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Web Desc
Hematopoiesis
Organizer(s): Catriona H.M. Jamieson, Andreas Trumpp and Paul S. Frenette
Date: January 31 - February 04, 2017
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by Bayer HealthCare Pharmaceuticals
Summary of Meeting:
Since the discovery that hematopoiesis could be established by a single cell over five decades ago, advances in model systems, sequencing, reprogramming and genome editing technologies have enabled precise molecular characterization of regulators of hematopoiesis. These discoveries have informed and accelerated implementation of clinical trials for a broad array of benign and malignant hematologic disorders, including bone marrow failure syndromes and leukemia, as well as guided the development of molecular prognostication strategies. This Keystone Symposia meeting will bring together basic, translational and clinical researchers to discuss key regulators of hematopoietic stem and progenitor cell ontogeny, cell fate specification and self-renewal during homeostasis, stress and malignant transformation. The relative importance of cell-autonomous genetic, epigenetic, transcriptional and post-transcriptional hematopoietic regulatory mechanisms as well as local niche or systemic factors will be presented by international leaders in the field of hematopoiesis and stem cell biology. The culmination of innovative genome editing, reprogramming, single-cell sequencing and imaging in different model systems to unravel essential regulators of hematopoiesis will be highlighted. This meeting should provide a vital opportunity for forging collaborations between researchers from disparate disciplines and result in novel insights from a plethora of model systems that will enable investigators to address basic, translational and clinical hematopoiesis research challenges.
Scholarship Deadline: October 4 2016
Discounted Abstract Deadline: October 4 2016
Abstract Deadline: November 1 2016
Discounted Registration Deadline: December 1 2016
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer HealthCare Pharmaceuticals
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK112658-01
Funding for this conference was made possible (in part) by 1 R13 DK0109587-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 31 | 4:00PM - 8:00PM
Arrival and Registration
Room: Van Horne Foyer


Tuesday, January 31 | 6:00PM - 8:00PM
Welcome Mixer
Room: Van Horne Foyer
No registration fees are used to fund alcohol served at this function.

Wednesday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne B


Wednesday, February 01 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Van Horne A

Speaker 1 of 2
* Catriona H.M. Jamieson, University of California, San Diego, USA

Wednesday, February 01 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Van Horne A

Speaker 2 of 2
Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Pathways Regulating Stem Cell Induction, Self-Renewal and Engraftment

Wednesday, February 01 | 9:00AM - 11:30AM
Development
Room: Van Horne A

Speaker 1 of 8
* Catriona H.M. Jamieson, University of California, San Diego, USA

Wednesday, February 01 | 9:00AM - 11:30AM
Development
Room: Van Horne A

Speaker 2 of 8
David Traver, University of California, San Diego, USA
Birth of Stem Cell

Wednesday, February 01 | 9:00AM - 11:30AM
Development
Room: Van Horne A


Coffee Break

Wednesday, February 01 | 9:00AM - 11:30AM
Development
Room: Van Horne A

Speaker 4 of 8
Robert A.J. Signer, University of California, San Diego, USA
Translational Control of Hematopoietic Stem Cells

Wednesday, February 01 | 9:00AM - 11:30AM
Development
Room: Van Horne A

Speaker 5 of 8
Nina Cabezas-Wallscheid, German Cancer Research Center, Germany
Short Talk: Vitamin A/Retinoic Acid Signaling Regulates the Dormancy State of Hematopoietic Stem Cells

Wednesday, February 01 | 9:00AM - 11:30AM
Development
Room: Van Horne A

Speaker 6 of 8
Leslie A. Crews, University of California, San Diego, USA
Short Talk: Decoding the RNA Editome of Normal versus Malignant Hematopoietic Progenitor Cell Aging

Wednesday, February 01 | 9:00AM - 11:30AM
Development
Room: Van Horne A

Speaker 7 of 8
Linda T. Vo, University of California, San Francisco, USA
Short Talk: Unlocking Definitive Hematopoietic Potential via Epigenetic Modulation

Wednesday, February 01 | 9:00AM - 11:30AM
Development
Room: Van Horne A

Speaker 8 of 8
Lucas Greder, University of Oxford, UK
Short Talk: Chromatin Accessibility and Expression Profiling of the Endothelial-to-Hematopoietic Transition

