Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
	Diabetes: Glucose Control and Beyond (2020J5)
Diabetes: Innovations, Outcomes and Personalized Therapies (2019X3)
Drivers of Type 2 Diabetes: From Genes to Environment (2019S1)

Web Desc
Diabetes joint with Obesity and Adipose Tissue Biology Organizer(s): Jiandie Lin, Clay F. Semenkovich and Rohit N. Kulkarni Date: January 22 - 26, 2017 Location: Keystone Resort, Keystone, CO, USA Sponsored by AstraZeneca, Journal of Molecular Cell Biology (JMCB) and Novo Nordisk A/S. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation. Summary of Meeting: Diabetes has reached alarming proportions worldwide, and the need for new therapies is great. Exercise and bariatric surgery are known to elicit profound metabolic benefits in type 2 diabetes, although the underlying mechanisms remain unclear. The possibility of altering metabolism through RNA-based therapies is also intriguing. This conference will bring together a diverse array of scientists from academia and industry, thereby facilitating knowledge exchange and interactions, leading to elucidation of better treatments. Joint sessions with the simultaneous conference on “Obesity and Adipose Tissue Biology” will create opportunities for synergies. Specifically, the conference will examine recent advances in understanding of brown/beige adipose tissue function; endocrine, paracrine and nutrient signaling; molecular mechanisms of metabolic signaling; emerging topics, including long noncoding RNA and the influence of the gut microbiome; and new approaches to drug development for treating diabetes and obesity. Global Health Travel Award Deadline: August 23 2016 Scholarship Deadline: September 22 2016 Discounted Abstract Deadline: September 22 2016 Abstract Deadline: October 25 2016 Discounted Registration Deadline: November 22 2016 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Grant No. 5R13DK104616-02 The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Grant No. 5R13DK104616-03 Funding for this conference was made possible (in part) by 5R13DK104616-03 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Diabetes

joint with Obesity and Adipose Tissue Biology

Organizer(s): Jiandie Lin, Clay F. Semenkovich and Rohit N. Kulkarni

Date: January 22 - 26, 2017
Location: Keystone Resort, Keystone, CO, USA

Sponsored by AstraZeneca, Journal of Molecular Cell Biology (JMCB) and Novo Nordisk A/S. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation.

Summary of Meeting:

Diabetes has reached alarming proportions worldwide, and the need for new therapies is great. Exercise and bariatric surgery are known to elicit profound metabolic benefits in type 2 diabetes, although the underlying mechanisms remain unclear. The possibility of altering metabolism through RNA-based therapies is also intriguing. This conference will bring together a diverse array of scientists from academia and industry, thereby facilitating knowledge exchange and interactions, leading to elucidation of better treatments. Joint sessions with the simultaneous conference on “Obesity and Adipose Tissue Biology” will create opportunities for synergies. Specifically, the conference will examine recent advances in understanding of brown/beige adipose tissue function; endocrine, paracrine and nutrient signaling; molecular mechanisms of metabolic signaling; emerging topics, including long noncoding RNA and the influence of the gut microbiome; and new approaches to drug development for treating diabetes and obesity.

Global Health Travel Award Deadline: August 23 2016

Scholarship Deadline: September 22 2016

Discounted Abstract Deadline: September 22 2016

Abstract Deadline: October 25 2016

Discounted Registration Deadline: November 22 2016

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK104616-02
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK104616-03
Funding for this conference was made possible (in part) by 5R13DK104616-03 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, January 22 \| 4:00PM - 8:00PM Arrival and Registration Room: Longs Peak Foyer
Sunday, January 22 \| 6:00PM - 8:00PM Welcome Mixer Room: Longs Peak Foyer No registration fees are used to fund alcohol served at this function.
