Web Desc
Lipidomics and Bioactive Lipids in Metabolism and Disease
Organizer(s): Alfred H. Merrill, Walter Allen Shaw, Sarah Spiegel and Michael J.O.Wakelam
Date: February 26 - March 02, 2017
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Sponsored by Abide Therapeutics Inc.
Summary of Meeting:
The ability to analyze large numbers of lipids from different categories (e.g., fatty acyls, glycerolipids, sphingolipids and sterols) has greatly advanced our understanding of their biochemical functions and roles in disease, but has also created challenges of scale. This Keystone Symposia meeting will cover areas of lipid research that have been particularly impacted by these technologies. It will specifically address the challenge of managing the large data sets generated by lipidomic technologies and conceptually studying them given how interconnected and cross-regulated lipid metabolic pathways are. Bringing together an outstanding group of scientists with expertise in the lipid categories as well as in lipidomic approaches, it will summarize recent findings for the major lipid categories from state-of-the-art technologies and lay the foundation for a broader understanding of new methods and the technical capabilities and limitations of these methods, as well as where better approaches are needed.
Scholarship Deadline: October 26 2016
Discounted Abstract Deadline: October 26 2016
Abstract Deadline: December 12 2016
Discounted Registration Deadline: January 9 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Abide Therapeutics Inc.
We gratefully acknowledge additional support for this conference from:
Avanti Polar Lipids, Inc.Cayman Chemical CompanyJournal of Lipid ResearchLipotype GmbH
SCIEX, LLC
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Avanti Polar Lipids, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 26 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function


Sunday, February 26 | 6:00PM - 8:00PM
Welcome Mixer
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Sunday, February 26 | 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall


Monday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, February 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Organizers)
Room: Mountain/Lake

Speaker 1 of 1
Edward A. Dennis, University of California, San Diego, USA
Lipidomics Highlights Infection and Inflammation Progression

Monday, February 27 | 9:00AM - 11:30AM
Lipidomics in Inflammation
Room: Mountain/Lake

Speaker 1 of 8
* Alfred H. Merrill, Jr., Georgia Institute of Technology, USA

Monday, February 27 | 9:00AM - 11:30AM
Lipidomics in Inflammation
Room: Mountain/Lake

Speaker 2 of 8
* Sarah Spiegel, Virginia Commonwealth University, USA

Monday, February 27 | 9:00AM - 11:30AM
Lipidomics in Inflammation
Room: Mountain/Lake

Speaker 3 of 8
Garret A. FitzGerald, University of Pennsylvania, USA
Prostaglandins and Their Inhibitors

Monday, February 27 | 9:00AM - 11:30AM
Lipidomics in Inflammation
Room: Mountain/Lake


Coffee Break

Monday, February 27 | 9:00AM - 11:30AM
Lipidomics in Inflammation
Room: Mountain/Lake

Speaker 5 of 8
Valerie B. O'Donnell, Cardiff University, UK
Lipidomics Characterization of Oxidation during Platelet Activation and Physiological Blood Clotting

Monday, February 27 | 9:00AM - 11:30AM
Lipidomics in Inflammation
Room: Mountain/Lake

Speaker 6 of 8
Richard L. Proia, National Institutes of Health, USA
Visualizing Sphingosine-1-Phosphate G Protein-Coupled Receptor Signaling in Living Animals

Monday, February 27 | 9:00AM - 11:30AM
Lipidomics in Inflammation
Room: Mountain/Lake

Speaker 7 of 8
Charles E. Chalfant, Virginia Commonwealth University, School of Medicine, USA
Short Talk: The Lipidome in Inflammation, Wound Healing, and Pre-Eclampsia

Monday, February 27 | 9:00AM - 11:30AM
Lipidomics in Inflammation
Room: Mountain/Lake

Speaker 8 of 8
Veronica G. Anania, Genentech, Inc., USA
Short Talk: Bioactive Lipids as Pharmacodynamic Biomarkers of Mast Cell Activity in the Clinic

