Web Desc
Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity
Organizer(s): Franck Mauvais-Jarvis, Deborah Clegg and Arthur P. Arnold
Date: March 19 - 22, 2017
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is the generation of data that risks being relevant to only half of the population. This is a timely moment to study sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men. The goal of this meeting is to fill a need in the scientific community by connecting interdisciplinary groups of scientists who normally would not have an opportunity to interact. This group includes investigators studying sex differences, the role of sex hormones, the systems biology of sex and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. Leaders of the pharmaceutical industry will present their views on sex-specific drug discovery. The meeting is expected to generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level, and to provide the methods to study them. It is intended to be a catalyst of a process that will lead to gender-specific treatments of metabolic diseases.
Scholarship Deadline: November 15 2016
Discounted Abstract Deadline: November 15 2016
Abstract Deadline: December 19 2016
Discounted Registration Deadline: January 18 2017
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Molecular Metabolism (Elsevier GmbH)
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK112660-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function


Sunday, March 19 | 6:00PM - 8:00PM
Welcome Mixer
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Sunday, March 19 | 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall


Monday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, March 20 | 8:00AM - 9:00AM
Welcome (Organizers) and Keynote Address
Room: Mountain/Lake

Speaker 1 of 1
David C. Page, Whitehead Institute for Biomedical Research, USA
Sex and Disease: Do Males and Females Read their Genomes Differently?

Monday, March 20 | 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake

Speaker 1 of 8
* Andrea L. Hevener, University of California, Los Angeles, USA

Monday, March 20 | 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake

Speaker 2 of 8
Susan K. Fried, Icahn School of Medicine at Mount Sinai, USA
Sex Differences in Adipose Biology

Monday, March 20 | 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake


Coffee Break

Monday, March 20 | 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake

Speaker 4 of 8
Charles T. Roberts, Oregon National Primate Research Center, USA
Sex-Specific Effects of Androgens on Adipose Tissue Biology

Monday, March 20 | 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake

Speaker 5 of 8
Jayne S. Danska, Hospital for Sick Children Research Institute, Canada
Regulation of Diabetes by Genes, Sex and the Microbiome

Monday, March 20 | 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake

Speaker 6 of 8
Karlton R. Larson, University of California, Davis, USA
Short Talk: Sex Differences in the Metabolic Response to Dietary Protein Dilution and FGF21

Monday, March 20 | 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake

Speaker 7 of 8
Brian Finan, Novo Nordisk, USA
Short Talk: GLP-1/GIP/Glucagon Triagonism Corrects Metabolic Disease in Female Mice

Monday, March 20 | 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake

Speaker 8 of 8
Margreet Vonk Noordegraaf, Erasmus MC, Netherlands
Short Talk: AMH Signaling Deficiency Causes Sex-Dependent Metabolic Alterations in Mice

Monday, March 20 | 11:45AM - 2:30PM
On Own for Lunch


Monday, March 20 | 11:45AM - 1:00PM
Poster Setup
Room: Bay


Monday, March 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Designing Pre-Clinical Studies to Conduct Resear
ch on Sex Differences
Room: Mountain/Lake

Speaker 1 of 3
* Karen Reue, University of California, Los Angeles, USA

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Designing Pre-Clinical Studies to Conduct Resear
ch on Sex Differences
Room: Mountain/Lake

Speaker 2 of 3
Franck Mauvais-Jarvis, Tulane University Health Sciences Center, USA

Monday, March 20 | 2:30PM - 4:30PM
Workshop 1: Designing Pre-Clinical Studies to Conduct Resear
ch on Sex Differences
Room: Mountain/Lake

Speaker 3 of 3
Arthur P. Arnold, University of California, Los Angeles, USA

Monday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, March 20 | 5:00PM - 7:00PM
Sex Differences in Metabolic Homeostasis II
Room: Mountain/Lake

Speaker 1 of 5
* Darleen A. Sandoval, University of Michigan, USA

Monday, March 20 | 5:00PM - 7:00PM
Sex Differences in Metabolic Homeostasis II
Room: Mountain/Lake

Speaker 2 of 5
Miriam Bredella, Massachusetts General Hospital, USA
Sex Differences in Body Composition

Monday, March 20 | 5:00PM - 7:00PM
Sex Differences in Metabolic Homeostasis II
Room: Mountain/Lake

Speaker 3 of 5
Jean-François Gautier, Paris VII University School of Medicine, France
Sex Differences in Diabetes Risk in Offspring after Fetal Exposure to Maternal Diabetes

