Web Desc
Cell Plasticity within the Tumor Microenvironment
Organizer(s): Sergei Grivennikov, Florian R. Greten and Mikala Egeblad
Date: January 08 - 12, 2017
Location: Big Sky Resort, Big Sky, MT, USA
Sponsored by Journal of Molecular Cell Biology (JMCB) and Roche
For important information on the coronavirus, please click here
Summary of Meeting:
During the last decade, it has become unequivocally evident that tumor development is not a cell-autonomous process but rather depends on the intricate reciprocal interplay of mutant tumor cells with their local and distant environments. Composition and polarization of cells in the tumor microenvironment depends on genetic as well as environmental factors and is directly influenced by tumor therapy. Indeed, therapies that aim to shape the local immune milieu and consecutive signaling pathways in both stromal and tumor/stem cells address the complex pathophysiology of tumors more adequately and may therefore add substantial benefits for therapy. An absolute pre-requisite for such an endeavor is a comprehensive understanding of the exact molecular basis of the complex signaling networks in the tumor microenvironment that control the plasticity of both stromal and tumor cells, thereby shaping the complex cellular contexture, which ultimately forms a pro- or anti-tumorigenic milieu. Thus, this symposium aims to gather a comprehensive functional understanding of mediator-dependent cellular and molecular events that are responsible for the plasticity of both stromal and tumor/stem cells. It will bring together experts in cancer, stromal and immune cells to synthesize scientific knowledge about the phenomenon of cell plasticity within the tumor microenvironment, to define molecular and cellular pathways mediating plasticity and to propose approaches to interfere with cell plasticity for a new generation of effective therapeutic approaches in cancer and chronic injury. Importantly, it will bring together interdisciplinary groups of scientists or investigators who normally would not have an opportunity to meet (classical cancer biologists, tumor immunobiologists, stem cell experts and scientists working on stromal cells).
Scholarship Deadline: September 19 2016
Discounted Abstract Deadline: September 19 2016
Abstract Deadline: October 6 2016
Discounted Registration Deadline: November 8 2016
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Journal of Molecular Cell Biology (JMCB)Roche
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

EMBO Young Investigator Programme

Genentech, Inc.
$50,000+
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA210497-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, January 08 | 4:00PM - 8:00PM
Arrival and Registration
Room: Lower Atrium


Sunday, January 08 | 6:00PM - 8:00PM
Welcome Mixer
Room: Jefferson
No registration fees are used to fund alcohol served at this function.

Monday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Monday, January 09 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Jefferson/Madison

Speaker 1 of 4
* Sergei Grivennikov, Fox Chase Cancer Center, USA

Monday, January 09 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Jefferson/Madison

Speaker 2 of 4
* Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany

Monday, January 09 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Jefferson/Madison

Speaker 3 of 4
* Mikala Egeblad, Cold Spring Harbor Laboratory, USA

Monday, January 09 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Jefferson/Madison

Speaker 4 of 4
Michael Karin, University of California, San Diego, USA
Tumor-Elicited Inflammation and the Initiation of Colorectal Cancer

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison

Speaker 1 of 13
* Cédric Blanpain, Universite Libre de Bruxelles, Belgium

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison

Speaker 2 of 13
* Shelly Peyton, University of Massachusetts, USA

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison

Speaker 3 of 13
Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany
Inflammatory Signaling in Intestinal Stem Cell Plasticity

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison

Speaker 4 of 13
John Cassidy, Cambridge Cancer Genomics, UK
Short Talk: The Development of Tamoxifen Resistance is Linked to Oct4 Driven Transcriptional Plasticity

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison


Coffee Break

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison

Speaker 6 of 13
Andrew J. Ewald, Johns Hopkins University School of Medicine, USA
Phenotypic Plasticity during Cell Invasion and Metastasis

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison

Speaker 7 of 13
Kristiaan Lenos, Amsterdam Medical Center, Netherlands
Short Talk: Spatiotemporal Regulation of Stem Cell Function in Colon Cancer

