Web Desc
PI3K Pathways in Immunology, Growth Disorders and Cancer
Organizer(s): Leon O. Murphy, Klaus Okkenhaug and Sabina C. Cosulich
Date: January 19 - 23, 2017
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Sponsored by Bayer HealthCare Pharmaceuticals, Cell Signaling Technology, Inc., Incyte Corporation and Pfizer Inc.
Summary of Meeting:
The overall goal for this meeting is to bring together scientific leaders and trainees with a common interest in PI3Ks and relevant downstream physiological processes. It will address advances in basic molecular and cellular mechanisms that are regulated by PI3Ks, other PI kinases and, their cognate phosphatases; highlight new advances in the characterization of PI3K pathway alterations in genetic syndromes that affect growth and the immune and nervous systems; and provide an important update on the clinical development of PI3K pathway inhibitors, and implications for the burgeoning field of cancer immunotherapy. Whole exome sequencing studies have increasingly implicated PI3K signaling in diseases (immune, growth and neurological disorders) which may benefit from drugs currently in development for cancer and inflammation. This meeting will be an important forum for discussing approaches to treating these additional disorders.
Scholarship Deadline: September 21 2016
Discounted Abstract Deadline: September 21 2016
Abstract Deadline: October 19 2016
Discounted Registration Deadline: November 16 2016
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer HealthCare PharmaceuticalsCell Signaling Technology, Inc.Incyte CorporationPfizer Inc.
We gratefully acknowledge additional support for this conference from:
Bethyl Laboratories, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

AstraZeneca

Cell Signaling Technology, Inc.

Genentech, Inc.

Novartis Institutes for BioMedical Research

Third Rock Ventures
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, January 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Promenade


Thursday, January 19 | 6:00PM - 8:00PM
Welcome Mixer
Room: Promenade
No registration fees are used to fund alcohol served at this function.

Friday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Pecos/Canyon


Friday, January 20 | 8:00AM - 11:15AM
PI3K Function and Physiology
Room: Mesa A-B

Speaker 9 of 9
Kyle A. Edgar, Genentech, Inc., USA
Short Talk: The PI3K Inhibitor, Taselisib, has Enhanced Potency in PIK3CA Mutant Models Through a Unique Mechanism of Action

Friday, January 20 | 8:00AM - 11:15AM
PI3K Function and Physiology
Room: Mesa A-B

Speaker 8 of 9
John E. Burke, University of Victoria, Canada
Short Talk: Conformational Disturbance of PI3Kdelta Regulation by Primary Immunodeficiency Mutations in PIK3CD and PIK3R1

Friday, January 20 | 8:00AM - 11:15AM
PI3K Function and Physiology
Room: Mesa A-B

Speaker 7 of 9
Jeffery L. Kutok, Epizyme, Inc., USA
The PI3K-gamma Inhibitor, IPI-549, Increases Antitumor Immunity by Targeting Tumor-Associated Myeloid Cells and Overcomes Immune Checkpoint Blockade Resistance in Preclinical Tumor Models

Friday, January 20 | 8:00AM - 11:15AM
PI3K Function and Physiology
Room: Mesa A-B

Speaker 6 of 9
Matthias P. Wymann, University of Basel, Switzerland
Complexity in PI3K Signaling and Targeting


Friday, January 20 | 8:00AM - 11:15AM
PI3K Function and Physiology
Room: Mesa A-B


Coffee Break

Friday, January 20 | 8:00AM - 11:15AM
PI3K Function and Physiology
Room: Mesa A-B

Speaker 4 of 9
Bart Vanhaesebroeck, University College London, Cancer Institute, UK
Physiological Roles of PI3K Isoforms

Friday, January 20 | 8:00AM - 11:15AM
PI3K Function and Physiology
Room: Mesa A-B

Speaker 3 of 9
Len R. Stephens, Babraham Institute, UK
Signaling via Class I PI3Ks

Friday, January 20 | 8:00AM - 11:15AM
PI3K Function and Physiology
Room: Mesa A-B

Speaker 2 of 9
* Doreen A. Cantrell, University of Dundee, UK

Friday, January 20 | 8:00AM - 11:15AM
PI3K Function and Physiology
Room: Mesa A-B