Wednesday, February 01 | 11:30AM - 5:00PM
On Own for Lunch


Wednesday, February 01 | 11:30AM - 1:00PM
Poster Setup
Room: Van Horne B


Wednesday, February 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Van Horne B


Wednesday, February 01 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, February 01 | 5:00PM - 7:00PM
HSC Versus Progenitor Contribution to Hematopoiesis
Room: Van Horne A

Speaker 1 of 5
* Andreas Trumpp, German Cancer Research Center, Germany

Wednesday, February 01 | 5:00PM - 7:00PM
HSC Versus Progenitor Contribution to Hematopoiesis
Room: Van Horne A

Speaker 2 of 5
John E. Dick, Princess Margaret Cancer Centre, Canada
Mechanistic Insight Into Human Hematopoietic Lineage Determination

Wednesday, February 01 | 5:00PM - 7:00PM
HSC Versus Progenitor Contribution to Hematopoiesis
Room: Van Horne A

Speaker 3 of 5
Adolfo Ferrando, Columbia University, USA
Mechanisms of Clonal Evolution and Relapse in Acute Lymphoblastic Leukemia

Wednesday, February 01 | 5:00PM - 7:00PM
HSC Versus Progenitor Contribution to Hematopoiesis
Room: Van Horne A

Speaker 4 of 5
Alejo Ezequiel Rodriguez Fraticelli, Boston Children's Hospital, USA
Clonal Analysis of Hematopoietic Development

Wednesday, February 01 | 5:00PM - 7:00PM
HSC Versus Progenitor Contribution to Hematopoiesis
Room: Van Horne A

Speaker 5 of 5
Bilyana Stoilova, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Short Talk: Functional and Transcriptional Heterogeneity of Human Hemopoietic Lympho-Myeloid Progenitors at the Single Cell Level

Wednesday, February 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne B
No registration fees are used to fund alcohol served at this function.

Wednesday, February 01 | 7:30PM - 10:00PM
Poster Session 1
Room: Van Horne B


Thursday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne B


Thursday, February 02 | 8:00AM - 11:15AM
Microenvironment
Room: Van Horne A

Speaker 1 of 7
* Paul S. Frenette, Albert Einstein College of Medicine, USA
HSC Niche and its Regulation by Long-Range Signals


Thursday, February 02 | 8:00AM - 11:15AM
Microenvironment
Room: Van Horne A

Speaker 2 of 7
David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Hematopoietic Cell Fate is Clone Specific and Epigenetically Constrained: Implications for Concepts of the Bone Marrow Niche

Thursday, February 02 | 8:00AM - 11:15AM
Microenvironment
Room: Van Horne A


Coffee Break

Thursday, February 02 | 8:00AM - 11:15AM
Microenvironment
Room: Van Horne A

Speaker 4 of 7
Emmanuelle Passegué, Columbia University, USA
Niche Maintenance of Malignant Hematopoiesis

Thursday, February 02 | 8:00AM - 11:15AM
Microenvironment
Room: Van Horne A

Speaker 5 of 7
Irving L. Weissman, Stanford University, USA
Targeting Don’t Eat Me Signals in Malignant Hematopoiesis

Thursday, February 02 | 8:00AM - 11:15AM
Microenvironment
Room: Van Horne A

Speaker 6 of 7
Laura M. Calvi, University of Rochester Medical Center, USA
Short Talk: Age-and Region-Dependent Architectural Remodeling of Niche Constituents in the Hematopoietic Microenvironment Contributes to Hematopoietic Stem Cell Aging

Thursday, February 02 | 8:00AM - 11:15AM
Microenvironment
Room: Van Horne A

Speaker 7 of 7
Michael Poulos, Weill Cornell Medical College, USA
Short Talk: Rejuvenation of the Aged Vascular Niche to Enhance Hematopoietic Function

Thursday, February 02 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, February 02 | 11:15AM - 1:00PM
Poster Setup
Room: Van Horne B


Thursday, February 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Van Horne B


Thursday, February 02 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, February 02 | 5:00PM - 7:15PM
Epigenetics and Transcription
Room: Van Horne A

