Web Desc
Engineered Cells and Tissues as Platforms for Discovery and Therapy
Organizer(s): Laura E. Niklason, Milica Radisic and Nenad Bursac
Date: March 09 - 12, 2017
Location: Fairmont Copley Plaza, Boston, MA, USA
Sponsored by Editas Medicine, Inc., Juno Therapeutics, Merck & Co., Inc. and Thermo Fisher Scientific Inc.
Summary of Meeting:
Tissue engineering, cell therapies and regenerative medicine have witnessed accelerated progress over the past decade. Fueled by fundamental discoveries in iPS, progenitor, and developmental cell biology, cells are now used as building blocks to create model systems, as testing platforms for drug interventions and as active therapeutics. High-throughput production of various types of “microtissues” or “organoids” is making increasing contributions to our understanding of human development, disease and repair. This Keystone Symposia meeting will highlight these rapidly emerging cell-based tools for fundamental and applied discovery. Culture systems ranging from simple cell cluster organoids, to highly advanced cell-electronic composites, will be discussed. In addition, the encouraging progress that is being made in cell-based therapies across a range of organs and diseases will be featured. The goal of this meeting is to provide a state-of-the-art review of both pluripotent and differentiated cells as tools for discovery and therapy. A broad range of cell types and therapeutic areas will be included.
Scholarship Deadline: November 9 2016
Discounted Abstract Deadline: November 9 2016
Abstract Deadline: December 13 2016
Discounted Registration Deadline: January 13 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Editas Medicine, Inc.Juno TherapeuticsMerck & Co., Inc.Thermo Fisher Scientific Inc.
We gratefully acknowledge additional support for this conference from:
InSphero Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

AbbVie Inc.

ViaCyte, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
American Association for the Advancement of Science (AAAS)
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, March 09 | 4:00PM - 8:00PM
Arrival and Registration
Room: Lobby


Thursday, March 09 | 6:00PM - 8:00PM
Welcome Mixer
Room: Venetian Room
No registration fees are used to fund alcohol served at this function.

Friday, March 10 | 7:30AM - 8:30AM
Breakfast
Room: Venetian Room


Friday, March 10 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Oval Room

Speaker 2 of 2
Danilo A. Tagle, NCATS, National Institutes of Health, USA
Catalyzing Translational Innovation

Friday, March 10 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Oval Room

Speaker 1 of 2
* Laura E. Niklason, Yale University, USA

Friday, March 10 | 9:30AM - 12:15PM
Biologically-Based Microsystems
Room: Oval Room

Speaker 1 of 6
* Jordan S. Miller, Rice University, USA

Friday, March 10 | 9:30AM - 12:15PM
Biologically-Based Microsystems
Room: Oval Room

Speaker 2 of 6
Jeffrey Beekman, University Medical Center Utrecht, Netherlands
Epithelial Organoids as Tools for Discovery in Cystic Fibrosis

Friday, March 10 | 9:30AM - 12:15PM
Biologically-Based Microsystems
Room: Oval Room


Coffee Break

Friday, March 10 | 9:30AM - 12:15PM
Biologically-Based Microsystems
Room: Oval Room

Speaker 4 of 6
Takanori Takebe, Cincinnati Children's Hospital Medical Center, Japan
De novo Generation of Diverse Organ Buds from Stem Cells

Friday, March 10 | 9:30AM - 12:15PM
Biologically-Based Microsystems
Room: Oval Room

Speaker 5 of 6
Todd C. McDevitt, Gladstone Institutes, USA
Complex Cellular Models of Embryonic Development

Friday, March 10 | 9:30AM - 12:15PM
Biologically-Based Microsystems
Room: Oval Room

Speaker 6 of 6
Eduardo Marban, Cedars-Sinai Medical Center, USA
Self-Assembling Cardiac Microtissues and their Progeny in Clinical Therapeutics

Friday, March 10 | 12:15PM - 5:00PM
On Own for Lunch


Friday, March 10 | 12:15PM - 1:00PM
Poster Setup
Room: Copley and Singleton Rooms


Friday, March 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Copley and Singleton Rooms


Friday, March 10 | 2:30PM - 4:30PM
Workshop 1: Human iPS Cells in Disease Modeling
Room: Oval Room

Speaker 1 of 7
* Todd C. McDevitt, Gladstone Institutes, USA

Friday, March 10 | 2:30PM - 4:30PM
Workshop 1: Human iPS Cells in Disease Modeling
Room: Oval Room

Speaker 2 of 7
Olga Kashpur, Tufts University, USA
Reprogramming of Diabetic Foot Ulcer Fibroblasts to iPSCs Reveals an
Altered Wound Healing Potential


