Web Desc
Modeling Viral Infections and Immunity
Organizer(s): Alan S. Perelson, Rob J. De Boer and Phillip D. Hodgkin
Date: May 01 - 04, 2017
Location: Stanley Hotel, Estes Park, CO, USA
Sponsored by Merck & Co., Inc.
Summary of Meeting:
Viral infection modeling has provided insights into the pathogenesis and treatment of HIV, HCV, HSV-2, CMV and other viruses. It has had impact in revealing the lifespan of infected cells, how rapidly virus is produced and cleared from the circulation, and the means for evaluating the effectiveness of antiviral treatments. HIV remains a global health threat and there is great interest in revealing features of the main HIV reservoir, latently infected cells and mechanisms of reducing the size of this reservoir by pharmacological means. Other important gaps in knowledge revolve around the cell-mediated and humoral immune responses to HIV, important for generating vaccines and broadly neutralizing antibodies as therapeutics, topics that will be discussed. Further, viral infections generally occur in tissues and thus the meeting will discuss imaging techniques and methods of modeling and analyzing spatial infection data, the role of tissue-resident memory cells, and important features of immune regulation, such as immune exhaustion, cytokine signaling between cells, and viral subversion of innate responses and escape from adaptive responses. The meeting will highlight what we believe are significant hurdles to curing viral infections and will bring together experimental virologists, physician scientists and modelers of various types and experience, groups that do not normally meet. It should foster new collaborations between experimentalists and theoreticians, and between theoreticians working on different viral infections or different aspects of viral infections, as well as help young scientists formulate new research directions and make connections with established senior scientists.
Scholarship Deadline: January 10 2017
Discounted Abstract Deadline: January 10 2017
Abstract Deadline: February 1 2017
Discounted Registration Deadline: March 1 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Merck & Co., Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI131602-01
Funding for this conference was made possible (in part) by AI 131602 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, May 01 | 4:00PM - 8:00PM
Arrival and Registration
Room: Hotel Lobby


Monday, May 01 | 6:00PM - 8:00PM
Welcome Mixer
Room: Music Room
No registration fees are used to fund alcohol served at this function.

Tuesday, May 02 | 7:30AM - 8:30AM
Breakfast
Room: MacGregor Ballroom


Tuesday, May 02 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Concert Hall

Speaker 1 of 2
* Alan S. Perelson, Los Alamos National Laboratory, USA

Tuesday, May 02 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Concert Hall

Speaker 2 of 2
Robert F. Siliciano, Johns Hopkins University School of Medicine, USA
Modeling HIV Infection: Insights into Treatment and the Possibility of Cure

Tuesday, May 02 | 9:30AM - 12:00PM
HIV - Barriers to a Cure
Room: Concert Hall

Speaker 1 of 7
* Alan S. Perelson, Los Alamos National Laboratory, USA

Tuesday, May 02 | 9:30AM - 12:00PM
HIV - Barriers to a Cure
Room: Concert Hall

Speaker 2 of 7
Sharon R. Lewin, University of Melbourne, Australia
Optimizing Latency Reversal to Eliminate HIV Persistence on Antiretroviral Therapy

Tuesday, May 02 | 9:30AM - 12:00PM
HIV - Barriers to a Cure
Room: Concert Hall


Coffee Break

Tuesday, May 02 | 9:30AM - 12:00PM
HIV - Barriers to a Cure
Room: Concert Hall

Speaker 4 of 7
Alison L. Hill, Harvard University, USA
Modeling the Dynamics of HIV Latency, Rebound, and Control

Tuesday, May 02 | 9:30AM - 12:00PM
HIV - Barriers to a Cure
Room: Concert Hall

Speaker 5 of 7
Miles P. Davenport, University of New South Wales, Australia
The Dynamics of HIV / SIV Latency

Tuesday, May 02 | 9:30AM - 12:00PM
HIV - Barriers to a Cure
Room: Concert Hall

Speaker 6 of 7
John Michael Murray, University of New South Wales, Australia
Short Talk: Perturbations of the Latent Reservoir to Achieve a Functional Cure

