Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Phosphoinositide Biology: New Therapeutic Targets Beyond Class I PI3K (2018B5)

Web Desc
PI3K Pathways in Immunology, Growth Disorders and Cancer Organizer(s): Leon O. Murphy, Klaus Okkenhaug and Sabina C. Cosulich Date: January 19 - 23, 2017 Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA Sponsored by Bayer HealthCare Pharmaceuticals, Cell Signaling Technology, Inc., Incyte Corporation and Pfizer Inc. Summary of Meeting: The overall goal for this meeting is to bring together scientific leaders and trainees with a common interest in PI3Ks and relevant downstream physiological processes. It will address advances in basic molecular and cellular mechanisms that are regulated by PI3Ks, other PI kinases and, their cognate phosphatases; highlight new advances in the characterization of PI3K pathway alterations in genetic syndromes that affect growth and the immune and nervous systems; and provide an important update on the clinical development of PI3K pathway inhibitors, and implications for the burgeoning field of cancer immunotherapy. Whole exome sequencing studies have increasingly implicated PI3K signaling in diseases (immune, growth and neurological disorders) which may benefit from drugs currently in development for cancer and inflammation. This meeting will be an important forum for discussing approaches to treating these additional disorders. Scholarship Deadline: September 21 2016 Discounted Abstract Deadline: September 21 2016 Abstract Deadline: October 19 2016 Discounted Registration Deadline: November 16 2016 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: AstraZeneca Cell Signaling Technology, Inc. Genentech, Inc. Novartis Institutes for BioMedical Research Third Rock Ventures We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

PI3K Pathways in Immunology, Growth Disorders and Cancer

Organizer(s): Leon O. Murphy, Klaus Okkenhaug and Sabina C. Cosulich

Date: January 19 - 23, 2017
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA

Sponsored by Bayer HealthCare Pharmaceuticals, Cell Signaling Technology, Inc., Incyte Corporation and Pfizer Inc.

Summary of Meeting:

The overall goal for this meeting is to bring together scientific leaders and trainees with a common interest in PI3Ks and relevant downstream physiological processes. It will address advances in basic molecular and cellular mechanisms that are regulated by PI3Ks, other PI kinases and, their cognate phosphatases; highlight new advances in the characterization of PI3K pathway alterations in genetic syndromes that affect growth and the immune and nervous systems; and provide an important update on the clinical development of PI3K pathway inhibitors, and implications for the burgeoning field of cancer immunotherapy. Whole exome sequencing studies have increasingly implicated PI3K signaling in diseases (immune, growth and neurological disorders) which may benefit from drugs currently in development for cancer and inflammation. This meeting will be an important forum for discussing approaches to treating these additional disorders.

Scholarship Deadline: September 21 2016

Discounted Abstract Deadline: September 21 2016

Abstract Deadline: October 19 2016

Discounted Registration Deadline: November 16 2016

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

AstraZeneca

Cell Signaling Technology, Inc.

Genentech, Inc.

