Web Desc
B Cells and T Follicular Helper Cells - Controlling Long-Lived Immunity
Organizer(s): Stuart G. Tangye, Ignacio Sanz and Hai Qi
Date: April 23 - 27, 2017
Location: Whistler Conference Centre, Whistler, BC, Canada
Sponsored by Arena Pharmaceuticals, Inc., BioLegend, Inc. and Merck & Co., Inc.
Summary of Meeting:
B cells are fundamental for the development of long-lived immunological memory following exposure to infectious pathogens and, consequently, for the success of the vast majority of currently-available vaccines. The differentiation of B cells into the effector cells of serological memory – memory B cells and plasma cells – occurs in germinal centers. However this process critically requires a specialized subset of CD4+ T cells termed T follicular helper (Tfh) cells. The integration of signals required to generate germinal center B cells, memory and plasma cells, and Tfh cells are strictly controlled. This is to ensure the efficient selection of antigen-specific high-affinity effector cells, and to prevent the development of immune dyscrasias associated with GCs, such as autoimmunity, immune deficiency and malignancy – conditions that can develop when the complexities of lymphocyte differentiation in germinal centers are dysregulated. Despite the substantial advances that have been made in understanding the cellular, biochemical and molecular requirements for the generation of effective T-dependent B-cell responses, major questions regarding these processes remain. Answers to such questions are needed so as to be able to harness the intrinsic function of memory B cells, plasma cells and Tfh cells in order to enhance immunity in immunocompromised individuals, improve vaccine design and develop novel vaccines for infectious pathogens, as well as to attenuate humoral immune responses in the setting of autoantibody-mediated autoimmune diseases. This meeting will bring together basic and clinical immunologists to address unanswered questions and to discuss the latest cutting-edge breakthroughs in the biology of B cells and Tfh cells to facilitate development of new translational strategies of regulating their behavior in human immunopathologies.
Scholarship Deadline: December 21 2016
Discounted Abstract Deadline: December 21 2016
Abstract Deadline: January 24 2017
Discounted Registration Deadline: February 23 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Arena Pharmaceuticals, Inc.BioLegend, Inc.Merck & Co., Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
American Association for the Advancement of Science (AAAS)
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI128965-01
Funding for this conference was made possible (in part) by AI 128965-01 from the National Institute of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 23 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Foyer


Sunday, April 23 | 6:00PM - 8:00PM
Welcome Mixer
Room: Grand Foyer
No registration fees are used to fund alcohol served at this function.

Monday, April 24 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Monday, April 24 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky B/C

Speaker 1 of 2
* Stuart G. Tangye, Garvan Institute of Medical Research, Australia

Monday, April 24 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky B/C

Speaker 2 of 2
Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Actively Acquired Tolerance in the Antibody System - The Iliad and The Odyssey

Monday, April 24 | 9:00AM - 11:00AM
B Cells, Infections and Vaccines
Room: Sea to Sky B/C

Speaker 1 of 6
* Hai Qi, Tsinghua University, China

Monday, April 24 | 9:00AM - 11:00AM
B Cells, Infections and Vaccines
Room: Sea to Sky B/C

Speaker 2 of 6
William Schief, International AIDS Vaccine Initiative and The Scripps Research Institute, USA
HIV Vaccine Strategies to Guide B Cell Maturation

Monday, April 24 | 9:00AM - 11:00AM
B Cells, Infections and Vaccines
Room: Sea to Sky B/C


Coffee Break

Monday, April 24 | 9:00AM - 11:00AM
B Cells, Infections and Vaccines
Room: Sea to Sky B/C

Speaker 4 of 6
Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Molecular Requirements for Generating Long-Lived Humoral Immunity in Humans: Lessons from Human Genetic Diseases

Monday, April 24 | 9:00AM - 11:00AM
B Cells, Infections and Vaccines
Room: Sea to Sky B/C

Speaker 5 of 6
Jenny L. Johnson, St. Jude Children's Research Hospital, USA
Short Talk: The Role of Germinal Centers in Generating Antibodies to Conserved Influenza Epitopes

Monday, April 24 | 9:00AM - 11:00AM
B Cells, Infections and Vaccines
Room: Sea to Sky B/C

