Web Desc
New Developments in Our Basic Understanding of Tuberculosis
Organizer(s): Samuel M. Behar and Valerie Mizrahi
Date: January 14 - 18, 2017
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation.
Summary of Meeting:
As a contagious disease, tuberculosis remains endemic in many countries and among vulnerable populations. In these settings, it is a major cause of morbidity and mortality. During the past two decades, there has been a renewed effort to develop vaccines and new antibiotics. However, new discoveries that have transformed our understanding of host susceptibility, immunity and disease pathogenesis have not kept pace with the progress of clinical trials. There is a need for new approaches that can limit the impact of tuberculosis around the world. This symposium will focus on fundamental questions about the host-pathogen interaction, bringing together scientists working on the bacterium and the host in model systems, as well as those trying to address basic questions in human immunology and disease. While answering these questions may not be a prerequisite to clinical progress, an improved mechanistic understanding of the survival and subversion strategies that Mycobacterium tuberculosis employs to evade therapy and host immunity will facilitate development of better strategies to treat and prevent tuberculosis. Specifically, the goals of the meeting are to: 1) Articulate a set of priority questions and goals to guide a basic research agenda for the field; 2) Integrate successful approaches employed by leading scientists in other fields that can address knowledge gaps in immunity to tuberculosis; 3) Highlight new technical advances that make possible more sophisticated human experimental biology including defining the critical questions that need to be answered to expedite clinical advances.
Global Health Travel Award Deadline: August 16 2016
Scholarship Deadline: September 21 2016
Discounted Abstract Deadline: September 21 2016
Abstract Deadline: October 18 2016
Discounted Registration Deadline: November 15 2016
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

EMBO Young Investigator Programme
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI126784-01
Funding for this conference was made possible (in part) by 1 R13 AI 126784 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 14 | 4:00PM - 8:00PM
Arrival and Registration
Room: British/Columbia Foyer


Saturday, January 14 | 6:00PM - 8:00PM
Welcome Mixer
Room: British/Columbia Foyer
No registration fees are used to fund alcohol served at this function.

Sunday, January 15 | 7:30AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Sunday, January 15 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: British/Columbia Ballroom

Speaker 1 of 3
* Samuel M. Behar, University of Massachusetts Medical School, USA

Sunday, January 15 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: British/Columbia Ballroom

Speaker 2 of 3
* Valerie Mizrahi, University of Cape Town, South Africa

Sunday, January 15 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: British/Columbia Ballroom

Speaker 3 of 3
Mark M. Davis, Stanford University School of Medicine, USA
The Pursuit of Basic Human Immunology

Sunday, January 15 | 9:30AM - 12:00PM
Bacterial Evasion of Immunity
Room: British/Columbia Ballroom

Speaker 1 of 7
* Larry S. Schlesinger, Texas Biomedical Research Institute, USA

Sunday, January 15 | 9:30AM - 12:00PM
Bacterial Evasion of Immunity
Room: British/Columbia Ballroom

Speaker 2 of 7
Carl F. Nathan, Weill Cornell Medical College, USA
Overcoming Phenotypic Tolerance of Mycobacterium Tuberculosis

Sunday, January 15 | 9:30AM - 12:00PM
Bacterial Evasion of Immunity
Room: British/Columbia Ballroom


Coffee Break

Sunday, January 15 | 9:30AM - 12:00PM
Bacterial Evasion of Immunity
Room: British/Columbia Ballroom

Speaker 4 of 7
Carolyn R. Bertozzi, Stanford University, USA
Bioorthogonal Chemistry to Probe Host-Pathogen Interactions

Sunday, January 15 | 9:30AM - 12:00PM
Bacterial Evasion of Immunity
Room: British/Columbia Ballroom

Speaker 5 of 7
Vojo Deretic, University of New Mexico Health Sciences Center, USA
The Cell Biology of the Host-Pathogen Interaction: Autophagy and Mtb

Sunday, January 15 | 9:30AM - 12:00PM
Bacterial Evasion of Immunity
Room: British/Columbia Ballroom

Speaker 6 of 7
Volker Briken, University of Maryland, USA
Short Talk: The Cell Wall Lipid PDIM Mediates Phagosomal Escape and Host Cell Exit of Mycobacterium Tuberculosis

Sunday, January 15 | 9:30AM - 12:00PM
Bacterial Evasion of Immunity
Room: British/Columbia Ballroom

