Web Desc
Diabetes
joint with Obesity and Adipose Tissue Biology
Organizer(s): Jiandie Lin, Clay F. Semenkovich and Rohit N. Kulkarni
Date: January 22 - 26, 2017
Location: Keystone Resort, Keystone, CO, USA
Sponsored by AstraZeneca, Journal of Molecular Cell Biology (JMCB) and Novo Nordisk A/S. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation.
Summary of Meeting:
Diabetes has reached alarming proportions worldwide, and the need for new therapies is great. Exercise and bariatric surgery are known to elicit profound metabolic benefits in type 2 diabetes, although the underlying mechanisms remain unclear. The possibility of altering metabolism through RNA-based therapies is also intriguing. This conference will bring together a diverse array of scientists from academia and industry, thereby facilitating knowledge exchange and interactions, leading to elucidation of better treatments. Joint sessions with the simultaneous conference on “Obesity and Adipose Tissue Biology” will create opportunities for synergies. Specifically, the conference will examine recent advances in understanding of brown/beige adipose tissue function; endocrine, paracrine and nutrient signaling; molecular mechanisms of metabolic signaling; emerging topics, including long noncoding RNA and the influence of the gut microbiome; and new approaches to drug development for treating diabetes and obesity.
Global Health Travel Award Deadline: August 23 2016
Scholarship Deadline: September 22 2016
Discounted Abstract Deadline: September 22 2016
Abstract Deadline: October 25 2016
Discounted Registration Deadline: November 22 2016
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZenecaBill & Melinda Gates FoundationJournal of Molecular Cell Biology (JMCB)Novo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
Journal of Lipid Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK104616-02
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK104616-03
Funding for this conference was made possible (in part) by 5R13DK104616-03 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 22 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, January 22 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Monday, January 23 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 1 of 5
* Jiandie Lin, University of Michigan Medical School, USA

Monday, January 23 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 2 of 5
* Marc L. Reitman, NIDDK, National Institutes of Health, USA

Monday, January 23 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 3 of 5
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Journal of Lipid Research Lectureship: Adipose Origin and Expansion

Monday, January 23 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 4 of 5
Richard D. DiMarchi, Indiana University and Novo Nordisk, USA
Chemical Biotechnology Applied to Metabolic Diseases

Monday, January 23 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom


Coffee Break

Monday, January 23 | 9:50AM - 12:15PM
Brown/Beige Fat Activation and Function (Joint)
Room: Columbine Ballroom

Speaker 1 of 5
* Antonio J. Vidal-Puig, University of Cambridge, UK

Monday, January 23 | 9:50AM - 12:15PM
Brown/Beige Fat Activation and Function (Joint)
Room: Columbine Ballroom

Speaker 2 of 5
Jan Nedergaard, Stockholm University, Sweden
Brown Adipose Physiology

Monday, January 23 | 9:50AM - 12:15PM
Brown/Beige Fat Activation and Function (Joint)
Room: Columbine Ballroom

Speaker 3 of 5
Aaron M. Cypess, NIDDK, National Institutes of Health, USA
Activation of Brown Adipose Tissue in Humans

Monday, January 23 | 9:50AM - 12:15PM
Brown/Beige Fat Activation and Function (Joint)
Room: Columbine Ballroom

Speaker 4 of 5
Ajay Chawla, Merck Research Labs, USA
Innate Immune Licensing of Thermogenesis

Monday, January 23 | 9:50AM - 12:15PM
Brown/Beige Fat Activation and Function (Joint)
Room: Columbine Ballroom

Speaker 5 of 5
Patrick Seale, University of Pennsylvania, USA
Regulators of Brown and Beige Fat Activity

Monday, January 23 | 12:15PM - 2:30PM
On Own for Lunch


Monday, January 23 | 12:15PM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Monday, January 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Monday, January 23 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Development in Obesity (Joint)
Room: Grays/Long Peak

Speaker 1 of 9
* Bei Shan, Lilly China Research and Development Center, China

Monday, January 23 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Development in Obesity (Joint)
Room: Grays/Long Peak

Speaker 2 of 9
Michelle L. Boland, Medimmune, USA
MEDI0382, a Dual GLP-1/Glucagon Receptor Agonist, is More Effective on Alleviating Non-Alcoholic Steatohepatitis (NASH) Compared to Liraglutide in a Mouse Model of NASH