Friday, March 10 | 2:30PM - 4:30PM
Workshop 1: Human iPS Cells in Disease Modeling
Room: Oval Room

Speaker 3 of 7
Adriana Blazeski, Johns Hopkins University, USA
Engineered Heart Slices Represent Syncytial Model of Arrhythmogenic Cardiomyopathy

Friday, March 10 | 2:30PM - 4:30PM
Workshop 1: Human iPS Cells in Disease Modeling
Room: Oval Room

Speaker 4 of 7
Miguel Angel Hermida, Heriot Watt University, UK
3D Printing of Multilineage Human Glioblastoma Models

Friday, March 10 | 2:30PM - 4:30PM
Workshop 1: Human iPS Cells in Disease Modeling
Room: Oval Room

Speaker 5 of 7
Alex Ng, Harvard Medical School, USA
Transcription Factor-Wide Engineering of Human Cell Types from Pluripotent Stem Cells

Friday, March 10 | 2:30PM - 4:30PM
Workshop 1: Human iPS Cells in Disease Modeling
Room: Oval Room

Speaker 6 of 7
Jeffrey D. Serrill, City of Hope, USA
Using NGN3 Fusion Protein Constructs to Elucidate Optimal Cytoarchitecture in hPSC-Derived Pseudoislets

Friday, March 10 | 2:30PM - 4:30PM
Workshop 1: Human iPS Cells in Disease Modeling
Room: Oval Room

Speaker 7 of 7
Kacey Ronaldson, Columbia University, USA
Adult-Like Cardiac Tissue Bio-Engineered From Human Ips Derived Cells Enables Predictive Modeling of Toxicity and Disease

Friday, March 10 | 4:30PM - 5:00PM
Coffee Available
Room: Venetian Room


Friday, March 10 | 5:00PM - 7:00PM
Engineered Organoids for Biological Discovery
Room: Oval Room

Speaker 1 of 5
* Gary A. Gintant, AbbVie, Inc., USA

Friday, March 10 | 5:00PM - 7:00PM
Engineered Organoids for Biological Discovery
Room: Oval Room

Speaker 2 of 5
Anjelica L. Gonzalez, Yale University, USA
Interstitial and Microvascular Interfaces in Inflammatory and Fibrotic Disease

Friday, March 10 | 5:00PM - 7:00PM
Engineered Organoids for Biological Discovery
Room: Oval Room

Speaker 3 of 5
Nenad Bursac, Duke University, USA
Microtissues for Studies of Skeletal Muscle Physiology and Disease


Friday, March 10 | 5:00PM - 7:00PM
Engineered Organoids for Biological Discovery
Room: Oval Room

Speaker 4 of 5
Eva-Maria Dehne, TissUse GmbH and Technische Universitat Berlin, Germany
Microphysiological Systems – State of the Art and Future Perspectives

Friday, March 10 | 5:00PM - 7:00PM
Engineered Organoids for Biological Discovery
Room: Oval Room

Speaker 5 of 5
Abhishek Ananthanarayanan, Invitrocue Pte Ltd., Singapore
Short Talk: Hepatocyte Spheroid Cultures in Galactosylated Cellulosic Sponge for Drug DMPK and Efficacy Testing

Friday, March 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Venetian Room
No registration fees are used to fund alcohol served at this function.

Friday, March 10 | 7:30PM - 10:00PM
Poster Session 1
Room: Copley and Singleton Rooms


Saturday, March 11 | 7:30AM - 8:30AM
Breakfast
Room: Venetian Room


Saturday, March 11 | 8:30AM - 11:30AM
Cell-Based Platforms for Drug Screening
Room: Oval Room

Speaker 1 of 7
* Nenad Bursac, Duke University, USA

Saturday, March 11 | 8:30AM - 11:30AM
Cell-Based Platforms for Drug Screening
Room: Oval Room

Speaker 2 of 7
Gary A. Gintant, AbbVie, Inc., USA
Development of an in vitro Pro-Arrhythmia Assay

Saturday, March 11 | 8:30AM - 11:30AM
Cell-Based Platforms for Drug Screening
Room: Oval Room

Speaker 3 of 7
Sharon Presnell, Organovo, Inc., USA
Bioprinting of Liver Organoids

Saturday, March 11 | 8:30AM - 11:30AM
Cell-Based Platforms for Drug Screening
Room: Oval Room


Coffee Break

Saturday, March 11 | 8:30AM - 11:30AM
Cell-Based Platforms for Drug Screening
Room: Oval Room

