Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
There are no records.

Web Desc
Frontiers of NMR in Life Sciences Organizer(s): Kurt Wüthrich, Michael Sattler and Stephen W. Fesik Date: March 12 - 16, 2017 Location: Keystone Resort, Keystone, CO, USA Sponsored by Merck & Co., Inc. Summary of Meeting: The NMR principle is widely applied in structural biology, biomedical research and clinical diagnosis. This conference will highlight progress in solution and solid state NMR methods and recent advances in selected NMR applications in metabolic profiling, drug research, protein/ nucleic acid interactions, in-cell NMR, intrinsically disordered proteins and the study of membrane proteins. Attendees will obtain an overview of the principal advances made during the last four years with the use of NMR techniques in structural biology and biomedical research, and receive guidance on anticipated mid-term and long-term future advances with NMR applications in molecular and cell biology. Scholarship Deadline: November 15 2016 Discounted Abstract Deadline: November 15 2016 Abstract Deadline: December 13 2016 Discounted Registration Deadline: January 13 2017 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Frontiers of NMR in Life Sciences

Organizer(s): Kurt Wüthrich, Michael Sattler and Stephen W. Fesik

Date: March 12 - 16, 2017
Location: Keystone Resort, Keystone, CO, USA

Program


Sunday, March 12 \| 4:00PM - 8:00PM Arrival and Registration Room: Longs Peak Foyer
Sunday, March 12 \| 6:00PM - 8:00PM Welcome Mixer Room: Longs Peak Foyer No registration fees are used to fund alcohol served at this function.
Monday, March 13 \| 7:00AM - 8:00AM Breakfast Room: Shavano/Torreys
Monday, March 13 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Grays Peak Speaker 1 of 2 * Kurt Wüthrich, ETH Zürich, Switzerland / The Scripps Research Institute, USA, Switzerland
Monday, March 13 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Grays Peak Speaker 2 of 2 Lewis E. Kay, University of Toronto, Canada NMR: Why Bother?
Monday, March 13 \| 9:00AM - 11:15AM Innovative Solution NMR Methods for Studying Biological Macr omolecules Room: Grays Peak Speaker 1 of 6 * Michael Sattler, Helmholtz Zentrum München & Technische Universität München, Germany
Monday, March 13 \| 9:00AM - 11:15AM Innovative Solution NMR Methods for Studying Biological Macr omolecules Room: Grays Peak Speaker 2 of 6 Dominique P. Frueh, Johns Hopkins University School of Medicine, USA Invited Short Talk: Overcoming Challenges in NMR Studies of Large and Dynamic Nonribosomal Peptide Synthetases
Monday, March 13 \| 9:00AM - 11:15AM Innovative Solution NMR Methods for Studying Biological Macr omolecules Room: Grays Peak Speaker 3 of 6 Wolfgang Peti, University of Arizona, USA Invited Short Talk: Using Dynamics and Structure to Understand Allostery in Signaling Enzymes
Monday, March 13 \| 9:00AM - 11:15AM Innovative Solution NMR Methods for Studying Biological Macr omolecules Room: Grays Peak Coffee Break
Monday, March 13 \| 9:00AM - 11:15AM Innovative Solution NMR Methods for Studying Biological Macr omolecules Room: Grays Peak Speaker 5 of 6 Haribabu Arthanari, Harvard Medical School, USA Invited Short Talk: Increasing Resolution of Backbone Experiments: Thinking Beyond the Nyqvist Grid
Monday, March 13 \| 9:00AM - 11:15AM Innovative Solution NMR Methods for Studying Biological Macr omolecules Room: Grays Peak Speaker 6 of 6 Christian Griesinger, Max Planck Institute for Biophysical Chemistry, Germany NMR-Based Structural Biology in Immunity and Neurodegeneration/Protectoin