Monday, January 23 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Development in Obesity (Joint)
Room: Grays/Long Peak

Speaker 3 of 9
Andrea Galmozzi, The Scripps Research Institute, USA
Chemoproteomics-driven Discovery of PGRMC2 as a New Regulator of Adipocyte Physiology with Therapeutic Potential in Obesity-Linked Diabetes

Monday, January 23 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Development in Obesity (Joint)
Room: Grays/Long Peak

Speaker 4 of 9
Hua V. Lin, BioFront Therapeutics, China
GPR142 Agonists Improve Beta Cell Proliferation and Survival

Monday, January 23 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Development in Obesity (Joint)
Room: Grays/Long Peak

Speaker 5 of 9
Kfir Sharabi, Dana-Farber Cancer Institute, USA
Small Molecule Screen Identifies Selective PGC-1alpha Gluconeogenic Inhibitors that Ameliorate Diabetic Symptoms

Monday, January 23 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Development in Obesity (Joint)
Room: Grays/Long Peak

Speaker 6 of 9
Cholsoon Jang, Princeton University, USA
A Metabolite of Branched Chain Amino Acids Drives Vascular Fatty Acid Transport and Insulin Resistance

Monday, January 23 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Development in Obesity (Joint)
Room: Grays/Long Peak

Speaker 7 of 9
Zheng Sun, Baylor College of Medicine, USA
Dissociation of Muscle Glucose Utilization from Exercise Endurance by Circadian Epigenomic Regulator HDAC3

Monday, January 23 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Development in Obesity (Joint)
Room: Grays/Long Peak

Speaker 8 of 9
Jonathan Z. Long, Dana-Farber Cancer Institute, USA
The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria

Monday, January 23 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Development in Obesity (Joint)
Room: Grays/Long Peak

Speaker 9 of 9
Nicolai Jacob Wewer Albrechtsen, University of Copenhagen, Denmark
An Insulinotropic Glucagon Variant Identified in Man

Monday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 23 | 5:00PM - 7:00PM
Exercise and Type 2 Diabetes
Room: Quandary Peak

Speaker 1 of 5
* Clay F. Semenkovich, Washington University School of Medicine, USA

Monday, January 23 | 5:00PM - 7:00PM
Exercise and Type 2 Diabetes
Room: Quandary Peak

Speaker 2 of 5
Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA
Exercise Regulation of Adipose Tissue

Monday, January 23 | 5:00PM - 7:00PM
Exercise and Type 2 Diabetes
Room: Quandary Peak

Speaker 3 of 5
Juleen R. Zierath, Karolinska Institutet, Sweden
The Role of Diet and Exercise in the Epigenetic Landscape of Type 2 Diabetes

Monday, January 23 | 5:00PM - 7:00PM
Exercise and Type 2 Diabetes
Room: Quandary Peak

Speaker 4 of 5
Christoph Handschin, University of Basel, Switzerland
Regulation of Physiological and Dietary Ketone Body Homeostasis and Diabetic Hyperketosis by Muscle PGC-1alpha and Exercise

Monday, January 23 | 5:00PM - 7:00PM
Exercise and Type 2 Diabetes
Room: Quandary Peak

Speaker 5 of 5
Xingxing Kong, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Short Talk: Brown Fat Dysfunction Induces Skeletal Muscle Myopathy via an IRF4-Myostatin-Mediated Pathway

Monday, January 23 | 5:00PM - 7:15PM
Adipose Tissue Development
This session is from Obesity
Room: Grays/Longs Peak

Speaker 1 of 6
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA


Monday, January 23 | 5:00PM - 7:15PM
Adipose Tissue Development
This session is from Obesity
Room: Grays/Longs Peak

Speaker 2 of 6
Evan D. Rosen, Harvard University, USA
Insights from the Epigenomic Analysis of Human and Murine Adipose Tissue


Monday, January 23 | 5:00PM - 7:15PM
Adipose Tissue Development
This session is from Obesity
Room: Grays/Longs Peak

Speaker 3 of 6
Christian Wolfrum, ETH Zürich, Switzerland
Adipose Tissue Stem Cells


Monday, January 23 | 5:00PM - 7:15PM
Adipose Tissue Development
This session is from Obesity
Room: Grays/Longs Peak

