Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
HIV Vaccines (2019X7)
Progress and Pathways Toward an Effective HIV Vaccine (2018J6)

Web Desc
HIV Vaccines Organizer(s): Andrew B. Ward, Penny L. Moore and Robin Shattock Date: March 26 - 30, 2017 Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation. Summary of Meeting: Despite great progress in preventing and treating HIV, new infections continue to plague communities around the world, and the need for an HIV vaccine is as urgent as ever. Several large cohorts of HIV-infected individuals have enabled tremendous advances over the past five years in understanding immune responses to natural HIV infection. These advances have included the isolation of broad and potent anti-HIV antibodies, defining their developmental pathways, the generation of native-like Env trimers for immunization, and high-resolution structures of the envelope glycoprotein in complex with bnAbs. By 2017, many of these discoveries will have enabled new concepts to transition into human clinical trials, including passive monoclonal antibody therapy and novel immunization approaches. These platforms, incorporating improved technology for monitoring immune responses, will drive major advances in the vaccine field. This HIV Vaccines meeting will present the latest results from human clinical studies, along with the cutting-edge basic science behind such trials to highlight approaches that may lead to an HIV vaccine, and also reveal the molecular underpinnings of B and T cell-mediated immunity. Global Health Travel Award Deadline: October 25 2016 Scholarship Deadline: November 29 2016 Discounted Abstract Deadline: November 29 2016 Abstract Deadline: January 10 2017 Discounted Registration Deadline: January 24 2017 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Kymab Limited We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1R13AI129592-01 Funding for this conference was made possible (in part) by AI29592-01 from the National Institute of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

HIV Vaccines

Organizer(s): Andrew B. Ward, Penny L. Moore and Robin Shattock

Date: March 26 - 30, 2017
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation.

Summary of Meeting:

Despite great progress in preventing and treating HIV, new infections continue to plague communities around the world, and the need for an HIV vaccine is as urgent as ever. Several large cohorts of HIV-infected individuals have enabled tremendous advances over the past five years in understanding immune responses to natural HIV infection. These advances have included the isolation of broad and potent anti-HIV antibodies, defining their developmental pathways, the generation of native-like Env trimers for immunization, and high-resolution structures of the envelope glycoprotein in complex with bnAbs. By 2017, many of these discoveries will have enabled new concepts to transition into human clinical trials, including passive monoclonal antibody therapy and novel immunization approaches. These platforms, incorporating improved technology for monitoring immune responses, will drive major advances in the vaccine field. This HIV Vaccines meeting will present the latest results from human clinical studies, along with the cutting-edge basic science behind such trials to highlight approaches that may lead to an HIV vaccine, and also reveal the molecular underpinnings of B and T cell-mediated immunity.