Monday, January 23 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Monday, January 23 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Columbine Ballroom Speaker 1 of 5 * Jiandie Lin, University of Michigan Medical School, USA
Monday, January 23 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Columbine Ballroom Speaker 2 of 5 * Marc L. Reitman, NIDDK, National Institutes of Health, USA
Monday, January 23 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Columbine Ballroom Speaker 3 of 5 Philipp E. Scherer, University of Texas Southwestern Medical Center, USA Journal of Lipid Research Lectureship: Adipose Origin and Expansion
Monday, January 23 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Columbine Ballroom Speaker 4 of 5 Richard D. DiMarchi, Indiana University and Novo Nordisk, USA Chemical Biotechnology Applied to Metabolic Diseases
Monday, January 23 \| 8:00AM - 9:30AM Welcome and Keynote Session (Joint) Room: Columbine Ballroom Coffee Break
Monday, January 23 \| 9:50AM - 12:15PM Brown/Beige Fat Activation and Function (Joint) Room: Columbine Ballroom Speaker 1 of 5 * Antonio J. Vidal-Puig, University of Cambridge, UK
Monday, January 23 \| 9:50AM - 12:15PM Brown/Beige Fat Activation and Function (Joint) Room: Columbine Ballroom Speaker 2 of 5 Jan Nedergaard, Stockholm University, Sweden Brown Adipose Physiology
Monday, January 23 \| 9:50AM - 12:15PM Brown/Beige Fat Activation and Function (Joint) Room: Columbine Ballroom Speaker 3 of 5 Aaron M. Cypess, NIDDK, National Institutes of Health, USA Activation of Brown Adipose Tissue in Humans
Monday, January 23 \| 9:50AM - 12:15PM Brown/Beige Fat Activation and Function (Joint) Room: Columbine Ballroom Speaker 4 of 5 Ajay Chawla, Merck Research Labs, USA Innate Immune Licensing of Thermogenesis
Monday, January 23 \| 9:50AM - 12:15PM Brown/Beige Fat Activation and Function (Joint) Room: Columbine Ballroom Speaker 5 of 5 Patrick Seale, University of Pennsylvania, USA Regulators of Brown and Beige Fat Activity
Monday, January 23 \| 12:15PM - 2:30PM On Own for Lunch
Monday, January 23 \| 12:15PM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Monday, January 23 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Monday, January 23 \| 2:30PM - 4:30PM Workshop 1: Drug Discovery/Development in Obesity (Joint) Room: Grays/Long Peak Speaker 1 of 9 * Bei Shan, Lilly China Research and Development Center, China
Monday, January 23 \| 2:30PM - 4:30PM Workshop 1: Drug Discovery/Development in Obesity (Joint) Room: Grays/Long Peak Speaker 2 of 9 Michelle L. Boland, Medimmune, USA MEDI0382, a Dual GLP-1/Glucagon Receptor Agonist, is More Effective on Alleviating Non-Alcoholic Steatohepatitis (NASH) Compared to Liraglutide in a Mouse Model of NASH
Monday, January 23 \| 2:30PM - 4:30PM Workshop 1: Drug Discovery/Development in Obesity (Joint) Room: Grays/Long Peak Speaker 3 of 9 Andrea Galmozzi, The Scripps Research Institute, USA Chemoproteomics-driven Discovery of PGRMC2 as a New Regulator of Adipocyte Physiology with Therapeutic Potential in Obesity-Linked Diabetes
Monday, January 23 \| 2:30PM - 4:30PM Workshop 1: Drug Discovery/Development in Obesity (Joint) Room: Grays/Long Peak Speaker 4 of 9 Hua V. Lin, BioFront Therapeutics, China GPR142 Agonists Improve Beta Cell Proliferation and Survival
Monday, January 23 \| 2:30PM - 4:30PM Workshop 1: Drug Discovery/Development in Obesity (Joint) Room: Grays/Long Peak Speaker 5 of 9 Kfir Sharabi, Dana-Farber Cancer Institute, USA Small Molecule Screen Identifies Selective PGC-1alpha Gluconeogenic Inhibitors that Ameliorate Diabetic Symptoms
Monday, January 23 \| 2:30PM - 4:30PM Workshop 1: Drug Discovery/Development in Obesity (Joint) Room: Grays/Long Peak Speaker 6 of 9 Cholsoon Jang, Princeton University, USA A Metabolite of Branched Chain Amino Acids Drives Vascular Fatty Acid Transport and Insulin Resistance
Monday, January 23 \| 2:30PM - 4:30PM Workshop 1: Drug Discovery/Development in Obesity (Joint) Room: Grays/Long Peak Speaker 7 of 9 Zheng Sun, Baylor College of Medicine, USA Dissociation of Muscle Glucose Utilization from Exercise Endurance by Circadian Epigenomic Regulator HDAC3