Speaker 6 of 6
Deepak Rao, Brigham and Women's Hospital, USA
Short Talk: Plasticity of Circulating PD-1hi Follicular and Peripheral Helper T Cells

Monday, April 24 | 11:00AM - 5:00PM
On Own for Lunch


Monday, April 24 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Monday, April 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Monday, April 24 | 2:30PM - 4:30PM
Workshop 1: B Cell Memory and Plasma Cells
Room: Sea to Sky B/C

Speaker 1 of 10
* Kathryn A. Pape, University of Minnesota, USA

Monday, April 24 | 2:30PM - 4:30PM
Workshop 1: B Cell Memory and Plasma Cells
Room: Sea to Sky B/C

Speaker 2 of 10
* Robert C. Rickert, Pfizer Inc., USA

Monday, April 24 | 2:30PM - 4:30PM
Workshop 1: B Cell Memory and Plasma Cells
Room: Sea to Sky B/C

Speaker 3 of 10
Kerstin Narr, University of Basel, Switzerland
Interferon-Driven Deletion of Antiviral B Cells at the Onset of Chronic Infection

Monday, April 24 | 2:30PM - 4:30PM
Workshop 1: B Cell Memory and Plasma Cells
Room: Sea to Sky B/C

Speaker 4 of 10
Daniel Lingwood, Havard Medical School, USA
DC-Dependent Control Over the Initiation of Humoral Immunity

Monday, April 24 | 2:30PM - 4:30PM
Workshop 1: B Cell Memory and Plasma Cells
Room: Sea to Sky B/C

Speaker 5 of 10
Mary M. Tomayko, Yale University School of Medicine, USA
B Cell Memory Formation Requires Bone Morphogenetic Protein Receptor Ia

Monday, April 24 | 2:30PM - 4:30PM
Workshop 1: B Cell Memory and Plasma Cells
Room: Sea to Sky B/C

Speaker 6 of 10
Deborah L. Burnett, Garvan Institute of Medical Research, Australia
Somatic Hypermutation Serves Two Independent Functions: Antibody Maturation Away from Binding Self and towards Binding Foreign

Monday, April 24 | 2:30PM - 4:30PM
Workshop 1: B Cell Memory and Plasma Cells
Room: Sea to Sky B/C

Speaker 7 of 10
Joshua F. Koenig, McMaster University, Canada
Long-Lived Memory B Cells Maintain Th2 Humoral Immunity for a Lifetime

Monday, April 24 | 2:30PM - 4:30PM
Workshop 1: B Cell Memory and Plasma Cells
Room: Sea to Sky B/C

Speaker 8 of 10
Sandra Nielsen, Stanford University, USA
Human Immune Responses to Controlled Necator Americanus (Hookworm) Infection

Monday, April 24 | 2:30PM - 4:30PM
Workshop 1: B Cell Memory and Plasma Cells
Room: Sea to Sky B/C

Speaker 9 of 10
Deepta Bhattacharya, Washington University School of Medicine, USA
Metabolic Control of Plasma Cell Lifespan and Antibody Secretion

Monday, April 24 | 2:30PM - 4:30PM
Workshop 1: B Cell Memory and Plasma Cells
Room: Sea to Sky B/C

Speaker 10 of 10
Nicolas Hipp, University of Rennes1, France
T Cell Help Mediated by IL-2 Orchestrates BACH2 Downregulation that Allows Plasma Cell Differentiation

Monday, April 24 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Monday, April 24 | 5:00PM - 7:00PM
Transcriptional Regulation of B Cells and Tfh Cells
Room: Sea to Sky B/C

Speaker 1 of 5
* Betty Diamond, Feinstein Institute for Medical Research, USA

Monday, April 24 | 5:00PM - 7:00PM
Transcriptional Regulation of B Cells and Tfh Cells
Room: Sea to Sky B/C

Speaker 2 of 5
Stephen L. Nutt, Walter and Eliza Hall Institute, Australia
The Regulation of Gene Expression in B Cells

Monday, April 24 | 5:00PM - 7:00PM
Transcriptional Regulation of B Cells and Tfh Cells
Room: Sea to Sky B/C