Global Health Travel Award Deadline: October 25 2016

Scholarship Deadline: November 29 2016

Discounted Abstract Deadline: November 29 2016

Abstract Deadline: January 10 2017

Discounted Registration Deadline: January 24 2017

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Kymab Limited

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI129592-01
Funding for this conference was made possible (in part) by AI29592-01 from the National Institute of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 26 \| 4:00PM - 8:00PM Arrival and Registration Room: Foyer
Sunday, March 26 \| 6:00PM - 8:00PM Welcome Mixer Room: Foyer No registration fees are used to fund alcohol served at this function.
Monday, March 27 \| 7:00AM - 8:00AM Breakfast Room: Foyer/Rainbow/Twilight
Monday, March 27 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Storm Peak/Mt. Werner Speaker 1 of 2 * Andrew B. Ward, The Scripps Research Institute, USA
Monday, March 27 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Storm Peak/Mt. Werner Speaker 2 of 2 Nina D. Russell, Bill & Melinda Gates Foundation, USA HIV Vaccines - The Year in Review
Monday, March 27 \| 9:00AM - 11:30AM New Paradigms in Active and Passive Immunization Room: Storm Peak/Mt. Werner Speaker 1 of 7 * Andrew B. Ward, The Scripps Research Institute, USA
Monday, March 27 \| 9:00AM - 11:30AM New Paradigms in Active and Passive Immunization Room: Storm Peak/Mt. Werner Speaker 2 of 7 Michel C. Nussenzweig, HHMI/Rockefeller University, USA Passive Protection with 3BNC117
Monday, March 27 \| 9:00AM - 11:30AM New Paradigms in Active and Passive Immunization Room: Storm Peak/Mt. Werner Speaker 3 of 7 K.Rachael Parks, University of Washington, USA Short Talk: Optimizing the Expansion of Primary VRC01 Antibody Responses by Germline-Targeting Immunogens
Monday, March 27 \| 9:00AM - 11:30AM New Paradigms in Active and Passive Immunization Room: Storm Peak/Mt. Werner Coffee Break
Monday, March 27 \| 9:00AM - 11:30AM New Paradigms in Active and Passive Immunization Room: Storm Peak/Mt. Werner Speaker 5 of 7 Todd C. Bradley, Children's Mercy Kansas City, USA Short Talk: Immune Checkpoint Inhibitor Co-Administration with HIV Env Modifies the Antibody Repertoire
Monday, March 27 \| 9:00AM - 11:30AM New Paradigms in Active and Passive Immunization Room: Storm Peak/Mt. Werner Speaker 6 of 7 Alejandro Balazs, Massachusetts General Hospital, USA Development of Vectored ImmunoProphylaxis and ImmunoTherapy against HIV Infection
Monday, March 27 \| 9:00AM - 11:30AM New Paradigms in Active and Passive Immunization Room: Storm Peak/Mt. Werner Speaker 7 of 7 Jonah B. Sacha, Oregon Health & Science University, USA Cross-Species CMV Vaccination Reveals Viral Determinants for Induction of Non-Classical MHC-E-Restricted T Cells
Monday, March 27 \| 11:30AM - 5:00PM On Own for Lunch
Monday, March 27 \| 11:30AM - 1:00PM Poster Setup Room: Sunshine/Rainbow/Twilight
Monday, March 27 \| 1:00PM - 10:00PM Poster Viewing Room: Sunshine/Rainbow/Twilight
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Structural and Mechanistic Insights into Neutral ization Room: Storm Peak/Mt. Werner Speaker 1 of 8 * Ian A. Wilson, The Scripps Research Institute, USA
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Structural and Mechanistic Insights into Neutral ization Room: Storm Peak/Mt. Werner Speaker 2 of 8 Kimmo Rantalainen, The Scripps Research Institute, USA Structure of Full-Length HIV Envelope in Complex with PGT151