Monday, January 23 \| 2:30PM - 4:30PM Workshop 1: Drug Discovery/Development in Obesity (Joint) Room: Grays/Long Peak Speaker 8 of 9 Jonathan Z. Long, Dana-Farber Cancer Institute, USA The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria
Monday, January 23 \| 2:30PM - 4:30PM Workshop 1: Drug Discovery/Development in Obesity (Joint) Room: Grays/Long Peak Speaker 9 of 9 Nicolai Jacob Wewer Albrechtsen, University of Copenhagen, Denmark An Insulinotropic Glucagon Variant Identified in Man
Monday, January 23 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, January 23 \| 5:00PM - 7:00PM Exercise and Type 2 Diabetes Room: Quandary Peak Speaker 1 of 5 * Clay F. Semenkovich, Washington University School of Medicine, USA
Monday, January 23 \| 5:00PM - 7:00PM Exercise and Type 2 Diabetes Room: Quandary Peak Speaker 2 of 5 Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA Exercise Regulation of Adipose Tissue
Monday, January 23 \| 5:00PM - 7:00PM Exercise and Type 2 Diabetes Room: Quandary Peak Speaker 3 of 5 Juleen R. Zierath, Karolinska Institutet, Sweden The Role of Diet and Exercise in the Epigenetic Landscape of Type 2 Diabetes
Monday, January 23 \| 5:00PM - 7:00PM Exercise and Type 2 Diabetes Room: Quandary Peak Speaker 4 of 5 Christoph Handschin, University of Basel, Switzerland Regulation of Physiological and Dietary Ketone Body Homeostasis and Diabetic Hyperketosis by Muscle PGC-1alpha and Exercise
Monday, January 23 \| 5:00PM - 7:00PM Exercise and Type 2 Diabetes Room: Quandary Peak Speaker 5 of 5 Xingxing Kong, Beth Israel Deaconess Medical Center, Harvard Medical School, USA Short Talk: Brown Fat Dysfunction Induces Skeletal Muscle Myopathy via an IRF4-Myostatin-Mediated Pathway
Monday, January 23 \| 5:00PM - 7:15PM Adipose Tissue Development This session is from Obesity Room: Grays/Longs Peak Speaker 1 of 6 * Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Monday, January 23 \| 5:00PM - 7:15PM Adipose Tissue Development This session is from Obesity Room: Grays/Longs Peak Speaker 2 of 6 Evan D. Rosen, Harvard University, USA Insights from the Epigenomic Analysis of Human and Murine Adipose Tissue
Monday, January 23 \| 5:00PM - 7:15PM Adipose Tissue Development This session is from Obesity Room: Grays/Longs Peak Speaker 3 of 6 Christian Wolfrum, ETH Zürich, Switzerland Adipose Tissue Stem Cells
Monday, January 23 \| 5:00PM - 7:15PM Adipose Tissue Development This session is from Obesity Room: Grays/Longs Peak Speaker 4 of 6 Silvia Corvera, University of Massachusetts Medical School, USA Origin and Function of Human Brite/Beige Adipocytes
Monday, January 23 \| 5:00PM - 7:15PM Adipose Tissue Development This session is from Obesity Room: Grays/Longs Peak Speaker 5 of 6 Zachary Sebo, Yale University, USA Short Talk: A Sexually Dimorphic Mesodermal Fate Map for Adipose Tissue
Monday, January 23 \| 5:00PM - 7:15PM Adipose Tissue Development This session is from Obesity Room: Grays/Longs Peak Speaker 6 of 6 Rana K. Gupta, University of Texas Southwestern Medical Center, USA Short Talk: Visceral Adipocyte Differentiation from Mural Adipose Precursors Protects Against Pathological Adipose Tissue Expansion and Insulin Resistance in Obesity
Monday, January 23 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Monday, January 23 \| 7:30PM - 10:00PM Poster Session 1 Room: Colorado Rockies Ballroom
Tuesday, January 24 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Tuesday, January 24 \| 8:00AM - 11:15AM Interorgan Metabolic Crosstalk via Secreted Factors (Joint) Room: Columbine Ballroom Speaker 1 of 8 * Christoph Handschin, University of Basel, Switzerland
Tuesday, January 24 \| 8:00AM - 11:15AM Interorgan Metabolic Crosstalk via Secreted Factors (Joint) Room: Columbine Ballroom Speaker 2 of 8 Takashi Kadowaki, University of Tokyo, Japan Adiponectin Receptors: A Major Treatment Target in Type 2 Diabetes and Obesity-Linked Diseases
Tuesday, January 24 \| 8:00AM - 11:15AM Interorgan Metabolic Crosstalk via Secreted Factors (Joint) Room: Columbine Ballroom Speaker 3 of 8 Jiandie Lin, University of Michigan Medical School, USA The Brown Fat Secretome: Metabolic Functions Beyond Thermogenesis
Tuesday, January 24 \| 8:00AM - 11:15AM Interorgan Metabolic Crosstalk via Secreted Factors (Joint) Room: Columbine Ballroom Coffee Break
