Web Desc
Immune Regulation in Autoimmunity and Cancer
Organizer(s): David A. Hafler, Vijay K. Kuchroo and Jane L. Grogan
Date: March 26 - 30, 2017
Location: Whistler Conference Centre, Whistler, BC, Canada
Sponsored by Abide Therapeutics Inc., BioLegend, Inc., Genentech, Inc., Juno Therapeutics, MorphoSys AG, OncoMed Pharmaceuticals, Inc., Pfizer Inc. and Roche. This activity was supported by an educational grant from Celgene Corporation.
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Summary of Meeting:
While the importance of adoptive and innate immunity has been clear in the pathogenesis of human autoimmune disease resulting in a multitude of immune-based therapeutic approaches, the realization is now apparent that understanding immune evasion by cancer is central in developing curative treatments. This meeting will explore and contrast the underlying immune mechanisms resulting in autoimmunity and tumor evasion. The meeting is innovative in bringing together basic immunologists investigating mechanisms of tolerance with scientists exploring immune mechanisms of autoimmunity and cancer in both patients and experimental models. Thus, this Keystone Symposia meeting will cover the pathways in immunity and tolerance that lead to loss of immunological control, dysregulated immune responses and chronic inflammatory disease or tumor evasion. Presentations will include consideration of preclinical and clinical aspects of a diverse number of autoimmune and inflammatory diseases and cancer. Conference participants engaged in preclinical, translational and clinical research will hopefully engage in continuing conversations and collaborations which, over the long-term, will provide greater insights into the human immune response and allow us to reassess and further explore pathways that are driving autoimmune disease yet in opposition, lead to tumor evasion. Understanding checkpoints in autoimmunity and immune cell tolerance is important for delivering therapies to patients with autoimmune disease and cancer, and this meeting will provide a platform for the cross-pollination of clinical experience and experimental research. Attendees will have learned about the impact of targeted immune-based therapeutics on clinical outcome and, consequently, be able to widen their research scope accordingly.
Scholarship Deadline: November 29 2016
Discounted Abstract Deadline: November 29 2016
Abstract Deadline: January 10 2017
Discounted Registration Deadline: January 25 2017
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Abide Therapeutics Inc.BioLegend, Inc.This activity was supported by an educational grant from Celgene CorporationGenentech, Inc.Juno TherapeuticsMorphoSys AGOncoMed Pharmaceuticals, Inc.Pfizer Inc.Roche
We gratefully acknowledge additional support for this conference from:
CEDARLANE
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

Novartis Institutes for BioMedical Research
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
BioMed Central Ltd
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 26 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Foyer


Sunday, March 26 | 6:00PM - 8:00PM
Welcome Mixer
Room: Grand Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky B


Monday, March 27 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky C

Speaker 1 of 2
* David A. Hafler, Yale University School of Medicine, USA

Monday, March 27 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky C

Speaker 2 of 2
James P. Allison, University of Texas MD Anderson Cancer Center, USA
Cancer Immunotherapy

Monday, March 27 | 9:00AM - 11:15AM
Tissue Micro-Immune Environments in Tumors and Autoimmune Ti
ssue Inflammation

Room: Sea to Sky C

Speaker 1 of 5
Padmanee Sharma, University of Texas MD Anderson Cancer Center, USA
From the Clinic to the Lab: Investigating Response and Resistance Mechanisms to Immune Checkpoint Therapy

Monday, March 27 | 9:00AM - 11:15AM
Tissue Micro-Immune Environments in Tumors and Autoimmune Ti
ssue Inflammation

Room: Sea to Sky C


Coffee Break

Monday, March 27 | 9:00AM - 11:15AM
Tissue Micro-Immune Environments in Tumors and Autoimmune Ti
ssue Inflammation

Room: Sea to Sky C

Speaker 3 of 5
Jennifer L. Gommerman, University of Toronto, Canada
Compartmentalization of B Cells During CNS Inflammation

Monday, March 27 | 9:00AM - 11:15AM
Tissue Micro-Immune Environments in Tumors and Autoimmune Ti
ssue Inflammation

Room: Sea to Sky C

Speaker 4 of 5
* Jane L. Grogan, Arsenal Biosciences, USA
Immunoregulatory Roles of TIGIT and PVR-nectin Family in Tumors

Monday, March 27 | 9:00AM - 11:15AM
Tissue Micro-Immune Environments in Tumors and Autoimmune Ti
ssue Inflammation

Room: Sea to Sky C

Speaker 5 of 5
Abigail E. Overacre-Delgoffe, University of Pittsburgh, USA
Short Talk: Interferon-gamma drives Treg Functional Instability thereby Promoting Anti-Tumor Immunity

