Web Desc
Biobetters and Next-Generation Biologics: Innovative Strategies for Optimally Effective Therapies
Organizer(s): Cherié L. Butts, Amy S. Rosenberg, Amy D. Klion and Sachdev S. Sidhu
Date: January 22 - 26, 2017
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by Genmab A/S, ImmunoGen, Inc., Merck & Co., Inc., Mersana Therapeutics, Pfizer Inc. and Roche
Summary of Meeting:
The purpose of this meeting is to examine different approaches for treatment of cancer and other diseases (e.g., fibrosis, autoimmunity and inflammatory diseases). The program will provide insights from academic and industry scientists on innovative biologics technologies and treatment strategies for ameliorating disease in an effort to identify synergies and opportunities to cross-fertilize approaches. Furthermore, the meeting includes perspectives from the US Food & Drug Administration and how the outlined strategies will impact the drug review and approval process. The intention is to better inform meeting attendees of current/future strategies for treating disease and best practices for transforming concepts into approved drugs.
Scholarship Deadline: September 21 2016
Discounted Abstract Deadline: September 21 2016
Abstract Deadline: October 20 2016
Discounted Registration Deadline: November 21 2016
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Genmab A/SImmunoGen, Inc.Merck & Co., Inc.Mersana TherapeuticsPfizer Inc.Roche
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Amgen Inc.

ArmaGen

Biogen

Codiak Biosciences

EpiVax, Inc.

Regeneron Pharmaceuticals, Inc.

Thermo Fisher Scientific Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI126942-01
Funding for this conference was made possible (in part) by 1R13AI126942-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 22 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Sunday, January 22 | 6:00PM - 8:00PM
Welcome Mixer
Room: Ballroom Lobby
No registration fees are used to fund alcohol served at this function.

Monday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, January 23 | 8:00AM - 9:00AM
Welcome by the Organizers and Keynote Address
Room: Ballroom 2-3

Speaker 1 of 2
* Amy S. Rosenberg, U.S. Food and Drug Administration, USA

Monday, January 23 | 8:00AM - 9:00AM
Welcome by the Organizers and Keynote Address
Room: Ballroom 2-3

Speaker 2 of 2
Arne Skerra, Technical University of Munich, Germany
Advanced Protein Design Concepts for Biopharmaceutical Drug Discovery and Development: Anticalins and PASylation

Monday, January 23 | 9:00AM - 11:15AM
Modified and Alternative Scaffolds as Novel Biotherapeutics
Room: Ballroom 2-3

Speaker 1 of 7
* Andreas G. Plückthun, University of Zürich, Switzerland

Monday, January 23 | 9:00AM - 11:15AM
Modified and Alternative Scaffolds as Novel Biotherapeutics
Room: Ballroom 2-3

Speaker 2 of 7
Karl Dane Wittrup, Massachusetts Institute of Technology, USA
Engineering Synergistic Innate and Adaptive Cancer Immunotherapy

Monday, January 23 | 9:00AM - 11:15AM
Modified and Alternative Scaffolds as Novel Biotherapeutics
Room: Ballroom 2-3


Coffee Break

Monday, January 23 | 9:00AM - 11:15AM
Modified and Alternative Scaffolds as Novel Biotherapeutics
Room: Ballroom 2-3

Speaker 4 of 7
Shohei Koide, New York University Langone Health, USA
Controlling Cell Signaling with Designer Binding Proteins

Monday, January 23 | 9:00AM - 11:15AM
Modified and Alternative Scaffolds as Novel Biotherapeutics
Room: Ballroom 2-3

Speaker 5 of 7
Ken G. Andersson, Royal Institute of Technology, Sweden
Short Talk: Development and Optimization of an E. coli-Based Display Platform for Selection of Affinity Proteins

Monday, January 23 | 9:00AM - 11:15AM
Modified and Alternative Scaffolds as Novel Biotherapeutics
Room: Ballroom 2-3

