Web Desc
Kinases: Next-Generation Insights and Approaches
Organizer(s): Reid M. Huber, John Kuriyan and Ruth H. Palmer
Date: March 05 - 09, 2017
Location: Beaver Run Resort, Breckenridge, CO, USA
Sponsored by Genentech, Inc. and Incyte Corporation
Summary of Meeting:
Decades of both basic and applied research have unequivocally established the importance of the kinase family of phosphotransferase enzymes in virtually every aspect of organismal homeostasis. From the initial characterization of ATP-dependent phosphorylation in the liver by Gene Kennedy in 1954, our understanding of the family has grown from the diverse perspectives of enzymology, biochemistry, biophysics, structural biology, genetics, cellular biology, pharmacology and physiology. Importantly, these advancements have yielded transformative therapeutic approaches to disease, most notably in the field of cancer where kinase inhibition is helping to fulfill the promise of precision medicine. Yet even today, our perspectives on the complexity of this class of enzymes continues to evolve, and many of the most exciting advancements in the field are being made by applying modern-day insights and technological approaches to the diverse roles the enzymes can play in health and human disease. This meeting is devoted to exploring this innovative leading edge of kinase research, and will bring together leading researchers from academic, clinical and pharmaceutical settings to explore and define the new horizons in the field of kinase biology.
Scholarship Deadline: November 3 2016
Discounted Abstract Deadline: November 3 2016
Abstract Deadline: December 7 2016
Discounted Registration Deadline: January 11 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Genentech, Inc.Incyte Corporation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Blueprint Medicines

Incyte Corporation

Loxo Oncology

Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA216983-01
Funding for this conference was made possible (in part) by 1R13CA216983-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 05 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Sunday, March 05 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Monday, March 06 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Peaks 4-5

Speaker 1 of 4
* Reid M. Huber, MOMA Ventures, USA

Monday, March 06 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Peaks 4-5

Speaker 2 of 4
* John Kuriyan, University of California, Berkeley, USA

Monday, March 06 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Peaks 4-5

Speaker 3 of 4
* Ruth H. Palmer, University of Gothenburg, Sweden

Monday, March 06 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Peaks 4-5

Speaker 4 of 4
Richard M. Marais, Cancer Research UK Manchester Institute, UK
How Far Are We from Implementing Precision Medicine in Melanoma?

Monday, March 06 | 9:00AM - 11:15AM
Pathways of Kinase Function
Room: Peaks 4-5

Speaker 1 of 6
* René H. Medema, Netherlands Cancer Institute, Netherlands

Monday, March 06 | 9:00AM - 11:15AM
Pathways of Kinase Function
Room: Peaks 4-5

Speaker 2 of 6
Tony Hunter, The Salk Institute for Biological Sciences, USA
pHisphorylation in Cell Signaling

Monday, March 06 | 9:00AM - 11:15AM
Pathways of Kinase Function
Room: Peaks 4-5


Coffee Break

Monday, March 06 | 9:00AM - 11:15AM
Pathways of Kinase Function
Room: Peaks 4-5

Speaker 4 of 6
Susan S. Taylor, University of California, San Diego, USA
Lessons Learned from PKA: from Motifs to the Dynamic Assembly of Isoform-specific Macromolecular Switches

Monday, March 06 | 9:00AM - 11:15AM
Pathways of Kinase Function
Room: Peaks 4-5

Speaker 5 of 6
Ruth H. Palmer, University of Gothenburg, Sweden
Regulation of Anaplastic Lymphoma Kinase Signaling during Development and in Neuroblastoma

Monday, March 06 | 9:00AM - 11:15AM
Pathways of Kinase Function
Room: Peaks 4-5

Speaker 6 of 6
Kazuki Hattori, University of Tokyo, Japan
Short Talk: ASK1 Signaling Regulates Brown Adipocyte Maturation

Monday, March 06 | 11:15AM - 5:00PM
On Own for Lunch


Monday, March 06 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Monday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Monday, March 06 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, March 06 | 5:00PM - 7:00PM
Kinases In Cancer Development and Progression
Room: Peaks 4-5