Speaker 3 of 5
Amy Weinmann, University of Alabama at Birmingham, USA
Molecular Regulators of CD4 T Cell Differentiation

Monday, April 24 | 5:00PM - 7:00PM
Transcriptional Regulation of B Cells and Tfh Cells
Room: Sea to Sky B/C

Speaker 4 of 5
Jason Weinstein, Rutgers New Jersey Medical School, USA
Short Talk: The Transcriptional Regulators STAT4 and T-bet Cooperate in Follicular Helper T Cells to Fine-Tune the Viral Specific Humoral Response

Monday, April 24 | 5:00PM - 7:00PM
Transcriptional Regulation of B Cells and Tfh Cells
Room: Sea to Sky B/C

Speaker 5 of 5
Ari M. Melnick, Weill Cornell Medical College, USA
Epigenetic Switches Controlling the Germinal Center Reaction

Monday, April 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Monday, April 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Tuesday, April 25 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Tuesday, April 25 | 8:00AM - 11:15AM
Tfh Programming and Flexibility
Room: Sea to Sky B/C

Speaker 1 of 9
* Ignacio Sanz, Emory University, School of Medicine, USA

Tuesday, April 25 | 8:00AM - 11:15AM
Tfh Programming and Flexibility
Room: Sea to Sky B/C

Speaker 2 of 9
Hai Qi, Tsinghua University, China
Germinal Center T-B Communications

Tuesday, April 25 | 8:00AM - 11:15AM
Tfh Programming and Flexibility
Room: Sea to Sky B/C

Speaker 3 of 9
Shane Crotty, La Jolla Institute for Immunology, USA
Tfh Differentiation and B Cell Responses in the Context of Vaccines and Infections


Tuesday, April 25 | 8:00AM - 11:15AM
Tfh Programming and Flexibility
Room: Sea to Sky B/C


Coffee Break

Tuesday, April 25 | 8:00AM - 11:15AM
Tfh Programming and Flexibility
Room: Sea to Sky B/C

Speaker 5 of 9
Elissa K. Deenick, Garvan Institute of Medical Research, Australia
Short Talk: Over Activation of PI3K Causes Defects in B-Cell Development and Differentiation

Tuesday, April 25 | 8:00AM - 11:15AM
Tfh Programming and Flexibility
Room: Sea to Sky B/C

Speaker 6 of 9
Silvia Preite, National Institutes of Health, USA
Short Talk: Dissecting the Role of Phosphotidylinositol 3-Kinase (PI3K) d in the Germinal Center Reaction through a Mouse Model of Hyperactivated PIK3CD

Tuesday, April 25 | 8:00AM - 11:15AM
Tfh Programming and Flexibility
Room: Sea to Sky B/C

Speaker 7 of 9
Hideki Ueno, Icahn School of Medicine at Mount Sinai, USA
Circulating Tfh1 Cells in Influenza Vaccination

Tuesday, April 25 | 8:00AM - 11:15AM
Tfh Programming and Flexibility
Room: Sea to Sky B/C

Speaker 8 of 9
Dirk Baumjohann, Ludwig-Maximilians-University Munich, Germany
Short Talk: MicroRNAs are Essential for the Maintenance of Tfh Cell Identity and Germinal Centers

Tuesday, April 25 | 8:00AM - 11:15AM
Tfh Programming and Flexibility
Room: Sea to Sky B/C

Speaker 9 of 9
Luis Graca, iMM-Instituto de Medicina Molecular, Portugal
Short Talk: T Follicular Helper (Tfh) and T Follicular Regulatory (Tfr) Cells Have Different TCR-Specificity

Tuesday, April 25 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, April 25 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Tuesday, April 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Tuesday, April 25 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Tuesday, April 25 | 5:00PM - 7:00PM
Lymphocyte Signaling and Diseases
Room: Sea to Sky B/C

Speaker 1 of 5
* Robert Brink, Garvan Institute of Medical Research, Australia

Tuesday, April 25 | 5:00PM - 7:00PM
Lymphocyte Signaling and Diseases
Room: Sea to Sky B/C

Speaker 2 of 5
David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA
Signaling Defects Causing Immune Dysregulation

