Web Desc
Frontiers of NMR in Life Sciences
Organizer(s): Kurt Wüthrich, Michael Sattler and Stephen W. Fesik
Date: March 12 - 16, 2017
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Merck & Co., Inc.
Summary of Meeting:
The NMR principle is widely applied in structural biology, biomedical research and clinical diagnosis. This conference will highlight progress in solution and solid state NMR methods and recent advances in selected NMR applications in metabolic profiling, drug research, protein/ nucleic acid interactions, in-cell NMR, intrinsically disordered proteins and the study of membrane proteins. Attendees will obtain an overview of the principal advances made during the last four years with the use of NMR techniques in structural biology and biomedical research, and receive guidance on anticipated mid-term and long-term future advances with NMR applications in molecular and cell biology.
Scholarship Deadline: November 15 2016
Discounted Abstract Deadline: November 15 2016
Abstract Deadline: December 13 2016
Discounted Registration Deadline: January 13 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Merck & Co., Inc.
We gratefully acknowledge additional support for this conference from:
Bruker BioSpinNew Era Enterprises, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 12 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, March 12 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 13 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Monday, March 13 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 1 of 2
* Kurt Wüthrich, ETH Zürich, Switzerland / The Scripps Research Institute, USA, Switzerland

Monday, March 13 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 2 of 2
Lewis E. Kay, University of Toronto, Canada
NMR: Why Bother?

Monday, March 13 | 9:00AM - 11:15AM
Innovative Solution NMR Methods for Studying Biological Macr
omolecules

Room: Grays Peak

Speaker 1 of 6
* Michael Sattler, Helmholtz Zentrum München & Technische Universität München, Germany

Monday, March 13 | 9:00AM - 11:15AM
Innovative Solution NMR Methods for Studying Biological Macr
omolecules

Room: Grays Peak

Speaker 2 of 6
Dominique P. Frueh, Johns Hopkins University School of Medicine, USA
Invited Short Talk: Overcoming Challenges in NMR Studies of Large and Dynamic Nonribosomal Peptide Synthetases

Monday, March 13 | 9:00AM - 11:15AM
Innovative Solution NMR Methods for Studying Biological Macr
omolecules

Room: Grays Peak

Speaker 3 of 6
Wolfgang Peti, University of Arizona, USA
Invited Short Talk: Using Dynamics and Structure to Understand Allostery in Signaling Enzymes

Monday, March 13 | 9:00AM - 11:15AM
Innovative Solution NMR Methods for Studying Biological Macr
omolecules

Room: Grays Peak


Coffee Break

Monday, March 13 | 9:00AM - 11:15AM
Innovative Solution NMR Methods for Studying Biological Macr
omolecules

Room: Grays Peak

Speaker 5 of 6
Haribabu Arthanari, Harvard Medical School, USA
Invited Short Talk: Increasing Resolution of Backbone Experiments: Thinking Beyond the Nyqvist Grid

Monday, March 13 | 9:00AM - 11:15AM
Innovative Solution NMR Methods for Studying Biological Macr
omolecules

Room: Grays Peak

Speaker 6 of 6
Christian Griesinger, Max Planck Institute for Biophysical Chemistry, Germany
NMR-Based Structural Biology in Immunity and Neurodegeneration/Protectoin

Monday, March 13 | 11:15AM - 5:00PM
On Own for Lunch


Monday, March 13 | 11:15AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Monday, March 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Monday, March 13 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 13 | 5:00PM - 7:00PM
Use of NMR in Metabolic Profiling
Room: Grays Peak

Speaker 1 of 4
* Jane Dyson, The Scripps Research Institute, USA

Monday, March 13 | 5:00PM - 7:00PM
Use of NMR in Metabolic Profiling
Room: Grays Peak

Speaker 2 of 4
Teresa W. M. Fan, University of Kentucky Markey Cancer Center, USA
Metabolic Network Mapping by Stable Isotope Resolved Metabolomics (SIRM)

Monday, March 13 | 5:00PM - 7:00PM
Use of NMR in Metabolic Profiling
Room: Grays Peak

Speaker 3 of 4
Rafael Brüschweiler, Ohio State University, USA
NMR and NMR/MS Hybrid Approaches for Targeted and Untargeted Metabolomics


Monday, March 13 | 5:00PM - 7:00PM
Use of NMR in Metabolic Profiling
Room: Grays Peak

Speaker 4 of 4
Michael A. Kennedy, Miami University, USA
NMR-Based Metabolic Profiling of Human Diseases

Monday, March 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Monday, March 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Tuesday, March 14 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Tuesday, March 14 | 8:00AM - 11:00AM
Protein-Nucleic Acid Interactions
Room: Grays Peak