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison

Speaker 8 of 13
Frederic J. de Sauvage, Genentech, Inc., USA
Targeting Intestinal Stem Cells in Cancer

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison

Speaker 9 of 13
Brian Bierie, Whitehead Institute for Biomedical Research, USA
Poster Teaser: Integrin-Beta4 Identifies Cancer Stem Cell-Enriched Populations of Partially-Mesenchymal Carcinoma Cells

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison

Speaker 10 of 13
Jessica L. Christenson, University of Colorado, USA
Poster Teaser: The Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression: Tumor-Intrinsic and Tumor-Extrinsic Mechanisms

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison

Speaker 11 of 13
Ryan Carpenter, University of Massachusetts, Amherst, USA
Poster Teaser: Capturing Microenvironmental Regulation of Metastatic Dormancy and Recurrence

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison

Speaker 12 of 13
Sara E. Berkey, University of Pittsburgh, USA
Poster Teaser: The IL17+Foxp3+ and exTh17 Foxp3+ Plastic T Cells Comprise Novel Immunosuppressive Regulatory T Cell Subsets in Tumors

Monday, January 09 | 9:00AM - 11:45AM
Plasticity of Epithelial, Cancer and Stem Cells
Room: Jefferson/Madison

Speaker 13 of 13
Oxana Dmitrieva-Posocco, University of Pennsylvania, USA
Poster Teaser: The Role of IL-1R-Signaling in Tumor Elicited Inflammation and Colon Cancer

Monday, January 09 | 11:45AM - 2:30PM
On Own for Lunch


Monday, January 09 | 11:45AM - 1:00PM
Poster Setup
Room: Gallatin


Monday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Monday, January 09 | 2:30PM - 4:30PM
Workshop 1: Plasticity and the Cancer Stem Cell Niche
Room: Jefferson/Madison

Speaker 1 of 8
* Diana Leigh Avery, University of Pennsylvania School of Medicine, USA
Matrix Mechanics and Composition Dictate Stromal Cell Differentiation in Lung Tumorigenesis

Monday, January 09 | 2:30PM - 4:30PM
Workshop 1: Plasticity and the Cancer Stem Cell Niche
Room: Jefferson/Madison

Speaker 2 of 8
Ikbale El Ayachi, University of Tennessee Health Science Center, USA
The Absence of Wnt10b Expression Inhibits Tumor Initiation and Metastasis Modulating Stroma-Tumor Microenvironment Homeostasis

Monday, January 09 | 2:30PM - 4:30PM
Workshop 1: Plasticity and the Cancer Stem Cell Niche
Room: Jefferson/Madison

Speaker 3 of 8
* Loukia Georgiou Karacosta, Stanford University, USA
Identifying Dynamic EMT Transition States in Lung Cancer Using Single Cell Multidimensional Analysis

Monday, January 09 | 2:30PM - 4:30PM
Workshop 1: Plasticity and the Cancer Stem Cell Niche
Room: Jefferson/Madison

Speaker 4 of 8
Hazel Quinn, Max Delbruck Centre, Germany
Genetically Interfering with the Tumor Microenvironment via Shh in Wnt-Met driven Mouse Triple Negative Breast Cancer

Monday, January 09 | 2:30PM - 4:30PM
Workshop 1: Plasticity and the Cancer Stem Cell Niche
Room: Jefferson/Madison

Speaker 5 of 8
Michael Buchert, Olivia Newton-John Cancer Research Institute, Australia
Insights into the Role of DCLK1 as a Novel Driver of Gastric Cancer

Monday, January 09 | 2:30PM - 4:30PM
Workshop 1: Plasticity and the Cancer Stem Cell Niche
Room: Jefferson/Madison

Speaker 6 of 8
Toni Celia-Terrassa, Princeton University, USA
Pathways Regulating the Evasion of Normal and Cancer Stem Cells
from Interferon-Imposed Constraint