Speaker 4 of 6
Silvia Corvera, University of Massachusetts Medical School, USA
Origin and Function of Human Brite/Beige Adipocytes


Monday, January 23 | 5:00PM - 7:15PM
Adipose Tissue Development
This session is from Obesity
Room: Grays/Longs Peak

Speaker 5 of 6
Zachary Sebo, Yale University, USA
Short Talk: A Sexually Dimorphic Mesodermal Fate Map for Adipose Tissue


Monday, January 23 | 5:00PM - 7:15PM
Adipose Tissue Development
This session is from Obesity
Room: Grays/Longs Peak

Speaker 6 of 6
Rana K. Gupta, University of Texas Southwestern Medical Center, USA
Short Talk: Visceral Adipocyte Differentiation from Mural Adipose Precursors Protects Against Pathological Adipose Tissue Expansion and Insulin Resistance in Obesity


Monday, January 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, January 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Colorado Rockies Ballroom


Tuesday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Tuesday, January 24 | 8:00AM - 11:15AM
Interorgan Metabolic Crosstalk via Secreted Factors (Joint)
Room: Columbine Ballroom

Speaker 1 of 8
* Christoph Handschin, University of Basel, Switzerland

Tuesday, January 24 | 8:00AM - 11:15AM
Interorgan Metabolic Crosstalk via Secreted Factors (Joint)
Room: Columbine Ballroom

Speaker 2 of 8
Takashi Kadowaki, University of Tokyo, Japan
Adiponectin Receptors: A Major Treatment Target in Type 2 Diabetes and Obesity-Linked Diseases

Tuesday, January 24 | 8:00AM - 11:15AM
Interorgan Metabolic Crosstalk via Secreted Factors (Joint)
Room: Columbine Ballroom

Speaker 3 of 8
Jiandie Lin, University of Michigan Medical School, USA
The Brown Fat Secretome: Metabolic Functions Beyond Thermogenesis

Tuesday, January 24 | 8:00AM - 11:15AM
Interorgan Metabolic Crosstalk via Secreted Factors (Joint)
Room: Columbine Ballroom


Coffee Break

Tuesday, January 24 | 8:00AM - 11:15AM
Interorgan Metabolic Crosstalk via Secreted Factors (Joint)
Room: Columbine Ballroom

Speaker 5 of 8
David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
The Diverse Metabolic Actions of FGF21

Tuesday, January 24 | 8:00AM - 11:15AM
Interorgan Metabolic Crosstalk via Secreted Factors (Joint)
Room: Columbine Ballroom

Speaker 6 of 8
Yonghao Yu, University of Texas Southwestern Medical Center, USA
Large Scale Proteomic Analysis Identifies IGFBP5 as a Secreted mTORC1 Target that Mediates mTORC1-Dependent Feedback Inhibition of IGF-1 Signaling

Tuesday, January 24 | 8:00AM - 11:15AM
Interorgan Metabolic Crosstalk via Secreted Factors (Joint)
Room: Columbine Ballroom

Speaker 7 of 8
Russell A. Miller, Pfizer Inc., USA
Short Talk: Glucagon Stimulates Hepatic Glutamine Utilization by Increasing Metabolic Flux through GLS2

Tuesday, January 24 | 8:00AM - 11:15AM
Interorgan Metabolic Crosstalk via Secreted Factors (Joint)
Room: Columbine Ballroom

Speaker 8 of 8
Lucas BonDurant, Alnylam Pharmaceuticals, USA
Short Talk: FGF21 Signals Directly to Adipose Tissues to Acutely Enhance Insulin Sensitivity

Tuesday, January 24 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, January 24 | 11:15AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Tuesday, January 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Tuesday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 24 | 5:00PM - 7:00PM
Long Noncoding and MicroRNAs and Metabolism
Room: Quandary Peak

Speaker 1 of 5
* Jiandie Lin, University of Michigan Medical School, USA

Tuesday, January 24 | 5:00PM - 7:00PM
Long Noncoding and MicroRNAs and Metabolism
Room: Quandary Peak

Speaker 2 of 5
Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Non-Coding Gene Regulation of the Pancreatic Islet

Tuesday, January 24 | 5:00PM - 7:00PM
Long Noncoding and MicroRNAs and Metabolism
Room: Quandary Peak