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Structural and Mechanistic Insights into Neutral ization Room: Storm Peak/Mt. Werner Speaker 3 of 8 Raiees Andrabi, The Scripps Research Institute, USA Glycans as Anchors for Inducing HIV Broadly Neutralizing Antibodies
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Structural and Mechanistic Insights into Neutral ization Room: Storm Peak/Mt. Werner Speaker 4 of 8 Sasha Murrell, The Scripps Research Institute, USA Structural Investigation of A Novel Family of Broadly Neutralizing Antibodies that Target the N332 Supersite in HIV Env
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Structural and Mechanistic Insights into Neutral ization Room: Storm Peak/Mt. Werner Speaker 5 of 8 Evan M. Cale, NIAID, National Institutes of Health, USA Isolation of an HIV-1-Specific Neutralizing Antibody Lineage with Similar Characteristics to the gp41-gp120 Interface-Binding Antibody 35O22
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Structural and Mechanistic Insights into Neutral ization Room: Storm Peak/Mt. Werner Speaker 6 of 8 Gwo-Yu Chuang, NIAID, National Institutes of Health, USA Optimization of HIV-1 Broadly Neutralizing Antibodies by Surface-Matrix Scanning
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Structural and Mechanistic Insights into Neutral ization Room: Storm Peak/Mt. Werner Speaker 7 of 8 Till Schoofs, Rockefeller University, USA Antibody 10-1074 Suppresses Viremia in HIV-1 Infected Individuals
Monday, March 27 \| 2:30PM - 4:30PM Workshop 1: Structural and Mechanistic Insights into Neutral ization Room: Storm Peak/Mt. Werner Speaker 8 of 8 Ryan Meyerhoff, Duke University, USA Induction of Antibodies Targeting the V3 Glycan Broadly Neutralizing Epitope in Rhesus Macaques using a Synthetic Immunogen
Monday, March 27 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Monday, March 27 \| 5:00PM - 7:15PM Lessons from Animal Vaccinations Room: Storm Peak/Mt. Werner Speaker 1 of 6 * Rogier W. Sanders, University of Amsterdam and Weill Cornell Medical College, Netherlands
Monday, March 27 \| 5:00PM - 7:15PM Lessons from Animal Vaccinations Room: Storm Peak/Mt. Werner Speaker 2 of 6 Paul Kellam, Kymab, UK Mice with Fully Human Immunoglobulin Loci and their Use for Predictive Vaccine Antigen Discovery
Monday, March 27 \| 5:00PM - 7:15PM Lessons from Animal Vaccinations Room: Storm Peak/Mt. Werner Speaker 3 of 6 Maria Blasi, Duke University School of Medicine, USA Short Talk: Sequential Immunizations with an Integrase Defective LentiVector Induce Higher Magnitude and More Durable Antibody Responses than DNA and Protein Based Vaccine Regimens
Monday, March 27 \| 5:00PM - 7:15PM Lessons from Animal Vaccinations Room: Storm Peak/Mt. Werner Speaker 4 of 6 Nancy L. Haigwood, Oregon Health & Science University, USA Passive and Active Studies in Primate Models to Inform HIV Vaccines
Monday, March 27 \| 5:00PM - 7:15PM Lessons from Animal Vaccinations Room: Storm Peak/Mt. Werner Speaker 5 of 6 Peter D. Kwong, NIAID, National Institutes of Health, USA Short Talk: Peptide-Coupled Carrier Proteins to Focus the Immune Response to an HIV-1 Site of Vulnerability
Monday, March 27 \| 5:00PM - 7:15PM Lessons from Animal Vaccinations Room: Storm Peak/Mt. Werner Speaker 6 of 6 Andrew B. Ward, The Scripps Research Institute, USA Structures of HIV Neutralizing Antibodies Elicited from Animal Immunization with SOSIP Env Trimers
Monday, March 27 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Foyer/Rainbow/Twilight No registration fees are used to fund alcohol served at this function.
Monday, March 27 \| 7:30PM - 10:00PM Poster Session 1 Room: Sunshine/Rainbow/Twilight