Speaker 6 of 7
Takamitsu Hattori, New York University School of Medicine, USA
Short Talk: Antigen Clasping Enables Exceptional Specificity toward Peptides Harboring Post-Translational Modifications

Monday, January 23 | 9:00AM - 11:15AM
Modified and Alternative Scaffolds as Novel Biotherapeutics
Room: Ballroom 2-3

Speaker 7 of 7
Nina G. Caculitan, Genentech, Inc., USA
Short Talk: The Processing of Antibody Drug Conjugates by Proteases

Monday, January 23 | 11:15AM - 5:00PM
On Own for Lunch


Monday, January 23 | 11:15AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Monday, January 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Monday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, January 23 | 5:00PM - 7:00PM
Non-Antibody Scaffolds, Microenvironment Modulators
Room: Ballroom 2-3

Speaker 1 of 5
* Amy D. Klion, NIAID, National Institutes of Health, USA

Monday, January 23 | 5:00PM - 7:00PM
Non-Antibody Scaffolds, Microenvironment Modulators
Room: Ballroom 2-3

Speaker 2 of 5
James W. Lillard, Jr., Morehouse School of Medicine, USA
Novel Protein Antagonists Targeting Chemokine Receptors Involved in Cancer and Inflammatory Diseases

Monday, January 23 | 5:00PM - 7:00PM
Non-Antibody Scaffolds, Microenvironment Modulators
Room: Ballroom 2-3

Speaker 3 of 5
John C. Bell, Ottawa Hospital Research Institute, Canada
Virotherapies

Monday, January 23 | 5:00PM - 7:00PM
Non-Antibody Scaffolds, Microenvironment Modulators
Room: Ballroom 2-3

Speaker 4 of 5
Margaret Karow, Akrevia Therapeutics, USA
Optimizing Biologics for Therapeutic Use

Monday, January 23 | 5:00PM - 7:00PM
Non-Antibody Scaffolds, Microenvironment Modulators
Room: Ballroom 2-3

Speaker 5 of 5
Arron Hearn, Abzena plc, UK
Short Talk: A Deimmunised form of the Ribotoxin, Alpha-Sarcin, Lacking CD4+ T Cell Epitopes and its use as an Immunotoxin Warhead

Monday, January 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Monday, January 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Wasatch


Tuesday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles
To encourage networking, particularly among early-career scientists, organizers will be available at reserved tables to discuss specific topics.


Table 1 - Careers in Industry: At and Away from the Bench (Cherié L. Butts)

Tuesday, January 24 | 8:00AM - 11:30AM
Enhancing Activity and Tissue-Specific Targeting/Strategies
for PK Optimization

Room: Ballroom 2-3

Speaker 1 of 8
* Amy S. Rosenberg, U.S. Food and Drug Administration, USA

Tuesday, January 24 | 8:00AM - 11:30AM
Enhancing Activity and Tissue-Specific Targeting/Strategies
for PK Optimization

Room: Ballroom 2-3

Speaker 2 of 8
Anne S. De Groot, EpiVax, Inc., USA
Novel Methods for Addressing Immunogenicity in Therapeutic Proteins

Tuesday, January 24 | 8:00AM - 11:30AM
Enhancing Activity and Tissue-Specific Targeting/Strategies
for PK Optimization

Room: Ballroom 2-3

Speaker 3 of 8
Nancy M. Dahms, Medical College of Wisconsin, USA
Targeting Muscle Cells

Tuesday, January 24 | 8:00AM - 11:30AM
Enhancing Activity and Tissue-Specific Targeting/Strategies
for PK Optimization

Room: Ballroom 2-3

Speaker 4 of 8
Ashley M. Buckle, Monash University, Australia
Short Talk: Circumventing the Stability-Function Trade-Off in Protein Engineering

Tuesday, January 24 | 8:00AM - 11:30AM
Enhancing Activity and Tissue-Specific Targeting/Strategies
for PK Optimization

Room: Ballroom 2-3


Coffee Break

Tuesday, January 24 | 8:00AM - 11:30AM
Enhancing Activity and Tissue-Specific Targeting/Strategies
for PK Optimization

