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Web Desc
TGF-ß in Immunity, Inflammation and Cancer Organizer(s): Wanjun Chen, Joanne E. Konkel and Richard A. Flavell Date: January 09 - 13, 2017 Location: Sagebrush Inn & Suites, Taos, NM, USA Sponsored by BioLegend, Inc., EMD Serono Research and Development Institute, Inc. and Regeneron Pharmaceuticals, Inc. Summary of Meeting: TGF-beta is a key regulator of immune responses, inflammation and cancer. In addition to the well-established effects of TGF-beta on CD4+ T cell differentiation and reprogramming, TGF-beta also plays critical roles in other immune cells. Furthermore, TGF-beta has been implicated in the regulation of the interactions among immune cells, microbiota and epithelial cells. In addition to safeguarding immune homeostasis and suppressing chronic inflammation and autoimmunity, TGF-beta is emerging as a potential checkpoint in anti-tumor immunity. Despite great progress in the field, key questions related to TGF-beta functions in immune responses are still largely undetermined. Therefore, it is imperative to understand the cellular and molecular mechanisms by which TGF-beta controls such diverse immune cells. Elucidation of these pathways would allow us to understand the pathogenesis of chronic inflammation, autoimmunity and cancer and aid development of therapeutic practices in experimental and ultimately clinical settings. This meeting will gather together experts in the fields of both TGF-beta signaling and immunology to discuss new findings and update the pivotal role of TGF-beta in immunity, inflammation and cancer, with the aim to lay out the critical and key questions and outline new directions. Scholarship Deadline: September 20 2016 Discounted Abstract Deadline: September 20 2016 Abstract Deadline: October 11 2016 Discounted Registration Deadline: November 10 2016 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Eli Lilly and Company We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1R13AI126781-01 Funding for this conference was made possible (in part) by 1R13AI126781-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

TGF-ß in Immunity, Inflammation and Cancer

Organizer(s): Wanjun Chen, Joanne E. Konkel and Richard A. Flavell

Date: January 09 - 13, 2017
Location: Sagebrush Inn & Suites, Taos, NM, USA

Sponsored by BioLegend, Inc., EMD Serono Research and Development Institute, Inc. and Regeneron Pharmaceuticals, Inc.

Summary of Meeting:

TGF-beta is a key regulator of immune responses, inflammation and cancer. In addition to the well-established effects of TGF-beta on CD4+ T cell differentiation and reprogramming, TGF-beta also plays critical roles in other immune cells. Furthermore, TGF-beta has been implicated in the regulation of the interactions among immune cells, microbiota and epithelial cells. In addition to safeguarding immune homeostasis and suppressing chronic inflammation and autoimmunity, TGF-beta is emerging as a potential checkpoint in anti-tumor immunity. Despite great progress in the field, key questions related to TGF-beta functions in immune responses are still largely undetermined. Therefore, it is imperative to understand the cellular and molecular mechanisms by which TGF-beta controls such diverse immune cells. Elucidation of these pathways would allow us to understand the pathogenesis of chronic inflammation, autoimmunity and cancer and aid development of therapeutic practices in experimental and ultimately clinical settings. This meeting will gather together experts in the fields of both TGF-beta signaling and immunology to discuss new findings and update the pivotal role of TGF-beta in immunity, inflammation and cancer, with the aim to lay out the critical and key questions and outline new directions.

Scholarship Deadline: September 20 2016

Discounted Abstract Deadline: September 20 2016

Abstract Deadline: October 11 2016

Discounted Registration Deadline: November 10 2016

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Eli Lilly and Company

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI126781-01
Funding for this conference was made possible (in part) by 1R13AI126781-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Monday, January 09 \| 4:00PM - 8:00PM Arrival and Registration Room: Sagebrush Lobby & Cantina
Monday, January 09 \| 6:00PM - 8:00PM Welcome Mixer Room: Sagebrush Lobby & Cantina No registration fees are used to fund alcohol served at this function.