Tuesday, April 25 | 5:00PM - 7:00PM
Lymphocyte Signaling and Diseases
Room: Sea to Sky B/C

Speaker 3 of 5
Gail A. Bishop, University of Iowa, USA
TRAF3 Inhibits B Cell Survival and Differentiation via Multiple Mechanisms

Tuesday, April 25 | 5:00PM - 7:00PM
Lymphocyte Signaling and Diseases
Room: Sea to Sky B/C

Speaker 4 of 5
Robert C. Rickert, Pfizer Inc., USA
Metabolic Checkpoints and the B Cell Life Cycle

Tuesday, April 25 | 5:00PM - 7:00PM
Lymphocyte Signaling and Diseases
Room: Sea to Sky B/C

Speaker 5 of 5
Christopher D. C. Allen, University of California, San Francisco, USA
Short Talk: IgE Responses Are Regulated by Constitutive Activity of the IgE B Cell Receptor

Tuesday, April 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Tuesday, April 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Wednesday, April 26 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Wednesday, April 26 | 8:00AM - 11:15AM
Autoimmunity and Immunodeficiency - Mice and Man
Room: Sea to Sky B/C

Speaker 1 of 8
* David M. Tarlinton, Monash University, Australia

Wednesday, April 26 | 8:00AM - 11:15AM
Autoimmunity and Immunodeficiency - Mice and Man
Room: Sea to Sky B/C

Speaker 2 of 8
Robert Brink, Garvan Institute of Medical Research, Australia
Circumvention of Normal Antigenic Controls by Rogue Germinal Center B Cells

Wednesday, April 26 | 8:00AM - 11:15AM
Autoimmunity and Immunodeficiency - Mice and Man
Room: Sea to Sky B/C

Speaker 3 of 8
Qiang Pan-Hammarström, Karolinska Institutet, Sweden
DNA Repair Defects and Primary Immunodeficiency

Wednesday, April 26 | 8:00AM - 11:15AM
Autoimmunity and Immunodeficiency - Mice and Man
Room: Sea to Sky B/C


Coffee Break

Wednesday, April 26 | 8:00AM - 11:15AM
Autoimmunity and Immunodeficiency - Mice and Man
Room: Sea to Sky B/C

Speaker 5 of 8
David M. Tarlinton, Monash University, Australia
Guiding B Cells In and Out of Germinal Centers: Many Are Called but Few Are Chosen

Wednesday, April 26 | 8:00AM - 11:15AM
Autoimmunity and Immunodeficiency - Mice and Man
Room: Sea to Sky B/C

Speaker 6 of 8
Alessandra Pernis, Weill Cornell Medicine, USA
Short Talk: Regulation of CD11c+ Tbet+ B Cells in Systemic Autoimmunity

Wednesday, April 26 | 8:00AM - 11:15AM
Autoimmunity and Immunodeficiency - Mice and Man
Room: Sea to Sky B/C

Speaker 7 of 8
Corey Tan, University of California, San Francisco, USA
Short Talk: Nur77 Expression Marks Autoreactive B Cells in vivo and Enforces Tolerance

Wednesday, April 26 | 8:00AM - 11:15AM
Autoimmunity and Immunodeficiency - Mice and Man
Room: Sea to Sky B/C

Speaker 8 of 8
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Unexpected Roles of Dendritic Cells in Regulating Extrafollicular (EF) Plasmablast Responses

Wednesday, April 26 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, April 26 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Wednesday, April 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Wednesday, April 26 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Wednesday, April 26 | 5:00PM - 7:00PM
GCs, Tfh Cells and Disease
Room: Sea to Sky B/C

Speaker 1 of 5
* Kim Good-Jacobson, Monash University, Australia

Wednesday, April 26 | 5:00PM - 7:00PM
GCs, Tfh Cells and Disease
Room: Sea to Sky B/C

Speaker 2 of 5
Laura Pasqualucci, Columbia University, USA
Genetic-Driven Epigenetic Dysregulation in B Cell Non-Hodgkin Lymphoma

Wednesday, April 26 | 5:00PM - 7:00PM
GCs, Tfh Cells and Disease
Room: Sea to Sky B/C

