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This meeting took place in the past. Here is a list of meetings that are related:
Engineering the Genome (2020Q2)
Genome Engineering: From Mechanisms to Therapies (2019B4)
Precision Genome Editing with Programmable Nucleases (2018B1)
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Web Desc
Precision Genome Engineering
Organizer(s): J. Keith Joung, Emmanuelle Charpentier and Olivier Danos
Date: January 08 - 12, 2017
Location: Beaver Run Resort, Breckenridge, CO, USA
Sponsored by Biogen, Editas Medicine, Inc., Merck & Co., Inc., Novo Nordisk A/S, Regeneron Pharmaceuticals, Inc., Sangamo Therapeutics, Inc. and Thermo Fisher Scientific Inc.
For important information on the coronavirus, please
click here
Summary of Meeting:
Precision genome engineering technologies enable targeted, highly efficient alteration of DNA sequences in living cells or organisms. Given their customizable nature, these technologies promise to be broadly useful both as biomedical research tools and as novel therapeutics for gene-based diseases. Given the rapidity with which this field moves, it is challenging for both newcomers and experts alike to stay updated with all of the latest advances. Furthermore, genome engineering necessarily encompasses a broad range of scientific expertise that includes fundamental mechanisms of DNA repair, basic science studies of bacterial-derived systems that form the basis of many of these technologies, innovations with genome engineering tool platforms, a wide variety of research applications spanning from model organisms to plants and mammalian cells, and pre-clinical and clinical studies aimed at translation into human therapeutics. The goal of this Keystone Symposia meeting is to bring together scientists from academia and industry with diverse but relevant expertise in a setting conducive to discussion of new results and potential collaborative efforts. Invited talks will cover a wide range of topics ranging from fundamental basic science through to clinical translation studies. Attendees of this meeting will have the opportunity to hear about the latest findings in this fast-paced field and to establish collaborations with scientists who have complementary expertise.
Scholarship Deadline: September 19 2016
Discounted Abstract Deadline: September 19 2016
Abstract Deadline: October 6 2016
Discounted Registration Deadline: November 9 2016
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
We gratefully acknowledge additional support for this conference from:
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
Editas Medicine, Inc.
Sangamo Therapeutics, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
Program
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Sunday, January 08
| 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer
Sunday, January 08
| 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.
Monday, January 09
| 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery
Monday, January 09
| 8:00AM - 9:00AM
Welcome & Keynote Address
Room: Colorado Ballroom
Provide an overview of ongoing clinical trials that are based on or utilize genome-editing technologies. Discuss on-going and future challenges to further translation.
Speaker 1 of 2
* J. Keith Joung
, Massachusetts General Hospital, USA
Monday, January 09
| 8:00AM - 9:00AM
Welcome & Keynote Address
Room: Colorado Ballroom
Provide an overview of ongoing clinical trials that are based on or utilize genome-editing technologies. Discuss on-going and future challenges to further translation.
