Web Desc
Cardiac Development, Regeneration and Repair
joint with Heart Failure: Genetics, Genomics and Epigenetics
Organizer(s): Christine L. Mummery, Joseph C. Wu and Jonathan A. Epstein
Date: April 03 - 07, 2016
Location: Snowbird Resort, Snowbird, UT, USA
Supported by the Directors' Fund
Summary of Meeting:
Cardiovascular disease is the leading cause of death worldwide. There is increasing evidence that developmental mechanisms regulating cardiac and vascular cell lineage differentiation and organogenesis contribute to cardiovascular disease in childhood and throughout life and could be leveraged to reduce cardiac damage and mediate repair or regeneration once damage has occurred. This meeting will emphasize shared molecular mechanisms in cardiovascular development, regeneration and disease and consider how patient-relevant pluripotent stem cell models can contribute to understanding human disease states. Discussion of new bioassays, methods of genetic modification and bioengineering in animals and stem cells will complement these sessions, with the aim of facilitating translational approaches in cardiovascular regeneration, repair and disease modeling. Specific aims are to: 1) Consider animal models for understanding cardiovascular cell lineage commitment, differentiation and proliferation; 2) Explore how this can be applied to creating new stem cell-based models that result in mature cardiovascular derivatives and assays for disease target discovery; and 3) Explore therapeutic potential for cardiovascular repair and regeneration mechanisms in clinical practice. Overall, the goal of the meeting is to bring together world-class speakers and researchers with expertise in cardiac embryology, molecular biology, stem cell biology, human genetics and tissue engineering to facilitate new scientific directions and therapeutic approaches in the management and treatment of cardiovascular disease.
Scholarship Deadline: December 3 2015
Discounted Abstract Deadline: December 3 2015
Abstract Deadline: January 7 2016
Discounted Registration Deadline: February 4 2016
We gratefully acknowledge additional support for this conference from:
IlluminaMarch of Dimes Foundation, Grant No. 4-FY15-442
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL131055-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 03 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Sunday, April 03 | 6:00PM - 8:00PM
Welcome Mixer
Room: Ballroom Lobby
No registration fees are used to fund alcohol served at this function.

Monday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, April 04 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Ballroom 2-3

Speaker 1 of 1
Peter W. Reddien, Whitehead Institute, USA
The Role of Muscle Cells in Directing Regeneration in Planarians

Monday, April 04 | 9:00AM - 11:30AM
Cardiac Lineage Commitment and Specification
Room: Ballroom 2-3

Speaker 1 of 6
* Christine L. Mummery, Leiden University Medical Center, Netherlands

Monday, April 04 | 9:00AM - 11:30AM
Cardiac Lineage Commitment and Specification
Room: Ballroom 2-3

Speaker 2 of 6
Vincent M. Christoffels, Academic Medical Center, Netherlands
T-Box Transcription Factors in Conduction System Lineage Determination

Monday, April 04 | 9:00AM - 11:30AM
Cardiac Lineage Commitment and Specification
Room: Ballroom 2-3

Speaker 3 of 6
Benoit G. Bruneau, Gladstone Institutes, USA
Transcriptional Regulation of Heart Development and Chromatin Structure

Monday, April 04 | 9:00AM - 11:30AM
Cardiac Lineage Commitment and Specification
Room: Ballroom 2-3

Speaker 4 of 6
Katherine E. Yutzey, Cincinnati Children's Hospital Medical Center, USA
Epicardial-Derived Lineages in Heart Development and Disease

Monday, April 04 | 9:00AM - 11:30AM
Cardiac Lineage Commitment and Specification
Room: Ballroom 2-3

Speaker 5 of 6
Alexandre R. Colas, Sanford-Burnham Medical Research Institute, USA
Short Talk: Id1 Is an Evolutionarily Conserved Master Regulator of Cardiogenic Mesoderm Formation

Monday, April 04 | 9:00AM - 11:30AM
Cardiac Lineage Commitment and Specification
Room: Ballroom 2-3

Speaker 6 of 6
Daniel M. DeLaughter, Harvard Medical School, USA
Short Talk: Single Cell Transcriptional Atlas of Cardiac Development

Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
This session is from Heart Failure
Room: Ballroom 1

Speaker 1 of 7
* Christine E. Seidman, Harvard Medical School, USA


Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
This session is from Heart Failure
Room: Ballroom 1

Speaker 2 of 7
* Hugh Watkins, University of Oxford, UK


Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
This session is from Heart Failure
Room: Ballroom 1

Speaker 3 of 7
Frank R. Heinzel, Germany
What We Don't Know?


Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
This session is from Heart Failure
Room: Ballroom 1

Speaker 4 of 7
Denise Hilfiker-Kleiner, Medizinische Hochschule Hannover, Germany
Molecular Mechanisms Underlying Peripartum Cardiomyopathy


Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
This session is from Heart Failure
Room: Ballroom 1

Speaker 5 of 7
Robert N. Willette, GlaxoSmithKline, USA
Challenges and Opportunities in Heart Failure Drug Discovery: An Industry Perspective


Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
This session is from Heart Failure
Room: Ballroom 1

Speaker 6 of 7
Leanne Elizabeth Felkin, Imperial College London, UK
Short Talk: Recovery of Cardiac Function in Cardiomyopathy due to Titin Truncation


Monday, April 04 | 9:00AM - 11:30AM
Heart Failure 2016: Syndromes, Mechanisms and Treatments
This session is from Heart Failure
Room: Ballroom 1

Speaker 7 of 7
Pu Qin, GlaxoSmithKline, USA
Short Talk: Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress and Improves Survival


Monday, April 04 | 9:40AM - 10:00AM
Coffee Break
Room: Ballroom Lobby


Monday, April 04 | 11:30AM - 5:00PM
On Own for Lunch


Monday, April 04 | 11:30AM - 1:00PM
Poster Setup
Room: Primrose


Monday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
This session is from Heart Failure
Room: Ballroom 1-3

Speaker 1 of 10
* Norbert Hubner, Max-Delbrück-Centrum für Molekulare Medizin, Germany


Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
This session is from Heart Failure
Room: Ballroom 1-3

Speaker 2 of 10
* Denise Hilfiker-Kleiner, Medizinische Hochschule Hannover, Germany


Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
This session is from Heart Failure
Room: Ballroom 1-3

Speaker 3 of 10
Daniel I. Swerdlow, University College London, UK
Heart FailuRe Molecular Epidemiology for Therapeutic TargetS (HERMES) Consortium: Design of a Collaborative Genetic Meta-Analysis Investigating Causal Pathways in Heart Failure


Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
This session is from Heart Failure
Room: Ballroom 1-3

Speaker 4 of 10
J. Gustav Smith, Lund University, Sweden
Discovery and Initial Characterization of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure


Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
This session is from Heart Failure
Room: Ballroom 1-3

Speaker 5 of 10
Lek Wen Tan, Genome Institute of Singapore, Singapore
Circular RNA Landscape in Human and Mouse Heart


Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
This session is from Heart Failure
Room: Ballroom 1-3

Speaker 6 of 10
Anthony Cammarato, Johns Hopkins University, USA
Influence of Actin Pseudo-Acetylation on in vivo and in vitro Cardiac Performance


Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
This session is from Heart Failure
Room: Ballroom 1-3

Speaker 7 of 10
Yasmine Essam Eldin Soliman Aguib, Aswan Heart Centre, Magdi Yacoub Foundation, Egypt
Defining the Genetic Architecture of Cardiomyopathy within the Egyptian Population


Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
This session is from Heart Failure
Room: Ballroom 1-3

Speaker 8 of 10
Saptarsi M. Haldar, University of California, San Francisco, USA
Therapeutic Targeting of Chromatin-Dependent Signaling in Heart Failure


Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
This session is from Heart Failure
Room: Ballroom 1-3

Speaker 9 of 10
Selvi Celik, Lund University, Sweden
Atrial Natriuretic Peptide Expression is Negatively Regulated by a Long Noncoding Antisense RNA Transcript (NPPA-AS1) in Human Cardiomyocytes


Monday, April 04 | 2:30PM - 4:30PM
Workshop and Panel 1: Molecular Etiology of Heart Failure
This session is from Heart Failure
Room: Ballroom 1-3

Speaker 10 of 10
Rudolf J. Wiesner, University of Cologne, Germany
Mosaic Mitochondrial Respiratory Chain Deficiency Causes Cardiac Arrhythmia during Aging


Monday, April 04 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Tissue and Organs on Chips (Joint)
Room: Ballroom 1-3

Speaker 1 of 5
* Karl Tryggvason, Karolinska Institutet, Sweden

Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Tissue and Organs on Chips (Joint)
Room: Ballroom 1-3

Speaker 2 of 5
Thomas Eschenhagen, University Medical Center Hamburg-Eppendorf, Germany
Dissecting Gene Variant Effects with Tissue Models

Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Tissue and Organs on Chips (Joint)
Room: Ballroom 1-3

Speaker 3 of 5
Christopher S. Chen, Boston University, USA
Mechanoregulation of Form and Function: A Story of Cell Adhesion and the Cytoskeleton

Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Tissue and Organs on Chips (Joint)
Room: Ballroom 1-3

Speaker 4 of 5
Eric N. Olson, University of Texas Southwestern Medical Center, USA
Myoediting: Correction of DMD by CRISPR/Cas9 Gene Editing

Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Tissue and Organs on Chips (Joint)
Room: Ballroom 1-3

Speaker 5 of 5
Kevin Beussman, University of Washington, USA
Short Talk: Intracellular Assessment of the Maturation of Excitation-Contraction Coupling in Human Stem Cell-Derived Cardiomyocytes

Monday, April 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Monday, April 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Primrose


Tuesday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
Room: Ballroom 2-3

Speaker 1 of 7
* Benoit G. Bruneau, Gladstone Institutes, USA

Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
Room: Ballroom 2-3

Speaker 2 of 7
Jonathan A. Epstein, University of Pennsylvania, USA
Nuclear Architecture and Cardiac Development

Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
Room: Ballroom 2-3

Speaker 3 of 7
Eldad Tzahor, Weizmann Institute of Science, Israel
Novel Insights into Cardiac Regeneration

Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
Room: Ballroom 2-3

Speaker 4 of 7
Kristy Red-Horse, Stanford University, USA
Growth and Patterning of Coronary Arteries

Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
Room: Ballroom 2-3

Speaker 5 of 7
Neil C. Chi, University of California, San Diego, USA
Cellular and Genetic Dissection of Cardiovascular Development and Regeneration

Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
Room: Ballroom 2-3

Speaker 6 of 7
Ignacio Flores, Centro Nacional de Investigaciones Cardiovasculares, Spain
Short Talk: Telomerase is Essential for Zebrafish Heart Regeneration

Tuesday, April 05 | 8:00AM - 11:15AM
Cardiac Morphogenesis and Regeneration
Room: Ballroom 2-3

Speaker 7 of 7
Tilde Eskildsen, Odense University Hospital, Denmark
Short Talk: Defining the Earliest Step of Cardiovascular Development Using CRISPR Genome Editing Technology

Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What's New?
This session is from Heart Failure
Room: Ballroom 1

Speaker 1 of 7
* Norbert Hubner, Max-Delbrück-Centrum für Molekulare Medizin, Germany


Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What's New?
This session is from Heart Failure
Room: Ballroom 1

Speaker 2 of 7
* Carolyn Ho, Brigham and Women's Hospital, USA


Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What's New?
This session is from Heart Failure
Room: Ballroom 1

Speaker 3 of 7
Stuart Cook, Duke-NUS, Singapore
Disease Mechanisms in Titin Cardiomyopathy


Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What's New?
This session is from Heart Failure
Room: Ballroom 1

Speaker 4 of 7
Christine E. Seidman, Harvard Medical School, USA
Genetic (and Other) Antidotes for Cardiomyopathy


Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What's New?
This session is from Heart Failure
Room: Ballroom 1

Speaker 5 of 7
Richard L. Moss, University of Wisconsin, Madison, USA
Modulation of Sarcomeres via MYBPC3


Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What's New?
This session is from Heart Failure
Room: Ballroom 1

Speaker 6 of 7
Leslie A. Leinwand, University of Colorado Boulder, USA
Myosin Myopathies: Pathogenesis and Potential Therapeutics


Tuesday, April 05 | 8:00AM - 11:15AM
Sarcomere Genetics: So What's New?
This session is from Heart Failure
Room: Ballroom 1

Speaker 7 of 7
Hugh Watkins, University of Oxford, UK
Sequencing Sarcomeric (and Other Genes) in Cardiomyopathy


Tuesday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, April 05 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, April 05 | 11:15AM - 1:00PM
Poster Setup
Room: Primrose


Tuesday, April 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Tuesday, April 05 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, April 05 | 5:00PM - 7:00PM
Differentiation and Characterization of Cardiomyocytes from
Pluripotent Stem Cells

Room: Ballroom 2-3

Speaker 1 of 5
* Martina Brueckner, Yale University School of Medicine, USA

Tuesday, April 05 | 5:00PM - 7:00PM
Differentiation and Characterization of Cardiomyocytes from
Pluripotent Stem Cells

