Web Desc
Mitochondria Communication
Organizer(s): Jared Rutter, Cole M. Haynes and Marcia C. Haigis
Date: January 14 - 18, 2017
Location: Sagebrush Inn & Suites, Taos, NM, USA
Supported by the Directors Fund
Summary of Meeting:
Understanding how mitochondria communicate within the cell will provide important clues to elucidate its roles in normal cell physiology, as well as numerous diseases such as diabetes, neurodegeneration and cancer. The classical view of mitochondria is of an organelle that interacts with other features of cell biology primarily through the provision and consumption of metabolic intermediates and energetic products. Emerging evidence from many areas of science is accumulating to suggest that mitochondria play much more active roles in communication with other organelles, determining cell and organismal behavior. This conference will focus on these integrated behaviors and the resulting communication. The sessions will be organized around the different nodes, modes and destinations of that signaling. It will bring together people and ideas from different areas of cell biology and physiology who typically do not attend the same conferences, resulting in the development of new collaborations and concepts.
Scholarship Deadline: September 20 2016
Discounted Abstract Deadline: September 20 2016
Abstract Deadline: October 13 2016
Discounted Registration Deadline: November 14 2016
We gratefully acknowledge additional support for this conference from:
Seahorse Bioscience, a part of Agilent Technologies
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1R13AG054151-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 14 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sagebrush Lobby & Cantina


Saturday, January 14 | 6:00PM - 8:00PM
Welcome Mixer
Room: Sagebrush Lobby & Cantina
No registration fees are used to fund alcohol served at this function.

Sunday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Sagebrush Lobby & Cantina


Sunday, January 15 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 2
* Jared Rutter, University of Utah, USA

Sunday, January 15 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Chamisa Ballroom 1

Speaker 2 of 2
Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
Cross-Species Genetic Mapping of Targets in Mitochondria, Metabolism and Aging

Sunday, January 15 | 9:00AM - 11:30AM
Epigenetic Signaling and Regulation
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Marcia C. Haigis, Harvard Medical School, USA

Sunday, January 15 | 9:00AM - 11:30AM
Epigenetic Signaling and Regulation
Room: Chamisa Ballroom 1

Speaker 2 of 7
Eyal Gottlieb, Technion - Israel Institute of Technology, Israel
The Onco-Metabolic Role and Liabilities of the TCA Cycle in Cancer

Sunday, January 15 | 9:00AM - 11:30AM
Epigenetic Signaling and Regulation
Room: Chamisa Ballroom 1

Speaker 3 of 7
Matthew D. Hirschey, Duke University, USA
Short Talk: Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

Sunday, January 15 | 9:00AM - 11:30AM
Epigenetic Signaling and Regulation
Room: Chamisa Ballroom 1


Coffee Break

Sunday, January 15 | 9:00AM - 11:30AM
Epigenetic Signaling and Regulation
Room: Chamisa Ballroom 1

Speaker 5 of 7
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Molecular Pathogenesis of IDH Mutant Cancers

Sunday, January 15 | 9:00AM - 11:30AM
Epigenetic Signaling and Regulation
Room: Chamisa Ballroom 1

Speaker 6 of 7
Atan J. Gross, Weizmann Institute of Science, Israel
Short Talk: MTCH2: A Critical Regulator of Mitochondria Function and Communication

Sunday, January 15 | 9:00AM - 11:30AM
Epigenetic Signaling and Regulation
Room: Chamisa Ballroom 1

Speaker 7 of 7
Kathryn E. Wellen, University of Pennsylvania, USA
Linking Metabolism to DNA Damage Repair

Sunday, January 15 | 11:30AM - 5:00PM
On Own for Lunch


Sunday, January 15 | 11:30AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Sunday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Sunday, January 15 | 2:30PM - 4:30PM
Workshop 1
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Valentina Perissi, Boston University School of Medicine, USA

