Web Desc
Integrating Metabolism and Immunity
joint with Cell Death and Inflammation
Organizer(s): Hongbo Chi, Erika L. Pearce, Richard A. Flavell and Luke A.J. O'Neill
Date: May 29 - June 02, 2017
Location: Royal Dublin Society, Dublin 4, Ireland
Organized in Collaboration with Science Foundation Ireland
Sponsored by AbbVie Inc., MSD, Novo Nordisk A/S and Pfizer Inc.
Summary of Meeting:
The coordination of metabolic programs with immune cell fate is a fundamental event in immunity. Immune cells are known for their ability to rapidly transition from resting to activated states in response to external stimuli. Typically, their activation is accompanied by increased expression of large panels of immune effector molecules, and in the case of lymphocytes, is also accompanied by extensive and rapid cellular proliferation. Recent studies have revealed the fundamental importance of metabolic reprogramming, including dynamic regulation of aerobic glycolysis (the Warburg effect), lipid synthesis and degradation, and mitochondrial activity, in immune cell activation and differentiation and the outcome of immune responses. This process depends upon the interplay between the metabolic machinery and immune signaling and transcriptional pathways, and is further shaped by the availability of metabolic substrates and nutrients within the cells and in the microenvironment, including those produced by microbiota. The critical link between metabolism and immunity is indicated by findings that aberrant immune cell metabolism not only affects inflammatory responses and adaptive immunity, but also contributes to metabolic disorders. The goal of this Keystone Symposia meeting is to bring together leading investigators working on metabolism (organismal, cellular, and microbial metabolism) and immunobiology. Additional opportunities for interdisciplinary interactions will be provided by the discussion on central metabolism and the contribution of key metabolic substrates by the microbiota. The latest discoveries will be discussed in the context of basic biology and how it can be exploited to design new therapeutics targeting inflammatory and metabolic disorders.
Scholarship Deadline: January 31 2017
Discounted Abstract Deadline: January 31 2017
Abstract Deadline: March 1 2017
Discounted Registration Deadline: March 29 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AbbVie Inc.MSDNovo Nordisk A/SPfizer Inc.Science Foundation Ireland
We gratefully acknowledge additional support for this conference from:
Don Whitley Scientific LimitedSeahorse Bioscience, a part of Agilent TechnologiesThird Rock Ventures
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
American Association for the Advancement of Science (AAAS)
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI131607-01
Funding for this conference was made possible (in part) by AI131607-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, May 29 | 4:00PM - 8:00PM
Arrival and Registration
Room: Hall 4


Monday, May 29 | 6:00PM - 8:00PM
Welcome Mixer
Room: Hall 4
No registration fees are used to fund alcohol served at this function.

Tuesday, May 30 | 8:00AM - 9:00AM
Breakfast
Room: Individual Hotel


Tuesday, May 30 | 9:00AM - 10:30AM
Welcome and Keynote Session (Joint)
Room: Hall 3

Speaker 1 of 5
* Hongbo Chi, St. Jude Children's Research Hospital, USA

Tuesday, May 30 | 9:00AM - 10:30AM
Welcome and Keynote Session (Joint)
Room: Hall 3

Speaker 2 of 5
* Seamus J. Martin, Trinity College Dublin, Ireland

Tuesday, May 30 | 9:00AM - 10:30AM
Welcome and Keynote Session (Joint)
Room: Hall 3

Speaker 3 of 5
Diane Mathis, Harvard Medical School, USA
T Cell Control of Organismal Metabolism

Tuesday, May 30 | 9:00AM - 10:30AM
Welcome and Keynote Session (Joint)
Room: Hall 3

Speaker 4 of 5
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Tissue Homeostasis and Inflammation

Tuesday, May 30 | 9:00AM - 10:30AM
Welcome and Keynote Session (Joint)
Room: Hall 3


Coffee Break

Tuesday, May 30 | 10:50AM - 1:00PM
Glucose Metabolism to Fuel Immune Cell Functions
Room: Hall 3

Speaker 1 of 5
* Jeffrey C. Rathmell, Vanderbilt University, USA
Glut1 and Metabolic Reprogramming of CD4 T Cell Subsets


Tuesday, May 30 | 10:50AM - 1:00PM
Glucose Metabolism to Fuel Immune Cell Functions
Room: Hall 3

Speaker 2 of 5
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
The Warburg Effect in LPS-Activated Macrophages