Monday, March 13 \| 11:15AM - 5:00PM On Own for Lunch
Monday, March 13 \| 11:15AM - 1:00PM Poster Setup Room: Shavano/Torreys
Monday, March 13 \| 1:00PM - 10:00PM Poster Viewing Room: Shavano/Torreys
Monday, March 13 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, March 13 \| 5:00PM - 7:00PM Use of NMR in Metabolic Profiling Room: Grays Peak Speaker 1 of 4 * Jane Dyson, The Scripps Research Institute, USA
Monday, March 13 \| 5:00PM - 7:00PM Use of NMR in Metabolic Profiling Room: Grays Peak Speaker 2 of 4 Teresa W. M. Fan, University of Kentucky Markey Cancer Center, USA Metabolic Network Mapping by Stable Isotope Resolved Metabolomics (SIRM)
Monday, March 13 \| 5:00PM - 7:00PM Use of NMR in Metabolic Profiling Room: Grays Peak Speaker 3 of 4 Rafael Brüschweiler, Ohio State University, USA NMR and NMR/MS Hybrid Approaches for Targeted and Untargeted Metabolomics
Monday, March 13 \| 5:00PM - 7:00PM Use of NMR in Metabolic Profiling Room: Grays Peak Speaker 4 of 4 Michael A. Kennedy, Miami University, USA NMR-Based Metabolic Profiling of Human Diseases
Monday, March 13 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Monday, March 13 \| 7:30PM - 10:00PM Poster Session 1 Room: Shavano/Torreys
Tuesday, March 14 \| 7:00AM - 8:00AM Breakfast Room: Shavano/Torreys
Tuesday, March 14 \| 8:00AM - 11:00AM Protein-Nucleic Acid Interactions Room: Grays Peak Speaker 1 of 7 * Robert Kaptein, University of Utrecht, Netherlands
Tuesday, March 14 \| 8:00AM - 11:00AM Protein-Nucleic Acid Interactions Room: Grays Peak Speaker 2 of 7 Frédéric H.T. Allain, ETH Zurich, Switzerland Structures of Protein RNA Complexes using Hybrid Structural Approaches
Tuesday, March 14 \| 8:00AM - 11:00AM Protein-Nucleic Acid Interactions Room: Grays Peak Speaker 3 of 7 Hashim M. Al-Hashimi, Duke University, USA Visualizing Transient Watson-Crick Mispairs in DNA and RNA Duplexes
Tuesday, March 14 \| 8:00AM - 11:00AM Protein-Nucleic Acid Interactions Room: Grays Peak Coffee Break
Tuesday, March 14 \| 8:00AM - 11:00AM Protein-Nucleic Acid Interactions Room: Grays Peak Speaker 5 of 7 Pedro Serrano-Navarro, The Scripps Research Institute, USA Invited Short Talk: In vitro Studies of Arginine-Serine-Rich Domains
Tuesday, March 14 \| 8:00AM - 11:00AM Protein-Nucleic Acid Interactions Room: Grays Peak Speaker 6 of 7 Teresa Carlomagno, Universität Hannover, Germany Invited Short Talk: ssNMR of RNA and RNP Complexes
Tuesday, March 14 \| 8:00AM - 11:00AM Protein-Nucleic Acid Interactions Room: Grays Peak Speaker 7 of 7 Michael Sattler, Helmholtz Zentrum München & Technische Universität München, Germany Conformational Dynamics of Biomolecular Recognition in Gene Regulation
Tuesday, March 14 \| 11:00AM - 2:30PM On Own for Lunch
Tuesday, March 14 \| 11:00AM - 1:00PM Poster Setup Room: Shavano/Torreys
Tuesday, March 14 \| 1:00PM - 10:00PM Poster Viewing Room: Shavano/Torreys
Tuesday, March 14 \| 2:30PM - 4:30PM Workshop 1: Automation in Protein NMR Structure Determinatio n and Other Hot Topics Room: Grays Peak Speaker 1 of 7 * Martin Billeter, University of Zurich, Switzerland
Tuesday, March 14 \| 2:30PM - 4:30PM Workshop 1: Automation in Protein NMR Structure Determinatio n and Other Hot Topics Room: Grays Peak Speaker 2 of 7 Kristaps Jaudzems, Institut des Sciences Analytiques, France Solution NMR Conquers Solids with Fast MAS: de novo NMR Structure Determination of a 2.5 MDa Capsid
