Web Desc
Epigenetics and Human Disease: Progress from Mechanisms to Therapeutics
Organizer(s): Johnathan R. Whetstine, Jessica K. Tyler and Rab K. Prinjha
Date: January 29 - February 02, 2017
Location: Sheraton Seattle Hotel, Seattle, WA, USA
Sponsored by Incyte Corporation, Merck & Co., Inc., Taylor & Francis and Vertex Pharmaceuticals Incorporated
Summary of Meeting:
Epigenetics impacts human health and disease. Data from a range of diseases (cancer, neurological and immunological disorders) have documented mutations, altered expression and copy number alterations in numerous epigenetic factors (histones, DNA and chromatin modifying enzymes, reader proteins, chromatin modulators and noncoding RNAs). Genome-wide data has also illustrated the relationship between altered epigenetic states (e.g., modified DNA and histones) and disease onset and progression. Therefore, there is a need to discover the molecular mechanisms and interplay between epigenetic regulators. These mechanistic insights will shed light on the impact epigenetic regulators have on cellular homeostasis, while resolving their pathogenic contribution to disease states. This meeting is aimed at interrogating the most current knowledge surrounding the epigenetic events modulating nuclear function (gene expression regulation, enhancer modulation, domains and structural organization as well as cell division and differentiation), while relating this to developmental and disease models. In addition, this meeting will highlight the impact that preclinical and clinical epigenetic therapeutics have on a panel of diseases including cancer and neurological disorders. By presenting these various aspects associated with epigenetics and diverse disease, this unique forum should promote dynamic discussions, interactions and collaborations that will impact our understanding of disease and possible treatment strategies. Opportunities for trainee career development, networking and oral presentations are provided by a “Focus on Junior Scientists” session, a panel discussion and mixer with scientific editors and another with industry scientists.
Scholarship Deadline: September 29 2016
Discounted Abstract Deadline: September 29 2016
Abstract Deadline: October 27 2016
Discounted Registration Deadline: November 30 2016
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Incyte CorporationMerck & Co., Inc.Taylor & FrancisVertex Pharmaceuticals Incorporated
We gratefully acknowledge additional support for this conference from:
March of Dimes Foundation, Grant No. 4-FY16-317
Porvair Sciences Ltd & Chromatrap
Zymo Research Corporation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Epizyme, Inc.

GlaxoSmithKline UK
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 29 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Ballroom Foyer


Sunday, January 29 | 6:00PM - 8:00PM
Welcome Mixer
Room: Grand Ballroom Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 30 | 7:30AM - 8:30AM
Breakfast
Room: Grand Ballroom AB


Monday, January 30 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Grand Ballroom CD

Speaker 1 of 4
* Jessica K. Tyler, Weill Cornell Medicine, USA

Monday, January 30 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Grand Ballroom CD

Speaker 2 of 4
* Johnathan R. Whetstine, Fox Chase Cancer Center, USA

Monday, January 30 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Grand Ballroom CD

Speaker 3 of 4
* Rab K. Prinjha, GlaxoSmithKline, UK

Monday, January 30 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Grand Ballroom CD

Speaker 4 of 4
Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Epigenetics, Stem Cells and Disease Research

Monday, January 30 | 9:30AM - 11:45AM
Epigenetics and Genome Organization
Room: Grand Ballroom CD

Speaker 1 of 7
* Bradley E. Bernstein, Massachusetts General Hospital, USA

Monday, January 30 | 9:30AM - 11:45AM
Epigenetics and Genome Organization
Room: Grand Ballroom CD

Speaker 2 of 7
Thomas Misteli, NCI, National Institutes of Health, USA
Deep Imaging of the Genome

Monday, January 30 | 9:30AM - 11:45AM
Epigenetics and Genome Organization
Room: Grand Ballroom CD


Coffee Break

Monday, January 30 | 9:30AM - 11:45AM
Epigenetics and Genome Organization
Room: Grand Ballroom CD