Speaker 1 of 7
* Robert Kaptein, University of Utrecht, Netherlands

Tuesday, March 14 | 8:00AM - 11:00AM
Protein-Nucleic Acid Interactions
Room: Grays Peak

Speaker 2 of 7
Frédéric H.T. Allain, ETH Zurich, Switzerland
Structures of Protein RNA Complexes using Hybrid Structural Approaches

Tuesday, March 14 | 8:00AM - 11:00AM
Protein-Nucleic Acid Interactions
Room: Grays Peak

Speaker 3 of 7
Hashim M. Al-Hashimi, Duke University, USA
Visualizing Transient Watson-Crick Mispairs in DNA and RNA Duplexes

Tuesday, March 14 | 8:00AM - 11:00AM
Protein-Nucleic Acid Interactions
Room: Grays Peak


Coffee Break

Tuesday, March 14 | 8:00AM - 11:00AM
Protein-Nucleic Acid Interactions
Room: Grays Peak

Speaker 5 of 7
Pedro Serrano-Navarro, The Scripps Research Institute, USA
Invited Short Talk: In vitro Studies of Arginine-Serine-Rich Domains


Tuesday, March 14 | 8:00AM - 11:00AM
Protein-Nucleic Acid Interactions
Room: Grays Peak

Speaker 6 of 7
Teresa Carlomagno, Universität Hannover, Germany
Invited Short Talk: ssNMR of RNA and RNP Complexes

Tuesday, March 14 | 8:00AM - 11:00AM
Protein-Nucleic Acid Interactions
Room: Grays Peak

Speaker 7 of 7
Michael Sattler, Helmholtz Zentrum München & Technische Universität München, Germany
Conformational Dynamics of Biomolecular Recognition in Gene Regulation

Tuesday, March 14 | 11:00AM - 2:30PM
On Own for Lunch


Tuesday, March 14 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Tuesday, March 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Tuesday, March 14 | 2:30PM - 4:30PM
Workshop 1: Automation in Protein NMR Structure Determinatio
n and Other Hot Topics
Room: Grays Peak

Speaker 1 of 7
* Martin Billeter, University of Zurich, Switzerland

Tuesday, March 14 | 2:30PM - 4:30PM
Workshop 1: Automation in Protein NMR Structure Determinatio
n and Other Hot Topics
Room: Grays Peak

Speaker 2 of 7
Kristaps Jaudzems, Institut des Sciences Analytiques, France
Solution NMR Conquers Solids with Fast MAS: de novo NMR Structure Determination of a 2.5 MDa Capsid

Tuesday, March 14 | 2:30PM - 4:30PM
Workshop 1: Automation in Protein NMR Structure Determinatio
n and Other Hot Topics
Room: Grays Peak

Speaker 3 of 7
Silke Andrea Wieninger, Institut Pasteur, France
Identification of Incompatible NOE Restraints for Partial Ensemble Structure Determination in ARIA

Tuesday, March 14 | 2:30PM - 4:30PM
Workshop 1: Automation in Protein NMR Structure Determinatio
n and Other Hot Topics
Room: Grays Peak

Speaker 4 of 7
Marielle Aulikki Wälti, National Institutes of Health, USA
Fast Determination of 3D Complex Structures with Low Affinity Binders

Tuesday, March 14 | 2:30PM - 4:30PM
Workshop 1: Automation in Protein NMR Structure Determinatio
n and Other Hot Topics
Room: Grays Peak

Speaker 5 of 7
William J. Placzek, University of Alabama at Birmingham, USA
NMR Studies of Ubc9 Mutant Identify Structural Basis for SUMO Target Selection

Tuesday, March 14 | 2:30PM - 4:30PM
Workshop 1: Automation in Protein NMR Structure Determinatio
n and Other Hot Topics
Room: Grays Peak

Speaker 6 of 7
Joshua D. Brown, University of Maryland, Baltimore County, USA
Influence of the 5' Transcription Start Site Heterogeneity on HIV RNA Structure and Fate

Tuesday, March 14 | 2:30PM - 4:30PM
Workshop 1: Automation in Protein NMR Structure Determinatio
n and Other Hot Topics
Room: Grays Peak

Speaker 7 of 7
Shin Isogai, Biozentrum, Basel University, Switzerland
Backbone Solution NMR of GPCRs: A Case Study of the Engineered Beta1-Adrenergic receptor

Tuesday, March 14 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, March 14 | 5:00PM - 7:00PM
Integrative Structural Biology
Room: Grays Peak

Speaker 1 of 4
* John L. Markley, University of Wisconsin-Madison, USA

Tuesday, March 14 | 5:00PM - 7:00PM
Integrative Structural Biology
Room: Grays Peak

Speaker 2 of 4
Andrej Sali, University of California, San Francisco, USA
Integrative Modeling of Biomolecular Assembly Structures and Pathways