Tuesday, March 14 \| 2:30PM - 4:30PM Workshop 1: Automation in Protein NMR Structure Determinatio n and Other Hot Topics Room: Grays Peak Speaker 3 of 7 Silke Andrea Wieninger, Institut Pasteur, France Identification of Incompatible NOE Restraints for Partial Ensemble Structure Determination in ARIA
Tuesday, March 14 \| 2:30PM - 4:30PM Workshop 1: Automation in Protein NMR Structure Determinatio n and Other Hot Topics Room: Grays Peak Speaker 4 of 7 Marielle Aulikki Wälti, National Institutes of Health, USA Fast Determination of 3D Complex Structures with Low Affinity Binders
Tuesday, March 14 \| 2:30PM - 4:30PM Workshop 1: Automation in Protein NMR Structure Determinatio n and Other Hot Topics Room: Grays Peak Speaker 5 of 7 William J. Placzek, University of Alabama at Birmingham, USA NMR Studies of Ubc9 Mutant Identify Structural Basis for SUMO Target Selection
Tuesday, March 14 \| 2:30PM - 4:30PM Workshop 1: Automation in Protein NMR Structure Determinatio n and Other Hot Topics Room: Grays Peak Speaker 6 of 7 Joshua D. Brown, University of Maryland, Baltimore County, USA Influence of the 5' Transcription Start Site Heterogeneity on HIV RNA Structure and Fate
Tuesday, March 14 \| 2:30PM - 4:30PM Workshop 1: Automation in Protein NMR Structure Determinatio n and Other Hot Topics Room: Grays Peak Speaker 7 of 7 Shin Isogai, Biozentrum, Basel University, Switzerland Backbone Solution NMR of GPCRs: A Case Study of the Engineered Beta1-Adrenergic receptor
Tuesday, March 14 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, March 14 \| 5:00PM - 7:00PM Integrative Structural Biology Room: Grays Peak Speaker 1 of 4 * John L. Markley, University of Wisconsin-Madison, USA
Tuesday, March 14 \| 5:00PM - 7:00PM Integrative Structural Biology Room: Grays Peak Speaker 2 of 4 Andrej Sali, University of California, San Francisco, USA Integrative Modeling of Biomolecular Assembly Structures and Pathways
Tuesday, March 14 \| 5:00PM - 7:00PM Integrative Structural Biology Room: Grays Peak Speaker 3 of 4 Juli Feigon, University of California, Los Angeles, USA Integrative Structural Biology of Telomerase
Tuesday, March 14 \| 5:00PM - 7:00PM Integrative Structural Biology Room: Grays Peak Speaker 4 of 4 Michael Nilges, Institut Pasteur, France Integrative Structural Biology of a Type II Secretion Pseudopilus
Tuesday, March 14 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Tuesday, March 14 \| 7:30PM - 10:00PM Poster Session 2 Room: Shavano/Torreys
Wednesday, March 15 \| 7:00AM - 8:00AM Breakfast Room: Shavano/Torreys
Wednesday, March 15 \| 8:00AM - 11:00AM NMR in Drug Research Room: Grays Peak Speaker 1 of 6 * Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
Wednesday, March 15 \| 8:00AM - 11:00AM NMR in Drug Research Room: Grays Peak Speaker 2 of 6 Maurizio Pellecchia, University of California, Riverside, USA NMR-Guided Discovery of Novel Pharmacological Tools and Therapeutics
Wednesday, March 15 \| 8:00AM - 11:00AM NMR in Drug Research Room: Grays Peak Speaker 3 of 6 Dorothee Kern, Brandeis University, HHMI, USA Exploiting Protein Dynamics for Novel Strategies in Drug Design
Wednesday, March 15 \| 8:00AM - 11:00AM NMR in Drug Research Room: Grays Peak Coffee Break
Wednesday, March 15 \| 8:00AM - 11:00AM NMR in Drug Research Room: Grays Peak Speaker 5 of 6 Stephen W. Fesik, Vanderbilt University School of Medicine, USA Cancer Drug Discovery Using Fragment-Based Methods
