Web Desc
Common Mechanisms of Neurodegeneration
joint with Microglia in the Brain
Organizer(s): Bradley T. Hyman, Adriano M. Aguzzi and Ricardo E. Dolmetsch
Date: June 12 - 16, 2016
Location: Keystone Resort, Keystone, CO, USA
Sponsored by BioLegend, Inc., Curemark LLC, FORUM Pharmaceuticals Inc., Merck & Co., Inc., Sangamo BioSciences, Inc. and Takeda Pharmaceutical Company Limited
Summary of Meeting:
Recent advances in understanding the genetics and underlying mechanisms of neurodegenerative diseases including prion diseases, Alzheimer’s, Parkinson’s, ALS and frontotemporal dementia have revealed overlaps of phenotypes, genetic risks and biological mechanisms across this spectrum of disorders. The “common mechanisms” include protein templating, glial and inflammatory mechanisms, new understanding of RNA-based toxicity and of toxicity associated with protein misfolding, and common downstream mechanisms affecting synaptic function. Moreover, because there appear to be common mechanisms at play, recent progress in therapeutic approaches targeting one of these disorders may have applicability across the whole range of disorders. This Keystone Symposia conference will enable the in-depth exploration of these various aspects of commonality across neurodegenerative disorders.
Scholarship Deadline: February 11 2016
Discounted Abstract Deadline: February 11 2016
Abstract Deadline: March 10 2016
Discounted Registration Deadline: April 12 2016
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
BioLegend, Inc.Curemark LLCFORUM Pharmaceuticals Inc.Merck & Co., Inc.Sangamo BioSciences, Inc.Takeda Pharmaceutical Company Limited
We gratefully acknowledge additional support for this conference from:
Bethyl Laboratories, Inc.Bio-TechneNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Eli Lilly and Company

Novartis Institutes for BioMedical Research
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
NeuroscientistNews
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS096941-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, June 12 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, June 12 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, June 13 | 7:30AM - 8:30AM
Breakfast
Room: Shavano/Torreys


Monday, June 13 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Longs Peak

Speaker 1 of 2
* Bradley T. Hyman, Massachusetts General Hospital, USA

Monday, June 13 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Longs Peak

Speaker 2 of 2
Laura Ranum, University of Florida, USA
Repeat Associated Non-ATG (RAN) Translation: New Starts and Directions in Neurologic Disease

Monday, June 13 | 9:30AM - 11:45AM
Prions and 'Prionoid' Molecules
Room: Longs Peak

Speaker 1 of 5
Beat H. Meier, ETH Zürich, Switzerland
Atomic-Resolution Structures of Amyloids: HET-s and Different Polymorphs of Amyloid Beta: What Can We Learn?


Monday, June 13 | 9:30AM - 11:45AM
Prions and 'Prionoid' Molecules
Room: Longs Peak


Coffee Break

Monday, June 13 | 9:30AM - 11:45AM
Prions and 'Prionoid' Molecules
Room: Longs Peak

Speaker 3 of 5
* Adriano M. Aguzzi, University Hospital of Zürich, Switzerland
Prion Toxicity

Monday, June 13 | 9:30AM - 11:45AM
Prions and 'Prionoid' Molecules
Room: Longs Peak

Speaker 4 of 5
Tuomas Knowles, University of Cambridge, UK
Kinetics of Protein Aggregation

Monday, June 13 | 9:30AM - 11:45AM
Prions and 'Prionoid' Molecules
Room: Longs Peak

Speaker 5 of 5
Kristen Anne Davenport, Colorado State University, USA
Short Talk: Dissecting the Role of the PrP Amino Terminus in Species Barriers

Monday, June 13 | 9:30AM - 12:15PM
Genetics to Pathogenesis
This session is from Microglia
Room: Grays Peak

Speaker 1 of 6
* Richard M. Ransohoff, Third Rock Ventures, USA


Monday, June 13 | 9:30AM - 12:15PM
Genetics to Pathogenesis
This session is from Microglia
Room: Grays Peak

Speaker 2 of 6
Zbigniew K. Wszolek, Mayo Clinic College of Medicine, USA
Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia due to CSF1R gene Mutations: Clinical, Radiological, Pathological and Genetic Correlations


