Web Desc
Cell Death and Inflammation
joint with Integrating Metabolism and Immunity
Organizer(s): Seamus J. Martin and John Silke
Date: May 29 - June 02, 2017
Location: Royal Dublin Society, Dublin 4, Ireland
Organized in Collaboration with Science Foundation Ireland
Sponsored by Genentech, Inc. and Novo Nordisk A/S.
Summary of Meeting:
Cell death has long been known to be an important instigator of inflammation in sterile injury, as well as an amplifying factor in infection-associated inflammation, but the specific molecules underpinning this remain obscure. Understanding how dead and dying cells initiate and escalate inflammation has important implications for our understanding and treatment of autoinflammatory and infectious diseases. This meeting will explore current knowledge concerning the cellular constituents that drive inflammation (i.e., damage-associated molecular patterns), as well as how abnormal modes of cell death, such as necrosis, necroptosis and NETosis, can perturb inflammatory outputs and responses to dying cells. In particular, the conference aims to explore gaps in our current understanding of how dead and dying cells influence inflammatory responses in disease settings and will bring together experts in two major research fields, ”cell death” and ”inflammation,” for the purpose of clarifying what the key questions and therapeutic targets are in this rapidly evolving area. Many well-known physiological drivers of cell death (e.g., TNF, TRAIL, CD95/Fas), as well as the molecules that transduce signals from these receptors (e.g., RIPKs, IAPs, TRAFs, IKKs), are also centrally involved in promoting inflammation. However, the tremendous overlap between cell death and inflammatory signaling is only becoming appreciated of late, and although it is also widely accepted that the constituents of healthy cells can drive inflammation upon release into the extracellular space, the identity of these cellular constituents is still a matter of debate. This meeting will focus on teasing out the relationships between cell death and inflammatory signaling to highlight how perturbation of either of these processes invariably impacts upon the other. This meeting will also explore the nature of the molecules that promote and modulate inflammation during cell death. The meeting will bring together scientists from diverse fields (cell death, inflammation, cancer, innate immunity) that would not normally interact, and will identify and explore the key questions and directions that will shape the future of research in this field.
Scholarship Deadline: January 31 2017
Discounted Abstract Deadline: January 31 2017
Abstract Deadline: March 1 2017
Discounted Registration Deadline: March 29 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Genentech, Inc.Novo Nordisk A/SScience Foundation Ireland
We gratefully acknowledge additional support for this conference from:
Don Whitley Scientific Limited
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

EMBO Young Investigator Programme

Genentech, Inc.

GlaxoSmithKline
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI131600-01
Funding for this conference was made possible (in part) by 131600-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, May 29 | 4:00PM - 8:00PM
Arrival and Registration
Room: Hall 4


Monday, May 29 | 6:00PM - 8:00PM
Welcome Mixer
Room: Hall 4
No registration fees are used to fund alcohol served at this function.

Tuesday, May 30 | 8:00AM - 9:00AM
Breakfast
Room: Individual Hotel


Tuesday, May 30 | 9:00AM - 10:30AM
Welcome and Keynote Session (Joint)
Room: Hall 3

Speaker 1 of 5
* Hongbo Chi, St. Jude Children's Research Hospital, USA

Tuesday, May 30 | 9:00AM - 10:30AM
Welcome and Keynote Session (Joint)
Room: Hall 3

Speaker 2 of 5
* Seamus J. Martin, Trinity College Dublin, Ireland

Tuesday, May 30 | 9:00AM - 10:30AM
Welcome and Keynote Session (Joint)
Room: Hall 3

Speaker 3 of 5
Diane Mathis, Harvard Medical School, USA
T Cell Control of Organismal Metabolism

Tuesday, May 30 | 9:00AM - 10:30AM
Welcome and Keynote Session (Joint)
Room: Hall 3

Speaker 4 of 5
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Tissue Homeostasis and Inflammation

Tuesday, May 30 | 9:00AM - 10:30AM
Welcome and Keynote Session (Joint)
Room: Hall 3


Coffee Break

Tuesday, May 30 | 10:50AM - 12:45PM
Inflammatory Responses to Cell Death I
Room: Concert Hall

Speaker 1 of 6
* Seamus J. Martin, Trinity College Dublin, Ireland

Tuesday, May 30 | 10:50AM - 12:45PM
Inflammatory Responses to Cell Death I
Room: Concert Hall