Wednesday, March 15 \| 8:00AM - 11:00AM NMR in Drug Research Room: Grays Peak Speaker 6 of 6 Robert G. Brinson, National Institute of Standards and Technology, USA Practical NMR Applications for Structural Assessment of Monoclonal Antibody Therapeutics
Wednesday, March 15 \| 11:00AM - 2:30PM On Own for Lunch
Wednesday, March 15 \| 11:00AM - 1:00PM Poster Setup Room: Shavano/Torreys
Wednesday, March 15 \| 1:00PM - 10:00PM Poster Viewing Room: Shavano/Torreys
Wednesday, March 15 \| 2:30PM - 3:30PM Workshop 2: NMR in Integrative Structural Biology Projects a nd Other Hot Topics Room: Grays Peak Speaker 1 of 4 * Ad Bax, NIDDK, National Institutes of Health, USA Following Protein Folding in Real Time by Fast Pressure Jump NMR
Wednesday, March 15 \| 2:30PM - 3:30PM Workshop 2: NMR in Integrative Structural Biology Projects a nd Other Hot Topics Room: Grays Peak Speaker 2 of 4 Daniel Stöppler, Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany, Germany Dynamic Nuclear Polarization Provides New Insights into Chromophore Structure in Phytochrome Photoreceptors
Wednesday, March 15 \| 2:30PM - 3:30PM Workshop 2: NMR in Integrative Structural Biology Projects a nd Other Hot Topics Room: Grays Peak Speaker 3 of 4 Tobias Madl, Medical University of Graz, Austria Structural Characterization of Biomolecules using Solvent-Accessibility Data
Wednesday, March 15 \| 2:30PM - 3:30PM Workshop 2: NMR in Integrative Structural Biology Projects a nd Other Hot Topics Room: Grays Peak Speaker 4 of 4 Nikolaos G. Sgourakis, University of California, Santa Cruz, USA An Allosteric Site in the T Cell Receptor beta-Chain Constant Domain Plays a Critical Role in T Cell Signaling
Wednesday, March 15 \| 3:30PM - 4:30PM Panel: NMR in Integrative Structural Biology Projects Room: Grays Peak Speaker 1 of 5 * Ad Bax, NIDDK, National Institutes of Health, USA
Wednesday, March 15 \| 3:30PM - 4:30PM Panel: NMR in Integrative Structural Biology Projects Room: Grays Peak Speaker 2 of 5 Frédéric H.T. Allain, ETH Zurich, Switzerland
Wednesday, March 15 \| 3:30PM - 4:30PM Panel: NMR in Integrative Structural Biology Projects Room: Grays Peak Speaker 3 of 5 Jonathan Pritz, Dana-Farber Cancer Institute, Boston, USA, USA
Wednesday, March 15 \| 3:30PM - 4:30PM Panel: NMR in Integrative Structural Biology Projects Room: Grays Peak Speaker 4 of 5 Andrej Sali, University of California, San Francisco, USA
Wednesday, March 15 \| 3:30PM - 4:30PM Panel: NMR in Integrative Structural Biology Projects Room: Grays Peak Speaker 5 of 5 Ian A. Wilson, The Scripps Research Institute, USA
Wednesday, March 15 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, March 15 \| 5:00PM - 7:00PM Advances in Solid State NMR Methods in Biology Room: Grays Peak Speaker 1 of 5 * Arthur G. Palmer, III, Columbia University, USA
Wednesday, March 15 \| 5:00PM - 7:00PM Advances in Solid State NMR Methods in Biology Room: Grays Peak Speaker 2 of 5 Bernd Reif, Technische Universität München, Germany Soluble Protein Complexes Investigated by MAS Solid-State NMR
Wednesday, March 15 \| 5:00PM - 7:00PM Advances in Solid State NMR Methods in Biology Room: Grays Peak Speaker 3 of 5 Marc Baldus, Utrecht University, Netherlands Cellular Solid-State NMR Applied to Membrane Protein Complexes
Wednesday, March 15 \| 5:00PM - 7:00PM Advances in Solid State NMR Methods in Biology Room: Grays Peak Speaker 4 of 5 Paul Schanda, Institut de Biologie Structurale, France Invited Short Talk: Functional Dynamics in a Half-Megadalton Large Enzyme Complex as Seen by Solid-State NMR