Monday, February 27 | 11:30AM - 11:45AM
Description of LIPID MAPS and Website Tools
Room: Mountain/Lake

Speaker 1 of 2
* Valerie B. O'Donnell, Cardiff University, UK

Monday, February 27 | 11:30AM - 11:45AM
Description of LIPID MAPS and Website Tools
Room: Mountain/Lake

Speaker 2 of 2
Eoin Fahy, University of California, San Diego, USA

Monday, February 27 | 11:30AM - 1:00PM
Poster Setup
Room: Bay


Monday, February 27 | 11:45AM - 5:00PM
On Own for Lunch


Monday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, February 27 | 5:00PM - 7:00PM
Lipidomics and Infection
Room: Mountain/Lake

Speaker 1 of 4
* Charles R. Brown, University of Missouri, USA

Monday, February 27 | 5:00PM - 7:00PM
Lipidomics and Infection
Room: Mountain/Lake

Speaker 2 of 4
Markus R. Wenk, National University of Singapore, Singapore
Natural Variation of Blood Plasma Lipids in Healthy Asian Individuals

Monday, February 27 | 5:00PM - 7:00PM
Lipidomics and Infection
Room: Mountain/Lake

Speaker 3 of 4
Dennis R. Voelker, National Jewish Health, USA
Journal of Lipid Research Lectureship: Pulmonary Surfactant Phospholipids Regulate Innate Immunity

Monday, February 27 | 5:00PM - 7:00PM
Lipidomics and Infection
Room: Mountain/Lake

Speaker 4 of 4
Frances Platt, University of Oxford, UK
The Niemann-Pick Type C Disease Pathway and its Unanticipated Role in Infection

Monday, February 27 | 7:15PM - 8:15PM
Dinner
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Monday, February 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay


Monday, February 27 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Tuesday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, February 28 | 8:00AM - 11:15AM
Cancer Lipidomics
Room: Mountain/Lake

Speaker 1 of 9
* Andrew J. Morris, University of Kentucky, USA

Tuesday, February 28 | 8:00AM - 11:15AM
Cancer Lipidomics
Room: Mountain/Lake

Speaker 2 of 9
* Markus R. Wenk, National University of Singapore, Singapore

Tuesday, February 28 | 8:00AM - 11:15AM
Cancer Lipidomics
Room: Mountain/Lake

Speaker 3 of 9
Sarah Spiegel, Virginia Commonwealth University, USA
Targeting the Sphingosine-1-Phosphate Axis and Development of a Novel Therapy for Endocrine-Resistant Breast Cancer

Tuesday, February 28 | 8:00AM - 11:15AM
Cancer Lipidomics
Room: Mountain/Lake

Speaker 4 of 9
Tony Futerman, Weizmann Institute of Science, Israel
Ceramide Synthases and Cellular Function

Tuesday, February 28 | 8:00AM - 11:15AM
Cancer Lipidomics
Room: Mountain/Lake


Coffee Break

Tuesday, February 28 | 8:00AM - 11:15AM
Cancer Lipidomics
Room: Mountain/Lake

Speaker 6 of 9
Michael J.O. Wakelam, Babraham Institute, UK
Lipidomic Changes Predict Novel Therapeutic Targets in Colorectal Cancer and Other Diseases

Tuesday, February 28 | 8:00AM - 11:15AM
Cancer Lipidomics
Room: Mountain/Lake

Speaker 7 of 9
Christian Metallo, University of California, San Diego, USA
Understanding the Interplay between Amino Acid and Lipid Metabolism

Tuesday, February 28 | 8:00AM - 11:15AM
Cancer Lipidomics
Room: Mountain/Lake

Speaker 8 of 9
Tzipora Goldkorn, University of California, Davis, USA
Short Talk: nSMase2 Conveys Oncogenic Advantages to Tumors of Lung Adenocarcinoma in Smokers via SphK1

