Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
	Neurodegenerative Diseases: New Insights and Therapeutic Opportunities (2019Z2)
Advances in Neurodegenerative Disease Research and Therapy (2018Z3)

Web Desc
Common Mechanisms of Neurodegeneration joint with Microglia in the Brain Organizer(s): Bradley T. Hyman, Adriano M. Aguzzi and Ricardo E. Dolmetsch Date: June 12 - 16, 2016 Location: Keystone Resort, Keystone, CO, USA Sponsored by BioLegend, Inc., Curemark LLC, FORUM Pharmaceuticals Inc., Merck & Co., Inc., Sangamo BioSciences, Inc. and Takeda Pharmaceutical Company Limited Summary of Meeting: Recent advances in understanding the genetics and underlying mechanisms of neurodegenerative diseases including prion diseases, Alzheimer’s, Parkinson’s, ALS and frontotemporal dementia have revealed overlaps of phenotypes, genetic risks and biological mechanisms across this spectrum of disorders. The “common mechanisms” include protein templating, glial and inflammatory mechanisms, new understanding of RNA-based toxicity and of toxicity associated with protein misfolding, and common downstream mechanisms affecting synaptic function. Moreover, because there appear to be common mechanisms at play, recent progress in therapeutic approaches targeting one of these disorders may have applicability across the whole range of disorders. This Keystone Symposia conference will enable the in-depth exploration of these various aspects of commonality across neurodegenerative disorders. Scholarship Deadline: February 11 2016 Discounted Abstract Deadline: February 11 2016 Abstract Deadline: March 10 2016 Discounted Registration Deadline: April 12 2016 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Eli Lilly and Company Novartis Institutes for BioMedical Research We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Neurological Disorders and Stroke (NINDS) Grant No. 1R13NS096941-01 The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Common Mechanisms of Neurodegeneration

joint with Microglia in the Brain

Organizer(s): Bradley T. Hyman, Adriano M. Aguzzi and Ricardo E. Dolmetsch

Date: June 12 - 16, 2016
Location: Keystone Resort, Keystone, CO, USA

Sponsored by BioLegend, Inc., Curemark LLC, FORUM Pharmaceuticals Inc., Merck & Co., Inc., Sangamo BioSciences, Inc. and Takeda Pharmaceutical Company Limited

Summary of Meeting:

Recent advances in understanding the genetics and underlying mechanisms of neurodegenerative diseases including prion diseases, Alzheimer’s, Parkinson’s, ALS and frontotemporal dementia have revealed overlaps of phenotypes, genetic risks and biological mechanisms across this spectrum of disorders. The “common mechanisms” include protein templating, glial and inflammatory mechanisms, new understanding of RNA-based toxicity and of toxicity associated with protein misfolding, and common downstream mechanisms affecting synaptic function. Moreover, because there appear to be common mechanisms at play, recent progress in therapeutic approaches targeting one of these disorders may have applicability across the whole range of disorders. This Keystone Symposia conference will enable the in-depth exploration of these various aspects of commonality across neurodegenerative disorders.

Scholarship Deadline: February 11 2016

Discounted Abstract Deadline: February 11 2016

Abstract Deadline: March 10 2016

Discounted Registration Deadline: April 12 2016

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Eli Lilly and Company

Novartis Institutes for BioMedical Research

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS096941-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, June 12 \| 4:00PM - 8:00PM Arrival and Registration Room: Longs Peak Foyer
Sunday, June 12 \| 6:00PM - 8:00PM Welcome Mixer Room: Longs Peak Foyer No registration fees are used to fund alcohol served at this function.
Monday, June 13 \| 7:30AM - 8:30AM Breakfast Room: Shavano/Torreys
Monday, June 13 \| 8:30AM - 9:30AM Welcome and Keynote Address Room: Longs Peak Speaker 1 of 2 * Bradley T. Hyman, Massachusetts General Hospital, USA
Monday, June 13 \| 8:30AM - 9:30AM Welcome and Keynote Address Room: Longs Peak Speaker 2 of 2 Laura Ranum, University of Florida, USA Repeat Associated Non-ATG (RAN) Translation: New Starts and Directions in Neurologic Disease
Monday, June 13 \| 9:30AM - 11:45AM Prions and 'Prionoid' Molecules Room: Longs Peak Speaker 1 of 5 Beat H. Meier, ETH Zürich, Switzerland Atomic-Resolution Structures of Amyloids: HET-s and Different Polymorphs of Amyloid Beta: What Can We Learn?
