Web Desc
Neuroinflammation: Concepts, Characteristics, Consequences
Organizer(s): Richard M. Ransohoff, Christopher K. Glass and V. Hugh Perry
Date: June 19 - 23, 2017
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Biogen, BioLegend, Inc., Ionis Pharmaceuticals, Inc., Shire Human Genetic Therapies and Takeda Pharmaceutical Company Limited
Summary of Meeting:
Neuroinflammation comprises the interaction of two formidably complex organ systems. Two considerations motivate this meeting: first that the communities of neuroscientists and immunologists urgently need to formulate and deploy a joint set of concepts to promote mechanistic progress (hence a meeting of the two), and second that neuroinflammation, broadly conceived, operates throughout life from embryogenesis through old age with consequences bearing on the most serious health concerns ranging from autism and schizophrenia to dementia. What’s needed in this field (for example) is for immunologists to acquire a working knowledge of neuroscience (e.g., electrophysiology, neurotransmitters, behavior) and for neuroscientists to become comfortable with the cells, proteins and animating concepts of contemporary immunology. The optimal venue for such exchange lies in the presentation of compelling multidisciplinary research to a joint audience in the Keystone Symposia format. As such, this meeting aims to: 1) Integrate the intrinsic “immune” elements of the CNS (microglia, complement, certain chemokines) into a broader scheme of neurodevelopment and to indicate where aberrant function of these elements might conduce to neurodevelopmental disorders such as autism; 2) Characterize the neuroinflammatory processes which typify aging and integrate this temporal dynamic into the pathogenesis of neurodegenerative disease; and 3) Share model systems (particularly invertebrate) and technical innovations which can be particularly powerful for generating mechanistic insights into neuroinflammatory processes.
Scholarship Deadline: February 21 2017
Discounted Abstract Deadline: February 21 2017
Abstract Deadline: March 21 2017
Discounted Registration Deadline: April 19 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
BiogenBioLegend, Inc.Ionis Pharmaceuticals, Inc.ShireTakeda Pharmaceutical Company Limited
We gratefully acknowledge additional support for this conference from:
CEDARLANE
$10,000 - $24,999
NeuroscientistNews
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
American Association for the Advancement of Science (AAAS)American Association for the Advancement of Science (AAAS)
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, June 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Keystone Lodge Lobby


Monday, June 19 | 6:00PM - 8:00PM
Welcome Mixer
Room: Keystone Lodge-Bighorn Bar
No registration fees are used to fund alcohol served at this function.

Tuesday, June 20 | 7:30AM - 8:30AM
Breakfast
Room: Longs/Quandary Peaks


Tuesday, June 20 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 1 of 2
* Richard M. Ransohoff, Third Rock Ventures, USA

Tuesday, June 20 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 2 of 2
Christopher K. Glass, University of California, San Diego, USA
Delineation of an Environment-Dependent Transcriptional Network Specifying Human Microglia Identity

Tuesday, June 20 | 9:30AM - 11:30AM
Neuroinflammation and Ontogeny
Room: Grays Peak

Speaker 1 of 4
Richard M. Ransohoff, Third Rock Ventures, USA
Neuroinflammation: Historical Perspective and Overview

Tuesday, June 20 | 9:30AM - 11:30AM
Neuroinflammation and Ontogeny
Room: Grays Peak


Coffee Break

Tuesday, June 20 | 9:30AM - 11:30AM
Neuroinflammation and Ontogeny
Room: Grays Peak

Speaker 3 of 4
Marco Prinz, University of Freiburg, Germany
Myeloid Cell Activation and Kinetics in the Brain

Tuesday, June 20 | 9:30AM - 11:30AM
Neuroinflammation and Ontogeny
Room: Grays Peak

Speaker 4 of 4
Xianhua Piao, University of California San Francisco, USA
A GPCR Signaling triad: How Microglia Regulate Myelin Development and Repair

Tuesday, June 20 | 11:30AM - 2:30PM
On Own for Lunch


Tuesday, June 20 | 11:30AM - 1:00PM
Poster Setup
Room: Longs/Quandary Peaks


Tuesday, June 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs/Quandary Peaks


Tuesday, June 20 | 2:30PM - 4:30PM
Workshop: Microglial Profiles: Time for Your Close-Up!
Room: Grays Peak

Speaker 1 of 7
* Akihiko Koyama, Eisai Inc., USA

Tuesday, June 20 | 2:30PM - 4:30PM
Workshop: Microglial Profiles: Time for Your Close-Up!
Room: Grays Peak

Speaker 2 of 7
Stephen K. Amoah, University of New Mexico, USA
Effects of Maternal Immune Activation and Hypoxia on Schizophrenia-Related miRNA Expression