Tuesday, March 28 \| 7:00AM - 8:00AM Breakfast Room: Foyer/Rainbow/Twilight
Tuesday, March 28 \| 8:00AM - 11:15AM B and T Cells Room: Storm Peak/Mt. Werner Speaker 1 of 8 * Barton F. Haynes, Duke University Medical Center, USA
Tuesday, March 28 \| 8:00AM - 11:15AM B and T Cells Room: Storm Peak/Mt. Werner Speaker 2 of 8 Gunilla B. Karlsson Hedestam, Karolinska Institutet, Sweden Individualized Profiling of Germline V Genes and Application to Env Trimer Immunogenicity Studies in NHPs
Tuesday, March 28 \| 8:00AM - 11:15AM B and T Cells Room: Storm Peak/Mt. Werner Speaker 3 of 8 Thomas B. Kepler, Boston University, USA B Cell Clonal Dynamics during Sequential Immunizations
Tuesday, March 28 \| 8:00AM - 11:15AM B and T Cells Room: Storm Peak/Mt. Werner Speaker 4 of 8 Sabrina Helmold, NCI, National Institutes of Health, USA Short Talk:Dynamics of T Follicular Helper Cells and Germinal Center B Cells over the Course of Vaccination in Rhesus Macaques
Tuesday, March 28 \| 8:00AM - 11:15AM B and T Cells Room: Storm Peak/Mt. Werner Coffee Break
Tuesday, March 28 \| 8:00AM - 11:15AM B and T Cells Room: Storm Peak/Mt. Werner Speaker 6 of 8 Stephen J. Kent, University of Melbourne, Australia ADCC and Beyond
Tuesday, March 28 \| 8:00AM - 11:15AM B and T Cells Room: Storm Peak/Mt. Werner Speaker 7 of 8 Colin Havenar-Daughton, Vir Biotechnology, USA Short Talk: Germinal Centers Correlate with HIV Trimer-Induced Neutralizing Antibody Induction and Inform Improved Immunization Scheduling for Maximizing HIV Neutralizing Antibody Responses
Tuesday, March 28 \| 8:00AM - 11:15AM B and T Cells Room: Storm Peak/Mt. Werner Speaker 8 of 8 Marie Pancera, Fred Hutchinson Cancer Research Center, USA Short Talk: Anti-Idiotypic Antibodies against Inferred Germline b12, a CD4 Binding Site Antibody, as Toosl for Detection of Naïve B Cells Expressing Germline b12-like Precursors and Rational Immunogen Design
Tuesday, March 28 \| 11:15AM - 5:00PM On Own for Lunch
Tuesday, March 28 \| 11:15AM - 1:00PM Poster Setup Room: Sunshine/Rainbow/Twilight
Tuesday, March 28 \| 11:30AM - 1:00PM Hands-On Computer Session on Los Alamos Sequence Database Room: Skyline HIV Database Workshop presented by Los Alamos National Laboratory staff Topics include: - HIV Sequence Database - Bioinformatics tools that have general application Users can register for either or both workshops. Bring your own laptop.
Tuesday, March 28 \| 1:00PM - 10:00PM Poster Viewing Room: Sunshine/Rainbow/Twilight
Tuesday, March 28 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Tuesday, March 28 \| 5:00PM - 7:00PM Adjuvants and Delivery Systems Room: Storm Peak/Mt. Werner Speaker 1 of 5 * Robin Shattock, Imperial College London, UK
Tuesday, March 28 \| 5:00PM - 7:00PM Adjuvants and Delivery Systems Room: Storm Peak/Mt. Werner Speaker 2 of 5 Carl R. Alving, Walter Reed Army Institute of Research, USA Rational Basis for Creation and Selection of Adjuvant Formulations for HIV-1 Vaccines
Tuesday, March 28 \| 5:00PM - 7:00PM Adjuvants and Delivery Systems Room: Storm Peak/Mt. Werner Speaker 3 of 5 Mark T. Orr, Infectious Disease Research Institute, USA Tailoring Vaccine Responses with Formulated TLR Agonist Adjuvants
Tuesday, March 28 \| 5:00PM - 7:00PM Adjuvants and Delivery Systems Room: Storm Peak/Mt. Werner Speaker 4 of 5 James J. Kobie, University of Rochester, Medical Center, USA Short Talk: IL-33 Enhances the Induction, Durability, and Breadth of the Antibody Response to a DNA/Protein-Based HIV Env Vaccine