Tuesday, May 30 | 10:50AM - 1:00PM
Glucose Metabolism to Fuel Immune Cell Functions
Room: Hall 3

Speaker 3 of 5
Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Glucose Metabolism in Alternative Macrophage Activation

Tuesday, May 30 | 10:50AM - 1:00PM
Glucose Metabolism to Fuel Immune Cell Functions
Room: Hall 3

Speaker 4 of 5
Thomas Weichhart, Medical University of Vienna, Austria
Short Talk: Metabolic Aspects of Granuloma Formation by Macrophages Regulated by mTORC1

Tuesday, May 30 | 10:50AM - 1:00PM
Glucose Metabolism to Fuel Immune Cell Functions
Room: Hall 3

Speaker 5 of 5
Maxim Artyomov, Washington University in St. Louis, USA
Short Talk: Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

Tuesday, May 30 | 10:50AM - 12:45PM
Inflammatory Responses to Cell Death I
This session is from Cell Death
Room: Concert Hall

Speaker 1 of 6
* Seamus J. Martin, Trinity College Dublin, Ireland


Tuesday, May 30 | 10:50AM - 12:45PM
Inflammatory Responses to Cell Death I
This session is from Cell Death
Room: Concert Hall

Speaker 2 of 6
Kenneth L. Rock, University of Massachusetts Medical School, USA
DAMPs and Inflammation


Tuesday, May 30 | 10:50AM - 12:45PM
Inflammatory Responses to Cell Death I
This session is from Cell Death
Room: Concert Hall

Speaker 3 of 6
David Wallach, Weizmann Institute of Science, Israel
Non-Deadly Pro-Inflammatory Functions of Mechanisms that Signal for Programmed Necrosis


Tuesday, May 30 | 10:50AM - 12:45PM
Inflammatory Responses to Cell Death I
This session is from Cell Death
Room: Concert Hall

Speaker 4 of 6
John Silke, Walter and Eliza Hall Institute of Medical Research, Australia
Beware the MLKL, the Jaws that Bite: Uffish Thoughts on the Role of Necroptosis and Inflammation


Tuesday, May 30 | 10:50AM - 12:45PM
Inflammatory Responses to Cell Death I
This session is from Cell Death
Room: Concert Hall

Speaker 5 of 6
Stephen Tait, Cancer Research UK Beatson Institute, UK
Short Talk: Mitochondrial Permeabilization Engages NFkB and Anti-Tumor Immunity under Caspase-Deficient Conditions


Tuesday, May 30 | 10:50AM - 12:45PM
Inflammatory Responses to Cell Death I
This session is from Cell Death
Room: Concert Hall

Speaker 6 of 6
Kate E. Lawlor, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Cell Death-Induced Inflammasome Activation: Mechanisms and Disease Relevance


Tuesday, May 30 | 1:00PM - 4:00PM
On Own for Lunch


Tuesday, May 30 | 1:00PM - 1:30PM
Poster Setup
Room: Hall 4


Tuesday, May 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Hall 4


Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
Room: Hall 3

Speaker 1 of 8
* David K. Finlay, Trinity Biomedical Sciences Institute, Ireland

Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
Room: Hall 3

Speaker 2 of 8
* Madhusudhanan Sukumar, NCI, National Institutes of Health, USA

Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
Room: Hall 3

Speaker 3 of 8
Carlos Carmona-Fontaine, New York University, USA
Metabolic Origins of Spatial Organization in the Tumor Microenvironment

Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
Room: Hall 3

Speaker 4 of 8
Linda V. Sinclair, University of Dundee, UK
Temporally Regulated Amino Acid Uptake through SLC7A5 Is Required for T Follicular Helper Cell Differentiation

Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
Room: Hall 3

Speaker 5 of 8
Roger Geiger, Institute for Research in Biomedicine, Switzerland
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-Tumor Activity

Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
Room: Hall 3

Speaker 6 of 8
Dirk Brenner, Luxembourg Institute of Health, Luxembourg
Glutathione Primes T Cell Metabolism for Inflammation

Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
Room: Hall 3

Speaker 7 of 8
G-One Ahn, Pohang University of Science and Technology, South Korea
Reduced Glycolytic Metabolism in Adipose-Tissue Macrophages Facilitates Lipolysis in Mice

Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
Room: Hall 3

Speaker 8 of 8
Lena Pernas, University of Padua, Italy
Mitochondria Limit Toxoplasma Growth by Competing for Fatty Acids

