Web Desc
Heart Failure: Genetics, Genomics and Epigenetics
joint with Cardiac Development, Regeneration and Repair
Organizer(s): Stuart A. Cook, Christine E. Seidman and Yigal M. Pinto
Date: April 03 - 07, 2016
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by Bayer HealthCare Pharmaceuticals, Pfizer Inc. and Takeda Pharmaceutical Company Limited
For important information on the coronavirus, please click here
Summary of Meeting:
Heart failure (HF) is a worldwide epidemic with treatments costing tens of billions of dollars every year. Despite this investment, HF therapies have limited efficacy in reducing disease progression. Recent insights in fundamental myocyte biology, HF etiologies and pathogenic mechanisms are propelling new strategies to treat and prevent HF. This meeting will explore biologic and technical advances that inform the genetic architecture, molecular pathogenesis and innovative approaches to treat HF. This comes at a time when very large human HF datasets are available and can be interrogated using advanced computational and bioinformatic approaches. Specific aims are to: 1) Consider genes, molecules, signaling pathways and biomarkers involved in systolic and diastolic HF in humans; 2) Explore disease mechanisms underlying HF in model systems; 3) Understand the role of epigenetics, miRNAs and lncRNAs in HF pathogenesis; and 4) Review translational programs in genomic, pharmacologic and cell-based therapeutics to treat HF. The outcomes of this meeting should be far-reaching for basic, translational and clinical communities. The meeting should also provide an excellent training program for junior scientists and serve as a catalyst for collaboration among research, clinical and industrial participants. This meeting is being held in conjunction with the “Cardiac Development, Regeneration and Repair” meeting that provides an outstanding opportunity for joint sessions in genetics, iPSC disease modeling, stem cell therapeutics and epigenetics.
Scholarship Deadline: December 3 2015
Discounted Abstract Deadline: December 3 2015
Abstract Deadline: January 7 2016
Discounted Registration Deadline: February 4 2016
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer HealthCare PharmaceuticalsPfizer Inc.Takeda Pharmaceutical Company Limited
We gratefully acknowledge additional support for this conference from:

American Heart Association's Council on Functional Genomics and Translational Biology
Bethyl Laboratories, Inc.Cytokinetics, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL131204-01
Funding for this conference was made possible (in part) by 1R13HL131204-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 03 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Sunday, April 03 | 6:00PM - 8:00PM
Welcome Mixer
Room: Ballroom Lobby
No registration fees are used to fund alcohol served at this function.

Monday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, April 04 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Ballroom 1

Speaker 1 of 1
James A. Spudich, Stanford University, USA
Mutations to Mechanisms to Therapies

Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
Room: Ballroom 1

Speaker 1 of 7
* Christine E. Seidman, Harvard Medical School, USA

Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
Room: Ballroom 1

Speaker 2 of 7
* Hugh Watkins, University of Oxford, UK

Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
Room: Ballroom 1

Speaker 3 of 7
Frank R. Heinzel, Germany
What We Don't Know?

Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
Room: Ballroom 1

Speaker 4 of 7
Denise Hilfiker-Kleiner, Medizinische Hochschule Hannover, Germany
Molecular Mechanisms Underlying Peripartum Cardiomyopathy

Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
Room: Ballroom 1

Speaker 5 of 7
Robert N. Willette, GlaxoSmithKline, USA
Challenges and Opportunities in Heart Failure Drug Discovery: An Industry Perspective

Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
Room: Ballroom 1

Speaker 6 of 7
Leanne Elizabeth Felkin, Imperial College London, UK
Short Talk: Recovery of Cardiac Function in Cardiomyopathy due to Titin Truncation

Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
Room: Ballroom 1

Speaker 7 of 7
Pu Qin, GlaxoSmithKline, USA
Short Talk: Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress and Improves Survival

Monday, April 04 | 9:00AM - 11:30AM
Cardiac Lineage Commitment and Specification
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 1 of 6
* Christine L. Mummery, Leiden University Medical Center, Netherlands