Monday, June 13 | 9:30AM - 12:15PM
Genetics to Pathogenesis
This session is from Microglia
Room: Grays Peak


Coffee Break


Monday, June 13 | 9:30AM - 12:15PM
Genetics to Pathogenesis
This session is from Microglia
Room: Grays Peak

Speaker 4 of 6
Steven G. Younkin, Mayo Clinic Jacksonville, USA
Association of Variants in Microglial Genes with Neurodegenerative Disease


Monday, June 13 | 9:30AM - 12:15PM
Genetics to Pathogenesis
This session is from Microglia
Room: Grays Peak

Speaker 5 of 6
Karel Otero Gutierrez, EISAI, USA
Investigating the Functions of TREM2 in Neurodegeneration


Monday, June 13 | 9:30AM - 12:15PM
Genetics to Pathogenesis
This session is from Microglia
Room: Grays Peak

Speaker 6 of 6
Michael W. Salter, Hospital for Sick Children and University of Toronto, Canada
Sexual Dimorphism in Microglia-Neuron Signaling in Pain Neuroplasticity


Monday, June 13 | 11:45AM - 5:00PM
On Own for Lunch


Monday, June 13 | 11:45AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Monday, June 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Monday, June 13 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, June 13 | 5:00PM - 7:00PM
Protein Templating and Spread of Neuropathology
Room: Longs Peak

Speaker 1 of 3
Mathias Jucker, Hertie-Institute for Clinical Brain Research and DZNE, Germany
Proteopathic Seeds in Neurodegenerative Diseases

Monday, June 13 | 5:00PM - 7:00PM
Protein Templating and Spread of Neuropathology
Room: Longs Peak

Speaker 2 of 3
* Bradley T. Hyman, Massachusetts General Hospital, USA
Neuroanatomy and Consequences of Pathological Propagation in Neurodegeneration

Monday, June 13 | 5:00PM - 7:00PM
Protein Templating and Spread of Neuropathology
Room: Longs Peak

Speaker 3 of 3
Virginia M. Y. Lee, University of Pennsylvania School of Medicine, USA
New Tauopathy Mouse Models for Alzheimer’s Disease

Monday, June 13 | 5:00PM - 7:15PM
Microglia Surveillance in Real Time: Lessons from in vivo Im
aging
This session is from Microglia

Room: Grays Peak

Speaker 1 of 6
* Marie-Ève Tremblay, Laval University, Canada


Monday, June 13 | 5:00PM - 7:15PM
Microglia Surveillance in Real Time: Lessons from in vivo Im
aging
This session is from Microglia

Room: Grays Peak

Speaker 2 of 6
David Attwell, University College London, UK
An Ion Channel Regulating Microglial Surveillance of the Brain Parenchyma


Monday, June 13 | 5:00PM - 7:15PM
Microglia Surveillance in Real Time: Lessons from in vivo Im
aging
This session is from Microglia

Room: Grays Peak

Speaker 3 of 6
Dimitrios Davalos, Lerner Research Institute, Cleveland Clinic, USA
Microglial Responses to Blood Brain Barrier Breakdown


Monday, June 13 | 5:00PM - 7:15PM
Microglia Surveillance in Real Time: Lessons from in vivo Im
aging
This session is from Microglia

Room: Grays Peak

Speaker 4 of 6
Francesca Peri, European Molecular Biology Laboratory, Germany
Microglia Go Live: The Role Neuronal-Microglial Interactions in the Development and Repair of the CNS


Monday, June 13 | 5:00PM - 7:15PM
Microglia Surveillance in Real Time: Lessons from in vivo Im
aging
This session is from Microglia

Room: Grays Peak

Speaker 5 of 6
Courtney N. Easley-Neal, Eisai, USA
Short Talk: Cerebral Cortex Targeted Depletion of Microglia, via CSF1R Ligand Inhibition, as a Potential Approach to Mitigate Neurodegeneration in Alzheimer’s Disease


Monday, June 13 | 5:00PM - 7:15PM
Microglia Surveillance in Real Time: Lessons from in vivo Im
aging
This session is from Microglia

Room: Grays Peak

Speaker 6 of 6
Deborah Kurrasch, University of Calgary, Canada
Short Talk: Microglia Influence Embryonic Development of Hypothalamic Energy Balance Centers