Monday, June 13 \| 9:30AM - 11:45AM Prions and 'Prionoid' Molecules Room: Longs Peak Coffee Break
Monday, June 13 \| 9:30AM - 11:45AM Prions and 'Prionoid' Molecules Room: Longs Peak Speaker 3 of 5 * Adriano M. Aguzzi, University Hospital of Zürich, Switzerland Prion Toxicity
Monday, June 13 \| 9:30AM - 11:45AM Prions and 'Prionoid' Molecules Room: Longs Peak Speaker 4 of 5 Tuomas Knowles, University of Cambridge, UK Kinetics of Protein Aggregation
Monday, June 13 \| 9:30AM - 11:45AM Prions and 'Prionoid' Molecules Room: Longs Peak Speaker 5 of 5 Kristen Anne Davenport, Colorado State University, USA Short Talk: Dissecting the Role of the PrP Amino Terminus in Species Barriers
Monday, June 13 \| 9:30AM - 12:15PM Genetics to Pathogenesis This session is from Microglia Room: Grays Peak Speaker 1 of 6 * Richard M. Ransohoff, Third Rock Ventures, USA
Monday, June 13 \| 9:30AM - 12:15PM Genetics to Pathogenesis This session is from Microglia Room: Grays Peak Speaker 2 of 6 Zbigniew K. Wszolek, Mayo Clinic College of Medicine, USA Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia due to CSF1R gene Mutations: Clinical, Radiological, Pathological and Genetic Correlations
Monday, June 13 \| 9:30AM - 12:15PM Genetics to Pathogenesis This session is from Microglia Room: Grays Peak Coffee Break
Monday, June 13 \| 9:30AM - 12:15PM Genetics to Pathogenesis This session is from Microglia Room: Grays Peak Speaker 4 of 6 Steven G. Younkin, Mayo Clinic Jacksonville, USA Association of Variants in Microglial Genes with Neurodegenerative Disease
Monday, June 13 \| 9:30AM - 12:15PM Genetics to Pathogenesis This session is from Microglia Room: Grays Peak Speaker 5 of 6 Karel Otero Gutierrez, EISAI, USA Investigating the Functions of TREM2 in Neurodegeneration
Monday, June 13 \| 9:30AM - 12:15PM Genetics to Pathogenesis This session is from Microglia Room: Grays Peak Speaker 6 of 6 Michael W. Salter, Hospital for Sick Children and University of Toronto, Canada Sexual Dimorphism in Microglia-Neuron Signaling in Pain Neuroplasticity
Monday, June 13 \| 11:45AM - 5:00PM On Own for Lunch
Monday, June 13 \| 11:45AM - 1:00PM Poster Setup Room: Shavano/Torreys
Monday, June 13 \| 1:00PM - 10:00PM Poster Viewing Room: Shavano/Torreys
Monday, June 13 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, June 13 \| 5:00PM - 7:00PM Protein Templating and Spread of Neuropathology Room: Longs Peak Speaker 1 of 3 Mathias Jucker, Hertie-Institute for Clinical Brain Research and DZNE, Germany Proteopathic Seeds in Neurodegenerative Diseases
Monday, June 13 \| 5:00PM - 7:00PM Protein Templating and Spread of Neuropathology Room: Longs Peak Speaker 2 of 3 * Bradley T. Hyman, Massachusetts General Hospital, USA Neuroanatomy and Consequences of Pathological Propagation in Neurodegeneration
Monday, June 13 \| 5:00PM - 7:00PM Protein Templating and Spread of Neuropathology Room: Longs Peak Speaker 3 of 3 Virginia M. Y. Lee, University of Pennsylvania School of Medicine, USA New Tauopathy Mouse Models for Alzheimer’s Disease
Monday, June 13 \| 5:00PM - 7:15PM Microglia Surveillance in Real Time: Lessons from in vivo Im aging This session is from Microglia Room: Grays Peak Speaker 1 of 6 * Marie-Ève Tremblay, Laval University, Canada
Monday, June 13 \| 5:00PM - 7:15PM Microglia Surveillance in Real Time: Lessons from in vivo Im aging This session is from Microglia Room: Grays Peak Speaker 2 of 6 David Attwell, University College London, UK An Ion Channel Regulating Microglial Surveillance of the Brain Parenchyma
