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Web Desc
Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity
Organizer(s): Franck Mauvais-Jarvis, Deborah Clegg and Arthur P. Arnold
Date: March 19 - 22, 2017
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by the Directors' Fund
For important information on the coronavirus, please
click here
Summary of Meeting:
There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is the generation of data that risks being relevant to only half of the population. This is a timely moment to study sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men. The goal of this meeting is to fill a need in the scientific community by connecting interdisciplinary groups of scientists who normally would not have an opportunity to interact. This group includes investigators studying sex differences, the role of sex hormones, the systems biology of sex and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. Leaders of the pharmaceutical industry will present their views on sex-specific drug discovery. The meeting is expected to generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level, and to provide the methods to study them. It is intended to be a catalyst of a process that will lead to gender-specific treatments of metabolic diseases.
Scholarship Deadline: November 15 2016
Discounted Abstract Deadline: November 15 2016
Abstract Deadline: December 19 2016
Discounted Registration Deadline: January 18 2017
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
We gratefully acknowledge the generous grant for this conference provided by:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK112660-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
Program
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Sunday, March 19
| 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function
Sunday, March 19
| 6:00PM - 8:00PM
Welcome Mixer
Room: Granhall
No registration fees are used to fund alcohol served at this function.
Sunday, March 19
| 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall
Monday, March 20
| 7:00AM - 8:00AM
Breakfast
Room: Granhall
Monday, March 20
| 8:00AM - 9:00AM
Welcome (Organizers) and Keynote Address
Room: Mountain/Lake
Speaker 1 of 1
David C. Page
, Whitehead Institute for Biomedical Research, USA
Sex and Disease: Do Males and Females Read their Genomes Differently?
Monday, March 20
| 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake
Speaker 1 of 8
* Andrea L. Hevener
, University of California, Los Angeles, USA
Monday, March 20
| 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake
Speaker 2 of 8
Susan K. Fried
, Icahn School of Medicine at Mount Sinai, USA
Sex Differences in Adipose Biology
Monday, March 20
| 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake
Coffee Break
Monday, March 20
| 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake
Speaker 4 of 8
Charles T. Roberts
, Oregon National Primate Research Center, USA
Sex-Specific Effects of Androgens on Adipose Tissue Biology
Monday, March 20
| 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake
Speaker 5 of 8
Jayne S. Danska
, Hospital for Sick Children Research Institute, Canada
Regulation of Diabetes by Genes, Sex and the Microbiome
Monday, March 20
| 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake
Speaker 6 of 8
Karlton R. Larson
, University of California, Davis, USA
Short Talk: Sex Differences in the Metabolic Response to Dietary Protein Dilution and FGF21
Monday, March 20
| 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake
Speaker 7 of 8
Brian Finan
, Novo Nordisk, USA
Short Talk: GLP-1/GIP/Glucagon Triagonism Corrects Metabolic Disease in Female Mice
Monday, March 20
| 9:00AM - 11:45AM
Sex Differences in Metabolic Homeostasis I
Room: Mountain/Lake
Speaker 8 of 8
Margreet Vonk Noordegraaf
, Erasmus MC, Netherlands
