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Web Desc
Kinases: Next-Generation Insights and Approaches Organizer(s): Reid M. Huber, John Kuriyan and Ruth H. Palmer Date: March 05 - 09, 2017 Location: Beaver Run Resort, Breckenridge, CO, USA Sponsored by Genentech, Inc. and Incyte Corporation Summary of Meeting: Decades of both basic and applied research have unequivocally established the importance of the kinase family of phosphotransferase enzymes in virtually every aspect of organismal homeostasis. From the initial characterization of ATP-dependent phosphorylation in the liver by Gene Kennedy in 1954, our understanding of the family has grown from the diverse perspectives of enzymology, biochemistry, biophysics, structural biology, genetics, cellular biology, pharmacology and physiology. Importantly, these advancements have yielded transformative therapeutic approaches to disease, most notably in the field of cancer where kinase inhibition is helping to fulfill the promise of precision medicine. Yet even today, our perspectives on the complexity of this class of enzymes continues to evolve, and many of the most exciting advancements in the field are being made by applying modern-day insights and technological approaches to the diverse roles the enzymes can play in health and human disease. This meeting is devoted to exploring this innovative leading edge of kinase research, and will bring together leading researchers from academic, clinical and pharmaceutical settings to explore and define the new horizons in the field of kinase biology. Scholarship Deadline: November 3 2016 Discounted Abstract Deadline: November 3 2016 Abstract Deadline: December 7 2016 Discounted Registration Deadline: January 11 2017 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Blueprint Medicines Incyte Corporation Loxo Oncology Novartis Institutes for BioMedical Research We gratefully acknowledge the generous grant for this conference provided by: National Cancer Institute (NCI) Grant No. 1R13CA216983-01 Funding for this conference was made possible (in part) by 1R13CA216983-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Kinases: Next-Generation Insights and Approaches

Organizer(s): Reid M. Huber, John Kuriyan and Ruth H. Palmer

Date: March 05 - 09, 2017
Location: Beaver Run Resort, Breckenridge, CO, USA

Sponsored by Genentech, Inc. and Incyte Corporation

Summary of Meeting:

Decades of both basic and applied research have unequivocally established the importance of the kinase family of phosphotransferase enzymes in virtually every aspect of organismal homeostasis. From the initial characterization of ATP-dependent phosphorylation in the liver by Gene Kennedy in 1954, our understanding of the family has grown from the diverse perspectives of enzymology, biochemistry, biophysics, structural biology, genetics, cellular biology, pharmacology and physiology. Importantly, these advancements have yielded transformative therapeutic approaches to disease, most notably in the field of cancer where kinase inhibition is helping to fulfill the promise of precision medicine. Yet even today, our perspectives on the complexity of this class of enzymes continues to evolve, and many of the most exciting advancements in the field are being made by applying modern-day insights and technological approaches to the diverse roles the enzymes can play in health and human disease. This meeting is devoted to exploring this innovative leading edge of kinase research, and will bring together leading researchers from academic, clinical and pharmaceutical settings to explore and define the new horizons in the field of kinase biology.