Sunday, January 15 | 2:30PM - 4:30PM
Workshop 1
Room: Chamisa Ballroom 1

Speaker 2 of 7
Adam L. Orr, Weill Cornell Medical College, USA
Novel Site-Specific Inhibitors of Mitochondrial ROS Production Define ROS-Mediated Events in Health and Disease

Sunday, January 15 | 2:30PM - 4:30PM
Workshop 1
Room: Chamisa Ballroom 1

Speaker 3 of 7
Amanda E. Brinker, University of Kansas Medical Center, USA
Differences in Mitochondrial Haplotype Influence Metastatic Efficiency and Expression of Related Nuclear Genes

Sunday, January 15 | 2:30PM - 4:30PM
Workshop 1
Room: Chamisa Ballroom 1

Speaker 4 of 7
Oleh Khalimonchuk, University of Nebraska, USA
Loss of Mitochondrial Protease OMA1 Alters Proliferative Properties and Promotes Metastatic Growth of Breast Cancer Cells

Sunday, January 15 | 2:30PM - 4:30PM
Workshop 1
Room: Chamisa Ballroom 1

Speaker 5 of 7
Yoshiyuki Tsujihata, Takeda Pharmaceutical Company, Ltd., Japan
Novel Approach for Exploring Small Molecule Regulators of Mitochondrial ATP under Hypoxia in Cardiomyocytes by Live Cell High Content Screening using ATP Biosensor

Sunday, January 15 | 2:30PM - 4:30PM
Workshop 1
Room: Chamisa Ballroom 1

Speaker 6 of 7
Allen Kaasik, University of Tartu, Estonia
Miro Proteins are Required for Priming Mitochondria for PINK1 Induced Parkin Translocation

Sunday, January 15 | 2:30PM - 4:30PM
Workshop 1
Room: Chamisa Ballroom 1

Speaker 7 of 7
Nicholas R. Weir, Harvard University, USA
Msp1 Antagonizes Integration of Membrane Proteins into Lipid Bilayers

Sunday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Sunday, January 15 | 5:00PM - 7:15PM
Mitochondrial/ER Communication
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Maya B. Schuldiner, Weizmann Institute of Science, Israel

Sunday, January 15 | 5:00PM - 7:15PM
Mitochondrial/ER Communication
Room: Chamisa Ballroom 1

Speaker 2 of 5
Jodi Nunnari, University of California, Davis, USA
ER/Mitochondria Contact Sites as Organizers of Mito Function

Sunday, January 15 | 5:00PM - 7:15PM
Mitochondrial/ER Communication
Room: Chamisa Ballroom 1

Speaker 3 of 5
Thomas Langer, CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Function

Sunday, January 15 | 5:00PM - 7:15PM
Mitochondrial/ER Communication
Room: Chamisa Ballroom 1

Speaker 4 of 5
Luca Scorrano, University of Padova, Italy
Unbiased Genetic and Proteomic Screenings Unveil the Mitochondria-Endoplasmic Reticulum Contacts Machinery

Sunday, January 15 | 5:00PM - 7:15PM
Mitochondrial/ER Communication
Room: Chamisa Ballroom 1

Speaker 5 of 5
György Hajnóczky, Thomas Jefferson University, USA
Calcium and ROS Regulation at the ER-Mitochondrial Interface

Sunday, January 15 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
No registration fees are used to fund alcohol served at this function.

Sunday, January 15 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Monday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Sagebrush Lobby & Cantina


Monday, January 16 | 8:00AM - 11:00AM
ROS Signaling
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Adam L. Hughes, University of Utah, USA

Monday, January 16 | 8:00AM - 11:00AM
ROS Signaling
Room: Chamisa Ballroom 1

Speaker 2 of 7
Navdeep S. Chandel, Northwestern University, USA
Mitochondria as Signaling Organelles

Monday, January 16 | 8:00AM - 11:00AM
ROS Signaling
Room: Chamisa Ballroom 1

Speaker 3 of 7
Gerald S. Shadel, The Salk Institute for Biological Studies, USA
Adaptive Responses to Mitochondrial Stress