Novartis Institutes for BioMedical Research

Third Rock Ventures

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Thursday, January 19 \| 4:00PM - 8:00PM Arrival and Registration Room: Promenade
Thursday, January 19 \| 6:00PM - 8:00PM Welcome Mixer Room: Promenade No registration fees are used to fund alcohol served at this function.
Friday, January 20 \| 7:00AM - 8:00AM Breakfast Room: Pecos/Canyon
Friday, January 20 \| 8:00AM - 11:15AM PI3K Function and Physiology Room: Mesa A-B Speaker 9 of 9 Kyle A. Edgar, Genentech, Inc., USA Short Talk: The PI3K Inhibitor, Taselisib, has Enhanced Potency in PIK3CA Mutant Models Through a Unique Mechanism of Action
Friday, January 20 \| 8:00AM - 11:15AM PI3K Function and Physiology Room: Mesa A-B Speaker 8 of 9 John E. Burke, University of Victoria, Canada Short Talk: Conformational Disturbance of PI3Kdelta Regulation by Primary Immunodeficiency Mutations in PIK3CD and PIK3R1
Friday, January 20 \| 8:00AM - 11:15AM PI3K Function and Physiology Room: Mesa A-B Speaker 7 of 9 Jeffery L. Kutok, Epizyme, Inc., USA The PI3K-gamma Inhibitor, IPI-549, Increases Antitumor Immunity by Targeting Tumor-Associated Myeloid Cells and Overcomes Immune Checkpoint Blockade Resistance in Preclinical Tumor Models
Friday, January 20 \| 8:00AM - 11:15AM PI3K Function and Physiology Room: Mesa A-B Speaker 6 of 9 Matthias P. Wymann, University of Basel, Switzerland Complexity in PI3K Signaling and Targeting
Friday, January 20 \| 8:00AM - 11:15AM PI3K Function and Physiology Room: Mesa A-B Coffee Break
Friday, January 20 \| 8:00AM - 11:15AM PI3K Function and Physiology Room: Mesa A-B Speaker 4 of 9 Bart Vanhaesebroeck, University College London, Cancer Institute, UK Physiological Roles of PI3K Isoforms
Friday, January 20 \| 8:00AM - 11:15AM PI3K Function and Physiology Room: Mesa A-B Speaker 3 of 9 Len R. Stephens, Babraham Institute, UK Signaling via Class I PI3Ks
Friday, January 20 \| 8:00AM - 11:15AM PI3K Function and Physiology Room: Mesa A-B Speaker 2 of 9 * Doreen A. Cantrell, University of Dundee, UK
Friday, January 20 \| 8:00AM - 11:15AM PI3K Function and Physiology Room: Mesa A-B Speaker 1 of 9 * Lewis C. Cantley, Weill Cornell Medicine, USA
Friday, January 20 \| 11:15AM - 1:00PM Poster Setup Room: Mesa C
Friday, January 20 \| 11:15AM - 5:00PM On Own for Lunch
Friday, January 20 \| 1:00PM - 10:00PM Poster Viewing Room: Mesa C
Friday, January 20 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Friday, January 20 \| 5:00PM - 7:00PM PI3K Effectors Room: Mesa A-B Speaker 6 of 6 Ivan Yudushkin, Medical University of Vienna, Austria Short Talk: Membrane Subpopulations of mTORC2 Display Distinct Sensitivity to PI3K
Friday, January 20 \| 5:00PM - 7:00PM PI3K Effectors Room: Mesa A-B Speaker 5 of 6 John Blenis, Weill Cornell Medical College, USA mTORC1/S6K1: Regulation of RNA Biogenesis, Protein Synthesis and Cell Metabolism
Friday, January 20 \| 5:00PM - 7:00PM PI3K Effectors Room: Mesa A-B Speaker 4 of 6 David A. Fruman, University of California, Irvine, USA The mTORC1/4E-BP/eIF4E Axis in B-Cell Activation and Transformation
Friday, January 20 \| 5:00PM - 7:00PM PI3K Effectors Room: Mesa A-B Speaker 3 of 6 Brendan D. Manning, Harvard School of Public Health, USA The TSC-Rheb-mTOR Circuit and Metabolic Control