Speaker 1 of 9
* Lewis C. Cantley, Weill Cornell Medicine, USA

Friday, January 20 | 11:15AM - 1:00PM
Poster Setup
Room: Mesa C


Friday, January 20 | 11:15AM - 5:00PM
On Own for Lunch


Friday, January 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Friday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Friday, January 20 | 5:00PM - 7:00PM
PI3K Effectors
Room: Mesa A-B

Speaker 6 of 6
Ivan Yudushkin, Medical University of Vienna, Austria
Short Talk: Membrane Subpopulations of mTORC2 Display Distinct Sensitivity to PI3K

Friday, January 20 | 5:00PM - 7:00PM
PI3K Effectors
Room: Mesa A-B

Speaker 5 of 6
John Blenis, Weill Cornell Medical College, USA
mTORC1/S6K1: Regulation of RNA Biogenesis, Protein Synthesis and Cell Metabolism

Friday, January 20 | 5:00PM - 7:00PM
PI3K Effectors
Room: Mesa A-B

Speaker 4 of 6
David A. Fruman, University of California, Irvine, USA
The mTORC1/4E-BP/eIF4E Axis in B-Cell Activation and Transformation

Friday, January 20 | 5:00PM - 7:00PM
PI3K Effectors
Room: Mesa A-B

Speaker 3 of 6
Brendan D. Manning, Harvard School of Public Health, USA
The TSC-Rheb-mTOR Circuit and Metabolic Control

Friday, January 20 | 5:00PM - 7:00PM
PI3K Effectors
Room: Mesa A-B

Speaker 2 of 6
* Igor Vivanco, Institute of Cancer Research, UK

Friday, January 20 | 5:00PM - 7:00PM
PI3K Effectors
Room: Mesa A-B

Speaker 1 of 6
* Sabina C. Cosulich, AstraZeneca Oncology, UK

Friday, January 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pecos/Canyon
No registration fees are used to fund alcohol served at this function.

Friday, January 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Mesa C


Saturday, January 21 | 7:00AM - 8:00AM
Breakfast
Room: Pecos/Canyon


Saturday, January 21 | 8:00AM - 11:15AM
Phosphatases
Room: Mesa A-B

Speaker 1 of 9
* Brendan D. Manning, Harvard School of Public Health, USA

Saturday, January 21 | 8:00AM - 11:15AM
Phosphatases
Room: Mesa A-B

Speaker 2 of 9
* Len R. Stephens, Babraham Institute, UK

Saturday, January 21 | 8:00AM - 11:15AM
Phosphatases
Room: Mesa A-B

Speaker 3 of 9
Ramon Parsons, Icahn School of Medicine at Mount Sinai, USA
PTEN Upstream, Instream and Downstream

Saturday, January 21 | 8:00AM - 11:15AM
Phosphatases
Room: Mesa A-B

Speaker 4 of 9
Lloyd Trotman, Cold Spring Harbor Laboratory, USA
PTEN Function and Loss of Function in Prostate Metastasis

Saturday, January 21 | 8:00AM - 11:15AM
Phosphatases
Room: Mesa A-B


Coffee Break

Saturday, January 21 | 8:00AM - 11:15AM
Phosphatases
Room: Mesa A-B

Speaker 6 of 9
Christina Anne Mitchell, Monash University, Australia
New Roles for Inositol Polyphosphate Phosphatases

Saturday, January 21 | 8:00AM - 11:15AM
Phosphatases
Room: Mesa A-B

Speaker 7 of 9
Doreen A. Cantrell, University of Dundee, UK
Phosphatidylinositol-3-Kinase Control of T Lymphocyte Differentiation: Dogma Versus Reality

Saturday, January 21 | 8:00AM - 11:15AM
Phosphatases
Room: Mesa A-B

Speaker 8 of 9
Ana Clara Carrera, Centro Nacional Biotechnologia/CSIC, Spain
Short Talk: PI3K Depletion Induces Tumor Regression; E-Cadherin Downregulation Sensitizes PTEN-Mutant Tumors to PI3K-Beta Silencing

Saturday, January 21 | 8:00AM - 11:15AM
Phosphatases
Room: Mesa A-B

Speaker 9 of 9
Sarah E. Conduit, University College London, UK
Short Talk: INPP5E Regulates Murine SHH Medulloblastoma

Saturday, January 21 | 11:15AM - 2:30PM
On Own for Lunch


Saturday, January 21 | 11:15AM - 1:00PM
Poster Setup
Room: Mesa C


Saturday, January 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Saturday, January 21 | 2:30PM - 4:30PM
Workshop 1: PI3K, Metabolism and Stress Pathways
Room: Mesa A-B