Monday, June 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Monday, June 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Tuesday, June 14 | 7:30AM - 8:30AM
Breakfast
Room: Shavano/Torreys


Tuesday, June 14 | 8:00AM - 8:30AM
Poster Setup
Room: Shavano/Torreys


Tuesday, June 14 | 8:30AM - 5:00PM
Poster Viewing
Room: Shavano/Torreys


Tuesday, June 14 | 8:30AM - 11:45AM
New Treatment Modalities
Room: Longs Peak

Speaker 1 of 7
Christer Nordstedt, Eli Lilly and Company, USA
Future Alzheimer's Therapeutics

Tuesday, June 14 | 8:30AM - 11:45AM
New Treatment Modalities
Room: Longs Peak

Speaker 2 of 7
* Nathalie Isabelle Cartier-Lacave, CEA MIRCen, France
Gene Therapy Strategy for Alzheimer’s Disease: The Cholesterol Connection

Tuesday, June 14 | 8:30AM - 11:45AM
New Treatment Modalities
Room: Longs Peak


Coffee Break

Tuesday, June 14 | 8:30AM - 11:45AM
New Treatment Modalities
Room: Longs Peak

Speaker 4 of 7
Douglas Golenbock, University of Massachusetts Medical School, USA
The Inflammasome Product IL18 Prevents Amyloid-Induced Fatal Seizures

Tuesday, June 14 | 8:30AM - 11:45AM
New Treatment Modalities
Room: Longs Peak

Speaker 5 of 7
Fyodor D. Urnov, University of California, Berkeley, USA
Targeted Genome Regulation for Neurodegenerative Disease Therapy

Tuesday, June 14 | 8:30AM - 11:45AM
New Treatment Modalities
Room: Longs Peak

Speaker 6 of 7
Claire E. Le Pichon, NICHD, National Institutes of Health, USA
Short Talk: Loss of Dual Leucine Zipper Kinase Signaling is Protective in the SOD1 Mouse Model of ALS

Tuesday, June 14 | 8:30AM - 11:45AM
New Treatment Modalities
Room: Longs Peak

Speaker 7 of 7
William J. Meilandt, Genentech, inc., USA
Short Talk: Loss of Dual Leucine Zipper Kinase Signaling is Protective in the PS2APP Mouse Model of Alzheimer’s Disease

Tuesday, June 14 | 8:30AM - 11:30AM
Synaptic Pruning and Plasticity
This session is from Microglia
Room: Grays Peak

Speaker 1 of 7
* Staci Bilbo, Duke University, USA


Tuesday, June 14 | 8:30AM - 11:30AM
Synaptic Pruning and Plasticity
This session is from Microglia
Room: Grays Peak

Speaker 2 of 7
Dorothy Schafer, University of Massachusetts Medical School, USA
Microglia: Dynamic Sensors of Neural Activity and Regulators of Brain Plasticity


Tuesday, June 14 | 8:30AM - 11:30AM
Synaptic Pruning and Plasticity
This session is from Microglia
Room: Grays Peak

Speaker 3 of 7
Rosa C. Paolicelli, University of Lausanne, Switzerland
TDP-43 Loss in Microglia Promotes Phagocytosis and affects Synaptic Pruning and Motor Behavior in Adult Mice


Tuesday, June 14 | 8:30AM - 11:30AM
Synaptic Pruning and Plasticity
This session is from Microglia
Room: Grays Peak


Coffee Break


Tuesday, June 14 | 8:30AM - 11:30AM
Synaptic Pruning and Plasticity
This session is from Microglia
Room: Grays Peak

Speaker 5 of 7
Brian MacVicar, University of British Columbia, Canada
Synaptic Sensing and Modulation by Microglia


Tuesday, June 14 | 8:30AM - 11:30AM
Synaptic Pruning and Plasticity
This session is from Microglia
Room: Grays Peak

Speaker 6 of 7
Ryuta Koyama, University of Tokyo, Japan
Short Talk: Fever Activates Microglia to Engulf Inhibitory Synapses in Epilepsy


Tuesday, June 14 | 8:30AM - 11:30AM
Synaptic Pruning and Plasticity
This session is from Microglia
Room: Grays Peak

Speaker 7 of 7
Ukpong B. Eyo, Mayo Clinic, USA
Short Talk: Bi-Directional Microglial-Neuronal Interactions During Glutamate-Induced Hyperactivity