Tuesday, March 28 \| 5:00PM - 7:00PM Adjuvants and Delivery Systems Room: Storm Peak/Mt. Werner Speaker 5 of 5 Darrell J. Irvine, Massachusetts Institute of Technology, USA Regulation of the Germinal Center Reaction and Humoral Response by Vaccine Kinetics
Tuesday, March 28 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Foyer/Rainbow/Twilight No registration fees are used to fund alcohol served at this function.
Tuesday, March 28 \| 7:30PM - 10:00PM Poster Session 2 Room: Sunshine/Rainbow/Twilight
Wednesday, March 29 \| 7:00AM - 8:00AM Breakfast Room: Foyer/Rainbow/Twilight
Wednesday, March 29 \| 8:00AM - 11:15AM Human Clinical Trials Room: Storm Peak/Mt. Werner Speaker 1 of 8 * Gabriella Scarlatti, Global HIV Vaccine Enterprise, USA
Wednesday, March 29 \| 8:00AM - 11:15AM Human Clinical Trials Room: Storm Peak/Mt. Werner Speaker 2 of 8 Mark B. Feinberg, IAVI International AIDS Vaccine Initiative, USA Expediting Ebola Vaccine Development and Implications for HIV Vaccine R&D Efforts
Wednesday, March 29 \| 8:00AM - 11:15AM Human Clinical Trials Room: Storm Peak/Mt. Werner Speaker 3 of 8 Alberto Cagigi, NIAID, National Institutes of Health, USA Short Talk: Potential for Immunization with eOD-GT8 to Drive B Cell Responses Toward the Production of CD4bs Antibodies
Wednesday, March 29 \| 8:00AM - 11:15AM Human Clinical Trials Room: Storm Peak/Mt. Werner Speaker 4 of 8 Barton F. Haynes, Duke University Medical Center, USA Testing the Concept of B Cell Lineage Immunogen Design for Initiation of Broadly Neutralizing B Cell Lineages in Human Clinical Trials
Wednesday, March 29 \| 8:00AM - 11:15AM Human Clinical Trials Room: Storm Peak/Mt. Werner Coffee Break
Wednesday, March 29 \| 8:00AM - 11:15AM Human Clinical Trials Room: Storm Peak/Mt. Werner Speaker 6 of 8 Kelly E. Seaton, Duke Human Vaccine Institute, USA Short Talk: Individual-level meta-analysis of HIV-1 Vaccine Elicited Mucosal Antibodies in Human Volunteers
Wednesday, March 29 \| 8:00AM - 11:15AM Human Clinical Trials Room: Storm Peak/Mt. Werner Speaker 7 of 8 M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA Induction of HIV-Specific Immunity with Recent Clinical Vaccine Approaches
Wednesday, March 29 \| 8:00AM - 11:15AM Human Clinical Trials Room: Storm Peak/Mt. Werner Speaker 8 of 8 Robin Shattock, Imperial College London, UK DNA Vaccination for Experimental Medicine Trials of HIV Vaccines
Wednesday, March 29 \| 11:15AM - 5:00PM On Own for Lunch
Wednesday, March 29 \| 11:15AM - 1:00PM Poster Setup Room: Sunshine/Rainbow/Twilight
Wednesday, March 29 \| 11:30AM - 1:00PM Hands-On Computer Session on Los Alamos Immunology Database Room: Skyline HIV Database Workshop presented by Los Alamos National Laboratory staff Topics include: - HIV Immunology Database - Immunology and vaccine design tools that have general application.
Wednesday, March 29 \| 1:00PM - 10:00PM Poster Viewing Room: Sunshine/Rainbow/Twilight
Wednesday, March 29 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Wednesday, March 29 \| 5:00PM - 7:00PM Lessons from Infection Room: Storm Peak/Mt. Werner Speaker 1 of 5 * Penny L. Moore, University of the Witwatersrand and National Institute for Communicable Diseases, South Africa
Wednesday, March 29 \| 5:00PM - 7:00PM Lessons from Infection Room: Storm Peak/Mt. Werner Speaker 2 of 5 Thumbi Ndung'u, University of KwaZulu-Natal, South Africa Antiretroviral Treatment of Acute HIV Infection and the Prospect for a Functional Cure
Wednesday, March 29 \| 5:00PM - 7:00PM Lessons from Infection Room: Storm Peak/Mt. Werner Speaker 3 of 5 Christiane Moog, INSERM and Université of Strasbourg, France Short Talk: Unexpected Antibody Isotypes and Neutralizing Profile in Patients Controlling HIV