Tuesday, January 10 \| 7:00AM - 8:00AM Breakfast Room: Sagebrush Lobby & Cantina
Tuesday, January 10 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Chamisa Ballroom 1 Speaker 1 of 2 * Wanjun Chen, NIDCR, National Institutes of Health, USA
Tuesday, January 10 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Chamisa Ballroom 1 Speaker 2 of 2 Rik Derynck, University of California, San Francisco, USA TGF-beta Responses and Control of TGF-beta Responsiveness
Tuesday, January 10 \| 9:00AM - 11:30AM TGF-beta Superfamily: Basic Mechanisms of Signal Transductio n Room: Chamisa Ballroom 1 Speaker 1 of 7 * Howard L. Weiner, Brigham and Women’s Hospital, Harvard Medical School, USA
Tuesday, January 10 \| 9:00AM - 11:30AM TGF-beta Superfamily: Basic Mechanisms of Signal Transductio n Room: Chamisa Ballroom 1 Speaker 2 of 7 Joan Massagué, Memorial Sloan Kettering Cancer Center, USA Contextual Determinants of TGF-beta Signaling in Normal and Oncogenic Stem Cells
Tuesday, January 10 \| 9:00AM - 11:30AM TGF-beta Superfamily: Basic Mechanisms of Signal Transductio n Room: Chamisa Ballroom 1 Coffee Break
Tuesday, January 10 \| 9:00AM - 11:30AM TGF-beta Superfamily: Basic Mechanisms of Signal Transductio n Room: Chamisa Ballroom 1 Speaker 4 of 7 Stefan Karlsson, Lund University, Sweden TGF-beta Signaling in Hematopoietic Stem Cells
Tuesday, January 10 \| 9:00AM - 11:30AM TGF-beta Superfamily: Basic Mechanisms of Signal Transductio n Room: Chamisa Ballroom 1 Speaker 5 of 7 Peter ten Dijke, Leiden University Medical Center, Netherlands TGF-beta Receptor Signal Transduction in Breast Cancer
Tuesday, January 10 \| 9:00AM - 11:30AM TGF-beta Superfamily: Basic Mechanisms of Signal Transductio n Room: Chamisa Ballroom 1 Speaker 6 of 7 Aristidis Moustakas, Uppsala University, Sweden Short Talk: Epigenetic Control and Micro-RNA Processing Connect TGFBeta to EMT and Tumor Cell Stemness
Tuesday, January 10 \| 9:00AM - 11:30AM TGF-beta Superfamily: Basic Mechanisms of Signal Transductio n Room: Chamisa Ballroom 1 Speaker 7 of 7 Ying E. Zhang, NCI, National Institutes of Health, USA Short Talk: Direct Regulation of Alternative Splicing by SMAD3 is Essential to the Tumor-Promoting Role of TGF-beta
Tuesday, January 10 \| 11:30AM - 5:00PM On Own for Lunch
Tuesday, January 10 \| 11:30AM - 1:00PM Poster Setup Room: Chamisa Ballroom 2
Tuesday, January 10 \| 1:00PM - 10:00PM Poster Viewing Room: Chamisa Ballroom 2
Tuesday, January 10 \| 2:30PM - 4:30PM Workshop 1: TGF-ß in Fate Decisions and Cellular Functions Room: Chamisa Ballroom 1 Speaker 1 of 8 * Akihiko Yoshimura, Keio University, Japan
Tuesday, January 10 \| 2:30PM - 4:30PM Workshop 1: TGF-ß in Fate Decisions and Cellular Functions Room: Chamisa Ballroom 1 Speaker 2 of 8 Amina Dahmani, University of Montreal, Maisonneuve-Rosemont Hospital Research Center, Canada Transforming Growth Factor-beta Programs Central-Memory Differentiation In Ex-Vivo Stimulated Human T Cells By Modulating Id3 Expression