Tuesday, June 14 | 11:45AM - 12:30PM
Lunch
Room: Shavano/Torreys


Tuesday, June 14 | 12:00PM - 2:30PM
Poster Session 2
Room: Shavano/Torreys


Tuesday, June 14 | 2:30PM - 3:30PM
Workshop 1: Ontogeny and Development
This session is from Microglia
Room: Grays Peak

Speaker 1 of 4
* Florent Ginhoux, Singapore Immunology Network, Singapore
Modeling Microglial Differentiation and Function in vitro using Induced Pluripotent Stem Cells


Tuesday, June 14 | 2:30PM - 3:30PM
Workshop 1: Ontogeny and Development
This session is from Microglia
Room: Grays Peak

Speaker 2 of 4
Morgane S. Thion, INSERM U1024, France
In utero Development of Microglia: Intrinsic Programs and Impact of Microbiota


Tuesday, June 14 | 2:30PM - 3:30PM
Workshop 1: Ontogeny and Development
This session is from Microglia
Room: Grays Peak

Speaker 3 of 4
Huixin Xu, Boston Children's Hospital, USA
Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid Beta-Protein Oligomers


Tuesday, June 14 | 2:30PM - 3:30PM
Workshop 1: Ontogeny and Development
This session is from Microglia
Room: Grays Peak

Speaker 4 of 4
Xianhua Piao, University of California San Francisco, USA
Microglial Transglutaminase-2 (TG2) Regulates Oligodendrocyte Development and CNS Myelination through GPR56 Signaling


Tuesday, June 14 | 3:30PM - 4:30PM
Workshop 2: Models and Techniques I
This session is from Microglia
Room: Grays Peak

Speaker 1 of 4
* Dimitrios Davalos, Lerner Research Institute, Cleveland Clinic, USA


Tuesday, June 14 | 3:30PM - 4:30PM
Workshop 2: Models and Techniques I
This session is from Microglia
Room: Grays Peak

Speaker 2 of 4
Steven Marinero, Duke University, USA
3D Brain Tissue-Based Model for Probing Contributions of Microglia and Peripheral Macrophages in Driving Neurodegenerative Disease Mechanisms


Tuesday, June 14 | 3:30PM - 4:30PM
Workshop 2: Models and Techniques I
This session is from Microglia
Room: Grays Peak

Speaker 3 of 4
Susanna Rosi, University of California, San Francisco, USA
In vivo Metabolic Imaging of Neuroinflammation after TBI


Tuesday, June 14 | 3:30PM - 4:30PM
Workshop 2: Models and Techniques I
This session is from Microglia
Room: Grays Peak

Speaker 4 of 4
Santiago Sole Domenech, Weill Cornell Medicine, USA
Intravital Imaging of Acidic Compartments in Mouse Brain Microglia


Tuesday, June 14 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, June 14 | 5:00PM - 7:00PM
Role of Glia
Room: Longs Peak

Speaker 1 of 4
* Don W. Cleveland, University of California, San Diego, USA
Mechanism and Therapy in ALS and Beyond

Tuesday, June 14 | 5:00PM - 7:00PM
Role of Glia
Room: Longs Peak

Speaker 2 of 4
Shane Antony Liddelow, New York University Langone Medical Center, USA
What Do Reactive Astrocytes Do?

Tuesday, June 14 | 5:00PM - 7:00PM
Role of Glia
Room: Longs Peak

Speaker 3 of 4
Serge Przedborski, Columbia University, USA
Molecular Mechanism of Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis

Tuesday, June 14 | 5:00PM - 7:00PM
Role of Glia
Room: Longs Peak

Speaker 4 of 4
Brian V. Lananna, University of Washington in St. Louis, USA
Short Talk: The Astrocyte Circadian Clock Regulates Astrogliosis and Neuronal Injury

Tuesday, June 14 | 5:00PM - 7:00PM
Role in Neurodevelopmental and Neuropsychiatric Disorders
This session is from Microglia
Room: Grays Peak

Speaker 1 of 4
* Dorothy Schafer, University of Massachusetts Medical School, USA


Tuesday, June 14 | 5:00PM - 7:00PM
Role in Neurodevelopmental and Neuropsychiatric Disorders
This session is from Microglia
Room: Grays Peak