Monday, March 20 | 5:00PM - 7:00PM
Sex Differences in Metabolic Homeostasis II
Room: Mountain/Lake

Speaker 4 of 5
Christopher B. Newgard, Duke University Medical Center, USA
Sex Differences in the Human Metabolome

Monday, March 20 | 5:00PM - 7:00PM
Sex Differences in Metabolic Homeostasis II
Room: Mountain/Lake

Speaker 5 of 5
Kirstie K. Danielson, University of Illinois at Chicago, USA
Short Talk: Sex Differences in, and Associations of Estrogen with, Human Islet Survival and Function Following Islet Cell Transplant

Monday, March 20 | 7:00PM - 8:00PM
Dinner
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Monday, March 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay


Monday, March 20 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Tuesday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, March 21 | 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake

Speaker 1 of 8
* John M. Stafford, Vanderbilt University, USA

Tuesday, March 21 | 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake

Speaker 2 of 8
Deborah Clegg, Cedars-Sinai Medical Center, USA
Estrogens, through Activation of Membrane Estrogen Receptor Alpha, Potentiate Beiging of Adipose Tissues

Tuesday, March 21 | 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake

Speaker 3 of 8
Holly A. Ingraham, University of California, San Francisco, USA
Sex–Specific Modulation of Energy Homeostasis via Estrogen-Responsive Neurocircuits

Tuesday, March 21 | 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake


Coffee Break

Tuesday, March 21 | 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake

Speaker 5 of 8
Andrea L. Hevener, University of California, Los Angeles, USA
The Impact of ER-alpha in the Regulation of Mitochondrial and Metabolic Health

Tuesday, March 21 | 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake

Speaker 6 of 8
Miguel López, Universidad de Santiago de Compostela, Spain
Estrogen Regulation of Brown Adipose Tissue Thermogenesis

Tuesday, March 21 | 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake

Speaker 7 of 8
Yong Xu, Baylor College of Medicine, USA
Short Talk: TAp63 Contributes to Sexual Dimorphism in POMC Neuron Firing and Diet-Induced Obesity

Tuesday, March 21 | 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake

Speaker 8 of 8
Lin Zhu, Vanderbilt University School of Medicine, USA
Short Talk: Absence of Liver Estrogen Alpha Signaling Predisposes Mice to Atherosclerosis during Western-Type Diet Feeding

Tuesday, March 21 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, March 21 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake

Speaker 1 of 9
* Pierre Gourdy, INSERM DRTLS, France

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake

Speaker 2 of 9
Alexandra L. Cara, University of Michigan, USA
Androgen Receptor Expression in Chemically Defined Hypothalamic Nuclei Associated with Energy Balance

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake

Speaker 3 of 9
Sebastian I. Arriola Apelo, University of Wisconsin-Madison, USA
Male and Female Sex Hormones Determine Metabolic Effects of Hepatic mTORC2

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake

Speaker 4 of 9
Aurele Besse-Patin, Montreal Neurological Institute, Canada
Estrogen Signals through PGC-1alpha to Reduce Oxidative Stress Associated with Diet-Induced Fatty Liver Disease

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake

Speaker 5 of 9
Marion M.C. Korach-André, Karolinska Institute, Sweden
Differential Fatty Acids and Lysophospholipids Composition in Adipose Depots and in Liver May Drive the Sexual Dimorphism in Obesity

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake

Speaker 6 of 9
Samantha Laber, University of Oxford, UK
Do Functional Elements within the Fto Locus Have Sex-Specific Effects?

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake

Speaker 7 of 9
Kanakadurga Singer, University of Michigan, USA
Androgens Potentiate Myeloid Inflammatory Responses to Diet-Induced Obesity

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake

Speaker 8 of 9
Matthew A. Quinn, NIEHS, National Institutes of Health, USA
Estrogen Deficiency Promotes Hepatic Steatosis via Aberrant Glucocorticoid Receptor Signaling

Tuesday, March 21 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake

Speaker 9 of 9
Yukitomo Arao, NIEHS, National Institutes of Health, USA
Estrogen and Androgen Signaling in Female Hepatic Steatosis

Tuesday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, March 21 | 5:00PM - 7:00PM
Androgen and Metabolic Homeostasis
Room: Mountain/Lake

Speaker 1 of 5
* Charles T. Roberts, Oregon National Primate Research Center, USA

Tuesday, March 21 | 5:00PM - 7:00PM
Androgen and Metabolic Homeostasis
Room: Mountain/Lake

Speaker 2 of 5
Franck Mauvais-Jarvis, Tulane University Health Sciences Center, USA
Role of Estrogen and Androgen in Pancreatic Islet Dysfunction in Males and Females

Tuesday, March 21 | 5:00PM - 7:00PM
Androgen and Metabolic Homeostasis
Room: Mountain/Lake

Speaker 3 of 5
Vasantha Padmanabhan, University of Michigan, USA
Developmental Programming of Insulin Resistance in Female Sheep: Is Androgen the Culprit?

