Web Desc
Viral Immunity: Mechanisms and Consequences
Organizer(s): Akiko Iwasaki, Daniel B. Stetson and E. John Wherry
Date: February 19 - 23, 2017
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Sponsored by Gilead Sciences, Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
A clear understanding of the mechanisms of host immunity to virus infection will guide efforts to design better treatments for some of the most devastating diseases of humanity. The fields of virology and immunology often convene their own specialized meetings. However, each of these fields has matured to the point where the most transformative advances are likely to arise from cross-disciplinary insights, rather than from continued progress in an isolated area. This meeting will foster new interactions and generate new ideas by assembling international experts in the areas of evolutionary perspectives on the host-virus relationship, innate immune detection and control of endogenous and exogenous viruses, memory cell control of viruses at mucosal surfaces, immunological consequences of prior viral exposure, and new approaches to vaccines and therapeutics. This comprehensive and inclusive approach should spur new thinking. For example, a solution to the medically important issue of chronic viral infection and immune exhaustion may emerge from a better understanding of the history of these viruses and how they have shaped the immune response and vice versa over evolutionary time. Similarly, a rational approach to vaccine design must be rooted in the innate immune mechanisms by which cells detect and respond to virus infection. This Keystone Symposia meeting offers a unique opportunity to bring about the next advances in viral immunity through cross-disciplinary interactions.
Scholarship Deadline: October 18 2016
Discounted Abstract Deadline: October 18 2016
Abstract Deadline: November 17 2016
Discounted Registration Deadline: December 19 2016
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Gilead Sciences, Inc.
We gratefully acknowledge additional support for this conference from:
eLife
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI129343-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Promenade


Sunday, February 19 | 6:00PM - 8:00PM
Welcome Mixer
Room: Promenade
No registration fees are used to fund alcohol served at this function.

Monday, February 20 | 7:00AM - 8:00AM
Breakfast
Room: Pecos/Canyon


Monday, February 20 | 7:30AM - 8:00AM
Poster Setup
Room: Mesa C


Monday, February 20 | 8:00AM - 5:00PM
Poster Viewing
Room: Mesa C


Monday, February 20 | 8:00AM - 9:00AM
Welcome and Keynote Address (Organizers)
Room: Mesa A-B

Speaker 1 of 1
Stephen P. Goff, Columbia University, USA
Host Regulation of Retroviruses

Monday, February 20 | 9:00AM - 11:30AM
Sensing Endogenous Viruses
Room: Mesa A-B

Speaker 1 of 7
* Nels C. Elde, University of Utah, USA

Monday, February 20 | 9:00AM - 11:30AM
Sensing Endogenous Viruses
Room: Mesa A-B

Speaker 2 of 7
Daniel B. Stetson, University of Washington, USA
Regulating Endogenous Retroviral Sensing

Monday, February 20 | 9:00AM - 11:30AM
Sensing Endogenous Viruses
Room: Mesa A-B

Speaker 3 of 7
Marco De Cecco, Brown University, USA
Short Talk: LINE-1 Elements Escape Repression in Senescent Cells and Trigger a Type-I Interferon Response

Monday, February 20 | 9:00AM - 11:30AM
Sensing Endogenous Viruses
Room: Mesa A-B


Coffee Break

Monday, February 20 | 9:00AM - 11:30AM
Sensing Endogenous Viruses
Room: Mesa A-B

Speaker 5 of 7
Maria Tokuyama, Yale University School of Medicine, USA
Short Talk: Genome-Wide Endogenous Retrovirus Profiling Reveals Interferon-Independent Lupus Signature

Monday, February 20 | 9:00AM - 11:30AM
Sensing Endogenous Viruses
Room: Mesa A-B

Speaker 6 of 7
John V. Moran, University of Michigan Medical School, USA
Studies of a Human Retrotransposon

Monday, February 20 | 9:00AM - 11:30AM
Sensing Endogenous Viruses
Room: Mesa A-B

Speaker 7 of 7
George Kassiotis, Francis Crick Institute, UK
Immunity to Endogenous Retroviruses