Speaker 4 of 7
Bas van Steensel, Netherlands Cancer Institute, Netherlands
Architecture, Dynamics and Function of Genome - Nuclear Lamina Interactions

Monday, January 30 | 9:30AM - 11:45AM
Epigenetics and Genome Organization
Room: Grand Ballroom CD

Speaker 5 of 7
Kadir Akdemir, University of Texas MD Anderson Cancer Center, USA
Short Talk: Spatial Organization of the Genome & Structural Alterations in Human Cancers

Monday, January 30 | 9:30AM - 11:45AM
Epigenetics and Genome Organization
Room: Grand Ballroom CD

Speaker 6 of 7
Robert Hansel-Hertsch, University of Cambridge, UK
Short Talk: G-Quadruplex Structures Mark Human Regulatory Chromatin

Monday, January 30 | 9:30AM - 11:45AM
Epigenetics and Genome Organization
Room: Grand Ballroom CD

Speaker 7 of 7
Janneke Peeters, University Medical Center Utrecht, Netherlands
Short Talk: Enhancers in Autoimmune Disease Cells Contribute to Disease Pathogenesis and Can be Targeted to Reduce Autoimmunity

Monday, January 30 | 11:45AM - 5:00PM
On Own for Lunch


Monday, January 30 | 11:45AM - 1:00PM
Poster Setup
Room: Grand Ballroom AB


Monday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Ballroom AB


Monday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Ballroom Foyer


Monday, January 30 | 5:00PM - 7:00PM
From Epigenomics to Disease
Room: Grand Ballroom CD

Speaker 1 of 5
* Henk G. Stunnenberg, Radboud University, Netherlands

Monday, January 30 | 5:00PM - 7:00PM
From Epigenomics to Disease
Room: Grand Ballroom CD

Speaker 2 of 5
Bradley E. Bernstein, Massachusetts General Hospital, USA
Epigenetic Mechanisms of Tumor Initiation and Evolution

Monday, January 30 | 5:00PM - 7:00PM
From Epigenomics to Disease
Room: Grand Ballroom CD

Speaker 3 of 5
Joseph F. Costello, University of California, San Francisco, USA
Losing Driver Mutations, Gaining Insight into Epigenome Evolution

Monday, January 30 | 5:00PM - 7:00PM
From Epigenomics to Disease
Room: Grand Ballroom CD

Speaker 4 of 5
John A. Stamatoyannopoulos, Altius Institute for Biomedical Sciences, USA
A Roadmap to the Living Genome

Monday, January 30 | 5:00PM - 7:00PM
From Epigenomics to Disease
Room: Grand Ballroom CD

Speaker 5 of 5
Daniel S. Day, Whitehead Institute, USA
Short Talk: Tumor Progression through Sequential Disruption of Insulated Neighborhoods

Monday, January 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Ballroom AB
No registration fees are used to fund alcohol served at this function.

Monday, January 30 | 7:30PM - 10:00PM
Poster Session 1
Room: Grand Ballroom AB


Tuesday, January 31 | 7:30AM - 8:30AM
Breakfast
Room: Grand Ballroom AB


Tuesday, January 31 | 8:30AM - 11:45AM
Epigenetic Modification Dynamics: Gateway to Understanding D
isease

Room: Grand Ballroom CD

Speaker 1 of 8
* Jessica K. Tyler, Weill Cornell Medicine, USA

Tuesday, January 31 | 8:30AM - 11:45AM
Epigenetic Modification Dynamics: Gateway to Understanding D
isease

Room: Grand Ballroom CD

Speaker 2 of 8
Henk G. Stunnenberg, Radboud University, Netherlands
Epigenomics Uncovers Dysregulated Regulatory Pathways

Tuesday, January 31 | 8:30AM - 11:45AM
Epigenetic Modification Dynamics: Gateway to Understanding D
isease