Tuesday, May 30 | 3:30PM - 4:00PM
Coffee Available
Room: Hall 4


Tuesday, May 30 | 4:00PM - 6:15PM
Transcriptional and Epigenetic Control in Immune Metabolism
Room: Hall 3

Speaker 1 of 6
* Susan M. Kaech, The Salk Institute, USA

Tuesday, May 30 | 4:00PM - 6:15PM
Transcriptional and Epigenetic Control in Immune Metabolism
Room: Hall 3

Speaker 2 of 6
Douglas R. Green, St. Jude Children's Research Hospital, USA
c-Myc and Metabolic Regulation of T Cell Activation and Differentiation

Tuesday, May 30 | 4:00PM - 6:15PM
Transcriptional and Epigenetic Control in Immune Metabolism
Room: Hall 3

Speaker 3 of 6
John J. O'Shea, NIAMS, National Institutes of Health, USA
Regulatory Nodes in T Cells

Tuesday, May 30 | 4:00PM - 6:15PM
Transcriptional and Epigenetic Control in Immune Metabolism
Room: Hall 3

Speaker 4 of 6
Hai-Hui (Howard) Xue, University of Iowa, USA
Short Talk: Runx3 Guards Cytotoxic CD8+ Effectors Against Tfh Deviation in Acute Viral Infection

Tuesday, May 30 | 4:00PM - 6:15PM
Transcriptional and Epigenetic Control in Immune Metabolism
Room: Hall 3

Speaker 5 of 6
Mihai G. Netea, Radboud University, Netherlands
Metabolic and Epigenetic Reprogramming in Myeloid Cells

Tuesday, May 30 | 4:00PM - 6:15PM
Transcriptional and Epigenetic Control in Immune Metabolism
Room: Hall 3

Speaker 6 of 6
Kenneth Smith, University of Cambridge, UK
Short Talk: Distinct Pathways Governing Susceptibility and Patient Outcome in Autoimmune and Inflammatory Disease

Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
This session is from Cell Death
Room: Concert Hall

Speaker 1 of 7
* John Silke, Walter and Eliza Hall Institute of Medical Research, Australia


Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
This session is from Cell Death
Room: Concert Hall

Speaker 2 of 7
Peter Vandenabeele, VIB, Ghent University, Belgium
Role of Ferroptosis in Cancer Treatment and Immunogenic Cell Death (ICD)


Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
This session is from Cell Death
Room: Concert Hall

Speaker 3 of 7
Seamus J. Martin, Trinity College Dublin, Ireland
Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-1 Family Cytokines Released via Necrosis


Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
This session is from Cell Death
Room: Concert Hall

Speaker 4 of 7
Siddharth Balachandran, Fox Chase Cancer Center, USA
Short Talk: Influenza Virus-Activated DAI-RIPK3-Driven Cell Death


Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
This session is from Cell Death
Room: Concert Hall

Speaker 5 of 7
Andrew Oberst, University of Washington, USA
Short Talk: Death-Independent Roles of RIPK1 and RIPK3 in the Restriction of Neuroinvasive Flavivirus Infection


Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
This session is from Cell Death
Room: Concert Hall

Speaker 6 of 7
Murray CH Clarke, Cambridge University, UK
Short Talk: The Coagulation and Immune Systems Are Fundamentally Linked by the Activation of interleukin-1a by Thrombin


Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
This session is from Cell Death
Room: Concert Hall

Speaker 7 of 7
Ranja Salvamoser, Australia
Short Talk: Impact of Deleting All Murine CARD Containing Caspases on Cell Death and Other Cell Signaling Pathways


Tuesday, May 30 | 6:15PM - 7:15PM
Social Hour with Lite Bites
Room: Hall 4
No registration fees are used to fund alcohol served at this function.