Speaker 2 of 4
Staci Bilbo, Duke University, USA
Modulation of Microglia by Maternal Immune Activation: Relevance for Autism


Tuesday, June 14 | 5:00PM - 7:00PM
Role in Neurodevelopmental and Neuropsychiatric Disorders
This session is from Microglia
Room: Grays Peak

Speaker 3 of 4
Mario R. Capecchi, University of Utah, USA
A Causal Role for Defective Microglia in the OCD-Spectrum Disorder, Trichotillomania


Tuesday, June 14 | 5:00PM - 7:00PM
Role in Neurodevelopmental and Neuropsychiatric Disorders
This session is from Microglia
Room: Grays Peak

Speaker 4 of 4
Beth Stevens, Boston Children's Hospital, Harvard Medical School, USA
Microglia Function and Dysfunction During Brain Wiring


Tuesday, June 14 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, June 15 | 7:30AM - 8:30AM
Breakfast
Room: Shavano/Torreys


Wednesday, June 15 | 8:30AM - 9:15AM
Special Lecture
This session is from Microglia
Room: Grays Peak

Speaker 1 of 1
Marco Prinz, University of Freiburg, Germany
Origin and Function of CNS Macrophages


Wednesday, June 15 | 8:30AM - 11:30AM
RNA and New Mechanisms of Toxicity
Room: Longs Peak

Speaker 1 of 6
J. Paul Taylor, St. Jude Children's Research Hospital, USA
Disturbed Phase Transitions Underlie Most Forms of ALS and FTD

Wednesday, June 15 | 8:30AM - 11:30AM
RNA and New Mechanisms of Toxicity
Room: Longs Peak

Speaker 2 of 6
Eva-Maria Hock, University of Zürich, Switzerland
Short Talk: Understanding the Involvement of Cellular Stress in the Initiation of TDP-43 and FUS Pathology in Slice Culture Models

Wednesday, June 15 | 8:30AM - 11:30AM
RNA and New Mechanisms of Toxicity
Room: Longs Peak

Speaker 3 of 6
Maurice S. Swanson, University of Florida, USA
Dynamic Mutations and RNA-Mediated Disease Mechanisms

Wednesday, June 15 | 8:30AM - 11:30AM
RNA and New Mechanisms of Toxicity
Room: Longs Peak


Coffee Break

Wednesday, June 15 | 8:30AM - 11:30AM
RNA and New Mechanisms of Toxicity
Room: Longs Peak

Speaker 5 of 6
* Magdalini Polymenidou, University of Zürich, Switzerland
The Intertwined Roles of RNA Misregulation and Protein Aggregation in ALS and FTD

Wednesday, June 15 | 8:30AM - 11:30AM
RNA and New Mechanisms of Toxicity
Room: Longs Peak

Speaker 6 of 6
Josh Dubnau, Stony Brook University, USA
Short Talk: The Retrotransposon Storm: Retrotransposon Activation Causes Neurodegeneration in a Drosophila TDP-43 Model of Amyotrophic Lateral Sclerosis

Wednesday, June 15 | 9:15AM - 11:30AM
Microglia in Aging and Neurodegenerative Disease
This session is from Microglia
Room: Grays Peak

Speaker 1 of 6
* Thomas Möller, Foundational Neuroscience Center, USA


Wednesday, June 15 | 9:15AM - 11:30AM
Microglia in Aging and Neurodegenerative Disease
This session is from Microglia
Room: Grays Peak

Speaker 2 of 6
Marie-Ève Tremblay, Laval University, Canada
Dark Microglia: A New Phenotype Predominantly Associated with Pathological States


Wednesday, June 15 | 9:15AM - 11:30AM
Microglia in Aging and Neurodegenerative Disease
This session is from Microglia
Room: Grays Peak


Coffee Break


Wednesday, June 15 | 9:15AM - 11:30AM
Microglia in Aging and Neurodegenerative Disease
This session is from Microglia
Room: Grays Peak

Speaker 4 of 6
Gary E. Landreth, Case Western Reserve University, USA
Nuclear Receptors License the Phagocytic Clearance of Amyloid by Plaque-Associated Macrophages from the AD Brain


Wednesday, June 15 | 9:15AM - 11:30AM
Microglia in Aging and Neurodegenerative Disease
This session is from Microglia
Room: Grays Peak