Monday, June 13 \| 5:00PM - 7:15PM Microglia Surveillance in Real Time: Lessons from in vivo Im aging This session is from Microglia Room: Grays Peak Speaker 3 of 6 Dimitrios Davalos, Lerner Research Institute, Cleveland Clinic, USA Microglial Responses to Blood Brain Barrier Breakdown
Monday, June 13 \| 5:00PM - 7:15PM Microglia Surveillance in Real Time: Lessons from in vivo Im aging This session is from Microglia Room: Grays Peak Speaker 4 of 6 Francesca Peri, European Molecular Biology Laboratory, Germany Microglia Go Live: The Role Neuronal-Microglial Interactions in the Development and Repair of the CNS
Monday, June 13 \| 5:00PM - 7:15PM Microglia Surveillance in Real Time: Lessons from in vivo Im aging This session is from Microglia Room: Grays Peak Speaker 5 of 6 Courtney N. Easley-Neal, Eisai, USA Short Talk: Cerebral Cortex Targeted Depletion of Microglia, via CSF1R Ligand Inhibition, as a Potential Approach to Mitigate Neurodegeneration in Alzheimer’s Disease
Monday, June 13 \| 5:00PM - 7:15PM Microglia Surveillance in Real Time: Lessons from in vivo Im aging This session is from Microglia Room: Grays Peak Speaker 6 of 6 Deborah Kurrasch, University of Calgary, Canada Short Talk: Microglia Influence Embryonic Development of Hypothalamic Energy Balance Centers
Monday, June 13 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Monday, June 13 \| 7:30PM - 10:00PM Poster Session 1 Room: Shavano/Torreys
Tuesday, June 14 \| 7:30AM - 8:30AM Breakfast Room: Shavano/Torreys
Tuesday, June 14 \| 8:00AM - 8:30AM Poster Setup Room: Shavano/Torreys
Tuesday, June 14 \| 8:30AM - 5:00PM Poster Viewing Room: Shavano/Torreys
Tuesday, June 14 \| 8:30AM - 11:45AM New Treatment Modalities Room: Longs Peak Speaker 1 of 7 Christer Nordstedt, Eli Lilly and Company, USA Future Alzheimer's Therapeutics
Tuesday, June 14 \| 8:30AM - 11:45AM New Treatment Modalities Room: Longs Peak Speaker 2 of 7 * Nathalie Isabelle Cartier-Lacave, CEA MIRCen, France Gene Therapy Strategy for Alzheimer’s Disease: The Cholesterol Connection
Tuesday, June 14 \| 8:30AM - 11:45AM New Treatment Modalities Room: Longs Peak Coffee Break
Tuesday, June 14 \| 8:30AM - 11:45AM New Treatment Modalities Room: Longs Peak Speaker 4 of 7 Douglas Golenbock, University of Massachusetts Medical School, USA The Inflammasome Product IL18 Prevents Amyloid-Induced Fatal Seizures
Tuesday, June 14 \| 8:30AM - 11:45AM New Treatment Modalities Room: Longs Peak Speaker 5 of 7 Fyodor D. Urnov, University of California, Berkeley, USA Targeted Genome Regulation for Neurodegenerative Disease Therapy
Tuesday, June 14 \| 8:30AM - 11:45AM New Treatment Modalities Room: Longs Peak Speaker 6 of 7 Claire E. Le Pichon, NICHD, National Institutes of Health, USA Short Talk: Loss of Dual Leucine Zipper Kinase Signaling is Protective in the SOD1 Mouse Model of ALS
Tuesday, June 14 \| 8:30AM - 11:45AM New Treatment Modalities Room: Longs Peak Speaker 7 of 7 William J. Meilandt, Genentech, inc., USA Short Talk: Loss of Dual Leucine Zipper Kinase Signaling is Protective in the PS2APP Mouse Model of Alzheimer’s Disease
Tuesday, June 14 \| 8:30AM - 11:30AM Synaptic Pruning and Plasticity This session is from Microglia Room: Grays Peak Speaker 1 of 7 * Staci Bilbo, Duke University, USA
Tuesday, June 14 \| 8:30AM - 11:30AM Synaptic Pruning and Plasticity This session is from Microglia Room: Grays Peak Speaker 2 of 7 Dorothy Schafer, University of Massachusetts Medical School, USA Microglia: Dynamic Sensors of Neural Activity and Regulators of Brain Plasticity
Tuesday, June 14 \| 8:30AM - 11:30AM Synaptic Pruning and Plasticity This session is from Microglia Room: Grays Peak Speaker 3 of 7 Rosa C. Paolicelli, University of Lausanne, Switzerland TDP-43 Loss in Microglia Promotes Phagocytosis and affects Synaptic Pruning and Motor Behavior in Adult Mice