Speaker 2 of 2
Luigi M. Naldini
, San Raffaele Telethon Institute, Italy
Precision Genome Engineering of Human Hematopoiesis for Treating Genetic Disease and Cancer
Monday, January 09
| 9:00AM - 11:30AM
(Basic) Science of Recombination & DNA Repair
Room: Colorado Ballroom
Speaker 1 of 7
* J. Keith Joung
, Massachusetts General Hospital, USA
Monday, January 09
| 9:00AM - 11:30AM
(Basic) Science of Recombination & DNA Repair
Room: Colorado Ballroom
Speaker 2 of 7
David R. Liu
, Broad Institute, HHMI, and Harvard University, USA
Base Editing: Genome Editing without Double-Stranded DNA Cleavage
Monday, January 09
| 9:00AM - 11:30AM
(Basic) Science of Recombination & DNA Repair
Room: Colorado Ballroom
Coffee Break
Monday, January 09
| 9:00AM - 11:30AM
(Basic) Science of Recombination & DNA Repair
Room: Colorado Ballroom
Speaker 4 of 7
Maria Jasin
, Memorial Sloan Kettering Cancer Center, USA
DNA Repair Mechanisms and Genome Engineering
Monday, January 09
| 9:00AM - 11:30AM
(Basic) Science of Recombination & DNA Repair
Room: Colorado Ballroom
Speaker 5 of 7
Frederick W. Alt
, Boston Children's Hospital, USA
Recurrent DNA Break Cluster Genes in Neural Development, Diversification and Disease: Potential Analogies to Lymphocyte Rearrangement Processes
Monday, January 09
| 9:00AM - 11:30AM
(Basic) Science of Recombination & DNA Repair
Room: Colorado Ballroom
Speaker 6 of 7
Jean-Yves Masson
, Laval University Cancer Research Center, Canada
Short Talk: Regulation of the Tumor Suppressor PALB2: A Critical Player for Homologous Recombination at a CRISPR/Cas9-Induced DNA Double-Strand Break
Monday, January 09
| 9:00AM - 11:30AM
(Basic) Science of Recombination & DNA Repair
Room: Colorado Ballroom
Speaker 7 of 7
Katherine S. Pawelczak
, NERx Biosciences, USA
Short Talk: Chemical Enhancement of CRISPR/Cas9 Mediated Site-Specific Genome Engineering using Novel Inhibitors of the Ku-DNA Interaction
Monday, January 09
| 11:30AM - 5:00PM
On Own for Lunch
Monday, January 09
| 11:30AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom
Monday, January 09
| 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom
Monday, January 09
| 2:30PM - 3:30PM
Workshop 1: In vivo Delivery of Genome Editing Nucleases
Room: Colorado Ballroom
Workshop participants will discuss outstanding issues such as mode of delivery, formulation, routes of administration, dose definition, genotoxicity and immune responses. The goal will be to define the gaps in developing genome editing reagents as injectable drugs.
Speaker 1 of 1
* Olivier Danos
, REGENXBIO Inc, USA
Monday, January 09
| 3:30PM - 4:30PM
Workshop 2: Ex vivo or in vitro Delivery of Genome Editing N
ucleases
Room: Colorado Ballroom
Speaker 1 of 1
* Luigi M. Naldini
, San Raffaele Telethon Institute, Italy
Monday, January 09
| 4:30PM - 5:00PM
Coffee Available
Room: Foyer
Monday, January 09
| 5:00PM - 7:00PM
Latest Advances in Genome-Editing Nuclease Technologies I
Room: Colorado Ballroom
Speaker 1 of 4
* J. Keith Joung
, Massachusetts General Hospital, USA
Monday, January 09
| 5:00PM - 7:00PM
Latest Advances in Genome-Editing Nuclease Technologies I
Room: Colorado Ballroom
Speaker 2 of 4
Edward J. Rebar
, Sangamo Therapeutics, Inc., USA
New Zinc Finger Nuclease Architectures for Precision Genome Engineering
Monday, January 09
| 5:00PM - 7:00PM
Latest Advances in Genome-Editing Nuclease Technologies I
Room: Colorado Ballroom
Speaker 3 of 4
Jay Ashok Shendure
, University of Washington, USA
Applications of Genome Editing in Developmental Biology and Human Genetics
Monday, January 09
| 5:00PM - 7:00PM
Latest Advances in Genome-Editing Nuclease Technologies I
Room: Colorado Ballroom
Speaker 4 of 4
Amit Choudhary
, Harvard Medical School, USA
Short Talk: Chemical Control of CRISPR-Cas9 in Cells and Organisms
Monday, January 09
| 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.