Room: Ballroom 2-3

Speaker 2 of 5
David A. Elliott, Murdoch Childrens Research Institute, Australia
Generating Cellular Diversity during Human Cardiovascular Development

Tuesday, April 05 | 5:00PM - 7:00PM
Differentiation and Characterization of Cardiomyocytes from
Pluripotent Stem Cells

Room: Ballroom 2-3

Speaker 3 of 5
Bernd K. Fleischmann, Bonn University, Germany
Assessing Plasticity of Cardiomyocytes Using Pluripotent ES-Cell and Mouse Models

Tuesday, April 05 | 5:00PM - 7:00PM
Differentiation and Characterization of Cardiomyocytes from
Pluripotent Stem Cells

Room: Ballroom 2-3

Speaker 4 of 5
Godfrey Smith, University of Glasgow, UK
The Pharmacology of iPS-Derived Cardiomyocytes

Tuesday, April 05 | 5:00PM - 7:00PM
Differentiation and Characterization of Cardiomyocytes from
Pluripotent Stem Cells

Room: Ballroom 2-3

Speaker 5 of 5
Sanjay Sinha, University of Cambridge, UK
Short Talk: Human Pluripotent Stem Cell-Derived Epicardium Promotes Cardiomyocyte Maturation and Contraction in Tissue-Engineered Cardiac Constructs

Tuesday, April 05 | 5:00PM - 7:00PM
Systems Dissection of Cardiac Failure
This session is from Heart Failure
Room: Ballroom 1

Speaker 1 of 3
* Yigal M. Pinto, University of Amsterdam, Netherlands


Tuesday, April 05 | 5:00PM - 7:00PM
Systems Dissection of Cardiac Failure
This session is from Heart Failure
Room: Ballroom 1

Speaker 2 of 3
Norbert Hubner, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Dissecting the Genetic Basis of Translational Regulation in Heart Failure


Tuesday, April 05 | 5:00PM - 7:00PM
Systems Dissection of Cardiac Failure
This session is from Heart Failure
Room: Ballroom 1

Speaker 3 of 3
Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
Towards a Structural Basis of Complex Disorders of the Heart: Calcium Leak and Mitochondria



Tuesday, April 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Tuesday, April 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Primrose


Wednesday, April 06 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease

Room: Ballroom 2-3

Speaker 1 of 7
* Stacey L. Rentschler, Washington University School of Medicine, USA

Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease

Room: Ballroom 2-3

Speaker 2 of 7
Joseph C. Wu, Stanford University School of Medicine, USA
Cardiac iPSCs for Disease Modeling and Drug Discovery

Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease

Room: Ballroom 2-3

Speaker 3 of 7
Lior Gepstein, Technion-Israel Institute of Technology, Israel
iPS Modeling of Cardiac Disease: Arrhythmias and Heart Failure

Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease

Room: Ballroom 2-3

Speaker 4 of 7
Christine L. Mummery, Leiden University Medical Center, Netherlands
Human iPS Cell Models of Heart and Blood Vessel Disease

Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease

Room: Ballroom 2-3

Speaker 5 of 7
Kiran Musunuru, University of Pennsylvania, USA
Genome Editing of Human Pluripotent Stem Cells to Generate Human Cellular Disease Models

Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease

Room: Ballroom 2-3

Speaker 6 of 7
Zhen Ma, University of California, Berkeley, USA
Short Talk: Biomaterial-Guided Isogenic iPS Disease Modeling of Hypertrophic Cardiomyopathy

Wednesday, April 06 | 8:00AM - 11:15AM
Human Pluripotent Stem Cells as Models of Cardiovascular Dis
ease

Room: Ballroom 2-3

Speaker 7 of 7
Yuta Yamamoto, Kyoto University, Japan
Short Talk: Modeling of Long-QT Syndrome Associated with a Calmodulin Mutation using Human Induced Pluripotent Stem Cells

Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
This session is from Heart Failure
Room: Ballroom 1

Speaker 1 of 8
* Leslie A. Leinwand, University of Colorado Boulder, USA


Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
This session is from Heart Failure
Room: Ballroom 1

Speaker 2 of 8
* Gerald W. Dorn, II, Washington University School of Medicine, USA


Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
This session is from Heart Failure
Room: Ballroom 1

Speaker 3 of 8
Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA
Interplay of Proteotoxicity, Heart Failure and Autophagy


Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
This session is from Heart Failure
Room: Ballroom 1