Monday, February 20 | 11:30AM - 12:30PM
Lunch
Room: Pecos/Canyon


Monday, February 20 | 12:00PM - 2:30PM
Poster Session 1
Room: Mesa C


Monday, February 20 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 1 of 9
* Jennifer M. Lund, Fred Hutchinson Cancer Research Center, USA

Monday, February 20 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 2 of 9
Pavla Brachova, University of Kansas Medical Center, USA
RNA-Editing and Sensing in Mammalian Oocytes

Monday, February 20 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 3 of 9
Hannah Burgess, New York University School of Medicine, USA
The Stress Granule Component G3BP1 Opposes an HSV-1 Endoribonuclease to Regulate PKR Activation and Interferon Induction

Monday, February 20 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 4 of 9
Oya Cingoz, Columbia University Medical Center, USA
CDK Inhibition Blocks Nucleic Acid Induced Innate Immune Responses

Monday, February 20 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 5 of 9
Jessica Graham, Fred Hutchinson Cancer Research Center, USA
West Nile Virus Infection in the Collaborative Cross Mouse Model Recapitulates Unique Human Disease States

Monday, February 20 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 6 of 9
Tzachi Hagai, EMBL - European Bioinformatics Institute, UK
The Architecture of Cellular Antiviral Immunity

Monday, February 20 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 7 of 9
Tania Lebratti, Washington University in St. Louis, USA
Neutrophils Regulate Pathogenesis in Genital HSV-2 Infection

Monday, February 20 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 8 of 9
Takuma Shibata, Institute of Medical Science, University of Tokyo, Japan
Nucleosides are endogenous ligands for TLR7 and TLR8

Monday, February 20 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 9 of 9
Gilad Sivan, NIAID, National Institutes of Health, USA
A Reverse Evolution Approach for Identification of Novel Antiviral Pathways

Monday, February 20 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, February 20 | 5:00PM - 7:00PM
Evolutionary Arms Race with Viruses
Room: Mesa A-B

Speaker 1 of 5
* Daniel B. Stetson, University of Washington, USA

Monday, February 20 | 5:00PM - 7:00PM
Evolutionary Arms Race with Viruses
Room: Mesa A-B

Speaker 2 of 5
Nels C. Elde, University of Utah, USA
Retrogenes as Antivirals

Monday, February 20 | 5:00PM - 7:00PM
Evolutionary Arms Race with Viruses
Room: Mesa A-B

Speaker 3 of 5
Nicolas Manel, Institut Curie, France
Interactions of Dendritic Cells with Viruses

Monday, February 20 | 5:00PM - 7:00PM
Evolutionary Arms Race with Viruses
Room: Mesa A-B

Speaker 4 of 5
Rossana Colon-Thillet, Fred Hutchinson Cancer Research Center, USA
Short Talk: An Unbiased Approach to Evaluate the Contribution of Rapidly Evolving Sites at Antiviral Interfaces

Monday, February 20 | 5:00PM - 7:00PM
Evolutionary Arms Race with Viruses
Room: Mesa A-B

Speaker 5 of 5
Beatrice H. Hahn, University of Pennsylvania, USA
Determinants of HIV-1 Transmission Fitness

Monday, February 20 | 7:00PM - 7:00PM
On Own for Dinner


Tuesday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Pecos/Canyon


Tuesday, February 21 | 8:00AM - 11:15AM
Innate Antiviral Defense
Room: Mesa A-B

Speaker 1 of 8
* Ken H. Cadwell, New York University School of Medicine, USA

Tuesday, February 21 | 8:00AM - 11:15AM
Innate Antiviral Defense
Room: Mesa A-B

Speaker 2 of 8
Sara R. Cherry, University of Pennsylvania, USA
Cellular Factors that Regulate Viral Pathogenesis

Tuesday, February 21 | 8:00AM - 11:15AM
Innate Antiviral Defense
Room: Mesa A-B

Speaker 3 of 8
John W. Schoggins, University of Texas Southwestern Medical Center, USA
Modulation of Viral Infection by Interferon-Stimulated Genes