Tuesday, May 02 | 9:30AM - 12:00PM
HIV - Barriers to a Cure
Room: Concert Hall

Speaker 7 of 7
Audrey Fahrny, University Hospital Zurich, Switzerland
Short Talk: A HIV-1 Persistence Humanized Mouse Model for the Characterization of HIV-1 Reservoir Cells

Tuesday, May 02 | 12:00PM - 5:00PM
On Own for Lunch


Tuesday, May 02 | 12:00PM - 1:00PM
Poster Setup
Room: MacGregor Ballroom


Tuesday, May 02 | 1:00PM - 10:00PM
Poster Viewing
Room: MacGregor Ballroom


Tuesday, May 02 | 2:30PM - 4:30PM
Workshop 1: Modeling HIV Infection
Room: Concert Hall

Speaker 1 of 9
* Roland R. Regoes, Integrative Biology, ETH Zurich, Switzerland

Tuesday, May 02 | 2:30PM - 4:30PM
Workshop 1: Modeling HIV Infection
Room: Concert Hall

Speaker 2 of 9
Catherine A.A. Beauchemin, Ryerson University, Canada
Duration of SHIV Production by Infected Cells Is Not Exponentially Distributed: Implications for Estimates of Infection Parameters and Antiviral Efficacy

Tuesday, May 02 | 2:30PM - 4:30PM
Workshop 1: Modeling HIV Infection
Room: Concert Hall

Speaker 3 of 9
Erwing F. Cardozo-Ojeda, Los Alamos National Laboratory, USA
Dynamics of HIV-1 in Chronically Infected Individuals during Therapy with Raltegravir

Tuesday, May 02 | 2:30PM - 4:30PM
Workshop 1: Modeling HIV Infection
Room: Concert Hall

Speaker 4 of 9
Stanca M. Ciupe, Virginia Tech, USA
The Role of Antibody during SIV Infections in Rhesus Macaques

Tuesday, May 02 | 2:30PM - 4:30PM
Workshop 1: Modeling HIV Infection
Room: Concert Hall

Speaker 5 of 9
Jason M. Hataye, National Institutes of Health, USA
Rebound Establishment of HIV Dependent on Burst Size Breakthrough of a Growth Threshold

Tuesday, May 02 | 2:30PM - 4:30PM
Workshop 1: Modeling HIV Infection
Room: Concert Hall

Speaker 6 of 9
Vincent Madelain, INSERM, France
Modeling Viral Kinetics Predicts a Rapid Establishment of the Cytotoxic Immune Response Targeting Distinct
Infected Cell Compartments in SIV Controller Macaques


Tuesday, May 02 | 2:30PM - 4:30PM
Workshop 1: Modeling HIV Infection
Room: Concert Hall

Speaker 7 of 9
Angie Raad, York University, Canada
A Mathematical Model Predicting Restored T Cell Homeostasis as a Major Contributor to the Decay in HIV Persistence

Tuesday, May 02 | 2:30PM - 4:30PM
Workshop 1: Modeling HIV Infection
Room: Concert Hall

Speaker 8 of 9
Daniel Reeves, Fred Hutchinson Cancer Research Center, USA
Long-Term Antiretroviral Therapy Shifts the Mechanism of HIV Persistence toward Proliferating Latently Infected Cells

Tuesday, May 02 | 2:30PM - 4:30PM
Workshop 1: Modeling HIV Infection
Room: Concert Hall

Speaker 9 of 9
Robin N. Thompson, University of Oxford, UK
Accounting for Donor Viral Diversity Gives High Estimates of the Number of HIV Founder Virions among Recipients

Tuesday, May 02 | 4:30PM - 5:00PM
Coffee Available
Room: Concert Hall


Tuesday, May 02 | 5:00PM - 7:00PM
Modeling Cellular Immune Responses
Room: Concert Hall

Speaker 1 of 5
* Phillip D. Hodgkin, Walter and Eliza Hall Institute of Medical Research, Australia