Speaker 1 of 8
* Kyle A. Edgar, Genentech, Inc., USA

Saturday, January 21 | 2:30PM - 4:30PM
Workshop 1: PI3K, Metabolism and Stress Pathways
Room: Mesa A-B

Speaker 2 of 8
* John E. Burke, University of Victoria, Canada

Saturday, January 21 | 2:30PM - 4:30PM
Workshop 1: PI3K, Metabolism and Stress Pathways
Room: Mesa A-B

Speaker 3 of 8
Jack Flanagan, University of Auckland, New Zealand
Evidence of a New Mechanism for Achieving PI3K Inhibition with Small Molecules via an Effect on Membrane Binding

Saturday, January 21 | 2:30PM - 4:30PM
Workshop 1: PI3K, Metabolism and Stress Pathways
Room: Mesa A-B

Speaker 4 of 8
Thomas Leonard, Max F. Perutz Laboratories GmbH, Austria
PI(3,4,5)P3 Allosterically Activates Akt

Saturday, January 21 | 2:30PM - 4:30PM
Workshop 1: PI3K, Metabolism and Stress Pathways
Room: Mesa A-B

Speaker 5 of 8
Erika Ilagan, Harvard T.H. Chan School of Public Health, USA
The TSC-Rheb-mTORC1 Circuit is a Shared Effector of PI3K-Akt and Ras-Erk Signaling

Saturday, January 21 | 2:30PM - 4:30PM
Workshop 1: PI3K, Metabolism and Stress Pathways
Room: Mesa A-B

Speaker 6 of 8
Gina Lee, Weill Cornell Medicine, USA
mTORC1-S6K1 Regulation of SR Protein Kinase Links mRNA Biogenesis to De Novo Lipid Synthesis

Saturday, January 21 | 2:30PM - 4:30PM
Workshop 1: PI3K, Metabolism and Stress Pathways
Room: Mesa A-B

Speaker 7 of 8
Marie H. Solheim, Joslin Diabetes Center, Harvard Medical School, USA
Conserved p85alpha SH2 Domain Residues Play Differential Roles in p85alpha-IRS-1 Binding

Saturday, January 21 | 2:30PM - 4:30PM
Workshop 1: PI3K, Metabolism and Stress Pathways
Room: Mesa A-B

Speaker 8 of 8
Lukasz Pawel Magiera, University of Cambridge, UK
Pik3ca Gain-of-Function Mutation Restricted to Mesenchymal Cells Expressing Fibroblast Activation Protein-Alpha Causes Skeletal Overgrowth

Saturday, January 21 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Saturday, January 21 | 5:00PM - 7:00PM
Class II/III PI3Ks
Room: Mesa A-B

Speaker 1 of 5
* Jonathan M. Backer, Albert Einstein College of Medicine, USA

Saturday, January 21 | 5:00PM - 7:00PM
Class II/III PI3Ks
Room: Mesa A-B

Speaker 2 of 5
Volker Haucke, Leibniz Forschungsinstitut für Molekulare Pharmakologie, Germany
Phosphoinositide Conversion in the Endolysosomal System

Saturday, January 21 | 5:00PM - 7:00PM
Class II/III PI3Ks
Room: Mesa A-B

Speaker 3 of 5
Leon O. Murphy, Casma Therapeutics, USA
Role of VPS34 in Cancer Growth and Autophagy

Saturday, January 21 | 5:00PM - 7:00PM
Class II/III PI3Ks
Room: Mesa A-B

Speaker 4 of 5
Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy
Class II PI3K in Mitosis

Saturday, January 21 | 5:00PM - 7:00PM
Class II/III PI3Ks
Room: Mesa A-B

Speaker 5 of 5
Wei-Xing Zong, Rutgers University, USA
Short Talk: PI3-Kinase p110beta Regulates Cell Metabolism and Oncogenesis by Promoting Endocytic Turnover of Nutrient Transporters

Saturday, January 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pecos/Canyon
No registration fees are used to fund alcohol served at this function.