Speaker 3 of 5
Lei Sun, Duke-NUS Graduate Medical School Singapore, Singapore
Regulatory Role of Long Noncoding RNAs in Adipose


Tuesday, January 24 | 5:00PM - 7:00PM
Long Noncoding and MicroRNAs and Metabolism
Room: Quandary Peak

Speaker 4 of 5
Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
A Role for MicroRNAs in Diabetes and Its Complications

Tuesday, January 24 | 5:00PM - 7:00PM
Long Noncoding and MicroRNAs and Metabolism
Room: Quandary Peak

Speaker 5 of 5
Congcong He, Northwestern University, USA
Short Talk: Differential Roles of Autophagy in Insulin Production and Sensitivity

Tuesday, January 24 | 5:00PM - 7:15PM
Adipose Inflammation; Adipokines
This session is from Obesity
Room: Grays/Longs Peak

Speaker 1 of 6
* Ajay Chawla, Merck Research Labs, USA


Tuesday, January 24 | 5:00PM - 7:15PM
Adipose Inflammation; Adipokines
This session is from Obesity
Room: Grays/Longs Peak

Speaker 2 of 6
Ruth E. Gimeno, Eli Lilly and Company, USA
Pharmacological Approaches to Adipose Tissue Function


Tuesday, January 24 | 5:00PM - 7:15PM
Adipose Inflammation; Adipokines
This session is from Obesity
Room: Grays/Longs Peak

Speaker 3 of 6
Anthony W. Ferrante, Columbia University, USA
Induction of Adipose Tissue Inflammation


Tuesday, January 24 | 5:00PM - 7:15PM
Adipose Inflammation; Adipokines
This session is from Obesity
Room: Grays/Longs Peak

Speaker 4 of 6
Alyssa H. Hasty, Vanderbilt University, USA
Macrophages as Adipose Tissue 'Ferrostats'


Tuesday, January 24 | 5:00PM - 7:15PM
Adipose Inflammation; Adipokines
This session is from Obesity
Room: Grays/Longs Peak

Speaker 5 of 6
Prashant Rajbhandari, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Interleukin-10 Signaling Alters Chromatin Architecture in Adipose to Regulate Thermogenesis and Energy Expenditure


Tuesday, January 24 | 5:00PM - 7:15PM
Adipose Inflammation; Adipokines
This session is from Obesity
Room: Grays/Longs Peak

Speaker 6 of 6
Min Jeong Choi, Chungnam National University, South Korea
Short Talk: Secretory Factors Induced by Adipocyte Mitochondrial OxPhos Dysfunction Modulate Systemic Metabolism by Influencing the Adipose Immune Environment


Tuesday, January 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, January 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Colorado Rockies Ballroom


Wednesday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Wednesday, January 25 | 8:00AM - 11:15AM
Gut Microbiome and Bariatric Surgery (Joint)
Room: Columbine Ballroom

Speaker 1 of 7
Patrice D. Cani, Université Catholique de Louvain, Belgium
Specific Gut Microbiota and Intestinal Sensors: Focus on Novel Mechanisms Affecting Glucose and Energy Metabolism

Wednesday, January 25 | 8:00AM - 11:15AM
Gut Microbiome and Bariatric Surgery (Joint)
Room: Columbine Ballroom

Speaker 2 of 7
* Randy J. Seeley, University of Michigan, USA
Gut Endocrine Signaling in Bariatric Surgery

Wednesday, January 25 | 8:00AM - 11:15AM
Gut Microbiome and Bariatric Surgery (Joint)
Room: Columbine Ballroom


Coffee Break

Wednesday, January 25 | 8:00AM - 11:15AM
Gut Microbiome and Bariatric Surgery (Joint)
Room: Columbine Ballroom

Speaker 4 of 7
Helen Raybould, University of California, Davis, USA
The Microbiota-Gut-Brain Axis in the Control of Food Intake and Body Weight

Wednesday, January 25 | 8:00AM - 11:15AM
Gut Microbiome and Bariatric Surgery (Joint)
Room: Columbine Ballroom

Speaker 5 of 7
Fredrik Bäckhed, University of Gothenburg, Sweden
Does Altered Gut Microbiome after Bariatric Surgery Contribute to Improved Metabolism?