Speaker 5 of 6
Daniel Wilton, Boston Children’s Hospital, Harvard Medical School, USA
Short Talk: Microglia Mediate Early Loss of Specific Synaptic Connections in Huntington's Disease


Wednesday, June 15 | 9:15AM - 11:30AM
Microglia in Aging and Neurodegenerative Disease
This session is from Microglia
Room: Grays Peak

Speaker 6 of 6
Michelle K. Cahill, University of California, San Francisco, USA
Short Talk: Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation


Wednesday, June 15 | 11:30AM - 12:30PM
Panel: Career Development in Biotech and Pharma
This session is from Microglia
Room: Grays Peak

Speaker 1 of 6
Adam W. Bero, Biogen, USA


Wednesday, June 15 | 11:30AM - 12:30PM
Panel: Career Development in Biotech and Pharma
This session is from Microglia
Room: Grays Peak

Speaker 2 of 6
Irena Kadiu, UCB BioPharma SPRL, Belgium


Wednesday, June 15 | 11:30AM - 12:30PM
Panel: Career Development in Biotech and Pharma
This session is from Microglia
Room: Grays Peak

Speaker 3 of 6
Morag Stewart, VL49, USA


Wednesday, June 15 | 11:30AM - 12:30PM
Panel: Career Development in Biotech and Pharma
This session is from Microglia
Room: Grays Peak

Speaker 4 of 6
Sean P. Cook, Teva Pharmaceuticals, USA


Wednesday, June 15 | 11:30AM - 12:30PM
Panel: Career Development in Biotech and Pharma
This session is from Microglia
Room: Grays Peak

Speaker 5 of 6
Peter S. DiStefano, Zebra Biologics, Inc, USA


Wednesday, June 15 | 11:30AM - 12:30PM
Panel: Career Development in Biotech and Pharma
This session is from Microglia
Room: Grays Peak

Speaker 6 of 6
Matthew Kennedy, Merck Research Labs, USA


Wednesday, June 15 | 11:30AM - 5:00PM
On Own for Lunch


Wednesday, June 15 | 11:30AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Wednesday, June 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Wednesday, June 15 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, June 15 | 5:00PM - 7:00PM
Inflammatory Mechanisms
Room: Longs Peak

Speaker 1 of 3
Gabor Veres, Bluebird Bio, USA
Clinical Study Update on the Efficacy and Safety of Ex Vivo Gene Therapy with Lenti-D Lentiviral Vector for the Treatment of Cerebral Adrenoleukodystrophy

Wednesday, June 15 | 5:00PM - 7:00PM
Inflammatory Mechanisms
Room: Longs Peak

Speaker 2 of 3
Richard M. Ransohoff, Third Rock Ventures, USA
(Re)Introducing Microglia

Wednesday, June 15 | 5:00PM - 7:00PM
Inflammatory Mechanisms
Room: Longs Peak

Speaker 3 of 3
Jennifer Lee, Johns Hopkins University, USA
Hypothermia and Rewarming Activate a White Matter Macroglial Unfolded Protein Response Independent of Hypoxia-Ischemia in a Piglet Model

Wednesday, June 15 | 5:00PM - 7:00PM
Profiling Resident Microglia in Health and Disease
This session is from Microglia
Room: Grays Peak

Speaker 1 of 5
* Marco Prinz, University of Freiburg, Germany


Wednesday, June 15 | 5:00PM - 7:00PM
Profiling Resident Microglia in Health and Disease
This session is from Microglia
Room: Grays Peak

Speaker 2 of 5
Shane Antony Liddelow, New York University Langone Medical Center, USA
Identification of Novel Microglia-Specific Markers in Healthy Mouse Brain


Wednesday, June 15 | 5:00PM - 7:00PM
Profiling Resident Microglia in Health and Disease
This session is from Microglia
Room: Grays Peak

Speaker 3 of 5
Joseph El Khoury, Massachusetts General Hospital, USA
Deep Sequencing Brain Microglia Reveals Unique Molecular Fingerprints


Wednesday, June 15 | 5:00PM - 7:00PM
Profiling Resident Microglia in Health and Disease
This session is from Microglia
Room: Grays Peak