Tuesday, February 28 | 8:00AM - 11:15AM
Cancer Lipidomics
Room: Mountain/Lake

Speaker 9 of 9
David A. Potter, University of Minnesota, USA
Short Talk: Heme Binding Biguanides Target Cytochrome P450 Dependent Cancer Cell Mitochondria

Tuesday, February 28 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, February 28 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, February 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, February 28 | 5:00PM - 7:15PM
Cardiovascular Lipidomics
Room: Mountain/Lake

Speaker 1 of 6
* Julian L. Griffin, University of Cambridge, UK

Tuesday, February 28 | 5:00PM - 7:15PM
Cardiovascular Lipidomics
Room: Mountain/Lake

Speaker 2 of 6
William Griffiths, Swansea University, UK
Oxysterol Lipidomics in Mouse and Man

Tuesday, February 28 | 5:00PM - 7:15PM
Cardiovascular Lipidomics
Room: Mountain/Lake

Speaker 3 of 6
L. Ashley Cowart, Virginia Commonwealth University, USA
Advances in Understanding the Roles of Ceramide Synthase Isoforms in the Cardiac Response to Dyslipidemia


Tuesday, February 28 | 5:00PM - 7:15PM
Cardiovascular Lipidomics
Room: Mountain/Lake

Speaker 4 of 6
Jeffrey G. McDonald, University of Texas Southwestern Medical Center, USA
Analysis of ELOVL Enzyme Activity by Infusion-Based Lipidomics Using MS/MSALL

Tuesday, February 28 | 5:00PM - 7:15PM
Cardiovascular Lipidomics
Room: Mountain/Lake

Speaker 5 of 6
Andrew J. Morris, University of Kentucky, USA
Short Talk: Lysophosphatidic Acid Metabolism and Signaling in Atherosclerosis

Tuesday, February 28 | 5:00PM - 7:15PM
Cardiovascular Lipidomics
Room: Mountain/Lake

Speaker 6 of 6
Rheem A. Totah, University of Washington, USA
Short Talk: cis- and trans-Epoxyeicosatrienoic Acids in Patients with Cardiovascular Disease

Tuesday, February 28 | 7:15PM - 7:30PM
Recognition of Scholarship Awardees
Room: Mountain/Lake

Speaker 1 of 3
* Alfred H. Merrill, Jr., Georgia Institute of Technology, USA

Tuesday, February 28 | 7:15PM - 7:30PM
Recognition of Scholarship Awardees
Room: Mountain/Lake

Speaker 2 of 3
Patricia Rodrigues, Cardiff University, UK
GATA6 Transcription Factor Regulates Lipid Metabolism in Tissue Resident Macrophages

Tuesday, February 28 | 7:15PM - 7:30PM
Recognition of Scholarship Awardees
Room: Mountain/Lake

Speaker 3 of 3
Opeyemi Stella Ademowo, University of Cambridge, UK
Phospholipid Oxidation and Carotenoid Supplementation in Alzheimer’s Disease Patients

Tuesday, February 28 | 7:30PM - 8:30PM
Dinner
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Tuesday, February 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay


Tuesday, February 28 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Wednesday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, March 01 | 8:00AM - 9:00AM
Keynote Address
Room: Mountain/Lake

Speaker 1 of 2
* Michael J.O. Wakelam, Babraham Institute, UK

Wednesday, March 01 | 8:00AM - 9:00AM
Keynote Address
Room: Mountain/Lake

Speaker 2 of 2
Vytas A. Bankaitis, Texas A&M University, USA
Phosphatidylinositol Transfer Protein-Dependent Golgi Positioning Controls Cell Polarity in Neural Stem Cells and Projection Neurons in Developing Mammalian Forebrain

Wednesday, March 01 | 9:00AM - 11:30AM
Lipid Localization and Implications for Cell Regulation
Room: Mountain/Lake

Speaker 1 of 8
* Junken Aoki, Tohoku University, Japan

Wednesday, March 01 | 9:00AM - 11:30AM
Lipid Localization and Implications for Cell Regulation
Room: Mountain/Lake