Saturday, January 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Mesa C


Sunday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Pecos/Canyon


Sunday, January 22 | 8:00AM - 11:15AM
Signaling from Non-Canonical PI Kinases
Room: Mesa A-B

Speaker 1 of 9
* Bart Vanhaesebroeck, University College London, Cancer Institute, UK

Sunday, January 22 | 8:00AM - 11:15AM
Signaling from Non-Canonical PI Kinases
Room: Mesa A-B

Speaker 2 of 9
* Klaus Okkenhaug, University of Cambridge, UK

Sunday, January 22 | 8:00AM - 11:15AM
Signaling from Non-Canonical PI Kinases
Room: Mesa A-B

Speaker 3 of 9
Brooke M. Emerling, Sanford Burnham Prebys Medical Discovery Institute, USA
PI5P4Ks and Cancer Metabolism

Sunday, January 22 | 8:00AM - 11:15AM
Signaling from Non-Canonical PI Kinases
Room: Mesa A-B

Speaker 4 of 9
Pietro V. De Camilli, Yale University School of Medicine, USA
Phosphoinositide Dynamics at the Plasma Membrane

Sunday, January 22 | 8:00AM - 11:15AM
Signaling from Non-Canonical PI Kinases
Room: Mesa A-B


Coffee Break

Sunday, January 22 | 8:00AM - 11:15AM
Signaling from Non-Canonical PI Kinases
Room: Mesa A-B

Speaker 6 of 9
Nullin Divecha, University of Southampton, UK
Phosphoinositides and Nuclear Signaling

Sunday, January 22 | 8:00AM - 11:15AM
Signaling from Non-Canonical PI Kinases
Room: Mesa A-B

Speaker 7 of 9
Tamas Balla, NICHD, National Institutes of Health, USA
Phosphatidylinositol 4-Kinases: Keys to Lipid Transport and Metabolism

Sunday, January 22 | 8:00AM - 11:15AM
Signaling from Non-Canonical PI Kinases
Room: Mesa A-B

Speaker 8 of 9
Miguel Murillo, Institute of Cancer Research, UK
Short Talk: Disrupting RAS-PI3K Interaction Promotes EFGR-Induced Tumor Regression Abrogating RAC1-Mediated Positive Feedback Loop

Sunday, January 22 | 8:00AM - 11:15AM
Signaling from Non-Canonical PI Kinases
Room: Mesa A-B

Speaker 9 of 9
Sreenivasa R. Chinni, Wayne State University, USA
Short Talk: PI4KIII Alpha-CXCR4 Axis Cross-Talk in Prostate Cancer Promotes Cell Invasion

Sunday, January 22 | 11:15AM - 5:00PM
On Own for Lunch


Sunday, January 22 | 11:15AM - 1:00PM
Poster Setup
Room: Mesa C


Sunday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Sunday, January 22 | 3:00PM - 4:30PM
Panel: Career Development
Room: Mesa A-B
This panel will include an established PI, a new PI, an industry scientist and will facilitate an interactive session on early career development for scientists.
Speaker 1 of 5
* Leon O. Murphy, Casma Therapeutics, USA

Sunday, January 22 | 3:00PM - 4:30PM
Panel: Career Development
Room: Mesa A-B
This panel will include an established PI, a new PI, an industry scientist and will facilitate an interactive session on early career development for scientists.
Speaker 2 of 5
Brooke M. Emerling, Sanford Burnham Prebys Medical Discovery Institute, USA

Sunday, January 22 | 3:00PM - 4:30PM
Panel: Career Development
Room: Mesa A-B
This panel will include an established PI, a new PI, an industry scientist and will facilitate an interactive session on early career development for scientists.
Speaker 3 of 5
Igor Vivanco, Institute of Cancer Research, UK

Sunday, January 22 | 3:00PM - 4:30PM
Panel: Career Development
Room: Mesa A-B
This panel will include an established PI, a new PI, an industry scientist and will facilitate an interactive session on early career development for scientists.
Speaker 4 of 5
Suchithra Menon, Novartis, USA

Sunday, January 22 | 3:00PM - 4:30PM
Panel: Career Development
Room: Mesa A-B
This panel will include an established PI, a new PI, an industry scientist and will facilitate an interactive session on early career development for scientists.
Speaker 5 of 5
Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA

Sunday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Sunday, January 22 | 5:00PM - 7:00PM
Overgrowth Syndromes
Room: Mesa A-B