Speaker 7 of 7
Chiara Toniolo, Swiss Federal Institute of Technology in Lausanne, Switzerland
Short Talk: Cell-to-Cell Phenotypic Heterogeneity in the Interactions between Macrophages and Mycobacterium Tuberculosis

Sunday, January 15 | 12:00PM - 2:30PM
On Own for Lunch


Sunday, January 15 | 12:00PM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Sunday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Sunday, January 15 | 2:30PM - 4:30PM
Workshop: Human Immunology
Room: British/Columbia Ballroom

Speaker 1 of 8
* Thomas J. Scriba, University of Cape Town, South Africa

Sunday, January 15 | 2:30PM - 4:30PM
Workshop: Human Immunology
Room: British/Columbia Ballroom

Speaker 2 of 8
Malika Davids, University of Cape Town, South Africa
A Human Lung-Orientated Approach to Correlates of Risk in Tuberculosis

Sunday, January 15 | 2:30PM - 4:30PM
Workshop: Human Immunology
Room: British/Columbia Ballroom

Speaker 3 of 8
Baoxue Ge, Shanghai Pulmonary Hospital, Tongji University School of Medicine, China
Genetic Susceptibility for Tuberculosis

Sunday, January 15 | 2:30PM - 4:30PM
Workshop: Human Immunology
Room: British/Columbia Ballroom

Speaker 4 of 8
Carolin Turner, University College London, UK
Transcriptional T Cell Subset Signatures to Dissect the Human Tissue Response in Tuberculosis

Sunday, January 15 | 2:30PM - 4:30PM
Workshop: Human Immunology
Room: British/Columbia Ballroom

Speaker 5 of 8
Sharee Ann Basdeo, Trinity Translational Medicine Institute, Ireland
The Shift to Warburg Metabolism in M. Tuberculosis-Infected Human Macrophages Directs Subsequent Adaptive T Cell Responses

Sunday, January 15 | 2:30PM - 4:30PM
Workshop: Human Immunology
Room: British/Columbia Ballroom

Speaker 6 of 8
Cecilia S. Lindestam Arlehamn, La Jolla Institute for Allergy and Immunology, USA
Differential Recognition of MTB-Specific Epitopes as a Function of Treatment

Sunday, January 15 | 2:30PM - 4:30PM
Workshop: Human Immunology
Room: British/Columbia Ballroom

Speaker 7 of 8
Steven G. Smith, London School of Hygiene and Tropical Medicine, UK
BCG-Induced Trained Immunity Profiling in Infants Identifies Epidermal Growth Factor, Interleukin-6 and Platelet-Derived Growth Factor-AA/AB as Biomarkers

Sunday, January 15 | 2:30PM - 4:30PM
Workshop: Human Immunology
Room: British/Columbia Ballroom

Speaker 8 of 8
Patrizia Amelio, Centre Hospitalier Universitaire Vaudois, Switzerland
Skewed Th2 Functional Profile of Mycobacterium Tuberculosis-Specific CD4 T Cells in Patients with Active Tuberculosis from Helminth Endemic Area

Sunday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Sunday, January 15 | 5:00PM - 7:00PM
How Infected Macrophages Kill Mtb
Room: British/Columbia Ballroom

Speaker 1 of 5
* Joel D. Ernst, University of California, San Francisco, USA

Sunday, January 15 | 5:00PM - 7:00PM
How Infected Macrophages Kill Mtb
Room: British/Columbia Ballroom

Speaker 2 of 5
Maziar Divangahi, McGill University, Canada
How to Win Against TB: Host Resistance Versus Host Tolerance


Sunday, January 15 | 5:00PM - 7:00PM
How Infected Macrophages Kill Mtb
Room: British/Columbia Ballroom

Speaker 3 of 5
Larry S. Schlesinger, Texas Biomedical Research Institute, USA
Linking M. tuberculosis Recognition with Human Macrophage Defense Functions

Sunday, January 15 | 5:00PM - 7:00PM
How Infected Macrophages Kill Mtb
Room: British/Columbia Ballroom

Speaker 4 of 5
Brian C. VanderVen, Cornell University, USA
Lipid Assimilation by M. Tuberculosis

Sunday, January 15 | 5:00PM - 7:00PM
How Infected Macrophages Kill Mtb
Room: British/Columbia Ballroom