Tuesday, June 14 \| 8:30AM - 11:30AM Synaptic Pruning and Plasticity This session is from Microglia Room: Grays Peak Coffee Break
Tuesday, June 14 \| 8:30AM - 11:30AM Synaptic Pruning and Plasticity This session is from Microglia Room: Grays Peak Speaker 5 of 7 Brian MacVicar, University of British Columbia, Canada Synaptic Sensing and Modulation by Microglia
Tuesday, June 14 \| 8:30AM - 11:30AM Synaptic Pruning and Plasticity This session is from Microglia Room: Grays Peak Speaker 6 of 7 Ryuta Koyama, University of Tokyo, Japan Short Talk: Fever Activates Microglia to Engulf Inhibitory Synapses in Epilepsy
Tuesday, June 14 \| 8:30AM - 11:30AM Synaptic Pruning and Plasticity This session is from Microglia Room: Grays Peak Speaker 7 of 7 Ukpong B. Eyo, Mayo Clinic, USA Short Talk: Bi-Directional Microglial-Neuronal Interactions During Glutamate-Induced Hyperactivity
Tuesday, June 14 \| 11:45AM - 12:30PM Lunch Room: Shavano/Torreys
Tuesday, June 14 \| 12:00PM - 2:30PM Poster Session 2 Room: Shavano/Torreys
Tuesday, June 14 \| 2:30PM - 3:30PM Workshop 1: Ontogeny and Development This session is from Microglia Room: Grays Peak Speaker 1 of 4 * Florent Ginhoux, Singapore Immunology Network, Singapore Modeling Microglial Differentiation and Function in vitro using Induced Pluripotent Stem Cells
Tuesday, June 14 \| 2:30PM - 3:30PM Workshop 1: Ontogeny and Development This session is from Microglia Room: Grays Peak Speaker 2 of 4 Morgane S. Thion, INSERM U1024, France In utero Development of Microglia: Intrinsic Programs and Impact of Microbiota
Tuesday, June 14 \| 2:30PM - 3:30PM Workshop 1: Ontogeny and Development This session is from Microglia Room: Grays Peak Speaker 3 of 4 Huixin Xu, Boston Children's Hospital, USA Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid Beta-Protein Oligomers
Tuesday, June 14 \| 2:30PM - 3:30PM Workshop 1: Ontogeny and Development This session is from Microglia Room: Grays Peak Speaker 4 of 4 Xianhua Piao, University of California San Francisco, USA Microglial Transglutaminase-2 (TG2) Regulates Oligodendrocyte Development and CNS Myelination through GPR56 Signaling
Tuesday, June 14 \| 3:30PM - 4:30PM Workshop 2: Models and Techniques I This session is from Microglia Room: Grays Peak Speaker 1 of 4 * Dimitrios Davalos, Lerner Research Institute, Cleveland Clinic, USA
Tuesday, June 14 \| 3:30PM - 4:30PM Workshop 2: Models and Techniques I This session is from Microglia Room: Grays Peak Speaker 2 of 4 Steven Marinero, Duke University, USA 3D Brain Tissue-Based Model for Probing Contributions of Microglia and Peripheral Macrophages in Driving Neurodegenerative Disease Mechanisms
Tuesday, June 14 \| 3:30PM - 4:30PM Workshop 2: Models and Techniques I This session is from Microglia Room: Grays Peak Speaker 3 of 4 Susanna Rosi, University of California, San Francisco, USA In vivo Metabolic Imaging of Neuroinflammation after TBI
Tuesday, June 14 \| 3:30PM - 4:30PM Workshop 2: Models and Techniques I This session is from Microglia Room: Grays Peak Speaker 4 of 4 Santiago Sole Domenech, Weill Cornell Medicine, USA Intravital Imaging of Acidic Compartments in Mouse Brain Microglia
Tuesday, June 14 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, June 14 \| 5:00PM - 7:00PM Role of Glia Room: Longs Peak Speaker 1 of 4 * Don W. Cleveland, University of California, San Diego, USA Mechanism and Therapy in ALS and Beyond
Tuesday, June 14 \| 5:00PM - 7:00PM Role of Glia Room: Longs Peak Speaker 2 of 4 Shane Antony Liddelow, New York University Langone Medical Center, USA What Do Reactive Astrocytes Do?