Monday, March 27 | 11:15AM - 5:00PM
On Own for Lunch


Monday, March 27 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky B


Monday, March 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky B


Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Effector T Cells
Room: Sea to Sky C

Speaker 1 of 10
* Thomas Korn, Technical University Munich, Germany

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Effector T Cells
Room: Sea to Sky C

Speaker 2 of 10
* Jane L. Grogan, Arsenal Biosciences, USA

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Effector T Cells
Room: Sea to Sky C

Speaker 3 of 10
June-Yong Lee, New York University School of Medicine, USA
Systemic and Local Functions of Serum Amyloid A (SAA) in Th17 Cell Pathogenicity

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Effector T Cells
Room: Sea to Sky C

Speaker 4 of 10
Jinju Lee, Kyoto University Graduate School of Medicine, Japan
Regulation of Th17 Expansion by PGE2-EP2/EP4 Signaling and its Clinical Implication

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Effector T Cells
Room: Sea to Sky C

Speaker 5 of 10
Pradip Nair, Biocon Research Limited, India
T Cell Activation and Differentiation to Th17 Cells is Modulated by a CD6 Domain 1 Antibody Itolizumab

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Effector T Cells
Room: Sea to Sky C

Speaker 6 of 10
Patricia Castillo, University of Pittsburgh, USA
Disrupted Enteric Th17 Signaling Exacerbates Autoimmune Inflammation

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Effector T Cells
Room: Sea to Sky C

Speaker 7 of 10
Michael Waterfield, University of California, San Francisco, USA
Characterization of a Novel Epigenetic Regulator Required for Th17 Differentiation

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Effector T Cells
Room: Sea to Sky C

Speaker 8 of 10
Mark S. Sundrud, The Scripps Research Institute, USA
The Xenobiotic Transporter Mdr1 Permits T Cell Adaptation to Mucosa-Associated Bile Acids in the Ileum

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Effector T Cells
Room: Sea to Sky C

Speaker 9 of 10
Geoffrey Alexander Smith, University of California, San Francisco, USA
IL-2RB Receptor Levels Tune T-Cell IL-2 Responses by Altering Signaling Dynamics in Different T Cell Subsets

Monday, March 27 | 2:30PM - 4:30PM
Workshop 1: Effector T Cells
Room: Sea to Sky C

Speaker 10 of 10
Peter A. Morawski, NIAID, National Institutes of Health, USA
Brain Infiltrating CD8+ T Cells in Lupus-Prone Mice

Monday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Monday, March 27 | 5:00PM - 7:00PM
Basic Mechanisms of T Cell Tolerance
Room: Sea to Sky C

Speaker 1 of 3
* Jeffrey A. Bluestone, University of California, San Francisco, USA
Treg Biology and Treatment in Autoimmune Diseases and Cancer

Monday, March 27 | 5:00PM - 7:00PM
Basic Mechanisms of T Cell Tolerance
Room: Sea to Sky C

Speaker 2 of 3
David A. Hafler, Yale University School of Medicine, USA
IFNgamma Identifies Dysfunctional Regulatory T Cells in Autoimmunity and Cancer

Monday, March 27 | 5:00PM - 7:00PM
Basic Mechanisms of T Cell Tolerance
Room: Sea to Sky C

Speaker 3 of 3
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Regulatory T Cells in Cancer

Monday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky B
No registration fees are used to fund alcohol served at this function.

Monday, March 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky B


Tuesday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky B


Tuesday, March 28 | 8:00AM - 11:00AM
Metabolic Regulation of T Cell Function in Cancer and Autoim
munity

Room: Sea to Sky C

Speaker 1 of 6
* Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
How Metabolism Influences CD8 Cells in Cancer

Tuesday, March 28 | 8:00AM - 11:00AM
Metabolic Regulation of T Cell Function in Cancer and Autoim
munity

Room: Sea to Sky C

Speaker 2 of 6
Douglas R. Green, St. Jude Children's Research Hospital, USA
Cell Death and Resuscitation: To the Edge of Necroptosis and Back

Tuesday, March 28 | 8:00AM - 11:00AM
Metabolic Regulation of T Cell Function in Cancer and Autoim
munity

Room: Sea to Sky C


Coffee Break

Tuesday, March 28 | 8:00AM - 11:00AM
Metabolic Regulation of T Cell Function in Cancer and Autoim
munity

Room: Sea to Sky C

Speaker 4 of 6
Jens Titze, Vanderbilt University, USA
Rethinking Sodium Metabolism