Friday, January 20 \| 5:00PM - 7:00PM PI3K Effectors Room: Mesa A-B Speaker 2 of 6 * Igor Vivanco, Institute of Cancer Research, UK
Friday, January 20 \| 5:00PM - 7:00PM PI3K Effectors Room: Mesa A-B Speaker 1 of 6 * Sabina C. Cosulich, AstraZeneca Oncology, UK
Friday, January 20 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Pecos/Canyon No registration fees are used to fund alcohol served at this function.
Friday, January 20 \| 7:30PM - 10:00PM Poster Session 1 Room: Mesa C
Saturday, January 21 \| 7:00AM - 8:00AM Breakfast Room: Pecos/Canyon
Saturday, January 21 \| 8:00AM - 11:15AM Phosphatases Room: Mesa A-B Speaker 1 of 9 * Brendan D. Manning, Harvard School of Public Health, USA
Saturday, January 21 \| 8:00AM - 11:15AM Phosphatases Room: Mesa A-B Speaker 2 of 9 * Len R. Stephens, Babraham Institute, UK
Saturday, January 21 \| 8:00AM - 11:15AM Phosphatases Room: Mesa A-B Speaker 3 of 9 Ramon Parsons, Icahn School of Medicine at Mount Sinai, USA PTEN Upstream, Instream and Downstream
Saturday, January 21 \| 8:00AM - 11:15AM Phosphatases Room: Mesa A-B Speaker 4 of 9 Lloyd Trotman, Cold Spring Harbor Laboratory, USA PTEN Function and Loss of Function in Prostate Metastasis
Saturday, January 21 \| 8:00AM - 11:15AM Phosphatases Room: Mesa A-B Coffee Break
Saturday, January 21 \| 8:00AM - 11:15AM Phosphatases Room: Mesa A-B Speaker 6 of 9 Christina Anne Mitchell, Monash University, Australia New Roles for Inositol Polyphosphate Phosphatases
Saturday, January 21 \| 8:00AM - 11:15AM Phosphatases Room: Mesa A-B Speaker 7 of 9 Doreen A. Cantrell, University of Dundee, UK Phosphatidylinositol-3-Kinase Control of T Lymphocyte Differentiation: Dogma Versus Reality
Saturday, January 21 \| 8:00AM - 11:15AM Phosphatases Room: Mesa A-B Speaker 8 of 9 Ana Clara Carrera, Centro Nacional Biotechnologia/CSIC, Spain Short Talk: PI3K Depletion Induces Tumor Regression; E-Cadherin Downregulation Sensitizes PTEN-Mutant Tumors to PI3K-Beta Silencing
Saturday, January 21 \| 8:00AM - 11:15AM Phosphatases Room: Mesa A-B Speaker 9 of 9 Sarah E. Conduit, University College London, UK Short Talk: INPP5E Regulates Murine SHH Medulloblastoma
Saturday, January 21 \| 11:15AM - 2:30PM On Own for Lunch
Saturday, January 21 \| 11:15AM - 1:00PM Poster Setup Room: Mesa C
Saturday, January 21 \| 1:00PM - 10:00PM Poster Viewing Room: Mesa C
Saturday, January 21 \| 2:30PM - 4:30PM Workshop 1: PI3K, Metabolism and Stress Pathways Room: Mesa A-B Speaker 1 of 8 * Kyle A. Edgar, Genentech, Inc., USA
Saturday, January 21 \| 2:30PM - 4:30PM Workshop 1: PI3K, Metabolism and Stress Pathways Room: Mesa A-B Speaker 2 of 8 * John E. Burke, University of Victoria, Canada
Saturday, January 21 \| 2:30PM - 4:30PM Workshop 1: PI3K, Metabolism and Stress Pathways Room: Mesa A-B Speaker 3 of 8 Jack Flanagan, University of Auckland, New Zealand Evidence of a New Mechanism for Achieving PI3K Inhibition with Small Molecules via an Effect on Membrane Binding
Saturday, January 21 \| 2:30PM - 4:30PM Workshop 1: PI3K, Metabolism and Stress Pathways Room: Mesa A-B Speaker 4 of 8 Thomas Leonard, Max F. Perutz Laboratories GmbH, Austria PI(3,4,5)P3 Allosterically Activates Akt