Tuesday, February 21 | 8:00AM - 11:15AM
Innate Antiviral Defense
Room: Mesa A-B

Speaker 4 of 8
Andrew Oberst, University of Washington, USA
Short Talk: Death-Independent Roles of the Necroptotic Pathway in the Restriction of Flavivirus Pathogenesis

Tuesday, February 21 | 8:00AM - 11:15AM
Innate Antiviral Defense
Room: Mesa A-B


Coffee Break

Tuesday, February 21 | 8:00AM - 11:15AM
Innate Antiviral Defense
Room: Mesa A-B

Speaker 6 of 8
Shomyseh Sanjabi, Gladstone Institutes, University of California, San Francisco, USA
Short Talk: Dampened Antiviral Immunity to Intravaginal Exposure to RNA Viral Pathogens Allows Enhanced Viral Replication

Tuesday, February 21 | 8:00AM - 11:15AM
Innate Antiviral Defense
Room: Mesa A-B

Speaker 7 of 8
Michael S. Diamond, Washington University School of Medicine, USA
Using Mouse Models to Study the Pathogenesis and Immune Response to Zika Virus

Tuesday, February 21 | 8:00AM - 11:15AM
Innate Antiviral Defense
Room: Mesa A-B

Speaker 8 of 8
Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Innate Antiviral Defense

Tuesday, February 21 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, February 21 | 11:15AM - 1:00PM
Poster Setup
Room: Mesa C


Tuesday, February 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Tuesday, February 21 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Tuesday, February 21 | 5:00PM - 7:00PM
Viral Sensors: Structure and Function
Room: Mesa A-B

Speaker 1 of 5
* Owen Pornillos, University of Virginia, USA

Tuesday, February 21 | 5:00PM - 7:00PM
Viral Sensors: Structure and Function
Room: Mesa A-B

Speaker 2 of 5
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
DNA Sensor

Tuesday, February 21 | 5:00PM - 7:00PM
Viral Sensors: Structure and Function
Room: Mesa A-B

Speaker 3 of 5
Sun Hur, Harvard Medical School, USA
Structure and Function of RNA Sensors

Tuesday, February 21 | 5:00PM - 7:00PM
Viral Sensors: Structure and Function
Room: Mesa A-B

Speaker 4 of 5
Seong-Wook Oh, Kyoto University, Japan
Short Talk: Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules

Tuesday, February 21 | 5:00PM - 7:00PM
Viral Sensors: Structure and Function
Room: Mesa A-B

Speaker 5 of 5
Toshiyuki Shimizu, University of Tokyo, Japan
Structural Study of TLRs Sensing Single-Stranded RNA in Innate Immune System

Tuesday, February 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pecos/Canyon
No registration fees are used to fund alcohol served at this function.

Tuesday, February 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Mesa C


Wednesday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Pecos/Canyon


Wednesday, February 22 | 8:00AM - 11:15AM
Memory Responses in Peripheral Tissue
Room: Mesa A-B

Speaker 1 of 8
* E. John Wherry, University of Pennsylvania, USA

Wednesday, February 22 | 8:00AM - 11:15AM
Memory Responses in Peripheral Tissue
Room: Mesa A-B

Speaker 2 of 8
Ulrich H. Von Andrian, Harvard Medical School, USA
Memory T Cells in the Uterus

Wednesday, February 22 | 8:00AM - 11:15AM
Memory Responses in Peripheral Tissue
Room: Mesa A-B

Speaker 3 of 8
Susan M. Kaech, The Salk Institute, USA
Memory T Cell Programming

Wednesday, February 22 | 8:00AM - 11:15AM
Memory Responses in Peripheral Tissue
Room: Mesa A-B

Speaker 4 of 8
Jessica K. Fiege, University of Minnesota, USA
Short Talk: How and Why Lung Epithelial Cells Survive Influenza A Virus Infection

Wednesday, February 22 | 8:00AM - 11:15AM
Memory Responses in Peripheral Tissue
Room: Mesa A-B