Speaker 2 of 8
* Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA

Wednesday, March 01 | 9:00AM - 11:30AM
Lipid Localization and Implications for Cell Regulation
Room: Mountain/Lake

Speaker 3 of 8
Per Haberkant, European Molecular Biology Laboratory, Germany
A Quantitative Map of Cellular Protein-Sphingolipid Complexes and their Lipid-Binding Profile

Wednesday, March 01 | 9:00AM - 11:30AM
Lipid Localization and Implications for Cell Regulation
Room: Mountain/Lake


Coffee Break

Wednesday, March 01 | 9:00AM - 11:30AM
Lipid Localization and Implications for Cell Regulation
Room: Mountain/Lake

Speaker 5 of 8
Erwin London, SUNY Stony Brook, USA
Using Cyclodextrins to Control the Lipid Composition, Lipid Asymmetry, and Membrane Properties of Artificial Vesicles and Living Cells

Wednesday, March 01 | 9:00AM - 11:30AM
Lipid Localization and Implications for Cell Regulation
Room: Mountain/Lake

Speaker 6 of 8
John Katsaras, Oak Ridge National Laboratory, USA
Model Membranes, Bacteria and Lateral Membrane Organization

Wednesday, March 01 | 9:00AM - 11:30AM
Lipid Localization and Implications for Cell Regulation
Room: Mountain/Lake

Speaker 7 of 8
Alexander Kros, Leiden University Medical Center, Netherlands
Short Talk: Quantifying Membrane Compound Exchange Between Live Mammalian Cells

Wednesday, March 01 | 9:00AM - 11:30AM
Lipid Localization and Implications for Cell Regulation
Room: Mountain/Lake

Speaker 8 of 8
Kuniyuki Kano, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
Short Talk: Imaging MS Analysis of Lysophospholipids using AP-MALDI-MS

Wednesday, March 01 | 11:30AM - 5:00PM
On Own for Lunch


Wednesday, March 01 | 11:30AM - 1:00PM
Poster Setup
Room: Bay


Wednesday, March 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Wednesday, March 01 | 3:30PM - 4:30PM
Workshop: LIPID MAPS Tools
Room: Mountain/Lake

Speaker 1 of 1
* Eoin Fahy, University of California, San Diego, USA
The LIPID MAPS Lipidomics Gateway

Wednesday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, March 01 | 5:00PM - 7:00PM
Lipidomics
Room: Mountain/Lake

Speaker 1 of 6
* Friedrich Spener, University of Graz, Austria

Wednesday, March 01 | 5:00PM - 7:00PM
Lipidomics
Room: Mountain/Lake

Speaker 2 of 6
* Valerie B. O'Donnell, Cardiff University, UK

Wednesday, March 01 | 5:00PM - 7:00PM
Lipidomics
Room: Mountain/Lake

Speaker 3 of 6
Walter Allen Shaw, Avanti Polar Lipids, Inc., USA
When Bad Things Happen to Good Samples: The Good, the Bad, and the Scary of Lipid Mass Spectrometry

Wednesday, March 01 | 5:00PM - 7:00PM
Lipidomics
Room: Mountain/Lake

Speaker 4 of 6
Kim Ekroos, Lipidomics Consulting Ltd., Finland
High-Definition FLUX Lipidomics

Wednesday, March 01 | 5:00PM - 7:00PM
Lipidomics
Room: Mountain/Lake

Speaker 5 of 6
Toyoshi Fujimoto, Nagoya University Graduate School of Medicine, Japan
Freeze-fracture Electron Microscopy to Define Distribution of Lipids and Lipid Domains at the Nanoscale

Wednesday, March 01 | 5:00PM - 7:00PM
Lipidomics
Room: Mountain/Lake

Speaker 6 of 6
Roger Sandhoff, German Cancer Research Center, Germany
Short Talk: Stereoisomer-Specific Quantification of Simple Bioactive Glycosphingolipids from Bacteria and Mammals