Tuesday, May 30 | 6:30PM - 9:00PM
Poster Session 1
Room: Hall 4


Wednesday, May 31 | 8:00AM - 9:00AM
Breakfast
Room: Individual Hotel


Wednesday, May 31 | 8:30AM - 9:00AM
Poster Setup
Room: Hall 4


Wednesday, May 31 | 9:00AM - 5:00PM
Poster Viewing
Room: Hall 4


Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
Room: Hall 3

Speaker 1 of 8
* Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany

Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
Room: Hall 3

Speaker 2 of 8
Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Mitochondrial Priming By CD28

Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
Room: Hall 3

Speaker 3 of 8
Dan R. Littman, HHMI/New York University School of Medicine, USA
Regulation of RORgt Function in Lymphocytes

Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
Room: Hall 3

Speaker 4 of 8
Laurence A. Turka, Rheos Medicines, USA
Short Talk: Maintenance of CD4+ T Cell Metabolic Fitness through Regulation of Foxo1

Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
Room: Hall 3


Coffee Break

Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
Room: Hall 3

Speaker 6 of 8
Tim D. Sparwasser, Institute of Infection and Immunology, Germany
Fatty Acid Metabolism in the Development and Function of T Cell Subsets

Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
Room: Hall 3

Speaker 7 of 8
Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Metabolic Pathways that Regulate Development of Pathogenic Th17 Cells and Autoimmunity

Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
Room: Hall 3

Speaker 8 of 8
Daniel W. McVicar, National Institutes of Health, USA
Short Talk: Itaconic Acid Mediates Crosstalk between Macrophage Metabolism and Tumor Progression

Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
This session is from Cell Death
Room: Concert Hall

Speaker 1 of 10
* Kim Newton, Genentech, Inc., USA


Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
This session is from Cell Death
Room: Concert Hall

Speaker 2 of 10
Mads Gyrd-Hansen, University of Oxford, UK
EMBO Young Investigator Lecture: Regulation of Ubiquitination in Inflammatory Signaling


Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
This session is from Cell Death
Room: Concert Hall

Speaker 3 of 10
Henning Walczak, University College London, Cancer Institute, UK
Cell Death and Ubiquitin in Cancer, Inflammation and Immunity


Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
This session is from Cell Death
Room: Concert Hall

Speaker 4 of 10
Rune Busk Damgaard, Medical Research Council Laboratory of Molecular Biology, UK
Short Talk: The Deubiquitinase OTULIN Restricts M1-Linked Ubiquitin Signaling to Prevent Inflammation and Autoimmunity


Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
This session is from Cell Death
Room: Concert Hall

Speaker 5 of 10
Patricia Brazee, Northwestern University, USA
Short Talk: LUBAC Mediated Epithelial Signaling During Influenza Infection


Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
This session is from Cell Death
Room: Concert Hall


Coffee Break


Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
This session is from Cell Death
Room: Concert Hall

Speaker 7 of 10
Marion MacFarlane, MRC Toxicology Unit, UK
FADD: Caspase-8 Signalling Complexes and Co-ordinated Control of Life/Death Decisions


Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
This session is from Cell Death
Room: Concert Hall

Speaker 8 of 10
Pascal Meier, Institute of Cancer Research, UK
Ubiquitin Signaling in Cell Death and Inflammation


Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
This session is from Cell Death
Room: Concert Hall

Speaker 9 of 10
Nader Yatim, Institut Pasteur, France
Short Talk: RIPK3 in Dendritic Cells Promotes Cross-Priming Upon Stimulation with dsRNA


Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
This session is from Cell Death
Room: Concert Hall

Speaker 10 of 10
Todd Douglas, McGill University, Canada
Short Talk: Caspase-Mediated Cleavage of HOIP Terminates LUBAC Function and Promotes Cell Death 


Wednesday, May 31 | 12:15PM - 1:00PM
Lunch
Room: Hall 4


Wednesday, May 31 | 1:00PM - 3:30PM
Poster Session 2
Room: Hall 4


Wednesday, May 31 | 3:30PM - 4:00PM
Coffee Available
Room: Hall 4


Wednesday, May 31 | 4:00PM - 6:15PM
Mitochondria as Platforms for Key Intracellular Signaling
Room: Hall 3

Speaker 1 of 6
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Wednesday, May 31 | 4:00PM - 6:15PM
Mitochondria as Platforms for Key Intracellular Signaling
Room: Hall 3

Speaker 2 of 6
Navdeep S. Chandel, Northwestern University, USA
Mitochondria as Signaling Organelles

Wednesday, May 31 | 4:00PM - 6:15PM
Mitochondria as Platforms for Key Intracellular Signaling
Room: Hall 3

Speaker 3 of 6
Gerald S. Shadel, The Salk Institute for Biological Studies, USA
A Mitochondrial DNA Stress-Induced ISG Response

Wednesday, May 31 | 4:00PM - 6:15PM
Mitochondria as Platforms for Key Intracellular Signaling
Room: Hall 3