Tuesday, March 28 | 8:00AM - 11:00AM
Metabolic Regulation of T Cell Function in Cancer and Autoim
munity

Room: Sea to Sky C

Speaker 5 of 6
Tomokazu Sumida, Yale School of Medicine, USA
Short Talk: Beta-catenin Links High Salt and Proinflammatory Signature in Treg

Tuesday, March 28 | 8:00AM - 11:00AM
Metabolic Regulation of T Cell Function in Cancer and Autoim
munity

Room: Sea to Sky C

Speaker 6 of 6
Seungho Lee, Yonsei University, South Korea
Short Talk: Exploration of Tumor Microenvironment and Metabolism using Tumor Infiltrating Lymphocytes and FDG-PET CT

Tuesday, March 28 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, March 28 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky B


Tuesday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky B


Tuesday, March 28 | 2:30PM - 4:30PM
Workshop 2: Tregs in Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 1 of 10
* Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA

Tuesday, March 28 | 2:30PM - 4:30PM
Workshop 2: Tregs in Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 2 of 10
* Ana Carrizosa Anderson, Harvard Medical School, USA

Tuesday, March 28 | 2:30PM - 4:30PM
Workshop 2: Tregs in Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 3 of 10
Liliana Elisa Lucca, Yale University, USA
PD-1 Marks Dysfunctional Regulatory T Cells in Malignant Gliomas

Tuesday, March 28 | 2:30PM - 4:30PM
Workshop 2: Tregs in Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 4 of 10
Maran L. Sprouse, Baylor College of Medicine, USA
High CD5 Expression is a Marker of Functional Regulatory T Cells in Autoimmunity

Tuesday, March 28 | 2:30PM - 4:30PM
Workshop 2: Tregs in Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 5 of 10
Catherine Konopacki, Memorial Sloan Kettering Cancer Center, USA
Foxp1 Is a Foxp3 Binding Partner that Contributes to Regulatory T Cell Stability and Function

Tuesday, March 28 | 2:30PM - 4:30PM
Workshop 2: Tregs in Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 6 of 10
Allison L. Bayer, University of Miami School of Medicine, USA
Immunomodulation Requirements for Treg Immunotherapy for Autoimmune Diabetes

Tuesday, March 28 | 2:30PM - 4:30PM
Workshop 2: Tregs in Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 7 of 10
Danbee Ha, Osaka University, Japan
ADCC-Mediated in vitro Depletion of Human Treg Cells by Anti-CTLA-4 mAb Enhances CD8+ T Cell Responses against Self/Tumor Antigens

Tuesday, March 28 | 2:30PM - 4:30PM
Workshop 2: Tregs in Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 8 of 10
David Bauche, Merck, USA
Foxp3+ Regulatory T Cells Prevent from ILC3-Driven Colitis

Tuesday, March 28 | 2:30PM - 4:30PM
Workshop 2: Tregs in Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 9 of 10
Wenxian Fu, University of California, San Diego, USA
A Tissue-Resident Macrophage Specific Coinhibitory Molecule Promotes Regulatory T Cell Differentiation and Stability

Tuesday, March 28 | 2:30PM - 4:30PM
Workshop 2: Tregs in Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 10 of 10
Dana Catherine Gilmore, University of Chicago, USA
Identification of Natural Peptide Epitopes Recognized by Regulatory T Cells

Tuesday, March 28 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Tuesday, March 28 | 5:00PM - 7:00PM
Effector T Cell Dysfunction: Surface Receptors in Autoimmuni
ty vs. Cancer

Room: Sea to Sky C

Speaker 1 of 4
* Arlene H. Sharpe, Harvard Medical School, USA
Role of Coinhibitory Receptors in Controlling Effector T Cells

Tuesday, March 28 | 5:00PM - 7:00PM
Effector T Cell Dysfunction: Surface Receptors in Autoimmuni
ty vs. Cancer

Room: Sea to Sky C

Speaker 2 of 4
E. John Wherry, University of Pennsylvania, USA
Molecular Basis of T Cell Exhaustion: Insights for Immunotherapy

Tuesday, March 28 | 5:00PM - 7:00PM
Effector T Cell Dysfunction: Surface Receptors in Autoimmuni
ty vs. Cancer

Room: Sea to Sky C

Speaker 3 of 4
Ana Carrizosa Anderson, Harvard Medical School, USA
T Cell Dysfunction: From Co-Inhibitory Receptors to Molecular Programs

Tuesday, March 28 | 5:00PM - 7:00PM
Effector T Cell Dysfunction: Surface Receptors in Autoimmuni
ty vs. Cancer

Room: Sea to Sky C

Speaker 4 of 4
Christopher E. Rudd, University of Montreal, Canada
Short Talk: A Next Generation Approach using Small Molecules to Inhibit PD-1 Transcription Is as Effective as Anti-PD-1/PL1 Biologics in Immunotherapy

Tuesday, March 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky B
No registration fees are used to fund alcohol served at this function.