Short Talk: AMH Signaling Deficiency Causes Sex-Dependent Metabolic Alterations in Mice
Monday, March 20
| 11:45AM - 2:30PM
On Own for Lunch
Monday, March 20
| 11:45AM - 1:00PM
Poster Setup
Room: Bay
Monday, March 20
| 1:00PM - 10:00PM
Poster Viewing
Room: Bay
Monday, March 20
| 2:30PM - 4:30PM
Workshop 1: Designing Pre-Clinical Studies to Conduct Resear
ch on Sex Differences
Room: Mountain/Lake
Speaker 1 of 3
* Karen Reue
, University of California, Los Angeles, USA
Monday, March 20
| 2:30PM - 4:30PM
Workshop 1: Designing Pre-Clinical Studies to Conduct Resear
ch on Sex Differences
Room: Mountain/Lake
Speaker 2 of 3
Franck Mauvais-Jarvis
, Tulane University Health Sciences Center, USA
Monday, March 20
| 2:30PM - 4:30PM
Workshop 1: Designing Pre-Clinical Studies to Conduct Resear
ch on Sex Differences
Room: Mountain/Lake
Speaker 3 of 3
Arthur P. Arnold
, University of California, Los Angeles, USA
Monday, March 20
| 4:30PM - 5:00PM
Coffee Available
Room: Pre Function
Monday, March 20
| 5:00PM - 7:00PM
Sex Differences in Metabolic Homeostasis II
Room: Mountain/Lake
Speaker 1 of 5
* Darleen A. Sandoval
, University of Michigan, USA
Monday, March 20
| 5:00PM - 7:00PM
Sex Differences in Metabolic Homeostasis II
Room: Mountain/Lake
Speaker 2 of 5
Miriam Bredella
, Massachusetts General Hospital, USA
Sex Differences in Body Composition
Monday, March 20
| 5:00PM - 7:00PM
Sex Differences in Metabolic Homeostasis II
Room: Mountain/Lake
Speaker 3 of 5
Jean-François Gautier
, Paris VII University School of Medicine, France
Sex Differences in Diabetes Risk in Offspring after Fetal Exposure to Maternal Diabetes
Monday, March 20
| 5:00PM - 7:00PM
Sex Differences in Metabolic Homeostasis II
Room: Mountain/Lake
Speaker 4 of 5
Christopher B. Newgard
, Duke University Medical Center, USA
Sex Differences in the Human Metabolome
Monday, March 20
| 5:00PM - 7:00PM
Sex Differences in Metabolic Homeostasis II
Room: Mountain/Lake
Speaker 5 of 5
Kirstie K. Danielson
, University of Illinois at Chicago, USA
Short Talk: Sex Differences in, and Associations of Estrogen with, Human Islet Survival and Function Following Islet Cell Transplant
Monday, March 20
| 7:00PM - 8:00PM
Dinner
Room: Granhall
No registration fees are used to fund alcohol served at this function.
Monday, March 20
| 7:30PM - 10:00PM
Poster Session 1
Room: Bay
Monday, March 20
| 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.
Tuesday, March 21
| 7:00AM - 8:00AM
Breakfast
Room: Granhall
Tuesday, March 21
| 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake
Speaker 1 of 8
* John M. Stafford
, Vanderbilt University, USA
Tuesday, March 21
| 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake
Speaker 2 of 8
Deborah Clegg
, Cedars-Sinai Medical Center, USA
Estrogens, through Activation of Membrane Estrogen Receptor Alpha, Potentiate Beiging of Adipose Tissues
Tuesday, March 21
| 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake
Speaker 3 of 8
Holly A. Ingraham
, University of California, San Francisco, USA
Sex–Specific Modulation of Energy Homeostasis via Estrogen-Responsive Neurocircuits
Tuesday, March 21
| 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake
Coffee Break
Tuesday, March 21
| 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake
Speaker 5 of 8
Andrea L. Hevener
, University of California, Los Angeles, USA
The Impact of ER-alpha in the Regulation of Mitochondrial and Metabolic Health
Tuesday, March 21
| 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake
Speaker 6 of 8
Miguel López
, Universidad de Santiago de Compostela, Spain
Estrogen Regulation of Brown Adipose Tissue Thermogenesis
Tuesday, March 21
| 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake
Speaker 7 of 8
Yong Xu
, Baylor College of Medicine, USA
Short Talk: TAp63 Contributes to Sexual Dimorphism in POMC Neuron Firing and Diet-Induced Obesity
Tuesday, March 21
| 8:00AM - 11:15AM