Tuesday, March 21 | 5:00PM - 7:00PM
Androgen and Metabolic Homeostasis
Room: Mountain/Lake

Speaker 4 of 5
Andrea Dunaif, Icahn School of Medicine at Mount Sinai, USA
Androgens and Metabolic Dysfunction in Women

Tuesday, March 21 | 5:00PM - 7:00PM
Androgen and Metabolic Homeostasis
Room: Mountain/Lake

Speaker 5 of 5
Farid Saad, Bayer AG, Germany
Short Talk: Prevalence of Type 2 Diabetes (T2DM) and Prediabetes in Hypogonadal Men with or without Testosterone Treatment for up to 12 Years, and Effects on Anthropometric Parameters and Glycemic Control

Tuesday, March 21 | 7:00PM - 8:00PM
Dinner
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Tuesday, March 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay


Tuesday, March 21 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Wednesday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, March 22 | 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s

Room: Mountain/Lake

Speaker 1 of 8
* Holly A. Ingraham, University of California, San Francisco, USA

Wednesday, March 22 | 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s

Room: Mountain/Lake

Speaker 2 of 8
Marc-Andre Cornier, University of Colorado, USA
Sex Differences in Brain Response to Food

Wednesday, March 22 | 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s

Room: Mountain/Lake

Speaker 3 of 8
Karen Reue, University of California, Los Angeles, USA
The XX Chromosome Complement Is an Obesity Risk Factor

Wednesday, March 22 | 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s

Room: Mountain/Lake


Coffee Break

Wednesday, March 22 | 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s

Room: Mountain/Lake

Speaker 5 of 8
Cecilia Lindgren, Oxford University, UK
Sexual Dimorphisms in Genetic Loci Linked to Body Fat Distribution



Wednesday, March 22 | 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s

Room: Mountain/Lake

Speaker 6 of 8
Arthur P. Arnold, University of California, Los Angeles, USA
Sex Differences in Systems Biology: The Sexome

Wednesday, March 22 | 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s

Room: Mountain/Lake

Speaker 7 of 8
Nyrie E. Israelian, University of Toronto, Canada
Short Talk: Impact of Sex on Gut Microbial Composition and Mucosal Immunity

Wednesday, March 22 | 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s

Room: Mountain/Lake

Speaker 8 of 8
Eija Laakkonen, University of Jyväskylä, Finland
Short Talk: Serum exomiR Content in Aging Women - Effects of Estrogenic Hormone Replacement Therapy

Wednesday, March 22 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, March 22 | 5:00PM - 6:45PM
Drug Design and Gender-Specific Medicine
Room: Mountain/Lake

Speaker 1 of 4
* Farid Saad, Bayer AG, Germany

Wednesday, March 22 | 5:00PM - 6:45PM
Drug Design and Gender-Specific Medicine
Room: Mountain/Lake

Speaker 2 of 4
James Trevaskis, Gilead, USA
Enhanced Metabolic Actions of Amylin in Estrogen-Deficiency

Wednesday, March 22 | 5:00PM - 6:45PM
Drug Design and Gender-Specific Medicine
Room: Mountain/Lake

Speaker 3 of 4
Alan J. Russell, Edgewise Therapeutics, USA
Development of Selective Androgen Receptor Modulators (SARMs) and their Sex-Selective Actions

Wednesday, March 22 | 5:00PM - 6:45PM
Drug Design and Gender-Specific Medicine
Room: Mountain/Lake

Speaker 4 of 4
Richard D. DiMarchi, Indiana University and Novo Nordisk, USA
Chemical Biotechnology Applied to Metabolic Diseases

Wednesday, March 22 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Mountain/Lake


Wednesday, March 22 | 7:00PM - 8:00PM
Dinner
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Wednesday, March 22 | 7:00PM - 8:00PM
Social Hour
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Wednesday, March 22 | 8:00PM - 11:00PM
Entertainment
Room: Granhall
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Wednesday, March 22 | 8:00PM - 11:00PM
Cash Bar
Room: Granhall


Thursday, March 23 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.