Room: Grand Ballroom CD

Speaker 3 of 8
Shelley L. Berger, University of Pennsylvania, USA
Histone Acetylation Pathways in Learning and Memory

Tuesday, January 31 | 8:30AM - 11:45AM
Epigenetic Modification Dynamics: Gateway to Understanding D
isease

Room: Grand Ballroom CD


Coffee Break

Tuesday, January 31 | 8:30AM - 11:45AM
Epigenetic Modification Dynamics: Gateway to Understanding D
isease

Room: Grand Ballroom CD

Speaker 5 of 8
Anne Schaefer, Mount Sinai School of Medicine, USA
Polycomb Repressive Complex 2 (PRC2) Silences Genes Responsible for Neurodegeneration

Tuesday, January 31 | 8:30AM - 11:45AM
Epigenetic Modification Dynamics: Gateway to Understanding D
isease

Room: Grand Ballroom CD

Speaker 6 of 8
Robert E. Kingston, Massachusetts General Hospital, USA
Nucleosome Compaction as a Regulatory Mechanism during Development

Tuesday, January 31 | 8:30AM - 11:45AM
Epigenetic Modification Dynamics: Gateway to Understanding D
isease

Room: Grand Ballroom CD

Speaker 7 of 8
Panagiotis Ntziachristos, Northwestern University, USA
Short Talk: Targeting Deubiquitination in Acute Leukemia

Tuesday, January 31 | 8:30AM - 11:45AM
Epigenetic Modification Dynamics: Gateway to Understanding D
isease

Room: Grand Ballroom CD

Speaker 8 of 8
Woojin An, University of Southern California, USA
Short Talk: MacroH2A Suppresses Prostate Cancer Bone Metastasis through Cooperation with HP1 and H1.2

Tuesday, January 31 | 11:45AM - 5:00PM
On Own for Lunch


Tuesday, January 31 | 11:45AM - 1:00PM
Poster Setup
Room: Grand Ballroom AB


Tuesday, January 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Ballroom AB


Tuesday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Ballroom Foyer


Tuesday, January 31 | 5:00PM - 7:00PM
Chromatin Modifiers, Development and Disease
Room: Grand Ballroom CD

Speaker 1 of 6
* Anne Schaefer, Mount Sinai School of Medicine, USA

Tuesday, January 31 | 5:00PM - 7:00PM
Chromatin Modifiers, Development and Disease
Room: Grand Ballroom CD

Speaker 2 of 6
Jessica K. Tyler, Weill Cornell Medicine, USA
Chromatin Assembly and Disassembly

Tuesday, January 31 | 5:00PM - 7:00PM
Chromatin Modifiers, Development and Disease
Room: Grand Ballroom CD

Speaker 3 of 6
Johnathan R. Whetstine, Fox Chase Cancer Center, USA
Epigenetic Mechanisms Impact Cell Cycle and Somatic DNA Copy Number

Tuesday, January 31 | 5:00PM - 7:00PM
Chromatin Modifiers, Development and Disease
Room: Grand Ballroom CD

Speaker 4 of 6
Peter W. Lewis, University of Wisconsin-Madison, USA
Short Talk: H3 K36M Oncohistone Promotes Sarcomagenesis through Altered Methylation Landscape

Tuesday, January 31 | 5:00PM - 7:00PM
Chromatin Modifiers, Development and Disease
Room: Grand Ballroom CD

Speaker 5 of 6
David M. Truong, New York University Langone Medical Center, USA
Short Talk: Resetting the Yeast Epigenome with Human Nucleosomes

Tuesday, January 31 | 5:00PM - 7:00PM
Chromatin Modifiers, Development and Disease
Room: Grand Ballroom CD

Speaker 6 of 6
Kimberly J. Cocce, Duke University, USA
Short Talk: Genome Wide Profiling Identifies a FoxA1/GRHL2 Interaction that Functions as a Mediator of Endocrine Therapy Resistance in a Model of Luminal Breast Cancer

Tuesday, January 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Ballroom AB
No registration fees are used to fund alcohol served at this function.