Speaker 1 of 4
Andreas Trumpp, German Cancer Research Center, Germany
Human Haematopoietic Stem Cell Differentiation is a Continuous Process without Discrete Progenitor Populations

Thursday, February 02 | 5:00PM - 7:15PM
Epigenetics and Transcription
Room: Van Horne A

Speaker 2 of 4
* Maria E. Figueroa, University of Miami Miller School of Medicine, USA
Epigenetic Deregulation in the Aging Hematopoietic Stem Cell

Thursday, February 02 | 5:00PM - 7:15PM
Epigenetics and Transcription
Room: Van Horne A

Speaker 3 of 4
Scott A. Armstrong, Dana-Farber Cancer Institute, USA
Histone Modifications and Gene Expression in Leukemia

Thursday, February 02 | 5:00PM - 7:15PM
Epigenetics and Transcription
Room: Van Horne A

Speaker 4 of 4
Iannis Aifantis, New York University School of Medicine, USA
The Missing Lncs: Regulation of Blood Cell Transformation by LncRNAs

Thursday, February 02 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Van Horne B
No registration fees are used to fund alcohol served at this function.

Thursday, February 02 | 7:30PM - 10:00PM
Poster Session 2
Room: Van Horne B


Friday, February 03 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne B


Friday, February 03 | 8:00AM - 11:00AM
Directed Differentiation and Expansion
Room: Van Horne A

Speaker 1 of 7
* E. Camilla Forsberg, University of California, Santa Cruz, USA
Bloody Commitments: Hematopoietic Stem Cell Fate Decisions

Friday, February 03 | 8:00AM - 11:00AM
Directed Differentiation and Expansion
Room: Van Horne A

Speaker 2 of 7
Derrick J. Rossi, Harvard University, USA
Diminished Apoptotic Priming Underlies Increased Survival of Aged Hematopoietic Stem Cells in Response to DNA Damage

Friday, February 03 | 8:00AM - 11:00AM
Directed Differentiation and Expansion
Room: Van Horne A


Coffee Break

Friday, February 03 | 8:00AM - 11:00AM
Directed Differentiation and Expansion
Room: Van Horne A

Speaker 4 of 7
Dan S. Kaufman, University of California, San Diego, USA
Pluripotent Stem Cells to Model Human Hemato-Lymphoid Development

Friday, February 03 | 8:00AM - 11:00AM
Directed Differentiation and Expansion
Room: Van Horne A

Speaker 5 of 7
Melanie Mumau, University of Pennsylvania, USA
Short Talk: NR4A1 Identifies a Population of Multipotent Progenitors in the Spleen that Restrict Erythropoiesis

Friday, February 03 | 8:00AM - 11:00AM
Directed Differentiation and Expansion
Room: Van Horne A

Speaker 6 of 7
Gabriela Pregernig, Decibel Therapeutics, USA
Short Talk: GATA1 and The Cohesin Complex Cooperate to Regulate Erythroid Gene expression

Friday, February 03 | 8:00AM - 11:00AM
Directed Differentiation and Expansion
Room: Van Horne A

Speaker 7 of 7
Katie Matatall, Baylor College of Medicine, USA
Short Talk: Batf2 is a Mediator of Stress-Induced Terminal Differentiation Driving Hematopoietic Stem Cell Depletion Following Chronic Infection

Friday, February 03 | 11:00AM - 5:00PM
On Own for Lunch


Friday, February 03 | 11:00AM - 1:00PM
Poster Setup
Room: Van Horne B


Friday, February 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Van Horne B


Friday, February 03 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Friday, February 03 | 5:00PM - 7:00PM
Genome and Transcriptome Editing in Normal and Malignant Pro
genitors

Room: Van Horne A

Speaker 1 of 5
* Derrick J. Rossi, Harvard University, USA

Friday, February 03 | 5:00PM - 7:00PM
Genome and Transcriptome Editing in Normal and Malignant Pro
genitors

Room: Van Horne A

Speaker 2 of 5
Catriona H.M. Jamieson, University of California, San Diego, USA
RNA Editing and Malignant Reprogramming

Friday, February 03 | 5:00PM - 7:00PM
Genome and Transcriptome Editing in Normal and Malignant Pro
genitors