Room: Ballroom 2-3

Speaker 6 of 8
Lynn E. Macdonald, Regeneron Pharmaceuticals, USA
Engineered Mice to Study Novel Antibody and Antibody-Like Molecules

Tuesday, January 24 | 8:00AM - 11:30AM
Enhancing Activity and Tissue-Specific Targeting/Strategies
for PK Optimization

Room: Ballroom 2-3

Speaker 7 of 8
Ruben Boado, ArmaGen, USA
Treatment of Human Lysosomal Storage Disorders with Blood-Brain Barrier Penetrating IgG-fusion Proteins

Tuesday, January 24 | 8:00AM - 11:30AM
Enhancing Activity and Tissue-Specific Targeting/Strategies
for PK Optimization

Room: Ballroom 2-3

Speaker 8 of 8
Andrew D. Baik, Regeneron Pharmaceuticals, USA
Short Talk: Engineering Tissue Specific Delivery of Enzymes for Lysosomal Storage Disease Treatment

Tuesday, January 24 | 11:30AM - 5:00PM
On Own for Lunch


Tuesday, January 24 | 11:30AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Tuesday, January 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Tuesday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, January 24 | 5:00PM - 7:00PM
Bispecific and Antibody-Drug Conjugates
Room: Ballroom 2-3

Speaker 1 of 5
* Cherié L. Butts, Biogen Inc, USA

Tuesday, January 24 | 5:00PM - 7:00PM
Bispecific and Antibody-Drug Conjugates
Room: Ballroom 2-3

Speaker 2 of 5
Jennifer R. Cochran, Stanford University, USA
Designer Multispecific Proteins Based on Natural Ligands


Tuesday, January 24 | 5:00PM - 7:00PM
Bispecific and Antibody-Drug Conjugates
Room: Ballroom 2-3

Speaker 3 of 5
Ariel Munitz, Tel Aviv University, Israel
Targeting ITIM-Bearing Receptors in Mucosal Inflammation


Tuesday, January 24 | 5:00PM - 7:00PM
Bispecific and Antibody-Drug Conjugates
Room: Ballroom 2-3

Speaker 4 of 5
Kisu Kim, Mogam Institute for Biomedical Research, South Korea
Short Talk: Whole IgG Like Bispecific Antibodies Engaging T Cells for Cancer Immunotherapy

Tuesday, January 24 | 5:00PM - 7:00PM
Bispecific and Antibody-Drug Conjugates
Room: Ballroom 2-3

Speaker 5 of 5
Stefan R. Schmidt, Rentschler Biotechnology, Germany
Short Talk: Manufacturing of Complex Biobetters: Half-Life Extended Fusion Proteins and Bispecific Molecules

Tuesday, January 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Tuesday, January 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby/Wasatch


Wednesday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles
To encourage networking, particularly among early-career scientists, organizers will be available at reserved tables to discuss specific topics.


Table 1 - Clinical Trial Design: Getting it Right (Amy D. Klion)


Table 2 - Paradigm Shift: Scientist and Entrepreneur (Cherié L. Butts)

Wednesday, January 25 | 8:00AM - 11:00AM
Different Approaches to Targeting Tumors: Melanoma as an Exa
mple

Room: Ballroom 2-3

Speaker 1 of 7
* James W. Lillard, Jr., Morehouse School of Medicine, USA

Wednesday, January 25 | 8:00AM - 11:00AM
Different Approaches to Targeting Tumors: Melanoma as an Exa
mple

Room: Ballroom 2-3

Speaker 2 of 7
Amy S. Rosenberg, U.S. Food and Drug Administration, USA
Mechanisms for Accelerated Approval, Breakthrough Therapies

Wednesday, January 25 | 8:00AM - 11:00AM
Different Approaches to Targeting Tumors: Melanoma as an Exa
mple

Room: Ballroom 2-3

Speaker 3 of 7
Luca Gattinoni, NCI, National Institutes of Health, USA
Harnessing T Memory Stem Cells for Adoptive Cell Transfer Therapy of Cancer