Tuesday, June 20 | 2:30PM - 4:30PM
Workshop: Microglial Profiles: Time for Your Close-Up!
Room: Grays Peak

Speaker 3 of 7
Clare Pridans, University of Edinburgh, UK
Csf1r Deficient Rats as a Model for Neurodegeneration

Tuesday, June 20 | 2:30PM - 4:30PM
Workshop: Microglial Profiles: Time for Your Close-Up!
Room: Grays Peak

Speaker 4 of 7
Stefka Gyoneva, Biogen, USA
Context-Dependent Effects of Cx3cr1 Deletion on Microglial Transcriptome

Tuesday, June 20 | 2:30PM - 4:30PM
Workshop: Microglial Profiles: Time for Your Close-Up!
Room: Grays Peak

Speaker 5 of 7
Vladimir Litvak, Sanofi US, USA
Systems Biology of Microglia Signaling in Neuroinflammation

Tuesday, June 20 | 2:30PM - 4:30PM
Workshop: Microglial Profiles: Time for Your Close-Up!
Room: Grays Peak

Speaker 6 of 7
Hansruedi Mathys, Massachusetts Institute of Technology, USA
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

Tuesday, June 20 | 2:30PM - 4:30PM
Workshop: Microglial Profiles: Time for Your Close-Up!
Room: Grays Peak

Speaker 7 of 7
Christopher Bohlen, Genentech, USA
Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-medium Cultures

Tuesday, June 20 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, June 20 | 5:00PM - 7:00PM
Glial Cells of the CNS: Glue No More
Room: Grays Peak

Speaker 1 of 4
* William S. Talbot, Stanford University School of Medicine, USA

Tuesday, June 20 | 5:00PM - 7:00PM
Glial Cells of the CNS: Glue No More
Room: Grays Peak

Speaker 2 of 4
Richard Daneman, University of California, San Diego, USA
Blood-Brain, Endothelial Cells and Pericytes

Tuesday, June 20 | 5:00PM - 7:00PM
Glial Cells of the CNS: Glue No More
Room: Grays Peak

Speaker 3 of 4
Brian Popko, University of Chicago, USA
Oligodendrocytes in the Pathogenesis of Multiple Sclerosis

Tuesday, June 20 | 5:00PM - 7:00PM
Glial Cells of the CNS: Glue No More
Room: Grays Peak

Speaker 4 of 4
Ethan G. Hughes, University of Colorado Anschutz Medical Campus, USA
Dynamics of NG2+ Glial Cells in the Resting and Damaged Brain

Tuesday, June 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks
No registration fees are used to fund alcohol served at this function.

Tuesday, June 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Longs/Quandary Peaks


Wednesday, June 21 | 7:30AM - 8:30AM
Breakfast
Room: Longs/Quandary Peaks


Wednesday, June 21 | 8:30AM - 11:30AM
Neuroinflammation: Phylogeny
Room: Grays Peak

Speaker 1 of 5
Magdalena Götz, University of Munich, Germany
Mechanism of Scar-Formation – From Zebrafish to Mammals

Wednesday, June 21 | 8:30AM - 11:30AM
Neuroinflammation: Phylogeny
Room: Grays Peak

Speaker 2 of 5
William S. Talbot, Stanford University School of Medicine, USA
Genetic Control of Microglia Development and Function in Zebrafish

Wednesday, June 21 | 8:30AM - 11:30AM
Neuroinflammation: Phylogeny
Room: Grays Peak


Coffee Break

Wednesday, June 21 | 8:30AM - 11:30AM
Neuroinflammation: Phylogeny
Room: Grays Peak

Speaker 4 of 5
David A. Wassarman, University of Wisconsin, USA
Neurodegeneration and Innate Immunity in Drosophila

Wednesday, June 21 | 8:30AM - 11:30AM
Neuroinflammation: Phylogeny
Room: Grays Peak

Speaker 5 of 5
Mary A. Logan, Oregon Health & Science University, USA
Genetic Investigation of Innate Glial Immune Responses in Drosophila

Wednesday, June 21 | 11:30AM - 5:00PM
On Own for Lunch


Wednesday, June 21 | 11:30AM - 1:00PM
Poster Setup
Room: Longs/Quandary Peaks


Wednesday, June 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs/Quandary Peaks


Wednesday, June 21 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, June 21 | 5:00PM - 7:00PM
Transgressions: Immune Molecules in the CNS and Vice Versa
Room: Grays Peak

Speaker 1 of 5
* Angela Vincent, University of Oxford, UK

Wednesday, June 21 | 5:00PM - 7:00PM
Transgressions: Immune Molecules in the CNS and Vice Versa
Room: Grays Peak