Tuesday, June 14 \| 5:00PM - 7:00PM Role of Glia Room: Longs Peak Speaker 3 of 4 Serge Przedborski, Columbia University, USA Molecular Mechanism of Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis
Tuesday, June 14 \| 5:00PM - 7:00PM Role of Glia Room: Longs Peak Speaker 4 of 4 Brian V. Lananna, University of Washington in St. Louis, USA Short Talk: The Astrocyte Circadian Clock Regulates Astrogliosis and Neuronal Injury
Tuesday, June 14 \| 5:00PM - 7:00PM Role in Neurodevelopmental and Neuropsychiatric Disorders This session is from Microglia Room: Grays Peak Speaker 1 of 4 * Dorothy Schafer, University of Massachusetts Medical School, USA
Tuesday, June 14 \| 5:00PM - 7:00PM Role in Neurodevelopmental and Neuropsychiatric Disorders This session is from Microglia Room: Grays Peak Speaker 2 of 4 Staci Bilbo, Duke University, USA Modulation of Microglia by Maternal Immune Activation: Relevance for Autism
Tuesday, June 14 \| 5:00PM - 7:00PM Role in Neurodevelopmental and Neuropsychiatric Disorders This session is from Microglia Room: Grays Peak Speaker 3 of 4 Mario R. Capecchi, University of Utah, USA A Causal Role for Defective Microglia in the OCD-Spectrum Disorder, Trichotillomania
Tuesday, June 14 \| 5:00PM - 7:00PM Role in Neurodevelopmental and Neuropsychiatric Disorders This session is from Microglia Room: Grays Peak Speaker 4 of 4 Beth Stevens, Boston Children's Hospital, Harvard Medical School, USA Microglia Function and Dysfunction During Brain Wiring
Tuesday, June 14 \| 7:00PM - 7:00PM On Own for Dinner
Wednesday, June 15 \| 7:30AM - 8:30AM Breakfast Room: Shavano/Torreys
Wednesday, June 15 \| 8:30AM - 9:15AM Special Lecture This session is from Microglia Room: Grays Peak Speaker 1 of 1 Marco Prinz, University of Freiburg, Germany Origin and Function of CNS Macrophages
Wednesday, June 15 \| 8:30AM - 11:30AM RNA and New Mechanisms of Toxicity Room: Longs Peak Speaker 1 of 6 J. Paul Taylor, St. Jude Children's Research Hospital, USA Disturbed Phase Transitions Underlie Most Forms of ALS and FTD
Wednesday, June 15 \| 8:30AM - 11:30AM RNA and New Mechanisms of Toxicity Room: Longs Peak Speaker 2 of 6 Eva-Maria Hock, University of Zürich, Switzerland Short Talk: Understanding the Involvement of Cellular Stress in the Initiation of TDP-43 and FUS Pathology in Slice Culture Models
Wednesday, June 15 \| 8:30AM - 11:30AM RNA and New Mechanisms of Toxicity Room: Longs Peak Speaker 3 of 6 Maurice S. Swanson, University of Florida, USA Dynamic Mutations and RNA-Mediated Disease Mechanisms
Wednesday, June 15 \| 8:30AM - 11:30AM RNA and New Mechanisms of Toxicity Room: Longs Peak Coffee Break
Wednesday, June 15 \| 8:30AM - 11:30AM RNA and New Mechanisms of Toxicity Room: Longs Peak Speaker 5 of 6 * Magdalini Polymenidou, University of Zürich, Switzerland The Intertwined Roles of RNA Misregulation and Protein Aggregation in ALS and FTD
Wednesday, June 15 \| 8:30AM - 11:30AM RNA and New Mechanisms of Toxicity Room: Longs Peak Speaker 6 of 6 Josh Dubnau, Stony Brook University, USA Short Talk: The Retrotransposon Storm: Retrotransposon Activation Causes Neurodegeneration in a Drosophila TDP-43 Model of Amyotrophic Lateral Sclerosis
Wednesday, June 15 \| 9:15AM - 11:30AM Microglia in Aging and Neurodegenerative Disease This session is from Microglia Room: Grays Peak Speaker 1 of 6 * Thomas Möller, Foundational Neuroscience Center, USA
Wednesday, June 15 \| 9:15AM - 11:30AM Microglia in Aging and Neurodegenerative Disease This session is from Microglia Room: Grays Peak Speaker 2 of 6 Marie-Ève Tremblay, Laval University, Canada Dark Microglia: A New Phenotype Predominantly Associated with Pathological States
Wednesday, June 15 \| 9:15AM - 11:30AM Microglia in Aging and Neurodegenerative Disease This session is from Microglia Room: Grays Peak Coffee Break