Monday, January 09
| 7:30PM - 10:00PM
Poster Session 1
Room: Breckenridge Ballroom
Tuesday, January 10
| 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery
Tuesday, January 10
| 8:00AM - 11:00AM
Latest Advances in Genome-Editing Nuclease Technologies II
Room: Colorado Ballroom
Speaker 1 of 8
* Jennifer A. Doudna
, HHMI/University of California, Berkeley, USA
Tuesday, January 10
| 8:00AM - 11:00AM
Latest Advances in Genome-Editing Nuclease Technologies II
Room: Colorado Ballroom
Speaker 2 of 8
Jonathan S. Weissman
, University of California, San Francisco, USA
Applications of CRISPR-Cas9-Based Gene Regulatory Proteins
Tuesday, January 10
| 8:00AM - 11:00AM
Latest Advances in Genome-Editing Nuclease Technologies II
Room: Colorado Ballroom
Speaker 3 of 8
Andrew May
, Sana Biotechnology, Inc., USA
DNA Repair Outcomes Following Cas9 Double-Stranded Breaks
Tuesday, January 10
| 8:00AM - 11:00AM
Latest Advances in Genome-Editing Nuclease Technologies II
Room: Colorado Ballroom
Coffee Break
Tuesday, January 10
| 8:00AM - 11:00AM
Latest Advances in Genome-Editing Nuclease Technologies II
Room: Colorado Ballroom
Speaker 5 of 8
J. Keith Joung
, Massachusetts General Hospital, USA
Defining, Optimizing and Changing the Specificities of CRISPR-Cas Nucleases
Tuesday, January 10
| 8:00AM - 11:00AM
Latest Advances in Genome-Editing Nuclease Technologies II
Room: Colorado Ballroom
Speaker 6 of 8
Rolf Turk
, Integrated DNA Technologies, USA
Short Talk: Efficient Homology-Directed Repair using Long Single-Stranded DNA Templates
Tuesday, January 10
| 8:00AM - 11:00AM
Latest Advances in Genome-Editing Nuclease Technologies II
Room: Colorado Ballroom
Speaker 7 of 8
Gurumurthy B. Channabasavaiah
, University of Nebraska Omaha, USA
Short Talk: Easi-CRISPR: A Simple and Efficient Method for Creating Reporter and Conditional Knockout Animal Models
Tuesday, January 10
| 8:00AM - 11:00AM
Latest Advances in Genome-Editing Nuclease Technologies II
Room: Colorado Ballroom
Speaker 8 of 8
Fuqiang Chen
, MilliporeSigma, USA
Short Talk: Improvement of CRISPR Activity and Specificity via Proximal Binding of Multiple CRISPR/Cas Systems (proxy-CRISPR)
Tuesday, January 10
| 11:00AM - 5:00PM
On Own for Lunch
Tuesday, January 10
| 11:00AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom
Tuesday, January 10
| 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom
Tuesday, January 10
| 2:30PM - 3:30PM
Workshop 3: Genome-Wide Specificities & Off-Target Effects o
f Genome Editing Nucleases
Room: Colorado Ballroom
This workshop will briefly review the various methods that currently exist for determining genome-wide off-target effects. Time will also be provided for a general question and answer session and discussion of best practices for off-target determination.
Speaker 1 of 1
* J. Keith Joung
, Massachusetts General Hospital, USA
Tuesday, January 10
| 3:30PM - 4:30PM
Workshop 4: Design of Individual gRNAs and Genome-Wide Libra
ries of gRNAs for CRISPR-Cas Nucleases
Room: Colorado Ballroom
This workshop will discuss what you need to know for designing guide RNAs for both small-scale experiments and genome-wide screening. We will look under the hood of available computational tools in order to understand the principles behind the choices baked into these design algorithms. Additionally, we will discuss how the 'optimal' design may vary based on model system and experimental intent.