Wednesday, January 25 | 8:00AM - 11:00AM
Different Approaches to Targeting Tumors: Melanoma as an Exa
mple

Room: Ballroom 2-3


Coffee Break

Wednesday, January 25 | 8:00AM - 11:00AM
Different Approaches to Targeting Tumors: Melanoma as an Exa
mple

Room: Ballroom 2-3

Speaker 5 of 7
Pierre Bruhns, Institut Pasteur, France
Microdroplet-Based Massive Kinetic Analyses Reveal Secretion Rate and Affinity from Individual Antibody-Secreting Cells

Wednesday, January 25 | 8:00AM - 11:00AM
Different Approaches to Targeting Tumors: Melanoma as an Exa
mple

Room: Ballroom 2-3

Speaker 6 of 7
Réjean Lapointe, University of Montreal, CHUM, Canada
Increasing Complexity in Combining Cancer Immunotherapies

Wednesday, January 25 | 8:00AM - 11:00AM
Different Approaches to Targeting Tumors: Melanoma as an Exa
mple

Room: Ballroom 2-3

Speaker 7 of 7
James Torchia, Massachusetts General Hospital, USA
Short Talk: Targeting Lymphoma with Precision using Semisynthetic Anti-Idiotype Peptibodies

Wednesday, January 25 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 25 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Wednesday, January 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Wednesday, January 25 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, January 25 | 5:00PM - 7:15PM
Biologics in Autoimmunity/Autoinflammatory Disorders
Room: Ballroom 2-3

Speaker 1 of 6
* Amy D. Klion, NIAID, National Institutes of Health, USA

Wednesday, January 25 | 5:00PM - 7:15PM
Biologics in Autoimmunity/Autoinflammatory Disorders
Room: Ballroom 2-3

Speaker 2 of 6
Virginia Pascual, Cornell University, USA
SLE

Wednesday, January 25 | 5:00PM - 7:15PM
Biologics in Autoimmunity/Autoinflammatory Disorders
Room: Ballroom 2-3

Speaker 3 of 6
Raphaela Theresia Goldbach-Mansky, NIAID, National Institutes of Health, USA
IL-1-Mediated Autoinflammatory Disorders

Wednesday, January 25 | 5:00PM - 7:15PM
Biologics in Autoimmunity/Autoinflammatory Disorders
Room: Ballroom 2-3

Speaker 4 of 6
Andreas G. Plückthun, University of Zürich, Switzerland
Next-Generation Biologics: Exploiting the Opportunities for Protein Engineering

Wednesday, January 25 | 5:00PM - 7:15PM
Biologics in Autoimmunity/Autoinflammatory Disorders
Room: Ballroom 2-3

Speaker 5 of 6
David P. Humphreys, UCB Pharma, UK
Short Talk: Statistical Design for Effector Function Engineering of Hexameric Fc Domains as a Recombinant IVIG Alternative

Wednesday, January 25 | 5:00PM - 7:15PM
Biologics in Autoimmunity/Autoinflammatory Disorders
Room: Ballroom 2-3

Speaker 6 of 6
Takashi K. Kishimoto, Selecta Biosciences, USA
Short Talk: Developing Biobetters with Improved Efficacy and Safety by Addressing Product Immunogenicity with Tolerogenic Nanoparticles

Wednesday, January 25 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch
No registration fees are used to fund alcohol served at this function.

Wednesday, January 25 | 7:30PM - 10:00PM
Poster Session 3
Room: Superior/Superior Lobby/Wasatch


Thursday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles
To encourage networking, particularly among early-career scientists, organizers will be available at reserved tables to discuss specific topics.