Monday, January 09 | 2:30PM - 4:30PM
Workshop 1: Plasticity and the Cancer Stem Cell Niche
Room: Jefferson/Madison

Speaker 7 of 8
Dejan Maglic, Relay Therapeutics, USA
The Hedgehog and Hippo Pathways Cooperate in BCC Initiation and Progression

Monday, January 09 | 2:30PM - 4:30PM
Workshop 1: Plasticity and the Cancer Stem Cell Niche
Room: Jefferson/Madison

Speaker 8 of 8
Hélène Salmon, Institut Curie and Mount Sinai School of Medicine, France
The Tumor Microenvironment Controls Tumor Response to Checkpoint Blockade

Monday, January 09 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Monday, January 09 | 5:00PM - 7:00PM
Plasticity and the (Cancer) Stem Cell Niche
Room: Jefferson/Madison

Speaker 1 of 6
* Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany

Monday, January 09 | 5:00PM - 7:00PM
Plasticity and the (Cancer) Stem Cell Niche
Room: Jefferson/Madison

Speaker 2 of 6
* Louis Vermeulen, CEMM, Netherlands

Monday, January 09 | 5:00PM - 7:00PM
Plasticity and the (Cancer) Stem Cell Niche
Room: Jefferson/Madison

Speaker 3 of 6
Jing Yang, University of California, San Diego, USA
Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis

Monday, January 09 | 5:00PM - 7:00PM
Plasticity and the (Cancer) Stem Cell Niche
Room: Jefferson/Madison

Speaker 4 of 6
Cédric Blanpain, Universite Libre de Bruxelles, Belgium
Skin Tumor Stemness and Progression

Monday, January 09 | 5:00PM - 7:00PM
Plasticity and the (Cancer) Stem Cell Niche
Room: Jefferson/Madison

Speaker 5 of 6
Ekrem Emrah Er, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Pericytic Spreading of Disseminated Cancer Cells Initiate Multi-Organ Metastasis

Monday, January 09 | 5:00PM - 7:00PM
Plasticity and the (Cancer) Stem Cell Niche
Room: Jefferson/Madison

Speaker 6 of 6
Mathias Florian Heikenwälder, German Cancer Research Center, DKFZ, Germany
Kupffer-Cell Derived TNF Preferentially Triggers Cholangiocellular Carcinoma through JNK under Chronic Mitochondrial Dysfunction and ROS

Monday, January 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Gallatin
No registration fees are used to fund alcohol served at this function.

Monday, January 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Gallatin


Tuesday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 1 of 14
* Jing Yang, University of California, San Diego, USA

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 2 of 14
* Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School, USA

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 3 of 14
Thomas Tüting, Otto-von-Guericke University, Germany
Inflammation-Induced Phenotypic Plasticity of Tumor and Immune Cells as a Mechanism of Disease Progression and Therapy Resistance in Melanoma

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 4 of 14
Neta Erez, Tel Aviv University, Israel
Short Talk: Cancer-Associated Fibroblasts Link Tissue Damage with Tumor-Promoting Inflammation in Breast Cancer

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 5 of 14
Brian W. Wong, Washington University School of Medicine, USA
Endothelial versus Cancer Cell Metabolism

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison


Coffee Break

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 7 of 14
Valerie M. Weaver, University of California, San Francisco, USA
Extracellular Matrix and Tumor Mechanics

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 8 of 14
Shelly Peyton, University of Massachusetts, USA
Short Talk: Dynamics of Fibronectin Assembly and Tumor Cell Latency

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 9 of 14
Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
The Functional Role of EMT and Exosomes in Pancreatic Cancer

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 10 of 14
Chen Hao Lo, Moffitt Cancer Center, USA
Poster Teaser: Temporal Dynamics of Macrophage Plasticity in Bone Metastatic Prostate Cancer