Wednesday, June 15 \| 9:15AM - 11:30AM Microglia in Aging and Neurodegenerative Disease This session is from Microglia Room: Grays Peak Speaker 4 of 6 Gary E. Landreth, Case Western Reserve University, USA Nuclear Receptors License the Phagocytic Clearance of Amyloid by Plaque-Associated Macrophages from the AD Brain
Wednesday, June 15 \| 9:15AM - 11:30AM Microglia in Aging and Neurodegenerative Disease This session is from Microglia Room: Grays Peak Speaker 5 of 6 Daniel Wilton, Boston Children’s Hospital, Harvard Medical School, USA Short Talk: Microglia Mediate Early Loss of Specific Synaptic Connections in Huntington's Disease
Wednesday, June 15 \| 9:15AM - 11:30AM Microglia in Aging and Neurodegenerative Disease This session is from Microglia Room: Grays Peak Speaker 6 of 6 Michelle K. Cahill, University of California, San Francisco, USA Short Talk: Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
Wednesday, June 15 \| 11:30AM - 12:30PM Panel: Career Development in Biotech and Pharma This session is from Microglia Room: Grays Peak Speaker 1 of 6 Adam W. Bero, Biogen, USA
Wednesday, June 15 \| 11:30AM - 12:30PM Panel: Career Development in Biotech and Pharma This session is from Microglia Room: Grays Peak Speaker 2 of 6 Irena Kadiu, UCB BioPharma SPRL, Belgium
Wednesday, June 15 \| 11:30AM - 12:30PM Panel: Career Development in Biotech and Pharma This session is from Microglia Room: Grays Peak Speaker 3 of 6 Morag Stewart, VL49, USA
Wednesday, June 15 \| 11:30AM - 12:30PM Panel: Career Development in Biotech and Pharma This session is from Microglia Room: Grays Peak Speaker 4 of 6 Sean P. Cook, Teva Pharmaceuticals, USA
Wednesday, June 15 \| 11:30AM - 12:30PM Panel: Career Development in Biotech and Pharma This session is from Microglia Room: Grays Peak Speaker 5 of 6 Peter S. DiStefano, Zebra Biologics, Inc, USA
Wednesday, June 15 \| 11:30AM - 12:30PM Panel: Career Development in Biotech and Pharma This session is from Microglia Room: Grays Peak Speaker 6 of 6 Matthew Kennedy, Merck Research Labs, USA
Wednesday, June 15 \| 11:30AM - 5:00PM On Own for Lunch
Wednesday, June 15 \| 11:30AM - 1:00PM Poster Setup Room: Shavano/Torreys
Wednesday, June 15 \| 1:00PM - 10:00PM Poster Viewing Room: Shavano/Torreys
Wednesday, June 15 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, June 15 \| 5:00PM - 7:00PM Inflammatory Mechanisms Room: Longs Peak Speaker 1 of 3 Gabor Veres, Bluebird Bio, USA Clinical Study Update on the Efficacy and Safety of Ex Vivo Gene Therapy with Lenti-D Lentiviral Vector for the Treatment of Cerebral Adrenoleukodystrophy
Wednesday, June 15 \| 5:00PM - 7:00PM Inflammatory Mechanisms Room: Longs Peak Speaker 2 of 3 Richard M. Ransohoff, Third Rock Ventures, USA (Re)Introducing Microglia
Wednesday, June 15 \| 5:00PM - 7:00PM Inflammatory Mechanisms Room: Longs Peak Speaker 3 of 3 Jennifer Lee, Johns Hopkins University, USA Hypothermia and Rewarming Activate a White Matter Macroglial Unfolded Protein Response Independent of Hypoxia-Ischemia in a Piglet Model
Wednesday, June 15 \| 5:00PM - 7:00PM Profiling Resident Microglia in Health and Disease This session is from Microglia Room: Grays Peak Speaker 1 of 5 * Marco Prinz, University of Freiburg, Germany
Wednesday, June 15 \| 5:00PM - 7:00PM Profiling Resident Microglia in Health and Disease This session is from Microglia Room: Grays Peak Speaker 2 of 5 Shane Antony Liddelow, New York University Langone Medical Center, USA Identification of Novel Microglia-Specific Markers in Healthy Mouse Brain
Wednesday, June 15 \| 5:00PM - 7:00PM Profiling Resident Microglia in Health and Disease This session is from Microglia Room: Grays Peak Speaker 3 of 5 Joseph El Khoury, Massachusetts General Hospital, USA Deep Sequencing Brain Microglia Reveals Unique Molecular Fingerprints