Speaker 5 of 5
Matthew Knight, University of California, Berkeley, USA
Short Talk: Macrophage Lipid Droplet Formation is Mediated by HIF-1alpha during TB Infection

Sunday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Sunday, January 15 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Monday, January 16 | 7:30AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Monday, January 16 | 8:30AM - 11:45AM
T Cell Immunity
Room: British/Columbia Ballroom

Speaker 1 of 8
* Andrea M. Cooper, University of Leicester, UK

Monday, January 16 | 8:30AM - 11:45AM
T Cell Immunity
Room: British/Columbia Ballroom

Speaker 2 of 8
Samuel M. Behar, University of Massachusetts Medical School, USA
The Role of IL-21 in Protective Immunity to TB

Monday, January 16 | 8:30AM - 11:45AM
T Cell Immunity
Room: British/Columbia Ballroom

Speaker 3 of 8
Jeroen W. van Heijst, Neogene Therapeutics, Netherlands
T Cell-Intrinsic Limitations in the Recognition of Mycobacterium tuberculosis

Monday, January 16 | 8:30AM - 11:45AM
T Cell Immunity
Room: British/Columbia Ballroom


Coffee Break

Monday, January 16 | 8:30AM - 11:45AM
T Cell Immunity
Room: British/Columbia Ballroom

Speaker 5 of 8
Chyung-Ru Wang, Northwestern University Feinberg School of Medicine, USA
Group1 CD1-Restricted T Cells in Mycobacterium Tuberculosis Infection

Monday, January 16 | 8:30AM - 11:45AM
T Cell Immunity
Room: British/Columbia Ballroom

Speaker 6 of 8
Thomas J. Scriba, University of Cape Town, South Africa
Differentiation and Function of M. tuberculosis-Specific CD4 T Cells: Implications for TB Vaccine Design

Monday, January 16 | 8:30AM - 11:45AM
T Cell Immunity
Room: British/Columbia Ballroom

Speaker 7 of 8
David M. Lewinsohn, Oregon Health & Science University, USA
Short Talk: Analysis of the MR1 Ligandome from Mycobacterially-Infected Cells Reveals Unexpected Diversity and is Associated with Discrete TCR Recognition

Monday, January 16 | 8:30AM - 11:45AM
T Cell Immunity
Room: British/Columbia Ballroom

Speaker 8 of 8
Justin Greene, Oregon Health and Science University, USA
Short Talk: MR1 Restricted Mucosal-Associated Invariant T (MAIT) Cells Respond to Mycobacterial Vaccination and Infection in Nonhuman Primates

Monday, January 16 | 11:45AM - 5:00PM
On Own for Lunch


Monday, January 16 | 11:45AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Monday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Monday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Monday, January 16 | 5:00PM - 7:00PM
Failure of T Cell Immunity
Room: British/Columbia Ballroom

Speaker 1 of 5
* David M. Lewinsohn, Oregon Health & Science University, USA

Monday, January 16 | 5:00PM - 7:00PM
Failure of T Cell Immunity
Room: British/Columbia Ballroom

Speaker 2 of 5
Joel D. Ernst, University of California, San Francisco, USA
Mycobacterial Evasion of CD4 T Cell Recognition and Activation

Monday, January 16 | 5:00PM - 7:00PM
Failure of T Cell Immunity
Room: British/Columbia Ballroom

Speaker 3 of 5
Daniel L. Barber, NIAID, National Institutes of Health, USA
Protective and Non-Protective CD4 T Cell Responses Against M. tuberculosis Infection

Monday, January 16 | 5:00PM - 7:00PM
Failure of T Cell Immunity
Room: British/Columbia Ballroom

Speaker 4 of 5
Anne O'Garra, Francis Crick Institute, UK
IL-10 and T Cell Inhibition

Monday, January 16 | 5:00PM - 7:00PM
Failure of T Cell Immunity
Room: British/Columbia Ballroom

Speaker 5 of 5
Shannon L. Russell, African Health Research Institute, South Africa
Short Talk: Metabolic Reprogramming during Chronic Mycobacterium Tuberculosis Infection Promotes Maladaptive T Cell Responses and Exhaustion

Monday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, January 16 | 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom


Tuesday, January 17 | 7:30AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Tuesday, January 17 | 8:30AM - 11:45AM
The Genetics of Host-Pathogen Interactions
Room: British/Columbia Ballroom