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 11 of 14
Magdolna Djurec, Spanish National Cancer Research Center, Spain
Poster Teaser: Reprogramming Cancer Associated Fibroblasts as a Therapeutic Approach against Pancreatic Ductal Adenocarcinoma

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 12 of 14
Ayse Nihan Kilinc, University of Basel, Switzerland
Poster Teaser: The Contribution of Epithelial-Mesenchymal Plasticity to Cancer Stemness

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 13 of 14
Lennart Kester, Hubrecht Institute, Netherlands
Poster Teaser: Clonal Dynamics with Single Cell Resolution in Different Stages of Colon Carcinoma

Tuesday, January 10 | 8:00AM - 11:30AM
Cell Types Contributing to the Plasticity of the Tumor Micro
environment

Room: Jefferson/Madison

Speaker 14 of 14
Natsuko Kimura, University of Tokyo, Japan
Poster Teaser: Maintenance of Stemness and Niche Environment of Breast Cancer Cells by FRS2beta, a Feedback Inhibitor for HER2-ERK Pathway, during Mammary Tumorigenesis

Tuesday, January 10 | 11:30AM - 5:00PM
On Own for Lunch


Tuesday, January 10 | 11:30AM - 1:00PM
Poster Setup
Room: Gallatin


Tuesday, January 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Tuesday, January 10 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Tuesday, January 10 | 5:00PM - 7:00PM
Plasticity of Immune Cells within the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 1 of 6
* Alana L. Welm, University of Utah School of Medicine, USA

Tuesday, January 10 | 5:00PM - 7:00PM
Plasticity of Immune Cells within the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 2 of 6
* Mikala Egeblad, Cold Spring Harbor Laboratory, USA

Tuesday, January 10 | 5:00PM - 7:00PM
Plasticity of Immune Cells within the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 3 of 6
Peter Friedl, NCMLS, Radboud University Nijmegen Medical Centre, Netherlands
Serial Killing of Tumor Cells – Impact of the Microenvironment

Tuesday, January 10 | 5:00PM - 7:00PM
Plasticity of Immune Cells within the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 4 of 6
Giorgio Trinchieri, NCI, National Institutes of Health, USA
Cancer as a Meta-Organism – Fine-Tuning of Tumor Progression and Response to Therapy by Microbiota-Regulated Immune Cells

Tuesday, January 10 | 5:00PM - 7:00PM
Plasticity of Immune Cells within the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 5 of 6
Melissa A. Meyer, La Jolla Institute for Immunology, USA
Short Talk: Tumor-Induced IRF8 Deficiency Interrupts BATF3-Dependent Dendritic Cells Development

Tuesday, January 10 | 5:00PM - 7:00PM
Plasticity of Immune Cells within the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 6 of 6
Sergei Grivennikov, Fox Chase Cancer Center, USA
Tumor-Elicited Inflammation and Cytokines at Crossroads in Wound Healing and Tumor Progression

Tuesday, January 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Gallatin
No registration fees are used to fund alcohol served at this function.

Tuesday, January 10 | 7:30PM - 10:00PM
Poster Session 2
Room: Gallatin


Wednesday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison

Speaker 1 of 13
* Carla V. Rothlin, Yale University, USA

Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison

Speaker 2 of 13
* Neta Erez, Tel Aviv University, Israel

Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison

Speaker 3 of 13
Erik A. Sahai, Francis Crick Institute, UK
Tumor-Stroma Cross-Talk in Metastasis and Therapy Failure

Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison

Speaker 4 of 13
Andreas Trumpp, German Cancer Research Center, Germany
Stratification and Resistance Mechanisms in Pancreatic Cancer

Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison

Speaker 5 of 13
Annelise Snyder, University of Washington, USA
Short Talk: Necroptotic Cell Death within the Tumor Microenvironment Promotes Tumor Control

Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison


Coffee Break

Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison

Speaker 7 of 13
Alana L. Welm, University of Utah School of Medicine, USA
Ron Kinase in Bone Remodeling and Bone Metastasis

Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison

Speaker 8 of 13
Sheila A. Stewart, Washington University School of Medicine, USA
Short Talk: Inhibition of Stromal p38MAPK Abrogates Breast Cancer Metastases

Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison

Speaker 9 of 13
Robert F. Schwabe, Columbia University, USA
Fibrosis Promotes the Development of Liver Cancer

Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison

Speaker 10 of 13
Mario A. Shields, Cold Spring Harbor Laboratory, USA
Poster Teaser: Lysyl Oxidases Suppress Pancreatic Cancer Progression and Inhibit FAK and ERK Signaling

Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison

Speaker 11 of 13
Suzanne M. Ponik, University of Wisconsin-Madison, USA
Poster Teaser: Collagen Matrix Density Drives the Metabolic Profile Shift of Breast Cancer Cells

Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison

Speaker 12 of 13
Daniel C. Rabe, University of Chicago, USA
Poster Teaser: Exosome Crosstalk between Tumors and Tumor-Associated Macrophages Drives Pro-Invasive Plasticity

Wednesday, January 11 | 8:00AM - 11:30AM
Parallels between Normal Tissue Repair Response and Oncogene
sis

Room: Jefferson/Madison

Speaker 13 of 13
Julia Varga, Georg Speyer Haus, Germany
Poster Teaser: Notch3 Activation in Response to Aberrant Akt Signaling Contributes to Colorectal Cancer Progression

Wednesday, January 11 | 11:30AM - 2:30PM
On Own for Lunch


Wednesday, January 11 | 11:30AM - 1:00PM
Poster Setup
Room: Gallatin


Wednesday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Wednesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Therapy Resistance Mediated by Adaptive Response
s in the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 1 of 8
* Weizhou Zhang, University of Iowa, USA

Wednesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Therapy Resistance Mediated by Adaptive Response
s in the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 2 of 8
Saran Kumar, Hebrew University, Israel
Adjacency to Blood Vessels as a Generator of Tumor Cell Metabolic and Phenotypic Heterogeneities

Wednesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Therapy Resistance Mediated by Adaptive Response
s in the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 3 of 8
Mihaela Skobe, Icahn School of Medicine at Mount Sinai, USA
Lymphatic Endothelium Protects Breast Cancer Cells from Death by Inducing Metabolic Adaptations

Wednesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Therapy Resistance Mediated by Adaptive Response
s in the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 4 of 8
Melissa R. Junttila, Genentech, Inc., USA
Identification of a Non-Genomic Resistance Mechanism to Vemurafenib in a BRAF Mutant Melanoma Model

Wednesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Therapy Resistance Mediated by Adaptive Response
s in the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 5 of 8
Peter Chockley, University of Michigan Medical School, USA
EMT Confers Susceptibility to Metastasis-Specific Immune Surveillance in Lung Cancer

Wednesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Therapy Resistance Mediated by Adaptive Response
s in the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 6 of 8
Alexander Swarbrick, Garvan Institute of Medical Research, Australia
The Paracrine Hedgehog-FGF Axis Mediates Cancer Stem Cell Plasticity in Triple Negative Breast Cancer

Wednesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Therapy Resistance Mediated by Adaptive Response
s in the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 7 of 8
* Ela Elyada, Cold Spring Harbor Laboratory, USA
Pancreatic Stellate Cell Dynamics in PDAC

Wednesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Therapy Resistance Mediated by Adaptive Response
s in the Tumor Microenvironment
Room: Jefferson/Madison

Speaker 8 of 8
Michael Timaner, Technion-Israel Institute of Technology, Israel
Tumor-Associated Mesenchymal Stem Cells Preserve Cancer Stem Cells Niche in the Tumor Microenvironment Following Chemotherapy

Wednesday, January 11 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Wednesday, January 11 | 5:00PM - 7:00PM
Approaches to Visualize and Study Dynamics of the Tumor Micr
oenvironment (“Imaging”)