Tuesday, May 02 | 5:00PM - 7:00PM
Modeling Cellular Immune Responses
Room: Concert Hall

Speaker 2 of 5
Andrew J. McMichael, Oxford University, UK
Cell-Mediated Immune Responses to HIV

Tuesday, May 02 | 5:00PM - 7:00PM
Modeling Cellular Immune Responses
Room: Concert Hall

Speaker 3 of 5
Rob J. De Boer, Utrecht University, Netherlands
Broad CD8 Immune Responses to HIV

Tuesday, May 02 | 5:00PM - 7:00PM
Modeling Cellular Immune Responses
Room: Concert Hall

Speaker 4 of 5
Becca Asquith, Imperial College London, UK
KIRs, CD8+ T Cell Dynamics and Control of Chronic Viral Infection

Tuesday, May 02 | 5:00PM - 7:00PM
Modeling Cellular Immune Responses
Room: Concert Hall

Speaker 5 of 5
Lydie Trautmann, US Military HIV Research Program, USA
Short Talk: Immune Cell Dynamics in Lymph Node and Blood during Acute HIV Infection

Tuesday, May 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: MacGregor Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, May 02 | 7:30PM - 10:00PM
Poster Session 1
Room: MacGregor Ballroom


Wednesday, May 03 | 7:30AM - 8:30AM
Breakfast
Room: MacGregor Ballroom


Wednesday, May 03 | 8:30AM - 11:45AM
Spatial Aspects of Infection
Room: Concert Hall

Speaker 1 of 7
* Rob J. De Boer, Utrecht University, Netherlands

Wednesday, May 03 | 8:30AM - 11:45AM
Spatial Aspects of Infection
Room: Concert Hall

Speaker 2 of 7
Scott N. Mueller, University of Melbourne, Australia
Dissecting the Dynamics of Antiviral Immunity and the Lymphoid Tissue Microenvironment

Wednesday, May 03 | 8:30AM - 11:45AM
Spatial Aspects of Infection
Room: Concert Hall

Speaker 3 of 7
Joshua T. Schiffer, Fred Hutchinson Cancer Research Center, USA
Thresholds of Protection for Tissue-Resident T-Cells

Wednesday, May 03 | 8:30AM - 11:45AM
Spatial Aspects of Infection
Room: Concert Hall


Coffee Break

Wednesday, May 03 | 8:30AM - 11:45AM
Spatial Aspects of Infection
Room: Concert Hall

Speaker 5 of 7
Ruy M. Ribeiro, University of Lisbon, Portugal
Spatial Aspects of Hepatitis C Virus Infection

Wednesday, May 03 | 8:30AM - 11:45AM
Spatial Aspects of Infection
Room: Concert Hall

Speaker 6 of 7
Jean-Pierre Levraud, Institut Pasteur, France
Short Talk: From Whole-Body Imaging to Whole-Body Modeling of Viral Infection in Zebrafish

Wednesday, May 03 | 8:30AM - 11:45AM
Spatial Aspects of Infection
Room: Concert Hall

Speaker 7 of 7
Richard Beck, Leiden Academic Centre for Drug Research, Netherlands
Short Talk: Direct T Cell-Mediated Killing of Solid Tumours Is Insufficient to Explain Tumor Regression

Wednesday, May 03 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, May 03 | 11:45AM - 1:00PM
Poster Setup
Room: MacGregor Ballroom


Wednesday, May 03 | 1:00PM - 10:00PM
Poster Viewing
Room: MacGregor Ballroom


Wednesday, May 03 | 4:30PM - 5:00PM
Coffee Available
Room: Concert Hall


Wednesday, May 03 | 5:00PM - 7:00PM
Modeling Viral Infection
Room: Concert Hall

Speaker 1 of 5
* Jane Heffernan, York University, Canada

Wednesday, May 03 | 5:00PM - 7:00PM
Modeling Viral Infection
Room: Concert Hall

Speaker 2 of 5
Thomas Hofer, Deutsches Krebsforschungszentrum, Germany
Dengue Virus Spread and Innate Immune Response at the Single-Cell Level