Saturday, January 21 \| 2:30PM - 4:30PM Workshop 1: PI3K, Metabolism and Stress Pathways Room: Mesa A-B Speaker 5 of 8 Erika Ilagan, Harvard T.H. Chan School of Public Health, USA The TSC-Rheb-mTORC1 Circuit is a Shared Effector of PI3K-Akt and Ras-Erk Signaling
Saturday, January 21 \| 2:30PM - 4:30PM Workshop 1: PI3K, Metabolism and Stress Pathways Room: Mesa A-B Speaker 6 of 8 Gina Lee, Weill Cornell Medicine, USA mTORC1-S6K1 Regulation of SR Protein Kinase Links mRNA Biogenesis to De Novo Lipid Synthesis
Saturday, January 21 \| 2:30PM - 4:30PM Workshop 1: PI3K, Metabolism and Stress Pathways Room: Mesa A-B Speaker 7 of 8 Marie H. Solheim, Joslin Diabetes Center, Harvard Medical School, USA Conserved p85alpha SH2 Domain Residues Play Differential Roles in p85alpha-IRS-1 Binding
Saturday, January 21 \| 2:30PM - 4:30PM Workshop 1: PI3K, Metabolism and Stress Pathways Room: Mesa A-B Speaker 8 of 8 Lukasz Pawel Magiera, University of Cambridge, UK Pik3ca Gain-of-Function Mutation Restricted to Mesenchymal Cells Expressing Fibroblast Activation Protein-Alpha Causes Skeletal Overgrowth
Saturday, January 21 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Saturday, January 21 \| 5:00PM - 7:00PM Class II/III PI3Ks Room: Mesa A-B Speaker 1 of 5 * Jonathan M. Backer, Albert Einstein College of Medicine, USA
Saturday, January 21 \| 5:00PM - 7:00PM Class II/III PI3Ks Room: Mesa A-B Speaker 2 of 5 Volker Haucke, Leibniz Forschungsinstitut für Molekulare Pharmakologie, Germany Phosphoinositide Conversion in the Endolysosomal System
Saturday, January 21 \| 5:00PM - 7:00PM Class II/III PI3Ks Room: Mesa A-B Speaker 3 of 5 Leon O. Murphy, Casma Therapeutics, USA Role of VPS34 in Cancer Growth and Autophagy
Saturday, January 21 \| 5:00PM - 7:00PM Class II/III PI3Ks Room: Mesa A-B Speaker 4 of 5 Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy Class II PI3K in Mitosis
Saturday, January 21 \| 5:00PM - 7:00PM Class II/III PI3Ks Room: Mesa A-B Speaker 5 of 5 Wei-Xing Zong, Rutgers University, USA Short Talk: PI3-Kinase p110beta Regulates Cell Metabolism and Oncogenesis by Promoting Endocytic Turnover of Nutrient Transporters
Saturday, January 21 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Pecos/Canyon No registration fees are used to fund alcohol served at this function.
Saturday, January 21 \| 7:30PM - 10:00PM Poster Session 2 Room: Mesa C
Sunday, January 22 \| 7:00AM - 8:00AM Breakfast Room: Pecos/Canyon
Sunday, January 22 \| 8:00AM - 11:15AM Signaling from Non-Canonical PI Kinases Room: Mesa A-B Speaker 1 of 9 * Bart Vanhaesebroeck, University College London, Cancer Institute, UK
Sunday, January 22 \| 8:00AM - 11:15AM Signaling from Non-Canonical PI Kinases Room: Mesa A-B Speaker 2 of 9 * Klaus Okkenhaug, University of Cambridge, UK
Sunday, January 22 \| 8:00AM - 11:15AM Signaling from Non-Canonical PI Kinases Room: Mesa A-B Speaker 3 of 9 Brooke M. Emerling, Sanford Burnham Prebys Medical Discovery Institute, USA PI5P4Ks and Cancer Metabolism
Sunday, January 22 \| 8:00AM - 11:15AM Signaling from Non-Canonical PI Kinases Room: Mesa A-B Speaker 4 of 9 Pietro V. De Camilli, Yale University School of Medicine, USA Phosphoinositide Dynamics at the Plasma Membrane
Sunday, January 22 \| 8:00AM - 11:15AM Signaling from Non-Canonical PI Kinases Room: Mesa A-B Coffee Break