Speaker 2 of 6
Kenneth L. Rock, University of Massachusetts Medical School, USA
DAMPs and Inflammation

Tuesday, May 30 | 10:50AM - 12:45PM
Inflammatory Responses to Cell Death I
Room: Concert Hall

Speaker 3 of 6
David Wallach, Weizmann Institute of Science, Israel
Non-Deadly Pro-Inflammatory Functions of Mechanisms that Signal for Programmed Necrosis

Tuesday, May 30 | 10:50AM - 12:45PM
Inflammatory Responses to Cell Death I
Room: Concert Hall

Speaker 4 of 6
John Silke, Walter and Eliza Hall Institute of Medical Research, Australia
Beware the MLKL, the Jaws that Bite: Uffish Thoughts on the Role of Necroptosis and Inflammation

Tuesday, May 30 | 10:50AM - 12:45PM
Inflammatory Responses to Cell Death I
Room: Concert Hall

Speaker 5 of 6
Stephen Tait, Cancer Research UK Beatson Institute, UK
Short Talk: Mitochondrial Permeabilization Engages NFkB and Anti-Tumor Immunity under Caspase-Deficient Conditions

Tuesday, May 30 | 10:50AM - 12:45PM
Inflammatory Responses to Cell Death I
Room: Concert Hall

Speaker 6 of 6
Kate E. Lawlor, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Cell Death-Induced Inflammasome Activation: Mechanisms and Disease Relevance

Tuesday, May 30 | 10:50AM - 1:00PM
Glucose Metabolism to Fuel Immune Cell Functions
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 1 of 5
* Jeffrey C. Rathmell, Vanderbilt University, USA
Glut1 and Metabolic Reprogramming of CD4 T Cell Subsets


Tuesday, May 30 | 10:50AM - 1:00PM
Glucose Metabolism to Fuel Immune Cell Functions
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 2 of 5
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
The Warburg Effect in LPS-Activated Macrophages


Tuesday, May 30 | 10:50AM - 1:00PM
Glucose Metabolism to Fuel Immune Cell Functions
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 3 of 5
Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Glucose Metabolism in Alternative Macrophage Activation


Tuesday, May 30 | 10:50AM - 1:00PM
Glucose Metabolism to Fuel Immune Cell Functions
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 4 of 5
Thomas Weichhart, Medical University of Vienna, Austria
Short Talk: Metabolic Aspects of Granuloma Formation by Macrophages Regulated by mTORC1


Tuesday, May 30 | 10:50AM - 1:00PM
Glucose Metabolism to Fuel Immune Cell Functions
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 5 of 5
Maxim Artyomov, Washington University in St. Louis, USA
Short Talk: Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation


Tuesday, May 30 | 12:45PM - 4:00PM
On Own for Lunch


Tuesday, May 30 | 12:45PM - 1:30PM
Poster Setup
Room: Hall 4


Tuesday, May 30 | 12:45PM - 10:00PM
Poster Viewing
Room: Hall 4


Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 1 of 8
* David K. Finlay, Trinity Biomedical Sciences Institute, Ireland


Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 2 of 8
* Madhusudhanan Sukumar, NCI, National Institutes of Health, USA


Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 3 of 8
Carlos Carmona-Fontaine, New York University, USA
Metabolic Origins of Spatial Organization in the Tumor Microenvironment


Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 4 of 8
Linda V. Sinclair, University of Dundee, UK
Temporally Regulated Amino Acid Uptake through SLC7A5 Is Required for T Follicular Helper Cell Differentiation


Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 5 of 8
Roger Geiger, Institute for Research in Biomedicine, Switzerland
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-Tumor Activity


Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 6 of 8
Dirk Brenner, Luxembourg Institute of Health, Luxembourg
Glutathione Primes T Cell Metabolism for Inflammation


Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 7 of 8
G-One Ahn, Pohang University of Science and Technology, South Korea
Reduced Glycolytic Metabolism in Adipose-Tissue Macrophages Facilitates Lipolysis in Mice


Tuesday, May 30 | 2:00PM - 3:30PM
Workshop 1: Molecular Controls of Cell Metabolism in the Imm
une System
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 8 of 8
Lena Pernas, University of Padua, Italy
Mitochondria Limit Toxoplasma Growth by Competing for Fatty Acids