Speaker 4 of 6
David Artis, Weill Cornell Medical College, USA
Immune Regulation at Barrier Surfaces

Wednesday, May 31 | 4:00PM - 6:15PM
Mitochondria as Platforms for Key Intracellular Signaling
Room: Hall 3

Speaker 5 of 6
Mercedes Rincon, University of Vermont, USA
Short Talk: MCJ (DnaJC15) Negatively Regulates CD8+ T Cell Mitochondrial Respiration and Immune Effector Functions

Wednesday, May 31 | 4:00PM - 6:15PM
Mitochondria as Platforms for Key Intracellular Signaling
Room: Hall 3

Speaker 6 of 6
Ping-Chih Ho, University of Lausanne, Switzerland
Short Talk: Integration of alpha-Ketoglutarate/Succinate Balance Controls Macrophage Polarization through Immunometabolic and Epigenetic Reprogramming

Wednesday, May 31 | 4:00PM - 6:00PM
Inflammatory Signaling II
This session is from Cell Death
Room: Concert Hall

Speaker 1 of 6
* Eric H. Baehrecke, University of Massachusetts Medical School, USA


Wednesday, May 31 | 4:00PM - 6:00PM
Inflammatory Signaling II
This session is from Cell Death
Room: Concert Hall

Speaker 2 of 6
Ana Martin-Villalba, DKFZ German Cancer Research Center, Germany
CD95 Inflammatory Activities: A Tale of Myeloid Cells and Vessels


Wednesday, May 31 | 4:00PM - 6:00PM
Inflammatory Signaling II
This session is from Cell Death
Room: Concert Hall

Speaker 3 of 6
Domagoj Vucic, Genentech, Inc., USA
Regulation of Inflammatory Cell Death Signaling by RIP Kinases


Wednesday, May 31 | 4:00PM - 6:00PM
Inflammatory Signaling II
This session is from Cell Death
Room: Concert Hall

Speaker 4 of 6
Elizabeth K. Brint, University College Cork, Ireland
Short Talk: Engagement of Fas Differentially Regulates the Production of LPS-Induced Pro-Inflammatory Cytokines and Type I Interferons


Wednesday, May 31 | 4:00PM - 6:00PM
Inflammatory Signaling II
This session is from Cell Death
Room: Concert Hall

Speaker 5 of 6
Igor E. Brodsky, University of Pennsylvania, USA
Short Talk: RIPK1 Kinase-Dependent Apoptosis Promotes Antibacterial Immunity in Response to Pathogen Inhibition of Inflammatory Signaling


Wednesday, May 31 | 4:00PM - 6:00PM
Inflammatory Signaling II
This session is from Cell Death
Room: Concert Hall

Speaker 6 of 6
Cristina Giogha, Hudson Institute of Medical Research, Australia
Short Talk: A Bacterial Cysteine Protease Effector Targets RHIM Proteins to Block Host Immune Signaling


Wednesday, May 31 | 6:15PM - 6:15PM
On Own for Dinner
No registration fees are used to fund alcohol served at this function.

Thursday, June 01 | 8:00AM - 9:00AM
Breakfast
Room: Individual Hotel


Thursday, June 01 | 8:30AM - 9:00AM
Poster Setup
Room: Hall 4


Thursday, June 01 | 9:00AM - 5:00PM
Poster Viewing
Room: Hall 4


Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
Room: Hall 3

Speaker 1 of 9
* Laurence A. Turka, Rheos Medicines, USA

Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
Room: Hall 3

Speaker 2 of 9
* Mercedes Rincon, University of Vermont, USA

Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
Room: Hall 3

Speaker 3 of 9
Giuseppe Matarese, Università degli Studi di Napoli Federico II, Italy
Metabolic Control of Immune Tolerance and Autoimmune Diseases

Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
Room: Hall 3

Speaker 4 of 9
Jonathan D. Powell, Johns Hopkins University School of Medicine, USA
mTOR Signaling in T Cell Fate, Activation and Metabolism


Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
Room: Hall 3

Speaker 5 of 9
Bin Li, Shanghai Institute of Immunology, China
Short Talk: Regulation of Treg Cell Metabolism and Function by Pkm2 and Foxp3

Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
Room: Hall 3


Coffee Break

Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
Room: Hall 3

Speaker 7 of 9
Hongbo Chi, St. Jude Children's Research Hospital, USA
mTORC1 Signaling and Systems Proteomics in T Cell Metabolic Reprogramming

Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
Room: Hall 3

Speaker 8 of 9
Russell G. Jones, Van Andel Research Institute, USA
Rethinking Metabolic Reprogramming in T Cells

Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
Room: Hall 3

Speaker 9 of 9
Jeroen Roose, University of California, San Francisco, USA
Short Talk: Tonic Signals to Regulate Transcriptional, Translational, and Metabolic Programs in CD4 T Cells

Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
This session is from Cell Death
Room: Concert Hall

Speaker 1 of 9
* Thomas Brunner, University of Konstanz, Germany


Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
This session is from Cell Death
Room: Concert Hall

Speaker 2 of 9
Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Phagocyte Responses to Dying Cells


Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
This session is from Cell Death
Room: Concert Hall

Speaker 3 of 9
Eric H. Baehrecke, University of Massachusetts Medical School, USA
Inflammatory Signaling, Autophagy and Dying Cell Clearance


Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
This session is from Cell Death
Room: Concert Hall

Speaker 4 of 9
Thomas H. Oguin, National Institute of Environmental Health Sciences, USA
Short Talk: LC3-Associated Phagocytosis Is Required to Defend Against Environmental Bacterial Infection


Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
This session is from Cell Death
Room: Concert Hall


Coffee Break


Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
This session is from Cell Death
Room: Concert Hall

Speaker 6 of 9
Ed C. Lavelle, Trinity College Dublin, Ireland
Role of IL-1 Family Cytokines in Adjuvanticity


Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
This session is from Cell Death
Room: Concert Hall

Speaker 7 of 9
Shigekazu Nagata, IFReC, Osaka University, Japan
Exposure of Phosphatidylserine to the Cell Surface


Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
This session is from Cell Death
Room: Concert Hall

Speaker 8 of 9
Akira Shibuya, University of Tsukuba, Japan
Short Talk: Apoptotic Epithelial Cells Control Regulatory T Cell Expansion  


Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
This session is from Cell Death
Room: Concert Hall

Speaker 9 of 9
Conor J. Kearney, Peter MacCallum Cancer Centre, Australia
Short Talk: IAP Antagonists Promote Cytotoxic Lymphocyte Anti-Tumor Immunity


Thursday, June 01 | 12:15PM - 1:00PM
Lunch
Room: Hall 4


Thursday, June 01 | 1:00PM - 3:30PM
Poster Session 3
Room: Hall 4


Thursday, June 01 | 3:30PM - 4:00PM
Coffee Available
Room: Hall 4


Thursday, June 01 | 4:00PM - 6:15PM
Immune-Tissue Interaction in Inflammation and Metabolic Dise
ase

Room: Hall 3

Speaker 1 of 6
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA

Thursday, June 01 | 4:00PM - 6:15PM
Immune-Tissue Interaction in Inflammation and Metabolic Dise
ase

Room: Hall 3

Speaker 2 of 6
Axel Kallies, University of Melbourne, Australia
Molecular Regulation of Adipose Tissue-Resident Regulatory T Cell Development

Thursday, June 01 | 4:00PM - 6:15PM
Immune-Tissue Interaction in Inflammation and Metabolic Dise
ase

Room: Hall 3

Speaker 3 of 6
Lydia Lynch, Harvard Medical School, USA
The Interdependence of Systemic and Cellular Metabolism in Innate Immunity

Thursday, June 01 | 4:00PM - 6:15PM
Immune-Tissue Interaction in Inflammation and Metabolic Dise
ase

Room: Hall 3

Speaker 4 of 6
David K. Finlay, Trinity Biomedical Sciences Institute, Ireland
Short Talk: Fueling Natural Killer Cell Anti-Tumor Responses

Thursday, June 01 | 4:00PM - 6:15PM
Immune-Tissue Interaction in Inflammation and Metabolic Dise
ase

Room: Hall 3

Speaker 5 of 6
Richard M. Locksley, HHMI/University of California, San Francisco, USA
Innate Helper Type 2 Cells (ILC2s) and Intestinal Homeostasis

Thursday, June 01 | 4:00PM - 6:15PM
Immune-Tissue Interaction in Inflammation and Metabolic Dise
ase

Room: Hall 3

Speaker 6 of 6
Giuseppe Danilo Norata, University of Milan, Italy
Short Talk: Dendritic Cells’ Derived Apolipoprotein E Orchestrates Adaptive Immune Response by Controlling Cellular Lipid Metabolism

Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 1 of 7
* Cristina Muñoz-Pinedo, Institut d'Investigacio Biomedica de Bellvitge, Spain


Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 2 of 7
Junying Yuan, Harvard Medical School, USA
The Role and Mechanism of RIPK1 in Cell Death and Neurodegeneration


Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 3 of 7
Kevin M. Ryan, Beatson Institute for Cancer Research, UK
The p53 Pathway and Inflammation


Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 4 of 7
Erwin F. Wagner, Spanish National Cancer Research Centre, Spain
Stress Signaling in Inflammation and Cancer


Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 5 of 7
Lisa Bouchier-Hayes, Baylor College of Medicine, USA
Short Talk: Caspase-1 and Caspase-5 Are Differentially Activated by Extracellular Heme


Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 6 of 7
Joanna Majkut, Queen's University Belfast, UK
Short Talk: Development and Pre-Clinical Assessment of a First-in-Class Small Molecule Inhibitor of FLIP


Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 7 of 7
Adam Lacy-Hulbert, Benaroya Research Institute, USA
Short Talk: A Forward Genetic Screen to Identify Mechanisms of Resistance to Caspase-Mediated Cell Death Induced by Pore-Forming Toxins


Thursday, June 01 | 6:15PM - 6:15PM
On Own for Dinner
No registration fees are used to fund alcohol served at this function.

Friday, June 02 | 8:00AM - 9:00AM
Breakfast
Room: Individual Hotel


Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
Room: Hall 3

Speaker 1 of 8
* Joel D. Schilling, Washington University School of Medicine, USA

Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
Room: Hall 3

Speaker 2 of 8
Mark A. Febbraio, Monash Institute of Pharmaceutical Sciences, Australia
How Do Macrophages Sense Nutrient Overload to Induce an Inflammatory Response?

Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
Room: Hall 3

Speaker 3 of 8
Susan M. Kaech, The Salk Institute, USA
Anti-Tumor T Cells – You Are What You Eat


Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
Room: Hall 3

Speaker 4 of 8
Laurence Morel, University of Florida, USA
Short Talk: Unique Requirement of High Levels of Glucose Metabolism by Autoreactive Follicular Helper T Cells

Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
Room: Hall 3


Coffee Break

Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
Room: Hall 3

Speaker 6 of 8
Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Gut Microbe, Growth Factor Signaling and Metabolic Regulation of Wasting Disease

Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
Room: Hall 3

Speaker 7 of 8
Mala Maini, University College London, UK
Metabolic Regulation of T Cell Immunity in Viral Hepatitis

Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
Room: Hall 3

Speaker 8 of 8
Andreas Bergthaler, Austrian Academy of Sciences, Austria
Short Talk: Systemic Crosstalk of Metabolism and Inflammation in Viral Infection

Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 1 of 10
* Domagoj Vucic, Genentech, Inc., USA


Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 2 of 10
Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany
NETosis and Inflammation


Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 3 of 10
Thomas Brunner, University of Konstanz, Germany
Extra-Adrenal Synthesis of Immunoregulatory Glucocorticoids and its Implication in Local Tissue Homeostasis, Inflammation and Cancer


Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 4 of 10
Ling-Ling An, MedImmune, Inc., USA
Short Talk: ICs-Induced NETosis Requires PAD4 but Not Histone Citrullination


Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 5 of 10
Cristina Muñoz-Pinedo, Institut d'Investigacio Biomedica de Bellvitge, Spain
Short Talk: Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors


Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
This session is from Cell Death
Room: Concert Hall


Coffee Break


Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 7 of 10
Kim Newton, Genentech, Inc., USA
Regulation of Cell Death by RIPK1 and Caspase-8


Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 8 of 10
Kate Schroder, University of Queensland, Australia
Myeloid Cell Identity Shapes Inflammasome Signaling Pathways and Cell Death Decisions


Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 9 of 10
Jerome Estaquier, CHU de Québec Research Center Infectious Disease Research Center, Canada
Short Talk: Anti-apoptosis Agent Prevents AIDS


Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
This session is from Cell Death
Room: Concert Hall

Speaker 10 of 10
James M. Murphy, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Mechanistic Studies of How the Pseudokinase, MLKL, Is Activated and Kills Cells by Necroptosis