Speaker 1 of 6
* Ruth H. Palmer, University of Gothenburg, Sweden

Monday, March 06 | 5:00PM - 7:00PM
Kinases In Cancer Development and Progression
Room: Peaks 4-5

Speaker 2 of 6
Charles A C Williams, University of Dundee, UK
Short Talk: Erk5 is a Key Regulator of ES Cell Pluripotency: Identification of Klf2 as a Novel Erk5 Substrate

Monday, March 06 | 5:00PM - 7:00PM
Kinases In Cancer Development and Progression
Room: Peaks 4-5

Speaker 3 of 6
René H. Medema, Netherlands Cancer Institute, Netherlands
Mitotic Checkpoint Kinases in Cancer Development and Treatment

Monday, March 06 | 5:00PM - 7:00PM
Kinases In Cancer Development and Progression
Room: Peaks 4-5

Speaker 4 of 6
Nicolas Tapon, Francis Crick Institute, UK
Hippo Kinase Pathway in Tissue Growth Regulation

Monday, March 06 | 5:00PM - 7:00PM
Kinases In Cancer Development and Progression
Room: Peaks 4-5

Speaker 5 of 6
Roger J. Daly, Monash University, Australia
Short Talk: Homo- and Heterotypic Association Regulates Signalling by the SgK269/PEAK1 and SgK223 Pseudokinases

Monday, March 06 | 5:00PM - 7:00PM
Kinases In Cancer Development and Progression
Room: Peaks 4-5

Speaker 6 of 6
Oliver Hantschel, Swiss Federal Institute of Technology Lausanne, Switzerland
Short Talk: Differential Signaling Networks of Bcr-Abl p210 and p190 Kinases in Leukemia Cells Defined by Functional Proteomics

Monday, March 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3
No registration fees are used to fund alcohol served at this function.

Monday, March 06 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 1-3


Tuesday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Tuesday, March 07 | 8:00AM - 11:00AM
Franchise Targets in Drug Discovery
Room: Peaks 4-5

Speaker 1 of 7
* Dorothee Kern, Brandeis University, HHMI, USA

Tuesday, March 07 | 8:00AM - 11:00AM
Franchise Targets in Drug Discovery
Room: Peaks 4-5

Speaker 2 of 7
Reid M. Huber, MOMA Ventures, USA
Janus Activated Kinases – Past, Present and Future

Tuesday, March 07 | 8:00AM - 11:00AM
Franchise Targets in Drug Discovery
Room: Peaks 4-5

Speaker 3 of 7
Andrew Wylie, KSQ Therapeutics, USA
Targeting an Old Dog with New Tricks – BCR-ABL1 and ABL001

Tuesday, March 07 | 8:00AM - 11:00AM
Franchise Targets in Drug Discovery
Room: Peaks 4-5


Coffee Break

Tuesday, March 07 | 8:00AM - 11:00AM
Franchise Targets in Drug Discovery
Room: Peaks 4-5

Speaker 5 of 7
Pasi A. Jänne, Harvard Medical School, USA
EGFR – Third-Generation Approaches to Drug Discovery

Tuesday, March 07 | 8:00AM - 11:00AM
Franchise Targets in Drug Discovery
Room: Peaks 4-5

Speaker 6 of 7
Shiva Malek, Genentech, Inc., USA
Kinases as Molecular Switches: Catalytic and Non-Catalytic Functions of RAF Reveal Novel Insights into Oncogenic Activation

Tuesday, March 07 | 8:00AM - 11:00AM
Franchise Targets in Drug Discovery
Room: Peaks 4-5

Speaker 7 of 7
Tamer Ahmed, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Mechanism-Based Strategies to Overcome Intrinsic and Acquired RAF Inhibitor Resistance in BRAF-Mutant Tumors