Tuesday, January 24 \| 8:00AM - 11:15AM Interorgan Metabolic Crosstalk via Secreted Factors (Joint) Room: Columbine Ballroom Speaker 5 of 8 David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA The Diverse Metabolic Actions of FGF21
Tuesday, January 24 \| 8:00AM - 11:15AM Interorgan Metabolic Crosstalk via Secreted Factors (Joint) Room: Columbine Ballroom Speaker 6 of 8 Yonghao Yu, University of Texas Southwestern Medical Center, USA Large Scale Proteomic Analysis Identifies IGFBP5 as a Secreted mTORC1 Target that Mediates mTORC1-Dependent Feedback Inhibition of IGF-1 Signaling
Tuesday, January 24 \| 8:00AM - 11:15AM Interorgan Metabolic Crosstalk via Secreted Factors (Joint) Room: Columbine Ballroom Speaker 7 of 8 Russell A. Miller, Pfizer Inc., USA Short Talk: Glucagon Stimulates Hepatic Glutamine Utilization by Increasing Metabolic Flux through GLS2
Tuesday, January 24 \| 8:00AM - 11:15AM Interorgan Metabolic Crosstalk via Secreted Factors (Joint) Room: Columbine Ballroom Speaker 8 of 8 Lucas BonDurant, Alnylam Pharmaceuticals, USA Short Talk: FGF21 Signals Directly to Adipose Tissues to Acutely Enhance Insulin Sensitivity
Tuesday, January 24 \| 11:15AM - 5:00PM On Own for Lunch
Tuesday, January 24 \| 11:15AM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Tuesday, January 24 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Tuesday, January 24 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, January 24 \| 5:00PM - 7:00PM Long Noncoding and MicroRNAs and Metabolism Room: Quandary Peak Speaker 1 of 5 * Jiandie Lin, University of Michigan Medical School, USA
Tuesday, January 24 \| 5:00PM - 7:00PM Long Noncoding and MicroRNAs and Metabolism Room: Quandary Peak Speaker 2 of 5 Lori Sussel, University of Colorado Anschutz Medical Campus, USA Non-Coding Gene Regulation of the Pancreatic Islet
Tuesday, January 24 \| 5:00PM - 7:00PM Long Noncoding and MicroRNAs and Metabolism Room: Quandary Peak Speaker 3 of 5 Lei Sun, Duke-NUS Graduate Medical School Singapore, Singapore Regulatory Role of Long Noncoding RNAs in Adipose
Tuesday, January 24 \| 5:00PM - 7:00PM Long Noncoding and MicroRNAs and Metabolism Room: Quandary Peak Speaker 4 of 5 Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA A Role for MicroRNAs in Diabetes and Its Complications
Tuesday, January 24 \| 5:00PM - 7:00PM Long Noncoding and MicroRNAs and Metabolism Room: Quandary Peak Speaker 5 of 5 Congcong He, Northwestern University, USA Short Talk: Differential Roles of Autophagy in Insulin Production and Sensitivity
Tuesday, January 24 \| 5:00PM - 7:15PM Adipose Inflammation; Adipokines This session is from Obesity Room: Grays/Longs Peak Speaker 1 of 6 * Ajay Chawla, Merck Research Labs, USA
Tuesday, January 24 \| 5:00PM - 7:15PM Adipose Inflammation; Adipokines This session is from Obesity Room: Grays/Longs Peak Speaker 2 of 6 Ruth E. Gimeno, Eli Lilly and Company, USA Pharmacological Approaches to Adipose Tissue Function
Tuesday, January 24 \| 5:00PM - 7:15PM Adipose Inflammation; Adipokines This session is from Obesity Room: Grays/Longs Peak Speaker 3 of 6 Anthony W. Ferrante, Columbia University, USA Induction of Adipose Tissue Inflammation
Tuesday, January 24 \| 5:00PM - 7:15PM Adipose Inflammation; Adipokines This session is from Obesity Room: Grays/Longs Peak Speaker 4 of 6 Alyssa H. Hasty, Vanderbilt University, USA Macrophages as Adipose Tissue 'Ferrostats'
Tuesday, January 24 \| 5:00PM - 7:15PM Adipose Inflammation; Adipokines This session is from Obesity Room: Grays/Longs Peak Speaker 5 of 6 Prashant Rajbhandari, Icahn School of Medicine at Mount Sinai, USA Short Talk: Interleukin-10 Signaling Alters Chromatin Architecture in Adipose to Regulate Thermogenesis and Energy Expenditure
Tuesday, January 24 \| 5:00PM - 7:15PM Adipose Inflammation; Adipokines This session is from Obesity Room: Grays/Longs Peak Speaker 6 of 6 Min Jeong Choi, Chungnam National University, South Korea Short Talk: Secretory Factors Induced by Adipocyte Mitochondrial OxPhos Dysfunction Modulate Systemic Metabolism by Influencing the Adipose Immune Environment
Tuesday, January 24 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Tuesday, January 24 \| 7:30PM - 10:00PM Poster Session 2 Room: Colorado Rockies Ballroom
