Zhou, Weill Cornell Medical College, USA Renewable Generation of Functional Insulin+ Cells from Gastric Tissues
Wednesday, March 16 \| 8:00AM - 11:00AM Adult Pancreatic Stem Cells (Joint) Room: Longs/Grays Peak Speaker 5 of 7 Lori Sussel, University of Colorado Anschutz Medical Campus, USA Regulation of Pancreatic Beta Cell Identity
Wednesday, March 16 \| 8:00AM - 11:00AM Adult Pancreatic Stem Cells (Joint) Room: Longs/Grays Peak Speaker 6 of 7 Maike Sander, University of California, San Diego, USA Chromatin State in Beta cell Development and Function
Wednesday, March 16 \| 8:00AM - 11:00AM Adult Pancreatic Stem Cells (Joint) Room: Longs/Grays Peak Speaker 7 of 7 Stephanie A. Campbell, Child and Family Research Institute, Canada Short Talk: Trithorax Group Complexes are Essential for Pancreatic Endocrine and Exocrine Cell Specification
Wednesday, March 16 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Wednesday, March 16 \| 11:00AM - 1:00PM Poster Setup Room: Red Cloud/Shavano/Torreys
Wednesday, March 16 \| 11:00AM - 5:00PM On Own for Lunch
Wednesday, March 16 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano/Torreys
Wednesday, March 16 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, March 16 \| 5:00PM - 7:00PM Beta-Cell Stress Room: Longs Peak Speaker 1 of 5 * Ernesto Bernal-Mizrachi, University of Miami Miller School of Medicine, USA
Wednesday, March 16 \| 5:00PM - 7:00PM Beta-Cell Stress Room: Longs Peak Speaker 2 of 5 Miriam Cnop, Universite Libre de Bruxelles, Belgium Mechanisms of Pancreatic Beta-cell Death in Type 2 Diabetes
Wednesday, March 16 \| 5:00PM - 7:00PM Beta-Cell Stress Room: Longs Peak Speaker 3 of 5 Marc Y. Donath, University Hospital Basel, Switzerland Physiology of Pro-Inflammatory Cytokines in Metabolism: Therapeutic Consequences
Wednesday, March 16 \| 5:00PM - 7:00PM Beta-Cell Stress Room: Longs Peak Speaker 4 of 5 Roland W. Stein, Vanderbilt University Medical Center, USA Examining How the MAFA and MAFB Transcription Factors Regulate Human Islet Beta Cell Function
Wednesday, March 16 \| 5:00PM - 7:00PM Beta-Cell Stress Room: Longs Peak Speaker 5 of 5 Maria S. Remedi, Washington University Medical School, USA Short Talk: Plasticity of Pancreatic beta-cells: Dedifferentiation in Diabetes and Re-differentiation after Insulin Therapy
Wednesday, March 16 \| 5:00PM - 7:00PM Stem and Progenitor Cells in Homeostasis and Diseases This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 1 of 5 * Linheng Li, Stowers Institute for Medical Research, USA
Wednesday, March 16 \| 5:00PM - 7:00PM Stem and Progenitor Cells in Homeostasis and Diseases This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 2 of 5 Maureen Anne Gannon, Vanderbilt University Medical Center, USA Expansion of Functional Pancreatic beta-Cell Mass Using Connective Tissue Growth Factor (CTGF)
Wednesday, March 16 \| 5:00PM - 7:00PM Stem and Progenitor Cells in Homeostasis and Diseases This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 3 of 5 Calvin Kuo, Stanford University, USA Regulation of Intestinal Stem Cell Self-Renewal
Wednesday, March 16 \| 5:00PM - 7:00PM Stem and Progenitor Cells in Homeostasis and Diseases This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 4 of 5 Ben Z. Stanger, University of Pennsylvania, USA Cellular Plasticity in the Liver
Wednesday, March 16 \| 5:00PM - 7:00PM Stem and Progenitor Cells in Homeostasis and Diseases This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 5 of 5 Mark Lewis, Washington University in St. Louis, USA Short Talk: The Role of IFRD1 in Reprogramming Secretory Cells
Wednesday, March 16 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Wednesday, March 16 \| 7:30PM - 10:00PM Poster Session 3 Room: Red Cloud/Shavano/Torreys
Thursday, March 17 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano/Torreys
Thursday, March 17 \| 8:00AM - 11:15AM Targeting Novel Drugs to the Islet Room: Longs Peak Speaker 1 of 7 * Carina Ammala, AstraZeneca, Sweden
Thursday, March 17 \| 8:00AM - 11:15AM Targeting Novel Drugs to the Islet Room: Longs Peak Speaker 2 of 7 Shalev Itzkovitz, Weizmann Institute of Science, Israel EMBO Young Investigator Lecture: Single Molecule Approaches for Studying Gene Expression in Intact Mammalian Tissues
Thursday, March 17 \| 8:00AM - 11:15AM Targeting Novel Drugs to the Islet Room: Longs Peak Speaker 3 of 7 Andrew F. Stewart, Mount Sinai School of Medicine, USA Progress and Hurdles in Human Beta Cell Regeneration for Diabetes
Thursday, March 17 \| 8:00AM - 11:15AM Targeting Novel Drugs to the Islet Room: Longs Peak Speaker 4 of 7 Robert A. Screaton, Sunnybrook Research Institute, Canada Functional Genomics and the Human Pancreatic Beta Cell