Tuesday, March 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky B


Wednesday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky B


Wednesday, March 29 | 8:00AM - 11:00AM
Innate Regulation of Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 1 of 6
Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA
Role of Dendritic Cells and NK Cells in Mediating Anti-Tumor Responses

Wednesday, March 29 | 8:00AM - 11:00AM
Innate Regulation of Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 2 of 6
Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Autoreactive T Cells in Narcoleptic Patients

Wednesday, March 29 | 8:00AM - 11:00AM
Innate Regulation of Autoimmunity and Cancer
Room: Sea to Sky C


Coffee Break

Wednesday, March 29 | 8:00AM - 11:00AM
Innate Regulation of Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 4 of 6
* Carla V. Rothlin, Yale University, USA
Innate Immune Checkpoints in Anti-Tumor Immunity

Wednesday, March 29 | 8:00AM - 11:00AM
Innate Regulation of Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 5 of 6
Mark J. Smyth, QIMR Berghofer Medical Research Institute, Australia
Barriers to NK Cell Control of Cancer

Wednesday, March 29 | 8:00AM - 11:00AM
Innate Regulation of Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 6 of 6
Keiji Hirota, Kyoto University, Japan
Short Talk: An Inflammatory Cellular Network of Autoimmune Th17 Cells, GM-CSF-Producing ILCs and Synoviocytes in the
Development of Autoimmune Arthritis


Wednesday, March 29 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, March 29 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky B


Wednesday, March 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky B


Wednesday, March 29 | 2:30PM - 4:30PM
Workshop 3: T Cell Tolerance, Exhaustion and Dysfunction in
Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 1 of 8
* Kenneth Smith, University of Cambridge, UK

Wednesday, March 29 | 2:30PM - 4:30PM
Workshop 3: T Cell Tolerance, Exhaustion and Dysfunction in
Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 2 of 8
Rachel S. Friedman, National Jewish Health and University of Colorado Denver, USA
MerTK Mediates T Cell Tolerance in the Pancreatic Islets during Type 1 Diabetes

Wednesday, March 29 | 2:30PM - 4:30PM
Workshop 3: T Cell Tolerance, Exhaustion and Dysfunction in
Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 3 of 8
Yemsratch T. Akalu, Yale University School of Medicine, USA
An eMERging Target in Cancer Immunotherapy

Wednesday, March 29 | 2:30PM - 4:30PM
Workshop 3: T Cell Tolerance, Exhaustion and Dysfunction in
Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 4 of 8
Rachael Bashford-Rogers, University of Oxford, UK
Using High-Throughput Sequencing to Reveal Insights into the Relationship between B-Cell Repertoire, Phenotype and Function in Health, Cancer and Autoimmune Disease

Wednesday, March 29 | 2:30PM - 4:30PM
Workshop 3: T Cell Tolerance, Exhaustion and Dysfunction in
Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 5 of 8
David M. Sansom, University College London Medical School, UK
CTLA-4 Mutations from Patients with Immune Dysregulation Syndromes Inform our Understanding of CTLA-4 Function

Wednesday, March 29 | 2:30PM - 4:30PM
Workshop 3: T Cell Tolerance, Exhaustion and Dysfunction in
Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 6 of 8
Jennifer Lori Blanchfield, Emory University, USA
MOG-Specific Tolerance Mechanisms Limit Autoimmune Demyelinating Disease following Bacterial Delivery of MOG Epitope

Wednesday, March 29 | 2:30PM - 4:30PM
Workshop 3: T Cell Tolerance, Exhaustion and Dysfunction in
Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 7 of 8
John R. Sedy, Sanford Burnham Prebys Medical Discovery Institute, USA
Cancer Mutations Targeting TNFRSF14 alter Microenvironment Checkpoint Interactions to Limit Tumor Clearance by Cytotoxic Cells

Wednesday, March 29 | 2:30PM - 4:30PM
Workshop 3: T Cell Tolerance, Exhaustion and Dysfunction in
Autoimmunity and Cancer
Room: Sea to Sky C

Speaker 8 of 8
Greg M. Delgoffe, University of Pittsburgh, USA
Defects in Mitochondrial Biogenesis and Oxidative Function Underlie Tumor-Infiltrating T Dysfunction

Wednesday, March 29 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Wednesday, March 29 | 5:00PM - 7:00PM
B Cell Regulation of Autoimmunity
Room: Sea to Sky C

Speaker 1 of 4
* Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Mechanisms of Antibody Diversification

Wednesday, March 29 | 5:00PM - 7:00PM
B Cell Regulation of Autoimmunity
Room: Sea to Sky C

Speaker 2 of 4
Kenneth Smith, University of Cambridge, UK
Predicting and Explaining the Future: A New Biology of Clinical Outcome in Autoimmunity?