Table 1 - Careers in Government: At and Away from the Bench (Amy S. Rosenberg)


Table 2 - Academia vs. Government vs. Industry (Cherié L. Butts)

Thursday, January 26 | 8:00AM - 11:00AM
Multimodal Approaches to Allergic Inflammation
Room: Ballroom 2-3

Speaker 1 of 7
* Réjean Lapointe, University of Montreal, CHUM, Canada

Thursday, January 26 | 8:00AM - 11:00AM
Multimodal Approaches to Allergic Inflammation
Room: Ballroom 2-3

Speaker 2 of 7
Amy D. Klion, NIAID, National Institutes of Health, USA
Eosinophil-Targeted Therapy: Lessons Learned from the Treatment of Hypereosinophilic Syndromes

Thursday, January 26 | 8:00AM - 11:00AM
Multimodal Approaches to Allergic Inflammation
Room: Ballroom 2-3

Speaker 3 of 7
Bruce S. Bochner, Northwestern University Feinberg School of Medicine, USA
Targeting Siglecs in Allergic Inflammatory Disease

Thursday, January 26 | 8:00AM - 11:00AM
Multimodal Approaches to Allergic Inflammation
Room: Ballroom 2-3


Coffee Break

Thursday, January 26 | 8:00AM - 11:00AM
Multimodal Approaches to Allergic Inflammation
Room: Ballroom 2-3

Speaker 5 of 7
Hector G. Ortega, GlaxoSmithKline, USA
Blocking Eosinophilic Inflammation with Biologics: Current Experience

Thursday, January 26 | 8:00AM - 11:00AM
Multimodal Approaches to Allergic Inflammation
Room: Ballroom 2-3

Speaker 6 of 7
Mark P. Waterhouse, University of Leeds, UK
Short Talk: Novel Specific Agents for Blocking IgG-FcgammaRIIIa Interactions

Thursday, January 26 | 8:00AM - 11:00AM
Multimodal Approaches to Allergic Inflammation
Room: Ballroom 2-3

Speaker 7 of 7
Katharine D. Grugan, Janssen R&D, USA
Short Talk: The Role of Multiple Fc Gamma Receptors in an Antibody Dependent Cellular Phagocytosis Potency Assay

Thursday, January 26 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, January 26 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, January 26 | 5:00PM - 6:30PM
Concept to Clinic to Market
Room: Ballroom 3

Speaker 1 of 4
* Margaret Karow, Akrevia Therapeutics, USA

Thursday, January 26 | 5:00PM - 6:30PM
Concept to Clinic to Market
Room: Ballroom 3

Speaker 2 of 4
Cherié L. Butts, Biogen Inc, USA
Strategies for Transforming Ideas into Viable Drug Candidates

Thursday, January 26 | 5:00PM - 6:30PM
Concept to Clinic to Market
Room: Ballroom 3

Speaker 3 of 4
Stylianos Bournazos, Rockefeller University, USA
Optimization of Anti-HIV Antibodies for Prevention and Therapy

Thursday, January 26 | 5:00PM - 6:30PM
Concept to Clinic to Market
Room: Ballroom 3

Speaker 4 of 4
Teresa S. Wiley, Wiley Systems, Inc, USA
Short Talk: Steroid Hormone Exposure on Regulation of P53 and Bcl-2: Bio-Mimetic Hormone Replacement Therapy and the Quality of Life for Breast Cancer Patients

Thursday, January 26 | 6:30PM - 7:15PM
Closing Keynote Address
Room: Ballroom 3

Speaker 1 of 2
* Cherié L. Butts, Biogen Inc, USA

Thursday, January 26 | 6:30PM - 7:15PM
Closing Keynote Address
Room: Ballroom 3

Speaker 2 of 2
Douglas E. Williams, Codiak Biosciences, USA
Exosomes and Extracellular Vesicles: One Man’s Trash Is Another Man’s Treasure

Thursday, January 26 | 7:15PM - 7:30PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Ballroom 3


Thursday, January 26 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Ballroom 1-2
No registration fees are used to fund alcohol served at this function.

Thursday, January 26 | 8:30PM - 11:00PM
Entertainment
Room: Ballroom 1-2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 26 | 8:30PM - 11:00PM
Cash Bar
Room: Ballroom 1-2


Friday, January 27 | 10:25AM - 10:25AM
Departure


*Session Chair.