Friday, June 02 | 12:15PM - 5:00PM
On Own for Lunch


Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
Room: Hall 3

Speaker 1 of 10
* Martin Thurnher, Medical University of Innsbruck, Austria

Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
Room: Hall 3

Speaker 2 of 10
* Julian J. Lum, British Columbia Cancer Agency, Canada

Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
Room: Hall 3

Speaker 3 of 10
Jennifer Martinez, NIEHS, National Institutes of Health, USA
LC3-Associated Phagocytosis Links Efferocytosis to Inflammation and Metabolism

Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
Room: Hall 3

Speaker 4 of 10
Rianne G. J. W. van der Windt, Academic Medical Center, Netherlands
Impact of Signals from the Tumor Microenvironment on Chronic Lymphocytic Leukemia Metabolism

Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
Room: Hall 3

Speaker 5 of 10
Sagar P. Bapat, University of California, San Francisco, USA
PPARg Activation Suppresses Th2-Driven Atopic Disease via Metabolic Reprogramming

Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
Room: Hall 3

Speaker 6 of 10
Rafael de Queiroz Prado, NIAID, National Institutes of Health, USA
The L-Arginine Transporter Slc7a2 Regulates Asthma Pathogenesis by Inhibiting Inflammasome Activation in Non-Hematopoietic Cells

Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
Room: Hall 3

Speaker 7 of 10
Andrea J. Wolf, Cedars-Sinai Medical Center, USA
A Role for the Glycolytic Enzyme, Hexokinase, in Innate Immune Sensing by the NLRP3 Inflammasome

Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
Room: Hall 3

Speaker 8 of 10
Autumn G. York, Yale University, USA
Synthesis of Mono-Unsaturated Fatty Acids Negatively Regulates Inflammation

Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
Room: Hall 3

Speaker 9 of 10
Bin Zheng, Harvard Medical School, USA
Targeting Metabolic Vulnerabilities of MDSCs to Enhance the Anti-Tumor Activity of PD-1 Blockade

Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
Room: Hall 3

Speaker 10 of 10
Bart Everts, Leiden University Medical Center, Netherlands
LKB1 Expressed in Dendritic Cells Governs the Development of Thymus-Derived Regulatory T Cells

Friday, June 02 | 4:30PM - 5:00PM
Coffee Available
Room: Hall 4


Friday, June 02 | 5:00PM - 6:45PM
Microbiota Metabolism and Immune Cell Functions
Room: Hall 3

Speaker 1 of 4
* Laurence Morel, University of Florida, USA

Friday, June 02 | 5:00PM - 6:45PM
Microbiota Metabolism and Immune Cell Functions
Room: Hall 3

Speaker 2 of 4
Yasmine Belkaid, NIAID, National Institutes of Health, USA
White Adipose Tissue is a Hub for Memory T Cells and Promotes Memory Responses

Friday, June 02 | 5:00PM - 6:45PM
Microbiota Metabolism and Immune Cell Functions
Room: Hall 3

Speaker 3 of 4
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Immunometabolism

Friday, June 02 | 5:00PM - 6:45PM
Microbiota Metabolism and Immune Cell Functions
Room: Hall 3

Speaker 4 of 4
Daniel Mucida, Rockefeller University, USA
Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection


Friday, June 02 | 5:00PM - 6:00PM
Inflammation and Cancer
This session is from Cell Death
Room: Concert Hall

Speaker 1 of 3
* Peter Vandenabeele, VIB, Ghent University, Belgium


Friday, June 02 | 5:00PM - 6:00PM
Inflammation and Cancer
This session is from Cell Death
Room: Concert Hall

Speaker 2 of 3
Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
Inflammation in the Tumor Microenvironment


Friday, June 02 | 5:00PM - 6:00PM
Inflammation and Cancer
This session is from Cell Death
Room: Concert Hall

Speaker 3 of 3
Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Inflammatory Regulators and Cancer Progression


Friday, June 02 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Hall 3


Friday, June 02 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Cell Death
Room: Concert Hall


Friday, June 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Hall 4
No registration fees are used to fund alcohol served at this function.

Friday, June 02 | 8:00PM - 11:00PM
Special appearance for one night only - The Metabollix led b
y Luke O'Neill with special guests
Room: Hall 4
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources. Novo Nordisk A/S funding is not being used for this function.

Friday, June 02 | 8:00PM - 11:00PM
Cash Bar
Room: Hall 4


Saturday, June 03 | 10:25AM - 10:25AM
Departure


*Session Chair.