Sunday, January 22 \| 8:00AM - 11:15AM Signaling from Non-Canonical PI Kinases Room: Mesa A-B Speaker 6 of 9 Nullin Divecha, University of Southampton, UK Phosphoinositides and Nuclear Signaling
Sunday, January 22 \| 8:00AM - 11:15AM Signaling from Non-Canonical PI Kinases Room: Mesa A-B Speaker 7 of 9 Tamas Balla, NICHD, National Institutes of Health, USA Phosphatidylinositol 4-Kinases: Keys to Lipid Transport and Metabolism
Sunday, January 22 \| 8:00AM - 11:15AM Signaling from Non-Canonical PI Kinases Room: Mesa A-B Speaker 8 of 9 Miguel Murillo, Institute of Cancer Research, UK Short Talk: Disrupting RAS-PI3K Interaction Promotes EFGR-Induced Tumor Regression Abrogating RAC1-Mediated Positive Feedback Loop
Sunday, January 22 \| 8:00AM - 11:15AM Signaling from Non-Canonical PI Kinases Room: Mesa A-B Speaker 9 of 9 Sreenivasa R. Chinni, Wayne State University, USA Short Talk: PI4KIII Alpha-CXCR4 Axis Cross-Talk in Prostate Cancer Promotes Cell Invasion
Sunday, January 22 \| 11:15AM - 5:00PM On Own for Lunch
Sunday, January 22 \| 11:15AM - 1:00PM Poster Setup Room: Mesa C
Sunday, January 22 \| 1:00PM - 10:00PM Poster Viewing Room: Mesa C
Sunday, January 22 \| 3:00PM - 4:30PM Panel: Career Development Room: Mesa A-B This panel will include an established PI, a new PI, an industry scientist and will facilitate an interactive session on early career development for scientists. Speaker 1 of 5 * Leon O. Murphy, Casma Therapeutics, USA
Sunday, January 22 \| 3:00PM - 4:30PM Panel: Career Development Room: Mesa A-B This panel will include an established PI, a new PI, an industry scientist and will facilitate an interactive session on early career development for scientists. Speaker 2 of 5 Brooke M. Emerling, Sanford Burnham Prebys Medical Discovery Institute, USA
Sunday, January 22 \| 3:00PM - 4:30PM Panel: Career Development Room: Mesa A-B This panel will include an established PI, a new PI, an industry scientist and will facilitate an interactive session on early career development for scientists. Speaker 3 of 5 Igor Vivanco, Institute of Cancer Research, UK
Sunday, January 22 \| 3:00PM - 4:30PM Panel: Career Development Room: Mesa A-B This panel will include an established PI, a new PI, an industry scientist and will facilitate an interactive session on early career development for scientists. Speaker 4 of 5 Suchithra Menon, Novartis, USA
Sunday, January 22 \| 3:00PM - 4:30PM Panel: Career Development Room: Mesa A-B This panel will include an established PI, a new PI, an industry scientist and will facilitate an interactive session on early career development for scientists. Speaker 5 of 5 Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA
Sunday, January 22 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Sunday, January 22 \| 5:00PM - 7:00PM Overgrowth Syndromes Room: Mesa A-B Speaker 1 of 6 * Edith M. Hessel, GlaxoSmithKline, UK
Sunday, January 22 \| 5:00PM - 7:00PM Overgrowth Syndromes Room: Mesa A-B Speaker 2 of 6 * Leon O. Murphy, Casma Therapeutics, USA
Sunday, January 22 \| 5:00PM - 7:00PM Overgrowth Syndromes Room: Mesa A-B Speaker 3 of 6 Robert K. Semple, University of Edinburgh, UK Human Disorders of Growth due to Type 1A PI3K Mutations