Thursday, March 17 \| 8:00AM - 11:15AM Targeting Novel Drugs to the Islet Room: Longs Peak Speaker 5 of 7 Jesper Gromada, Regeneron Pharmaceuticals, USA Single Islet Cell RNAseq for Target Discovery
Thursday, March 17 \| 8:00AM - 11:15AM Targeting Novel Drugs to the Islet Room: Longs Peak Speaker 6 of 7 Christian Helker, Max Planck Institute for Heart and Lung Research, Germany Short Talk: Whole Organism Secretome-wide Screen to Identify Novel Regulators of Pancreatic Beta-Cell Function
Thursday, March 17 \| 8:00AM - 11:15AM Targeting Novel Drugs to the Islet Room: Longs Peak Speaker 7 of 7 Samuel B. Stephens, Duke University Medical Center, USA Short Talk: Loss of the Pro-hormone VGF Decreases beta-cell Function via Reduced Insulin Secretory Granule Biogenesis
Thursday, March 17 \| 9:00AM - 11:15AM Developmental Origin of Stem Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 1 of 5 * James M. Wells, Cincinnati Children's Hospital Research Foundation, USA
Thursday, March 17 \| 9:00AM - 11:15AM Developmental Origin of Stem Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 2 of 5 Jason R. Spence, University of Michigan Health System, USA Pluripotent Stem Cell Derived Organoid Models to Study Human Development
Thursday, March 17 \| 9:00AM - 11:15AM Developmental Origin of Stem Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 3 of 5 Atsushi Suzuki, Medical Institute of Bioregulation, Kyushu University, Japan Stem Cell Systems in the Liver
Thursday, March 17 \| 9:00AM - 11:15AM Developmental Origin of Stem Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 4 of 5 Olivia G. Kelly, Viacyte, Inc., USA Stem-Cell Derived, Macroencapsulated Islet Replacement for Type 1 Diabetes
Thursday, March 17 \| 9:00AM - 11:15AM Developmental Origin of Stem Cells This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 5 of 5 Somdutta Mukherjee, University of Pennsylvania, USA Short Talk: Investigating the Role of TBX3 in Endodermal Progenitor Cell Maintenance and Differentiation
Thursday, March 17 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Thursday, March 17 \| 11:15AM - 2:30PM On Own for Lunch
Thursday, March 17 \| 2:30PM - 4:30PM Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu nctions Room: Longs Peak Speaker 1 of 9 * Chris Wright, Vanderbilt University Medical Center, USA
Thursday, March 17 \| 2:30PM - 4:30PM Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu nctions Room: Longs Peak Speaker 2 of 9 Aimee Bastidas Ponce, Helmholtz Zentrum Munich, Germany Analysis of the Role of Synaptotagmin 13 in Pancreatic Beta-cell Function and Islet Architecture
Thursday, March 17 \| 2:30PM - 4:30PM Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu nctions Room: Longs Peak Speaker 3 of 9 Esther Marie Bolanis, Indiana University School of Medicine, USA Posttranslational Modification of the Factor eIF5A is Required for the Adaptive Response of the Islet Beta Cell During Insulin Resistance
Thursday, March 17 \| 2:30PM - 4:30PM Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu nctions Room: Longs Peak Speaker 4 of 9 Gitte Lund Christensen, University of Copenhagen, Denmark Pancreatic beta-cells Dysfunction Induced by Prolonged Exposure to Low Dose IL1beta or Bmp2 is associated with beta-cell De-differentiation
Thursday, March 17 \| 2:30PM - 4:30PM Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu nctions Room: Longs Peak Speaker 5 of 9 Jennifer L. Estall, Institut de Recherches Cliniques de Montréal, Canada Pgc-1 Coactivators in beta-cells are Essential for Glycerolipid Metabolism and Insulin Secretion Coupled to Fatty Acids
Thursday, March 17 \| 2:30PM - 4:30PM Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu nctions Room: Longs Peak Speaker 6 of 9 Amanda M. Ackermann, Children's Hospital of Philadelphia, USA Integration of ATAC-seq and RNA-seq Identifies Human Alpha Cell and Beta Cell Signature Genes
Thursday, March 17 \| 2:30PM - 4:30PM Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu nctions Room: Longs Peak Speaker 7 of 9 Aharon Helman, Harvard University, USA p16Ink4a-induced Senescence of Pancreatic beta-cells Enhances Insulin Secretion
Thursday, March 17 \| 2:30PM - 4:30PM Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu nctions Room: Longs Peak Speaker 8 of 9 Aida Martinez-Sanchez, Imperial College London, UK Disallowance of Acot7 in Beta-cells is Required for Normal Insulin Secretion and Glucose Tolerance
Thursday, March 17 \| 2:30PM - 4:30PM Workshop 3: Novel Insight into Beta-Cell Functions and Dysfu nctions Room: Longs Peak Speaker 9 of 9 Lu Zhu, NIDDK, National Institutes of Health, USA Beta-Arrestin-2 is an Essential Regulator of Pancreatic beta-cell Function