Wednesday, March 01 | 7:00PM - 8:00PM
Dinner
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Wednesday, March 01 | 7:30PM - 10:00PM
Poster Session 3
Room: Bay


Wednesday, March 01 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Thursday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, March 02 | 8:00AM - 11:00AM
Neurological Lipidomics
Room: Mountain/Lake

Speaker 1 of 8
* Tony Futerman, Weizmann Institute of Science, Israel

Thursday, March 02 | 8:00AM - 11:00AM
Neurological Lipidomics
Room: Mountain/Lake

Speaker 2 of 8
* William Griffiths, Swansea University, UK

Thursday, March 02 | 8:00AM - 11:00AM
Neurological Lipidomics
Room: Mountain/Lake

Speaker 3 of 8
Robert C. Murphy, University of Colorado Denver, USA
High-Throughput Lipidomic Analysis the CTS Method:
Application to Neuronal Tissue


Thursday, March 02 | 8:00AM - 11:00AM
Neurological Lipidomics
Room: Mountain/Lake

Speaker 4 of 8
Maria Fuller, SA Pathology, University of Adelaide, Australia
The Brain Lipidome: A Therapeutic Target for Neurodegenerative Disorders

Thursday, March 02 | 8:00AM - 11:00AM
Neurological Lipidomics
Room: Mountain/Lake


Coffee Break

Thursday, March 02 | 8:00AM - 11:00AM
Neurological Lipidomics
Room: Mountain/Lake

Speaker 6 of 8
Steffany A.L. Bennett, University of Ottawa, Canada
Translational Lipidomics: Can Patients with DLB, AD or MCI be Stratified by Interrogating their Plasma Lipidomes?

Thursday, March 02 | 8:00AM - 11:00AM
Neurological Lipidomics
Room: Mountain/Lake

Speaker 7 of 8
Janet E. Deane, University of Cambridge, UK
Short Talk: Aberrant Glycosphingolipid Processing in a Lysosomal Storage Disease

Thursday, March 02 | 8:00AM - 11:00AM
Neurological Lipidomics
Room: Mountain/Lake

Speaker 8 of 8
Patricia C. Kane, NeuroLipid Research Foundation, USA
Short Talk: Addressing Neurological Disorders by Clearing Epigenetics and Stabilizing Membranes and Cardiolipin with Bioactive Lipids

Thursday, March 02 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, March 02 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Thursday, March 02 | 5:00PM - 6:45PM
Metabolism
Room: Mountain/Lake

Speaker 1 of 5
* Dennis R. Voelker, National Jewish Health, USA

Thursday, March 02 | 5:00PM - 6:45PM
Metabolism
Room: Mountain/Lake

Speaker 2 of 5
* L. Ashley Cowart, Virginia Commonwealth University, USA

Thursday, March 02 | 5:00PM - 6:45PM
Metabolism
Room: Mountain/Lake

Speaker 3 of 5
Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Acyl-CoA Metabolism and Partitioning



Thursday, March 02 | 5:00PM - 6:45PM
Metabolism
Room: Mountain/Lake

Speaker 4 of 5
James Mukasa Ntambi, University of Wisconsin-Madison, USA
Regulation of Adipose Tissue Lipogenesis and Fatty Acid Oxidation

Thursday, March 02 | 5:00PM - 6:45PM
Metabolism
Room: Mountain/Lake

Speaker 5 of 5
Nicholas O. Davidson, Washington University School of Medicine, USA
Fatty Acid Flux and Hepatic Fibrosis: Pathways Linking Lipid Metabolism and Liver Injury

Thursday, March 02 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Mountain/Lake


Thursday, March 02 | 7:00PM - 8:00PM
Dinner
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Thursday, March 02 | 7:00PM - 8:00PM
Social Hour
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Thursday, March 02 | 8:00PM - 11:00PM
Entertainment
Room: Granhall
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 02 | 8:00PM - 11:00PM
Cash Bar
Room: Granhall


Friday, March 03 | 10:25AM - 10:25AM
Departure


*Session Chair.