Wednesday, June 15 \| 5:00PM - 7:00PM Profiling Resident Microglia in Health and Disease This session is from Microglia Room: Grays Peak Speaker 4 of 5 Erik H.W.G.M. Boddeke, University of Groningen, Netherlands Human and Mouse Microglia Transcriptomes Related to Neurodegeneration and Aging
Wednesday, June 15 \| 5:00PM - 7:00PM Profiling Resident Microglia in Health and Disease This session is from Microglia Room: Grays Peak Speaker 5 of 5 Brad A. Friedman, Genentech, Inc., USA Short Talk: The Transcriptional Landscape of Brain Myeloid Cells Reveals Gene Expression Responses Associated with Proliferation, Interferon Signaling and Neurodegeneration
Wednesday, June 15 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Wednesday, June 15 \| 7:30PM - 10:00PM Poster Session 3 Room: Shavano/Torreys
Thursday, June 16 \| 7:30AM - 8:30AM Breakfast Room: Shavano/Torreys
Thursday, June 16 \| 8:30AM - 11:30AM Unfolded Proteins Room: Longs Peak Speaker 1 of 6 * Richard I. Morimoto, Northwestern University, USA Proteostasis Disruptions in Aging and Neurodegenerative Disease
Thursday, June 16 \| 8:30AM - 11:30AM Unfolded Proteins Room: Longs Peak Speaker 2 of 6 David Eisenberg, University of California, Los Angeles, USA Structural Studies of Toxic and Non-Toxic Amyloid Proteins
Thursday, June 16 \| 8:30AM - 11:30AM Unfolded Proteins Room: Longs Peak Coffee Break
Thursday, June 16 \| 8:30AM - 11:30AM Unfolded Proteins Room: Longs Peak Speaker 4 of 6 Gordon P. Meares, West Virginia University, USA Short Talk: Targeting PERK for Selective Immunomodulation in the CNS
Thursday, June 16 \| 8:30AM - 11:30AM Unfolded Proteins Room: Longs Peak Speaker 5 of 6 Christoph Gericke, University of Zurich, Switzerland Short Talk: The Influence of Alzheimer’s Disease-Like Cerebral Amyloidosis on Brain Immune Surveillance
Thursday, June 16 \| 8:30AM - 11:30AM Unfolded Proteins Room: Longs Peak Speaker 6 of 6 David Christopher Wirthensohn, University of Cambridge, UK Short Talk: Detecting and Characterizing Individual Aggregates in Human CSF
Thursday, June 16 \| 8:30AM - 11:45AM Microglia Regulation of Pain and Neuronal-Glia Interactions This session is from Microglia Room: Grays Peak Speaker 1 of 8 * Francesca Peri, European Molecular Biology Laboratory, Germany
Thursday, June 16 \| 8:30AM - 11:45AM Microglia Regulation of Pain and Neuronal-Glia Interactions This session is from Microglia Room: Grays Peak Speaker 2 of 8 Richard M. Ransohoff, Third Rock Ventures, USA The Fractalkine Story: An Update
Thursday, June 16 \| 8:30AM - 11:45AM Microglia Regulation of Pain and Neuronal-Glia Interactions This session is from Microglia Room: Grays Peak Speaker 3 of 8 Sonia Garel, INSERM, France Microglia and Prenatal Inflammation in the Development of Cortical Inhibitory Circuits
Thursday, June 16 \| 8:30AM - 11:45AM Microglia Regulation of Pain and Neuronal-Glia Interactions This session is from Microglia Room: Grays Peak Coffee Break
Thursday, June 16 \| 8:30AM - 11:45AM Microglia Regulation of Pain and Neuronal-Glia Interactions This session is from Microglia Room: Grays Peak Speaker 5 of 8 Amanda Sierra, Achucarro Basque Center for Neuroscience, Spain Short Talk: Of Ghost Cells and Ravenous Microglia: Coupling between Apoptosis and Microglial Phagocytosis in Health and Disease
Thursday, June 16 \| 8:30AM - 11:45AM Microglia Regulation of Pain and Neuronal-Glia Interactions This session is from Microglia Room: Grays Peak Speaker 6 of 8 Makoto Tsuda, Kyushu University, Japan Spinal Microglia Activated by Purinergic Signaling and Neuropathic Pain
Thursday, June 16 \| 8:30AM - 11:45AM Microglia Regulation of Pain and Neuronal-Glia Interactions This session is from Microglia Room: Grays Peak Speaker 7 of 8 Marzia Malcangio, King's College London, UK Neural-immune Interactions in Chronic Pain Mechanisms