Speaker 5 of 7
Milica Radisic, University of Toronto, Canada
Evaluation of Cardiotoxicity Using Biowires

Saturday, March 11 | 8:30AM - 11:30AM
Cell-Based Platforms for Drug Screening
Room: Oval Room

Speaker 6 of 7
Karl-Heinz Krause, University of Geneva Faculty of Medicine, Switzerland
Engineered Neural Tissues as Human Disease Models

Saturday, March 11 | 8:30AM - 11:30AM
Cell-Based Platforms for Drug Screening
Room: Oval Room

Speaker 7 of 7
Patrick Guye, InSphero AG, Switzerland
Short Talk: A Microfluidic Multi-Tissue Culturing Platform Based on 3D Microtissue Spheroids

Saturday, March 11 | 11:30AM - 5:00PM
On Own for Lunch


Saturday, March 11 | 11:30AM - 1:00PM
Poster Setup
Room: Copley and Singleton Rooms


Saturday, March 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Copley and Singleton Rooms


Saturday, March 11 | 2:30PM - 4:30PM
Workshop 2: Career Development
Room: Oval Room
The organizers will facilitate an interactive session on early career development in an effort to enhance the interactions between young and established investigators.
Speaker 1 of 3
* Laura E. Niklason, Yale University, USA

Saturday, March 11 | 2:30PM - 4:30PM
Workshop 2: Career Development
Room: Oval Room
The organizers will facilitate an interactive session on early career development in an effort to enhance the interactions between young and established investigators.
Speaker 2 of 3
* Milica Radisic, University of Toronto, Canada

Saturday, March 11 | 2:30PM - 4:30PM
Workshop 2: Career Development
Room: Oval Room
The organizers will facilitate an interactive session on early career development in an effort to enhance the interactions between young and established investigators.
Speaker 3 of 3
* Nenad Bursac, Duke University, USA

Saturday, March 11 | 4:30PM - 5:00PM
Coffee Available
Room: Venetian Room


Saturday, March 11 | 5:00PM - 7:00PM
Engineered Tissues in Cancer
Room: Oval Room

Speaker 1 of 5
* Milica Radisic, University of Toronto, Canada

Saturday, March 11 | 5:00PM - 7:00PM
Engineered Tissues in Cancer
Room: Oval Room

Speaker 2 of 5
Biju Parekkadan, Rutgers University, USA
Engineered Cancer-Stroma Microenvironments

Saturday, March 11 | 5:00PM - 7:00PM
Engineered Tissues in Cancer
Room: Oval Room

Speaker 3 of 5
Jordan S. Miller, Rice University, USA
Models of Lung Cancer Invasion and Metastasis

Saturday, March 11 | 5:00PM - 7:00PM
Engineered Tissues in Cancer
Room: Oval Room

Speaker 4 of 5
Alison P. McGuigan, University of Toronto, Canada
TRACER: An Engineered Tumor for Exploring Cellular Phenotype and Microenvironment in Hypoxic Gradients

Saturday, March 11 | 5:00PM - 7:00PM
Engineered Tissues in Cancer
Room: Oval Room

Speaker 5 of 5
Deena Mohamad Ameen Gendoo, University of Birmingham, UK
Short Talk: Comprehensive Assessment of the Genetic Landscape of Matched Primary, Xenograft, and Organoid Models for Pancreatic Cancer

Saturday, March 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Venetian Room
No registration fees are used to fund alcohol served at this function.

Saturday, March 11 | 7:30PM - 10:00PM
Poster Session 2
Room: Copley and Singleton Rooms


Sunday, March 12 | 7:30AM - 8:30AM
Breakfast
Room: Venetian Room


Sunday, March 12 | 8:30AM - 11:30AM
The Current Wave - Cells as Therapeutics
Room: Oval Room

Speaker 1 of 6
* Laura E. Niklason, Yale University, USA

Sunday, March 12 | 8:30AM - 11:30AM
The Current Wave - Cells as Therapeutics
Room: Oval Room

Speaker 2 of 6
Joanne Kurtzberg, Duke University, USA
Game Changers: Using Cord Blood to Help the Brain

Sunday, March 12 | 8:30AM - 11:30AM
The Current Wave - Cells as Therapeutics
Room: Oval Room

Speaker 3 of 6
Thomas Schulz, ViaCyte, Inc., USA
Development of Stem-Cell Derived, Islet Replacement for Type 1 Diabetes

Sunday, March 12 | 8:30AM - 11:30AM
The Current Wave - Cells as Therapeutics
Room: Oval Room