Wednesday, May 03 | 5:00PM - 7:00PM
Modeling Viral Infection
Room: Concert Hall

Speaker 3 of 5
Narendra M. Dixit, Indian Institute of Science, India
Viral Infection and Subversion of the Interferon Response

Wednesday, May 03 | 5:00PM - 7:00PM
Modeling Viral Infection
Room: Concert Hall

Speaker 4 of 5
Amber M. Smith, University of Tennessee Health Science Center, USA
Modeling the Lethal Synergism of Influenza A Virus and Pneumococcal Coinfection

Wednesday, May 03 | 5:00PM - 7:00PM
Modeling Viral Infection
Room: Concert Hall

Speaker 5 of 5
Frederik Graw, Heidelberg University, Germany
Short Talk: Towards Understanding Malaria Pathogenesis and Efficient Experimental Vaccination

Wednesday, May 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: MacGregor Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, May 03 | 7:30PM - 10:00PM
Poster Session 2
Room: MacGregor Ballroom


Thursday, May 04 | 7:30AM - 8:30AM
Breakfast
Room: MacGregor Ballroom


Thursday, May 04 | 8:30AM - 11:30AM
Using Big Data to Understand Viral Infection
Room: Concert Hall

Speaker 1 of 7
* Lars Kaderali, University Medicine Greifswald, Germany

Thursday, May 04 | 8:30AM - 11:30AM
Using Big Data to Understand Viral Infection
Room: Concert Hall

Speaker 2 of 7
Thierry Mora, École Normale Supérieure, France
Analyzing High-Throughput Sequence Data to Understand Immune Repertoire Diversity and Affinity

Thursday, May 04 | 8:30AM - 11:30AM
Using Big Data to Understand Viral Infection
Room: Concert Hall

Speaker 3 of 7
Steven H. Kleinstein, Yale University School of Medicine, USA
Systems Immunology of Influenza Infection and Vaccination

Thursday, May 04 | 8:30AM - 11:30AM
Using Big Data to Understand Viral Infection
Room: Concert Hall


Coffee Break

Thursday, May 04 | 8:30AM - 11:30AM
Using Big Data to Understand Viral Infection
Room: Concert Hall

Speaker 5 of 7
Katia Koelle, Duke University, USA
Capturing the Roles of Cellular Coinfection and Viral Complementation in the Within-Host Dynamics of Influenza

Thursday, May 04 | 8:30AM - 11:30AM
Using Big Data to Understand Viral Infection
Room: Concert Hall

Speaker 6 of 7
Thomas B. Kepler, Boston University, USA
Affinity Maturation in Humans: Immunization, Analysis and Modeling

Thursday, May 04 | 8:30AM - 11:30AM
Using Big Data to Understand Viral Infection
Room: Concert Hall

Speaker 7 of 7
Florian Rubelt, Stanford University, USA
Short Talk: Distinctive Differences in T Cell Receptor Repertoire and Cell Frequencies Are Evident in Individual Immune Responses

Thursday, May 04 | 11:30AM - 5:00PM
On Own for Lunch


Thursday, May 04 | 2:30PM - 4:30PM
Workshop 2: Modeling Other Virus Infectious and Immune Respo
nses
Room: Concert Hall

Speaker 1 of 9
* Vitaly V. Ganusov, University of Tennessee, USA

Thursday, May 04 | 2:30PM - 4:30PM
Workshop 2: Modeling Other Virus Infectious and Immune Respo
nses
Room: Concert Hall

Speaker 2 of 9
Ruian Ke, North Carolina State University, USA
Modeling the Mechanistic Action and Predicting the Impact of an Immunotherapeutic DART® Molecule in HIV 'Shock and Kill' Strategies

Thursday, May 04 | 2:30PM - 4:30PM
Workshop 2: Modeling Other Virus Infectious and Immune Respo
nses
Room: Concert Hall