Tuesday, January 10 \| 2:30PM - 4:30PM Workshop 1: TGF-ß in Fate Decisions and Cellular Functions Room: Chamisa Ballroom 1 Speaker 3 of 8 Matthew Riese, Medical College of Wisconsin, USA PECAM-1, a TGF-beta Receptor Binding Protein, Contributes to CD8+ T Cell Exhaustion
Tuesday, January 10 \| 2:30PM - 4:30PM Workshop 1: TGF-ß in Fate Decisions and Cellular Functions Room: Chamisa Ballroom 1 Speaker 4 of 8 Fernando Souza-Fonseca-Guimaraes, University of Queensland, Australia TGF-beta Inhibits NK Cell Activation and Cytotoxicity through Repression of the mTOR Pathway
Tuesday, January 10 \| 2:30PM - 4:30PM Workshop 1: TGF-ß in Fate Decisions and Cellular Functions Room: Chamisa Ballroom 1 Speaker 5 of 8 Hongbo Hu, Sichuan University, China Non-Canonical NF-kappaB: The Regulating Mechanism and Application in Cancer Immunology
Tuesday, January 10 \| 2:30PM - 4:30PM Workshop 1: TGF-ß in Fate Decisions and Cellular Functions Room: Chamisa Ballroom 1 Speaker 6 of 8 Lopa Mishra, George Washington University, USA An Integrated Approach Towards Dissecting the Dichotomy of the TGF-beta Pathway in Liver Inflammation and Cancer: Insights from a Human Stem Cell Syndrome, TCGA Analyses, and Mouse Models
Tuesday, January 10 \| 2:30PM - 4:30PM Workshop 1: TGF-ß in Fate Decisions and Cellular Functions Room: Chamisa Ballroom 1 Speaker 7 of 8 Claire Gustafson, Stanford University, USA Age-Related Changes in MicroRNA Expression Alter TGF-beta Signaling in Naïve CD8 T Cells during Human Immune Aging
Tuesday, January 10 \| 2:30PM - 4:30PM Workshop 1: TGF-ß in Fate Decisions and Cellular Functions Room: Chamisa Ballroom 1 Speaker 8 of 8 Lily Huang, Regeneron Pharmaceutical, USA Inhibition of Activin A Stops the Regrowth of Surgically Resected Heterotopic Bone in a Mouse Model of Fibrodysplasia Ossificans Progressiva and Indicates a New Potential Path to Therapy
Tuesday, January 10 \| 4:30PM - 5:00PM Coffee Available Room: Chamisa Lobby
Tuesday, January 10 \| 5:00PM - 7:00PM TGF-ß in Hematopoietic Stem Cells and Innate Immunity Room: Chamisa Ballroom 1 Speaker 1 of 4 Ursula Grohmann, University of Perugia, Italy TGF-beta, Arg1, and IDO1: An Immunosuppressive Module at Work in Dendritic Cells
Tuesday, January 10 \| 5:00PM - 7:00PM TGF-ß in Hematopoietic Stem Cells and Innate Immunity Room: Chamisa Ballroom 1 Speaker 2 of 4 Herbert Strobl, Medical University Graz, Austria TGF-beta1 and BMP Signaling in Langerhans Cells
Tuesday, January 10 \| 5:00PM - 7:00PM TGF-ß in Hematopoietic Stem Cells and Innate Immunity Room: Chamisa Ballroom 1 Speaker 3 of 4 * Richard A. Flavell, HHMI/Yale University School of Medicine, USA TGF-beta Controls Th17 Plasticity and Maintains Intestinal Homeostasis
Tuesday, January 10 \| 5:00PM - 7:00PM TGF-ß in Hematopoietic Stem Cells and Innate Immunity Room: Chamisa Ballroom 1 Speaker 4 of 4 Sylvain Perruche, Etablissement Français du Sang BFC, France Short Talk: The Resolutive Factors Issued from Apoptotic Cell Clearance Allow the Termination of Ongoing Inflammation
Tuesday, January 10 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa Ballroom 2 No registration fees are used to fund alcohol served at this function.