Speaker 4 of 8
Richard T. Lee, Harvard University, USA
Systemic Factors and Cardiac Aging


Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
This session is from Heart Failure
Room: Ballroom 1

Speaker 5 of 8
Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
Genetic Lineage Tracing Defines Myofibroblast Origin and Function in the Injured Heart


Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
This session is from Heart Failure
Room: Ballroom 1

Speaker 6 of 8
Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Autophagy and Heart Disease


Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
This session is from Heart Failure
Room: Ballroom 1

Speaker 7 of 8
Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Short Talk: Preserving Heart Function despite Obesity, Aging and Parental Diet


Wednesday, April 06 | 8:00AM - 11:15AM
Aging Hearts
This session is from Heart Failure
Room: Ballroom 1

Speaker 8 of 8
Eleonora Adami, Max Delbrück Center for Molecular Medicine, MDC, Germany
Short Talk: Ribo-Seq Provides a Genome-Wide View of Translational Control in the Diseased Human and Rat Heart


Wednesday, April 06 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Wednesday, April 06 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, April 06 | 11:15AM - 1:00PM
Poster Setup
Room: Primrose


Wednesday, April 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Primrose


Wednesday, April 06 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, April 06 | 5:00PM - 7:15PM
Vascular Development and Disease
Room: Ballroom 2-3

Speaker 1 of 5
Anne C. Eichmann, Yale University School of Medicine, USA
Signalling in Vascular Development and Function

Wednesday, April 06 | 5:00PM - 7:15PM
Vascular Development and Disease
Room: Ballroom 2-3

Speaker 2 of 5
Zoltan P. Arany, University of Pennsylvania, USA
Vascular Metabolism and Disease

Wednesday, April 06 | 5:00PM - 7:15PM
Vascular Development and Disease
Room: Ballroom 2-3

Speaker 3 of 5
Stefanie Dimmeler, University of Frankfurt, Germany
Non-Coding RNAs in Cardiovascular Repair

Wednesday, April 06 | 5:00PM - 7:15PM
Vascular Development and Disease
Room: Ballroom 2-3

Speaker 4 of 5
Alexandria Afonso, McMaster University, Canada
Short Talk: Modeling Genetic Determinants of Early-Onset Coronary Artery Disease using Patient-Derived Induced Pluripotent Stem Cells

Wednesday, April 06 | 5:00PM - 7:15PM
Vascular Development and Disease
Room: Ballroom 2-3

Speaker 5 of 5
Naoko Koyano-Nakagawa, University of Minnesota, USA
Short Talk: Feedback Mechanisms Regulate Ets variant 2 (Etv2) Gene Expression and Hematoendothelial Lineages

Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n
This session is from Heart Failure

Room: Ballroom 1

Speaker 1 of 7
* Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA


Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n
This session is from Heart Failure

Room: Ballroom 1

Speaker 2 of 7
* Stefan Engelhardt, Technical University of Munich, Germany


Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n
This session is from Heart Failure

Room: Ballroom 1

Speaker 3 of 7
Wolfgang A. Linke, University of Munster, Germany
Titin Elasticity Impacts Diastolic and Systolic Function


Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n
This session is from Heart Failure

Room: Ballroom 1

Speaker 4 of 7
David Warshaw, University of Vermont, USA
Molecular Mechanics of MYBPC3


Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n
This session is from Heart Failure

Room: Ballroom 1

Speaker 5 of 7
Gerald W. Dorn, II, Washington University School of Medicine, USA
Mitochondrial Triage: Dynamism Determines Quality Control


Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n
This session is from Heart Failure

Room: Ballroom 1

Speaker 6 of 7
Nina de Groot, University of Amsterdam, Netherlands
Short Talk: Rbm24 Influences the force-Ca2+ Relation in Heart Muscle


Wednesday, April 06 | 5:00PM - 7:15PM
Molecular Aspects of Muscle Cell Contractility and Relaxatio
n
This session is from Heart Failure

Room: Ballroom 1

Speaker 7 of 7
Ryan L. Boudreau, University of Iowa, USA
Short Talk: The Cardiac microRNA-target Interactome Reveals a Novel miR-24:SCN5A:SNP Interaction Associating with Non-Arrhythmic Death in Heart Failure


Wednesday, April 06 | 7:15PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Wednesday, April 06 | 7:30PM - 10:00PM
Poster Session 3
Room: Primrose


Thursday, April 07 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 1 of 7
* Joseph C. Wu, Stanford University School of Medicine, USA

Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 2 of 7
Paul R. Riley, University of Oxford, UK
Developmental Programming of the Cardiac Lymphatics towards Heart Repair

Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 3 of 7
Kenneth D. Poss, Duke University Medical Center, USA
Endogenous Heart Regeneration Programs

Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 4 of 7
Charles E. Murry, University of Washington, USA
Cardiogenesis with Human Pluripotent Stem Cells

Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 5 of 7
Karl Tryggvason, Karolinska Institutet, Sweden
Using Laminins to Generate Therapeutic Cardiomyocytes from hES Cells

Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 6 of 7
Anna Blice-Baum, Johns Hopkins University, USA
Short Talk: Titered FOXO Overexpression Maintains Cardiac Proteostasis and Ameliorates Age-Associated Functional Decline

Thursday, April 07 | 8:00AM - 11:15AM
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Room: Ballroom 1-3

Speaker 7 of 7
Palmer Yu, Gladstone Institutes, USA
Short Talk: Regeneration of Cardiomyocytes in vivo Using Human Cardiac Reprogramming Factors in a Pig Model

Thursday, April 07 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Thursday, April 07 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, April 07 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, April 07 | 5:00PM - 6:45PM
Cardiomyocyte Maturation, Proliferation and Cardiac Remodeli
ng

Room: Ballroom 2

Speaker 1 of 4
* Bernd K. Fleischmann, Bonn University, Germany

Thursday, April 07 | 5:00PM - 6:45PM
Cardiomyocyte Maturation, Proliferation and Cardiac Remodeli
ng

Room: Ballroom 2

Speaker 2 of 4
Anthony J. Muslin, Tectonic Therapeutic, Inc., USA
Signal Transduction Pathways Related to Cardiac Hypertrophy

Thursday, April 07 | 5:00PM - 6:45PM
Cardiomyocyte Maturation, Proliferation and Cardiac Remodeli
ng

Room: Ballroom 2

Speaker 3 of 4
Jose Luis de la Pompa, Centro Nacional de Investigaciones Cardiovasculares, Spain
Notch Signaling in Ventricular Chamber Development and Disease

Thursday, April 07 | 5:00PM - 6:45PM
Cardiomyocyte Maturation, Proliferation and Cardiac Remodeli
ng

Room: Ballroom 2

Speaker 4 of 4
Thomas Braun, Germany
The Role of Dedifferentiated Cardiomyocytes in the Diseased Myocardium

Thursday, April 07 | 5:00PM - 6:45PM
Epigenetics and miRNAs: Muscle Failure and Arrhythmia Predis
position
This session is from Heart Failure

Room: Ballroom 1

Speaker 1 of 5
* Esther E. Creemers, Academic Medical Center, Netherlands


Thursday, April 07 | 5:00PM - 6:45PM
Epigenetics and miRNAs: Muscle Failure and Arrhythmia Predis
position
This session is from Heart Failure

Room: Ballroom 1

Speaker 2 of 5
* Joseph A. Hill, University of Texas Southwestern Medical Center, USA


Thursday, April 07 | 5:00PM - 6:45PM
Epigenetics and miRNAs: Muscle Failure and Arrhythmia Predis
position
This session is from Heart Failure

Room: Ballroom 1

Speaker 3 of 5
Stefan Engelhardt, Technical University of Munich, Germany
MiRNAs from Non-Muscle Cells


Thursday, April 07 | 5:00PM - 6:45PM
Epigenetics and miRNAs: Muscle Failure and Arrhythmia Predis
position
This session is from Heart Failure

Room: Ballroom 1

Speaker 4 of 5
Roger Foo, Genome Institute of Singapore, Singapore
What Single Cell Genomics Can Tell Us About Heart Failure


Thursday, April 07 | 5:00PM - 6:45PM
Epigenetics and miRNAs: Muscle Failure and Arrhythmia Predis
position
This session is from Heart Failure

Room: Ballroom 1

Speaker 5 of 5
Yigal M. Pinto, University of Amsterdam, Netherlands
Role of Cardiac Specific RNA Binding Proteins in Regulating miRNA Function


Thursday, April 07 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Ballroom 2


Thursday, April 07 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Heart Failure
Room: Ballroom 1


Thursday, April 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 2-3
No registration fees are used to fund alcohol served at this function.

Thursday, April 07 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2-3
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, April 07 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 2-3


Friday, April 08 | 10:25AM - 10:25AM
Departure


*Session Chair.