Tuesday, March 07 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, March 07 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Tuesday, March 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Tuesday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, March 07 | 5:00PM - 7:00PM
Emerging Pathways in Kinase Inhibitor Discovery
Room: Peaks 4-5

Speaker 1 of 5
* Christoph Lengauer, Third Rock Ventures, USA

Tuesday, March 07 | 5:00PM - 7:00PM
Emerging Pathways in Kinase Inhibitor Discovery
Room: Peaks 4-5

Speaker 2 of 5
Giordano M. Caponigro, Novartis Institutes for BioMedical Research, USA
CDK4/6

Tuesday, March 07 | 5:00PM - 7:00PM
Emerging Pathways in Kinase Inhibitor Discovery
Room: Peaks 4-5

Speaker 3 of 5
Michael Rothenberg, Loxo Oncology, USA
Developing Inhibitors Against Uncommon Oncogenic Kinases

Tuesday, March 07 | 5:00PM - 7:00PM
Emerging Pathways in Kinase Inhibitor Discovery
Room: Peaks 4-5

Speaker 4 of 5
Shohei Koide, New York University Langone Health, USA
Developing Novel Inhibition Strategies using Monobodies

Tuesday, March 07 | 5:00PM - 7:00PM
Emerging Pathways in Kinase Inhibitor Discovery
Room: Peaks 4-5

Speaker 5 of 5
Vitaliy V. Bondar, Baylor College of Medicine, USA
Short Talk: p21-Activated Kinases Modulate ATXN1 Levels Providing Potential Therapeutic Entry Point for Spinocerebellar Ataxia Type 1

Tuesday, March 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3
No registration fees are used to fund alcohol served at this function.

Tuesday, March 07 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 1-3


Wednesday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Wednesday, March 08 | 8:00AM - 11:00AM
Next-Generation Approaches to Kinase Inhibition
Room: Peaks 4-5

Speaker 1 of 7
* Reid M. Huber, MOMA Ventures, USA

Wednesday, March 08 | 8:00AM - 11:00AM
Next-Generation Approaches to Kinase Inhibition
Room: Peaks 4-5

Speaker 2 of 7
Christoph Lengauer, Third Rock Ventures, USA
Crafting Highly Selective Kinase Inhibitors - From Impossible to the Clinic

Wednesday, March 08 | 8:00AM - 11:00AM
Next-Generation Approaches to Kinase Inhibition
Room: Peaks 4-5

Speaker 3 of 7
Dorothee Kern, Brandeis University, HHMI, USA
Ancient Origins of Allosteric Activation in Kinases – Exploitation for Novel Cancer Drugs

Wednesday, March 08 | 8:00AM - 11:00AM
Next-Generation Approaches to Kinase Inhibition
Room: Peaks 4-5


Coffee Break

Wednesday, March 08 | 8:00AM - 11:00AM
Next-Generation Approaches to Kinase Inhibition
Room: Peaks 4-5

Speaker 5 of 7
Soumya S. Ray, Schrödinger, USA
Short Talk: Role of Active Site Water Molecules in Designing Potent Selective Kinase Inhibitors

Wednesday, March 08 | 8:00AM - 11:00AM
Next-Generation Approaches to Kinase Inhibition
Room: Peaks 4-5

Speaker 6 of 7
David E. Puleo, Yale University, USA
Short Talk: Identification and Characterization of Small Molecule Binders of the JAK2 Pseudokinase Domain

Wednesday, March 08 | 8:00AM - 11:00AM
Next-Generation Approaches to Kinase Inhibition
Room: Peaks 4-5

Speaker 7 of 7
Johanna Elisabeth Mayrhofer, University of Innsbruck, Austria
Short Talk: Recording of RAF Kinase:Drug Interactions in vivo

Wednesday, March 08 | 11:00AM - 2:30PM
On Own for Lunch


Wednesday, March 08 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Wednesday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Wednesday, March 08 | 2:30PM - 4:30PM
Workshop: Emerging Methodological Approaches to Kinase Resea
rch
Room: Peaks 4-5