Tuesday, January 31 | 7:30PM - 10:00PM
Poster Session 2
Room: Grand Ballroom AB


Wednesday, February 01 | 7:30AM - 8:30AM
Breakfast
Room: Grand Ballroom AB


Wednesday, February 01 | 8:00AM - 8:30AM
Poster Setup
Room: Grand Ballroom AB


Wednesday, February 01 | 8:30AM - 5:00PM
Poster Viewing
Room: Grand Ballroom AB


Wednesday, February 01 | 8:30AM - 11:45AM
Epigenetics and Cell States
Room: Grand Ballroom CD

Speaker 1 of 8
* François Fuks, Université Libre de Bruxelles, Belgium

Wednesday, February 01 | 8:30AM - 11:45AM
Epigenetics and Cell States
Room: Grand Ballroom CD

Speaker 2 of 8
Emily Bernstein, Mount Sinai School of Medicine, USA
Epigenetic Sensitivities in Cancer

Wednesday, February 01 | 8:30AM - 11:45AM
Epigenetics and Cell States
Room: Grand Ballroom CD

Speaker 3 of 8
Luciano Di Croce, CRG - Center for Genomic Regulation, Spain
Unveiling Polycomb Functions in Stem Cells and Cancer

Wednesday, February 01 | 8:30AM - 11:45AM
Epigenetics and Cell States
Room: Grand Ballroom CD


Coffee Break

Wednesday, February 01 | 8:30AM - 11:45AM
Epigenetics and Cell States
Room: Grand Ballroom CD

Speaker 5 of 8
Maria-Elena Torres-Padilla, Helmholtz Centre Munich, Germany
Epigenetic Mechanisms in Early Mammalian Development

Wednesday, February 01 | 8:30AM - 11:45AM
Epigenetics and Cell States
Room: Grand Ballroom CD

Speaker 6 of 8
Gerald R. Crabtree, Stanford University, USA
Chromatin Remodeling: Insights from the Genetics of Human Disease and New Methods

Wednesday, February 01 | 8:30AM - 11:45AM
Epigenetics and Cell States
Room: Grand Ballroom CD

Speaker 7 of 8
Elizabeth Heller, University of Pennsylvania, USA
Short Talk: Targeted Neuroepigenetic Editing of Cdk5 Regulates Behavior

Wednesday, February 01 | 8:30AM - 11:45AM
Epigenetics and Cell States
Room: Grand Ballroom CD

Speaker 8 of 8
Ana Patricia Gomes, Weill Cornell Medicine, USA
Short Talk: The CAF1 Complex Promotes Tumor Progression through Re-Distribution of Histone H3.3 in the Chromatin

Wednesday, February 01 | 11:45AM - 12:30PM
Lunch
Room: Grand Ballroom AB


Wednesday, February 01 | 12:00PM - 2:30PM
Poster Session 3
Room: Grand Ballroom AB


Wednesday, February 01 | 2:30PM - 4:30PM
Workshop: Breakthroughs in Technology and Disease
Room: Grand Ballroom CD

Speaker 1 of 9
* Cheryl Arrowsmith, University of Toronto, Canada

Wednesday, February 01 | 2:30PM - 4:30PM
Workshop: Breakthroughs in Technology and Disease
Room: Grand Ballroom CD

Speaker 2 of 9
Hatice Efsun Arda, National Institutes of Health, USA
Lineage Specific Regulomes of the Human Pancreas

Wednesday, February 01 | 2:30PM - 4:30PM
Workshop: Breakthroughs in Technology and Disease
Room: Grand Ballroom CD

Speaker 3 of 9
Manfred Jung, University of Freiburg, Germany
Chemical Tools for Methyl Lysine Readers

Wednesday, February 01 | 2:30PM - 4:30PM
Workshop: Breakthroughs in Technology and Disease
Room: Grand Ballroom CD