Coffee Break

Wednesday, February 22 | 8:00AM - 11:15AM
Memory Responses in Peripheral Tissue
Room: Mesa A-B

Speaker 6 of 8
Susan L. Swain, University of Massachusetts Medical School, USA
Short Talk: Ag Recognition at a Checkpoint During the CD4 Effector Phase Drives Generation of CD4 Memory  

Wednesday, February 22 | 8:00AM - 11:15AM
Memory Responses in Peripheral Tissue
Room: Mesa A-B

Speaker 7 of 8
Rachael A. Clark, Brigham and Women's Hospital, Harvard Medical School, USA
Resident Memory T cells in Human Health and Disease

Wednesday, February 22 | 8:00AM - 11:15AM
Memory Responses in Peripheral Tissue
Room: Mesa A-B

Speaker 8 of 8
Laura K. Mackay, University of Melbourne, Australia
Molecular Regulation of Tissue-Resident Lymphocytes

Wednesday, February 22 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, February 22 | 11:15AM - 1:00PM
Poster Setup
Room: Mesa C


Wednesday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Wednesday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Wednesday, February 22 | 5:00PM - 7:00PM
Consequences of Virus Infection on Immunity
Room: Mesa A-B

Speaker 1 of 5
* Sara R. Cherry, University of Pennsylvania, USA

Wednesday, February 22 | 5:00PM - 7:00PM
Consequences of Virus Infection on Immunity
Room: Mesa A-B

Speaker 2 of 5
Ken H. Cadwell, New York University School of Medicine, USA
Virus-Host Interactions and the Gut Microbiota


Wednesday, February 22 | 5:00PM - 7:00PM
Consequences of Virus Infection on Immunity
Room: Mesa A-B

Speaker 3 of 5
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Coinfection and Disease Tolerance

Wednesday, February 22 | 5:00PM - 7:00PM
Consequences of Virus Infection on Immunity
Room: Mesa A-B

Speaker 4 of 5
Megan T. Baldridge, Washington University School of Medicine, USA
Short Talk: Interferon-lambda Responses to Norovirus Infection are Mediated Through Epithelial Cell Signaling and Governed by HOIL-1

Wednesday, February 22 | 5:00PM - 7:00PM
Consequences of Virus Infection on Immunity
Room: Mesa A-B

Speaker 5 of 5
Tatyana V. Golovkina, University of Chicago, USA
Genetic Basis for the Inhibition of Retrovirus Neutralizing Antibody Responses

Wednesday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pecos/Canyon
No registration fees are used to fund alcohol served at this function.

Wednesday, February 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Mesa C


Thursday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Pecos/Canyon


Thursday, February 23 | 8:00AM - 11:15AM
Vaccines Against Viruses
Room: Mesa A-B

Speaker 1 of 8
* Ulrich H. Von Andrian, Harvard Medical School, USA

Thursday, February 23 | 8:00AM - 11:15AM
Vaccines Against Viruses
Room: Mesa A-B

Speaker 2 of 8
Galit Alter, MIT and Harvard University, USA
Exploiting the Adjuvanting Effects of Antibody Glycosylation in Vaccination

Thursday, February 23 | 8:00AM - 11:15AM
Vaccines Against Viruses
Room: Mesa A-B

Speaker 3 of 8
Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Universal Vaccines for Influenza Viruses

Thursday, February 23 | 8:00AM - 11:15AM
Vaccines Against Viruses
Room: Mesa A-B

Speaker 4 of 8
Nicolas Chevrier, Harvard University, USA
Short Talk: Organism-Level Analysis of Vaccination Reveals Networks of Protection Across Tissues

Thursday, February 23 | 8:00AM - 11:15AM
Vaccines Against Viruses
Room: Mesa A-B


Coffee Break

Thursday, February 23 | 8:00AM - 11:15AM
Vaccines Against Viruses
Room: Mesa A-B

Speaker 6 of 8
Jens P. Wrammert, Emory University, USA
Short Talk: Human Antibody Responses After Dengue Virus Infection are Highly Cross-Reactive to Zika Virus