Wednesday, January 25 | 8:00AM - 11:15AM
Gut Microbiome and Bariatric Surgery (Joint)
Room: Columbine Ballroom

Speaker 6 of 7
Jantje M. Gerdes, Helmholtz Zentrum München, Germany
Short Talk: EphA/ephrin Signaling in Pancreatic Islets is Regulated by Primary Cilia

Wednesday, January 25 | 8:00AM - 11:15AM
Gut Microbiome and Bariatric Surgery (Joint)
Room: Columbine Ballroom

Speaker 7 of 7
Chieh Jason Chou, Nestlé Institute of Health Sciences SA, Switzerland
Short Talk: The Effect of Diets on the Metabolic Benefits Associated with Post Bariatric Surgery Microbiota

Wednesday, January 25 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, January 25 | 11:15AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Wednesday, January 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Wednesday, January 25 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 25 | 5:00PM - 7:00PM
Substrate Flux and Metabolic Signaling
Room: Quandary Peak

Speaker 1 of 5
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Wednesday, January 25 | 5:00PM - 7:00PM
Substrate Flux and Metabolic Signaling
Room: Quandary Peak

Speaker 2 of 5
Clay F. Semenkovich, Washington University School of Medicine, USA
Lipid-Mediated Metabolic Signaling

Wednesday, January 25 | 5:00PM - 7:00PM
Substrate Flux and Metabolic Signaling
Room: Quandary Peak

Speaker 3 of 5
Gerald I. Shulman, Yale University School of Medicine, USA
Role of Hepatic Acetyl CoA in the Regulation of Hepatic Gluconeogenesis in Normal and Diabetic States


Wednesday, January 25 | 5:00PM - 7:00PM
Substrate Flux and Metabolic Signaling
Room: Quandary Peak

Speaker 4 of 5
Christopher B. Newgard, Duke University Medical Center, USA
Metabolic Flux and Homeostais

Wednesday, January 25 | 5:00PM - 7:00PM
Substrate Flux and Metabolic Signaling
Room: Quandary Peak

Speaker 5 of 5
Hongyuan Yang, University of New South Wales, Australia
Short Talk: Understanding Congenital Generalized Lipodystrophy

Wednesday, January 25 | 5:00PM - 7:15PM
Neural Control of Adipose/Adipose Function
This session is from Obesity
Room: Grays/Longs Peak

Speaker 1 of 6
* Jan Nedergaard, Stockholm University, Sweden


Wednesday, January 25 | 5:00PM - 7:15PM
Neural Control of Adipose/Adipose Function
This session is from Obesity
Room: Grays/Longs Peak

Speaker 2 of 6
Heike Münzberg, Pennington Biomedical Research Center, USA
Central Circuits of Thermoregulatory Leptin Action


Wednesday, January 25 | 5:00PM - 7:15PM
Neural Control of Adipose/Adipose Function
This session is from Obesity
Room: Grays/Longs Peak

Speaker 3 of 6
Rudolf Zechner, University of Graz, Austria
Adipose Triglyceride Lipase


Wednesday, January 25 | 5:00PM - 7:15PM
Neural Control of Adipose/Adipose Function
This session is from Obesity
Room: Grays/Longs Peak

Speaker 4 of 6
Joerg Heeren, University Medical Center Hamburg-Eppendorf, Germany
Brown Fat and Lipid Metabolism


Wednesday, January 25 | 5:00PM - 7:15PM
Neural Control of Adipose/Adipose Function
This session is from Obesity
Room: Grays/Longs Peak

Speaker 5 of 6
Peter K. Jackson, Stanford University, USA
Short Talk: Linking Monogenic and Complex Obesity to Primary Cilia: The Cep19 Obesity Protein Regulates a Conserved GTPase Cycle Coupling Cargo to the IFT-B Complex for Ciliary Transport of the BBSome and GPCRs


Wednesday, January 25 | 5:00PM - 7:15PM
Neural Control of Adipose/Adipose Function
This session is from Obesity
Room: Grays/Longs Peak

Speaker 6 of 6
Qi Wu, Baylor College of Medicine, USA
Short Talk: Deciphering an AgRP-Dorsal Raphe Neural Circuit in Exclusive Control of Energy Expenditure