Speaker 1 of 8
* Sabine Ehrt, Weill Cornell Medical College, USA

Tuesday, January 17 | 8:30AM - 11:45AM
The Genetics of Host-Pathogen Interactions
Room: British/Columbia Ballroom

Speaker 2 of 8
Erwin Schurr, Research Institute of the McGill University Health Centre, Canada
Human Genetics of Tuberculosis Infection and Disease

Tuesday, January 17 | 8:30AM - 11:45AM
The Genetics of Host-Pathogen Interactions
Room: British/Columbia Ballroom

Speaker 3 of 8
Clare M. Smith, University of Massachusetts Medical School, USA
Systems Genetics of the Host-Pathogen Interaction

Tuesday, January 17 | 8:30AM - 11:45AM
The Genetics of Host-Pathogen Interactions
Room: British/Columbia Ballroom


Coffee Break

Tuesday, January 17 | 8:30AM - 11:45AM
The Genetics of Host-Pathogen Interactions
Room: British/Columbia Ballroom

Speaker 5 of 8
Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA
Scents and Scentsibility

Tuesday, January 17 | 8:30AM - 11:45AM
The Genetics of Host-Pathogen Interactions
Room: British/Columbia Ballroom

Speaker 6 of 8
David M. Tobin, Duke University School of Medicine, USA
Genetics of Mycobacterial Dissemination and Bone Disease

Tuesday, January 17 | 8:30AM - 11:45AM
The Genetics of Host-Pathogen Interactions
Room: British/Columbia Ballroom

Speaker 7 of 8
Amy K. Barczak, Massachusetts General Hospital, USA
Short Talk: Unraveling Mtb Strategies for Intracellular Survival by Combined Analysis of Host and Pathogen Phenotypes

Tuesday, January 17 | 8:30AM - 11:45AM
The Genetics of Host-Pathogen Interactions
Room: British/Columbia Ballroom

Speaker 8 of 8
Mark R. Cronan, Duke University, USA
Short Talk: Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection

Tuesday, January 17 | 11:45AM - 12:45PM
Grantsmanship Workshop presented by NIAID
Room: British/Columbia Ballroom
NIAID Workshop Objectives:

Come find out what happens to your applications after you submit it to the NIH. NIAID staff will provide attendees with an overview of NIH peer-review, and provide some grantsmanship tips. NIAID Program Officers and Scientific Review Officers will explain their role in shepherding your grants/proposals through the process. Staff will also provide attendees with resources that will alert them to NIAID funding opportunities and discuss specific opportunities targeted to research in mycobacterial diseases. Finally, time permitting staff will discuss various career opportunities within the NIH.


Tuesday, January 17 | 11:45AM - 5:00PM
On Own for Lunch


Tuesday, January 17 | 11:45AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Tuesday, January 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Tuesday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Tuesday, January 17 | 5:00PM - 7:00PM
Biology at the Host Pathogen Interface
Room: British/Columbia Ballroom

Speaker 1 of 5
* Valerie Mizrahi, University of Cape Town, South Africa

Tuesday, January 17 | 5:00PM - 7:00PM
Biology at the Host Pathogen Interface
Room: British/Columbia Ballroom

Speaker 2 of 5
Priscille Marie Brodin, CIIL Institut Pasteur, France
EMBO Young Investigator Lecture: Cellular Players Involved in Survival of Phagosomal Mycobacterium Tuberculosis

Tuesday, January 17 | 5:00PM - 7:00PM
Biology at the Host Pathogen Interface
Room: British/Columbia Ballroom

Speaker 3 of 5
Clifford V. Harding, Case Western Reserve University, USA
Mycobacterium tuberculosis (Mtb) Regulation of Immune Responses via Toll-Like Receptor 2 (TLR2)-Dependent ERK Signaling and Potential Roles of Lipoglycans in Immune Evasion

Tuesday, January 17 | 5:00PM - 7:00PM
Biology at the Host Pathogen Interface
Room: British/Columbia Ballroom

Speaker 4 of 5
Paul T. Elkington, University of Southampton, UK
Studying the Host-Pathogen Interaction in a 3-Dimensional Bioengineered Human Cell Culture Model

Tuesday, January 17 | 5:00PM - 7:00PM
Biology at the Host Pathogen Interface
Room: British/Columbia Ballroom