Tuesday, May 30 | 3:30PM - 4:00PM
Coffee Available
Room: Concert Hall Foyer


Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
Room: Concert Hall

Speaker 1 of 7
* John Silke, Walter and Eliza Hall Institute of Medical Research, Australia

Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
Room: Concert Hall

Speaker 2 of 7
Peter Vandenabeele, VIB, Ghent University, Belgium
Role of Ferroptosis in Cancer Treatment and Immunogenic Cell Death (ICD)

Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
Room: Concert Hall

Speaker 3 of 7
Seamus J. Martin, Trinity College Dublin, Ireland
Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-1 Family Cytokines Released via Necrosis

Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
Room: Concert Hall

Speaker 4 of 7
Siddharth Balachandran, Fox Chase Cancer Center, USA
Short Talk: Influenza Virus-Activated DAI-RIPK3-Driven Cell Death

Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
Room: Concert Hall

Speaker 5 of 7
Andrew Oberst, University of Washington, USA
Short Talk: Death-Independent Roles of RIPK1 and RIPK3 in the Restriction of Neuroinvasive Flavivirus Infection

Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
Room: Concert Hall

Speaker 6 of 7
Murray CH Clarke, Cambridge University, UK
Short Talk: The Coagulation and Immune Systems Are Fundamentally Linked by the Activation of interleukin-1a by Thrombin

Tuesday, May 30 | 4:00PM - 6:00PM
Inflammatory Responses to Cell Death II
Room: Concert Hall

Speaker 7 of 7
Ranja Salvamoser, Australia
Short Talk: Impact of Deleting All Murine CARD Containing Caspases on Cell Death and Other Cell Signaling Pathways

Tuesday, May 30 | 4:00PM - 6:15PM
Transcriptional and Epigenetic Control in Immune Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 1 of 6
* Susan M. Kaech, The Salk Institute, USA


Tuesday, May 30 | 4:00PM - 6:15PM
Transcriptional and Epigenetic Control in Immune Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 2 of 6
Douglas R. Green, St. Jude Children's Research Hospital, USA
c-Myc and Metabolic Regulation of T Cell Activation and Differentiation


Tuesday, May 30 | 4:00PM - 6:15PM
Transcriptional and Epigenetic Control in Immune Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 3 of 6
John J. O'Shea, NIAMS, National Institutes of Health, USA
Regulatory Nodes in T Cells


Tuesday, May 30 | 4:00PM - 6:15PM
Transcriptional and Epigenetic Control in Immune Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 4 of 6
Hai-Hui (Howard) Xue, University of Iowa, USA
Short Talk: Runx3 Guards Cytotoxic CD8+ Effectors Against Tfh Deviation in Acute Viral Infection


Tuesday, May 30 | 4:00PM - 6:15PM
Transcriptional and Epigenetic Control in Immune Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 5 of 6
Mihai G. Netea, Radboud University, Netherlands
Metabolic and Epigenetic Reprogramming in Myeloid Cells


Tuesday, May 30 | 4:00PM - 6:15PM
Transcriptional and Epigenetic Control in Immune Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 6 of 6
Kenneth Smith, University of Cambridge, UK
Short Talk: Distinct Pathways Governing Susceptibility and Patient Outcome in Autoimmune and Inflammatory Disease


Tuesday, May 30 | 6:00PM - 7:00PM
Social Hour with Lite Bites
Room: Hall 4
No registration fees are used to fund alcohol served at this function.

Tuesday, May 30 | 6:30PM - 9:00PM
Poster Session 1
Room: Hall 4


Wednesday, May 31 | 8:00AM - 9:00AM
Breakfast
Room: Individual Hotel


Wednesday, May 31 | 8:30AM - 9:00AM
Poster Setup
Room: Hall 4


Wednesday, May 31 | 9:00AM - 5:00PM
Poster Viewing
Room: Hall 4


Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
Room: Concert Hall

Speaker 1 of 10
* Kim Newton, Genentech, Inc., USA

Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
Room: Concert Hall

Speaker 2 of 10
Mads Gyrd-Hansen, University of Oxford, UK
EMBO Young Investigator Lecture: Regulation of Ubiquitination in Inflammatory Signaling

Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
Room: Concert Hall

Speaker 3 of 10
Henning Walczak, University College London, Cancer Institute, UK
Cell Death and Ubiquitin in Cancer, Inflammation and Immunity

Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
Room: Concert Hall

Speaker 4 of 10
Rune Busk Damgaard, Medical Research Council Laboratory of Molecular Biology, UK
Short Talk: The Deubiquitinase OTULIN Restricts M1-Linked Ubiquitin Signaling to Prevent Inflammation and Autoimmunity

Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
Room: Concert Hall

Speaker 5 of 10
Patricia Brazee, Northwestern University, USA
Short Talk: LUBAC Mediated Epithelial Signaling During Influenza Infection

Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
Room: Concert Hall


Coffee Break

Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
Room: Concert Hall

Speaker 7 of 10
Marion MacFarlane, MRC Toxicology Unit, UK
FADD: Caspase-8 Signalling Complexes and Co-ordinated Control of Life/Death Decisions

Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
Room: Concert Hall

Speaker 8 of 10
Pascal Meier, Institute of Cancer Research, UK
Ubiquitin Signaling in Cell Death and Inflammation

Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
Room: Concert Hall

Speaker 9 of 10
Nader Yatim, Institut Pasteur, France
Short Talk: RIPK3 in Dendritic Cells Promotes Cross-Priming Upon Stimulation with dsRNA

Wednesday, May 31 | 9:00AM - 12:00PM
Inflammatory Signaling I
Room: Concert Hall

Speaker 10 of 10
Todd Douglas, McGill University, Canada
Short Talk: Caspase-Mediated Cleavage of HOIP Terminates LUBAC Function and Promotes Cell Death 

Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 1 of 8
* Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany


Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 2 of 8
Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Mitochondrial Priming By CD28


Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 3 of 8
Dan R. Littman, HHMI/New York University School of Medicine, USA
Regulation of RORgt Function in Lymphocytes


Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 4 of 8
Laurence A. Turka, Rheos Medicines, USA
Short Talk: Maintenance of CD4+ T Cell Metabolic Fitness through Regulation of Foxo1


Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
This session is from Metabolism and Immunity
Room: Hall 3


Coffee Break


Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 6 of 8
Tim D. Sparwasser, Institute of Infection and Immunology, Germany
Fatty Acid Metabolism in the Development and Function of T Cell Subsets


Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 7 of 8
Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Metabolic Pathways that Regulate Development of Pathogenic Th17 Cells and Autoimmunity


Wednesday, May 31 | 9:00AM - 12:15PM
Fatty Acids and Metabolic Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 8 of 8
Daniel W. McVicar, National Institutes of Health, USA
Short Talk: Itaconic Acid Mediates Crosstalk between Macrophage Metabolism and Tumor Progression


Wednesday, May 31 | 12:00PM - 1:00PM
Lunch
Room: Hall 4


Wednesday, May 31 | 1:00PM - 3:30PM
Poster Session 2
Room: Hall 4


Wednesday, May 31 | 3:30PM - 4:00PM
Coffee Available
Room: Concert Hall Foyer


Wednesday, May 31 | 4:00PM - 6:00PM
Inflammatory Signaling II
Room: Concert Hall

Speaker 1 of 6
* Eric H. Baehrecke, University of Massachusetts Medical School, USA

Wednesday, May 31 | 4:00PM - 6:00PM
Inflammatory Signaling II
Room: Concert Hall

Speaker 2 of 6
Ana Martin-Villalba, DKFZ German Cancer Research Center, Germany
CD95 Inflammatory Activities: A Tale of Myeloid Cells and Vessels

Wednesday, May 31 | 4:00PM - 6:00PM
Inflammatory Signaling II
Room: Concert Hall

Speaker 3 of 6
Domagoj Vucic, Genentech, Inc., USA
Regulation of Inflammatory Cell Death Signaling by RIP Kinases

Wednesday, May 31 | 4:00PM - 6:00PM
Inflammatory Signaling II
Room: Concert Hall

Speaker 4 of 6
Elizabeth K. Brint, University College Cork, Ireland
Short Talk: Engagement of Fas Differentially Regulates the Production of LPS-Induced Pro-Inflammatory Cytokines and Type I Interferons

Wednesday, May 31 | 4:00PM - 6:00PM
Inflammatory Signaling II
Room: Concert Hall

Speaker 5 of 6
Igor E. Brodsky, University of Pennsylvania, USA
Short Talk: RIPK1 Kinase-Dependent Apoptosis Promotes Antibacterial Immunity in Response to Pathogen Inhibition of Inflammatory Signaling