Speaker 3 of 9
Wen-Han Yu, Gates Medical Research Institute, USA
Multivariate Modeling of Immunological Profilings from HIV Vaccine Trials Cross-Predicts Vaccine Protection and Infers the Underlying Mechanisms

Thursday, May 04 | 2:30PM - 4:30PM
Workshop 2: Modeling Other Virus Infectious and Immune Respo
nses
Room: Concert Hall

Speaker 4 of 9
Nathanael Hoze, ETH Zurich, Switzerland
Quantitative Delineation of Antibody Composition from Polyclonal Plasmas

Thursday, May 04 | 2:30PM - 4:30PM
Workshop 2: Modeling Other Virus Infectious and Immune Respo
nses
Room: Concert Hall

Speaker 5 of 9
Shingo Iwami, Kyushu University, Japan
Optimizing Drug Combinations against Hepatitis C Virus Infection in Pre-Clinical Setting

Thursday, May 04 | 2:30PM - 4:30PM
Workshop 2: Modeling Other Virus Infectious and Immune Respo
nses
Room: Concert Hall

Speaker 6 of 9
Christopher Dächert, German Cancer Research Center - DKFZ, Germany
Understanding the Fight by Looking at the Soldiers - A Quantitative Systems Biology Approach to Analyze the
Dynamic Host-Virus-Interactions by the Example of Hepatitis C Virus


Thursday, May 04 | 2:30PM - 4:30PM
Workshop 2: Modeling Other Virus Infectious and Immune Respo
nses
Room: Concert Hall

Speaker 7 of 9
Laura Liao, Ryerson University, Canada
Counting Defective Interfering Particles: Easy as 1, 2, 3 ...?

Thursday, May 04 | 2:30PM - 4:30PM
Workshop 2: Modeling Other Virus Infectious and Immune Respo
nses
Room: Concert Hall

Speaker 8 of 9
Katharine Best, Los Alamos National Laboratory, USA
Modeling Zika Plasma Viral Dynamics in Non-Human Primates: Insights into Viral Pathogenesis and Antiviral Strategies

Thursday, May 04 | 2:30PM - 4:30PM
Workshop 2: Modeling Other Virus Infectious and Immune Respo
nses
Room: Concert Hall

Speaker 9 of 9
Sanket Rane, Columbia University, USA
Age Is Not Just A Number – Time Since Thymic Export Influences Homeostatic Fitness and Drives the Accumulation of Veteran Naïve T Cells in Mice

Thursday, May 04 | 4:30PM - 5:00PM
Coffee Available
Room: Concert Hall


Thursday, May 04 | 5:00PM - 6:45PM
Modeling Immune Regulation
Room: Concert Hall

Speaker 1 of 4
* Sebastian L. Bonhoeffer, ETH-Zentrum, Switzerland

Thursday, May 04 | 5:00PM - 6:45PM
Modeling Immune Regulation
Room: Concert Hall

Speaker 2 of 4
Phillip D. Hodgkin, Walter and Eliza Hall Institute of Medical Research, Australia
Formation of Effector and Memory Cells

Thursday, May 04 | 5:00PM - 6:45PM
Modeling Immune Regulation
Room: Concert Hall

Speaker 3 of 4
Rustom Antia, Emory University, USA
How Does Prior Immunity Affect the Dynamics of Immune Responses to New Strains of Influenza?

Thursday, May 04 | 5:00PM - 6:45PM
Modeling Immune Regulation
Room: Concert Hall

Speaker 4 of 4
Alan S. Perelson, Los Alamos National Laboratory, USA
Modeling Antibodies and HIV Cure

Thursday, May 04 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Concert Hall


Thursday, May 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: MacGregor Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, May 04 | 8:00PM - 11:00PM
Entertainment
Room: MacGregor Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, May 04 | 8:00PM - 11:00PM
Cash Bar
Room: MacGregor Ballroom


Friday, May 05 | 10:25AM - 10:25AM
Departure


*Session Chair.