Speaker 1 of 1
* John G. Doench
, Broad Institute of MIT and Harvard University, USA
Tuesday, January 10
| 4:30PM - 5:00PM
Coffee Available
Room: Foyer
Tuesday, January 10
| 5:00PM - 7:00PM
Biology of CRISPR Systems
Room: Colorado Ballroom
Updates on cutting-edge basic science studies of CRISPR systems. Not just Cas9 but extend to other aspects of the system (e.g., Cas1/Cas2, sequence-specific ribonucleases).
Speaker 1 of 4
* Maria Jasin
, Memorial Sloan Kettering Cancer Center, USA
Tuesday, January 10
| 5:00PM - 7:00PM
Biology of CRISPR Systems
Room: Colorado Ballroom
Updates on cutting-edge basic science studies of CRISPR systems. Not just Cas9 but extend to other aspects of the system (e.g., Cas1/Cas2, sequence-specific ribonucleases).
Speaker 2 of 4
Feng Zhang
, Broad Institute of MIT and Harvard University, USA
Expanding the CRISPR-Cas Genome Engineering Toolbox
Tuesday, January 10
| 5:00PM - 7:00PM
Biology of CRISPR Systems
Room: Colorado Ballroom
Updates on cutting-edge basic science studies of CRISPR systems. Not just Cas9 but extend to other aspects of the system (e.g., Cas1/Cas2, sequence-specific ribonucleases).
Speaker 3 of 4
Eugene V. Koonin
, National Institutes of Health, USA
Discovery of Novel CRISPR-Cas Systems by Genome and Metagenome Sequence Database Mining and Evolution of Adaptive Immunity in Prokaryotes
Tuesday, January 10
| 5:00PM - 7:00PM
Biology of CRISPR Systems
Room: Colorado Ballroom
Updates on cutting-edge basic science studies of CRISPR systems. Not just Cas9 but extend to other aspects of the system (e.g., Cas1/Cas2, sequence-specific ribonucleases).
Speaker 4 of 4
Joshua Keith Young
, Dupont Pioneer, USA
Short Talk: Identification and Characterization of Novel Cas9 Endonucleases
Tuesday, January 10
| 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.
Tuesday, January 10
| 7:30PM - 10:00PM
Poster Session 2
Room: Breckenridge Ballroom
Wednesday, January 11
| 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery
Wednesday, January 11
| 8:00AM - 11:00AM
Research Applications of Genome & Epigenome Engineering I
Room: Colorado Ballroom
Speaker 1 of 7
* Barbara J. Meyer
, University of California, Berkeley, USA
Wednesday, January 11
| 8:00AM - 11:00AM
Research Applications of Genome & Epigenome Engineering I
Room: Colorado Ballroom
Speaker 2 of 7
Angelo Lombardo
, San Raffaele Telethon Institute for Gene Therapy, Italy
Therapeutic Applications of Epigenome Editing
Wednesday, January 11
| 8:00AM - 11:00AM
Research Applications of Genome & Epigenome Engineering I
Room: Colorado Ballroom
Speaker 3 of 7
Jennifer A. Doudna
, HHMI/University of California, Berkeley, USA
Mechanism and Delivery of RNA-Guided Genome Engineering Proteins
Wednesday, January 11
| 8:00AM - 11:00AM
Research Applications of Genome & Epigenome Engineering I
Room: Colorado Ballroom
Coffee Break
Wednesday, January 11
| 8:00AM - 11:00AM
Research Applications of Genome & Epigenome Engineering I
Room: Colorado Ballroom
Speaker 5 of 7
Alister Funnell
, Altius Institute for Biomedical Sciences, USA
Short Talk: Functional Characterization of Putative Regulatory Elements by Precision Genome Engineering
Wednesday, January 11
| 8:00AM - 11:00AM
Research Applications of Genome & Epigenome Engineering I
Room: Colorado Ballroom
Speaker 6 of 7
Robert J. Ihry