Estrogens and Metabolic Homeostasis
Room: Mountain/Lake
Speaker 8 of 8
Lin Zhu
, Vanderbilt University School of Medicine, USA
Short Talk: Absence of Liver Estrogen Alpha Signaling Predisposes Mice to Atherosclerosis during Western-Type Diet Feeding
Tuesday, March 21
| 11:15AM - 5:00PM
On Own for Lunch
Tuesday, March 21
| 11:15AM - 1:00PM
Poster Setup
Room: Bay
Tuesday, March 21
| 1:00PM - 10:00PM
Poster Viewing
Room: Bay
Tuesday, March 21
| 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake
Speaker 1 of 9
* Pierre Gourdy
, INSERM DRTLS, France
Tuesday, March 21
| 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake
Speaker 2 of 9
Alexandra L. Cara
, University of Michigan, USA
Androgen Receptor Expression in Chemically Defined Hypothalamic Nuclei Associated with Energy Balance
Tuesday, March 21
| 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake
Speaker 3 of 9
Sebastian I. Arriola Apelo
, University of Wisconsin-Madison, USA
Male and Female Sex Hormones Determine Metabolic Effects of Hepatic mTORC2
Tuesday, March 21
| 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake
Speaker 4 of 9
Aurele Besse-Patin
, Montreal Neurological Institute, Canada
Estrogen Signals through PGC-1alpha to Reduce Oxidative Stress Associated with Diet-Induced Fatty Liver Disease
Tuesday, March 21
| 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake
Speaker 5 of 9
Marion M.C. Korach-André
, Karolinska Institute, Sweden
Differential Fatty Acids and Lysophospholipids Composition in Adipose Depots and in Liver May Drive the Sexual Dimorphism in Obesity
Tuesday, March 21
| 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake
Speaker 6 of 9
Samantha Laber
, University of Oxford, UK
Do Functional Elements within the Fto Locus Have Sex-Specific Effects?
Tuesday, March 21
| 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake
Speaker 7 of 9
Kanakadurga Singer
, University of Michigan, USA
Androgens Potentiate Myeloid Inflammatory Responses to Diet-Induced Obesity
Tuesday, March 21
| 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake
Speaker 8 of 9
Matthew A. Quinn
, NIEHS, National Institutes of Health, USA
Estrogen Deficiency Promotes Hepatic Steatosis via Aberrant Glucocorticoid Receptor Signaling
Tuesday, March 21
| 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake
Speaker 9 of 9
Yukitomo Arao
, NIEHS, National Institutes of Health, USA
Estrogen and Androgen Signaling in Female Hepatic Steatosis
Tuesday, March 21
| 4:30PM - 5:00PM
Coffee Available
Room: Pre Function
Tuesday, March 21
| 5:00PM - 7:00PM
Androgen and Metabolic Homeostasis
Room: Mountain/Lake
Speaker 1 of 5
* Charles T. Roberts
, Oregon National Primate Research Center, USA
Tuesday, March 21
| 5:00PM - 7:00PM
Androgen and Metabolic Homeostasis
Room: Mountain/Lake
Speaker 2 of 5
Franck Mauvais-Jarvis
, Tulane University Health Sciences Center, USA
Role of Estrogen and Androgen in Pancreatic Islet Dysfunction in Males and Females
Tuesday, March 21
| 5:00PM - 7:00PM
Androgen and Metabolic Homeostasis
Room: Mountain/Lake
Speaker 3 of 5
Vasantha Padmanabhan
, University of Michigan, USA
Developmental Programming of Insulin Resistance in Female Sheep: Is Androgen the Culprit?
Tuesday, March 21
| 5:00PM - 7:00PM
Androgen and Metabolic Homeostasis
Room: Mountain/Lake
Speaker 4 of 5
Andrea Dunaif
, Icahn School of Medicine at Mount Sinai, USA
Androgens and Metabolic Dysfunction in Women
Tuesday, March 21
| 5:00PM - 7:00PM
Androgen and Metabolic Homeostasis
Room: Mountain/Lake
Speaker 5 of 5
Farid Saad
, Bayer AG, Germany
Short Talk: Prevalence of Type 2 Diabetes (T2DM) and Prediabetes in Hypogonadal Men with or without Testosterone Treatment for up to 12 Years, and Effects on Anthropometric Parameters and Glycemic Control
Tuesday, March 21
| 7:00PM - 8:00PM
Dinner
Room: Granhall
No registration fees are used to fund alcohol served at this function.