Speaker 2 of 5
Lisa M. Boulanger, Princeton University, USA
MHC Class I Immune Proteins in Neuronal Synaptic Transmission, Plasticity, and Disease

Wednesday, June 21 | 5:00PM - 7:00PM
Transgressions: Immune Molecules in the CNS and Vice Versa
Room: Grays Peak

Speaker 3 of 5
Wayne Drevets, Janssen R&D Pharmaceutical Companies of Johnson & Johnson, USA
IL6 and Treatment-Resistant Depression

Wednesday, June 21 | 5:00PM - 7:00PM
Transgressions: Immune Molecules in the CNS and Vice Versa
Room: Grays Peak

Speaker 4 of 5
Anzela Niraula, Ohio State University, USA
Short Talk: Corticosterone Mobilizes Monocytes into Circulation and Induces Endothelial Adhesion Molecule Expression to
Cause Monocyte Recruitment to the Brain during Stress


Wednesday, June 21 | 5:00PM - 7:00PM
Transgressions: Immune Molecules in the CNS and Vice Versa
Room: Grays Peak

Speaker 5 of 5
David V. Hansen, Genentech, Inc., USA
Short Talk: Debunking the Myth of Pro-Inflammatory Cytokines in Alzheimer’s Pathology, and Illuminating the Role of TREM2

Wednesday, June 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks
No registration fees are used to fund alcohol served at this function.

Wednesday, June 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Longs/Quandary Peaks


Thursday, June 22 | 7:30AM - 8:30AM
Breakfast
Room: Longs/Quandary Peaks


Thursday, June 22 | 8:30AM - 11:30AM
Some Real Immunology for a Change: B Cells and the CNS
Room: Grays Peak

Speaker 1 of 6
* Keiko Ozato, NICHD, National Institutes of Health, USA

Thursday, June 22 | 8:30AM - 11:30AM
Some Real Immunology for a Change: B Cells and the CNS
Room: Grays Peak

Speaker 2 of 6
Vanda A. Lennon, Mayo Clinic, USA
Neuromyelitis Optica (NMO): An Autoimmune Astrocytopathy

Thursday, June 22 | 8:30AM - 11:30AM
Some Real Immunology for a Change: B Cells and the CNS
Room: Grays Peak

Speaker 3 of 6
Amit Bar-Or, University of Pennsylvania, USA
Is MS not a T Cell-Mediated Disease?

Thursday, June 22 | 8:30AM - 11:30AM
Some Real Immunology for a Change: B Cells and the CNS
Room: Grays Peak


Coffee Break

Thursday, June 22 | 8:30AM - 11:30AM
Some Real Immunology for a Change: B Cells and the CNS
Room: Grays Peak

Speaker 5 of 6
Angela Vincent, University of Oxford, UK
Antibodies to Neuronal Receptors and Associated Proteins: Roles, Mechanisms and Challenges

Thursday, June 22 | 8:30AM - 11:30AM
Some Real Immunology for a Change: B Cells and the CNS
Room: Grays Peak

Speaker 6 of 6
Sara C. Brass, Dartmouth COllege, USA
Short Talk: Regulatory B Cell Induction by a Human Gut Commensal Antigen Protects Against CNS Inflammation and Demyelination

Thursday, June 22 | 11:30AM - 5:00PM
On Own for Lunch


Thursday, June 22 | 11:30AM - 1:00PM
Poster Setup
Room: Longs/Quandary Peaks


Thursday, June 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs/Quandary Peaks


Thursday, June 22 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, June 22 | 5:00PM - 7:15PM
Cool Stuff: New Techniques
Room: Grays Peak

Speaker 1 of 6
* Magdalena Götz, University of Munich, Germany

Thursday, June 22 | 5:00PM - 7:15PM
Cool Stuff: New Techniques
Room: Grays Peak

Speaker 2 of 6
Knut Biber, AbbVie Deutschland GmbH & Co. KG, Germany
Microglia-Replenished OHSC: A Culture System to Study in vivo-Like Adult Microglia

Thursday, June 22 | 5:00PM - 7:15PM
Cool Stuff: New Techniques
Room: Grays Peak

Speaker 3 of 6
Milos Pekny, University of Gothenburg, Sweden
3D Cultures: Letting Neural Cells Stretch Out and Breathe

Thursday, June 22 | 5:00PM - 7:15PM
Cool Stuff: New Techniques
Room: Grays Peak

Speaker 4 of 6
Akihiko Koyama, Eisai Inc., USA
Immunodementia: A Multidisciplinary Approach