Thursday, March 17 \| 2:30PM - 4:30PM Workshop and Panel Discussion 2: Hurdles to Translation This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 1 of 7 * Martín G. Martín, David Geffen School of Medicine at UCLA, USA
Thursday, March 17 \| 2:30PM - 4:30PM Workshop and Panel Discussion 2: Hurdles to Translation This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 2 of 7 Shinichiro Ogawa, McEwen Centre for Regenerative Medicine, Canada Modeling Cystic Fibrosis Biliary Disease with hPSC-Derived Cholangiocyte
Thursday, March 17 \| 2:30PM - 4:30PM Workshop and Panel Discussion 2: Hurdles to Translation This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 3 of 7 Casey Allison Rimland, Cambridge University, UK Progenitor Cells in the Human Extrahepatic Biliary Tree and Gallbladder
Thursday, March 17 \| 2:30PM - 4:30PM Workshop and Panel Discussion 2: Hurdles to Translation This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 4 of 7 Ken Woo, University of Western Australia, Australia Liver Progenitor Cells Derived from Pluripotent Stem Cells
Thursday, March 17 \| 2:30PM - 4:30PM Workshop and Panel Discussion 2: Hurdles to Translation This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 5 of 7 Christopher Heinen, University of Connecticut Health, USA The DNA Mismatch Repair-Dependent Damage Response in Human Embryonic Stem Cell-Derived Intestinal Organoids
Thursday, March 17 \| 2:30PM - 4:30PM Workshop and Panel Discussion 2: Hurdles to Translation This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 6 of 7 Maelle Lorvellec, University College London, UK Differentiation of human Embryonic Stem Cells and Induced Pluripotent Stem Cells into Hepatocytes-like Cells in a Mouse Decellularized Liver Scaffold
Thursday, March 17 \| 2:30PM - 4:30PM Workshop and Panel Discussion 2: Hurdles to Translation This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 7 of 7 Li-Fang Chu, University of Wisconsin-Madison, USA Single-cell RNA-seq Reveals Novel Regulators of Human Embryonic Stem Cell Differentiation to Definitive Endoderm
Thursday, March 17 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, March 17 \| 5:00PM - 6:45PM Type-1 Diabetes: The Beta-Cell Immune System Interface Room: Longs Peak Speaker 1 of 4 * Miriam Cnop, Universite Libre de Bruxelles, Belgium
Thursday, March 17 \| 5:00PM - 6:45PM Type-1 Diabetes: The Beta-Cell Immune System Interface Room: Longs Peak Speaker 2 of 4 Mark A. Atkinson, University of Florida, USA The Pathogenesis of Human Type 1 Diabetes - A Disease of the Immune System, Beta Cells and Pancreas
Thursday, March 17 \| 5:00PM - 6:45PM Type-1 Diabetes: The Beta-Cell Immune System Interface Room: Longs Peak Speaker 3 of 4 Carla J. Greenbaum, Benaroya Research Institute at Virginia Mason, USA T1D Therapeutic Approaches
Thursday, March 17 \| 5:00PM - 6:45PM Type-1 Diabetes: The Beta-Cell Immune System Interface Room: Longs Peak Speaker 4 of 4 Rene Maehr, University of Massachusetts Medical School, USA Towards a Human Pluripotent Stem Cell-Based Disease Model for Autoimmune Diabetes
Thursday, March 17 \| 5:00PM - 6:45PM Translational and Clinical Applications This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 1 of 4 * Jill L. Carrington, National Institute of Diabetes and Digestive and Kidney Diseases, USA
Thursday, March 17 \| 5:00PM - 6:45PM Translational and Clinical Applications This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 2 of 4 Tsutomu Chiba, Kyoto University, Japan Double Cortin-Like Kinase 1 (Dclk1) Marks PanIN-initiating Cells in Acinar-to-Ductal Metaplasia (ADM)
Thursday, March 17 \| 5:00PM - 6:45PM Translational and Clinical Applications This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 3 of 4 William Proctor, Genentech, Inc., USA Role of PI3Kalpha and mTOR Inhibition in Endoderm Differentiation as a First Step toward Personalized Toxicology
Thursday, March 17 \| 5:00PM - 6:45PM Translational and Clinical Applications This session is from Stem Cells and Regeneration Room: Grays Peak Speaker 4 of 4 Martín G. Martín, David Geffen School of Medicine at UCLA, USA Intestinal Stem Cells - Bench to Bedside, and Future Challenges
Thursday, March 17 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Longs Peak
Thursday, March 17 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) This session is from Stem Cells and Regeneration Room: Grays Peak
Thursday, March 17 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Thursday, March 17 \| 8:00PM - 11:00PM Entertainment Room: Red Cloud/Shavano/Torreys Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, March 17 \| 8:00PM - 11:00PM Cash Bar Room: Red Cloud/Shavano/Torreys
Friday, March 18 \| 10:23AM - 10:23AM Departure *Session Chair †Invited, not yet responded.