Speaker 3 of 5
Karin Tarte, INSERM U917 Université de Rennes 1, France
GC B-Cell Malignancies and the Tumor Microenvironment

Wednesday, April 26 | 5:00PM - 7:00PM
GCs, Tfh Cells and Disease
Room: Sea to Sky B/C

Speaker 4 of 5
Stephanie C. Eisenbarth, Yale University, USA
Short Talk: Dock8 Deficiency Reveals the Role of Dendritic Cell Subsets in Tfh Cell Priming

Wednesday, April 26 | 5:00PM - 7:00PM
GCs, Tfh Cells and Disease
Room: Sea to Sky B/C

Speaker 5 of 5
Marcus R. Clark, University of Chicago, USA
Quantifying adaptive cell networks in human inflammation

Wednesday, April 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Wednesday, April 26 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky A


Thursday, April 27 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Thursday, April 27 | 8:00AM - 11:15AM
B Cell Regulation: Intrinsic and Extrinsic Mechanisms
Room: Sea to Sky B/C

Speaker 1 of 8
* Gail A. Bishop, University of Iowa, USA

Thursday, April 27 | 8:00AM - 11:15AM
B Cell Regulation: Intrinsic and Extrinsic Mechanisms
Room: Sea to Sky B/C

Speaker 2 of 8
Peter Sage, Harvard Medical School, USA
T Follicular Regulatory Cells and Regulation of Humoral Immunity

Thursday, April 27 | 8:00AM - 11:15AM
B Cell Regulation: Intrinsic and Extrinsic Mechanisms
Room: Sea to Sky B/C

Speaker 3 of 8
Ignacio Sanz, Emory University, School of Medicine, USA
A New Effector B Cell Pathway with Defective Negative Regulation of TLR7 Signaling in Human SLE

Thursday, April 27 | 8:00AM - 11:15AM
B Cell Regulation: Intrinsic and Extrinsic Mechanisms
Room: Sea to Sky B/C


Coffee Break

Thursday, April 27 | 8:00AM - 11:15AM
B Cell Regulation: Intrinsic and Extrinsic Mechanisms
Room: Sea to Sky B/C

Speaker 5 of 8
Betty Diamond, Feinstein Institute for Medical Research, USA
B Cell-Mediated Autoimmunity and Therapeutics

Thursday, April 27 | 8:00AM - 11:15AM
B Cell Regulation: Intrinsic and Extrinsic Mechanisms
Room: Sea to Sky B/C

Speaker 6 of 8
Kathryn A. Pape, University of Minnesota, USA
Short Talk: A Single Heavy Chain Variable Segment Determines the Size, Quality, and Longevity of the Memory B Cell Response to a Protein Antigen


Thursday, April 27 | 8:00AM - 11:15AM
B Cell Regulation: Intrinsic and Extrinsic Mechanisms
Room: Sea to Sky B/C

Speaker 7 of 8
Patrick C. Wilson, University of Chicago, USA
Identification of Influenza-Induced Precursors for Long-Lived Plasma Cells in Humans

Thursday, April 27 | 8:00AM - 11:15AM
B Cell Regulation: Intrinsic and Extrinsic Mechanisms
Room: Sea to Sky B/C

Speaker 8 of 8
Jenna Guthmiller, University of Chicago, USA
Short Talk: B Cell-Intrinsic and -Extrinsic IL-10 Signaling Promotes Germinal Center B Cell Responses and Protective Anti-Plasmodium Humoral Immunity

Thursday, April 27 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, April 27 | 2:30PM - 4:30PM
Workshop 2: Molecular Regulation of the Germinal Center Resp
onse
Room: Sea to Sky B/C

Speaker 1 of 10
* Christopher D. C. Allen, University of California, San Francisco, USA

Thursday, April 27 | 2:30PM - 4:30PM
Workshop 2: Molecular Regulation of the Germinal Center Resp
onse
Room: Sea to Sky B/C

Speaker 2 of 10
* Elissa K. Deenick, Garvan Institute of Medical Research, Australia

Thursday, April 27 | 2:30PM - 4:30PM
Workshop 2: Molecular Regulation of the Germinal Center Resp
onse
Room: Sea to Sky B/C