Thursday, June 22 | 5:00PM - 7:15PM
Cool Stuff: New Techniques
Room: Grays Peak

Speaker 5 of 6
Carlo Condello, University of California, San Francisco, USA
Short Talk: Non-Invasive Bioluminescent Imaging of Astrocytic Gliosis Reveals Disease Progression and Drug Efficacy in Alzheimer's Mouse Models

Thursday, June 22 | 5:00PM - 7:15PM
Cool Stuff: New Techniques
Room: Grays Peak

Speaker 6 of 6
Carleton Goold, Novartis Institutes of Biomedical Research, USA
Short Talk: Gene-Edited Human Stem Cell Models of Tuberous Sclerosis Exhibit Treatable Disease Phenotypes upon 2D and 3D Neuronal Differentiation

Thursday, June 22 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks
No registration fees are used to fund alcohol served at this function.

Thursday, June 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Longs/Quandary Peaks


Friday, June 23 | 7:30AM - 8:30AM
Breakfast
Room: Longs/Quandary Peaks


Friday, June 23 | 8:30AM - 11:30AM
It's About Time: Neuroinflammation Across the Lifespan
Room: Grays Peak

Speaker 1 of 6
* Suman Jayadev, University of Washington, USA

Friday, June 23 | 8:30AM - 11:30AM
It's About Time: Neuroinflammation Across the Lifespan
Room: Grays Peak

Speaker 2 of 6
Staci Bilbo, Duke University, USA
Environmental Effects on Development Transduced through Neuroinflammation

Friday, June 23 | 8:30AM - 11:30AM
It's About Time: Neuroinflammation Across the Lifespan
Room: Grays Peak

Speaker 3 of 6
David Edwards, King's College London, UK
Neuroanatomical Effects of Prematurity

Friday, June 23 | 8:30AM - 11:30AM
It's About Time: Neuroinflammation Across the Lifespan
Room: Grays Peak


Coffee Break

Friday, June 23 | 8:30AM - 11:30AM
It's About Time: Neuroinflammation Across the Lifespan
Room: Grays Peak

Speaker 5 of 6
Edith Hamel, McGill University, Canada
Inflammation and Vascular Factors in Dementia

Friday, June 23 | 8:30AM - 11:30AM
It's About Time: Neuroinflammation Across the Lifespan
Room: Grays Peak

Speaker 6 of 6
Carina Block, Duke University, USA
Short Talk: Prenatal Air Pollution and Maternal Stress Alters Early Communication, Microglia and Synapse Number in Developing Offspring

Friday, June 23 | 11:30AM - 5:00PM
On Own for Lunch


Friday, June 23 | 2:30PM - 4:00PM
Panel: Looking Backwards and Forwards: Lessons Learned and S
uggestions for Improvement
Room: Grays Peak
This innovative panel discussion will be composed of and driven by postdocs and students. The panel will present their learnings (scientific and other) from the symposium, and provide suggestion to modify the format or content. Questions and comments from the audience will enrich the experience. Keystone Symposia staff will ensure these observations are considered for implementation at future conferences.
Speaker 1 of 1
* Richard M. Ransohoff, Third Rock Ventures, USA

Friday, June 23 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Friday, June 23 | 5:00PM - 6:45PM
Type I Interferon in CNS Physiology and Pathophysiology
Room: Grays Peak

Speaker 1 of 4
* Irene Knuesel, Roche Innovation Center Basel, Switzerland

Friday, June 23 | 5:00PM - 6:45PM
Type I Interferon in CNS Physiology and Pathophysiology
Room: Grays Peak

Speaker 2 of 4
V. Hugh Perry, University of Southampton, UK
Microglia, the Cornerstone of Neuroinflammation

Friday, June 23 | 5:00PM - 6:45PM
Type I Interferon in CNS Physiology and Pathophysiology
Room: Grays Peak

Speaker 3 of 4
Marina Lynch, Trinity College Dublin, Ireland
TLR2 Activation and its Effects on Hippocampal Function

Friday, June 23 | 5:00PM - 6:45PM
Type I Interferon in CNS Physiology and Pathophysiology
Room: Grays Peak

Speaker 4 of 4
Marcus Kaul, Sanford-Burnham Medical Research Institute, USA
Short Talk: Neuroprotection by IFNß in a Murine Model of HIV-1 Associated Brain Injury

Friday, June 23 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grays Peak


Friday, June 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks
No registration fees are used to fund alcohol served at this function.

Friday, June 23 | 8:00PM - 11:00PM
Entertainment
Room: Longs/Quandary Peaks
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, June 23 | 8:00PM - 11:00PM
Cash Bar
Room: Longs/Quandary Peaks


Saturday, June 24 | 10:25AM - 10:25AM
Departure


*Session Chair.