Monday, January 16 | 8:00AM - 11:00AM
ROS Signaling
Room: Chamisa Ballroom 1

Speaker 4 of 7
Heide Christine Patterson, Whitehead Institute, USA
Short Talk: Mitochondrial ROS-Induced Syk Signaling Mediates Brown Adipocyte Development and Thermogenesis

Monday, January 16 | 8:00AM - 11:00AM
ROS Signaling
Room: Chamisa Ballroom 1


Coffee Break

Monday, January 16 | 8:00AM - 11:00AM
ROS Signaling
Room: Chamisa Ballroom 1

Speaker 6 of 7
Heinrich Jasper, Genentech, Inc., USA
Mitochondrial Stress Signaling, Stem Cells and Lifespan Extension: Lessons from Drosophila

Monday, January 16 | 8:00AM - 11:00AM
ROS Signaling
Room: Chamisa Ballroom 1

Speaker 7 of 7
Danica Chen, University of California, Berkeley, USA
Mitochondrial UPR-Mediated Metabolic Checkpoint, Stem Cell Aging and Rejuvenation

Monday, January 16 | 11:00AM - 12:00PM
NIH Funding Opportunities for Mitochondrial Research: Conver
sation with an NCI Program Officer
Room: Chamisa Ballroom 1

Speaker 1 of 1
Michael Graham Espey, NCI, National Institutes of Health, USA

Monday, January 16 | 12:00PM - 5:00PM
On Own for Lunch


Monday, January 16 | 12:00PM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Monday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Monday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Monday, January 16 | 5:00PM - 7:00PM
Mitochondria/Lysosome Communication
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Oleh Khalimonchuk, University of Nebraska, USA

Monday, January 16 | 5:00PM - 7:00PM
Mitochondria/Lysosome Communication
Room: Chamisa Ballroom 1

Speaker 2 of 4
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Amino Acid Sensing and Mitochondrial Function

Monday, January 16 | 5:00PM - 7:00PM
Mitochondria/Lysosome Communication
Room: Chamisa Ballroom 1

Speaker 3 of 4
Adam L. Hughes, University of Utah, USA
Pathways of Mitochondria-Lysosome Crosstalk

Monday, January 16 | 5:00PM - 7:00PM
Mitochondria/Lysosome Communication
Room: Chamisa Ballroom 1

Speaker 4 of 4
Maya B. Schuldiner, Weizmann Institute of Science, Israel
Keeping in Touch – Discovering and Characterizing New Contact Sites between Organelles


Monday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
No registration fees are used to fund alcohol served at this function.

Monday, January 16 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Tuesday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Sagebrush Lobby & Cantina


Tuesday, January 17 | 8:00AM - 11:00AM
Communicating Mitochondrial Dysfunction
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Heidi M. McBride, McGill University, Canada

Tuesday, January 17 | 8:00AM - 11:00AM
Communicating Mitochondrial Dysfunction
Room: Chamisa Ballroom 1

Speaker 2 of 7
Cole M. Haynes, University of Massachusetts Medical School, USA
Preferential Propagation of Toxic mtDNAs by the UPRmt

Tuesday, January 17 | 8:00AM - 11:00AM
Communicating Mitochondrial Dysfunction
Room: Chamisa Ballroom 1

Speaker 3 of 7
Marcia C. Haigis, Harvard Medical School, USA
Mitochondrial Sirtuin Networks

Tuesday, January 17 | 8:00AM - 11:00AM
Communicating Mitochondrial Dysfunction
Room: Chamisa Ballroom 1

Speaker 4 of 7
Sebastien Herzig, The Salk Institute for Biological Studies, USA
Short Talk: Regulation of Mitochondrial Dynamics by AMPK

Tuesday, January 17 | 8:00AM - 11:00AM
Communicating Mitochondrial Dysfunction
Room: Chamisa Ballroom 1