Tuesday, March 14 | 5:00PM - 7:00PM
Integrative Structural Biology
Room: Grays Peak

Speaker 3 of 4
Juli Feigon, University of California, Los Angeles, USA
Integrative Structural Biology of Telomerase

Tuesday, March 14 | 5:00PM - 7:00PM
Integrative Structural Biology
Room: Grays Peak

Speaker 4 of 4
Michael Nilges, Institut Pasteur, France
Integrative Structural Biology of a Type II Secretion Pseudopilus


Tuesday, March 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Tuesday, March 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Wednesday, March 15 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Wednesday, March 15 | 8:00AM - 11:00AM
NMR in Drug Research
Room: Grays Peak

Speaker 1 of 6
* Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA

Wednesday, March 15 | 8:00AM - 11:00AM
NMR in Drug Research
Room: Grays Peak

Speaker 2 of 6
Maurizio Pellecchia, University of California, Riverside, USA
NMR-Guided Discovery of Novel Pharmacological Tools and Therapeutics

Wednesday, March 15 | 8:00AM - 11:00AM
NMR in Drug Research
Room: Grays Peak

Speaker 3 of 6
Dorothee Kern, Brandeis University, HHMI, USA
Exploiting Protein Dynamics for Novel Strategies in Drug Design

Wednesday, March 15 | 8:00AM - 11:00AM
NMR in Drug Research
Room: Grays Peak


Coffee Break

Wednesday, March 15 | 8:00AM - 11:00AM
NMR in Drug Research
Room: Grays Peak

Speaker 5 of 6
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Cancer Drug Discovery Using Fragment-Based Methods

Wednesday, March 15 | 8:00AM - 11:00AM
NMR in Drug Research
Room: Grays Peak

Speaker 6 of 6
Robert G. Brinson, National Institute of Standards and Technology, USA
Practical NMR Applications for Structural Assessment of Monoclonal Antibody Therapeutics

Wednesday, March 15 | 11:00AM - 2:30PM
On Own for Lunch


Wednesday, March 15 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Wednesday, March 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Wednesday, March 15 | 2:30PM - 3:30PM
Workshop 2: NMR in Integrative Structural Biology Projects a
nd Other Hot Topics
Room: Grays Peak

Speaker 1 of 4
* Ad Bax, NIDDK, National Institutes of Health, USA
Following Protein Folding in Real Time by Fast Pressure Jump NMR

Wednesday, March 15 | 2:30PM - 3:30PM
Workshop 2: NMR in Integrative Structural Biology Projects a
nd Other Hot Topics
Room: Grays Peak

Speaker 2 of 4
Daniel Stöppler, Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany, Germany
Dynamic Nuclear Polarization Provides New Insights into Chromophore Structure in Phytochrome Photoreceptors

Wednesday, March 15 | 2:30PM - 3:30PM
Workshop 2: NMR in Integrative Structural Biology Projects a
nd Other Hot Topics
Room: Grays Peak

Speaker 3 of 4
Tobias Madl, Medical University of Graz, Austria
Structural Characterization of Biomolecules using Solvent-Accessibility Data

Wednesday, March 15 | 2:30PM - 3:30PM
Workshop 2: NMR in Integrative Structural Biology Projects a
nd Other Hot Topics
Room: Grays Peak

Speaker 4 of 4
Nikolaos G. Sgourakis, University of California, Santa Cruz, USA
An Allosteric Site in the T Cell Receptor beta-Chain Constant Domain Plays a Critical Role in T Cell Signaling

Wednesday, March 15 | 3:30PM - 4:30PM
Panel: NMR in Integrative Structural Biology Projects
Room: Grays Peak

Speaker 1 of 5
* Ad Bax, NIDDK, National Institutes of Health, USA

Wednesday, March 15 | 3:30PM - 4:30PM
Panel: NMR in Integrative Structural Biology Projects
Room: Grays Peak

Speaker 2 of 5
Frédéric H.T. Allain, ETH Zurich, Switzerland

Wednesday, March 15 | 3:30PM - 4:30PM
Panel: NMR in Integrative Structural Biology Projects
Room: Grays Peak

Speaker 3 of 5
Jonathan Pritz, Dana-Farber Cancer Institute, Boston, USA, USA

Wednesday, March 15 | 3:30PM - 4:30PM
Panel: NMR in Integrative Structural Biology Projects
Room: Grays Peak

Speaker 4 of 5
Andrej Sali, University of California, San Francisco, USA

Wednesday, March 15 | 3:30PM - 4:30PM
Panel: NMR in Integrative Structural Biology Projects
Room: Grays Peak

Speaker 5 of 5
Ian A. Wilson, The Scripps Research Institute, USA

Wednesday, March 15 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, March 15 | 5:00PM - 7:00PM
Advances in Solid State NMR Methods in Biology
Room: Grays Peak