Wednesday, March 29 | 5:00PM - 7:00PM
B Cell Regulation of Autoimmunity
Room: Sea to Sky C

Speaker 3 of 4
Alicia Gonzalez-Martin, The Scripps Research Institute, USA
Short Talk: MicroRNA Control of B Cell Tolerance and Autoimmunity

Wednesday, March 29 | 5:00PM - 7:00PM
B Cell Regulation of Autoimmunity
Room: Sea to Sky C

Speaker 4 of 4
Bonnie Huang, NHGRI, National Institutes of Health, USA
Short Talk: Dissecting T Follicular Helper Cell Development in vivo using CRISPR

Wednesday, March 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky B
No registration fees are used to fund alcohol served at this function.

Wednesday, March 29 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky B


Thursday, March 30 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky B


Thursday, March 30 | 8:00AM - 11:15AM
Ten Years of Discovery of Th17 Cells: From Bench to Bedside
Room: Sea to Sky C

Speaker 1 of 6
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Transcriptional Networks in Development of Th17 Cells

Thursday, March 30 | 8:00AM - 11:15AM
Ten Years of Discovery of Th17 Cells: From Bench to Bedside
Room: Sea to Sky C

Speaker 2 of 6
Dan R. Littman, HHMI/New York University School of Medicine, USA
Th17 Cells in the Gut Homoeostasis

Thursday, March 30 | 8:00AM - 11:15AM
Ten Years of Discovery of Th17 Cells: From Bench to Bedside
Room: Sea to Sky C


Coffee Break

Thursday, March 30 | 8:00AM - 11:15AM
Ten Years of Discovery of Th17 Cells: From Bench to Bedside
Room: Sea to Sky C

Speaker 4 of 6
Thomas Korn, Technical University Munich, Germany
Trans-presentation of IL-6 by Dendritic Cells - A Novel Mode of IL-6 Signaling – Is Required for the Priming of Pathogenic TH17 Cells in vivo

Thursday, March 30 | 8:00AM - 11:15AM
Ten Years of Discovery of Th17 Cells: From Bench to Bedside
Room: Sea to Sky C

Speaker 5 of 6
Daniel J. Cua, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
The IL-23-Th17 Immune Axis: From Mechanisms to Therapeutic Testing

Thursday, March 30 | 8:00AM - 11:15AM
Ten Years of Discovery of Th17 Cells: From Bench to Bedside
Room: Sea to Sky C

Speaker 6 of 6
Dhavalkumar D. Patel, UCB S.A., Belgium
Therapeutic Targeting of Th17 Cells in Autoimmune Diseases

Thursday, March 30 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, March 30 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Thursday, March 30 | 5:00PM - 6:45PM
Systems Biology Approaches to Understanding Tolerance in Can
cer and Autoimmunity

Room: Sea to Sky C

Speaker 1 of 3
* Frank Oliver Nestle, Sanofi, USA
Deciphering the Rules of Engagement of Tissue Immunity

Thursday, March 30 | 5:00PM - 6:45PM
Systems Biology Approaches to Understanding Tolerance in Can
cer and Autoimmunity

Room: Sea to Sky C

Speaker 2 of 3
Alex Marson, University of California, San Francisco, USA
Decoding T Cell Circuitry

Thursday, March 30 | 5:00PM - 6:45PM
Systems Biology Approaches to Understanding Tolerance in Can
cer and Autoimmunity

Room: Sea to Sky C

Speaker 3 of 3
Meromit Singer, Broad Institute, USA
Short Talk: Identification and Validation of a Gene Module Specific for T Cell Dysfunction in Tumor via Population and Single-Cell Transcriptomics

Thursday, March 30 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Sea to Sky C


Thursday, March 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky B
No registration fees are used to fund alcohol served at this function.

Thursday, March 30 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky B
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 30 | 8:00PM - 11:00PM
Cash Bar
Room: Grand Foyer


Friday, March 31 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.