Scholarship Deadline: November 3 2016

Discounted Abstract Deadline: November 3 2016

Abstract Deadline: December 7 2016

Discounted Registration Deadline: January 11 2017

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Blueprint Medicines

Incyte Corporation

Loxo Oncology

Novartis Institutes for BioMedical Research

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA216983-01
Funding for this conference was made possible (in part) by 1R13CA216983-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 05 \| 4:00PM - 8:00PM Arrival and Registration Room: Foyer
Sunday, March 05 \| 6:00PM - 8:00PM Welcome Mixer Room: Foyer No registration fees are used to fund alcohol served at this function.
Monday, March 06 \| 7:00AM - 8:00AM Breakfast Room: Summit Gallery
Monday, March 06 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Peaks 4-5 Speaker 1 of 4 * Reid M. Huber, MOMA Ventures, USA
Monday, March 06 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Peaks 4-5 Speaker 2 of 4 * John Kuriyan, University of California, Berkeley, USA
Monday, March 06 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Peaks 4-5 Speaker 3 of 4 * Ruth H. Palmer, University of Gothenburg, Sweden
Monday, March 06 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Peaks 4-5 Speaker 4 of 4 Richard M. Marais, Cancer Research UK Manchester Institute, UK How Far Are We from Implementing Precision Medicine in Melanoma?
Monday, March 06 \| 9:00AM - 11:15AM Pathways of Kinase Function Room: Peaks 4-5 Speaker 1 of 6 * René H. Medema, Netherlands Cancer Institute, Netherlands
Monday, March 06 \| 9:00AM - 11:15AM Pathways of Kinase Function Room: Peaks 4-5 Speaker 2 of 6 Tony Hunter, The Salk Institute for Biological Sciences, USA pHisphorylation in Cell Signaling
Monday, March 06 \| 9:00AM - 11:15AM Pathways of Kinase Function Room: Peaks 4-5 Coffee Break
Monday, March 06 \| 9:00AM - 11:15AM Pathways of Kinase Function Room: Peaks 4-5 Speaker 4 of 6 Susan S. Taylor, University of California, San Diego, USA Lessons Learned from PKA: from Motifs to the Dynamic Assembly of Isoform-specific Macromolecular Switches
Monday, March 06 \| 9:00AM - 11:15AM Pathways of Kinase Function Room: Peaks 4-5 Speaker 5 of 6 Ruth H. Palmer, University of Gothenburg, Sweden Regulation of Anaplastic Lymphoma Kinase Signaling during Development and in Neuroblastoma
Monday, March 06 \| 9:00AM - 11:15AM Pathways of Kinase Function Room: Peaks 4-5 Speaker 6 of 6 Kazuki Hattori, University of Tokyo, Japan Short Talk: ASK1 Signaling Regulates Brown Adipocyte Maturation
Monday, March 06 \| 11:15AM - 5:00PM On Own for Lunch
Monday, March 06 \| 11:15AM - 1:00PM Poster Setup Room: Peaks 1-3
Monday, March 06 \| 1:00PM - 10:00PM Poster Viewing Room: Peaks 1-3
Monday, March 06 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Monday, March 06 \| 5:00PM - 7:00PM Kinases In Cancer Development and Progression Room: Peaks 4-5 Speaker 1 of 6 * Ruth H. Palmer, University of Gothenburg, Sweden
Monday, March 06 \| 5:00PM - 7:00PM Kinases In Cancer Development and Progression Room: Peaks 4-5 Speaker 2 of 6 Charles A C Williams, University of Dundee, UK Short Talk: Erk5 is a Key Regulator of ES Cell Pluripotency: Identification of Klf2 as a Novel Erk5 Substrate
Monday, March 06 \| 5:00PM - 7:00PM Kinases In Cancer Development and Progression Room: Peaks 4-5 Speaker 3 of 6 René H. Medema, Netherlands Cancer Institute, Netherlands Mitotic Checkpoint Kinases in Cancer Development and Treatment
Monday, March 06 \| 5:00PM - 7:00PM Kinases In Cancer Development and Progression Room: Peaks 4-5 Speaker 4 of 6 Nicolas Tapon, Francis Crick Institute, UK Hippo Kinase Pathway in Tissue Growth Regulation
Monday, March 06 \| 5:00PM - 7:00PM Kinases In Cancer Development and Progression Room: Peaks 4-5 Speaker 5 of 6 Roger J. Daly, Monash University, Australia Short Talk: Homo- and Heterotypic Association Regulates Signalling by the SgK269/PEAK1 and SgK223 Pseudokinases