Speaker 1 of 5
* Arthur G. Palmer, III, Columbia University, USA

Wednesday, March 15 | 5:00PM - 7:00PM
Advances in Solid State NMR Methods in Biology
Room: Grays Peak

Speaker 2 of 5
Bernd Reif, Technische Universität München, Germany
Soluble Protein Complexes Investigated by MAS Solid-State NMR

Wednesday, March 15 | 5:00PM - 7:00PM
Advances in Solid State NMR Methods in Biology
Room: Grays Peak

Speaker 3 of 5
Marc Baldus, Utrecht University, Netherlands
Cellular Solid-State NMR Applied to Membrane Protein Complexes

Wednesday, March 15 | 5:00PM - 7:00PM
Advances in Solid State NMR Methods in Biology
Room: Grays Peak

Speaker 4 of 5
Paul Schanda, Institut de Biologie Structurale, France
Invited Short Talk: Functional Dynamics in a Half-Megadalton Large Enzyme Complex as Seen by Solid-State NMR

Wednesday, March 15 | 5:00PM - 7:00PM
Advances in Solid State NMR Methods in Biology
Room: Grays Peak

Speaker 5 of 5
Christopher P. Jaroniec, Ohio State University, USA
Invited Short Talk: Structural Studies of Y145Stop Prion Protein Amyloids

Wednesday, March 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Wednesday, March 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Shavano/Torreys


Thursday, March 16 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Thursday, March 16 | 8:00AM - 11:00AM
In-Cell NMR and Intrinsically Disordered Proteins
Room: Grays Peak

Speaker 1 of 6
* Astrid Gräslund, Stockholm University, Sweden

Thursday, March 16 | 8:00AM - 11:00AM
In-Cell NMR and Intrinsically Disordered Proteins
Room: Grays Peak

Speaker 2 of 6
Ichio Shimada, University of Tokyo, Japan
Studying Proteins inside Eukaryotic Cells in NMR

Thursday, March 16 | 8:00AM - 11:00AM
In-Cell NMR and Intrinsically Disordered Proteins
Room: Grays Peak

Speaker 3 of 6
Richard W. Kriwacki, St. Jude Children's Research Hospital, USA
Structure and Dynamics of IDPs from NMR; Applications from Small Molecule Interactions to Phase Separation

Thursday, March 16 | 8:00AM - 11:00AM
In-Cell NMR and Intrinsically Disordered Proteins
Room: Grays Peak


Coffee Break

Thursday, March 16 | 8:00AM - 11:00AM
In-Cell NMR and Intrinsically Disordered Proteins
Room: Grays Peak

Speaker 5 of 6
Peter E. Wright, The Scripps Research Institute, USA
NMR Characterization of Intrinsically Disordered Regulatory Proteins

Thursday, March 16 | 8:00AM - 11:00AM
In-Cell NMR and Intrinsically Disordered Proteins
Room: Grays Peak

Speaker 6 of 6
Martin Blackledge, Institut de Biologie Structurale, France
Large-Scale Conformational Dynamics and Biomolecular Function from NMR

Thursday, March 16 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, March 16 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 16 | 5:00PM - 6:45PM
Solution NMR Studies of Membrane Proteins
Room: Grays Peak

Speaker 1 of 5
* Stephen W. Fesik, Vanderbilt University School of Medicine, USA

Thursday, March 16 | 5:00PM - 6:45PM
Solution NMR Studies of Membrane Proteins
Room: Grays Peak

Speaker 2 of 5
Kurt Wüthrich, ETH Zürich, Switzerland / The Scripps Research Institute, USA, Switzerland
NMR Studies of G Protein-coupled Receptors (GPCR) in Solution



Thursday, March 16 | 5:00PM - 6:45PM
Solution NMR Studies of Membrane Proteins
Room: Grays Peak

Speaker 3 of 5
Daniel Nietlispach, University of Cambridge, UK
Invited Short Talk: Investigating the Dynamic Landscape of GPCRs

Thursday, March 16 | 5:00PM - 6:45PM
Solution NMR Studies of Membrane Proteins
Room: Grays Peak

Speaker 4 of 5
Katherine A. Henzler-Wildman, University of Wisconsin-Madison, USA
Invited Short Talk: The Small Multidrug Resistance Transporter EmrE Sacrifices Efficiency to Achieve Promiscuity


Thursday, March 16 | 5:00PM - 6:45PM
Solution NMR Studies of Membrane Proteins
Room: Grays Peak

Speaker 5 of 5
Gerhard Wagner, Harvard Medical School, USA
Membrane Protein Studies in Micelles and Nanodiscs

Thursday, March 16 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grays Peak


Thursday, March 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Thursday, March 16 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 16 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Friday, March 17 | 10:25AM - 10:25AM
Departure


*Session Chair.