Wednesday, January 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, January 25 | 7:30PM - 10:00PM
Poster Session 3
Room: Colorado Rockies Ballroom


Thursday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Thursday, January 26 | 8:00AM - 11:15AM
Mechanisms of Nutrient Signaling
Room: Quandary Peak

Speaker 1 of 8
* Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA

Thursday, January 26 | 8:00AM - 11:15AM
Mechanisms of Nutrient Signaling
Room: Quandary Peak

Speaker 2 of 8
Antonio J. Vidal-Puig, University of Cambridge, UK
Adipose Tissue Expandability, Lipotoxicity and the Metabolic Syndrome


Thursday, January 26 | 8:00AM - 11:15AM
Mechanisms of Nutrient Signaling
Room: Quandary Peak

Speaker 3 of 8
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Metabolic Signaling in Physiology and Disease

Thursday, January 26 | 8:00AM - 11:15AM
Mechanisms of Nutrient Signaling
Room: Quandary Peak


Coffee Break

Thursday, January 26 | 8:00AM - 11:15AM
Mechanisms of Nutrient Signaling
Room: Quandary Peak

Speaker 5 of 8
Hei Sook Sul, University of California, Berkeley, USA
Regulation of Fat Metabolism

Thursday, January 26 | 8:00AM - 11:15AM
Mechanisms of Nutrient Signaling
Room: Quandary Peak

Speaker 6 of 8
Jun Wu, University of Michigan, USA
Beige-Fat-Specific Regulation in Mouse and Human

Thursday, January 26 | 8:00AM - 11:15AM
Mechanisms of Nutrient Signaling
Room: Quandary Peak

Speaker 7 of 8
Feng Liu, University of Texas Health Science Center, USA
Short Talk: DsbA-L Suppresses Inflammation and Promotes Beiging and Thermogenesis by Improving Mitochondrial Function

Thursday, January 26 | 8:00AM - 11:15AM
Mechanisms of Nutrient Signaling
Room: Quandary Peak

Speaker 8 of 8
Adilson L. Guilherme, University of Massachusetts Medical School, USA
Short Talk: Suppression of Adipocyte Fatty Acid Synthase in Adult Mice Enhances Adipose Sympathetic Activity and Browning to Improve Glucose Homeostasis in Obese Mice

Thursday, January 26 | 8:00AM - 11:00AM
Genetics and Systems Biology
This session is from Obesity
Room: Grays/Longs Peak

Speaker 1 of 7
* Evan D. Rosen, Harvard University, USA


Thursday, January 26 | 8:00AM - 11:00AM
Genetics and Systems Biology
This session is from Obesity
Room: Grays/Longs Peak

Speaker 2 of 7
Umut Ozcan, Harvard Medical School, USA
Role of Endoplasmic Reticulum Stress in Development of Obesity and Type 2 Diabetes


Thursday, January 26 | 8:00AM - 11:00AM
Genetics and Systems Biology
This session is from Obesity
Room: Grays/Longs Peak

Speaker 3 of 7
Ruth J.F. Loos, Mount Sinai School of Medicine, USA
The Genetics of Obesity - Going Beyond Common Variation and Common Phenotypes


Thursday, January 26 | 8:00AM - 11:00AM
Genetics and Systems Biology
This session is from Obesity
Room: Grays/Longs Peak


Coffee Break


Thursday, January 26 | 8:00AM - 11:00AM
Genetics and Systems Biology
This session is from Obesity
Room: Grays/Longs Peak

Speaker 5 of 7
Jose C. Florez, Massachusetts General Hospital, USA
Pharmacogenetics of Type 2 Diabetes


Thursday, January 26 | 8:00AM - 11:00AM
Genetics and Systems Biology
This session is from Obesity
Room: Grays/Longs Peak

Speaker 6 of 7
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Transcriptional Regulation of Metabolism


Thursday, January 26 | 8:00AM - 11:00AM
Genetics and Systems Biology
This session is from Obesity
Room: Grays/Longs Peak

Speaker 7 of 7
Yi Chen, Dana-Farber Cancer Institute, USA
Short Talk: Potassium Current Through KCNK3 Regulates Brown Adipose Thermogenesis and Obesity


Thursday, January 26 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Metabolic Regulation in Physiology and Disease
Room: Quandary Peak