Speaker 1 of 8
* Shiva Malek, Genentech, Inc., USA

Wednesday, March 08 | 2:30PM - 4:30PM
Workshop: Emerging Methodological Approaches to Kinase Resea
rch
Room: Peaks 4-5

Speaker 2 of 8
Tarjani M. Thaker, University of California, San Francisco, USA
Defining the HER2 Interactome by Proximity-Based Extracellular Tagging

Wednesday, March 08 | 2:30PM - 4:30PM
Workshop: Emerging Methodological Approaches to Kinase Resea
rch
Room: Peaks 4-5

Speaker 3 of 8
Katelyn B. Connell, Biodesy, USA
A High-Throughput Method for Inhibitor-Induced Conformational Changes in kinases

Wednesday, March 08 | 2:30PM - 4:30PM
Workshop: Emerging Methodological Approaches to Kinase Resea
rch
Room: Peaks 4-5

Speaker 4 of 8
Rodrigo Maillard, Georgetown University, USA
Investigating the Conformational Landscape of Protein Kinase A with Optical Tweezers

Wednesday, March 08 | 2:30PM - 4:30PM
Workshop: Emerging Methodological Approaches to Kinase Resea
rch
Room: Peaks 4-5

Speaker 5 of 8
Khalil A. Davis, Francis Crick Institute, UK
Genetically Encoded Photocrosslinking Amino Acids for In-Cell Kinase Substrate Identification

Wednesday, March 08 | 2:30PM - 4:30PM
Workshop: Emerging Methodological Approaches to Kinase Resea
rch
Room: Peaks 4-5

Speaker 6 of 8
Joshua M. Lubner, USA
Using Bacteria to Characterize and Engineer Protein Kinase Specificity

Wednesday, March 08 | 2:30PM - 4:30PM
Workshop: Emerging Methodological Approaches to Kinase Resea
rch
Room: Peaks 4-5

Speaker 7 of 8
Michael Z. Lin, Stanford University School of Medicine, USA
Quantitative Control of Cell Signaling by Single-Chain Photoswitchable Kinases

Wednesday, March 08 | 2:30PM - 4:30PM
Workshop: Emerging Methodological Approaches to Kinase Resea
rch
Room: Peaks 4-5

Speaker 8 of 8
Matthew Robers, Promega Corporation, USA
Kinome-Wide Profiling of Target Engagement and Residence Time in Living Cells Using NanoBRET

Wednesday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 08 | 5:00PM - 7:00PM
Kinase Inhibitor Resistance
Room: Peaks 4-5

Speaker 1 of 5
* Natalia Jura, University of California, San Francisco, USA

Wednesday, March 08 | 5:00PM - 7:00PM
Kinase Inhibitor Resistance
Room: Peaks 4-5

Speaker 2 of 5
Rani E. George, Dana-Farber Cancer Institute, USA
Differential Mechanisms of ALK Inhibitor Resistance

Wednesday, March 08 | 5:00PM - 7:00PM
Kinase Inhibitor Resistance
Room: Peaks 4-5

Speaker 3 of 5
Matthew A. Smith, Moffitt Cancer Center, USA
Using Proximity Ligation Assays to Interrogate RTK Activity in Cancers

Wednesday, March 08 | 5:00PM - 7:00PM
Kinase Inhibitor Resistance
Room: Peaks 4-5

Speaker 4 of 5
Ethan Ahler, University of Washington, USA
Short Talk: High-Throughput Mutagenesis Reveals Novel Mechanisms of Drug Resistance in the Oncogene Src Kinase

Wednesday, March 08 | 5:00PM - 7:00PM
Kinase Inhibitor Resistance
Room: Peaks 4-5

Speaker 5 of 5
James Duncan, Fox Chase Cancer Center, USA
Short Talk: Exploring the 'Dark' Kinome Using Chemical Proteomics

Wednesday, March 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3
No registration fees are used to fund alcohol served at this function.