Speaker 4 of 5
Erik H.W.G.M. Boddeke, University of Groningen, Netherlands
Human and Mouse Microglia Transcriptomes Related to Neurodegeneration and Aging


Wednesday, June 15 | 5:00PM - 7:00PM
Profiling Resident Microglia in Health and Disease
This session is from Microglia
Room: Grays Peak

Speaker 5 of 5
Brad A. Friedman, Genentech, Inc., USA
Short Talk: The Transcriptional Landscape of Brain Myeloid Cells Reveals Gene Expression Responses Associated with Proliferation, Interferon Signaling and Neurodegeneration


Wednesday, June 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Wednesday, June 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Shavano/Torreys


Thursday, June 16 | 7:30AM - 8:30AM
Breakfast
Room: Shavano/Torreys


Thursday, June 16 | 8:30AM - 11:30AM
Unfolded Proteins
Room: Longs Peak

Speaker 1 of 6
* Richard I. Morimoto, Northwestern University, USA
Proteostasis Disruptions in Aging and Neurodegenerative Disease

Thursday, June 16 | 8:30AM - 11:30AM
Unfolded Proteins
Room: Longs Peak

Speaker 2 of 6
David Eisenberg, University of California, Los Angeles, USA
Structural Studies of Toxic and Non-Toxic Amyloid Proteins

Thursday, June 16 | 8:30AM - 11:30AM
Unfolded Proteins
Room: Longs Peak


Coffee Break

Thursday, June 16 | 8:30AM - 11:30AM
Unfolded Proteins
Room: Longs Peak

Speaker 4 of 6
Gordon P. Meares, West Virginia University, USA
Short Talk: Targeting PERK for Selective Immunomodulation in the CNS

Thursday, June 16 | 8:30AM - 11:30AM
Unfolded Proteins
Room: Longs Peak

Speaker 5 of 6
Christoph Gericke, University of Zurich, Switzerland
Short Talk: The Influence of Alzheimer’s Disease-Like Cerebral Amyloidosis on Brain Immune Surveillance

Thursday, June 16 | 8:30AM - 11:30AM
Unfolded Proteins
Room: Longs Peak

Speaker 6 of 6
David Christopher Wirthensohn, University of Cambridge, UK
Short Talk: Detecting and Characterizing Individual Aggregates in Human CSF

Thursday, June 16 | 8:30AM - 11:45AM
Microglia Regulation of Pain and Neuronal-Glia Interactions
This session is from Microglia
Room: Grays Peak

Speaker 1 of 8
* Francesca Peri, European Molecular Biology Laboratory, Germany


Thursday, June 16 | 8:30AM - 11:45AM
Microglia Regulation of Pain and Neuronal-Glia Interactions
This session is from Microglia
Room: Grays Peak

Speaker 2 of 8
Richard M. Ransohoff, Third Rock Ventures, USA
The Fractalkine Story: An Update


Thursday, June 16 | 8:30AM - 11:45AM
Microglia Regulation of Pain and Neuronal-Glia Interactions
This session is from Microglia
Room: Grays Peak

Speaker 3 of 8
Sonia Garel, INSERM, France
Microglia and Prenatal Inflammation in the Development of Cortical Inhibitory Circuits


Thursday, June 16 | 8:30AM - 11:45AM
Microglia Regulation of Pain and Neuronal-Glia Interactions
This session is from Microglia
Room: Grays Peak


Coffee Break


Thursday, June 16 | 8:30AM - 11:45AM
Microglia Regulation of Pain and Neuronal-Glia Interactions
This session is from Microglia
Room: Grays Peak

Speaker 5 of 8
Amanda Sierra, Achucarro Basque Center for Neuroscience, Spain
Short Talk: Of Ghost Cells and Ravenous Microglia: Coupling between Apoptosis and Microglial Phagocytosis in Health and Disease


Thursday, June 16 | 8:30AM - 11:45AM
Microglia Regulation of Pain and Neuronal-Glia Interactions
This session is from Microglia
Room: Grays Peak

Speaker 6 of 8
Makoto Tsuda, Kyushu University, Japan
Spinal Microglia Activated by Purinergic Signaling and Neuropathic Pain


Thursday, June 16 | 8:30AM - 11:45AM
Microglia Regulation of Pain and Neuronal-Glia Interactions
This session is from Microglia
Room: Grays Peak