Wednesday, May 31 | 4:00PM - 6:00PM
Inflammatory Signaling II
Room: Concert Hall

Speaker 6 of 6
Cristina Giogha, Hudson Institute of Medical Research, Australia
Short Talk: A Bacterial Cysteine Protease Effector Targets RHIM Proteins to Block Host Immune Signaling

Wednesday, May 31 | 4:00PM - 6:15PM
Mitochondria as Platforms for Key Intracellular Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 1 of 6
* Douglas R. Green, St. Jude Children's Research Hospital, USA


Wednesday, May 31 | 4:00PM - 6:15PM
Mitochondria as Platforms for Key Intracellular Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 2 of 6
Navdeep S. Chandel, Northwestern University, USA
Mitochondria as Signaling Organelles


Wednesday, May 31 | 4:00PM - 6:15PM
Mitochondria as Platforms for Key Intracellular Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 3 of 6
Gerald S. Shadel, The Salk Institute for Biological Studies, USA
A Mitochondrial DNA Stress-Induced ISG Response


Wednesday, May 31 | 4:00PM - 6:15PM
Mitochondria as Platforms for Key Intracellular Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 4 of 6
David Artis, Weill Cornell Medical College, USA
Immune Regulation at Barrier Surfaces


Wednesday, May 31 | 4:00PM - 6:15PM
Mitochondria as Platforms for Key Intracellular Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 5 of 6
Mercedes Rincon, University of Vermont, USA
Short Talk: MCJ (DnaJC15) Negatively Regulates CD8+ T Cell Mitochondrial Respiration and Immune Effector Functions


Wednesday, May 31 | 4:00PM - 6:15PM
Mitochondria as Platforms for Key Intracellular Signaling
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 6 of 6
Ping-Chih Ho, University of Lausanne, Switzerland
Short Talk: Integration of alpha-Ketoglutarate/Succinate Balance Controls Macrophage Polarization through Immunometabolic and Epigenetic Reprogramming


Wednesday, May 31 | 6:00PM - 6:00PM
On Own for Dinner
No registration fees are used to fund alcohol served at this function.

Thursday, June 01 | 8:00AM - 9:00AM
Breakfast
Room: Individual Hotel


Thursday, June 01 | 8:30AM - 9:00AM
Poster Setup
Room: Hall 4


Thursday, June 01 | 9:00AM - 5:00PM
Poster Viewing
Room: Hall 4


Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
Room: Concert Hall

Speaker 1 of 9
* Thomas Brunner, University of Konstanz, Germany

Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
Room: Concert Hall

Speaker 2 of 9
Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Phagocyte Responses to Dying Cells

Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
Room: Concert Hall

Speaker 3 of 9
Eric H. Baehrecke, University of Massachusetts Medical School, USA
Inflammatory Signaling, Autophagy and Dying Cell Clearance

Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
Room: Concert Hall

Speaker 4 of 9
Thomas H. Oguin, National Institute of Environmental Health Sciences, USA
Short Talk: LC3-Associated Phagocytosis Is Required to Defend Against Environmental Bacterial Infection

Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
Room: Concert Hall


Coffee Break

Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
Room: Concert Hall

Speaker 6 of 9
Ed C. Lavelle, Trinity College Dublin, Ireland
Role of IL-1 Family Cytokines in Adjuvanticity

Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
Room: Concert Hall

Speaker 7 of 9
Shigekazu Nagata, IFReC, Osaka University, Japan
Exposure of Phosphatidylserine to the Cell Surface

Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
Room: Concert Hall

Speaker 8 of 9
Akira Shibuya, University of Tsukuba, Japan
Short Talk: Apoptotic Epithelial Cells Control Regulatory T Cell Expansion  

Thursday, June 01 | 9:00AM - 12:00PM
Tissue Responses to Dying Cells
Room: Concert Hall

Speaker 9 of 9
Conor J. Kearney, Peter MacCallum Cancer Centre, Australia
Short Talk: IAP Antagonists Promote Cytotoxic Lymphocyte Anti-Tumor Immunity

Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 1 of 9
* Laurence A. Turka, Rheos Medicines, USA


Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 2 of 9
* Mercedes Rincon, University of Vermont, USA


Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 3 of 9
Giuseppe Matarese, Università degli Studi di Napoli Federico II, Italy
Metabolic Control of Immune Tolerance and Autoimmune Diseases


Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 4 of 9
Jonathan D. Powell, Johns Hopkins University School of Medicine, USA
mTOR Signaling in T Cell Fate, Activation and Metabolism


Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 5 of 9
Bin Li, Shanghai Institute of Immunology, China
Short Talk: Regulation of Treg Cell Metabolism and Function by Pkm2 and Foxp3


Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
This session is from Metabolism and Immunity
Room: Hall 3


Coffee Break


Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 7 of 9
Hongbo Chi, St. Jude Children's Research Hospital, USA
mTORC1 Signaling and Systems Proteomics in T Cell Metabolic Reprogramming


Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 8 of 9
Russell G. Jones, Van Andel Research Institute, USA
Rethinking Metabolic Reprogramming in T Cells


Thursday, June 01 | 9:00AM - 12:15PM
Interplay between mTOR/AMPK Signaling and Cell Metabolism
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 9 of 9
Jeroen Roose, University of California, San Francisco, USA
Short Talk: Tonic Signals to Regulate Transcriptional, Translational, and Metabolic Programs in CD4 T Cells


Thursday, June 01 | 12:00PM - 1:00PM
Lunch
Room: Hall 4


Thursday, June 01 | 1:00PM - 3:30PM
Poster Session 3
Room: Hall 4


Thursday, June 01 | 3:30PM - 4:00PM
Coffee Available
Room: Concert Hall Foyer


Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
Room: Concert Hall

Speaker 1 of 7
* Cristina Muñoz-Pinedo, Institut d'Investigacio Biomedica de Bellvitge, Spain

Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
Room: Concert Hall

Speaker 2 of 7
Junying Yuan, Harvard Medical School, USA
The Role and Mechanism of RIPK1 in Cell Death and Neurodegeneration

Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
Room: Concert Hall

Speaker 3 of 7
Kevin M. Ryan, Beatson Institute for Cancer Research, UK
The p53 Pathway and Inflammation

Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
Room: Concert Hall

Speaker 4 of 7
Erwin F. Wagner, Spanish National Cancer Research Centre, Spain
Stress Signaling in Inflammation and Cancer

Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
Room: Concert Hall

Speaker 5 of 7
Lisa Bouchier-Hayes, Baylor College of Medicine, USA
Short Talk: Caspase-1 and Caspase-5 Are Differentially Activated by Extracellular Heme

Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
Room: Concert Hall

Speaker 6 of 7
Joanna Majkut, Queen's University Belfast, UK
Short Talk: Development and Pre-Clinical Assessment of a First-in-Class Small Molecule Inhibitor of FLIP

Thursday, June 01 | 4:00PM - 6:00PM
Stress Signals and Inflammation
Room: Concert Hall

Speaker 7 of 7
Adam Lacy-Hulbert, Benaroya Research Institute, USA
Short Talk: A Forward Genetic Screen to Identify Mechanisms of Resistance to Caspase-Mediated Cell Death Induced by Pore-Forming Toxins

Thursday, June 01 | 4:00PM - 6:15PM
Immune-Tissue Interaction in Inflammation and Metabolic Dise
ase
This session is from Metabolism and Immunity

Room: Hall 3

Speaker 1 of 6
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA


Thursday, June 01 | 4:00PM - 6:15PM
Immune-Tissue Interaction in Inflammation and Metabolic Dise
ase
This session is from Metabolism and Immunity

Room: Hall 3

Speaker 2 of 6
Axel Kallies, University of Melbourne, Australia
Molecular Regulation of Adipose Tissue-Resident Regulatory T Cell Development


Thursday, June 01 | 4:00PM - 6:15PM
Immune-Tissue Interaction in Inflammation and Metabolic Dise
ase
This session is from Metabolism and Immunity

Room: Hall 3

Speaker 3 of 6
Lydia Lynch, Harvard Medical School, USA
The Interdependence of Systemic and Cellular Metabolism in Innate Immunity


Thursday, June 01 | 4:00PM - 6:15PM
Immune-Tissue Interaction in Inflammation and Metabolic Dise
ase
This session is from Metabolism and Immunity

Room: Hall 3

Speaker 4 of 6
David K. Finlay, Trinity Biomedical Sciences Institute, Ireland
Short Talk: Fueling Natural Killer Cell Anti-Tumor Responses


Thursday, June 01 | 4:00PM - 6:15PM
Immune-Tissue Interaction in Inflammation and Metabolic Dise
ase
This session is from Metabolism and Immunity