Wednesday, January 25 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Wednesday, January 25 \| 8:00AM - 11:15AM Gut Microbiome and Bariatric Surgery (Joint) Room: Columbine Ballroom Speaker 1 of 7 Patrice D. Cani, Université Catholique de Louvain, Belgium Specific Gut Microbiota and Intestinal Sensors: Focus on Novel Mechanisms Affecting Glucose and Energy Metabolism
Wednesday, January 25 \| 8:00AM - 11:15AM Gut Microbiome and Bariatric Surgery (Joint) Room: Columbine Ballroom Speaker 2 of 7 * Randy J. Seeley, University of Michigan, USA Gut Endocrine Signaling in Bariatric Surgery
Wednesday, January 25 \| 8:00AM - 11:15AM Gut Microbiome and Bariatric Surgery (Joint) Room: Columbine Ballroom Coffee Break
Wednesday, January 25 \| 8:00AM - 11:15AM Gut Microbiome and Bariatric Surgery (Joint) Room: Columbine Ballroom Speaker 4 of 7 Helen Raybould, University of California, Davis, USA The Microbiota-Gut-Brain Axis in the Control of Food Intake and Body Weight
Wednesday, January 25 \| 8:00AM - 11:15AM Gut Microbiome and Bariatric Surgery (Joint) Room: Columbine Ballroom Speaker 5 of 7 Fredrik Bäckhed, University of Gothenburg, Sweden Does Altered Gut Microbiome after Bariatric Surgery Contribute to Improved Metabolism?
Wednesday, January 25 \| 8:00AM - 11:15AM Gut Microbiome and Bariatric Surgery (Joint) Room: Columbine Ballroom Speaker 6 of 7 Jantje M. Gerdes, Helmholtz Zentrum München, Germany Short Talk: EphA/ephrin Signaling in Pancreatic Islets is Regulated by Primary Cilia
Wednesday, January 25 \| 8:00AM - 11:15AM Gut Microbiome and Bariatric Surgery (Joint) Room: Columbine Ballroom Speaker 7 of 7 Chieh Jason Chou, Nestlé Institute of Health Sciences SA, Switzerland Short Talk: The Effect of Diets on the Metabolic Benefits Associated with Post Bariatric Surgery Microbiota
Wednesday, January 25 \| 11:15AM - 5:00PM On Own for Lunch
Wednesday, January 25 \| 11:15AM - 1:00PM Poster Setup Room: Colorado Rockies Ballroom
Wednesday, January 25 \| 1:00PM - 10:00PM Poster Viewing Room: Colorado Rockies Ballroom
Wednesday, January 25 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, January 25 \| 5:00PM - 7:00PM Substrate Flux and Metabolic Signaling Room: Quandary Peak Speaker 1 of 5 * Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Wednesday, January 25 \| 5:00PM - 7:00PM Substrate Flux and Metabolic Signaling Room: Quandary Peak Speaker 2 of 5 Clay F. Semenkovich, Washington University School of Medicine, USA Lipid-Mediated Metabolic Signaling
Wednesday, January 25 \| 5:00PM - 7:00PM Substrate Flux and Metabolic Signaling Room: Quandary Peak Speaker 3 of 5 Gerald I. Shulman, Yale University School of Medicine, USA Role of Hepatic Acetyl CoA in the Regulation of Hepatic Gluconeogenesis in Normal and Diabetic States
Wednesday, January 25 \| 5:00PM - 7:00PM Substrate Flux and Metabolic Signaling Room: Quandary Peak Speaker 4 of 5 Christopher B. Newgard, Duke University Medical Center, USA Metabolic Flux and Homeostais
Wednesday, January 25 \| 5:00PM - 7:00PM Substrate Flux and Metabolic Signaling Room: Quandary Peak Speaker 5 of 5 Hongyuan Yang, University of New South Wales, Australia Short Talk: Understanding Congenital Generalized Lipodystrophy
Wednesday, January 25 \| 5:00PM - 7:15PM Neural Control of Adipose/Adipose Function This session is from Obesity Room: Grays/Longs Peak Speaker 1 of 6 * Jan Nedergaard, Stockholm University, Sweden
Wednesday, January 25 \| 5:00PM - 7:15PM Neural Control of Adipose/Adipose Function This session is from Obesity Room: Grays/Longs Peak Speaker 2 of 6 Heike Münzberg, Pennington Biomedical Research Center, USA Central Circuits of Thermoregulatory Leptin Action
Wednesday, January 25 \| 5:00PM - 7:15PM Neural Control of Adipose/Adipose Function This session is from Obesity Room: Grays/Longs Peak Speaker 3 of 6 Rudolf Zechner, University of Graz, Austria Adipose Triglyceride Lipase
Wednesday, January 25 \| 5:00PM - 7:15PM Neural Control of Adipose/Adipose Function This session is from Obesity Room: Grays/Longs Peak Speaker 4 of 6 Joerg Heeren, University Medical Center Hamburg-Eppendorf, Germany Brown Fat and Lipid Metabolism