Monday, April 04 | 9:00AM - 11:30AM
Cardiac Lineage Commitment and Specification
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 2 of 6
Vincent M. Christoffels, Academic Medical Center, Netherlands
T-Box Transcription Factors in Conduction System Lineage Determination


Monday, April 04 | 9:00AM - 11:30AM
Cardiac Lineage Commitment and Specification
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 3 of 6
Benoit G. Bruneau, Gladstone Institutes, USA
Transcriptional Regulation of Heart Development and Chromatin Structure


Monday, April 04 | 9:00AM - 11:30AM
Cardiac Lineage Commitment and Specification
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 4 of 6
Katherine E. Yutzey, Cincinnati Children's Hospital Medical Center, USA
Epicardial-Derived Lineages in Heart Development and Disease


Monday, April 04 | 9:00AM - 11:30AM
Cardiac Lineage Commitment and Specification
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 5 of 6
Alexandre R. Colas, Sanford-Burnham Medical Research Institute, USA
Short Talk: Id1 Is an Evolutionarily Conserved Master Regulator of Cardiogenic Mesoderm Formation


Monday, April 04 | 9:00AM - 11:30AM
Cardiac Lineage Commitment and Specification
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 6 of 6
Daniel M. DeLaughter, Harvard Medical School, USA
Short Talk: Single Cell Transcriptional Atlas of Cardiac Development


Monday, April 04 | 9:40AM - 10:00AM
Coffee Break
Room: Ballroom Lobby


Monday, April 04 | 11:30AM - 2:30PM
On Own for Lunch


Monday, April 04 | 11:30AM - 1:00PM
Poster Setup
Room: Primrose


Monday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
Room: Ballroom 1-3

Speaker 1 of 10
* Norbert Hubner, Max-Delbrück-Centrum für Molekulare Medizin, Germany

Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
Room: Ballroom 1-3

Speaker 2 of 10
* Denise Hilfiker-Kleiner, Medizinische Hochschule Hannover, Germany

Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
Room: Ballroom 1-3

Speaker 3 of 10
Daniel I. Swerdlow, University College London, UK
Heart FailuRe Molecular Epidemiology for Therapeutic TargetS (HERMES) Consortium: Design of a Collaborative Genetic Meta-Analysis Investigating Causal Pathways in Heart Failure

Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
Room: Ballroom 1-3

Speaker 4 of 10
J. Gustav Smith, Lund University, Sweden
Discovery and Initial Characterization of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
Room: Ballroom 1-3

Speaker 5 of 10
Lek Wen Tan, Genome Institute of Singapore, Singapore
Circular RNA Landscape in Human and Mouse Heart

Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
Room: Ballroom 1-3

Speaker 6 of 10
Anthony Cammarato, Johns Hopkins University, USA
Influence of Actin Pseudo-Acetylation on in vivo and in vitro Cardiac Performance

Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
Room: Ballroom 1-3

Speaker 7 of 10
Yasmine Essam Eldin Soliman Aguib, Aswan Heart Centre, Magdi Yacoub Foundation, Egypt
Defining the Genetic Architecture of Cardiomyopathy within the Egyptian Population

Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
Room: Ballroom 1-3

Speaker 8 of 10
Saptarsi M. Haldar, University of California, San Francisco, USA
Therapeutic Targeting of Chromatin-Dependent Signaling in Heart Failure

Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
Room: Ballroom 1-3

Speaker 9 of 10
Selvi Celik, Lund University, Sweden
Atrial Natriuretic Peptide Expression is Negatively Regulated by a Long Noncoding Antisense RNA Transcript (NPPA-AS1) in Human Cardiomyocytes

Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
Room: Ballroom 1-3

Speaker 10 of 10
Rudolf J. Wiesner, University of Cologne, Germany
Mosaic Mitochondrial Respiratory Chain Deficiency Causes Cardiac Arrhythmia during Aging

Monday, April 04 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Tissue and Organs on Chips (Joint)
Room: Ballroom 1-3

Speaker 1 of 5
* Karl Tryggvason, Karolinska Institutet, Sweden

Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Tissue and Organs on Chips (Joint)
Room: Ballroom 1-3