Speaker 1 of 9
* Dave Bridges, University of Michigan, USA

Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Metabolic Regulation in Physiology and Disease
Room: Quandary Peak

Speaker 2 of 9
Constanza J. Cortes Rodriguez, University of Alabama at Birmingham, USA
Skeletal Muscle Control of Systemic Metabolism: A Role for Transcription Factor E-B (TFEB) Signaling

Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Metabolic Regulation in Physiology and Disease
Room: Quandary Peak

Speaker 3 of 9
Zhuoxian Meng, University of Michigan, USA
Glucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis

Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Metabolic Regulation in Physiology and Disease
Room: Quandary Peak

Speaker 4 of 9
Tiemin Liu, University of Texas Southwestern Medical Center, USA
5-HT2C Receptors in Brainstem Neurons Regulate Glucose Homeostasis

Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Metabolic Regulation in Physiology and Disease
Room: Quandary Peak

Speaker 5 of 9
Fajun Yang, Albert Einstein College of Medicine, USA
Cyclin C Regulates Brown Fat Development and Function

Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Metabolic Regulation in Physiology and Disease
Room: Quandary Peak

Speaker 6 of 9
Yanhui Zhang, University of Iowa, USA
SWELL1 is a Regulator of Adipocyte Size, Insulin Signaling and Glucose Homeostasis

Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Metabolic Regulation in Physiology and Disease
Room: Quandary Peak

Speaker 7 of 9
Andrew C. Shin, Texas Tech University, USA
Insulin Receptor Signaling in POMC, but not AgRP, Neurons Controls Adipose Tissue Insulin Action

Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Metabolic Regulation in Physiology and Disease
Room: Quandary Peak

Speaker 8 of 9
Jakob G. Knudsen, University of Oxford, UK
Glucagon Secretion is Dependent on Alpha-Cell Fatty Acid Oxidation

Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Metabolic Regulation in Physiology and Disease
Room: Quandary Peak

Speaker 9 of 9
Meilian Liu, University of New Mexico Health Sciences Center, USA
Adipose mTORC1 Suppresses Beige Fat Development via Autophagy-Dependent Mechanisms

Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Adipose Thermogenesis and a Little Bit More
This session is from Obesity
Room: Grays/Longs Peak

Speaker 1 of 10
* Barbara Cannon, Stockholm University, Sweden


Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Adipose Thermogenesis and a Little Bit More
This session is from Obesity
Room: Grays/Longs Peak

Speaker 2 of 10
* Matthias Blüher, University of Leipzig, Germany


Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Adipose Thermogenesis and a Little Bit More
This session is from Obesity
Room: Grays/Longs Peak

Speaker 3 of 10
Erin L. Brown, Johns Hopkins Medical Institute, USA
Regulation of Adipose Tissue Thermogenic Capacity by Estrogen-Related Receptors


Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Adipose Thermogenesis and a Little Bit More
This session is from Obesity
Room: Grays/Longs Peak

Speaker 4 of 10
Shunbun Kita, Graduate School of Medicine, Osaka University, Japan
Adiponectin/T-Cadherin System Regulates Exosome Biogenesis and Systemic Plasma Exosome Level


Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Adipose Thermogenesis and a Little Bit More
This session is from Obesity
Room: Grays/Longs Peak

Speaker 5 of 10
Pegah Poursharifi, University of Montreal-CRCHUM, Canada
ABHD6 Negatively Regulates Thermogenic Adaptive Responses under Cold Stress


Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Adipose Thermogenesis and a Little Bit More
This session is from Obesity
Room: Grays/Longs Peak

Speaker 6 of 10
Pingwen Xu, Baylor College of Medicine, USA
Ventral Medial Hypothalamus ERalpha Neurocircuits in the Regulation of Thermogenesis and Physical Activity


Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Adipose Thermogenesis and a Little Bit More
This session is from Obesity
Room: Grays/Longs Peak

Speaker 7 of 10
Ludger Scheja, University Medical Center Hamburg-Eppendorf, Germany
Carbohydrate Response Element Binding Protein Regulates de novo Lipogenesis in Brown Adipose Tissue and Adaptive thermogenesis


Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Adipose Thermogenesis and a Little Bit More
This session is from Obesity
Room: Grays/Longs Peak

Speaker 8 of 10
Roland H. Stimson, University of Edinburgh, UK
Direct Measurement of in vivo Substrate Utilisation by Human Brown Adipose Tissue


Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Adipose Thermogenesis and a Little Bit More
This session is from Obesity
Room: Grays/Longs Peak

Speaker 9 of 10
Claudio J. Villanueva, University of California, Los Angeles, USA
Global Analysis of Plasma Lipids Identifies Liver-Derived Acyl-Carnitines as a Fuel Source for Brown Fat Thermogenesis


Thursday, January 26 | 2:30PM - 4:30PM
Workshop 2: Adipose Thermogenesis and a Little Bit More
This session is from Obesity
Room: Grays/Longs Peak

Speaker 10 of 10
Mary N. Teruel, Stanford University, USA
Transcription Factor Dynamics Define a Circadian Code for Fat Cell Differentiation


Thursday, January 26 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 26 | 5:00PM - 6:45PM
Emerging Topics in Diabetes
Room: Quandary Peak

Speaker 1 of 4
* Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA

Thursday, January 26 | 5:00PM - 6:45PM
Emerging Topics in Diabetes
Room: Quandary Peak

Speaker 2 of 4
Stephan Kissler, Joslin Diabetes Center, USA
Immune Dysregulation Underlying Type 1 Diabetes

Thursday, January 26 | 5:00PM - 6:45PM
Emerging Topics in Diabetes
Room: Quandary Peak

Speaker 3 of 4
Ralph A. DeFronzo, University of Texas Health Sciences Center at San Antonio, USA
The Kidney and Glucose Homeostasis: Implications for Therapy

Thursday, January 26 | 5:00PM - 6:45PM
Emerging Topics in Diabetes
Room: Quandary Peak

Speaker 4 of 4
Jayne S. Danska, Hospital for Sick Children Research Institute, Canada
Diabetes Trialog: Genes, Sex and the Microbiome

Thursday, January 26 | 5:00PM - 7:15PM
Treatment of Obesity
This session is from Obesity
Room: Grays/Longs Peak

Speaker 1 of 6
* Ruth E. Gimeno, Eli Lilly and Company, USA


Thursday, January 26 | 5:00PM - 7:15PM
Treatment of Obesity
This session is from Obesity
Room: Grays/Longs Peak

Speaker 2 of 6
Steven R. Smith, AdventHealth, USA
Clinical Obesity Treatment - Quantitative Bioenergetics


Thursday, January 26 | 5:00PM - 7:15PM
Treatment of Obesity
This session is from Obesity
Room: Grays/Longs Peak

Speaker 3 of 6
Matthias Blüher, University of Leipzig, Germany
New Developments in Treatment of Obesity


Thursday, January 26 | 5:00PM - 7:15PM
Treatment of Obesity
This session is from Obesity
Room: Grays/Longs Peak

Speaker 4 of 6
Marc L. Reitman, NIDDK, National Institutes of Health, USA
Role of Body and Environmental Temperature in Energy Homeostasis and Drug Development


Thursday, January 26 | 5:00PM - 7:15PM
Treatment of Obesity
This session is from Obesity
Room: Grays/Longs Peak

Speaker 5 of 6
Denis P. Blondin, University of Sherbrooke, Canada
Short Talk: The Use of a Beta3-Adrenergic Receptor Agonist in Humans Stimulates BAT Glucose Disposal, but not Thermogenesis


Thursday, January 26 | 5:00PM - 7:15PM
Treatment of Obesity
This session is from Obesity
Room: Grays/Longs Peak

Speaker 6 of 6
Minna Lahesmaa, Turku PET Centre, Finland
Short Talk: Cannabinoid CB1 Receptors in Human Brown Adipose Tissue during Cold Exposure


Thursday, January 26 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Quandary Peak

Speaker 1 of 1
* Clay F. Semenkovich, Washington University School of Medicine, USA

Thursday, January 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, January 26 | 7:15PM - 7:30PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Obesity
Room: Grays/Longs Peak


Thursday, January 26 | 8:00PM - 11:00PM
Entertainment
Room: Colorado Rockies Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources. Novo Nordisk A/S funding is not being used for this function.

Thursday, January 26 | 8:00PM - 11:00PM
Cash Bar
Room: Colorado Rockies Ballroom


Friday, January 27 | 10:25AM - 10:25AM
Departure


*Session Chair.