Monday, March 06 \| 5:00PM - 7:00PM Kinases In Cancer Development and Progression Room: Peaks 4-5 Speaker 6 of 6 Oliver Hantschel, Swiss Federal Institute of Technology Lausanne, Switzerland Short Talk: Differential Signaling Networks of Bcr-Abl p210 and p190 Kinases in Leukemia Cells Defined by Functional Proteomics
Monday, March 06 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Peaks 1-3 No registration fees are used to fund alcohol served at this function.
Monday, March 06 \| 7:30PM - 10:00PM Poster Session 1 Room: Peaks 1-3
Tuesday, March 07 \| 7:00AM - 8:00AM Breakfast Room: Summit Gallery
Tuesday, March 07 \| 8:00AM - 11:00AM Franchise Targets in Drug Discovery Room: Peaks 4-5 Speaker 1 of 7 * Dorothee Kern, Brandeis University, HHMI, USA
Tuesday, March 07 \| 8:00AM - 11:00AM Franchise Targets in Drug Discovery Room: Peaks 4-5 Speaker 2 of 7 Reid M. Huber, MOMA Ventures, USA Janus Activated Kinases – Past, Present and Future
Tuesday, March 07 \| 8:00AM - 11:00AM Franchise Targets in Drug Discovery Room: Peaks 4-5 Speaker 3 of 7 Andrew Wylie, KSQ Therapeutics, USA Targeting an Old Dog with New Tricks – BCR-ABL1 and ABL001
Tuesday, March 07 \| 8:00AM - 11:00AM Franchise Targets in Drug Discovery Room: Peaks 4-5 Coffee Break
Tuesday, March 07 \| 8:00AM - 11:00AM Franchise Targets in Drug Discovery Room: Peaks 4-5 Speaker 5 of 7 Pasi A. Jänne, Harvard Medical School, USA EGFR – Third-Generation Approaches to Drug Discovery
Tuesday, March 07 \| 8:00AM - 11:00AM Franchise Targets in Drug Discovery Room: Peaks 4-5 Speaker 6 of 7 Shiva Malek, Genentech, Inc., USA Kinases as Molecular Switches: Catalytic and Non-Catalytic Functions of RAF Reveal Novel Insights into Oncogenic Activation
Tuesday, March 07 \| 8:00AM - 11:00AM Franchise Targets in Drug Discovery Room: Peaks 4-5 Speaker 7 of 7 Tamer Ahmed, Icahn School of Medicine at Mount Sinai, USA Short Talk: Mechanism-Based Strategies to Overcome Intrinsic and Acquired RAF Inhibitor Resistance in BRAF-Mutant Tumors
Tuesday, March 07 \| 11:00AM - 5:00PM On Own for Lunch
Tuesday, March 07 \| 11:00AM - 1:00PM Poster Setup Room: Peaks 1-3
Tuesday, March 07 \| 1:00PM - 10:00PM Poster Viewing Room: Peaks 1-3
Tuesday, March 07 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Tuesday, March 07 \| 5:00PM - 7:00PM Emerging Pathways in Kinase Inhibitor Discovery Room: Peaks 4-5 Speaker 1 of 5 * Christoph Lengauer, Third Rock Ventures, USA
Tuesday, March 07 \| 5:00PM - 7:00PM Emerging Pathways in Kinase Inhibitor Discovery Room: Peaks 4-5 Speaker 2 of 5 Giordano M. Caponigro, Novartis Institutes for BioMedical Research, USA CDK4/6
Tuesday, March 07 \| 5:00PM - 7:00PM Emerging Pathways in Kinase Inhibitor Discovery Room: Peaks 4-5 Speaker 3 of 5 Michael Rothenberg, Loxo Oncology, USA Developing Inhibitors Against Uncommon Oncogenic Kinases
Tuesday, March 07 \| 5:00PM - 7:00PM Emerging Pathways in Kinase Inhibitor Discovery Room: Peaks 4-5 Speaker 4 of 5 Shohei Koide, New York University Langone Health, USA Developing Novel Inhibition Strategies using Monobodies
Tuesday, March 07 \| 5:00PM - 7:00PM Emerging Pathways in Kinase Inhibitor Discovery Room: Peaks 4-5 Speaker 5 of 5 Vitaliy V. Bondar, Baylor College of Medicine, USA Short Talk: p21-Activated Kinases Modulate ATXN1 Levels Providing Potential Therapeutic Entry Point for Spinocerebellar Ataxia Type 1
Tuesday, March 07 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Peaks 1-3 No registration fees are used to fund alcohol served at this function.
Tuesday, March 07 \| 7:30PM - 10:00PM Poster Session 2 Room: Peaks 1-3
Wednesday, March 08 \| 7:00AM - 8:00AM Breakfast Room: Summit Gallery
Wednesday, March 08 \| 8:00AM - 11:00AM Next-Generation Approaches to Kinase Inhibition Room: Peaks 4-5 Speaker 1 of 7 * Reid M. Huber, MOMA Ventures, USA
Wednesday, March 08 \| 8:00AM - 11:00AM Next-Generation Approaches to Kinase Inhibition Room: Peaks 4-5 Speaker 2 of 7 Christoph Lengauer, Third Rock Ventures, USA Crafting Highly Selective Kinase Inhibitors - From Impossible to the Clinic