Thursday, June 16 \| 8:30AM - 11:45AM Microglia Regulation of Pain and Neuronal-Glia Interactions This session is from Microglia Room: Grays Peak Speaker 8 of 8 Tuan Trang, University of Calgary, Canada Short Talk: Pain, Poppies, and Pannexin-1 Channels on Microglia
Thursday, June 16 \| 11:30AM - 5:00PM On Own for Lunch
Thursday, June 16 \| 2:30PM - 3:30PM Workshop 3: Models and Techniques II This session is from Microglia Room: Grays Peak Speaker 1 of 5 * Beth Stevens, Boston Children's Hospital, Harvard Medical School, USA
Thursday, June 16 \| 2:30PM - 3:30PM Workshop 3: Models and Techniques II This session is from Microglia Room: Grays Peak Speaker 2 of 5 Julien A. Muffat, Whitehead Institute for Biomedical Research, USA Modeling Neuro-Immune Interactions in CNS Disorders using Patient iPS-Derived Microglia-Like Cells
Thursday, June 16 \| 2:30PM - 3:30PM Workshop 3: Models and Techniques II This session is from Microglia Room: Grays Peak Speaker 3 of 5 Ana Badimon, Mount Sinai School of Medicine, USA Brain Region Specific Microglia Specification
Thursday, June 16 \| 2:30PM - 3:30PM Workshop 3: Models and Techniques II This session is from Microglia Room: Grays Peak Speaker 4 of 5 Edsel M. Abud, University of California, Irvine, USA Generating Microglia from Human iPSCs to Study Alzheimer’s Disease
Thursday, June 16 \| 2:30PM - 3:30PM Workshop 3: Models and Techniques II This session is from Microglia Room: Grays Peak Speaker 5 of 5 Petr Tvrdik, University of Virginia, USA Imaging and Analysis of Intracellular Calcium Dynamics in Cortical Microglia Responding to Injury
Thursday, June 16 \| 3:30PM - 4:30PM Brainstorming and Open Discussion This session is from Microglia Room: Grays Peak Speaker 1 of 1 * Beth Stevens, Boston Children's Hospital, Harvard Medical School, USA
Thursday, June 16 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, June 16 \| 5:00PM - 6:00PM Synaptic Dysfunction in AD, Neurodegenerative Disease, and D evelopmental Disorders Room: Longs Peak Speaker 1 of 2 Tara L. Spires-Jones, University of Edinburgh, UK Dynamic Synaptic Alterations Due to Amyloid Beta and Tau
Thursday, June 16 \| 5:00PM - 6:00PM Synaptic Dysfunction in AD, Neurodegenerative Disease, and D evelopmental Disorders Room: Longs Peak Speaker 2 of 2 * Ricardo E. Dolmetsch, uniQure, USA Synaptic Alterations as a Drug Target
Thursday, June 16 \| 5:00PM - 6:45PM Special Lectures This session is from Microglia Room: Grays Peak Speaker 1 of 3 * Richard M. Ransohoff, Third Rock Ventures, USA
Thursday, June 16 \| 5:00PM - 6:45PM Special Lectures This session is from Microglia Room: Grays Peak Speaker 2 of 3 Adriano M. Aguzzi, University Hospital of Zürich, Switzerland Immunological Aspects of Prion Diseases
Thursday, June 16 \| 5:00PM - 6:45PM Special Lectures This session is from Microglia Room: Grays Peak Speaker 3 of 3 Thomas Möller, Foundational Neuroscience Center, USA Translating Microglial Biology: Promise and Problems
Thursday, June 16 \| 6:00PM - 6:45PM Closing Keynote Address Room: Longs Peak Speaker 1 of 1 Beth Stevens, Boston Children's Hospital, Harvard Medical School, USA How Microglia Prune Specific Synapses in Health & Disease
Thursday, June 16 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Longs Peak
Thursday, June 16 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) This session is from Microglia Room: Grays Peak
Thursday, June 16 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Thursday, June 16 \| 8:00PM - 11:00PM Entertainment Room: Shavano/Torreys Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, June 16 \| 8:00PM - 11:00PM Cash Bar Room: Shavano/Torreys
Friday, June 17 \| 10:25AM - 10:25AM Departure *Session Chair.