Wednesday, January 25 \| 5:00PM - 7:15PM Neural Control of Adipose/Adipose Function This session is from Obesity Room: Grays/Longs Peak Speaker 5 of 6 Peter K. Jackson, Stanford University, USA Short Talk: Linking Monogenic and Complex Obesity to Primary Cilia: The Cep19 Obesity Protein Regulates a Conserved GTPase Cycle Coupling Cargo to the IFT-B Complex for Ciliary Transport of the BBSome and GPCRs
Wednesday, January 25 \| 5:00PM - 7:15PM Neural Control of Adipose/Adipose Function This session is from Obesity Room: Grays/Longs Peak Speaker 6 of 6 Qi Wu, Baylor College of Medicine, USA Short Talk: Deciphering an AgRP-Dorsal Raphe Neural Circuit in Exclusive Control of Energy Expenditure
Wednesday, January 25 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Wednesday, January 25 \| 7:30PM - 10:00PM Poster Session 3 Room: Colorado Rockies Ballroom
Thursday, January 26 \| 7:00AM - 8:00AM Breakfast Room: Colorado Rockies Ballroom
Thursday, January 26 \| 8:00AM - 11:15AM Mechanisms of Nutrient Signaling Room: Quandary Peak Speaker 1 of 8 * Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA
Thursday, January 26 \| 8:00AM - 11:15AM Mechanisms of Nutrient Signaling Room: Quandary Peak Speaker 2 of 8 Antonio J. Vidal-Puig, University of Cambridge, UK Adipose Tissue Expandability, Lipotoxicity and the Metabolic Syndrome
Thursday, January 26 \| 8:00AM - 11:15AM Mechanisms of Nutrient Signaling Room: Quandary Peak Speaker 3 of 8 C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA Metabolic Signaling in Physiology and Disease
Thursday, January 26 \| 8:00AM - 11:15AM Mechanisms of Nutrient Signaling Room: Quandary Peak Coffee Break
Thursday, January 26 \| 8:00AM - 11:15AM Mechanisms of Nutrient Signaling Room: Quandary Peak Speaker 5 of 8 Hei Sook Sul, University of California, Berkeley, USA Regulation of Fat Metabolism
Thursday, January 26 \| 8:00AM - 11:15AM Mechanisms of Nutrient Signaling Room: Quandary Peak Speaker 6 of 8 Jun Wu, University of Michigan, USA Beige-Fat-Specific Regulation in Mouse and Human
Thursday, January 26 \| 8:00AM - 11:15AM Mechanisms of Nutrient Signaling Room: Quandary Peak Speaker 7 of 8 Feng Liu, University of Texas Health Science Center, USA Short Talk: DsbA-L Suppresses Inflammation and Promotes Beiging and Thermogenesis by Improving Mitochondrial Function
Thursday, January 26 \| 8:00AM - 11:15AM Mechanisms of Nutrient Signaling Room: Quandary Peak Speaker 8 of 8 Adilson L. Guilherme, University of Massachusetts Medical School, USA Short Talk: Suppression of Adipocyte Fatty Acid Synthase in Adult Mice Enhances Adipose Sympathetic Activity and Browning to Improve Glucose Homeostasis in Obese Mice
Thursday, January 26 \| 8:00AM - 11:00AM Genetics and Systems Biology This session is from Obesity Room: Grays/Longs Peak Speaker 1 of 7 * Evan D. Rosen, Harvard University, USA
Thursday, January 26 \| 8:00AM - 11:00AM Genetics and Systems Biology This session is from Obesity Room: Grays/Longs Peak Speaker 2 of 7 Umut Ozcan, Harvard Medical School, USA Role of Endoplasmic Reticulum Stress in Development of Obesity and Type 2 Diabetes
Thursday, January 26 \| 8:00AM - 11:00AM Genetics and Systems Biology This session is from Obesity Room: Grays/Longs Peak Speaker 3 of 7 Ruth J.F. Loos, Mount Sinai School of Medicine, USA The Genetics of Obesity - Going Beyond Common Variation and Common Phenotypes
Thursday, January 26 \| 8:00AM - 11:00AM Genetics and Systems Biology This session is from Obesity Room: Grays/Longs Peak Coffee Break
Thursday, January 26 \| 8:00AM - 11:00AM Genetics and Systems Biology This session is from Obesity Room: Grays/Longs Peak Speaker 5 of 7 Jose C. Florez, Massachusetts General Hospital, USA Pharmacogenetics of Type 2 Diabetes
Thursday, January 26 \| 8:00AM - 11:00AM Genetics and Systems Biology This session is from Obesity Room: Grays/Longs Peak Speaker 6 of 7 Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA Transcriptional Regulation of Metabolism
Thursday, January 26 \| 8:00AM - 11:00AM Genetics and Systems Biology This session is from Obesity Room: Grays/Longs Peak Speaker 7 of 7 Yi Chen, Dana-Farber Cancer Institute, USA Short Talk: Potassium Current Through KCNK3 Regulates Brown Adipose Thermogenesis and Obesity