Speaker 7 of 8
Marzia Malcangio, King's College London, UK
Neural-immune Interactions in Chronic Pain Mechanisms


Thursday, June 16 | 8:30AM - 11:45AM
Microglia Regulation of Pain and Neuronal-Glia Interactions
This session is from Microglia
Room: Grays Peak

Speaker 8 of 8
Tuan Trang, University of Calgary, Canada
Short Talk: Pain, Poppies, and Pannexin-1 Channels on Microglia


Thursday, June 16 | 11:30AM - 5:00PM
On Own for Lunch


Thursday, June 16 | 2:30PM - 3:30PM
Workshop 3: Models and Techniques II
This session is from Microglia
Room: Grays Peak

Speaker 1 of 5
* Beth Stevens, Boston Children's Hospital, Harvard Medical School, USA


Thursday, June 16 | 2:30PM - 3:30PM
Workshop 3: Models and Techniques II
This session is from Microglia
Room: Grays Peak

Speaker 2 of 5
Julien A. Muffat, Whitehead Institute for Biomedical Research, USA
Modeling Neuro-Immune Interactions in CNS Disorders using Patient iPS-Derived Microglia-Like Cells


Thursday, June 16 | 2:30PM - 3:30PM
Workshop 3: Models and Techniques II
This session is from Microglia
Room: Grays Peak

Speaker 3 of 5
Ana Badimon, Mount Sinai School of Medicine, USA
Brain Region Specific Microglia Specification


Thursday, June 16 | 2:30PM - 3:30PM
Workshop 3: Models and Techniques II
This session is from Microglia
Room: Grays Peak

Speaker 4 of 5
Edsel M. Abud, University of California, Irvine, USA
Generating Microglia from Human iPSCs to Study Alzheimer’s Disease


Thursday, June 16 | 2:30PM - 3:30PM
Workshop 3: Models and Techniques II
This session is from Microglia
Room: Grays Peak

Speaker 5 of 5
Petr Tvrdik, University of Virginia, USA
Imaging and Analysis of Intracellular Calcium Dynamics in Cortical Microglia Responding to Injury


Thursday, June 16 | 3:30PM - 4:30PM
Brainstorming and Open Discussion
This session is from Microglia
Room: Grays Peak

Speaker 1 of 1
* Beth Stevens, Boston Children's Hospital, Harvard Medical School, USA


Thursday, June 16 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, June 16 | 5:00PM - 6:00PM
Synaptic Dysfunction in AD, Neurodegenerative Disease, and D
evelopmental Disorders

Room: Longs Peak

Speaker 1 of 2
Tara L. Spires-Jones, University of Edinburgh, UK
Dynamic Synaptic Alterations Due to Amyloid Beta and Tau

Thursday, June 16 | 5:00PM - 6:00PM
Synaptic Dysfunction in AD, Neurodegenerative Disease, and D
evelopmental Disorders

Room: Longs Peak

Speaker 2 of 2
* Ricardo E. Dolmetsch, uniQure, USA
Synaptic Alterations as a Drug Target

Thursday, June 16 | 5:00PM - 6:45PM
Special Lectures
This session is from Microglia
Room: Grays Peak

Speaker 1 of 3
* Richard M. Ransohoff, Third Rock Ventures, USA


Thursday, June 16 | 5:00PM - 6:45PM
Special Lectures
This session is from Microglia
Room: Grays Peak

Speaker 2 of 3
Adriano M. Aguzzi, University Hospital of Zürich, Switzerland
Immunological Aspects of Prion Diseases


Thursday, June 16 | 5:00PM - 6:45PM
Special Lectures
This session is from Microglia
Room: Grays Peak

Speaker 3 of 3
Thomas Möller, Foundational Neuroscience Center, USA
Translating Microglial Biology: Promise and Problems


Thursday, June 16 | 6:00PM - 6:45PM
Closing Keynote Address
Room: Longs Peak

Speaker 1 of 1
Beth Stevens, Boston Children's Hospital, Harvard Medical School, USA
How Microglia Prune Specific Synapses in Health & Disease

Thursday, June 16 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Longs Peak


Thursday, June 16 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Microglia
Room: Grays Peak


Thursday, June 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Thursday, June 16 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, June 16 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Friday, June 17 | 10:25AM - 10:25AM
Departure


*Session Chair.