Room: Hall 3

Speaker 5 of 6
Richard M. Locksley, HHMI/University of California, San Francisco, USA
Innate Helper Type 2 Cells (ILC2s) and Intestinal Homeostasis


Thursday, June 01 | 4:00PM - 6:15PM
Immune-Tissue Interaction in Inflammation and Metabolic Dise
ase
This session is from Metabolism and Immunity

Room: Hall 3

Speaker 6 of 6
Giuseppe Danilo Norata, University of Milan, Italy
Short Talk: Dendritic Cells’ Derived Apolipoprotein E Orchestrates Adaptive Immune Response by Controlling Cellular Lipid Metabolism


Thursday, June 01 | 6:00PM - 6:00PM
On Own for Dinner
No registration fees are used to fund alcohol served at this function.

Friday, June 02 | 8:00AM - 9:00AM
Breakfast
Room: Individual Hotel


Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
Room: Concert Hall

Speaker 1 of 10
* Domagoj Vucic, Genentech, Inc., USA

Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
Room: Concert Hall

Speaker 2 of 10
Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany
NETosis and Inflammation

Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
Room: Concert Hall

Speaker 3 of 10
Thomas Brunner, University of Konstanz, Germany
Extra-Adrenal Synthesis of Immunoregulatory Glucocorticoids and its Implication in Local Tissue Homeostasis, Inflammation and Cancer

Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
Room: Concert Hall

Speaker 4 of 10
Ling-Ling An, MedImmune, Inc., USA
Short Talk: ICs-Induced NETosis Requires PAD4 but Not Histone Citrullination

Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
Room: Concert Hall

Speaker 5 of 10
Cristina Muñoz-Pinedo, Institut d'Investigacio Biomedica de Bellvitge, Spain
Short Talk: Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors

Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
Room: Concert Hall


Coffee Break

Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
Room: Concert Hall

Speaker 7 of 10
Kim Newton, Genentech, Inc., USA
Regulation of Cell Death by RIPK1 and Caspase-8

Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
Room: Concert Hall

Speaker 8 of 10
Kate Schroder, University of Queensland, Australia
Myeloid Cell Identity Shapes Inflammasome Signaling Pathways and Cell Death Decisions

Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
Room: Concert Hall

Speaker 9 of 10
Jerome Estaquier, CHU de Québec Research Center Infectious Disease Research Center, Canada
Short Talk: Anti-apoptosis Agent Prevents AIDS

Friday, June 02 | 9:00AM - 12:00PM
Alternative Cell Death Modalities and Inflammation
Room: Concert Hall

Speaker 10 of 10
James M. Murphy, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Mechanistic Studies of How the Pseudokinase, MLKL, Is Activated and Kills Cells by Necroptosis

Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 1 of 8
* Joel D. Schilling, Washington University School of Medicine, USA


Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 2 of 8
Mark A. Febbraio, Monash Institute of Pharmaceutical Sciences, Australia
How Do Macrophages Sense Nutrient Overload to Induce an Inflammatory Response?


Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 3 of 8
Susan M. Kaech, The Salk Institute, USA
Anti-Tumor T Cells – You Are What You Eat


Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 4 of 8
Laurence Morel, University of Florida, USA
Short Talk: Unique Requirement of High Levels of Glucose Metabolism by Autoreactive Follicular Helper T Cells


Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
This session is from Metabolism and Immunity
Room: Hall 3


Coffee Break


Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 6 of 8
Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Gut Microbe, Growth Factor Signaling and Metabolic Regulation of Wasting Disease


Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 7 of 8
Mala Maini, University College London, UK
Metabolic Regulation of T Cell Immunity in Viral Hepatitis


Friday, June 02 | 9:00AM - 12:15PM
Nutrient Sensing and Signaling in Immune Microenvironment
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 8 of 8
Andreas Bergthaler, Austrian Academy of Sciences, Austria
Short Talk: Systemic Crosstalk of Metabolism and Inflammation in Viral Infection


Friday, June 02 | 12:00PM - 5:00PM
On Own for Lunch


Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 1 of 10
* Martin Thurnher, Medical University of Innsbruck, Austria


Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 2 of 10
* Julian J. Lum, British Columbia Cancer Agency, Canada


Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 3 of 10
Jennifer Martinez, NIEHS, National Institutes of Health, USA
LC3-Associated Phagocytosis Links Efferocytosis to Inflammation and Metabolism


Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 4 of 10
Rianne G. J. W. van der Windt, Academic Medical Center, Netherlands
Impact of Signals from the Tumor Microenvironment on Chronic Lymphocytic Leukemia Metabolism


Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 5 of 10
Sagar P. Bapat, University of California, San Francisco, USA
PPARg Activation Suppresses Th2-Driven Atopic Disease via Metabolic Reprogramming


Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 6 of 10
Rafael de Queiroz Prado, NIAID, National Institutes of Health, USA
The L-Arginine Transporter Slc7a2 Regulates Asthma Pathogenesis by Inhibiting Inflammasome Activation in Non-Hematopoietic Cells


Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 7 of 10
Andrea J. Wolf, Cedars-Sinai Medical Center, USA
A Role for the Glycolytic Enzyme, Hexokinase, in Innate Immune Sensing by the NLRP3 Inflammasome


Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 8 of 10
Autumn G. York, Yale University, USA
Synthesis of Mono-Unsaturated Fatty Acids Negatively Regulates Inflammation


Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 9 of 10
Bin Zheng, Harvard Medical School, USA
Targeting Metabolic Vulnerabilities of MDSCs to Enhance the Anti-Tumor Activity of PD-1 Blockade


Friday, June 02 | 2:30PM - 4:30PM
Workshop 2: Importance of Metabolic Reprogramming in in vivo
Functioning of the Immune System and Immune-Mediated Diseases
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 10 of 10
Bart Everts, Leiden University Medical Center, Netherlands
LKB1 Expressed in Dendritic Cells Governs the Development of Thymus-Derived Regulatory T Cells


Friday, June 02 | 4:30PM - 5:00PM
Coffee Available
Room: Concert Hall Foyer


Friday, June 02 | 5:00PM - 6:00PM
Inflammation and Cancer
Room: Concert Hall

Speaker 1 of 3
* Peter Vandenabeele, VIB, Ghent University, Belgium

Friday, June 02 | 5:00PM - 6:00PM
Inflammation and Cancer
Room: Concert Hall

Speaker 2 of 3
Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
Inflammation in the Tumor Microenvironment

Friday, June 02 | 5:00PM - 6:00PM
Inflammation and Cancer
Room: Concert Hall

Speaker 3 of 3
Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Inflammatory Regulators and Cancer Progression

Friday, June 02 | 5:00PM - 6:45PM
Microbiota Metabolism and Immune Cell Functions
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 1 of 4
* Laurence Morel, University of Florida, USA


Friday, June 02 | 5:00PM - 6:45PM
Microbiota Metabolism and Immune Cell Functions
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 2 of 4
Yasmine Belkaid, NIAID, National Institutes of Health, USA
White Adipose Tissue is a Hub for Memory T Cells and Promotes Memory Responses


Friday, June 02 | 5:00PM - 6:45PM
Microbiota Metabolism and Immune Cell Functions
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 3 of 4
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Immunometabolism


Friday, June 02 | 5:00PM - 6:45PM
Microbiota Metabolism and Immune Cell Functions
This session is from Metabolism and Immunity
Room: Hall 3

Speaker 4 of 4
Daniel Mucida, Rockefeller University, USA
Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection


Friday, June 02 | 6:00PM - 6:45PM
Closing Keynote Address
Room: Concert Hall

Speaker 1 of 2
* Seamus J. Martin, Trinity College Dublin, Ireland

Friday, June 02 | 6:00PM - 6:45PM
Closing Keynote Address
Room: Concert Hall

Speaker 2 of 2
Douglas R. Green, St. Jude Children's Research Hospital, USA
Cell Death as a Key Modulator of Inflammation: What Are the Key Factors?

Friday, June 02 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Concert Hall


Friday, June 02 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Metabolism and Immunity
Room: Hall 3


Friday, June 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Hall 4
No registration fees are used to fund alcohol served at this function.

Friday, June 02 | 8:00PM - 11:00PM
Special appearance for one night only - The Metabollix led b
y Luke O'Neill with special guests
Room: Hall 4
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources. Novo Nordisk A/S funding is not being used for this function.

Friday, June 02 | 8:00PM - 11:00PM
Cash Bar
Room: Hall 4


Saturday, June 03 | 10:25AM - 10:25AM
Departure


*Session Chair.