Speaker 4 of 9
Victoria T. Le, New York Genome Center, USA
Finding Translocations in Cancer Genomes using Chromatin Interaction Data

Wednesday, February 01 | 2:30PM - 4:30PM
Workshop: Breakthroughs in Technology and Disease
Room: Grand Ballroom CD

Speaker 5 of 9
Tonya Marie Gilbert, Massachusetts General Hospital, USA
In vivo HDAC Imaging in Schizophrenia using Combined MR-PET

Wednesday, February 01 | 2:30PM - 4:30PM
Workshop: Breakthroughs in Technology and Disease
Room: Grand Ballroom CD

Speaker 6 of 9
Ari Allyn-Feuer, University of Michigan Medical School, USA
The Pharmacogenomics Informatics Pipeline: An Integrative Multi-Omics Platform for Variant Discovery

Wednesday, February 01 | 2:30PM - 4:30PM
Workshop: Breakthroughs in Technology and Disease
Room: Grand Ballroom CD

Speaker 7 of 9
Nabieh Ayoub, Technion -Israel Institute of Technology, Israel
Characterizing the Biological Functions of KDM4A-D Interactions with RNA Molecules

Wednesday, February 01 | 2:30PM - 4:30PM
Workshop: Breakthroughs in Technology and Disease
Room: Grand Ballroom CD

Speaker 8 of 9
Shinya Oki, Kyoto University, Japan
The Transcription Factor Landscape Decodes the Enhancers and Risk Variants in Non-Coding Regions

Wednesday, February 01 | 2:30PM - 4:30PM
Workshop: Breakthroughs in Technology and Disease
Room: Grand Ballroom CD

Speaker 9 of 9
Yael David, Memorial Sloan Kettering Cancer Center, USA
Towards Synthetic Chromatin: Modifying Histones In Live Cells Using Protein Trans-Splicing

Wednesday, February 01 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Ballroom Foyer


Wednesday, February 01 | 5:00PM - 7:15PM
Epigenetic States and RNA
Room: Grand Ballroom CD

Speaker 1 of 6
* Emily Bernstein, Mount Sinai School of Medicine, USA

Wednesday, February 01 | 5:00PM - 7:15PM
Epigenetic States and RNA
Room: Grand Ballroom CD

Speaker 2 of 6
Tony Kouzarides, University of Cambridge, UK
Modifications of RNA: Their Function and Role in Cancer

Wednesday, February 01 | 5:00PM - 7:15PM
Epigenetic States and RNA
Room: Grand Ballroom CD

Speaker 3 of 6
Ramin Shiekhattar, University of Miami, USA
Targeting Integrator in Cancer

Wednesday, February 01 | 5:00PM - 7:15PM
Epigenetic States and RNA
Room: Grand Ballroom CD

Speaker 4 of 6
Ali Shilatifard, Northwestern University, USA
Principles of Epigenetics and Chromatin in Development and Human Disease

Wednesday, February 01 | 5:00PM - 7:15PM
Epigenetic States and RNA
Room: Grand Ballroom CD

Speaker 5 of 6
François Fuks, Université Libre de Bruxelles, Belgium
Short Talk: Transcriptome-Wide Distribution and Function of RNA Hydroxymethylcytosine

Wednesday, February 01 | 5:00PM - 7:15PM
Epigenetic States and RNA
Room: Grand Ballroom CD

Speaker 6 of 6
Guillermo Barreto, Max Planck Institute for Heart and Lung Research, Germany
Short Talk: Nuclear miRNA/exosome-Mediated Transcriptional Silencing within the Context of TGFB1 Signaling and Idiopathic Pulmonary Fibrosis

Wednesday, February 01 | 7:15PM - 7:15PM
On Own for Dinner


Thursday, February 02 | 7:30AM - 8:30AM
Breakfast
Room: Grand Ballroom AB


Thursday, February 02 | 8:30AM - 11:45AM
Targeting Epigenetics
Room: Grand Ballroom CD