Tuesday, January 10 \| 7:30PM - 10:00PM Poster Session 1 Room: Chamisa Ballroom 2
Wednesday, January 11 \| 7:00AM - 8:00AM Breakfast Room: Sagebrush Lobby & Cantina
Wednesday, January 11 \| 8:00AM - 11:00AM TGF-ß in T Cells I Room: Chamisa Ballroom 1 Speaker 1 of 7 * John J. O'Shea, NIAMS, National Institutes of Health, USA
Wednesday, January 11 \| 8:00AM - 11:00AM TGF-ß in T Cells I Room: Chamisa Ballroom 1 Speaker 2 of 7 Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA TGF-beta Induces Dominant Regulators that Promote Unidirectional Development of Foxp3+ Treg
Wednesday, January 11 \| 8:00AM - 11:00AM TGF-ß in T Cells I Room: Chamisa Ballroom 1 Speaker 3 of 7 Timothy A. Springer, Immune Disease Institute, Harvard University, USA A Microglia Context Molecule for TGF-beta Required for Maintenance of Nervous System Function
Wednesday, January 11 \| 8:00AM - 11:00AM TGF-ß in T Cells I Room: Chamisa Ballroom 1 Coffee Break
Wednesday, January 11 \| 8:00AM - 11:00AM TGF-ß in T Cells I Room: Chamisa Ballroom 1 Speaker 5 of 7 Wanjun Chen, NIDCR, National Institutes of Health, USA TGF-beta Regulates Tregs and Bregs
Wednesday, January 11 \| 8:00AM - 11:00AM TGF-ß in T Cells I Room: Chamisa Ballroom 1 Speaker 6 of 7 Akihiko Yoshimura, Keio University, Japan Induction of Stable TGF-ß-Mediated Regulatory T Cells by Epigenetic Modifications
Wednesday, January 11 \| 8:00AM - 11:00AM TGF-ß in T Cells I Room: Chamisa Ballroom 1 Speaker 7 of 7 Yisong Wan, University of North Carolina at Chapel Hill, USA Short Talk: TGF-beta Signaling in Controlling Diverse T Cell Functions
Wednesday, January 11 \| 11:00AM - 5:00PM On Own for Lunch
Wednesday, January 11 \| 11:00AM - 1:00PM Poster Setup Room: Chamisa Ballroom 2
Wednesday, January 11 \| 1:00PM - 10:00PM Poster Viewing Room: Chamisa Ballroom 2
Wednesday, January 11 \| 4:30PM - 5:00PM Coffee Available Room: Chamisa Lobby
Wednesday, January 11 \| 5:00PM - 7:00PM TGF-ß in T Cells II Room: Chamisa Ballroom 1 Speaker 1 of 5 * Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Wednesday, January 11 \| 5:00PM - 7:00PM TGF-ß in T Cells II Room: Chamisa Ballroom 1 Speaker 2 of 5 John J. O'Shea, NIAMS, National Institutes of Health, USA TGF-ß and MicroRNA in T Cell Plasticity
Wednesday, January 11 \| 5:00PM - 7:00PM TGF-ß in T Cells II Room: Chamisa Ballroom 1 Speaker 3 of 5 Sophie Lucas, de Duve Institute, Belgium GARP-Dependent Activation of TGF-beta1 Mediates Immunosuppression by Human and Mouse Tregs
Wednesday, January 11 \| 5:00PM - 7:00PM TGF-ß in T Cells II Room: Chamisa Ballroom 1 Speaker 4 of 5 Chen Dong, Tsinghua University, China Smad2 and Smad4 in T Cells
Wednesday, January 11 \| 5:00PM - 7:00PM TGF-ß in T Cells II Room: Chamisa Ballroom 1 Speaker 5 of 5 Zihai Li, Medical University of South Carolina, USA Short Talk: Cancer Promotion and Immune Tolerance Via A Novel gp96-GARP-TGF-beta Switch: Mechanisms and Opportunities
Wednesday, January 11 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa Ballroom 2 No registration fees are used to fund alcohol served at this function.