Thursday, January 26 \| 11:15AM - 5:00PM On Own for Lunch
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Metabolic Regulation in Physiology and Disease Room: Quandary Peak Speaker 1 of 9 * Dave Bridges, University of Michigan, USA
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Metabolic Regulation in Physiology and Disease Room: Quandary Peak Speaker 2 of 9 Constanza J. Cortes Rodriguez, University of Alabama at Birmingham, USA Skeletal Muscle Control of Systemic Metabolism: A Role for Transcription Factor E-B (TFEB) Signaling
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Metabolic Regulation in Physiology and Disease Room: Quandary Peak Speaker 3 of 9 Zhuoxian Meng, University of Michigan, USA Glucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Metabolic Regulation in Physiology and Disease Room: Quandary Peak Speaker 4 of 9 Tiemin Liu, University of Texas Southwestern Medical Center, USA 5-HT2C Receptors in Brainstem Neurons Regulate Glucose Homeostasis
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Metabolic Regulation in Physiology and Disease Room: Quandary Peak Speaker 5 of 9 Fajun Yang, Albert Einstein College of Medicine, USA Cyclin C Regulates Brown Fat Development and Function
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Metabolic Regulation in Physiology and Disease Room: Quandary Peak Speaker 6 of 9 Yanhui Zhang, University of Iowa, USA SWELL1 is a Regulator of Adipocyte Size, Insulin Signaling and Glucose Homeostasis
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Metabolic Regulation in Physiology and Disease Room: Quandary Peak Speaker 7 of 9 Andrew C. Shin, Texas Tech University, USA Insulin Receptor Signaling in POMC, but not AgRP, Neurons Controls Adipose Tissue Insulin Action
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Metabolic Regulation in Physiology and Disease Room: Quandary Peak Speaker 8 of 9 Jakob G. Knudsen, University of Oxford, UK Glucagon Secretion is Dependent on Alpha-Cell Fatty Acid Oxidation
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Metabolic Regulation in Physiology and Disease Room: Quandary Peak Speaker 9 of 9 Meilian Liu, University of New Mexico Health Sciences Center, USA Adipose mTORC1 Suppresses Beige Fat Development via Autophagy-Dependent Mechanisms
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Adipose Thermogenesis and a Little Bit More This session is from Obesity Room: Grays/Longs Peak Speaker 1 of 10 * Barbara Cannon, Stockholm University, Sweden
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Adipose Thermogenesis and a Little Bit More This session is from Obesity Room: Grays/Longs Peak Speaker 2 of 10 * Matthias Blüher, University of Leipzig, Germany
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Adipose Thermogenesis and a Little Bit More This session is from Obesity Room: Grays/Longs Peak Speaker 3 of 10 Erin L. Brown, Johns Hopkins Medical Institute, USA Regulation of Adipose Tissue Thermogenic Capacity by Estrogen-Related Receptors
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Adipose Thermogenesis and a Little Bit More This session is from Obesity Room: Grays/Longs Peak Speaker 4 of 10 Shunbun Kita, Graduate School of Medicine, Osaka University, Japan Adiponectin/T-Cadherin System Regulates Exosome Biogenesis and Systemic Plasma Exosome Level
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Adipose Thermogenesis and a Little Bit More This session is from Obesity Room: Grays/Longs Peak Speaker 5 of 10 Pegah Poursharifi, University of Montreal-CRCHUM, Canada ABHD6 Negatively Regulates Thermogenic Adaptive Responses under Cold Stress
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Adipose Thermogenesis and a Little Bit More This session is from Obesity Room: Grays/Longs Peak Speaker 6 of 10 Pingwen Xu, Baylor College of Medicine, USA Ventral Medial Hypothalamus ERalpha Neurocircuits in the Regulation of Thermogenesis and Physical Activity
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Adipose Thermogenesis and a Little Bit More This session is from Obesity Room: Grays/Longs Peak Speaker 7 of 10 Ludger Scheja, University Medical Center Hamburg-Eppendorf, Germany Carbohydrate Response Element Binding Protein Regulates de novo Lipogenesis in Brown Adipose Tissue and Adaptive thermogenesis