Wednesday, March 08 | 7:30PM - 10:00PM
Poster Session 3
Room: Peaks 1-3


Thursday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Thursday, March 09 | 8:00AM - 11:15AM
Kinase Signaling and Subcellular Context
Room: Peaks 4-5

Speaker 1 of 8
* Susan S. Taylor, University of California, San Diego, USA

Thursday, March 09 | 8:00AM - 11:15AM
Kinase Signaling and Subcellular Context
Room: Peaks 4-5

Speaker 2 of 8
John Kuriyan, University of California, Berkeley, USA
Specificity in Kinase Pathways Downstream of the T Cell Receptor

Thursday, March 09 | 8:00AM - 11:15AM
Kinase Signaling and Subcellular Context
Room: Peaks 4-5

Speaker 3 of 8
John D. Scott, University of Washington, USA
Guiding Signals through Anchored Enzyme Complexes

Thursday, March 09 | 8:00AM - 11:15AM
Kinase Signaling and Subcellular Context
Room: Peaks 4-5


Coffee Break

Thursday, March 09 | 8:00AM - 11:15AM
Kinase Signaling and Subcellular Context
Room: Peaks 4-5

Speaker 5 of 8
Natalia Jura, University of California, San Francisco, USA
New Insights into Control of HER3 Receptor Pseudokinase Signaling

Thursday, March 09 | 8:00AM - 11:15AM
Kinase Signaling and Subcellular Context
Room: Peaks 4-5

Speaker 6 of 8
Benjamin E. Turk, Yale University, USA
Deciphering Mechanisms of Protein Kinase Substrate Targeting

Thursday, March 09 | 8:00AM - 11:15AM
Kinase Signaling and Subcellular Context
Room: Peaks 4-5

Speaker 7 of 8
Chris Phillips, AstraZeneca, UK
Short Talk: Mechanistic Insights into ATM Activation from Cryo-Electron Microscopy: Open and Closed Dimers

Thursday, March 09 | 8:00AM - 11:15AM
Kinase Signaling and Subcellular Context
Room: Peaks 4-5

Speaker 8 of 8
Andrei V. Karginov, University of Illinois at Chicago, USA
Short Talk: Mimicking Transient Activation of Protein Kinases in Living Cells

Thursday, March 09 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, March 09 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, March 09 | 5:00PM - 6:45PM
Systems and Synthetic Biology of Kinases
Room: Peaks 4-5

Speaker 1 of 5
* John Kuriyan, University of California, Berkeley, USA

Thursday, March 09 | 5:00PM - 6:45PM
Systems and Synthetic Biology of Kinases
Room: Peaks 4-5

Speaker 2 of 5
Forest M. White, Massachusetts Institute of Technology, USA
High Temporal Resolution Analysis of Phosphorylation Mediated Signaling Networks

Thursday, March 09 | 5:00PM - 6:45PM
Systems and Synthetic Biology of Kinases
Room: Peaks 4-5

Speaker 3 of 5
James E. Ferrell Jr., Stanford University, USA
A Second Bistable Switch in Mitosis

Thursday, March 09 | 5:00PM - 6:45PM
Systems and Synthetic Biology of Kinases
Room: Peaks 4-5

Speaker 4 of 5
Emily F. Ruff, University of Minnesota, USA
Short Talk: Novel Allosteric FRET Assays for Mechanistic Studies and Inhibitor Screening of Aurora A Kinase

Thursday, March 09 | 5:00PM - 6:45PM
Systems and Synthetic Biology of Kinases
Room: Peaks 4-5

Speaker 5 of 5
Zhong Yao, University of Toronto, Canada
Short Talk: A Global Analysis of The Receptor Tyrosine Kinase - Protein Phosphatase Interactome

Thursday, March 09 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Peaks 4-5


Thursday, March 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3
No registration fees are used to fund alcohol served at this function.

Thursday, March 09 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 1-3
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 09 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 1-3


Friday, March 10 | 10:25AM - 10:25AM
Departure


*Session Chair.