Wednesday, January 11 \| 7:30PM - 10:00PM Poster Session 2 Room: Chamisa Ballroom 2
Thursday, January 12 \| 7:00AM - 8:00AM Breakfast Room: Sagebrush Lobby & Cantina
Thursday, January 12 \| 8:00AM - 11:15AM TGF-ß in Emerging Immune Cells Room: Chamisa Ballroom 1 Speaker 1 of 8 * Lucienne Chatenoud, INSERM U1151, Hôpital Necker-Enfants Malades, France
Thursday, January 12 \| 8:00AM - 11:15AM TGF-ß in Emerging Immune Cells Room: Chamisa Ballroom 1 Speaker 2 of 8 Shannon J. Turley, Genentech, Inc., USA Regulation of Tumor Immunity by Stromal Cells
Thursday, January 12 \| 8:00AM - 11:15AM TGF-ß in Emerging Immune Cells Room: Chamisa Ballroom 1 Speaker 3 of 8 Yasmina Laouar, University of Michigan, USA TGF-beta in Innate Cells Matters
Thursday, January 12 \| 8:00AM - 11:15AM TGF-ß in Emerging Immune Cells Room: Chamisa Ballroom 1 Coffee Break
Thursday, January 12 \| 8:00AM - 11:15AM TGF-ß in Emerging Immune Cells Room: Chamisa Ballroom 1 Speaker 5 of 8 Joanne E. Konkel, University of Manchester, UK TGF-beta in Regulatory T Cell Function
Thursday, January 12 \| 8:00AM - 11:15AM TGF-ß in Emerging Immune Cells Room: Chamisa Ballroom 1 Speaker 6 of 8 Julien C. Marie, INSERM Cancer Research Center of Lyon, France TGF-beta Signaling in Peculiar Innate Cells
Thursday, January 12 \| 8:00AM - 11:15AM TGF-ß in Emerging Immune Cells Room: Chamisa Ballroom 1 Speaker 7 of 8 Victor S. Cortez, Washington University in St. Louis, USA Short Talk: Transforming Growth Factor-beta and Eomes Conversely Guide the Differentiation of ILC1 and NK Cells
Thursday, January 12 \| 8:00AM - 11:15AM TGF-ß in Emerging Immune Cells Room: Chamisa Ballroom 1 Speaker 8 of 8 Yuanming Xu, Pfizer, USA Short Talk: The E3 Ubiquitin Ligase Hrd1 Regulates TGF-beta Signaling Pathway to Maintain Regulatory T Cells Generation and Suppressive Function
Thursday, January 12 \| 11:15AM - 5:00PM On Own for Lunch
Thursday, January 12 \| 11:15AM - 1:00PM Poster Setup Room: Chamisa Ballroom 2
Thursday, January 12 \| 1:00PM - 10:00PM Poster Viewing Room: Chamisa Ballroom 2
Thursday, January 12 \| 4:30PM - 5:00PM Coffee Available Room: Chamisa Lobby
Thursday, January 12 \| 5:00PM - 7:00PM TGF-ß in Mucosal Immunity and in Immune Tolerance Room: Chamisa Ballroom 1 Speaker 1 of 5 * Chen Dong, Tsinghua University, China
Thursday, January 12 \| 5:00PM - 7:00PM TGF-ß in Mucosal Immunity and in Immune Tolerance Room: Chamisa Ballroom 1 Speaker 2 of 5 Howard L. Weiner, Brigham and Women’s Hospital, Harvard Medical School, USA LAP-TGF-beta Immune Cells in Mucosal Immunity, Tolerance and Cancer
Thursday, January 12 \| 5:00PM - 7:00PM TGF-ß in Mucosal Immunity and in Immune Tolerance Room: Chamisa Ballroom 1 Speaker 3 of 5 Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA A Give-and-Take Relation between TGF-beta and the Gut Environment Drives the CD4 CTL Fate
Thursday, January 12 \| 5:00PM - 7:00PM TGF-ß in Mucosal Immunity and in Immune Tolerance Room: Chamisa Ballroom 1 Speaker 4 of 5 Yingzi Cong, University of Texas Medical Branch, USA TGF-beta Regulation of Host-Microbiota Interaction at Mucosal Surface
Thursday, January 12 \| 5:00PM - 7:00PM TGF-ß in Mucosal Immunity and in Immune Tolerance Room: Chamisa Ballroom 1 Speaker 5 of 5 Mark A. Travis, University of Manchester, UK Short Talk: Human Blood Monocyte and Intestinal Macrophage Populations Regulate TGF-beta Activity via Expression of the Integrin Alphav beta8
Thursday, January 12 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa Ballroom 2 No registration fees are used to fund alcohol served at this function.