Sunday, January 22 \| 5:00PM - 7:00PM Overgrowth Syndromes Room: Mesa A-B Speaker 4 of 6 Kathleen Millen, Seattle Children's Research Institute, USA The Role of PIK3CA in Megalencephaly and Epilepsy
Sunday, January 22 \| 5:00PM - 7:00PM Overgrowth Syndromes Room: Mesa A-B Speaker 5 of 6 Cameron C. Trenor III, Boston Children's Hospital, USA Overgrowth and Vascular Anomalies: PIK3CA Heterogeneity and Sirolimus Responses
Sunday, January 22 \| 5:00PM - 7:00PM Overgrowth Syndromes Room: Mesa A-B Speaker 6 of 6 Ghayda Mirzaa, Seattle Children's Hospital, USA Short Talk: Mosaic and Constitutional Mutations of the PI3K-AKT-MTOR Pathway are Associated with a Wide Spectrum of Developmental Brain Disorders from Focal Cortical Dysplasia to Diffuse Megalencephaly with Autism
Sunday, January 22 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Pecos/Canyon No registration fees are used to fund alcohol served at this function.
Sunday, January 22 \| 7:30PM - 10:00PM Poster Session 3 Room: Mesa C
Monday, January 23 \| 7:00AM - 8:00AM Breakfast Room: Pecos/Canyon
Monday, January 23 \| 8:00AM - 11:15AM PI3K in Immunity and Infection Room: Mesa A-B Speaker 1 of 8 * David A. Fruman, University of California, Irvine, USA
Monday, January 23 \| 8:00AM - 11:15AM PI3K in Immunity and Infection Room: Mesa A-B Speaker 2 of 8 Klaus Okkenhaug, University of Cambridge, UK Class I PI3K Isoforms and Mutants in Immunity, Infection and Cancer
Monday, January 23 \| 8:00AM - 11:15AM PI3K in Immunity and Infection Room: Mesa A-B Speaker 3 of 8 Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA PIK3CD and Immunodeficiency
Monday, January 23 \| 8:00AM - 11:15AM PI3K in Immunity and Infection Room: Mesa A-B Coffee Break
Monday, January 23 \| 8:00AM - 11:15AM PI3K in Immunity and Infection Room: Mesa A-B Speaker 5 of 8 Laurence A. Turka, Rheos Medicines, USA PI3K Signaling and Metabolism in Regulatory T Cells
Monday, January 23 \| 8:00AM - 11:15AM PI3K in Immunity and Infection Room: Mesa A-B Speaker 6 of 8 Edith M. Hessel, GlaxoSmithKline, UK Developing PI3K Inhibitors for COPD and Respiratory Disease
Monday, January 23 \| 8:00AM - 11:15AM PI3K in Immunity and Infection Room: Mesa A-B Speaker 7 of 8 Christoph Burkhart, Novartis Institutes for BioMedical Research, Switzerland Short Talk: The PI3K-Delta Inhibitor CDZ173 (leniolisib) Rescues the Immune Cell Defects and Improves the Clinical Course in Patients with Activated PI3K-delta Syndrome (APDS)
Monday, January 23 \| 8:00AM - 11:15AM PI3K in Immunity and Infection Room: Mesa A-B Speaker 8 of 8 Carrie L. Lucas, Yale University, USA Short Talk: Human Immune Dysregulation Caused by Mutations in the Gene Encoding the p110g PI3K Subunit
Monday, January 23 \| 11:15AM - 2:30PM On Own for Lunch
Monday, January 23 \| 2:30PM - 4:30PM Workshop 2: PI3K in Immune Disorders and Immuno-Oncology Room: Mesa A-B Speaker 1 of 9 * Carrie L. Lucas, Yale University, USA
Monday, January 23 \| 2:30PM - 4:30PM Workshop 2: PI3K in Immune Disorders and Immuno-Oncology Room: Mesa A-B Speaker 2 of 9 * Christoph Burkhart, Novartis Institutes for BioMedical Research, Switzerland
Monday, January 23 \| 2:30PM - 4:30PM Workshop 2: PI3K in Immune Disorders and Immuno-Oncology Room: Mesa A-B Speaker 3 of 9 Honyin Chiu, University of California, Irvine, USA A Novel Role for the 4E-BP/eIF4E Axis in B Cell Antibody Class Switching