Room: Van Horne A

Speaker 3 of 5
Carlo M. Croce, Ohio State University, USA
MicroRNA Dysregulation to Identify Therapeutic Targets

Friday, February 03 | 5:00PM - 7:00PM
Genome and Transcriptome Editing in Normal and Malignant Pro
genitors

Room: Van Horne A

Speaker 4 of 5
Daniel G. Tenen, Cancer Science Institute, Singapore
Regulation of Myeloid Transcription Factors, DNA Methylation and Leukemia by Noncoding RNA

Friday, February 03 | 5:00PM - 7:00PM
Genome and Transcriptome Editing in Normal and Malignant Pro
genitors

Room: Van Horne A

Speaker 5 of 5
Laura PMH de Rooij, McMaster University, Canada
Short Talk: Unraveling the Importance of RNA Binding Proteins in Leukemic Stem Cells by CRISPR-Cas9 Screening

Friday, February 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne B
No registration fees are used to fund alcohol served at this function.

Friday, February 03 | 7:30PM - 10:00PM
Poster Session 3
Room: Van Horne B


Saturday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne B


Saturday, February 04 | 8:00AM - 11:15AM
Hematopoietic Malignancies
Room: Van Horne A

Speaker 1 of 7
Ravi Majeti, Stanford University, USA
Stem Cells in Human AML

Saturday, February 04 | 8:00AM - 11:15AM
Hematopoietic Malignancies
Room: Van Horne A

Speaker 2 of 7
* Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA
Clonal Hematopoiesis during Aging

Saturday, February 04 | 8:00AM - 11:15AM
Hematopoietic Malignancies
Room: Van Horne A


Coffee Break

Saturday, February 04 | 8:00AM - 11:15AM
Hematopoietic Malignancies
Room: Van Horne A

Speaker 4 of 7
Tannishtha Reya, University of California, San Diego, USA
In vivo Imaging of Regulators of Normal and Leukemia Stem Cell Symmetric and Asymmetric Division

Saturday, February 04 | 8:00AM - 11:15AM
Hematopoietic Malignancies
Room: Van Horne A

Speaker 5 of 7
Luigi M. Naldini, San Raffaele Telethon Institute, Italy
Genetic Engineering of Hematopoiesis for Treating Human Diseases

Saturday, February 04 | 8:00AM - 11:15AM
Hematopoietic Malignancies
Room: Van Horne A

Speaker 6 of 7
Toshio Kitamura, University of Tokyo, Institute of Medical Science, Japan
Short Talk: Disruption of EZH2 Induces Myelodysplastc Syndromes (MDS) in Mice via Derepression of ABC-G2

Saturday, February 04 | 8:00AM - 11:15AM
Hematopoietic Malignancies
Room: Van Horne A

Speaker 7 of 7
Virginia Turati, UCL Cancer Institute, UK
Short Talk: Single-Cell Analysis of Clonal Dynamics of childhood ALL

Saturday, February 04 | 11:15AM - 5:00PM
On Own for Lunch


Saturday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Saturday, February 04 | 5:00PM - 6:45PM
DNA Damage, Repair and Aging
Room: Van Horne A

Speaker 1 of 3
* Amy J. Wagers, Harvard University, USA
Intrinsic and Extrinsic Signals Regulating Stem Cell Aging

Saturday, February 04 | 5:00PM - 6:45PM
DNA Damage, Repair and Aging
Room: Van Horne A

Speaker 2 of 3
Michael D. Milsom, HI-STEM/DKFZ, Germany
A Rude Awakening: Stem Cell Depletion in Response to Stress.

Saturday, February 04 | 5:00PM - 6:45PM
DNA Damage, Repair and Aging
Room: Van Horne A

Speaker 3 of 3
Elaine R. Mardis, Nationwide Children's Hospital, USA
AML Genomics: Clinical Translation from Large-Scale Discovery

Saturday, February 04 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Van Horne A


Saturday, February 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne B
No registration fees are used to fund alcohol served at this function.

Saturday, February 04 | 8:00PM - 11:00PM
Entertainment
Room: Van Horne B
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Saturday, February 04 | 8:00PM - 11:00PM
Cash Bar
Room: Van Horne B


Sunday, February 05 | 10:25AM - 10:25AM
Departure


*Session Chair.