Thursday, February 23 | 8:00AM - 11:15AM
Vaccines Against Viruses
Room: Mesa A-B

Speaker 7 of 8
Gary J. Nabel, Sanofi, USA
Novel Approaches to Broadly Neutralizing Ab Combinations for HIV Prevention and Treatment

Thursday, February 23 | 8:00AM - 11:15AM
Vaccines Against Viruses
Room: Mesa A-B

Speaker 8 of 8
Penny L. Moore, University of the Witwatersrand and National Institute for Communicable Diseases, South Africa
HIV Vaccines – Lessons from Infection

Thursday, February 23 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, February 23 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 1 of 9
* Tania H. Watts, University of Toronto, Canada

Thursday, February 23 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 2 of 9
Shannon Renee Barbour, University of Pennsylvania, USA
Defining the Specificity of Antibodies Elicited by Primary and Secondary Flavivirus Infections

Thursday, February 23 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 3 of 9
David R. Collins, Ragon Institute of MGH, MIT & Harvard, USA
Beyond Mutational Escape: Mechanisms of HIV Rebound After Control

Thursday, February 23 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 4 of 9
Brian J. Laidlaw, University of California, San Francisco, USA
The Eph-Related Tyrosine Kinase Ligand Ephrin-B1 Marks Germinal Center and Memory Precursor B Cells

Thursday, February 23 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 5 of 9
Yew Ann Leong, Monash University, Australia
CXCR5+ Follicular Cytotoxic T Cells Control Viral Infection in B Cell Follicles

Thursday, February 23 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 6 of 9
Michal Caspi Tal, Stanford University School of Medicine, USA
Host Dependent Upregulation of CD47 is a Critical Component of Antiviral Immune responses

Thursday, February 23 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 7 of 9
Andreas Wieland, Emory University, USA
Strategies for Efficient Fc{gamma}R-Mediated Antibody Effector Functions During Persistent Viral Infection

Thursday, February 23 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 8 of 9
Angela C. Zhou, University of Toronto, Canada
Intrinsic 4-1BB Signals are Indispensable for Establishment of an Influenza-Specific CD8 Tissue-Resident Memory T Cell Population in the Lung

Thursday, February 23 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 9 of 9
Vesselin T. Tomov, University of Pennsylvania, USA
Short Talk: Enteric MNV Persistence is Associated with a Unique CD8 T Cell Differentiation State and Rapid Immune Evasion

Thursday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Thursday, February 23 | 5:00PM - 6:15PM
Chronic Viral Infection
Room: Mesa A-B

Speaker 1 of 3
* Galit Alter, MIT and Harvard University, USA

Thursday, February 23 | 5:00PM - 6:15PM
Chronic Viral Infection
Room: Mesa A-B

Speaker 2 of 3
E. John Wherry, University of Pennsylvania, USA
Molecular Basis of T Cell Exhaustion: Insights for Immunotherapy

Thursday, February 23 | 5:00PM - 6:15PM
Chronic Viral Infection
Room: Mesa A-B

Speaker 3 of 3
Daniel C. Douek, NIAID, National Institutes of Health, USA
Multiple Origins of Virus Persistence in HIV Controllers

Thursday, February 23 | 6:15PM - 7:00PM
Closing Keynote Address
Room: Mesa A-B

Speaker 1 of 2
* E. John Wherry, University of Pennsylvania, USA

Thursday, February 23 | 6:15PM - 7:00PM
Closing Keynote Address
Room: Mesa A-B

Speaker 2 of 2
Rafi Ahmed, Emory University School of Medicine, USA
Defining Stem-Like CD8 T Cells that Respond to PD-1 Therapy

Thursday, February 23 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Mesa A-B


Thursday, February 23 | 8:15PM - 9:15PM
Social Hour with Lite Bites
Room: Promenade/Mesa Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, February 23 | 8:15PM - 11:00PM
Entertainment
Room: Mesa Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 23 | 9:15PM - 11:00PM
Cash Bar
Room: Mesa Ballroom


Friday, February 24 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.