Thursday, January 12 \| 7:30PM - 10:00PM Poster Session 3 Room: Chamisa Ballroom 2
Friday, January 13 \| 7:00AM - 8:00AM Breakfast Room: Sagebrush Lobby & Cantina
Friday, January 13 \| 8:00AM - 11:15AM TGF-ß in Inflammatory Diseases: Mechanisms and Immunotherapy Room: Chamisa Ballroom 1 Speaker 1 of 7 Danielle Smyth, University of Glasgow, UK Short Talk: Identification of a Novel and Potent Mimic of TGF-beta Secreted by the Helminth Parasite Heligmosomoides Polygyrus
Friday, January 13 \| 8:00AM - 11:15AM TGF-ß in Inflammatory Diseases: Mechanisms and Immunotherapy Room: Chamisa Ballroom 1 Speaker 2 of 7 * Megan K. Levings, University of British Columbia, Canada Mechanisms of Suppression by Human Regulatory T Cells
Friday, January 13 \| 8:00AM - 11:15AM TGF-ß in Inflammatory Diseases: Mechanisms and Immunotherapy Room: Chamisa Ballroom 1 Speaker 3 of 7 Lucienne Chatenoud, INSERM U1151, Hôpital Necker-Enfants Malades, France CD3-Antibody, TGF-ß and Type I Diabetes
Friday, January 13 \| 8:00AM - 11:15AM TGF-ß in Inflammatory Diseases: Mechanisms and Immunotherapy Room: Chamisa Ballroom 1 Coffee Break
Friday, January 13 \| 8:00AM - 11:15AM TGF-ß in Inflammatory Diseases: Mechanisms and Immunotherapy Room: Chamisa Ballroom 1 Speaker 5 of 7 Lingyun Sun, Nanjing University Medical School, China TGF-beta in Mesenchymal Stem Cell-Mediated Immnoregulation in Autoimmune Diseases
Friday, January 13 \| 8:00AM - 11:15AM TGF-ß in Inflammatory Diseases: Mechanisms and Immunotherapy Room: Chamisa Ballroom 1 Speaker 6 of 7 Daniel H. Kaplan, University of Pittsburgh, USA Stromal Cells Control Epithelial Residence of Dendritic Cells and Memory T Cells through Regulated Activation of Latent TGF-b
Friday, January 13 \| 8:00AM - 11:15AM TGF-ß in Inflammatory Diseases: Mechanisms and Immunotherapy Room: Chamisa Ballroom 1 Speaker 7 of 7 Vlad Senatorov, University of California, Berkeley, USA Short Talk: Neuro-Inflammatory Astrocytic TGF-beta Signaling after Blood-Brain Barrier Disruption: A Novel Mechanism Underlying Age-Related Seizure Vulnerability and Cognitive Decline
Friday, January 13 \| 11:15AM - 5:00PM On Own for Lunch
Friday, January 13 \| 2:30PM - 4:30PM Workshop 2: TGF-ß in Inflammatory Diseases and Cancer Room: Chamisa Ballroom 1 Speaker 1 of 7 * Joanne E. Konkel, University of Manchester, UK
Friday, January 13 \| 2:30PM - 4:30PM Workshop 2: TGF-ß in Inflammatory Diseases and Cancer Room: Chamisa Ballroom 1 Speaker 2 of 7 * Lingyun Sun, Nanjing University Medical School, China