Coffee Break

Tuesday, January 17 | 8:00AM - 11:00AM
Communicating Mitochondrial Dysfunction
Room: Chamisa Ballroom 1

Speaker 6 of 7
Matt Kaeberlein, University of Washington, USA
Mechanisms Linking Severe Mitochondrial Disease and Normative Aging

Tuesday, January 17 | 8:00AM - 11:00AM
Communicating Mitochondrial Dysfunction
Room: Chamisa Ballroom 1

Speaker 7 of 7
Jared Rutter, University of Utah, USA
Stress Responsive Mitochondrial Protein Degradation

Tuesday, January 17 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, January 17 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Tuesday, January 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Tuesday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Tuesday, January 17 | 5:00PM - 7:00PM
Mitochondria and Inter-Cellular Communication
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Cole M. Haynes, University of Massachusetts Medical School, USA

Tuesday, January 17 | 5:00PM - 7:00PM
Mitochondria and Inter-Cellular Communication
Room: Chamisa Ballroom 1

Speaker 2 of 5
William B. Mair, Harvard School of Public Health, USA
Mitochondrial Plasticity Is Required for AMPK-Mediated Longevity


Tuesday, January 17 | 5:00PM - 7:00PM
Mitochondria and Inter-Cellular Communication
Room: Chamisa Ballroom 1

Speaker 3 of 5
Michael Ristow, Swiss Federal Institute of Technology Zurich - ETH, Switzerland
Mitochondrial Control of Healthy Aging

Tuesday, January 17 | 5:00PM - 7:00PM
Mitochondria and Inter-Cellular Communication
Room: Chamisa Ballroom 1

Speaker 4 of 5
Heidi M. McBride, McGill University, Canada
The Cell Biology of Metabolic Flux

Tuesday, January 17 | 5:00PM - 7:00PM
Mitochondria and Inter-Cellular Communication
Room: Chamisa Ballroom 1

Speaker 5 of 5
Meng C. Wang, Baylor College of Medicine/HHMI, USA
Short Talk: Microbes Tune Mitochondrial Dynamics to Regulate Host Metabolic Adaptation to Environmental Variations

Tuesday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
No registration fees are used to fund alcohol served at this function.

Tuesday, January 17 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 2


Wednesday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Sagebrush Lobby & Cantina


Wednesday, January 18 | 8:00AM - 11:00AM
Mitochondria and Fuel Catabolism
Room: Chamisa Ballroom 1

Speaker 1 of 6
Sheng Tony Hui, Princeton University, USA
Exchange of Mitochondrial Substrates Between Tissues

Wednesday, January 18 | 8:00AM - 11:00AM
Mitochondria and Fuel Catabolism
Room: Chamisa Ballroom 1

Speaker 2 of 6
Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Mitochondrial Metabolism and its Importance in Health and Disease

Wednesday, January 18 | 8:00AM - 11:00AM
Mitochondria and Fuel Catabolism
Room: Chamisa Ballroom 1

Speaker 3 of 6
Désirée Schatton, University of Cologne, Germany
Short Talk: The RNA-Binding Protein CLUH is a Master Regulator of Mitochondrial Catabolic Programme Activated upon Nutrient Deprivation

Wednesday, January 18 | 8:00AM - 11:00AM
Mitochondria and Fuel Catabolism
Room: Chamisa Ballroom 1


Coffee Break

Wednesday, January 18 | 8:00AM - 11:00AM
Mitochondria and Fuel Catabolism
Room: Chamisa Ballroom 1

Speaker 5 of 6
* Dave Pagliarini, Washington University in St. Louis, USA
Short Talk: Diverse Mitochondrial Protein Functions Revealed by Multi-Omic Mass Spectrometry Profiling

Wednesday, January 18 | 8:00AM - 11:00AM
Mitochondria and Fuel Catabolism
Room: Chamisa Ballroom 1

Speaker 6 of 6
Benjamin Tu, University of Texas Southwestern Medical Center, USA
Adaptive Catabolism during Cell Proliferation