Room: Jefferson/Madison

Speaker 1 of 6
* Sergei Grivennikov, Fox Chase Cancer Center, USA

Wednesday, January 11 | 5:00PM - 7:00PM
Approaches to Visualize and Study Dynamics of the Tumor Micr
oenvironment (“Imaging”)

Room: Jefferson/Madison

Speaker 2 of 6
* Stefani Spranger, Massachusetts Institute of Technology, USA

Wednesday, January 11 | 5:00PM - 7:00PM
Approaches to Visualize and Study Dynamics of the Tumor Micr
oenvironment (“Imaging”)

Room: Jefferson/Madison

Speaker 3 of 6
Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Imaging Reveals Tumor and Stromal Contributions to Formation of Metastases

Wednesday, January 11 | 5:00PM - 7:00PM
Approaches to Visualize and Study Dynamics of the Tumor Micr
oenvironment (“Imaging”)

Room: Jefferson/Madison

Speaker 4 of 6
Danielle Seinstra, Hubrecht Institute, Netherlands
Plasticity Between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

Wednesday, January 11 | 5:00PM - 7:00PM
Approaches to Visualize and Study Dynamics of the Tumor Micr
oenvironment (“Imaging”)

Room: Jefferson/Madison

Speaker 5 of 6
Tracy W. Liu, MD Anderson Cancer Center, USA
Short Talk: Imaging the Dynamics of Tumor NF-kB Transcriptional Activation and the Microenvironment In Vivo

Wednesday, January 11 | 5:00PM - 7:00PM
Approaches to Visualize and Study Dynamics of the Tumor Micr
oenvironment (“Imaging”)

Room: Jefferson/Madison

Speaker 6 of 6
Matthew F. Krummel, University of California, San Francisco, USA
Imaging and Deconvolving Tumor Antigen Flow in Primary and Metastatic Tumor Sites

Wednesday, January 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Gallatin
No registration fees are used to fund alcohol served at this function.

Wednesday, January 11 | 7:30PM - 10:00PM
Poster Session 3
Room: Gallatin


Thursday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Thursday, January 12 | 8:00AM - 11:15AM
Targeting the Changing Tumor Microenvironment for Anti-Cance
r Therapies

Room: Jefferson/Madison

Speaker 1 of 10
* Andrew J. Ewald, Johns Hopkins University School of Medicine, USA

Thursday, January 12 | 8:00AM - 11:15AM
Targeting the Changing Tumor Microenvironment for Anti-Cance
r Therapies

Room: Jefferson/Madison

Speaker 2 of 10
* Sheila A. Stewart, Washington University School of Medicine, USA

Thursday, January 12 | 8:00AM - 11:15AM
Targeting the Changing Tumor Microenvironment for Anti-Cance
r Therapies

Room: Jefferson/Madison

Speaker 3 of 10
Karin E. de Visser, Netherlands Cancer Institute, Netherlands
EMBO Young Investigator Lecture: Targeting Tumor-Induced Systemic Inflammation to Fight Metastatic Breast Cancer

Thursday, January 12 | 8:00AM - 11:15AM
Targeting the Changing Tumor Microenvironment for Anti-Cance
r Therapies

Room: Jefferson/Madison

Speaker 4 of 10
Carla V. Rothlin, Yale University, USA
Innate Immune Checkpoints in Anti-Tumor Immunity

Thursday, January 12 | 8:00AM - 11:15AM
Targeting the Changing Tumor Microenvironment for Anti-Cance
r Therapies

Room: Jefferson/Madison

Speaker 5 of 10
Deepak Nagrath, University of Michigan, USA
Short Talk: Targeting Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

Thursday, January 12 | 8:00AM - 11:15AM
Targeting the Changing Tumor Microenvironment for Anti-Cance
r Therapies