Speaker 2 of 5
Thomas Eschenhagen, University Medical Center Hamburg-Eppendorf, Germany
Dissecting Gene Variant Effects with Tissue Models

Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Tissue and Organs on Chips (Joint)
Room: Ballroom 1-3

Speaker 3 of 5
Christopher S. Chen, Boston University, USA
Mechanoregulation of Form and Function: A Story of Cell Adhesion and the Cytoskeleton

Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Tissue and Organs on Chips (Joint)
Room: Ballroom 1-3

Speaker 4 of 5
Eric N. Olson, University of Texas Southwestern Medical Center, USA
Myoediting: Correction of DMD by CRISPR/Cas9 Gene Editing

Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Tissue and Organs on Chips (Joint)
Room: Ballroom 1-3

Speaker 5 of 5
Kevin Beussman, University of Washington, USA
Short Talk: Intracellular Assessment of the Maturation of Excitation-Contraction Coupling in Human Stem Cell-Derived Cardiomyocytes

Monday, April 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Monday, April 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Primrose


Tuesday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What’s New?
Room: Ballroom 1

Speaker 1 of 7
* Norbert Hubner, Max-Delbrück-Centrum für Molekulare Medizin, Germany

Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What’s New?
Room: Ballroom 1

Speaker 2 of 7
* Carolyn Ho, Brigham and Women's Hospital, USA

Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What’s New?
Room: Ballroom 1

Speaker 3 of 7
Stuart Cook, Duke-NUS, Singapore
Disease Mechanisms in Titin Cardiomyopathy

Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What’s New?
Room: Ballroom 1

Speaker 4 of 7
Christine E. Seidman, Harvard Medical School, USA
Genetic (and Other) Antidotes for Cardiomyopathy

Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What’s New?
Room: Ballroom 1

Speaker 5 of 7
Richard L. Moss, University of Wisconsin, Madison, USA
Modulation of Sarcomeres via MYBPC3

Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What’s New?
Room: Ballroom 1

Speaker 6 of 7
Leslie A. Leinwand, University of Colorado Boulder, USA
Myosin Myopathies: Pathogenesis and Potential Therapeutics

Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What’s New?
Room: Ballroom 1

Speaker 7 of 7
Hugh Watkins, University of Oxford, UK
Sequencing Sarcomeric (and Other Genes) in Cardiomyopathy

Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 1 of 7
* Benoit G. Bruneau, Gladstone Institutes, USA


Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 2 of 7
Jonathan A. Epstein, University of Pennsylvania, USA
Nuclear Architecture and Cardiac Development


Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 3 of 7
Eldad Tzahor, Weizmann Institute of Science, Israel
Novel Insights into Cardiac Regeneration


Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 4 of 7
Kristy Red-Horse, Stanford University, USA
Growth and Patterning of Coronary Arteries


Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 5 of 7
Neil C. Chi, University of California, San Diego, USA
Cellular and Genetic Dissection of Cardiovascular Development and Regeneration


Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 6 of 7
Ignacio Flores, Centro Nacional de Investigaciones Cardiovasculares, Spain
Short Talk: Telomerase is Essential for Zebrafish Heart Regeneration


Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 7 of 7
Tilde Eskildsen, Odense University Hospital, Denmark
Short Talk: Defining the Earliest Step of Cardiovascular Development Using CRISPR Genome Editing Technology


Tuesday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, April 05 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, April 05 | 11:15AM - 1:00PM
Poster Setup
Room: Primrose


Tuesday, April 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Tuesday, April 05 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, April 05 | 5:00PM - 7:00PM
Systems Dissection of Cardiac Failure
Room: Ballroom 1

Speaker 1 of 3
* Yigal M. Pinto, University of Amsterdam, Netherlands

Tuesday, April 05 | 5:00PM - 7:00PM
Systems Dissection of Cardiac Failure
Room: Ballroom 1

Speaker 2 of 3
Norbert Hubner, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Dissecting the Genetic Basis of Translational Regulation in Heart Failure

Tuesday, April 05 | 5:00PM - 7:00PM
Systems Dissection of Cardiac Failure
Room: Ballroom 1