Wednesday, January 18 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2
Room: Chamisa Ballroom 1

Speaker 1 of 8
* Danica Chen, University of California, Berkeley, USA

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2
Room: Chamisa Ballroom 1

Speaker 2 of 8
Yi Zhang, NHLBI, National Institutes of Health, USA
Selective Protein Synthesis on the Mitochondrial Surface Drives the mtDNA Selection

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2
Room: Chamisa Ballroom 1

Speaker 3 of 8
Anna M. Schulz, Memorial Sloan Kettering Cancer Center, USA
Gcn2-Mediated Mitochondria Protection during Metabolic Stress

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2
Room: Chamisa Ballroom 1

Speaker 4 of 8
Jonathan Van Vranken, University of Utah School of Medicine, USA
FASII Activates Oxidative Metabolism in Mitochondria via ACP Acylation

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2
Room: Chamisa Ballroom 1

Speaker 5 of 8
Jessica B. Spinelli, Harvard University, USA
Evaluating the Effect of Ammonium on Cancer Cell Homeostasis

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2
Room: Chamisa Ballroom 1

Speaker 6 of 8
Laurent Le Cam, Institut de Recherche en Cancérologie de Montpellier, France
The MDM2 Oncoprotein Controls Complex I Activity and Mitochondrial Dynamics Independently of p53

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2
Room: Chamisa Ballroom 1

Speaker 7 of 8
Martin Ott, Stockholm University, Sweden
Modulation of Cellular Stress Signaling and Aging by Changes in Mitochondrial Translation Accuracy

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2
Room: Chamisa Ballroom 1

Speaker 8 of 8
Veena Prahlad, University of Iowa, USA
Mitochondria-Regulated Immune Pathway in C. elegans is Neuroprotective

Wednesday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, January 18 | 5:00PM - 7:15PM
Coordination of Mitochondrial Mass and Physiology
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Kathryn E. Wellen, University of Pennsylvania, USA

Wednesday, January 18 | 5:00PM - 7:15PM
Coordination of Mitochondrial Mass and Physiology
Room: Chamisa Ballroom 1

Speaker 2 of 6
J. Wade Harper, Harvard Medical School, USA
Digitizing Ubiquitin Signaling for Mitophagy

Wednesday, January 18 | 5:00PM - 7:15PM
Coordination of Mitochondrial Mass and Physiology
Room: Chamisa Ballroom 1

Speaker 3 of 6
Maulik Patel, Vanderbilt University, USA
Short Talk: Homeostatic Stress Responses Regulate Selfish Mitochondrial Genome Dynamics

Wednesday, January 18 | 5:00PM - 7:15PM
Coordination of Mitochondrial Mass and Physiology
Room: Chamisa Ballroom 1

Speaker 4 of 6
Richard J. Youle, NINDS, National Institutes of Health, USA
Mitophagy Regulation

Wednesday, January 18 | 5:00PM - 7:15PM
Coordination of Mitochondrial Mass and Physiology
Room: Chamisa Ballroom 1

Speaker 5 of 6
Valentina Perissi, Boston University School of Medicine, USA
Short Talk: Regulation of Mitochondrial Biogenesis through Mitochondria Retrograde Signaling and Chromatin Remodeling of Nuclear-Encoded Mitochondrial Genes

Wednesday, January 18 | 5:00PM - 7:15PM
Coordination of Mitochondrial Mass and Physiology
Room: Chamisa Ballroom 1

Speaker 6 of 6
Nektarios N. Tavernarakis, Foundation for Research and Technology-Hellas, Greece
Mitochondrial Turnover and Homeostasis during Aging

Wednesday, January 18 | 7:15PM - 7:30PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Chamisa Ballroom 1


Wednesday, January 18 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
No registration fees are used to fund alcohol served at this function.

Wednesday, January 18 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Wednesday, January 18 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Thursday, January 19 | 10:25AM - 10:25AM
Departure


*Session Chair.