Room: Jefferson/Madison


Coffee Break

Thursday, January 12 | 8:00AM - 11:15AM
Targeting the Changing Tumor Microenvironment for Anti-Cance
r Therapies

Room: Jefferson/Madison

Speaker 7 of 10
Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School, USA
Systemic Regulation of Tumor and Stromal Cell Plasticity

Thursday, January 12 | 8:00AM - 11:15AM
Targeting the Changing Tumor Microenvironment for Anti-Cance
r Therapies

Room: Jefferson/Madison

Speaker 8 of 10
Lionel J. Apetoh, Centre Georges Francois Leclerc, France
Short Talk: Selective Degradation of the PU.1 Transcription Factor by Autophagy Represses TH9 Cell Differentiation

Thursday, January 12 | 8:00AM - 11:15AM
Targeting the Changing Tumor Microenvironment for Anti-Cance
r Therapies

Room: Jefferson/Madison

Speaker 9 of 10
Paula D. Bos, Virginia Commonwealth University, USA
Short Talk: Treg-ulation of the Breast Tumor Microenvironment

Thursday, January 12 | 8:00AM - 11:15AM
Targeting the Changing Tumor Microenvironment for Anti-Cance
r Therapies

Room: Jefferson/Madison

Speaker 10 of 10
Weizhou Zhang, University of Iowa, USA
Short Talk: Obesity-Related NLRC4 Inflammasome Activation and Angiogenesis in Breast Cancer

Thursday, January 12 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Thursday, January 12 | 5:00PM - 6:15PM
Therapy Resistance Mediated by Adaptive Responses in the Tum
or Microenvironment

Room: Jefferson/Madison

Speaker 1 of 4
* Erik A. Sahai, Francis Crick Institute, UK

Thursday, January 12 | 5:00PM - 6:15PM
Therapy Resistance Mediated by Adaptive Responses in the Tum
or Microenvironment

Room: Jefferson/Madison

Speaker 2 of 4
* Karin E. de Visser, Netherlands Cancer Institute, Netherlands

Thursday, January 12 | 5:00PM - 6:15PM
Therapy Resistance Mediated by Adaptive Responses in the Tum
or Microenvironment

Room: Jefferson/Madison

Speaker 3 of 4
Francois Ghiringhelli, Centre de Recherche, INSERM U866, France
Chemotherapy and Reprogramming Immune and Cancer Cells

Thursday, January 12 | 5:00PM - 6:15PM
Therapy Resistance Mediated by Adaptive Responses in the Tum
or Microenvironment

Room: Jefferson/Madison

Speaker 4 of 4
Stefani Spranger, Massachusetts Institute of Technology, USA
Impact of Tumor Cell-Intrinsic Signaling on Anti-Tumor Immune Responses in the Tumor Microenvironment

Thursday, January 12 | 6:15PM - 7:00PM
Closing Keynote Address
Room: Jefferson/Madison

Speaker 1 of 4
* Sergei Grivennikov, Fox Chase Cancer Center, USA

Thursday, January 12 | 6:15PM - 7:00PM
Closing Keynote Address
Room: Jefferson/Madison

Speaker 2 of 4
* Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany

Thursday, January 12 | 6:15PM - 7:00PM
Closing Keynote Address
Room: Jefferson/Madison

Speaker 3 of 4
* Mikala Egeblad, Cold Spring Harbor Laboratory, USA

Thursday, January 12 | 6:15PM - 7:00PM
Closing Keynote Address
Room: Jefferson/Madison

Speaker 4 of 4
Robert A. Weinberg, Massachusetts Institute of Technology, USA
The Epithelial-Mesenchymal Transition and Malignant Progression

Thursday, January 12 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Jefferson/Madison


Thursday, January 12 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Gallatin
No registration fees are used to fund alcohol served at this function.

Thursday, January 12 | 8:00PM - 11:00PM
Entertainment
Room: Gallatin
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 12 | 8:15PM - 11:00PM
Cash Bar
Room: Gallatin


Friday, January 13 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.