Monday, January 23 \| 2:30PM - 4:30PM Workshop 2: PI3K in Immune Disorders and Immuno-Oncology Room: Mesa A-B Speaker 4 of 9 Elissa K. Deenick, Garvan Institute of Medical Research, Australia Over Activation of PI3K Causes Defects In B-Cell Development and Differentiation
Monday, January 23 \| 2:30PM - 4:30PM Workshop 2: PI3K in Immune Disorders and Immuno-Oncology Room: Mesa A-B Speaker 5 of 9 Anne-Katrien Stark, Babraham Institute, UK PI3Kdelta Hyper-Activation Results in Increased Susceptibility to S. Pneumoniae Airway Infection
Monday, January 23 \| 2:30PM - 4:30PM Workshop 2: PI3K in Immune Disorders and Immuno-Oncology Room: Mesa A-B Speaker 6 of 9 Maria Gonzalez-Nunez, Queen Mary University of London, UK The Role of p110delta PI3K Signaling in NOD2-Mediated Gastrointestinal Immunity and Inflammation
Monday, January 23 \| 2:30PM - 4:30PM Workshop 2: PI3K in Immune Disorders and Immuno-Oncology Room: Mesa A-B Speaker 7 of 9 Aimé Cézaire Adiko, Center for Research on Inflammation/ Paris University, France Opposite Effects of two PI3K Gamma Regulatory Subunits in Dendritic Cells
Monday, January 23 \| 2:30PM - 4:30PM Workshop 2: PI3K in Immune Disorders and Immuno-Oncology Room: Mesa A-B Speaker 8 of 9 Anita Chandra, Babraham Institute, UK B Cell Function and Development in the Context of PI3Kdelta Hyper-Activation
Monday, January 23 \| 2:30PM - 4:30PM Workshop 2: PI3K in Immune Disorders and Immuno-Oncology Room: Mesa A-B Speaker 9 of 9 Sarah H. Ross, Babraham Institute, UK Understanding the Regulation of PI(3,4,5)P3 Levels in Effector Cytotoxic T Lymphocytes
Monday, January 23 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Monday, January 23 \| 5:00PM - 6:30PM PI3K and Oncology Room: Mesa A-B Speaker 1 of 4 * John Blenis, Weill Cornell Medical College, USA
Monday, January 23 \| 5:00PM - 6:30PM PI3K and Oncology Room: Mesa A-B Speaker 2 of 4 Mika Derynck, Genentech, Inc., USA Clinical Drug Development of PI3K Pathway Inhibitors in Solid Tumors: Threading the Needle for a Therapeutic Index
Monday, January 23 \| 5:00PM - 6:30PM PI3K and Oncology Room: Mesa A-B Speaker 3 of 4 Sabina C. Cosulich, AstraZeneca Oncology, UK Clinical Development of mTOR Inhibitors
Monday, January 23 \| 5:00PM - 6:30PM PI3K and Oncology Room: Mesa A-B Speaker 4 of 4 Jennifer R. Brown, Dana-Farber Cancer Institute, USA Clinical Development of PI3K Inhibitors for CLL
Monday, January 23 \| 6:30PM - 7:15PM Closing Keynote Address Room: Mesa A-B Speaker 1 of 2 * Leon O. Murphy, Casma Therapeutics, USA
Monday, January 23 \| 6:30PM - 7:15PM Closing Keynote Address Room: Mesa A-B Speaker 2 of 2 Lewis C. Cantley, Weill Cornell Medicine, USA PI3K and Cancer Metabolism
Monday, January 23 \| 7:15PM - 7:30PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Mesa A-B
Monday, January 23 \| 8:15PM - 9:15PM Social Hour with Lite Bites Room: Promenade/Mesa Ballroom No registration fees are used to fund alcohol served at this function.
Monday, January 23 \| 8:15PM - 11:00PM Entertainment Room: Mesa Ballroom Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Monday, January 23 \| 9:15PM - 11:00PM Cash Bar Room: Mesa Ballroom
Tuesday, January 24 \| 10:25AM - 10:25AM Departure *Session Chair.