Speaker 3 of 3
Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
Towards a Structural Basis of Complex Disorders of the Heart: Calcium Leak and Mitochondria



Tuesday, April 05 | 5:00PM - 7:00PM
Differentiation and Characterization of Cardiomyocytes from
Pluripotent Stem Cells
This session is from Cardiac Development

Room: Ballroom 2-3

Speaker 1 of 5
* Martina Brueckner, Yale University School of Medicine, USA


Tuesday, April 05 | 5:00PM - 7:00PM
Differentiation and Characterization of Cardiomyocytes from
Pluripotent Stem Cells
This session is from Cardiac Development

Room: Ballroom 2-3

Speaker 2 of 5
David A. Elliott, Murdoch Childrens Research Institute, Australia
Generating Cellular Diversity during Human Cardiovascular Development


Tuesday, April 05 | 5:00PM - 7:00PM
Differentiation and Characterization of Cardiomyocytes from
Pluripotent Stem Cells
This session is from Cardiac Development

Room: Ballroom 2-3

Speaker 3 of 5
Bernd K. Fleischmann, Bonn University, Germany
Assessing Plasticity of Cardiomyocytes Using Pluripotent ES-Cell and Mouse Models


Tuesday, April 05 | 5:00PM - 7:00PM
Differentiation and Characterization of Cardiomyocytes from
Pluripotent Stem Cells
This session is from Cardiac Development

Room: Ballroom 2-3

Speaker 4 of 5
Godfrey Smith, University of Glasgow, UK
The Pharmacology of iPS-Derived Cardiomyocytes


Tuesday, April 05 | 5:00PM - 7:00PM
Differentiation and Characterization of Cardiomyocytes from
Pluripotent Stem Cells
This session is from Cardiac Development

Room: Ballroom 2-3

Speaker 5 of 5
Sanjay Sinha, University of Cambridge, UK
Short Talk: Human Pluripotent Stem Cell-Derived Epicardium Promotes Cardiomyocyte Maturation and Contraction in Tissue-Engineered Cardiac Constructs


Tuesday, April 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Tuesday, April 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Primrose


Wednesday, April 06 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
Room: Ballroom 1

Speaker 1 of 8
* Leslie A. Leinwand, University of Colorado Boulder, USA

Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
Room: Ballroom 1

Speaker 2 of 8
* Gerald W. Dorn, II, Washington University School of Medicine, USA

Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
Room: Ballroom 1

Speaker 3 of 8
Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA
Interplay of Proteotoxicity, Heart Failure and Autophagy

Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
Room: Ballroom 1

Speaker 4 of 8
Richard T. Lee, Harvard University, USA
Systemic Factors and Cardiac Aging

Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
Room: Ballroom 1

Speaker 5 of 8
Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
Genetic Lineage Tracing Defines Myofibroblast Origin and Function in the Injured Heart

Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
Room: Ballroom 1

Speaker 6 of 8
Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Autophagy and Heart Disease

Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
Room: Ballroom 1

Speaker 7 of 8
Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Short Talk: Preserving Heart Function despite Obesity, Aging and Parental Diet

Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
Room: Ballroom 1

Speaker 8 of 8
Eleonora Adami, Max Delbrück Center for Molecular Medicine, MDC, Germany
Short Talk: Ribo-Seq Provides a Genome-Wide View of Translational Control in the Diseased Human and Rat Heart

Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease
This session is from Cardiac Development

Room: Ballroom 2-3

Speaker 1 of 7
* Stacey L. Rentschler, Washington University School of Medicine, USA


Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease
This session is from Cardiac Development

Room: Ballroom 2-3

Speaker 2 of 7
Joseph C. Wu, Stanford University School of Medicine, USA
Cardiac iPSCs for Disease Modeling and Drug Discovery


Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease
This session is from Cardiac Development

Room: Ballroom 2-3

Speaker 3 of 7
Lior Gepstein, Technion-Israel Institute of Technology, Israel
iPS Modeling of Cardiac Disease: Arrhythmias and Heart Failure


Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease
This session is from Cardiac Development

Room: Ballroom 2-3

Speaker 4 of 7
Christine L. Mummery, Leiden University Medical Center, Netherlands
Human iPS Cell Models of Heart and Blood Vessel Disease


Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease
This session is from Cardiac Development

Room: Ballroom 2-3

Speaker 5 of 7
Kiran Musunuru, University of Pennsylvania, USA
Genome Editing of Human Pluripotent Stem Cells to Generate Human Cellular Disease Models


Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease
This session is from Cardiac Development

Room: Ballroom 2-3

Speaker 6 of 7
Zhen Ma, University of California, Berkeley, USA
Short Talk: Biomaterial-Guided Isogenic iPS Disease Modeling of Hypertrophic Cardiomyopathy


Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease
This session is from Cardiac Development

Room: Ballroom 2-3

Speaker 7 of 7
Yuta Yamamoto, Kyoto University, Japan
Short Talk: Modeling of Long-QT Syndrome Associated with a Calmodulin Mutation using Human Induced Pluripotent Stem Cells


Wednesday, April 06 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Wednesday, April 06 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, April 06 | 11:15AM - 1:00PM
Poster Setup
Room: Primrose


Wednesday, April 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Wednesday, April 06 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n

Room: Ballroom 1

Speaker 1 of 7
* Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA

Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n

Room: Ballroom 1

Speaker 2 of 7
* Stefan Engelhardt, Technical University of Munich, Germany

Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n

Room: Ballroom 1

Speaker 3 of 7
Wolfgang A. Linke, University of Munster, Germany
Titin Elasticity Impacts Diastolic and Systolic Function

Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n

Room: Ballroom 1

Speaker 4 of 7
David Warshaw, University of Vermont, USA
Molecular Mechanics of MYBPC3

Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n

Room: Ballroom 1

Speaker 5 of 7
Gerald W. Dorn, II, Washington University School of Medicine, USA
Mitochondrial Triage: Dynamism Determines Quality Control

Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n

Room: Ballroom 1

Speaker 6 of 7
Nina de Groot, University of Amsterdam, Netherlands
Short Talk: Rbm24 Influences the force-Ca2+ Relation in Heart Muscle

Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n

Room: Ballroom 1

Speaker 7 of 7
Ryan L. Boudreau, University of Iowa, USA
Short Talk: The Cardiac microRNA-target Interactome Reveals a Novel miR-24:SCN5A:SNP Interaction Associating with Non-Arrhythmic Death in Heart Failure

Wednesday, April 06 | 5:00PM - 7:15PM
Vascular Development and Disease
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 1 of 5
Anne C. Eichmann, Yale University School of Medicine, USA
Signalling in Vascular Development and Function


Wednesday, April 06 | 5:00PM - 7:15PM
Vascular Development and Disease
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 2 of 5
Zoltan P. Arany, University of Pennsylvania, USA
Vascular Metabolism and Disease


Wednesday, April 06 | 5:00PM - 7:15PM
Vascular Development and Disease
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 3 of 5
Stefanie Dimmeler, University of Frankfurt, Germany
Non-Coding RNAs in Cardiovascular Repair


Wednesday, April 06 | 5:00PM - 7:15PM
Vascular Development and Disease
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 4 of 5
Alexandria Afonso, McMaster University, Canada
Short Talk: Modeling Genetic Determinants of Early-Onset Coronary Artery Disease using Patient-Derived Induced Pluripotent Stem Cells


Wednesday, April 06 | 5:00PM - 7:15PM
Vascular Development and Disease
This session is from Cardiac Development
Room: Ballroom 2-3

Speaker 5 of 5
Naoko Koyano-Nakagawa, University of Minnesota, USA
Short Talk: Feedback Mechanisms Regulate Ets variant 2 (Etv2) Gene Expression and Hematoendothelial Lineages


Wednesday, April 06 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Wednesday, April 06 | 7:30PM - 10:00PM
Poster Session 3
Room: Primrose


Thursday, April 07 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 1 of 7
* Joseph C. Wu, Stanford University School of Medicine, USA

Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 2 of 7
Paul R. Riley, University of Oxford, UK
Developmental Programming of the Cardiac Lymphatics towards Heart Repair

Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 3 of 7
Kenneth D. Poss, Duke University Medical Center, USA
Endogenous Heart Regeneration Programs

Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 4 of 7
Charles E. Murry, University of Washington, USA
Cardiogenesis with Human Pluripotent Stem Cells

Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 5 of 7
Karl Tryggvason, Karolinska Institutet, Sweden
Using Laminins to Generate Therapeutic Cardiomyocytes from hES Cells

Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 6 of 7
Anna Blice-Baum, Johns Hopkins University, USA
Short Talk: Titered FOXO Overexpression Maintains Cardiac Proteostasis and Ameliorates Age-Associated Functional Decline

Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 7 of 7
Palmer Yu, Gladstone Institutes, USA
Short Talk: Regeneration of Cardiomyocytes in vivo Using Human Cardiac Reprogramming Factors in a Pig Model

Thursday, April 07 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Thursday, April 07 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, April 07 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, April 07 | 5:00PM - 6:45PM
Epigenetics and miRNAs: Muscle Failure and Arrhythmia Predis
position

Room: Ballroom 1

Speaker 1 of 5
* Esther E. Creemers, Academic Medical Center, Netherlands

Thursday, April 07 | 5:00PM - 6:45PM
Epigenetics and miRNAs: Muscle Failure and Arrhythmia Predis
position

Room: Ballroom 1

Speaker 2 of 5
* Joseph A. Hill, University of Texas Southwestern Medical Center, USA

Thursday, April 07 | 5:00PM - 6:45PM
Epigenetics and miRNAs: Muscle Failure and Arrhythmia Predis
position

Room: Ballroom 1

Speaker 3 of 5
Stefan Engelhardt, Technical University of Munich, Germany
MiRNAs from Non-Muscle Cells

Thursday, April 07 | 5:00PM - 6:45PM
Epigenetics and miRNAs: Muscle Failure and Arrhythmia Predis
position

Room: Ballroom 1

Speaker 4 of 5
Roger Foo, Genome Institute of Singapore, Singapore
What Single Cell Genomics Can Tell Us About Heart Failure

Thursday, April 07 | 5:00PM - 6:45PM
Epigenetics and miRNAs: Muscle Failure and Arrhythmia Predis
position

Room: Ballroom 1

Speaker 5 of 5
Yigal M. Pinto, University of Amsterdam, Netherlands
Role of Cardiac Specific RNA Binding Proteins in Regulating miRNA Function

Thursday, April 07 | 5:00PM - 6:45PM
Cardiomyocyte Maturation, Proliferation and Cardiac Remodeli
ng
This session is from Cardiac Development

Room: Ballroom 2

Speaker 1 of 4
* Bernd K. Fleischmann, Bonn University, Germany


Thursday, April 07 | 5:00PM - 6:45PM
Cardiomyocyte Maturation, Proliferation and Cardiac Remodeli
ng
This session is from Cardiac Development

Room: Ballroom 2

Speaker 2 of 4
Anthony J. Muslin, Tectonic Therapeutic, Inc., USA
Signal Transduction Pathways Related to Cardiac Hypertrophy


Thursday, April 07 | 5:00PM - 6:45PM
Cardiomyocyte Maturation, Proliferation and Cardiac Remodeli
ng
This session is from Cardiac Development

Room: Ballroom 2

Speaker 3 of 4
Jose Luis de la Pompa, Centro Nacional de Investigaciones Cardiovasculares, Spain
Notch Signaling in Ventricular Chamber Development and Disease


Thursday, April 07 | 5:00PM - 6:45PM
Cardiomyocyte Maturation, Proliferation and Cardiac Remodeli
ng
This session is from Cardiac Development

Room: Ballroom 2

Speaker 4 of 4
Thomas Braun, Germany
The Role of Dedifferentiated Cardiomyocytes in the Diseased Myocardium


Thursday, April 07 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Ballroom 1


Thursday, April 07 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Cardiac Development
Room: Ballroom 2


Thursday, April 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 2-3
No registration fees are used to fund alcohol served at this function.

Thursday, April 07 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2-3
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, April 07 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 2-3


Friday, April 08 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.