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Adipose Thermogenesis and a Little Bit More This session is from Obesity Room: Grays/Longs Peak Speaker 8 of 10 Roland H. Stimson, University of Edinburgh, UK Direct Measurement of in vivo Substrate Utilisation by Human Brown Adipose Tissue
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Adipose Thermogenesis and a Little Bit More This session is from Obesity Room: Grays/Longs Peak Speaker 9 of 10 Claudio J. Villanueva, University of California, Los Angeles, USA Global Analysis of Plasma Lipids Identifies Liver-Derived Acyl-Carnitines as a Fuel Source for Brown Fat Thermogenesis
Thursday, January 26 \| 2:30PM - 4:30PM Workshop 2: Adipose Thermogenesis and a Little Bit More This session is from Obesity Room: Grays/Longs Peak Speaker 10 of 10 Mary N. Teruel, Stanford University, USA Transcription Factor Dynamics Define a Circadian Code for Fat Cell Differentiation
Thursday, January 26 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, January 26 \| 5:00PM - 6:45PM Emerging Topics in Diabetes Room: Quandary Peak Speaker 1 of 4 * Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
Thursday, January 26 \| 5:00PM - 6:45PM Emerging Topics in Diabetes Room: Quandary Peak Speaker 2 of 4 Stephan Kissler, Joslin Diabetes Center, USA Immune Dysregulation Underlying Type 1 Diabetes
Thursday, January 26 \| 5:00PM - 6:45PM Emerging Topics in Diabetes Room: Quandary Peak Speaker 3 of 4 Ralph A. DeFronzo, University of Texas Health Sciences Center at San Antonio, USA The Kidney and Glucose Homeostasis: Implications for Therapy
Thursday, January 26 \| 5:00PM - 6:45PM Emerging Topics in Diabetes Room: Quandary Peak Speaker 4 of 4 Jayne S. Danska, Hospital for Sick Children Research Institute, Canada Diabetes Trialog: Genes, Sex and the Microbiome
Thursday, January 26 \| 5:00PM - 7:15PM Treatment of Obesity This session is from Obesity Room: Grays/Longs Peak Speaker 1 of 6 * Ruth E. Gimeno, Eli Lilly and Company, USA
Thursday, January 26 \| 5:00PM - 7:15PM Treatment of Obesity This session is from Obesity Room: Grays/Longs Peak Speaker 2 of 6 Steven R. Smith, AdventHealth, USA Clinical Obesity Treatment - Quantitative Bioenergetics
Thursday, January 26 \| 5:00PM - 7:15PM Treatment of Obesity This session is from Obesity Room: Grays/Longs Peak Speaker 3 of 6 Matthias Blüher, University of Leipzig, Germany New Developments in Treatment of Obesity
Thursday, January 26 \| 5:00PM - 7:15PM Treatment of Obesity This session is from Obesity Room: Grays/Longs Peak Speaker 4 of 6 Marc L. Reitman, NIDDK, National Institutes of Health, USA Role of Body and Environmental Temperature in Energy Homeostasis and Drug Development
Thursday, January 26 \| 5:00PM - 7:15PM Treatment of Obesity This session is from Obesity Room: Grays/Longs Peak Speaker 5 of 6 Denis P. Blondin, University of Sherbrooke, Canada Short Talk: The Use of a Beta3-Adrenergic Receptor Agonist in Humans Stimulates BAT Glucose Disposal, but not Thermogenesis
Thursday, January 26 \| 5:00PM - 7:15PM Treatment of Obesity This session is from Obesity Room: Grays/Longs Peak Speaker 6 of 6 Minna Lahesmaa, Turku PET Centre, Finland Short Talk: Cannabinoid CB1 Receptors in Human Brown Adipose Tissue during Cold Exposure
Thursday, January 26 \| 6:45PM - 7:00PM Meeting Wrap-Up: Outcomes and Future Directions Room: Quandary Peak Speaker 1 of 1 * Clay F. Semenkovich, Washington University School of Medicine, USA
Thursday, January 26 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Colorado Rockies Ballroom No registration fees are used to fund alcohol served at this function.
Thursday, January 26 \| 7:15PM - 7:30PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) This session is from Obesity Room: Grays/Longs Peak
Thursday, January 26 \| 8:00PM - 11:00PM Entertainment Room: Colorado Rockies Ballroom Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources. Novo Nordisk A/S funding is not being used for this function.
Thursday, January 26 \| 8:00PM - 11:00PM Cash Bar Room: Colorado Rockies Ballroom
Friday, January 27 \| 10:25AM - 10:25AM Departure *Session Chair.