Wednesday, March 15 \| 5:00PM - 7:00PM Advances in Solid State NMR Methods in Biology Room: Grays Peak Speaker 5 of 5 Christopher P. Jaroniec, Ohio State University, USA Invited Short Talk: Structural Studies of Y145Stop Prion Protein Amyloids
Wednesday, March 15 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Wednesday, March 15 \| 7:30PM - 10:00PM Poster Session 3 Room: Shavano/Torreys
Thursday, March 16 \| 7:00AM - 8:00AM Breakfast Room: Shavano/Torreys
Thursday, March 16 \| 8:00AM - 11:00AM In-Cell NMR and Intrinsically Disordered Proteins Room: Grays Peak Speaker 1 of 6 * Astrid Gräslund, Stockholm University, Sweden
Thursday, March 16 \| 8:00AM - 11:00AM In-Cell NMR and Intrinsically Disordered Proteins Room: Grays Peak Speaker 2 of 6 Ichio Shimada, University of Tokyo, Japan Studying Proteins inside Eukaryotic Cells in NMR
Thursday, March 16 \| 8:00AM - 11:00AM In-Cell NMR and Intrinsically Disordered Proteins Room: Grays Peak Speaker 3 of 6 Richard W. Kriwacki, St. Jude Children's Research Hospital, USA Structure and Dynamics of IDPs from NMR; Applications from Small Molecule Interactions to Phase Separation
Thursday, March 16 \| 8:00AM - 11:00AM In-Cell NMR and Intrinsically Disordered Proteins Room: Grays Peak Coffee Break
Thursday, March 16 \| 8:00AM - 11:00AM In-Cell NMR and Intrinsically Disordered Proteins Room: Grays Peak Speaker 5 of 6 Peter E. Wright, The Scripps Research Institute, USA NMR Characterization of Intrinsically Disordered Regulatory Proteins
Thursday, March 16 \| 8:00AM - 11:00AM In-Cell NMR and Intrinsically Disordered Proteins Room: Grays Peak Speaker 6 of 6 Martin Blackledge, Institut de Biologie Structurale, France Large-Scale Conformational Dynamics and Biomolecular Function from NMR
Thursday, March 16 \| 11:00AM - 5:00PM On Own for Lunch
Thursday, March 16 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, March 16 \| 5:00PM - 6:45PM Solution NMR Studies of Membrane Proteins Room: Grays Peak Speaker 1 of 5 * Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Thursday, March 16 \| 5:00PM - 6:45PM Solution NMR Studies of Membrane Proteins Room: Grays Peak Speaker 2 of 5 Kurt Wüthrich, ETH Zürich, Switzerland / The Scripps Research Institute, USA, Switzerland NMR Studies of G Protein-coupled Receptors (GPCR) in Solution
Thursday, March 16 \| 5:00PM - 6:45PM Solution NMR Studies of Membrane Proteins Room: Grays Peak Speaker 3 of 5 Daniel Nietlispach, University of Cambridge, UK Invited Short Talk: Investigating the Dynamic Landscape of GPCRs
Thursday, March 16 \| 5:00PM - 6:45PM Solution NMR Studies of Membrane Proteins Room: Grays Peak Speaker 4 of 5 Katherine A. Henzler-Wildman, University of Wisconsin-Madison, USA Invited Short Talk: The Small Multidrug Resistance Transporter EmrE Sacrifices Efficiency to Achieve Promiscuity
Thursday, March 16 \| 5:00PM - 6:45PM Solution NMR Studies of Membrane Proteins Room: Grays Peak Speaker 5 of 5 Gerhard Wagner, Harvard Medical School, USA Membrane Protein Studies in Micelles and Nanodiscs
Thursday, March 16 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Grays Peak
Thursday, March 16 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys No registration fees are used to fund alcohol served at this function.
Thursday, March 16 \| 8:00PM - 11:00PM Entertainment Room: Shavano/Torreys Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, March 16 \| 8:00PM - 11:00PM Cash Bar Room: Shavano/Torreys
Friday, March 17 \| 10:25AM - 10:25AM Departure *Session Chair.