Wednesday, March 29 \| 5:00PM - 7:00PM Lessons from Infection Room: Storm Peak/Mt. Werner Speaker 4 of 5 Julie M. Overbaugh, Fred Hutchinson Cancer Research Center, USA Unique Aspects of the Infant HIV-Specific Neutralizing Antibody Response
Wednesday, March 29 \| 5:00PM - 7:00PM Lessons from Infection Room: Storm Peak/Mt. Werner Speaker 5 of 5 Alexandra Trkola, University of Zürich, Switzerland Determinants of bnAb Development
Wednesday, March 29 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Foyer/Rainbow/Twilight No registration fees are used to fund alcohol served at this function.
Wednesday, March 29 \| 7:30PM - 10:00PM Poster Session 3 Room: Sunshine/Rainbow/Twilight
Thursday, March 30 \| 7:00AM - 8:00AM Breakfast Room: Foyer/Rainbow/Twilight
Thursday, March 30 \| 8:00AM - 11:15AM Broadly Neutralizing Antibodies: Hurdles and Opportunities Room: Storm Peak/Mt. Werner Speaker 1 of 9 * Alexandra Trkola, University of Zürich, Switzerland
Thursday, March 30 \| 8:00AM - 11:15AM Broadly Neutralizing Antibodies: Hurdles and Opportunities Room: Storm Peak/Mt. Werner Speaker 2 of 9 Penny L. Moore, University of the Witwatersrand and National Institute for Communicable Diseases, South Africa Longitudinal Studies of Neutralizing Antibody Development in the CAPRISA Cohort
Thursday, March 30 \| 8:00AM - 11:15AM Broadly Neutralizing Antibodies: Hurdles and Opportunities Room: Storm Peak/Mt. Werner Speaker 3 of 9 Kshitij Wagh, Los Alamos National Laboratory, USA Short Talk: Env Glycan Holes Negatively Impact Development of Heterologous Neutralization Breadth in HIV-1 Infections
Thursday, March 30 \| 8:00AM - 11:15AM Broadly Neutralizing Antibodies: Hurdles and Opportunities Room: Storm Peak/Mt. Werner Speaker 4 of 9 Brandon DeKosky, University of Kansas, USA Short Talk: High-Throughput Paired Heavy and Light Chain Analyses of HIV Broadly Neutralizing Antibody Lineages
Thursday, March 30 \| 8:00AM - 11:15AM Broadly Neutralizing Antibodies: Hurdles and Opportunities Room: Storm Peak/Mt. Werner Coffee Break
Thursday, March 30 \| 8:00AM - 11:15AM Broadly Neutralizing Antibodies: Hurdles and Opportunities Room: Storm Peak/Mt. Werner Speaker 6 of 9 Elise Landais, International AIDS Vaccine Initiative, USA Broadly Neutralizing Antibodies to HIV-1: Lessons from Protocol C Studies
Thursday, March 30 \| 8:00AM - 11:15AM Broadly Neutralizing Antibodies: Hurdles and Opportunities Room: Storm Peak/Mt. Werner Speaker 7 of 9 Wilton B. Williams, Duke University, USA Short Talk: SHIV-CH505 Infection of Rhesus macaques Recapitulates HIV-1 Env-Antibody Evolution in Humans
Thursday, March 30 \| 8:00AM - 11:15AM Broadly Neutralizing Antibodies: Hurdles and Opportunities Room: Storm Peak/Mt. Werner Speaker 8 of 9 Samantha Leigh Grimley, San Diego Biomedical Research Institute, USA Short Talk: Striking Impact of HIV-1 Envelope Glycoengineering on BnAb Sensitivities
Thursday, March 30 \| 8:00AM - 11:15AM Broadly Neutralizing Antibodies: Hurdles and Opportunities Room: Storm Peak/Mt. Werner Speaker 9 of 9 Nicole A. Doria-Rose, NIAID, National Institutes of Health, USA Tracing Virus-Antibody Co-Evolution of MPER-directed Neutralizing Antibodies
Thursday, March 30 \| 11:15AM - 5:00PM On Own for Lunch
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Testing Vaccine Platforms in Animals Room: Storm Peak/Mt. Werner Speaker 1 of 8 * Richard T. Wyatt, IAVI Neutralizing Antibody Center, The Scripps Research Institute, USA