Speaker 1 of 6
* Edith M. Hessel, GlaxoSmithKline, UK

Sunday, January 22 | 5:00PM - 7:00PM
Overgrowth Syndromes
Room: Mesa A-B

Speaker 2 of 6
* Leon O. Murphy, Casma Therapeutics, USA

Sunday, January 22 | 5:00PM - 7:00PM
Overgrowth Syndromes
Room: Mesa A-B

Speaker 3 of 6
Robert K. Semple, University of Edinburgh, UK
Human Disorders of Growth due to Type 1A PI3K Mutations

Sunday, January 22 | 5:00PM - 7:00PM
Overgrowth Syndromes
Room: Mesa A-B

Speaker 4 of 6
Kathleen Millen, Seattle Children's Research Institute, USA
The Role of PIK3CA in Megalencephaly and Epilepsy

Sunday, January 22 | 5:00PM - 7:00PM
Overgrowth Syndromes
Room: Mesa A-B

Speaker 5 of 6
Cameron C. Trenor III, Boston Children's Hospital, USA
Overgrowth and Vascular Anomalies: PIK3CA Heterogeneity and Sirolimus Responses

Sunday, January 22 | 5:00PM - 7:00PM
Overgrowth Syndromes
Room: Mesa A-B

Speaker 6 of 6
Ghayda Mirzaa, Seattle Children's Hospital, USA
Short Talk: Mosaic and Constitutional Mutations of the PI3K-AKT-MTOR Pathway are Associated with a Wide Spectrum of Developmental Brain Disorders from Focal Cortical Dysplasia to Diffuse Megalencephaly with Autism

Sunday, January 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pecos/Canyon
No registration fees are used to fund alcohol served at this function.

Sunday, January 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Mesa C


Monday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Pecos/Canyon


Monday, January 23 | 8:00AM - 11:15AM
PI3K in Immunity and Infection
Room: Mesa A-B

Speaker 1 of 8
* David A. Fruman, University of California, Irvine, USA

Monday, January 23 | 8:00AM - 11:15AM
PI3K in Immunity and Infection
Room: Mesa A-B

Speaker 2 of 8
Klaus Okkenhaug, University of Cambridge, UK
Class I PI3K Isoforms and Mutants in Immunity, Infection and Cancer

Monday, January 23 | 8:00AM - 11:15AM
PI3K in Immunity and Infection
Room: Mesa A-B

Speaker 3 of 8
Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA
PIK3CD and Immunodeficiency

Monday, January 23 | 8:00AM - 11:15AM
PI3K in Immunity and Infection
Room: Mesa A-B


Coffee Break

Monday, January 23 | 8:00AM - 11:15AM
PI3K in Immunity and Infection
Room: Mesa A-B

Speaker 5 of 8
Laurence A. Turka, Rheos Medicines, USA
PI3K Signaling and Metabolism in Regulatory T Cells

Monday, January 23 | 8:00AM - 11:15AM
PI3K in Immunity and Infection
Room: Mesa A-B

Speaker 6 of 8
Edith M. Hessel, GlaxoSmithKline, UK
Developing PI3K Inhibitors for COPD and Respiratory Disease

Monday, January 23 | 8:00AM - 11:15AM
PI3K in Immunity and Infection
Room: Mesa A-B

Speaker 7 of 8
Christoph Burkhart, Novartis Institutes for BioMedical Research, Switzerland
Short Talk: The PI3K-Delta Inhibitor CDZ173 (leniolisib) Rescues the Immune Cell Defects and Improves the Clinical Course in Patients with Activated PI3K-delta Syndrome (APDS)

Monday, January 23 | 8:00AM - 11:15AM
PI3K in Immunity and Infection
Room: Mesa A-B

Speaker 8 of 8
Carrie L. Lucas, Yale University, USA
Short Talk: Human Immune Dysregulation Caused by Mutations in the Gene Encoding the p110g PI3K Subunit

Monday, January 23 | 11:15AM - 2:30PM
On Own for Lunch


Monday, January 23 | 2:30PM - 4:30PM
Workshop 2: PI3K in Immune Disorders and Immuno-Oncology
Room: Mesa A-B

Speaker 1 of 9
* Carrie L. Lucas, Yale University, USA

Monday, January 23 | 2:30PM - 4:30PM
Workshop 2: PI3K in Immune Disorders and Immuno-Oncology
Room: Mesa A-B

Speaker 2 of 9
* Christoph Burkhart, Novartis Institutes for BioMedical Research, Switzerland