Speaker 5 of 5
Rustin Lovewell, University of Massachusetts Medical School, USA
Short Talk: The Relationship between Neutrophils and Mycobacterium tuberculosis in Different Disease States

Tuesday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, January 17 | 7:30PM - 10:00PM
Poster Session 3
Room: Pacific Ballroom


Wednesday, January 18 | 7:30AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Wednesday, January 18 | 8:30AM - 11:45AM
T Cell Memory: A Prerequisite to Vaccine Efficacy
Room: British/Columbia Ballroom

Speaker 1 of 8
* Samuel M. Behar, University of Massachusetts Medical School, USA

Wednesday, January 18 | 8:30AM - 11:45AM
T Cell Memory: A Prerequisite to Vaccine Efficacy
Room: British/Columbia Ballroom

Speaker 2 of 8
Andrea M. Cooper, University of Leicester, UK
T Cell Memory to TB – Do We Know What We Want? Do We Know How to Get It?

Wednesday, January 18 | 8:30AM - 11:45AM
T Cell Memory: A Prerequisite to Vaccine Efficacy
Room: British/Columbia Ballroom

Speaker 3 of 8
David B. Masopust, University of Minnesota, USA
Resident Memory T Cells

Wednesday, January 18 | 8:30AM - 11:45AM
T Cell Memory: A Prerequisite to Vaccine Efficacy
Room: British/Columbia Ballroom


Coffee Break

Wednesday, January 18 | 8:30AM - 11:45AM
T Cell Memory: A Prerequisite to Vaccine Efficacy
Room: British/Columbia Ballroom

Speaker 5 of 8
Stephen M. Carpenter, Regeneron Pharmaceuticals, USA
Dysfunction of Memory T Cells during Infection

Wednesday, January 18 | 8:30AM - 11:45AM
T Cell Memory: A Prerequisite to Vaccine Efficacy
Room: British/Columbia Ballroom

Speaker 6 of 8
Jacqueline M. Achkar, Albert Einstein College of Medicine, USA
Protective Roles of Antibodies in M. tuberculosis Infection

Wednesday, January 18 | 8:30AM - 11:45AM
T Cell Memory: A Prerequisite to Vaccine Efficacy
Room: British/Columbia Ballroom

Speaker 7 of 8
Julie G. Burel, La Jolla Institute, USA
Short Talk: Transcriptomic Profiling of Memory CD4 T Cells Reveals Novel Immune Signatures of Latent Tuberculosis

Wednesday, January 18 | 8:30AM - 11:45AM
T Cell Memory: A Prerequisite to Vaccine Efficacy
Room: British/Columbia Ballroom

Speaker 8 of 8
Patricia A. Darrah, NIAID, National Institutes of Health, USA
Short Talk: Aerosol or Intravenous BCG Immunization Induces Robust Tissue Resident T Cell Immunity in the Lungs of Nonhuman Primates

Wednesday, January 18 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Wednesday, January 18 | 5:00PM - 6:45PM
Bugs and Drugs: New Biological Insights Relating to Therapy
Room: British/Columbia Ballroom

Speaker 1 of 4
* Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA

Wednesday, January 18 | 5:00PM - 6:45PM
Bugs and Drugs: New Biological Insights Relating to Therapy
Room: British/Columbia Ballroom

Speaker 2 of 4
Veronique Anne Dartois, Hackensack Meridian Health, USA
The Impact of Lesion Diversity on Therapy

Wednesday, January 18 | 5:00PM - 6:45PM
Bugs and Drugs: New Biological Insights Relating to Therapy
Room: British/Columbia Ballroom

Speaker 3 of 4
Valerie Mizrahi, University of Cape Town, South Africa
Metabolic Vulnerabilities in M. tuberculosis: Lessons from Guanine Nucleotide Metabolism

Wednesday, January 18 | 5:00PM - 6:45PM
Bugs and Drugs: New Biological Insights Relating to Therapy
Room: British/Columbia Ballroom

Speaker 4 of 4
Dirk Schnappinger, Weill Cornell Medical College, USA
Genetic Analyses of Essential M. tuberculosis Genes

Wednesday, January 18 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: British/Columbia Ballroom


Wednesday, January 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, January 18 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Wednesday, January 18 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Thursday, January 19 | 10:25AM - 10:25AM
Departure


*Session Chair.