Coffee Break

Sunday, March 12 | 8:30AM - 11:30AM
The Current Wave - Cells as Therapeutics
Room: Oval Room

Speaker 5 of 6
Gordana V. Vunjak-Novakovic, Columbia University, USA
Human Cardiac and Tumor Platforms for Study of Disease

Sunday, March 12 | 8:30AM - 11:30AM
The Current Wave - Cells as Therapeutics
Room: Oval Room

Speaker 6 of 6
Jorge Mansilla-Soto, Memorial Sloan Kettering Cancer Center, USA
Short Talk: CRISPR/Cas9-Targeted Chimeric Antigen Receptor Enhances CAR T Cell-Mediated Tumor Eradication

Sunday, March 12 | 11:30AM - 5:00PM
On Own for Lunch


Sunday, March 12 | 2:30PM - 4:30PM
Workshop 3: 3-Dimensional Cellular Models
Room: Oval Room

Speaker 1 of 7
* Laura E. Niklason, Yale University, USA

Sunday, March 12 | 2:30PM - 4:30PM
Workshop 3: 3-Dimensional Cellular Models
Room: Oval Room

Speaker 2 of 7
Amir Ali Khan, University of Sharjah, United Arab Emirates
Unravelling the Gene Expression Profiles of the Early Differentiation of Mesenchymal Stem Cells into Neural Lineage

Sunday, March 12 | 2:30PM - 4:30PM
Workshop 3: 3-Dimensional Cellular Models
Room: Oval Room

Speaker 3 of 7
Sijie Sun, University of Washington, USA
Bioengineering 3D Human Skin Equivalent with Perfused Microvascular Network to Study Host-Viral Interactions During Infection

Sunday, March 12 | 2:30PM - 4:30PM
Workshop 3: 3-Dimensional Cellular Models
Room: Oval Room

Speaker 4 of 7
Christopher Hubert, Cleveland Clinic, Lerner Research Institute, USA
Modeling Glioblastoma through Cancer Stem Cell Organoids

Sunday, March 12 | 2:30PM - 4:30PM
Workshop 3: 3-Dimensional Cellular Models
Room: Oval Room

Speaker 5 of 7
Anastasia Korolj, University of Toronto, Canada
Biomimetic Curvature in Cell Culture Platform Improves Podocyte Differentiation in vitro

Sunday, March 12 | 2:30PM - 4:30PM
Workshop 3: 3-Dimensional Cellular Models
Room: Oval Room

Speaker 6 of 7
Sara Nunes Vasconcelos, University of Toronto, Canada
Diabetes Impairs Arterio-Venous Specification in Engineered Vascular Tissues in a Perivascular Cell Recruitment-Dependent Manner

Sunday, March 12 | 2:30PM - 4:30PM
Workshop 3: 3-Dimensional Cellular Models
Room: Oval Room

Speaker 7 of 7
Ryan LaRanger, University of Texas Southwestern Medical Center, USA
Engineering Reconstituted Decellularized Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells

Sunday, March 12 | 4:30PM - 5:00PM
Coffee Available
Room: Venetian Room


Sunday, March 12 | 5:00PM - 6:45PM
The Next Wave - Cells as Building Blocks
Room: Oval Room

Speaker 1 of 4
* Sara Nunes Vasconcelos, University of Toronto, Canada

Sunday, March 12 | 5:00PM - 6:45PM
The Next Wave - Cells as Building Blocks
Room: Oval Room

Speaker 2 of 4
Miguel Gonzalez-Andrades, Harvard University, USA
Tissue Engineered Corneas: A Clinical Reality?

Sunday, March 12 | 5:00PM - 6:45PM
The Next Wave - Cells as Building Blocks
Room: Oval Room

Speaker 3 of 4
Daniela Franco Bueno, Institute of Teaching and Research of Sirio Libanes Hospital, Brazil
Alveolar Bone Tissue Engineering for Cleft Lip and Palate

Sunday, March 12 | 5:00PM - 6:45PM
The Next Wave - Cells as Building Blocks
Room: Oval Room

Speaker 4 of 4
Laura E. Niklason, Yale University, USA
Engineered Arteries in Renal Failure and Arteriosclerosis

Sunday, March 12 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Oval Room


Sunday, March 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Venetian Room
No registration fees are used to fund alcohol served at this function.

Sunday, March 12 | 8:00PM - 11:00PM
Entertainment
Room: Venetian Room
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sunday, March 12 | 8:00PM - 11:00PM
Cash Bar
Room: Venetian Room


Monday, March 13 | 10:25AM - 10:25AM
Departure


*Session Chair.