, Novartis Institutes for BioMedical Research, USA
Short Talk: p53 Inhibition Enhances CRISPR/CAS9 Engineering in Human Pluripotent Stem Cells by Blocking DSB-Induced Toxicity
Wednesday, January 11
| 8:00AM - 11:00AM
Research Applications of Genome & Epigenome Engineering I
Room: Colorado Ballroom
Speaker 7 of 7
Shashank Patel
, NCI, National Institutes of Health, USA
Short Talk: A Genome-Scale CRISPR Screen to Identify Essential Genes for T Cell Based Cancer Therapies
Wednesday, January 11
| 11:00AM - 5:00PM
On Own for Lunch
Wednesday, January 11
| 11:00AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom
Wednesday, January 11
| 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom
Wednesday, January 11
| 4:30PM - 5:00PM
Coffee Available
Room: Foyer
Wednesday, January 11
| 5:00PM - 7:00PM
Research Applications of Genome & Epigenome Engineering II
Room: Colorado Ballroom
Speaker 1 of 5
* Angelo Lombardo
, San Raffaele Telethon Institute for Gene Therapy, Italy
Wednesday, January 11
| 5:00PM - 7:00PM
Research Applications of Genome & Epigenome Engineering II
Room: Colorado Ballroom
Speaker 2 of 5
Barbara J. Meyer
, University of California, Berkeley, USA
Genome Editing of C. elegans and Other Non-Model Organisms
Wednesday, January 11
| 5:00PM - 7:00PM
Research Applications of Genome & Epigenome Engineering II
Room: Colorado Ballroom
Speaker 3 of 5
Daniel F. Voytas
, University of Minnesota, USA
Precise Engineering of Plant Genomes
Wednesday, January 11
| 5:00PM - 7:00PM
Research Applications of Genome & Epigenome Engineering II
Room: Colorado Ballroom
Speaker 4 of 5
Andrea Crisanti
, Imperial College London, UK
Building and Testing CRISPR-Based Gene Drives for Population Control in the Malaria Mosquito
Wednesday, January 11
| 5:00PM - 7:00PM
Research Applications of Genome & Epigenome Engineering II
Room: Colorado Ballroom
Speaker 5 of 5
Alex Marson
, University of California, San Francisco, USA
Short Talk: Discovery of an Autoimmunity-Associated IL2RA Enhancer by Unbiased Targeting of Transcriptional Activation
Wednesday, January 11
| 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.
Wednesday, January 11
| 7:30PM - 10:00PM
Poster Session 3
Room: Breckenridge Ballroom
Thursday, January 12
| 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery
Thursday, January 12
| 8:00AM - 11:15AM
Novel Technologies for Therapeutic Application of Genome Eng
ineering
Room: Colorado Ballroom
Speaker 1 of 7
* Olivier Danos
, REGENXBIO Inc, USA
Thursday, January 12
| 8:00AM - 11:15AM
Novel Technologies for Therapeutic Application of Genome Eng
ineering
Room: Colorado Ballroom
Speaker 2 of 7
Vic E. Myer
, Atlas Ventures, USA
Advancing CRISPR Technologies for Therapeutic Application
Thursday, January 12
| 8:00AM - 11:15AM
Novel Technologies for Therapeutic Application of Genome Eng
ineering
Room: Colorado Ballroom
Speaker 3 of 7
Daniel G. Anderson
, Massachusetts Institute of Technology, USA
Nucleic Acid Delivery Systems for RNA Therapy and Gene Editing
Thursday, January 12
| 8:00AM - 11:15AM
Novel Technologies for Therapeutic Application of Genome Eng
ineering
Room: Colorado Ballroom
Coffee Break
Thursday, January 12
| 8:00AM - 11:15AM
Novel Technologies for Therapeutic Application of Genome Eng
ineering
Room: Colorado Ballroom
Speaker 5 of 7
Mark A. Kay
, Stanford University, USA