Speaker 1 of 8
* Johnathan R. Whetstine, Fox Chase Cancer Center, USA

Thursday, February 02 | 8:30AM - 11:45AM
Targeting Epigenetics
Room: Grand Ballroom CD

Speaker 2 of 8
Rab K. Prinjha, GlaxoSmithKline, UK
Clinical Progression of BET Inhibitors

Thursday, February 02 | 8:30AM - 11:45AM
Targeting Epigenetics
Room: Grand Ballroom CD

Speaker 3 of 8
Cheryl Arrowsmith, University of Toronto, Canada
Probing the Epigenome for New Therapeutic Opportunities

Thursday, February 02 | 8:30AM - 11:45AM
Targeting Epigenetics
Room: Grand Ballroom CD


Coffee Break

Thursday, February 02 | 8:30AM - 11:45AM
Targeting Epigenetics
Room: Grand Ballroom CD

Speaker 5 of 8
Alexander Tarakhovsky, Rockefeller University, USA
Uncovering Histone Mimics and Disease

Thursday, February 02 | 8:30AM - 11:45AM
Targeting Epigenetics
Room: Grand Ballroom CD

Speaker 6 of 8
Jesse J. Smith, Omega Therapeutics, USA
The EZH2 Inhibitor Tazemetostat as a Potential Therapeutic for Non-Hodgkin Lymphoma and Genetically Defined Solid Tumors

Thursday, February 02 | 8:30AM - 11:45AM
Targeting Epigenetics
Room: Grand Ballroom CD

Speaker 7 of 8
Norman Wong, Resverlogix Corp, Canada
Short Talk: Selective BET Inhibitors are Useful for Normalizing Inflammation Leading to Reduced Cardiovascular Disease (CVD) in Humans and in an Animal Model of Rheumatoid Arthritis

Thursday, February 02 | 8:30AM - 11:45AM
Targeting Epigenetics
Room: Grand Ballroom CD

Speaker 8 of 8
Shaokun Shu, Dana-Farber Cancer Institute, USA
Short Talk: Response and Resistance to BET Bromodomain Inhibitors in Triple Negative Breast Cancer

Thursday, February 02 | 11:45AM - 5:00PM
On Own for Lunch


Thursday, February 02 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Ballroom Foyer


Thursday, February 02 | 5:00PM - 6:45PM
Epigenetics and Therapy
Room: Grand Ballroom CD

Speaker 1 of 4
* Rab K. Prinjha, GlaxoSmithKline, UK

Thursday, February 02 | 5:00PM - 6:45PM
Epigenetics and Therapy
Room: Grand Ballroom CD

Speaker 2 of 4
Tamara Maes, Oryzon Genomics, Spain
Development of Lysine-Specific Demethylase Inhibitors for Oncological and Neurodegenerative Disease

Thursday, February 02 | 5:00PM - 6:45PM
Epigenetics and Therapy
Room: Grand Ballroom CD

Speaker 3 of 4
Erica Korb, Rockefeller University, USA
Short Talk: Treatment of Fragile X Syndrome with the BET Inhibitor Jq1

Thursday, February 02 | 5:00PM - 6:45PM
Epigenetics and Therapy
Room: Grand Ballroom CD

Speaker 4 of 4
Dineo Khabele, Vanderbilt University, USA
Novel Epigenetic Drug Regimens to Enhance PARP Inhibitor Efficacy in Ovarian Cancer

Thursday, February 02 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grand Ballroom CD


Thursday, February 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Ballroom AB
No registration fees are used to fund alcohol served at this function.

Thursday, February 02 | 8:00PM - 11:00PM
Entertainment
Room: Grand Ballroom AB
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 02 | 8:00PM - 11:00PM
Cash Bar
Room: Grand Ballroom AB


Friday, February 03 | 10:25AM - 10:25AM
Departure


*Session Chair.