Friday, January 13 \| 2:30PM - 4:30PM Workshop 2: TGF-ß in Inflammatory Diseases and Cancer Room: Chamisa Ballroom 1 Speaker 3 of 7 Gabriela Dveksler, Uniformed Services University of the Health Sciences, USA Proteins Secreted from the Human Placenta Activate Latent TGF-b and Demonstrate Therapeutic Potential
Friday, January 13 \| 2:30PM - 4:30PM Workshop 2: TGF-ß in Inflammatory Diseases and Cancer Room: Chamisa Ballroom 1 Speaker 4 of 7 Piotr Jachimczak, RealTVac, Germany A Novel Strategy to Treat Advanced, Late-Stage Tumors with Real-Time Tumor Vaccination - RealTVac®
Friday, January 13 \| 2:30PM - 4:30PM Workshop 2: TGF-ß in Inflammatory Diseases and Cancer Room: Chamisa Ballroom 1 Speaker 5 of 7 James Gulley, NCI, National Institutes of Health, USA Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGF-beta, in Advanced Solid Tumors
Friday, January 13 \| 2:30PM - 4:30PM Workshop 2: TGF-ß in Inflammatory Diseases and Cancer Room: Chamisa Ballroom 1 Speaker 6 of 7 David F. Vincent, CRUK - Beatson Institute for Cancer Research, UK Genetic Mouse Models of Bowel Cancer Reveal the Role of TGF-beta Signaling in Intestinal Stem Cell Homeostasis and Cancer
Friday, January 13 \| 2:30PM - 4:30PM Workshop 2: TGF-ß in Inflammatory Diseases and Cancer Room: Chamisa Ballroom 1 Speaker 7 of 7 Shaopeng Yuan, Rockefeller University, USA TGF-beta Responsive Tumor Stem Cell Development and Drug Resistance in Squamous Cell Carcinoma
Friday, January 13 \| 4:30PM - 5:00PM Coffee Available Room: Chamisa Lobby
Friday, January 13 \| 5:00PM - 6:45PM TGF-ß in Cancer: Signaling in Cancer Cells and Immunotherapy for Cancer Room: Chamisa Ballroom 1 Speaker 1 of 3 * Peter ten Dijke, Leiden University Medical Center, Netherlands
Friday, January 13 \| 5:00PM - 6:45PM TGF-ß in Cancer: Signaling in Cancer Cells and Immunotherapy for Cancer Room: Chamisa Ballroom 1 Speaker 2 of 3 Lalage M. Wakefield, NCI, National Institutes of Health, USA Anti-TGF-beta Antibody Therapy: Lessons from Pre-Clinical Cancer Models
Friday, January 13 \| 5:00PM - 6:45PM TGF-ß in Cancer: Signaling in Cancer Cells and Immunotherapy for Cancer Room: Chamisa Ballroom 1 Speaker 3 of 3 Karim A. Benhadji, Eli Lilly and Company, USA Clinical Development of TGF-b Receptor Inhibitors in Cancer
Friday, January 13 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Chamisa Ballroom 1
Friday, January 13 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa Ballroom 2 No registration fees are used to fund alcohol served at this function.
Friday, January 13 \| 8:00PM - 11:00PM Entertainment Room: Chamisa Ballroom 2 Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Friday, January 13 \| 8:00PM - 11:00PM Cash Bar Room: Chamisa Ballroom 2
Saturday, January 14 \| 10:25AM - 10:25AM Departure *Session Chair.