Wednesday, March 08 \| 8:00AM - 11:00AM Next-Generation Approaches to Kinase Inhibition Room: Peaks 4-5 Speaker 3 of 7 Dorothee Kern, Brandeis University, HHMI, USA Ancient Origins of Allosteric Activation in Kinases – Exploitation for Novel Cancer Drugs
Wednesday, March 08 \| 8:00AM - 11:00AM Next-Generation Approaches to Kinase Inhibition Room: Peaks 4-5 Coffee Break
Wednesday, March 08 \| 8:00AM - 11:00AM Next-Generation Approaches to Kinase Inhibition Room: Peaks 4-5 Speaker 5 of 7 Soumya S. Ray, Schrödinger, USA Short Talk: Role of Active Site Water Molecules in Designing Potent Selective Kinase Inhibitors
Wednesday, March 08 \| 8:00AM - 11:00AM Next-Generation Approaches to Kinase Inhibition Room: Peaks 4-5 Speaker 6 of 7 David E. Puleo, Yale University, USA Short Talk: Identification and Characterization of Small Molecule Binders of the JAK2 Pseudokinase Domain
Wednesday, March 08 \| 8:00AM - 11:00AM Next-Generation Approaches to Kinase Inhibition Room: Peaks 4-5 Speaker 7 of 7 Johanna Elisabeth Mayrhofer, University of Innsbruck, Austria Short Talk: Recording of RAF Kinase:Drug Interactions in vivo
Wednesday, March 08 \| 11:00AM - 2:30PM On Own for Lunch
Wednesday, March 08 \| 11:00AM - 1:00PM Poster Setup Room: Peaks 1-3
Wednesday, March 08 \| 1:00PM - 10:00PM Poster Viewing Room: Peaks 1-3
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop: Emerging Methodological Approaches to Kinase Resea rch Room: Peaks 4-5 Speaker 1 of 8 * Shiva Malek, Genentech, Inc., USA
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop: Emerging Methodological Approaches to Kinase Resea rch Room: Peaks 4-5 Speaker 2 of 8 Tarjani M. Thaker, University of California, San Francisco, USA Defining the HER2 Interactome by Proximity-Based Extracellular Tagging
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop: Emerging Methodological Approaches to Kinase Resea rch Room: Peaks 4-5 Speaker 3 of 8 Katelyn B. Connell, Biodesy, USA A High-Throughput Method for Inhibitor-Induced Conformational Changes in kinases
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop: Emerging Methodological Approaches to Kinase Resea rch Room: Peaks 4-5 Speaker 4 of 8 Rodrigo Maillard, Georgetown University, USA Investigating the Conformational Landscape of Protein Kinase A with Optical Tweezers
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop: Emerging Methodological Approaches to Kinase Resea rch Room: Peaks 4-5 Speaker 5 of 8 Khalil A. Davis, Francis Crick Institute, UK Genetically Encoded Photocrosslinking Amino Acids for In-Cell Kinase Substrate Identification
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop: Emerging Methodological Approaches to Kinase Resea rch Room: Peaks 4-5 Speaker 6 of 8 Joshua M. Lubner, USA Using Bacteria to Characterize and Engineer Protein Kinase Specificity
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop: Emerging Methodological Approaches to Kinase Resea rch Room: Peaks 4-5 Speaker 7 of 8 Michael Z. Lin, Stanford University School of Medicine, USA Quantitative Control of Cell Signaling by Single-Chain Photoswitchable Kinases
Wednesday, March 08 \| 2:30PM - 4:30PM Workshop: Emerging Methodological Approaches to Kinase Resea rch Room: Peaks 4-5 Speaker 8 of 8 Matthew Robers, Promega Corporation, USA Kinome-Wide Profiling of Target Engagement and Residence Time in Living Cells Using NanoBRET
Wednesday, March 08 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Wednesday, March 08 \| 5:00PM - 7:00PM Kinase Inhibitor Resistance Room: Peaks 4-5 Speaker 1 of 5 * Natalia Jura, University of California, San Francisco, USA
Wednesday, March 08 \| 5:00PM - 7:00PM Kinase Inhibitor Resistance Room: Peaks 4-5 Speaker 2 of 5 Rani E. George, Dana-Farber Cancer Institute, USA Differential Mechanisms of ALK Inhibitor Resistance
Wednesday, March 08 \| 5:00PM - 7:00PM Kinase Inhibitor Resistance Room: Peaks 4-5 Speaker 3 of 5 Matthew A. Smith, Moffitt Cancer Center, USA Using Proximity Ligation Assays to Interrogate RTK Activity in Cancers