Speaker 3 of 10
Roza I. Nurieva, University of Texas MD Anderson Cancer Center, USA
STAT1 Is Required for Tfh Lineage Maintenance through Regulation of IL-21 Expression

Thursday, April 27 | 2:30PM - 4:30PM
Workshop 2: Molecular Regulation of the Germinal Center Resp
onse
Room: Sea to Sky B/C

Speaker 4 of 10
Amanda Mener, Emory University, USA
Complement Serves as a Switch between CD4 Independent and Dependent Antibody Responses


Thursday, April 27 | 2:30PM - 4:30PM
Workshop 2: Molecular Regulation of the Germinal Center Resp
onse
Room: Sea to Sky B/C

Speaker 5 of 10
Mark Andrew Noviski, University of California, San Francisco, USA
Differential Responsiveness of IgM and IgD to Self-Antigens

Thursday, April 27 | 2:30PM - 4:30PM
Workshop 2: Molecular Regulation of the Germinal Center Resp
onse
Room: Sea to Sky B/C

Speaker 6 of 10
Kira V. Rubtsova, Eli Lilly and Company, USA
T-Bet Expression in B Cells Drives Lupus-Like Autoimmunity and the Formation of Spontaneous Germinal Centers

Thursday, April 27 | 2:30PM - 4:30PM
Workshop 2: Molecular Regulation of the Germinal Center Resp
onse
Room: Sea to Sky B/C

Speaker 7 of 10
Ankur Saini, Cincinnati Children's Hospital Medical Center, USA
Convergent Genomic Actions of NFATs and IRF4,8 in Activated B Lymphocytes

Thursday, April 27 | 2:30PM - 4:30PM
Workshop 2: Molecular Regulation of the Germinal Center Resp
onse
Room: Sea to Sky B/C

Speaker 8 of 10
Chris Scharer, Emory University, USA
Ezh2 Is Required for the Division-Specific Epigenetic Programming of Plasma Cell Differentiation

Thursday, April 27 | 2:30PM - 4:30PM
Workshop 2: Molecular Regulation of the Germinal Center Resp
onse
Room: Sea to Sky B/C

Speaker 9 of 10
Mridu Acharya, Benaroya Research Institute, USA
Alpha(v) Integrins Engage Autophagy Proteins to Regulate Toll-Like Receptor Signaling in B Cells

Thursday, April 27 | 2:30PM - 4:30PM
Workshop 2: Molecular Regulation of the Germinal Center Resp
onse
Room: Sea to Sky B/C

Speaker 10 of 10
David R. Glass, Stanford University, USA
Comprehensive Single Cell Phenotyping of Human B Cells Reveals Broad Heterogeneity within Previously Defined Compartments

Thursday, April 27 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Thursday, April 27 | 5:00PM - 7:00PM
Germinal Center Dynamics
Room: Sea to Sky B/C

Speaker 1 of 5
* Shane Crotty, La Jolla Institute for Immunology, USA

Thursday, April 27 | 5:00PM - 7:00PM
Germinal Center Dynamics
Room: Sea to Sky B/C

Speaker 2 of 5
Tri Giang Phan, Garvan Institute of Medical Research, Australia
Optimal Search Strategies for B Cell Encounter with Antigen and T Cell Help in Primary and Secondary Antibody Responses

Thursday, April 27 | 5:00PM - 7:00PM
Germinal Center Dynamics
Room: Sea to Sky B/C

Speaker 3 of 5
Kim Good-Jacobson, Monash University, Australia
Transcriptional and Epigenetic Regulation of B Cell Differentiation

Thursday, April 27 | 5:00PM - 7:00PM
Germinal Center Dynamics
Room: Sea to Sky B/C

Speaker 4 of 5
Jonatan Ersching, Rockefeller University, USA
Short Talk: Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1

Thursday, April 27 | 5:00PM - 7:00PM
Germinal Center Dynamics
Room: Sea to Sky B/C

Speaker 5 of 5
Jason G. Cyster, HHMI/University of California, San Francisco, USA
Guidance Cues for T-Dependent B Cell Activation and Differentiation

Thursday, April 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Thursday, April 27 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, April 27 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Friday, April 28 | 10:25AM - 10:25AM
Departure


*Session Chair.