Monday, January 23 | 2:30PM - 4:30PM
Workshop 2: PI3K in Immune Disorders and Immuno-Oncology
Room: Mesa A-B

Speaker 3 of 9
Honyin Chiu, University of California, Irvine, USA
A Novel Role for the 4E-BP/eIF4E Axis in B Cell Antibody Class Switching

Monday, January 23 | 2:30PM - 4:30PM
Workshop 2: PI3K in Immune Disorders and Immuno-Oncology
Room: Mesa A-B

Speaker 4 of 9
Elissa K. Deenick, Garvan Institute of Medical Research, Australia
Over Activation of PI3K Causes Defects In B-Cell Development and Differentiation

Monday, January 23 | 2:30PM - 4:30PM
Workshop 2: PI3K in Immune Disorders and Immuno-Oncology
Room: Mesa A-B

Speaker 5 of 9
Anne-Katrien Stark, Babraham Institute, UK
PI3Kdelta Hyper-Activation Results in Increased Susceptibility to S. Pneumoniae Airway Infection

Monday, January 23 | 2:30PM - 4:30PM
Workshop 2: PI3K in Immune Disorders and Immuno-Oncology
Room: Mesa A-B

Speaker 6 of 9
Maria Gonzalez-Nunez, Queen Mary University of London, UK
The Role of p110delta PI3K Signaling in NOD2-Mediated Gastrointestinal Immunity and Inflammation

Monday, January 23 | 2:30PM - 4:30PM
Workshop 2: PI3K in Immune Disorders and Immuno-Oncology
Room: Mesa A-B

Speaker 7 of 9
Aimé Cézaire Adiko, Center for Research on Inflammation/ Paris University, France
Opposite Effects of two PI3K Gamma Regulatory Subunits in Dendritic Cells

Monday, January 23 | 2:30PM - 4:30PM
Workshop 2: PI3K in Immune Disorders and Immuno-Oncology
Room: Mesa A-B

Speaker 8 of 9
Anita Chandra, Babraham Institute, UK
B Cell Function and Development in the Context of PI3Kdelta Hyper-Activation

Monday, January 23 | 2:30PM - 4:30PM
Workshop 2: PI3K in Immune Disorders and Immuno-Oncology
Room: Mesa A-B

Speaker 9 of 9
Sarah H. Ross, Babraham Institute, UK
Understanding the Regulation of PI(3,4,5)P3 Levels in Effector Cytotoxic T Lymphocytes

Monday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, January 23 | 5:00PM - 6:30PM
PI3K and Oncology
Room: Mesa A-B

Speaker 1 of 4
* John Blenis, Weill Cornell Medical College, USA

Monday, January 23 | 5:00PM - 6:30PM
PI3K and Oncology
Room: Mesa A-B

Speaker 2 of 4
Mika Derynck, Genentech, Inc., USA
Clinical Drug Development of PI3K Pathway Inhibitors in Solid Tumors: Threading the Needle for a Therapeutic Index

Monday, January 23 | 5:00PM - 6:30PM
PI3K and Oncology
Room: Mesa A-B

Speaker 3 of 4
Sabina C. Cosulich, AstraZeneca Oncology, UK
Clinical Development of mTOR Inhibitors

Monday, January 23 | 5:00PM - 6:30PM
PI3K and Oncology
Room: Mesa A-B

Speaker 4 of 4
Jennifer R. Brown, Dana-Farber Cancer Institute, USA
Clinical Development of PI3K Inhibitors for CLL

Monday, January 23 | 6:30PM - 7:15PM
Closing Keynote Address
Room: Mesa A-B

Speaker 1 of 2
* Leon O. Murphy, Casma Therapeutics, USA

Monday, January 23 | 6:30PM - 7:15PM
Closing Keynote Address
Room: Mesa A-B

Speaker 2 of 2
Lewis C. Cantley, Weill Cornell Medicine, USA
PI3K and Cancer Metabolism

Monday, January 23 | 7:15PM - 7:30PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Mesa A-B


Monday, January 23 | 8:15PM - 9:15PM
Social Hour with Lite Bites
Room: Promenade/Mesa Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, January 23 | 8:15PM - 11:00PM
Entertainment
Room: Mesa Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Monday, January 23 | 9:15PM - 11:00PM
Cash Bar
Room: Mesa Ballroom


Tuesday, January 24 | 10:25AM - 10:25AM
Departure


*Session Chair.