Wednesday, March 08 \| 5:00PM - 7:00PM Kinase Inhibitor Resistance Room: Peaks 4-5 Speaker 4 of 5 Ethan Ahler, University of Washington, USA Short Talk: High-Throughput Mutagenesis Reveals Novel Mechanisms of Drug Resistance in the Oncogene Src Kinase
Wednesday, March 08 \| 5:00PM - 7:00PM Kinase Inhibitor Resistance Room: Peaks 4-5 Speaker 5 of 5 James Duncan, Fox Chase Cancer Center, USA Short Talk: Exploring the 'Dark' Kinome Using Chemical Proteomics
Wednesday, March 08 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Peaks 1-3 No registration fees are used to fund alcohol served at this function.
Wednesday, March 08 \| 7:30PM - 10:00PM Poster Session 3 Room: Peaks 1-3
Thursday, March 09 \| 7:00AM - 8:00AM Breakfast Room: Summit Gallery
Thursday, March 09 \| 8:00AM - 11:15AM Kinase Signaling and Subcellular Context Room: Peaks 4-5 Speaker 1 of 8 * Susan S. Taylor, University of California, San Diego, USA
Thursday, March 09 \| 8:00AM - 11:15AM Kinase Signaling and Subcellular Context Room: Peaks 4-5 Speaker 2 of 8 John Kuriyan, University of California, Berkeley, USA Specificity in Kinase Pathways Downstream of the T Cell Receptor
Thursday, March 09 \| 8:00AM - 11:15AM Kinase Signaling and Subcellular Context Room: Peaks 4-5 Speaker 3 of 8 John D. Scott, University of Washington, USA Guiding Signals through Anchored Enzyme Complexes
Thursday, March 09 \| 8:00AM - 11:15AM Kinase Signaling and Subcellular Context Room: Peaks 4-5 Coffee Break
Thursday, March 09 \| 8:00AM - 11:15AM Kinase Signaling and Subcellular Context Room: Peaks 4-5 Speaker 5 of 8 Natalia Jura, University of California, San Francisco, USA New Insights into Control of HER3 Receptor Pseudokinase Signaling
Thursday, March 09 \| 8:00AM - 11:15AM Kinase Signaling and Subcellular Context Room: Peaks 4-5 Speaker 6 of 8 Benjamin E. Turk, Yale University, USA Deciphering Mechanisms of Protein Kinase Substrate Targeting
Thursday, March 09 \| 8:00AM - 11:15AM Kinase Signaling and Subcellular Context Room: Peaks 4-5 Speaker 7 of 8 Chris Phillips, AstraZeneca, UK Short Talk: Mechanistic Insights into ATM Activation from Cryo-Electron Microscopy: Open and Closed Dimers
Thursday, March 09 \| 8:00AM - 11:15AM Kinase Signaling and Subcellular Context Room: Peaks 4-5 Speaker 8 of 8 Andrei V. Karginov, University of Illinois at Chicago, USA Short Talk: Mimicking Transient Activation of Protein Kinases in Living Cells
Thursday, March 09 \| 11:15AM - 5:00PM On Own for Lunch
Thursday, March 09 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Thursday, March 09 \| 5:00PM - 6:45PM Systems and Synthetic Biology of Kinases Room: Peaks 4-5 Speaker 1 of 5 * John Kuriyan, University of California, Berkeley, USA
Thursday, March 09 \| 5:00PM - 6:45PM Systems and Synthetic Biology of Kinases Room: Peaks 4-5 Speaker 2 of 5 Forest M. White, Massachusetts Institute of Technology, USA High Temporal Resolution Analysis of Phosphorylation Mediated Signaling Networks
Thursday, March 09 \| 5:00PM - 6:45PM Systems and Synthetic Biology of Kinases Room: Peaks 4-5 Speaker 3 of 5 James E. Ferrell Jr., Stanford University, USA A Second Bistable Switch in Mitosis
Thursday, March 09 \| 5:00PM - 6:45PM Systems and Synthetic Biology of Kinases Room: Peaks 4-5 Speaker 4 of 5 Emily F. Ruff, University of Minnesota, USA Short Talk: Novel Allosteric FRET Assays for Mechanistic Studies and Inhibitor Screening of Aurora A Kinase
Thursday, March 09 \| 5:00PM - 6:45PM Systems and Synthetic Biology of Kinases Room: Peaks 4-5 Speaker 5 of 5 Zhong Yao, University of Toronto, Canada Short Talk: A Global Analysis of The Receptor Tyrosine Kinase - Protein Phosphatase Interactome
Thursday, March 09 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Peaks 4-5
Thursday, March 09 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Peaks 1-3 No registration fees are used to fund alcohol served at this function.
Thursday, March 09 \| 8:00PM - 11:00PM Entertainment Room: Peaks 1-3 Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, March 09 \| 8:00PM - 11:00PM Cash Bar Room: Peaks 1-3
Friday, March 10 \| 10:25AM - 10:25AM Departure *Session Chair.