rAAV-Mediated Genome Editing without the Use of Nucleases
Thursday, January 12
| 8:00AM - 11:15AM
Novel Technologies for Therapeutic Application of Genome Eng
ineering
Room: Colorado Ballroom
Speaker 6 of 7
Bin Li
, Ohio State University, USA
Short Talk: Lipid-like Nanoparticles for mRNA Delivery in vivo
Thursday, January 12
| 8:00AM - 11:15AM
Novel Technologies for Therapeutic Application of Genome Eng
ineering
Room: Colorado Ballroom
Speaker 7 of 7
Knut Woltjen
, CiRA, Kyoto University, Japan
Short Talk: Simultaneous Derivation of Disease-Relevant Point-Mutants and Concordant Isogenic Clones from Human Induced Pluripotent Stem Cells
Thursday, January 12
| 11:15AM - 5:00PM
On Own for Lunch
Thursday, January 12
| 2:30PM - 4:30PM
Workshop 5: Ethics & Human Rights
Room: Colorado Ballroom
Speaker 1 of 3
* George J. Annas
, Boston University School of Public Health, USA
Why Precision Genome Engineering Should Not Be Used to (Try to) Make a 'Better Baby'
Thursday, January 12
| 2:30PM - 4:30PM
Workshop 5: Ethics & Human Rights
Room: Colorado Ballroom
Speaker 2 of 3
Peter Dabrock
, FAU Erlangen-Nürnberg, Germany
“Do Not Throw the Baby Out with the Bathwater” – Societal, Ethical and Governance Challenges of Precision Genome Engineering for Science and Society
Thursday, January 12
| 2:30PM - 4:30PM
Workshop 5: Ethics & Human Rights
Room: Colorado Ballroom
Speaker 3 of 3
Evelyne Shuster
, Veterans Affairs Medical Center, USA
Editing the “Book of Life”: Too Early to Prescribe?
Thursday, January 12
| 4:30PM - 5:00PM
Coffee Available
Room: Foyer
Thursday, January 12
| 5:00PM - 6:45PM
Therapeutic Applications of Genome Engineering
Room: Colorado Ballroom
Speaker 1 of 5
* Mark A. Kay
, Stanford University, USA
Thursday, January 12
| 5:00PM - 6:45PM
Therapeutic Applications of Genome Engineering
Room: Colorado Ballroom
Speaker 2 of 5
Andrew M. Scharenberg
, Casebia Therapeutics, USA
Translational Genome Editing
Thursday, January 12
| 5:00PM - 6:45PM
Therapeutic Applications of Genome Engineering
Room: Colorado Ballroom
Speaker 3 of 5
Philippe N. Duchateau
, Cellectis SA, France
TALEN®-Based Targeted Genome Modifications for Improved CAR T-Cell Adoptive Immunotherapy
Thursday, January 12
| 5:00PM - 6:45PM
Therapeutic Applications of Genome Engineering
Room: Colorado Ballroom
Speaker 4 of 5
Linhong Li
, MaxCyte, Inc., USA
Short Talk: Mutation Correction of X-linked Chronic Granulomatous Disease
Thursday, January 12
| 5:00PM - 6:45PM
Therapeutic Applications of Genome Engineering
Room: Colorado Ballroom
Speaker 5 of 5
Sateesh Krishnamurthy
, University of Iowa, USA
Short Talk: Correction of CFTR Splicing Mutation by Using CRISPR/Cas9 Genome Editing and Non-Homologous End Joining
Thursday, January 12
| 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes & Future Directions (Organizers)
Room: Colorado Ballroom
Thursday, January 12
| 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.
Thursday, January 12
| 8:00PM - 11:00PM
Entertainment
Room: Breckenridge Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources. Novo Nordisk A/S funding is not being used for this function.
Thursday, January 12
| 8:00PM - 11:00PM
Cash Bar
Room: Breckenridge Ballroom
Friday, January 13
| 10:24AM - 10:24AM
Departure
*Session Chair
†Invited, not yet responded.
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