Tuesday, March 21
| 7:30PM - 10:00PM
Poster Session 2
Room: Bay
Tuesday, March 21
| 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.
Wednesday, March 22
| 7:00AM - 8:00AM
Breakfast
Room: Granhall
Wednesday, March 22
| 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s
Room: Mountain/Lake
Speaker 1 of 8
* Holly A. Ingraham
, University of California, San Francisco, USA
Wednesday, March 22
| 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s
Room: Mountain/Lake
Speaker 2 of 8
Marc-Andre Cornier
, University of Colorado, USA
Sex Differences in Brain Response to Food
Wednesday, March 22
| 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s
Room: Mountain/Lake
Speaker 3 of 8
Karen Reue
, University of California, Los Angeles, USA
The XX Chromosome Complement Is an Obesity Risk Factor
Wednesday, March 22
| 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s
Room: Mountain/Lake
Coffee Break
Wednesday, March 22
| 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s
Room: Mountain/Lake
Speaker 5 of 8
Cecilia Lindgren
, Oxford University, UK
Sexual Dimorphisms in Genetic Loci Linked to Body Fat Distribution
Wednesday, March 22
| 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s
Room: Mountain/Lake
Speaker 6 of 8
Arthur P. Arnold
, University of California, Los Angeles, USA
Sex Differences in Systems Biology: The Sexome
Wednesday, March 22
| 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s
Room: Mountain/Lake
Speaker 7 of 8
Nyrie E. Israelian
, University of Toronto, Canada
Short Talk: Impact of Sex on Gut Microbial Composition and Mucosal Immunity
Wednesday, March 22
| 8:00AM - 11:15AM
Genetics, Metabolomics and Systems Biology of Sex Difference
s
Room: Mountain/Lake
Speaker 8 of 8
Eija Laakkonen
, University of Jyväskylä, Finland
Short Talk: Serum exomiR Content in Aging Women - Effects of Estrogenic Hormone Replacement Therapy
Wednesday, March 22
| 11:00AM - 5:00PM
On Own for Lunch
Wednesday, March 22
| 4:30PM - 5:00PM
Coffee Available
Room: Pre Function
Wednesday, March 22
| 5:00PM - 6:45PM
Drug Design and Gender-Specific Medicine
Room: Mountain/Lake
Speaker 1 of 4
* Farid Saad
, Bayer AG, Germany
Wednesday, March 22
| 5:00PM - 6:45PM
Drug Design and Gender-Specific Medicine
Room: Mountain/Lake
Speaker 2 of 4
James Trevaskis
, Gilead, USA
Enhanced Metabolic Actions of Amylin in Estrogen-Deficiency
Wednesday, March 22
| 5:00PM - 6:45PM
Drug Design and Gender-Specific Medicine
Room: Mountain/Lake
Speaker 3 of 4
Alan J. Russell
, Edgewise Therapeutics, USA
Development of Selective Androgen Receptor Modulators (SARMs) and their Sex-Selective Actions
Wednesday, March 22
| 5:00PM - 6:45PM
Drug Design and Gender-Specific Medicine
Room: Mountain/Lake
Speaker 4 of 4
Richard D. DiMarchi
, Indiana University and Novo Nordisk, USA
Chemical Biotechnology Applied to Metabolic Diseases
Wednesday, March 22
| 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Mountain/Lake
Wednesday, March 22
| 7:00PM - 8:00PM
Dinner
Room: Granhall
No registration fees are used to fund alcohol served at this function.
Wednesday, March 22
| 7:00PM - 8:00PM
Social Hour
Room: Granhall
No registration fees are used to fund alcohol served at this function.
Wednesday, March 22
| 8:00PM - 11:00PM
Entertainment
Room: Granhall
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Wednesday, March 22
| 8:00PM - 11:00PM
Cash Bar
Room: Granhall
Thursday, March 23
| 10:24AM - 10:24AM
Departure
*Session Chair
†Invited, not yet responded.
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