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Testing Vaccine Platforms in Animals Room: Storm Peak/Mt. Werner Speaker 2 of 8 Diane L. Bolton, US Military HIV Research Program, WRAIR, USA Immunogenicity and Efficacy of MVA, gp145 Vaccination Against Heterologous Tier 2 SHIV C Challenge in Rhesus
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Testing Vaccine Platforms in Animals Room: Storm Peak/Mt. Werner Speaker 3 of 8 Qifeng Han, Duke University, USA HIV gp41 Immunodominance Following gp140 Immunization Occurs in Humans but is Not Detected in Rhesus Macaques
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Testing Vaccine Platforms in Animals Room: Storm Peak/Mt. Werner Speaker 4 of 8 Mattias Forsell, Umeå University, Sweden Autologous But Not Heterologous Antibodies Negatively Regulate Subunit-Specific Germinal Center B Cell Responses to the HIV-1 Envelope Glycoproteins
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Testing Vaccine Platforms in Animals Room: Storm Peak/Mt. Werner Speaker 5 of 8 Matthias Georg Pauthner, The Scripps Research Institute, USA Optimized Env Trimer Immunization Parameters Amplify Onset, Magnitude and Consistency of Autologous Tier 2 Neutralizing Antibody Development in Nonhuman Primates
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Testing Vaccine Platforms in Animals Room: Storm Peak/Mt. Werner Speaker 6 of 8 Paola Andrea Martinez Murillo, Karolinska Institutet, Sweden F9, A New Class of Antibody that Neutralizes Autologous Tier 2 Viruses in Rhesus Immunized with Liposome Conjugated Well-Ordered Trimers
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Testing Vaccine Platforms in Animals Room: Storm Peak/Mt. Werner Speaker 7 of 8 Jose Maximiliano Medina-Ramírez, University of Amsterdam, Netherlands A Native-Like Envelope Trimer with Enhanced Binding of Inferred Germline Precursors of Broadly Neutralizing HIV-1 Antibodies
Thursday, March 30 \| 2:30PM - 4:30PM Workshop 2: Testing Vaccine Platforms in Animals Room: Storm Peak/Mt. Werner Speaker 8 of 8 James E. Voss, The Scripps Research Institute, USA Reproducible Elicitation of HIV Envelope V2-Apex Focused Neutralizing Antibodies in Rabbits
Thursday, March 30 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Thursday, March 30 \| 5:00PM - 6:45PM Immunogen Platforms Room: Storm Peak/Mt. Werner Speaker 1 of 4 * Peter D. Kwong, NIAID, National Institutes of Health, USA
Thursday, March 30 \| 5:00PM - 6:45PM Immunogen Platforms Room: Storm Peak/Mt. Werner Speaker 2 of 4 Jon Steichen, The Scripps Research Institute, USA HIV Vaccine Design to Target Germline Precursors of N332-Dependent Broadly Neutralizing Antibodies
Thursday, March 30 \| 5:00PM - 6:45PM Immunogen Platforms Room: Storm Peak/Mt. Werner Speaker 3 of 4 Neil P. King, University of Washington, USA Design of Novel Self-Assembling Protein Nanomaterials as Next-Generation Vaccine Scaffolds
Thursday, March 30 \| 5:00PM - 6:45PM Immunogen Platforms Room: Storm Peak/Mt. Werner Speaker 4 of 4 Rogier W. Sanders, University of Amsterdam and Weill Cornell Medical College, Netherlands Inducing HIV-1 Neutralizing Antibodies with Native-Like Envelope Trimers
Thursday, March 30 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Storm Peak/Mt. Werner
Thursday, March 30 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Foyer/Rainbow/Twilight No registration fees are used to fund alcohol served at this function.
Thursday, March 30 \| 8:00PM - 11:00PM Entertainment Room: Sunshine Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Thursday, March 30 \| 8:00PM - 11:00PM Cash Bar Room: Sunshine
Friday, March 31 \| 10:25AM - 10:25AM Departure *Session Chair.